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1.
Iran J Allergy Asthma Immunol ; 21(2): 128-140, 2022 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-35490267

RESUMO

Alternative medicine, has become popular in asthmatic patients. We evaluated the immunomodulatory effects of SINA 1.2 therapy protocol derived from Persian medicine in an asthmatic mice model. Forty-two male BALB/c mice divided into six groups: one control (sham) and five sensitized groups (by parenteral injection of 20 µg ovalbumin in 100 µL normal saline plus 50 µL alum on days 1 and 14). Sensitized groups were as: untreated, budesonide (1 mg nebulized budesonide: 200 µg/puff every 5 min for 25 min), dry sauna (30 min, 37°C), oral oxymel (gavaged: 0.2 mL of the syrup plus 0.8 mL of water), and SINA protocol No.1.2 (oxymel followed by sauna) groups. Treatments were given for 10 days from day 23 to 33 then sacrificed. Significant gene expression reduction of interleukin(IL)-4, IL-5, and MUC5AC and increase of interferon(IFN)-γ and IFN-γ/IL-4 ratio and decreased perivascular and peribronchial inflammation, goblet cell hyperplasia, and subsequent mucus hypersecretion in SINA group were seen compared to untreated group. SINA lowered IL-5 and MUC5AC gene expression levels similar to the budesonide and acted better than budesonide in increasing IFN-γ gene expression up to normal level. Compared with the asthma group, sauna alone only affected MUC5AC and IFN-γ gene expressions and oxymel alone, only reduced IL-4 gene expression, perivascular and peribronchial inflammation, and mucus hypersecretion. It seems that SINA therapy alleviates asthma via immune modulation of pro-inflammatory cytokines and improvement of pathological changes in ovalbumin-induced asthma in mice, supporting the notion of innate healing power mentioned in Persian medicine literature.


Assuntos
Asma , Banho a Vapor , Animais , Budesonida/efeitos adversos , Humanos , Inflamação , Interleucina-4/metabolismo , Interleucina-5/efeitos adversos , Interleucina-5/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Ovalbumina
2.
Neurobiol Aging ; 113: 118-130, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-35334439

RESUMO

In Alzheimer's disease (AD), hyper-phosphorylation and aggregation of tau correlate with clinical progression and represent a valid therapeutic target. A recent 20-year prospective study revealed an association between moderate to high frequency of Finnish sauna bathing and a lower incidence of dementia and AD, but the molecular mechanisms underlying these benefits remain uncertain. Here, we tested the hypothesis that sauna-like conditions could lower tau phosphorylation by increasing body temperature. We observed a decrease in tau phosphorylation in wild-type and hTau mice as well as in neuron-like cells when exposed to higher temperatures. These effects were correlated with specific changes in phosphatase and kinase activities, but not with inflammatory or heat shock responses. We also used a drug strategy to promote thermogenesis: topical application of menthol, which led to a sustained increase in body temperature in hTau mice, concomitant with a significant decrease in tau phosphorylation. Our results suggest that sauna-like conditions or menthol treatment could lower tau pathology through mild hyperthermia, and may provide promising therapeutic strategies for AD and other tauopathies.


Assuntos
Doença de Alzheimer , Banho a Vapor , Tauopatias , Doença de Alzheimer/patologia , Animais , Mentol , Camundongos , Fosforilação , Estudos Prospectivos , Tauopatias/patologia , Proteínas tau/metabolismo
5.
Scand J Urol ; 56(1): 77-82, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34783288

