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Nat Mater ; 20(9): 1272-1280, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34112975


DNA is an ultrahigh-density storage medium that could meet exponentially growing worldwide demand for archival data storage if DNA synthesis costs declined sufficiently and if random access of files within exabyte-to-yottabyte-scale DNA data pools were feasible. Here, we demonstrate a path to overcome the second barrier by encapsulating data-encoding DNA file sequences within impervious silica capsules that are surface labelled with single-stranded DNA barcodes. Barcodes are chosen to represent file metadata, enabling selection of sets of files with Boolean logic directly, without use of amplification. We demonstrate random access of image files from a prototypical 2-kilobyte image database using fluorescence sorting with selection sensitivity of one in 106 files, which thereby enables one in 106N selection capability using N optical channels. Our strategy thereby offers a scalable concept for random access of archival files in large-scale molecular datasets.

DNA/química , Armazenamento e Recuperação da Informação , Arquivos , Fluorescência , Plasmídeos , Reação em Cadeia da Polimerase , Dióxido de Silício/química , Biologia Sintética
Stud Health Technol Inform ; 278: 66-74, 2021 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-34042877


Sharing data is of great importance for research in medical sciences. It is the basis for reproducibility and reuse of already generated outcomes in new projects and in new contexts. FAIR data principles are the basics for sharing data. The Leipzig Health Atlas (LHA) platform follows these principles and provides data, describing metadata, and models that have been implemented in novel software tools and are available as demonstrators. LHA reuses and extends three different major components that have been previously developed by other projects. The SEEK management platform is the foundation providing a repository for archiving, presenting and secure sharing a wide range of publication results, such as published reports, (bio)medical data as well as interactive models and tools. The LHA Data Portal manages study metadata and data allowing to search for data of interest. Finally, PhenoMan is an ontological framework for phenotype modelling. This paper describes the interrelation of these three components. In particular, we use the PhenoMan to, firstly, model and represent phenotypes within the LHA platform. Then, secondly, the ontological phenotype representation can be used to generate search queries that are executed by the LHA Data Portal. The PhenoMan generates the queries in a novel domain specific query language (SDQL), which is specific for data management systems based on CDISC ODM standard, such as the LHA Data Portal. Our approach was successfully applied to represent phenotypes in the Leipzig Health Atlas with the possibility to execute corresponding queries within the LHA Data Portal.

Metadados , Software , Arquivos , Fenótipo , Reprodutibilidade dos Testes
Viruses ; 13(4)2021 04 07.
Artigo em Inglês | MEDLINE | ID: mdl-33917139


European bat lyssavirus type 1 (EBLV-1) is the causative agent for almost all reported rabies cases found in European bats. In recent years, increasing numbers of available EBLV-1 full genomes and their phylogenetic analyses helped to further elucidate the distribution and genetic characteristics of EBLV-1 and its two subtypes, namely EBLV-1a and EBLV-1b. Nonetheless, the absence of full-genome sequences from regions with known detections of EBLV-1 still limit the understanding of the phylogeographic relations between viruses from different European regions. In this study, a set of 21 archived Danish EBLV-1 samples from the years 1985 to 2009 was processed for the acquisition of full-genome sequences using a high-throughput sequencing approach. Subsequent phylogenetic analysis encompassing all available EBLV-1 full genomes from databases revealed the Danish sequences belong to the EBLV-1a subtype and further highlighted the distinct, close phylogenetic relationship of Danish, Dutch and German isolates in this region. In addition, the formation of five putative groups nearly exclusively formed by Danish isolates and the overall increased resolution of the EBLV-1a branch indicate a higher genetic diversity and spatial segregation for this sublineage than was previously known. These results emphasize the importance of phylogenetic analyses of full-genome sequences of lyssaviruses for genetic geography.

Quirópteros/virologia , Genoma Viral , Lyssavirus/classificação , Lyssavirus/genética , Filogenia , Raiva/veterinária , Animais , Arquivos , Mapeamento Cromossômico , Segregação de Cromossomos , Dinamarca , Sequenciamento de Nucleotídeos em Larga Escala , Raiva/virologia , Sequenciamento Completo do Genoma
Hist Cienc Saude Manguinhos ; 2828(1): 293-300, 2021.
Artigo em Espanhol | MEDLINE | ID: mdl-33787706


This article aims to provide researchers and students with information on digital archives in libraries in Latin America and elsewhere. It is aimed at those interested in health history, focusing on Peru and Chile.

