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1.
Medicine (Baltimore) ; 100(40): e27371, 2021 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-34622838

RESUMO

BACKGROUND: Anemia in patients with chronic kidney disease (CKD) presents significant impacts on patients, the health-care system, and financial resources. Therefore, this study aimed to identify the risk factors of anemia among CKD patients. METHODS: This meta-analysis was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols statement guidelines. Studies were identified through systematic searches in September 2021 with no restrictions on date and time, and publication status using the following bibliographic databases: Embase, Medline, PubMed, Web of Science, Science Direct, and the Cochrane Library. The search was conducted using the following terms and phrases: "anemia", "risk factors", "associated factors", "chronic kidney injury", "chronic kidney disease", and "chronic renal insufficiency". The quality of each included study was assessed according to the Newcastle-Ottawa scale. Meta-analysis was performed using STATATM version 14 statistical software for WindowsTM. RESULTS: The results of this systematic review and meta-analysis will be published in a peer-reviewed journal. CONCLUSION: This meta-analysis may help policymakers and program managers design evidence-based interventions on preventing the occurrence of anemia with CKD patient populations.


Assuntos
Anemia/etiologia , Insuficiência Renal Crônica/complicações , Humanos , Metanálise como Assunto , Fatores de Risco , Revisões Sistemáticas como Assunto
2.
BMC Cancer ; 21(1): 1073, 2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34598694

RESUMO

BACKGROUND: This study aimed to evaluate the feasibility, safety, and efficacy of postoperative adjuvant chemotherapy with docetaxel/cisplatin/S-1 (DCS) following S-1 therapy in patients with stage III gastric cancer after curative gastrectomy. METHODS: Patients with stage III gastric cancer who underwent D2 gastrectomy were enrolled. Adjuvant chemotherapy was initiated within 8 weeks of gastrectomy. The first cycle of chemotherapy consisted of S-1 monotherapy (day 1-14), followed by a 7-day rest period. Cycles 2 and 3 consisted of the following: S-1 (day 1-14) administration, followed by a 14-day rest period, and an intravenous infusion of cisplatin and docetaxel on days 1 and 15. After two cycles, S-1 was administered for up to 1 year. RESULTS: Thirty patients were enrolled between 2014 and 2017. Febrile neutropenia of grade 3 or higher was the most common hematological toxicity with 4 patients (13.3%). Other hematological toxicities of grade 3 or higher were as follows: neutropenia in 3 (10.0%), leukopenia in 3 (10.0%), and anemia in 2 (6.7%) patients. Most frequent non-hematological toxicity of grade 3 was anorexia (n = 4, 13.3%) and general fatigue (n = 3, 10.0%); no grade 4 non-hematological toxicities were observed. Twenty-five patients (83.3%) completed two cycles of DCS treatment and 18 (60.0%) completed subsequent S-1 treatment for 1 year. The relative dose intensity of docetaxel and cisplatin was 0.86 and that of S-1 was 0.88. CONCLUSION: The DCS regimen can be acceptable as an adjuvant chemotherapy and offers an effective postoperative treatment option for stage III gastric cancer patients. TRIAL REGISTRATION NUMBER: UMIN000012785 . DATE OF REGISTRY: 08/01/2014.


Assuntos
Adenocarcinoma/tratamento farmacológico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Gástricas/tratamento farmacológico , Adenocarcinoma/patologia , Adenocarcinoma/cirurgia , Idoso , Anemia/induzido quimicamente , Anorexia/induzido quimicamente , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Quimioterapia Adjuvante/efeitos adversos , Quimioterapia Adjuvante/métodos , Neutropenia Febril Induzida por Quimioterapia/etiologia , Cisplatino/administração & dosagem , Cisplatino/efeitos adversos , Docetaxel/administração & dosagem , Docetaxel/efeitos adversos , Esquema de Medicação , Combinação de Medicamentos , Fadiga/induzido quimicamente , Estudos de Viabilidade , Feminino , Humanos , Leucopenia/induzido quimicamente , Masculino , Pessoa de Meia-Idade , Neutropenia/induzido quimicamente , Ácido Oxônico/administração & dosagem , Ácido Oxônico/efeitos adversos , Cooperação do Paciente , Neoplasias Gástricas/mortalidade , Neoplasias Gástricas/patologia , Neoplasias Gástricas/cirurgia , Tegafur/administração & dosagem , Tegafur/efeitos adversos
3.
Gan To Kagaku Ryoho ; 48(10): 1255-1257, 2021 Oct.
Artigo em Japonês | MEDLINE | ID: mdl-34657058

