Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 3.488
Filtrar
1.
BMC Psychiatry ; 23(1): 38, 2023 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-36639626

RESUMO

BACKGROUND: Most studies agree that the Covid-19 pandemic and the subsequent lockdown had a negative impact on mental health. On the other hand, international studies have shown that psychiatric emergency departments (pED) experienced a decrease in presentations and admissions. METHODS: Retrospective chart review of all pED presentations and admissions during the first wave of Covid-19 pandemic in Germany (Covid-19 period: 3/2/20 to 05/24/20) in a psychiatric hospital in Berlin compared to 1 year earlier (pre-Covid-19 period). Descriptive statistics and logistic regression were performed. RESULTS: We observed no statistical significant changes in overall pED presentations and overall hospital admissions during the Covid-19 period compared to the pre-Covid-19 period (813 vs. 894, - 9.1%, p = 0.064 and (363 vs. 437, - 16.9%, p = 0.080 respectively). In the subgroup analysis, less patients with depressive disorders (p = 0.035) and with personality disorders (p = 0.002) presented to the pED, a larger number of presentations with schizophrenia was observed (p = 0.020). In the Covid-19 period, less patients with substance use disorder and paranoid schizophrenia were admitted to the hospital via the pED than in the pre-Covid-19 period (p = 0.035 and p = 0.006, respectively). Bed capacity was reduced in the Covid-19 period by - 32.8% (p <  0.001). Presentations in police custody were 13.7% (p = 0.029) higher during the Covid-19 compared to pre-Covid-19 period, with higher rates in female presentations (p = 0.008) and suicide attempts (p = 0.012) and less hospital admissions (p = 0.048). Logistic regression analyses revealed that positive predictors for pED presentation during Covid-19 period were police custody (p <  0.001), being redirected from another hospital (p <  0.001), suicide attempt (p = 0.038), suicidal thoughts (p = 0.004), presentation with paranoid schizophrenia (p = 0.001) and bipolar and manic disorders (p = 0.004), negative predictors were hospital admission (p <  0.001), depressive disorders (p = 0.021) and personality disorders (p <  0.001). CONCLUSIONS: A larger number of presentations in police custody during the Covid-19 period may represent untreated medical needs. This was seen predominantly in female patients, suggesting this subgroup might have suffered particularly under lockdown measures. Patients with paranoid schizophrenia were the only subgroup, which increased in absolute numbers, also suggesting a particular lockdown effect. Reduced bed capacity due to infection curbing measures is suggestive to have played an important role in augmenting the threshold for hospital admissions.


Assuntos
Transtorno Bipolar , COVID-19 , Humanos , Feminino , Estudos Retrospectivos , Berlim/epidemiologia , Pandemias , COVID-19/epidemiologia , Controle de Doenças Transmissíveis , Alemanha/epidemiologia , Serviço Hospitalar de Emergência
2.
BMC Psychiatry ; 23(1): 31, 2023 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-36635663

RESUMO

BACKGROUND: Large-scale collaborative efforts in the field of psychiatric genetics have made substantial progress in unraveling the biological architecture of schizophrenia (SCZ). Although both genetic and environmental factors are known to play a role in schizophrenia etiology our mechanistic understanding of how they shape risk, resilience and disease trajectories remains limited. METHODS: Here, we present the study protocol of the Berlin Research Initiative for Diagnostics, Genetic and Environmental Factors of Schizophrenia (BRIDGE-S), which aims to collect a densely phenotyped genetic cohort of 1,000 schizophrenia cases and 1,000 controls. The study's main objectives are to build a resource for i) promoting genetic discoveries and ii) genotype-phenotype associations to infer specific disease subtypes, and iii) exploring gene-environment interactions using polyrisk models. All subjects provide a biological sample for genotyping and complete a core questionnaire capturing a variety of environmental exposures, demographic, psychological and health data. Approximately 50% of individuals in the sample will further undergo a comprehensive clinical and neurocognitive assessment. DISCUSSION: With BRIDGE-S we created a valuable database to study genomic and environmental contributions to schizophrenia risk, onset, and outcomes. Results of the BRIDGE-S study could yield insights into the etiological mechanisms of schizophrenia that could ultimately inform risk prediction, and early intervention and treatment strategies.