Arquivos , Bibliotecas Digitais , COVID-19 , Chile , História da Medicina , América Latina , Bibliotecas , Peru
J Med Libr Assoc ; 109(1): 137-140, 2021 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-33424476


For its fifteenth anniversary, the Jay Sexter Library at Touro University Nevada (TUN) sought ways to capture its institutional history by founding an archive. Among many challenges, the library struggled to convince the administration of the importance of an archive. To generate interest in TUN's history, a task force comprising library, executive administration, and advancement staff hosted and recorded a panel event with some of the university's original faculty, staff, and administration. By having this event, new TUN employees were able to experience the shared knowledge of TUN's early days, and the library was able to create and preserve its own institutional history.

Arquivos , Hospitais Universitários/organização & administração , Armazenamento e Recuperação da Informação/normas , Bibliotecas Digitais/organização & administração , Instrução por Computador/normas , Humanos , Universidades
Science ; 370(6517): 712-715, 2020 11 06.
Artigo em Inglês | MEDLINE | ID: mdl-33154141


The Arctic is entering a new ecological state, with alarming consequences for humanity. Animal-borne sensors offer a window into these changes. Although substantial animal tracking data from the Arctic and subarctic exist, most are difficult to discover and access. Here, we present the new Arctic Animal Movement Archive (AAMA), a growing collection of more than 200 standardized terrestrial and marine animal tracking studies from 1991 to the present. The AAMA supports public data discovery, preserves fundamental baseline data for the future, and facilitates efficient, collaborative data analysis. With AAMA-based case studies, we document climatic influences on the migration phenology of eagles, geographic differences in the adaptive response of caribou reproductive phenology to climate change, and species-specific changes in terrestrial mammal movement rates in response to increasing temperature.

Migração Animal , Monitorização de Parâmetros Ecológicos , Aclimatação , Animais , Arquivos , Regiões Árticas , População
PLoS One ; 15(10): e0240123, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33022014


The COVID-19 pandemic has unleashed a deluge of publications. For this cross-sectional study we compared the amount and reporting characteristics of COVID-19-related academic articles and preprints and the number of ongoing clinical trials and systematic reviews. To do this, we searched the PubMed database of citations and abstracts for published life science journals by using appropriate combinations of medical subject headings (MeSH terms), and the COVID-19 section of the MedRxiv and BioRxiv archives up to 20 May 2020 (21 weeks). In addition, we searched, Chinese Clinical Trial Registry, EU Clinical Trials Register, and 15 other trial registers, as well as PROSPERO, the international prospective register of systematic reviews. The characteristics of each publication were extracted. Regression analyses and Z tests were used to detect publication trends and their relative proportions. A total of 3635 academic publications and 3805 preprints were retrieved. Only 8.6% (n = 329) of the preprints were already published in indexed journals. The number of academic and preprint publications increased significantly over time (p<0.001). Case reports (6% academic vs 0.9% preprints; p<0.001) and letters (17.4% academic vs 0.5% preprints; p<0.001) accounted for a greater share of academic compared to preprint publications. Differently, randomized controlled trials (0.22% vs 0.63%; p<0.001) and systematic reviews (0.08% vs 5%) made up a greater share of the preprints. The relative proportion of clinical studies registered at, Chinese Clinical Trial Registry, and EU Clinical Trials Register was 57.9%, 49.5%, and 98.9%, respectively, most of which were still "recruiting". PROSPERO listed 962 systematic review protocols. Preprints were slightly more prevalent than academic articles but both were increasing in number. The void left by the lack of primary studies was filled by an outpour of immediate opinions (i.e., letters to the editor) published in PubMed-indexed journals. Summarizing, preprints have gained traction as a publishing response to the demand for prompt access to empirical, albeit not peer-reviewed, findings during the present pandemic.