RESUMO

The patient was a 61-year-old woman who presented to the hospital with the chief complaints of anemia and thrombocytopenia. There was a mass in her left breast, and a needle biopsy with pathology revealed invasive ductal carcinoma, which was HR-positive and HER2-negative. A PET scan revealed multiple bone metastases, which were confirmed on bone marrow biopsy, leading to the diagnosis of bone marrow carcinomatosis. As the patient was in good general condition, an aromatase inhibitor(AI)therapy was selected. Rapid improvements in her hemoglobin level and platelet count were observed. At 19 months after the start of treatment, we were able to perform a left mastectomy with left axillary lymph node dissection. The histological evaluation of her response to treatment was Grade 2a, and severe lymph node metastasis was observed. The patient continued to receive the AI postoperatively. Thirty-two months after the start of treatment, there was no evidence of cancer on clinical imaging. Although it is rare for bone marrow carcinomatosis to occur, as in the present case, it is also notable that the patient had been in long-term remission with consistent AI therapy.


Assuntos
Anemia , Neoplasias da Mama , Neoplasias Peritoneais , Trombocitopenia , Anemia/tratamento farmacológico , Anemia/etiologia , Inibidores da Aromatase , Medula Óssea , Neoplasias da Mama/complicações , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/cirurgia , Feminino , Humanos , Mastectomia , Pessoa de Meia-Idade , Trombocitopenia/tratamento farmacológico , Trombocitopenia/etiologia
6.
BMJ Case Rep ; 14(10)2021 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-34607817

RESUMO

Pericardial effusion secondary to isolated severe iron-deficiency anaemia is an extremely rare condition. We present a case with severe anaemia presented with moderate pericardial effusion. Pericardial effusion completely resolved with correction of anaemia.


Assuntos
Anemia Ferropriva , Anemia , Derrame Pericárdico , Anemia Ferropriva/complicações , Humanos , Derrame Pericárdico/complicações , Derrame Pericárdico/diagnóstico por imagem
7.
MMW Fortschr Med ; 163(17): 60-62, 2021 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-34595649
8.
BMJ Case Rep ; 14(10)2021 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-34645629

RESUMO

A 22-year-old pregnant woman was referred to our fetal medicine unit due to severe fetal growth restriction at 26 weeks of gestation. An extensive detailed ultrasound revealed signs of bilateral periventricular hyperechogenicity, suggesting fetal infection potentially due to cytomegalovirus (CMV). Doppler ultrasound showed a high peak systolic velocity in the middle cerebral artery. Percutaneous umbilical cord blood sampling confirmed fetal CMV infection and severe fetal anaemia. We present this case to highlight the importance of fetal anaemia, which can be fatal regardless of whether it is associated with generalised oedema or hydrops fetalis.


Assuntos
Anemia , Infecções por Citomegalovirus , Adulto , Anemia/etiologia , Infecções por Citomegalovirus/complicações , Feminino , Retardo do Crescimento Fetal/diagnóstico por imagem , Retardo do Crescimento Fetal/etiologia , Feto , Humanos , Hidropisia Fetal/diagnóstico por imagem , Hidropisia Fetal/etiologia , Gravidez , Ultrassonografia Pré-Natal , Adulto Jovem
9.
Trials ; 22(1): 712, 2021 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-34663434

RESUMO

BACKGROUND: Erythropoiesis and iron homeostasis are closely related; anemia due to lower-risk myelodysplastic syndromes (MDS) remains difficult to treat. In the last decade, we have been committed to improving the regulation of iron metabolism using traditional Chinese medicine (TCM). Previous studies have found that the TCM Yi Gong San (YGS) can reduce the expression of transferrin by inhibiting hepcidin overexpression caused by inflammation, promote the outward transfer of intracellular iron, and improve the symptoms of anemia. Here, our study aimed to compare the efficacy of a conventional drug with YGS with that of conventional medicine with placebo to provide a scientific basis for making clinical decisions. METHODS: A prospective, multicenter, double-blinded, randomized controlled clinical trial will be conducted to evaluate the therapeutic efficacy of conventional medicine combined with YGS with that of conventional medicine alone in the treatment of MDS. A total of 60 patients would be enrolled in this study, with each treatment group (conventional medicine + YGS and conventional medicine + placebo) comprising 30 patients. Oral medication would be administered twice daily for 3 months. All patients would be followed up throughout the 3-month period. The primary outcome was measured by assessing blood hemoglobin level. The secondary outcome was measured by assessing TCM symptom score, iron metabolism, hepcidin levels, and inflammatory factors. DISCUSSION: This trial would aim to demonstrate the effectiveness and feasibility of YGS in the treatment of lower-risk MDS anemia, as well as its impact on inflammatory factors and iron metabolism in patients with lower-risk MDS. TRIAL REGISTRATION: Chinese Clinical Trials Registry ( http://www.chictr.org.cn/ ) ChiCTR1900026774 .  Registered on October 21, 2019.