RESUMO

OBJECTIVE: To evaluate the effect of sauna bathing on lower urinary tract symptoms (LUTS) in a Finnish population-based cohort. METHODS: A mail survey was sent to a population-based cohort of 50-, 60-, and 70-year-old men in 1994 followed by repeat questionnaires in 1999 and 2004. The evaluation of ten different types of LUTS was based on Danish Prostatic Symptom Score (DAN-PSS-1). The weekly frequency of sauna bathing was assessed in the first questionnaire and divided into three subgroups (0-1, 2, and ≥3). The prevalence, incidence, and remission rate of each LUTS was assessed based on the initial and follow-up assessments. In addition, the mean DAN-PSS-1 symptoms score, medication for LUTS, and operative treatment were determined at each time-point. Chi-square test, a linear-by-linear test, and binary logistic regression analysis were used to assess statistical significance. RESULTS: The population-based cohort included initially 3,163, men of whom 1,306 (41.3%) responded to all three questionnaire rounds and were included in the analysis. There was no clear association between sauna bathing frequency and prevalence of the nine LUTS, nor with incidence and remission rates. The only exception was feelings of incomplete emptying, with lower prevalence associated with frequent sauna bathing. There were no clear differences in the medications or operations for LUTS by sauna bathing habits. CONCLUSION: Based on our results, sauna bathing does not affect LUTS development or natural history in the long-term.


Assuntos
Sintomas do Trato Urinário Inferior , Banho a Vapor , Tamus , Envelhecimento , Hábitos , Humanos , Sintomas do Trato Urinário Inferior/epidemiologia , Sintomas do Trato Urinário Inferior/etiologia , Sintomas do Trato Urinário Inferior/terapia , Masculino , Inquéritos e Questionários
6.
J Cardiopulm Rehabil Prev ; 42(1): 59-63, 2022 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-33797457

RESUMO

PURPOSE: Inflammatory pathways are involved in the pathogenesis of pneumonia. Frequent sauna sessions may reduce the risk of respiratory tract infections including pneumonia independent of inflammation. We aimed to evaluate the independent and joint associations of high-sensitivity C-reactive protein (hsCRP) and frequency of sauna bathing (FSB) with risk of pneumonia in a prospective cohort study. METHODS: Serum hsCRP as an inflammatory marker was measured using an immunometric assay and FSB was assessed by self-reported sauna bathing habits at baseline in 2264 men aged 42-61 yr. Serum hsCRP was categorized as normal and high (≤3 and >3 mg/L, respectively) and FSB as low and high (defined as ≤1 and 2-7 sessions/wk, respectively). Multivariable-adjusted HRs (CIs) were calculated for incident pneumonia. RESULTS: A total of 528 cases of pneumonia occurred during a median follow-up of 26.6 yr. Comparing high versus normal hsCRP, the multivariable-adjusted risk for pneumonia was HR = 1.30 (95% CI, 1.04-1.62). The corresponding risk was HR = 0.79 (95% CI, 0.66-0.95) comparing high versus low FSB. Compared with men with normal hsCRP and low FSB, high hsCRP and low FSB was associated with an increased risk of pneumonia in multivariable analysis (HR = 1.67: 95% CI, 1.21-2.29), with no evidence of an association for high hsCRP and high FSB and pneumonia (HR = 0.94: 95% CI, 0.69-1.29). CONCLUSIONS: In a general middle-aged to older male Caucasian population, frequent sauna baths attenuated the increased risk of pneumonia due to inflammation.


Assuntos
Pneumonia , Banho a Vapor , Banhos , Proteína C-Reativa , Humanos , Inflamação , Masculino , Pessoa de Meia-Idade , Pneumonia/epidemiologia , Pneumonia/etiologia , Pneumonia/prevenção & controle , Estudos Prospectivos , Fatores de Risco , Banho a Vapor/efeitos adversos
7.
Complement Ther Med ; 64: 102798, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34954348