Betacoronavirus , Infecções por Coronavirus/epidemiologia , Pneumonia Viral/epidemiologia , Pré-Publicações como Assunto , Editoração , Ensaios Clínicos Controlados Aleatórios como Assunto , Sistema de Registros , Revisões Sistemáticas como Assunto , Arquivos , Bibliometria , Disciplinas das Ciências Biológicas , COVID-19 , Infecções por Coronavirus/virologia , Estudos Transversais , Bases de Dados Factuais , Humanos , Pandemias , Revisão por Pares , Pneumonia Viral/virologia , PubMed , SARS-CoV-2
J Med Libr Assoc ; 108(4): 656-662, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33013228


Since January 30, 2020, when the World Health Organization declared the SARS CoV-2 disease (COVID-19) to be a public health emergency of international concern, the National Library of Medicine's (NLM's) Web Collecting and Archiving Working Group has been collecting a broad range of web-based content about the emerging pandemic for preservation in an Internet archive. Like NLM's other Global Health Events web collections, this content will have enduring value as a multifaceted historical record for future study and understanding of this event. This article describes the scope of the COVID-19 project; some of the content captured from websites, blogs, and social media; collecting criteria and methods; and related COVID-19 collecting efforts by other groups. The growing collection-2,500 items as of June 30, 2020-chronicles the many facets of the pandemic: epidemiology; vaccine and drug research; disease control measures and resistance to them; effects of the pandemic on health care institutions and workers, education, commerce, and many aspects of social life; effects for especially vulnerable groups; role of health disparities in infection and mortality; and recognition of racism as a public health emergency.

Arquivos , Infecções por Coronavirus/epidemiologia , Curadoria de Dados , National Library of Medicine (U.S.) , Pneumonia Viral/epidemiologia , Betacoronavirus , COVID-19 , Coleta de Dados , Saúde Global , Humanos , Pandemias , Controle de Qualidade , SARS-CoV-2 , Estados Unidos
Hist Cienc Saude Manguinhos ; 27(suppl 1): 253-262, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32997066


In the last five years there has been a resurgence of scholarly research and museum exhibitions on the history of HIV and AIDS. This work has called into question some of the conventions of archiving and interpreting the history of the pandemic. It is increasingly clear that a narrow range of materials have been saved. As historians and curators turn to these holdings for analysis and exhibition, they find they inadequately represent the impact of AIDS across diverse groups as well as the range of local, national, international responses. This essay considers some of the factors that shape collection of the material culture, particularly the heritage of public health, and the consequences for our understanding of lessons from the past.

Síndrome de Imunodeficiência Adquirida/história , Arquivos , Infecções por HIV/história , Museus , Saúde Pública/história , Feminino , Infecções por HIV/transmissão , História do Século XX , História do Século XXI , Homossexualidade Masculina/história , Humanos , Masculino
RECIIS (Online) ; 14(3): 764-781, jul.-set. 2020.
Artigo em Português | LILACS | ID: biblio-1122123


Este estudo realiza uma reflexão sobre a preservação de documentos arquivísticos digitais em uma perspectiva sistêmica, pautada em padrões reconhecidos pela literatura científica. De tal forma, utiliza-se da visão holística para ressaltar a pertinência da preservação ser pensada em todo o ciclo de vida dos documentos. A metodologia parte do levantamento bibliográfico composto por artigos, livros e publicações técnicas, para assim, obter uma revisão narrativa. Ressalta-se que a preservação digital tem evoluído para novos patamares e requer o uso de padrões para implementar sistemas informatizados confiáveis. Com isso, pode-se envolver todo o ciclo vital em uma cadeia de custódia ininterrupta capaz de assegurar a autenticidade dos documentos digitais. Por fim, defende-se uma abordagem sistêmico-holística, em que os documentos são planejados e produzidos tendo em vista a preservação e o acesso em longo prazo.

This study reflects on the preservation of digital archival records from a systemic perspective, based on standards recognized by scientific literature. In such a way, it uses a holistic view to emphasize the relevance of preservation to be considered throughout the life cycle of records. The methodology is based on a bibliographic survey composed of articles, books, and technical publications, to obtain a narrative review. It is noteworthy that digital preservation has evolved to new heights, and requires the use of standards to implement reliable computer systems. With this, the entire life cycle can be involved in an uninterrupted chain of custody capable of ensuring the authenticity of digital records. Finally, a systemic-holistic approach is advocated, in which records are planned and produced with a view of the preservation and access in the long-term.