Assuntos
Anemia , Medicamentos de Ervas Chinesas , Síndromes Mielodisplásicas , Anemia/diagnóstico , Anemia/tratamento farmacológico , Anemia/etiologia , China , Método Duplo-Cego , Medicamentos de Ervas Chinesas/efeitos adversos , Humanos , Estudos Multicêntricos como Assunto , Síndromes Mielodisplásicas/diagnóstico , Síndromes Mielodisplásicas/tratamento farmacológico , Estudos Prospectivos , Ensaios Clínicos Controlados Aleatórios como Assunto
10.
Rev Bras Enferm ; 75(1): e20210064, 2021.
Artigo em Inglês, Português | MEDLINE | ID: mdl-34614085

RESUMO

OBJECTIVE: To evaluate the presence of anemia in patients with chronic lower limb ulcers based on profile and hematometric indices. METHOD: This is a cross-sectional study carried out in a university hospital in Rio de Janeiro. The sample was composed of 64 participants with lower limb ulcers and evolution time greater than 12 weeks. Data was collected between May/2016 and December/2017 from hematological analyses, records from medical records, and wound assessment form. RESULTS: 36 (56.2%) were male; 38 (59.4%) between 60 and 80 years old; 56 (87.5%) with chronic diseases and 52 (81.2%) with venous ulcers. 6 years mean of active ulceration. Anemia was detected in 36 (56.2%), 27 (75%) of which were normochromic and normocytic; 14 (38.8%) had deficiency anemia recorded in their medical chart. CONCLUSION: The low hemoglobin concentration is recurrent among the participants characterizing an anemia condition, whose profile reveals congruence to the anemia of chronic disease.


Assuntos
Anemia , Úlcera da Perna , Idoso , Idoso de 80 Anos ou mais , Anemia/complicações , Anemia/epidemiologia , Brasil/epidemiologia , Estudos Transversais , Humanos , Laboratórios , Úlcera da Perna/complicações , Úlcera da Perna/epidemiologia , Masculino , Pessoa de Meia-Idade
11.
J Med Case Rep ; 15(1): 463, 2021 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-34538261

RESUMO

BACKGROUND: In ineffective erythropoiesis, hepcidin synthesis is suppressed by erythroid regulators, namely erythroferrone and growth differentiation factor-15. For the first time, the hypothesis that iron overload in megaloblastic anemia may be related to ineffective erythropoiesis is explored by describing the kinetics of hepcidin, erythroferrone, and growth differentiation factor-15 levels in a patient diagnosed with megaloblastic anemia associated with iron overload. CASE PRESENTATION: An 81-year-old Caucasian male was admitted for fatigue. He had type-2 diabetes previously treated with metformin, ischemic cardiac insufficiency, and stage-3 chronic kidney disease. Vitiligo was observed on both hands. Biological tests revealed normocytic non-regenerative anemia associated with hemolysis, thrombocytopenia, and elevated sideremia, ferritin, and transferrin saturation levels. Megaloblastic anemia was confirmed with undetectable blood vitamin B12 and typical cytological findings like hyper-segmented neutrophils in blood and megaloblasts in bone marrow. The patient received vitamin B12 supplementation. At 3 months, biological parameters reached normal values. Hepcidin kinetics from diagnosis to 3 months inversely correlated with those of erythroferrone and growth differentiation factor-15. CONCLUSIONS: This case suggests that iron-overload mechanisms of dyserythropoietic anemias may apply to megaloblastic anemias.