RESUMO

BACKGROUND: Passive heat therapies have been reported to have similar effects on the cardiovascular system as exercise. Studies supporting these findings in healthy populations have predominantly been done with men using warm water immersions or traditional saunas, rather than newer infrared-based saunas. OBJECTIVE: To explore short-term thermal and cardiovascular responses in women using an infrared sauna as compared to moderate-intensity exercise. STUDY DESIGN: Randomized controlled crossover trial with balanced allocations. SETTING: Brisbane, Australia (August 2019 - March 2020) PARTICIPANTS: Ten healthy women (36 ±â€¯9 years) INTERVENTIONS: 45 min of resting, infrared sauna or indoor bicycling PRIMARY OUTCOME MEASURES: tympanic/skin temperatures; respiratory rate; blood pressure; arterial stiffness; heart rate variability RESULTS: Tympanic temperatures were elevated during infrared sauna as compared to both control (mean diff = +1.05 oC ±â€¯SEM 0.12 oC, 95% C.I.: 0.73 - 1.36, p < 0.0005) and exercise (mean diff = +0.79 oC ±â€¯SEM 0.12 oC, 95% C.I.: 0.49 - 1.08, p < 0.0005). Respiratory rates were higher during exercise as compared to both control (mean diff = +7.66 ±â€¯SEM 1.37, 95% C.I.: 4.09 - 11.23, p < 0.0005) and infrared sauna (mean diff = +6.66 ±â€¯SEM 1.33, 95% C.I.: 3.20 - 10.11, p < 0.0005). No significant differences in non-invasive measures of blood pressure, arterial stiffness or heart rate variability were detected between any of the interventions. CONCLUSIONS: These findings suggest the physiological effects of infrared sauna bathing are underpinned by thermoregulatory-induced responses, more so than exercise-mimetic cardiorespiratory or cardiovascular activations.


Assuntos
Banho a Vapor , Pressão Sanguínea , Estudos Cross-Over , Exercício Físico , Feminino , Frequência Cardíaca , Humanos , Masculino
8.
Artigo em Inglês | MEDLINE | ID: mdl-34769872

RESUMO

In combat sports, competitors are separated into weight divisions, to create equality between the athletes. Consequently, rapid weight loss (RWL) is a common practice in combat sports. Although the methods used to induce RWL are similar among athletes, currently, there are limited data concerning the RWL methodologies used by sambo athletes. Therefore, this study aimed at determining RWL procedures among female sambo athletes. Participants in the study were top-level athletes competing at the World Sambo Championship held in Novi Sad. A total sample of 47 female sambo athletes, of whom 24 were seniors (27.3 ± 4 year/age, 1.61 ± 0.09 m/height, 61.8 ± 8.87 kg/weight) and 23 juniors (18.7 ± 0.8 year/age, 1.66 ± 0.07 m/height, 63.7 ± 12.1 kg/weight), were examined in the study. To determine RWL methods, data were collected through a standardized questionnaire. As a result, 88.7% of the female sambo athletes declared that they intentionally cut their weight before the competition. The most commonly used methods were gradual dieting, followed by sauna, fluid restriction, and skipping meals. The most considerable influence on the RWL strategies of athletes came from coaches and personal trainers, while physicians and dietitians were far less influential. The results obtained from this representative sample highlight the most common practices concerning weight cutting prior to competition among females. Therefore, there is a need to inform and educate both athletes and coaches about the potentially harmful effects of RWL in combat sports.


Assuntos
Artes Marciais , Banho a Vapor , Atletas , Feminino , Humanos , Lactente , Inquéritos e Questionários , Perda de Peso
9.
Artigo em Inglês | MEDLINE | ID: mdl-34770018