Este estudio reflexiona sobre la preservación de los documentos de archivo digital en una perspectiva sistémica, basada en normas y estándares reconocidos por la literatura científica. De esta manera, utiliza la visión holística para enfatizar la relevancia de la preservación a ser considerada a lo largo del ciclo de vida de los documentos. La metodología se basa en una encuesta bibliográfica compuesta de artículos, libros y publicaciones técnicas, para obtener una revisión narrativa. Es de destacar que la preservación digital ha evolucionado a nuevas alturas y requiere el uso de estándares para implementar sistemas informáticos confiables. Con esto, todo el ciclo de vida puede involucrarse en una cadena de custodia ininterrumpida capaz de garantizar la autenticidad de los documentos digitales. Finalmente, se aboga por un enfoque holístico-sistémico, en que los documentos se planifican y producen con miras la preservación y acceso a largo plazo.

Humanos , Arquivos , Sistemas de Informação , Registros , Gestão da Informação , Curadoria de Dados , Coleta de Dados , Armazenamento e Recuperação da Informação , Acesso à Informação
RECIIS (Online) ; 14(3): 546-562, jul.-set. 2020. ilus, graf
Artigo em Português | LILACS | ID: biblio-1121410


Este artigo possui como objetivo identificar ações governamentais no âmbito dos sistemas e serviços de saúde que visam a adoção de políticas públicas relacionadas à preservação digital em saúde. As políticas públicas de informação e de arquivos são transversais às políticas públicas de saúde e contribuem diretamente para a garantia dos direitos dos cidadãos preconizados pelo Sistema Único de Saúde (SUS). Neste sentido, as políticas de preservação digital são essenciais para garantir o acesso às informações a gerações futuras. A pesquisa caracteriza-se como aplicada e exploratória. Utiliza como amostra os textos completos da Consolidação das Normas Infralegais do SUS. Os resultados apontam para a necessidade de ações voltadas para a preservação digital em saúde por meio da adoção de políticas públicas. Por fim, destaca-se que a participação popular no desenvolvimento destas políticas públicas de informação em saúde é essencial para a transparência das ações governamentais.

This article seeks to identify governmental actions within the scope of health systems and services that aim to adopt public policies related to digital preservation in health. Public information and archive policies are transversal to public health policies and directly contribute to guaranteeing the rights of citizens advocated by the Unified Health System (SUS). In this sense, digital preservation policies are essential to guarantee access to information for future generations. The research is characterized as applied and exploratory. It uses as a sample the complete texts of the Consolidation of Infralegal Norms of SUS. The results point to the need for actions aimed at digital preservation in health through the adoption of public policies. Finally, it is emphasized that popular participation in the development of these public health information policies is essential for the transparency of governmental actions.

Este artículo tiene como objetivo identificar acciones gubernamentales dentro del alcance de los sistemas y servicios de salud que apuntan a adoptar políticas públicas relacionadas con la preservación digital en salud. Las políticas de información pública y archivo son transversales a las políticas de salud pública y contribuyen directamente a garantizar los derechos de los ciudadanos que defiende el Sistema Único de Salud (SUS). En este sentido, las políticas de preservación digital son esenciales para garantizar el acceso a la información para las generaciones futuras. La investigación se caracteriza por ser aplicada y exploratoria. Utiliza como muestra los textos completos de la Consolidación de las Normas Infralegales del SUS. Los resultados apuntan a la necesidad de acciones dirigidas a la preservación digital en salud a través de la adopción de políticas públicas. Finalmente, se enfatiza que la participación popular en el desarrollo de estas políticas de información de salud pública es esencial para la transparencia de las acciones gubernamentales.

Humanos , Arquivos , Política Pública , Sistema Único de Saúde , Segurança Computacional , Comunicação em Saúde , Brasil , Gestão da Informação , Acesso à Informação
RECIIS (Online) ; 14(3): 580-596, jul.-set. 2020. ilus
Artigo em Português | LILACS | ID: biblio-1121772


Este artigo apresenta uma proposta de modelagem conceitual da cadeia de custódia para os Registros Eletrônicos em Saúde (RES). O interesse em conhecer os critérios de autenticidade dos RES encaminhados dos serviços até o Portal do DATASUS gerou esta investigação. A pesquisa é exploratória e descritiva por meio de uma revisão sistemática da literatura e documental para prospecção e análise sobre autenticidade e preservação dos RES. A partir dos resultados encontrados foram identificados os custodiadores e a proposta de modelagem da cadeia de custódia para o Sistema Único de Saúde (SUS). Espera-se que os custodiadores modelados assimilem subsídios para a criação de repositórios digitais em saúde confiáveis e recomenda-se a adoção e a incorporação dos processos de gestão arquivística de documentos articulados com os da TI.