Assuntos
Anemia Megaloblástica , Anemia , Sobrecarga de Ferro , Idoso de 80 Anos ou mais , Anemia Megaloblástica/diagnóstico , Anemia Megaloblástica/tratamento farmacológico , Eritropoese , Humanos , Ferro , Sobrecarga de Ferro/tratamento farmacológico , Masculino
12.
J Glob Health ; 11: 13006, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34484713

RESUMO

Background: Adolescence is a highly vulnerable period of human life characterized by substantial physiological and cognitive changes for which adequate nutrition is crucial. To date, evidence on determinants, prevalence, and trends of undernutrition and anemia for the entire West and Central African region is missing. This paper provides evidence on trends and levels of adolescent anemia and undernutrition in West and Central Africa. Methods: We pooled all Demographic and Health Surveys (DHS) for West and Central African countries that were conducted between 1986 and 2017 to analyze levels and trends of adolescent anemia and undernutrition. We investigated the association of adolescent undernutrition and anemia within this region with World Bank income level classification of the country. Results: Our findings suggest that the regional prevalence of adolescent anemia and undernutrition remained high at 45% and 19% respectively over the last 20 years. Anemia increased in about one third of countries and undernutrition in about two thirds over the studied period. On the aggregated level, these trends are largely masked and both levels remained stable in the entire region between the years 1998 and 2017. The results of the multivariable regression analysis indicate an association of adolescence with undernutrition and anemia, which was independent of socio-economic factors such as income, education, and place of residence. Conclusion: We conclude that levels of adolescent undernutrition and anemia remain high with little progress over the last 20 years and that adolescence is a significant correlate of both anemia and undernutrition. Given the recognition of the international community that adolescent nutrition is an important public health concern in resource-poor settings, there is an urgent need to improve data availability, quality, and use for decision-making and to design successful high-impact interventions to combat adolescent malnutrition in low- and middle-income countries.


Assuntos
Anemia , Desnutrição , Adolescente , África Central , Anemia/epidemiologia , Feminino , Humanos , Renda , Desnutrição/epidemiologia , Estado Nutricional , Prevalência
13.
J Glob Health ; 11: 13007, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34484714

RESUMO

Background: Adolescence is a formative period when an individual acquires physical, cognitive, emotional, and social resources that are the foundation for later life, health, and well-being [1]. However, in West and Central African region, this trajectory is curtailed by early childbearing associated with an increased risk of undernutrition and anemia. Evidence on socio-economic determinants of anemia and undernutrition in adolescent mothers is limited. This paper aims to shed some light on this issue and, more specifically, assess the socio-economic determinants of anemia among childbearing adolescents in the region. Methods: For this observational study, we pooled data from all Demographic and Health Surveys (DHS) conducted in countries in West and Central Africa region between 1986 and 2017. Outcomes were undernutrition and anemia in adolescent mothers. Predictors were education, wealth, place of residence (rural/urban), and religion. Descriptive statistics were calculated using survey weights for individual surveys and in the pooled sample each country was additionally weighted with its population share. We estimated multiple regression models with and without primary sampling unit fixed effects for both outcomes. All regressions were linear probability models. Results: Having no formal education was the strongest predictor for both anemia and undernutrition. Belonging to the richest asset quintile was also associated with lower anemia and undernutrition prevalence in some specifications. While urban location of the mother was positively associated with anemia, there was no association with undernutrition. Conclusions: Overall, having any formal education emerged as a sole strong predictor of reduced adolescent maternal undernutrition and anemia. Promotion of female education can potentially serve as a high-impact intervention to improve adolescent girls' health in the region. However, we cannot make conclusions about its causal impact based on this study alone.


Assuntos
Anemia , Desnutrição , Adolescente , África Central , Anemia/epidemiologia , Escolaridade , Feminino , Humanos , Desnutrição/epidemiologia , Mães , Prevalência , Fatores Socioeconômicos
14.
Anticancer Res ; 41(9): 4543-4548, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34475081

RESUMO

BACKGROUND/AIM: Adverse event (AE) frequencies observed in interventional clinical trials are difficult to interpret when the placebo control is missing. MATERIALS AND METHODS: Systematic literature review of AEs reported from the placebo arms of randomized cancer trials between 2008 and 2021. Imputation of missing values assuming normal distribution of hemoglobin values. RESULTS: Anemia grade 1 or higher was reported in 46 of 100 placebo monotherapy cohorts with a mean frequency of 23.4% (SD=27%) of the enrolled patients. The reported frequency depended on the type of cancer; other demographic variables had no significant influence on anemia frequency. CONCLUSION: External controls for anemia in clinical trials should be disease specific.