Assuntos
Esquizofrenia , Humanos , Esquizofrenia/etiologia , Esquizofrenia/genética , Predisposição Genética para Doença , Berlim , Interação Gene-Ambiente , Fenótipo , Estudo de Associação Genômica Ampla
3.
J Neuroeng Rehabil ; 20(1): 17, 2023 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-36707885

RESUMO

BACKGROUND: Assistive hand exoskeletons are promising tools to restore hand function after cervical spinal cord injury (SCI) but assessing their specific impact on bimanual hand and arm function is limited due to lack of reliable and valid clinical tests. Here, we introduce the Berlin Bimanual Test for Tetraplegia (BeBiTT) and demonstrate its psychometric properties and sensitivity to assistive hand exoskeleton-related improvements in bimanual task performance. METHODS: Fourteen study participants with subacute cervical SCI performed the BeBiTT unassisted (baseline). Thereafter, participants repeated the BeBiTT while wearing a brain/neural hand exoskeleton (B/NHE) (intervention). Online control of the B/NHE was established via a hybrid sensorimotor rhythm-based brain-computer interface (BCI) translating electroencephalographic (EEG) and electrooculographic (EOG) signals into open/close commands. For reliability assessment, BeBiTT scores were obtained by four independent observers. Besides internal consistency analysis, construct validity was assessed by correlating baseline BeBiTT scores with the Spinal Cord Independence Measure III (SCIM III) and Quadriplegia Index of Function (QIF). Sensitivity to differences in bimanual task performance was assessed with a bootstrapped paired t-test. RESULTS: The BeBiTT showed excellent interrater reliability (intraclass correlation coefficients > 0.9) and internal consistency (α = 0.91). Validity of the BeBiTT was evidenced by strong correlations between BeBiTT scores and SCIM III as well as QIF. Wearing a B/NHE (intervention) improved the BeBiTT score significantly (p < 0.05) with high effect size (d = 1.063), documenting high sensitivity to intervention-related differences in bimanual task performance. CONCLUSION: The BeBiTT is a reliable and valid test for evaluating bimanual task performance in persons with tetraplegia, suitable to assess the impact of assistive hand exoskeletons on bimanual function.


Assuntos
Exoesqueleto Energizado , Traumatismos da Medula Espinal , Humanos , Psicometria , Reprodutibilidade dos Testes , Berlim , Mãos , Quadriplegia/diagnóstico , Quadriplegia/reabilitação , Traumatismos da Medula Espinal/reabilitação
5.
Dtsch Med Wochenschr ; 147(24-25): 1590-1595, 2022 Dec.
Artigo em Alemão | MEDLINE | ID: mdl-36470267

RESUMO

There is frequent confusion between Theodor Langhans (1839-1915) and Paul Langerhans (1847-1888) in the literature. Theodor Langhans was a German pathologist who discovered and described the "giant cells" with nuclei close to the outer membrane of the tubercles. Today, these cells are called "Langhans' giant cells". The eponym "Langerhans' cells" refers to dendritic cells in the stratum spinosum of the epidermis. Paul Langerhans described these cells for a competition organised by the Berlin Medical Faculty when he was still a student. Most doctors know Paul Langerhans through the first description of the "Langerhans' islet cells" of the pancreas. Langerhans died of tuberculosis at the age of 40 after a long exile on the island of Madeira.


Assuntos
Epônimos , Células de Langerhans , Masculino , Humanos , Epiderme , Berlim , Pâncreas
7.
BMC Neurol ; 22(1): 479, 2022 Dec 14.
Artigo em Inglês | MEDLINE | ID: mdl-36517734

RESUMO

BACKGROUND: Large-scale disease overarching longitudinal data are rare in the field of neuroimmunology. However, such data could aid early disease stratification, understanding disease etiology and ultimately improve treatment decisions. The Berlin Registry of Neuroimmunological Entities (BERLimmun) is a longitudinal prospective observational study, which aims to identify diagnostic, disease activity and prognostic markers and to elucidate the underlying pathobiology of neuroimmunological diseases. METHODS: BERLimmun is a single-center prospective observational study of planned 650 patients with neuroimmunological disease entity (e.g. but not confined to: multiple sclerosis, isolated syndromes, neuromyelitis optica spectrum disorders) and 85 healthy participants with 15 years of follow-up. The protocol comprises annual in-person visits with multimodal standardized assessments of medical history, rater-based disability staging, patient-report of lifestyle, diet, general health and disease specific symptoms, tests of motor, cognitive and visual functions, structural imaging of the neuroaxis and retina and extensive sampling of biological specimen. DISCUSSION: The BERLimmun database allows to investigate multiple key aspects of neuroimmunological diseases, such as immunological differences between diagnoses or compared to healthy participants, interrelations between findings of functional impairment and structural change, trajectories of change for different biomarkers over time and, importantly, to study determinants of the long-term disease course. BERLimmun opens an opportunity to a better understanding and distinction of neuroimmunological diseases.