This article presents a proposal of conceptual modeling of the chain of custody for Electronic Health Records (EHR). The curiosity to know the authenticity criteria of the EHR sent from the services to the DATASUS Portal generated this investigation. The research is both exploratory and descriptive by means of a systemic literature and documental review for the prospection and analysis on authenticity and preservation of the EHR. According to the results found, the custodians and the proposal of custody chain modeling for Unified Health System (SUS) were identified. The modeled custodians are expected to assimilate subsidies for the creation of reliable digital health repositories. It is recommended that they adopt and incorporate the articulated processes of archival management to those from the IT.

Este artículo presenta una propuesta de modelado conceptual de la cadena de custodia para Registros Electrónicos en Salud (RES). La curiosidad por conocer los criterios de autenticidad de los RES enviados desde los servicios hacia el Portal DATASUS generó esta investigación. La investigación es exploratoria y descriptiva a través de una revisión sistemática de literatura y documental para la prospección y análisis de autenticidad y preservación de los RES. A partir de los resultados encontrados, se identificaron los custodios y la propuesta de modelado de la cadena de custodia para el Sistema Único de Salud (SUS). Se espera que los custodios modelados asimilen los subsidios para la creación de repositorios digitales en salud confiables y se recomienda la adopción e incorporación de los procesos de gestión de archivos de documentos articulados con los de TI.

Humanos , Arquivos , Sistema Único de Saúde , Registros , Registros Eletrônicos de Saúde , Gestão da Informação em Saúde , Tecnologia da Informação , Arquivamento , Revisão Sistemática
Hist. ciênc. saúde-Manguinhos ; 27(supl.1): 253-262, Sept. 2020.
Artigo em Inglês | LILACS | ID: biblio-1134093


Abstract In the last five years there has been a resurgence of scholarly research and museum exhibitions on the history of HIV and AIDS. This work has called into question some of the conventions of archiving and interpreting the history of the pandemic. It is increasingly clear that a narrow range of materials have been saved. As historians and curators turn to these holdings for analysis and exhibition, they find they inadequately represent the impact of AIDS across diverse groups as well as the range of local, national, international responses. This essay considers some of the factors that shape collection of the material culture, particularly the heritage of public health, and the consequences for our understanding of lessons from the past.

Resumo Nos últimos cinco anos, retomaram-se as pesquisas acadêmicas e exposições museológicas sobre a história do HIV e da aids. Este trabalho questiona algumas das convenções de arquivamento e interpretação da história da pandemia. Fica cada vez mais claro que foi preservada uma pequena amostra de materiais. À medida que historiadores e curadores recorrem a esse patrimônio para análise e exposição, descobrem que representam de maneira inadequada o impacto da aids em diversos grupos, bem como o escopo das respostas locais, nacionais e internacionais. Este artigo considera alguns dos fatores que influenciam a coleção de cultura material, em particular o legado da saúde pública e as consequências de nossa compreensão das lições do passado.

Humanos , Masculino , Feminino , História do Século XX , História do Século XXI , Arquivos , Infecções por HIV/história , Saúde Pública/história , Síndrome de Imunodeficiência Adquirida/história , Museus , Infecções por HIV/transmissão , Homossexualidade Masculina/história
Science ; 369(6507)2020 08 28.
Artigo em Inglês | MEDLINE | ID: mdl-32855310


Strategies for 21st-century environmental management and conservation under global change require a strong understanding of the biological mechanisms that mediate responses to climate- and human-driven change to successfully mitigate range contractions, extinctions, and the degradation of ecosystem services. Biodiversity responses to past rapid warming events can be followed in situ and over extended periods, using cross-disciplinary approaches that provide cost-effective and scalable information for species' conservation and the maintenance of resilient ecosystems in many bioregions. Beyond the intrinsic knowledge gain such integrative research will increasingly provide the context, tools, and relevant case studies to assist in mitigating climate-driven biodiversity losses in the 21st century and beyond.