Assuntos
Anemia/epidemiologia , Antineoplásicos/efeitos adversos , Neoplasias/tratamento farmacológico , Adolescente , Adulto , Idoso , Anemia/induzido quimicamente , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ensaios Clínicos Controlados Aleatórios como Assunto , Adulto Jovem
15.
Rinsho Ketsueki ; 62(8): 909-913, 2021.
Artigo em Japonês | MEDLINE | ID: mdl-34497230

RESUMO

Various factors have led to anemia, including a deficiency or excess of trace metals. Copper deficiency, zinc deficiency and lead poisoning are of particular clinical importance. Among them, it should be noted that copper deficiency is increasing due to the use of zinc preparations and the generalization of gastric and intestinal nutrition.


Assuntos
Anemia , Oligoelementos , Anemia/induzido quimicamente , Cobre , Humanos , Zinco
16.
Rinsho Ketsueki ; 62(8): 938-943, 2021.
Artigo em Japonês | MEDLINE | ID: mdl-34497234

RESUMO

Oxygen biology is currently a focus of intensive scientific research. Three scientists received the Nobel prize in physiology or medicine for their outstanding scientific efforts in revealing the mechanisms of oxygen sensing and defense against hypoxia. Hypoxia is a final common pathway to end-stage kidney disease and plays a crucial role in the pathogenesis of cardiovascular complications. Hypoxia-inducible factors (HIFs) are master regulators of defensive mechanisms against hypoxia. Erythropoietin is one of the main targets of HIFs that enhances oxygen delivery by increasing the production of red blood cells. HIF levels are regulated by HIF-prolyl hydroxylase (HIF-PH) inhibitors, which are now available as a new therapeutic modality against anemia in chronic kidney disease. HIF-PH inhibitors raise some theoretical concerns, but should be noted for their potential organ-protective effects.


Assuntos
Anemia , Eritropoetina , Inibidores de Prolil-Hidrolase , Insuficiência Renal Crônica , Anemia/tratamento farmacológico , Anemia/etiologia , Humanos , Hipóxia , Inibidores de Prolil-Hidrolase/uso terapêutico , Insuficiência Renal Crônica/complicações , Insuficiência Renal Crônica/tratamento farmacológico
17.
Trials ; 22(1): 649, 2021 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-34556166

RESUMO

BACKGROUND: Anaemia is a worldwide problem and iron deficiency is the most common cause. In pregnancy, anaemia increases the risk of adverse maternal, foetal and neonatal outcomes. India's anaemia rate is among the highest in the world with India's National Family Health Survey indicating over 50% of pregnant women were affected by anaemia. India's Anaemia Mukt Bharat-Intensified National Iron Plus Initiative aims to reduce the prevalence of anaemia among reproductive-age women, adolescents and children by 3% per year and facilitate the achievement of a Global World Health Assembly 2025 objective to achieve a 50% reduction of anaemia among women of reproductive age. However, preliminary results of the NFHS-5 survey completed in 2020 indicate that anaemia rates are increasing in some states and these targets are unlikely to be achieved. With oral iron being the first-line treatment for iron deficiency anaemia (IDA) in pregnancy, these results are likely to be impacted by the side effects, poor adherence to tablet ingestion and low therapeutic impact of oral iron. These reports suggest a new approach to treating IDA, specifically the importance of single-dose intravenous iron infusions, may be the key to India effectively reaching its targets for anaemia reduction. METHODS: This 3-arm, randomized controlled trial is powered to report two primary outcomes. The first is to assess whether a single dose of two different intravenous formulations administered early in the second trimester of pregnancy to women with moderate IDA will result in a higher percentage of participants achieving a normal for pregnancy Hb concentration at 30-34 weeks' gestation or just prior to delivery when compared to participants taking standard doses of oral iron. The second is a clinical outcome of low birth weight (LBW) (< 2500 g), with a hypothesis that the risk of LBW delivery will be lower in the intravenous iron arms when compared to the oral iron arm. DISCUSSION: The RAPIDIRON trial will provide evidence to determine if a single-dose intravenous iron infusion is more effective and economically feasible in reducing IDA in pregnancy than the current standard of care. TRIAL REGISTRATION: Clinical Trials Registry - India CTRI/2020/09/027730. Registered on 10 September 2020, http://ctri.nic.in/Clinicaltrials/showallp.php?mid1=46801&EncHid=&userName=anemia%20in%20pregnancy.