Assuntos
Esclerose Múltipla , Neuromielite Óptica , Humanos , Aquaporina 4 , Autoanticorpos , Berlim , Estudos Longitudinais , Esclerose Múltipla/diagnóstico , Glicoproteína Mielina-Oligodendrócito , Neuromielite Óptica/diagnóstico , Estudos Observacionais como Assunto , Sistema de Registros
8.
Arch Virol ; 168(1): 9, 2022 Dec 25.
Artigo em Inglês | MEDLINE | ID: mdl-36566475

RESUMO

The order Hepelivirales comprises RNA viruses of four families (Alphatetraviridae, Benyviridae, Hepeviridae, and Matonaviridae). Sequencing of virus genomes from water samples from the Havel River and the Teltow Canal (Teltowkanal) in Berlin, Germany, revealed 25 almost complete and 68 partial genomes of viruses presumably belonging to the order Hepelivirales. Only one of these viruses exhibited a relationship to a known member of this order. The members of one virus clade have a polymerase with a permuted order of the conserved palm subdomain motifs resembling the polymerases of permutotetraviruses and birnaviruses. Overall, our study further demonstrates the diversity of hepeliviruses and indicates the enzootic prevalence of hepeliviruses in unknown hosts.


Assuntos
Vírus de RNA , Humanos , Berlim , Vírus de RNA/genética , Alemanha , Rios
9.
Science ; 378(6619): 466-469, 2022 11 04.
Artigo em Inglês | MEDLINE | ID: mdl-36378985

RESUMO

In Berlin, pioneering research into urban ecology has found surprising biodiversity in the city's green spaces.


Assuntos
Biodiversidade , Cidades , Animais , Urbanização , Berlim
10.
PLoS One ; 17(11): e0277699, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36395156

RESUMO

BACKGROUND: Superspreading events are important drivers of the SARS-CoV-2 pandemic and long-range (LR) transmission is believed to play a major role. We investigated two choir outbreaks with different attack rates (AR) to analyze the contribution of LR transmission and highlight important measures for prevention. METHODS: We conducted two retrospective cohort studies and obtained demographic, clinical, laboratory and contact data, performed SARS-CoV-2 serology, whole genome sequencing (WGS), calculated LR transmission probabilities, measured particle emissions of selected choir members, and calculated particle air concentrations and inhalation doses. RESULTS: We included 65 (84%) and 42 (100%) members of choirs 1 and 2, respectively, of whom 58 (89%) and 10 (24%) became cases. WGS confirmed strain identity in both choirs. Both primary cases transmitted presymptomatically. Particle emission rate when singing was 7 times higher compared to talking. In choir 1, the median concentration of primary cases' emitted particles in the room was estimated to be 8 times higher, exposure at least 30 minutes longer and room volume smaller than in choir 2, resulting in markedly different estimated probabilities for LR transmission (mode: 90% vs. 16%, 95% CI: 80-95% vs. 6-36%). According to a risk model, the first transmission in choir 1 occurred likely after 8 minutes of singing. CONCLUSIONS: The attack rate of the two choirs differed significantly reflecting the differences in LR transmission risks. The pooled proportion of cases due to LR transmission was substantial (81%; 55/68 cases) and was facilitated by likely highly infectious primary cases, high particle emission rates, and indoor rehearsing for an extended time. Even in large rooms, singing of an infectious person may lead to secondary infections through LR exposure within minutes. In the context of indoor gatherings without mask-wearing and waning or insufficient immunity, these results highlight the ongoing importance of non-pharmaceutical interventions wherever aerosols can accumulate.


Assuntos
COVID-19 , SARS-CoV-2 , Humanos , SARS-CoV-2/genética , Berlim , Estudos Retrospectivos , COVID-19/epidemiologia , Surtos de Doenças , Alemanha/epidemiologia
11.
Euro Surveill ; 27(45)2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36367010

RESUMO

Before the international spread of monkeypox in May 2022, PCR kits for the detection of orthopoxviruses, and specifically monkeypox virus, were rarely available. Here we describe the evaluation of 11 recently developed commercially available PCR kits for the detection of monkeypox virus DNA. All tested kits are currently intended for research use only and clinical performance still needs to be assessed in more detail, but all were suitable for diagnostics of monkeypox virus, with variations in specificity rather than sensitivity.