RESUMO

The aim of this study was to determine the effects of thermal stress (TS) on changes in blood biochemical parameters and fluid electrolyte levels in young adult men with moderate and high levels of physical activity. Thirty men (22.67 ± 2.02 years) were exposed to four 12-min sauna sessions (temperature: 90-91 °C; relative humidity: 14-16%) with four 6-min cool-down breaks. The evaluated variables were anthropometric, physiological, and hematological characteristics. The mean values of HRavg (102.5 bpm) were within the easy effort range, whereas HRpeak (143.3 bpm) values were within the very difficult effort range. A significant increase was noted in pO2 (p < 0.001), total cholesterol (p < 0.008), HDL (p < 0.006) and LDL cholesterol (p < 0.007). Significant decreases were observed in the SBP (by 9.7 mmHg), DBP (by 6.9 mmHg) (p < 0.001), pH (p < 0.001), aHCO3- (p < 0.005), sHCO3- (p < 0.003), BE (ecf) (p < 0.022), BE (B), ctCO2 (for both p < 0.005), glucose (p < 0.001), and LA (p < 0.036). High 72-min TS did not induce significant changes in the physiological parameters of young and physically active men who regularly use the sauna, excluding significant loss of body mass. We can assume that relatively long sauna sessions do not disturb homeostasis and are safe for the health of properly prepared males.


Assuntos
Banho a Vapor , Antropometria , Temperatura Corporal , Exercício Físico , Humanos , Masculino , Banho a Vapor/efeitos adversos , Temperatura , Adulto Jovem
10.
J Environ Radioact ; 240: 106761, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34755607

RESUMO

A high throughput system for processing and detection of low levels of radioxenon in soil gas samples has been developed. Processing and analysis of sub-soil noble gas samples puts high demands on the gas separation part of the system since the samples might contain high levels of Rn, CO2 as well as other gases. The gas process is optimized to remove all CO2, H2O and Rn with a high recovery yield of the xenon in the sample to ensure a high sensitivity even for small samples. The system is designed to handle multiple samples per day with a high level of automation and sample traceability to be suitable for use in an on-site inspection (OSI) an important component in the verification of the Comprehensive Nuclear Test Ban Treaty. To ensure a rapid deployment the system could be pre-installed in a flight container.


Assuntos
Poluentes Radioativos do Ar , Monitoramento de Radiação , Banho a Vapor , Poluentes Radioativos do Ar/análise , Gases , Solo , Radioisótopos de Xenônio/análise
12.
J Therm Biol ; 100: 103048, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34503795

RESUMO

This manuscript aims to evaluate the influence of a novel passive heat acclimation program among human participants in the physical performance, as well as in several physiological parameters. 36 male football players were acclimated using a dry sauna bath to extreme hot (100 ± 3 °C), performing a total of nine sauna sessions with a weekly frequency of three sessions. The players were randomly into the sauna group (SG; n = 18; age: 20.69 ± 2.09 years) and the control group (CG; n = 18; age: 20.23 ± 1.98 years). All participants performed maximal effort test until exhaustion as well as hamstring flexibility test before and after the acclimation program. Anthropometric, respiratory, circulatory, hematological and physiological variables were evaluated at the beginning and at the end of the survey. Statistical analysis consisted of a Mann-Whitney U test to determine differences between groups at the beginning and at the end of the survey and a Wilcoxon test for paired samples to compare the differences for each group separately. Additionally, size effects of the pre-post acclimation changes were calculated. After the acclimation program SG participants experienced a diminution in body weight (p < 0.01), body mass index (p < 0.01), body fat (p < 0.05) and fat percentage (p < 0.05) decreased. Hamstring flexibility (p < 0.05) and work capacity (p < 0.05) increased. External basal temperature decreased (p < 0.05) as well as post-exercise systolic and diastolic blood pressures (p < 0.05). Finally, maximal oxygen uptake (ml Kg-1 min-1) (p < 0.05), maximal minute ventilation (p < 0.05) and maximal breath frequency (p < 0.05) increased at the end of the intervention. There were no significant changes in the CG in any variable. Favorable adaptations have been observed in this survey, suggesting a beneficial effect of extreme heat acclimation on physical performance. Several of the observed responses seem interesting for sport performance and health promotion as well. However, this is a novel, extreme protocol which requires further research.