Assuntos
Anemia Ferropriva , Anemia , Complicações Hematológicas na Gravidez , Adolescente , Anemia Ferropriva/diagnóstico , Anemia Ferropriva/tratamento farmacológico , Anemia Ferropriva/prevenção & controle , Criança , Feminino , Humanos , Recém-Nascido de Baixo Peso , Recém-Nascido , Ferro , Gravidez , Complicações Hematológicas na Gravidez/diagnóstico , Complicações Hematológicas na Gravidez/tratamento farmacológico , Gestantes
18.
JNMA J Nepal Med Assoc ; 59(235): 284-287, 2021 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-34506433

RESUMO

INTRODUCTION: Adolescents comprise individuals in the age group 10 to 19 who are undergoing a period of gradual transition of growth and development. Adolescent girls are at high risk of anemia and malnutrition. This research has been aimed to find the prevalence of anemia in adolescent girls attending specific schools of Panchkhal municipality in Kavrepalanchowk in Nepal. METHODS: A descriptive cross-sectional study was conducted in one government and one private school of Panchkhal Municipality of Kavre district in adolescent girls of age 10 to 19 from December 2017 to April 2018 attending grade five till ten in the field practice area of a medical college. After ethical approval, anthropometric measurements of height, weight, and blood were taken for hemoglobin estimation. Descriptive analysis was done in Microsoft excel 2016. RESULTS: Out of 95 adolescent girls, fourteen (14.74%) adolescent girls were anemic. The mean age was 13.35±1.629 years, mean height and weight were 1.58m and 44.11kg, respectively. CONCLUSIONS: This study shows a lower prevalence of anemia than reported by national data, but it is higher than that reported by developed countries. Anemia and undernutrition have long terms detrimental effects on adolescent girls, so health education and prevention is necessary.


Assuntos
Anemia , Adolescente , Adulto , Anemia/epidemiologia , Criança , Estudos Transversais , Feminino , Humanos , Nepal/epidemiologia , Prevalência , Instituições Acadêmicas , Adulto Jovem
19.
Neurol India ; 69(4): 874-878, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34507404

RESUMO

Context: Plain computed tomography (CT) of the brain is an important first-line investigation of choice in an acute neurologic setup. Unless clinically suspected concealed areas like the confluence of venous sinuses often go unnoticed. Diagnosing anemia, thrombosis, or polycythemia correlating the CT attenuation values might prove to be fruitful in early patient management where the mode of varied clinical presentations causes a clinical dilemma. Aims: 1) To determine the objective correlation between CT attenuation of the cerebral venous sinus and hemoglobin (Hb) as well as hematocrit (HCT) value and 2) to detect anemia from measuring venous sinus attenuation. Methods and Materials: An exploratory study design of 200 patients, who had plain CT of the head and Hb and HCT levels obtained within 24 h of the scan. Statistical Analysis Used: Two-tailed unpaired t-test was used to test the difference between two independent samples. Correlation and regression analyses were used to assess the correlation between two quantitative variables. Results: A significant correlation was observed between the Hb-Hounsfield unit (HU) and HCT-HU. The simple linear regression model revealed that HU (P value < 0.001) was significantly correlated with Hb and the regression model was, Hb = 2.1 + 0.2 × HU. Similarly, HU (P value < 0.001) was significantly correlated with HCT and regression model was HCT = 6.2 + 0.7 × HU. Conclusions: Objective attenuation values of dural sinuses on plain CT can be positively correlated with Hb and HCT values. Considering the cutoff of 35.5 HU, we were able to show the specificity of 100% for the detection of anemia.


Assuntos
Anemia , Cavidades Cranianas , Anemia/diagnóstico por imagem , Encéfalo , Cavidades Cranianas/diagnóstico por imagem , Hematócrito , Humanos , Tomografia Computadorizada por Raios X
20.
JNMA J Nepal Med Assoc ; 59(233): 81-83, 2021 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-34508451

RESUMO

The systemic lupus erythematosus (SLE) is a connective tissue disorder with variable presentations in children. The usual presentation includes arthritis, malar rash, nephritis, hemolytic anemia, and fever. Isolated hematologic abnormality as the only presentation of SLE is rare. Here is a case report of a female child presented to us with superficial and mucosal bleeding with isolated low platelet count and anemia in proportion to blood loss. When platelet count did not go up despite appropriate treatment in lines of ITP, further investigations were done, diagnosis of SLE was established, and management was done accordingly.


Assuntos
Anemia , Artrite , Lúpus Eritematoso Sistêmico , Púrpura Trombocitopênica Idiopática , Criança , Feminino , Humanos , Lúpus Eritematoso Sistêmico/complicações , Lúpus Eritematoso Sistêmico/diagnóstico , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Contagem de Plaquetas , Púrpura Trombocitopênica Idiopática/complicações , Púrpura Trombocitopênica Idiopática/diagnóstico
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