Assuntos
Varíola dos Macacos , Humanos , Varíola dos Macacos/diagnóstico , Varíola dos Macacos/epidemiologia , Vírus da Varíola dos Macacos/genética , Berlim , DNA Viral/genética , DNA Viral/análise , Reação em Cadeia da Polimerase
12.
BMJ Open ; 12(11): e061453, 2022 11 02.
Artigo em Inglês | MEDLINE | ID: mdl-36323482

RESUMO

INTRODUCTION: Excessive internet use can lead to problems for some individuals. The WHO has introduced Gaming Disorder in the International Classification of Diseases-11 (ICD-11). Previous research has shown that other internet applications can cause serious mental health problems as well. It is important to provide measures of prevention, early intervention and therapy for internet use disorders (IUDs). METHODS AND ANALYSIS: The study 'Stepped Care Approach for Problematic Internet use Treatment' is a randomised, two-arm, parallel-group, observer-blind trial. The aim of the study is to investigate if a stepped care approach is effective to reduce symptom severity for IUD. The sample is primarily recruited online with a focus on employees in companies with support of health insurances. After screening, the stepped care approach depends on the success of the previous step-that is, the successful reduction of criteria-and comprise: (1) app-intervention with questionnaires and feedback, (2) two telephone counsellings (duration: 50 min) based on motivational interviewing, (3) online therapy over 17 weeks (15 weekly group sessions, eight individual sessions) based on cognitive-behavioural therapy. A follow-up is conducted after 6 months. A total of 860 participants will be randomised. Hierarchical testing procedure is used to test the coprimary endpoints number of Diagnostic and Statistical Manual of Mental Disorders, fifth edition and ICD-11 criteria. Primary analysis will be performed with a sequential logit model. ETHICS AND DISSEMINATION: The study has been approved by the Ethics Committees of the Universities of Lübeck (file number: 21-068), Mainz (file number: 2021-15907) and Berlin (file number: 015.2021). Results will be reported in accordance to the CONSORT statement. If the approach is superior to the control condition, it may serve as part of treatment for IUD. TRIAL REGISTRATION NUMBER: DRKS00025994.


Assuntos
Terapia Cognitivo-Comportamental , Entrevista Motivacional , Telemedicina , Humanos , Uso da Internet , Berlim , Internet , Resultado do Tratamento , Ensaios Clínicos Controlados Aleatórios como Assunto
13.
Nervenarzt ; 93(Suppl 1): 32-41, 2022 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-36197475

RESUMO

This paper commemorates the careers and the scientific influence of the clinical neurologists Kurt Goldstein and Friedrich Heinrich Lewy including their forced migration in the mid-1930s. Goldstein (1878-1965) set up independent neurological departments in Frankfurt/Main and Berlin, adopting a decidedly holistic approach in medical care, research and teaching. He is therefore considered a co-founder of modern neuropsychology and neurorehabilitation. Goldstein came into the focus of the National Socialists as a Jew, socialist and adherent of psychotherapeutic methods. After a short incarceration he fled via Switzerland and Holland to the USA. Lewy (1885-1970) for his part specialized in neuropathological examinations and in 1912 quickly discovered the inclusion bodies in the cytoplasm of nerve cells named after him. As head of a neurological institute in Berlin with inpatient beds, he decided to leave Germany as early as 1933 and arrived after a stopover in England in the United States one year later. The biographies of the two highly innovative neurologists illustrate that career opportunities for doctors of Jewish descent were already clearly limited during the Weimar Republic and that they had to face anti-Semitic tendencies even after their arrival in the USA.


Assuntos
Neurologistas , Médicos , Berlim , Alemanha , História do Século XX , Humanos , Socialismo Nacional , Estados Unidos
14.
Nervenarzt ; 93(Suppl 1): 62-79, 2022 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-36197478

RESUMO

Before 1933 Berlin was considered a center of clinical neurology and neuroscientific research in the German Reich. Using a group biographical approach and drawing upon scattered secondary literature as well as upon various archival documents, this article provides an overview of 12 less well-known physicians and researchers who were forced into exile during the nationalsocialist (NS) era, primarily for racist reasons. Among those affected by NS persecution were Franz Kramer and Fredy Quadfasel (Charité), Ernst Haase, Carl Felix List, and Lipman Halpern (Moabit Hospital), Paul Schuster (Hufeland Hospital), and Clemens Ernst Benda (Augusta Hospital). Others who were forced to emigrate were Franz Josef Kallmann (Herzberge Sanatorium), Max Bielschowsky, and Hans Löwenbach (Kaiser Wilhelm Institute for Brain Research), Otto Maas (Berlin-Buch Clinic), and Kurt Löwenstein (Lankwitz). A total of 6 neurological departments at municipal hospitals were run by (in NS terminology) "non-Aryans" in 1933. With their expulsion, the existence of neurological treatment and training centers outside the university ended and did not resume until the 1960s.