Assuntos
Aclimatação , Desempenho Atlético , Futebol Americano/fisiologia , Banho a Vapor/métodos , Adolescente , Temperatura Corporal , Humanos , Masculino , Consumo de Oxigênio , Condicionamento Físico Humano/métodos , Adulto Jovem
13.
Exp Gerontol ; 154: 111509, 2021 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-34363927

RESUMO

Sauna use, sometimes referred to as "sauna bathing," is characterized by short-term passive exposure to high temperatures, typically ranging from 45 °C to 100 °C (113 °F to 212 °F), depending on modality. This exposure elicits mild hyperthermia, inducing a thermoregulatory response involving neuroendocrine, cardiovascular, and cytoprotective mechanisms that work in a synergistic fashion in an attempt to maintain homeostasis. Repeated sauna use acclimates the body to heat and optimizes the body's response to future exposures, likely due to the biological phenomenon known as hormesis. In recent decades, sauna bathing has emerged as a probable means to extend healthspan, based on compelling data from observational, interventional, and mechanistic studies. Of particular interest are the findings from large, prospective, population-based cohort studies of health outcomes among sauna users that identified strong dose-dependent links between sauna use and reduced morbidity and mortality. This review presents an overview of sauna practices; elucidates the body's physiological response to heat stress and the molecular mechanisms that drive the response; enumerates the myriad health benefits associated with sauna use; and describes sauna use concerns.


Assuntos
Banho a Vapor , Regulação da Temperatura Corporal , Resposta ao Choque Térmico , Humanos , Estilo de Vida , Estudos Prospectivos
14.
Artigo em Inglês | MEDLINE | ID: mdl-34199101

RESUMO

The influence of a series of ten sauna baths (MPHA) on thermophysiological and selected hematological responses in 14 elite cross-country skiers to a submaximal endurance exercise test performed under thermoneutral environmental conditions was studied. Thermal and physiological variables were measured before and after the exercise test, whereas selected hematological indices were studied before, immediately after, and during recovery after a run, before (T1) and after sauna baths (T2). MPHA did not influence the baseline internal, body, and skin temperatures. There was a decrease in the resting heart rate (HR: p = 0.001) and physiological strain (PSI: p = 0.052) after MPHA and a significant effect of MPHA on systolic blood pressure (p = 0.03), hematological indices, and an exercise effect but no combined effect of treatments and exercise on the tested variables. A positive correlation was reported between PSI and total protein (%ΔTP) in T2 and a negative between plasma volume (%ΔPV) and mean red cellular volume (%ΔMCV) in T1 and T2 in response to exercise and a positive one during recovery. This may suggest that MPHA has a weak influence on body temperatures but causes a moderate decrease in PSI and modifications of plasma volume restoration in response to exercise under temperate conditions in elite athletes.


Assuntos
Banho a Vapor , Aclimatação , Exercício Físico , Frequência Cardíaca , Temperatura Alta , Humanos , Volume Plasmático
17.
Sci Rep ; 11(1): 15514, 2021 07 30.
Artigo em Inglês | MEDLINE | ID: mdl-34330970

RESUMO

The intestinal barrier plays a crucial role in maintaining gut health, and an increased permeability has been linked to several intestinal and extra-intestinal disorders. There is an increasing demand for interventions aimed at strengthening this barrier and for in vivo challenge models to assess their efficiency. This study investigated the effect of sauna-induced dehydration on intestinal barrier function (clinicaltrials.gov: NCT03620825). Twenty healthy subjects underwent three conditions in random order: (1) Sauna dehydration (loss of 3% body weight), (2) non-steroidal anti-inflammatory drug (NSAID) intake, (3) negative control. Intestinal permeability was assessed by a multi-sugar urinary recovery test, while intestinal damage, bacterial translocation and cytokines were assessed by plasma markers. The sauna dehydration protocol resulted in an increase in gastroduodenal and small intestinal permeability. Presumably, this increase occurred without substantial damage to the enterocytes as plasma intestinal fatty acid-binding protein (I-FABP) and liver fatty acid-binding protein (L-FABP) were not affected. In addition, we observed significant increases in levels of lipopolysaccharide-binding protein (LBP), IL-6 and IL-8, while sCD14, IL-10, IFN-É£ and TNF-α were not affected. These results suggest that sauna dehydration increased intestinal permeability and could be applied as a new physiological in vivo challenge model for intestinal barrier function.