Biodiversidade , Mudança Climática/história , Conservação dos Recursos Naturais , Extinção Biológica , Animais , Arquivos , História Antiga , Paleontologia
Ned Tijdschr Geneeskd ; 1642020 07 23.
Artigo em Holandês | MEDLINE | ID: mdl-32779933


The introduction of penicillin to medical practice in the Netherlands is closely related to the liberation of the Netherlands from Nazi occupation. The allied forces brought penicillin - of which they had vast quantities - to the Netherlands and introduced it to Dutch doctors. In many of the oldest documented cases involving the use of penicillin in the Netherlands, allied army doctors gave the ampoules of penicillin to Dutch doctors, who used the until then unknown medicine as a last-resort drug to treat patients with severe infections that had failed to respond to other treatments. The archives of the Dutch Journal of Medicine (NTvG) contain numerous interesting examples of case reports. A public call on the website of the Dutch public news broadcaster NOS resulted in several other apt examples. It is, however, not known exactly who the first Dutch patient to receive penicillin was.

Antibacterianos/história , Doenças Transmissíveis/história , Penicilinas/história , Arquivos , Doenças Transmissíveis/tratamento farmacológico , História do Século XX , Humanos , Países Baixos , Publicações Periódicas como Assunto
PLoS One ; 15(8): e0233455, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32760066


This study focuses on the use and users of Finnish social science research data archive. Study is based on enriched user data of the archive from years 2015-2018. Study investigates the number and type of downloaded datasets, the number of citations for data, the demographics of data downloaders and the purposes data are downloaded for. Datasets were downloaded from the archive 10346 times. Majority of the downloaded datasets are quantitative. Quantitative datasets are also more often cited, but the number of citations vary and does not always correlate with the number of downloads. Use of the archive varies by user's country, organization, and discipline. Datasets from the archive were downloaded most often for study work, bachelor's and master's theses, and research purposes. It is likely that reusing research data will increase in the near future as more data will become available, scholars are more informed about research data management, and data citation practices are established.

Ciências Sociais , Arquivos , Bases de Dados Factuais , Finlândia , Humanos , Disseminação de Informação , Pesquisa/estatística & dados numéricos , Ciências Sociais/estatística & dados numéricos
Anal Biochem ; 604: 113824, 2020 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-32649932


The margins of several pages of the Aleppo codex have been found to be corroded and contaminated by diffuse maculae. In order to understand the origin of this decay these margins have been analysed by applying EVA (ethylene vinyl acetate plastic embedded with strong cation and anion exchangers and mixed with C8 and C18 hydrophobic resins) diskettes for harvesting surface material. The captured compounds have been eluted, digested with trypsin and analysed by nano-HPLC-MS. Three major strains of Aspergillus have been identified, namely Aspergillus fumigatus, Aspergillus pseudoglaucus, Aspergillus amstelodami, together with a lactobacillus strain and human keratins. The novelty of this investigation is that for the first time the EVA technology has been applied to ancient parchments in the absence of mechanical deformation or distortion that could be induced if there had been water exchange between the EVA diskettes and the parchment. These findings should help curators to find suitable restoration protocols for these precious documents belonging to the world Cultural Heritage.

Aspergillus/isolamento & purificação , Queratinas/isolamento & purificação , Lactobacillus/isolamento & purificação , Arquivos/história , História Antiga , Polivinil/química
Br Dent J ; 229(1): 54-59, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32651523


This article scrutinises the life and work of the German caries researcher Carl Röse (1864-1947) - the first known dentist to be nominated for the Nobel Prize in physiology or medicine. The starting point of the paper is Röse's curriculum vitae. The analysis then focuses on Röse's research on cariology, which led to his nomination, as well as the nomination itself. Further attention is given to Röse's other research interests, in particular his 'race studies' and his role in the 'Third Reich'. The paper is based on numerous contemporary primary sources, such as documents collected in the archive of the Nobel Committee for Physiology or Medicine in Solna, Sweden, as well as a critical re-analysis of secondary literature on Carl Röse and on the history of cariology and 'racial research'. It leads to the conclusion that Röse made significant contributions to the study of caries. Röse's study design can be regarded as a precursor of today's multi-centre studies. Nevertheless, the nomination remained a singular one. Moreover, it can be shown that Röse received special attention due to his pronounced racist views in the 'Third Reich'; this culminated in his being awarded the Miller Prize and the Goethe Medal presented by Hitler. Röse died after the collapse of the 'Third Reich' as a largely forgotten man.

Medicina , Prêmio Nobel , Arquivos , Odontólogos , História do Século XX , Humanos , Suécia