Assuntos
Banho a Vapor , Proteínas de Fase Aguda/metabolismo , Adulto , Anti-Inflamatórios não Esteroides , Pesquisa Biomédica , Proteínas de Transporte/metabolismo , Proteínas de Ligação a Ácido Graxo/metabolismo , Feminino , Humanos , Interleucina-10/metabolismo , Interleucina-6/metabolismo , Fígado/metabolismo , Masculino , Glicoproteínas de Membrana/metabolismo , Temperatura , Fator de Necrose Tumoral alfa/metabolismo , Adulto Jovem
19.
Am J Mens Health ; 15(2): 15579883211008339, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33845653

RESUMO

The aim of the study was to determine the effect of repeated hot thermal stress and cold water immersion on the endocrine system of young adult men with moderate and high levels of physical activity (PA). The research was conducted on 30 men aged 19-26 years (mean: 22.67 ± 2.02) who attended four sauna sessions of 12 min each (temperature: 90-91°C; relative humidity: 14-16 %). Each sauna session was followed by a 6-min cool-down break during which the participants were immersed in cold water (10-11°C) for 1 min. Testosterone (TES), cortisol (COR), dehydroepiandrosterone sulfate (DHEA-S), and prolactin (PRL) levels were measured before and after the sauna bath. The participants' PA levels were evaluated using the International Physical Activity Questionnaire. Serum COR levels decreased significantly (p < .001) from 13.61 to 9.67 µg/ml during 72 min of sauna treatment. No significant changes (p >.05) were noted in the concentrations of the remaining hormones: TES increased from 4.04 to 4.24 ng/ml, DHEA-S decreased from 357.5 to 356.82 µg/ml, and PRL decreased from 14.50 to 13.71 ng/ml. After sauna, a greater decrease in COR concentrations was observed in males with higher baseline COR levels, whereas only a minor decrease was noted in participants with very low baseline COR values (r =-0.673, p <.001). Repeated use of Finnish sauna induces a significant decrease in COR concentrations, but does not cause significant changes in TES, DHEA-S, or PRL levels. Testosterone concentrations were higher in men characterized by higher levels of PA, both before and after the sauna bath.


Assuntos
Imersão , Banho a Vapor , Temperatura Baixa , Humanos , Hidrocortisona , Masculino , Água , Adulto Jovem
20.
Artigo em Inglês | MEDLINE | ID: mdl-33922289

RESUMO

The health benefits of sauna baths are attracting ever-increasing interest. Therefore, the purpose of this study was to evaluate the effects of 12 high-temperature (100 °C) sauna baths on body composition of 23 healthy young men, divided into a control group (CG) and a sauna group (SG). Both groups were initially evaluated by dual-energy X-ray absorptiometry (DXA), after which the SG experienced 12 sessions of sauna baths at high temperatures (100 °C). Initial measurements were carried out after the sauna sessions and after two weeks of decay in both groups. The muscle mass of the right leg (pre vs. decay: 9.50 (5.59) vs. 10.52 (5.15); p < 0.05; Δ 1.07%), bone mineral density (pre vs. post: 1.221 (0.35) vs. 1.315 (0.45); p < 0.05; Δ 7.7%) and bone mineral content (pre vs. post: 0.470 (0.21) vs. 0.499 (0.22); p < 0.05; Δ 6.17%) of the left leg increased in the SG after the sauna baths. It seems that exposure to heat at high temperatures could produce improvements in bone and muscle mass.


Assuntos
Banho a Vapor , Banhos , Pressão Sanguínea , Composição Corporal , Temperatura Corporal , Frequência Cardíaca , Temperatura Alta , Humanos , Masculino , Temperatura
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