Assuntos
Neurologia , Médicos , Academias e Institutos , Berlim , Alemanha , História do Século XX , Humanos , Socialismo Nacional
15.
NTM ; 30(4): 599-632, 2022 12.
Artigo em Alemão | MEDLINE | ID: mdl-36301328

RESUMO

Launched in 1982, the so-called Berliner Wissenschaftsladen e. V. (WILAB) belonged to the scattered West-German ventures in "counter-science". This article situates the origins of the "Laden" (~ workshop)-an "alternative" spin-off of sorts, spawned from the Technical University of Berlin-in the context of contemporary advances in regional science policy. In this connection, the ailing, de-industrializing "island city" arguably even played a certain pioneering role: elements of its multipronged "innovation offensive", which peaked in the early-to-mid 1980s, were visible beyond city limits, including the trade show BIG TECH and, notably, the Berlin Center for Innovation and New Enterprises (BIG), the FRG's first start-up "incubator", which opened in 1983.In other words, politically-minded scientists in tendency now had to deal with conditions that were less and less conducive to dreams of a "socially engaged" and "non-alienated" (counter-)science. Indeed, while hardly opposed to the new gospel of innovation, it's not surprising that ventures such as WILAB, committed as they were to the production of "socially useful" science, found themselves increasingly marginalized. It's as such a marginal venture, my argument goes, that WILAB's prima facie hopeless attempt to initiate a different, more "humane" information technology sheds an instructive light on the emergence of "entrepreneurial" science in the FRG during the 1970s and 1980s.


Assuntos
Médicos , Humanos , Berlim , Cidades
17.
Eur J Dermatol ; 31(4): 521-529, 2022 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-36094385

RESUMO

Background: The COVID-19 pandemic imposes major challenges for care of cancer patients. Objectives: Our aim was to assess the effects of the pandemic on treatment and appointments of patients with malignant melanoma based on a large skin cancer centre in Berlin, Germany, and identify reasons for, and impact factors associated with these changes. Materials & Methods: Patients with melanoma treated from January 1st 2019 received a postal survey with questions on impairment due to the pandemic, fear of COVID-19, fear of melanoma, changes in therapy and/or appointments, including reasons for the changes. Impact factors on postponed/missed appointments were examined using descriptive analyses and multivariate logistic regression. Results: The response rate was 41.3% (n = 324; 57.4% males; mean age: 67.9 years). Among 104 participants currently receiving therapy, four (3.8%) reported treatment changes due to the pandemic. Postponements or cancellations of appointments occurred in 48 participants (14.8%), most frequently, at their own request (81.3%) due to fear of SARS-CoV-2 infection (68.8%). Current treatment was associated with a reduced chance of post-poning/missing appointments (OR = 0.208, p = 0.003), whereas a high or very high level of concern for COVID-19 (OR = 6.806, p = 0.034; OR= 10.097, p = 0.038), SARS-CoV-2 infection among close acquaintances (OR = 4.251, p = 0.026), anxiety disorder (OR = 5.465, p = 0.016) and AJCC stage IV (OR = 3.108, p = 0.048) were associated with a higher likelihood of postponing/missing appointments. Conclusion: Among our participants, treatment changes were rare and the proportion of missed/delayed appointments was rather small. The main reasons for delays/cancellations of appointments were anxiety and concern for COVID-19.


Assuntos
COVID-19 , Melanoma , Idoso , Berlim , Feminino , Alemanha/epidemiologia , Humanos , Masculino , Melanoma/epidemiologia , Melanoma/terapia , Pandemias , SARS-CoV-2
19.
Eur J Immunol ; 52(9): 1383, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-36050912
20.
Artigo em Inglês | MEDLINE | ID: mdl-36011738

RESUMO

The COVID-19 pandemic and related restrictions have affected the wellbeing of schoolchildren worldwide, but the extent and duration of specific problems are still not completely understood. We aimed to describe students' psychosocial and behavioral parameters and associated factors during the COVID-19 pandemic in Berlin, Germany. Our longitudinal study included 384 students from 24 randomly selected Berlin primary and secondary schools, assessing psychosocial wellbeing at four time points between June 2020 and March 2021. We analyzed temporal changes in the proportions of anxiety, fear of infection, reduced health-related quality of life (HRQoL), physical activity and social contacts, as well as sociodemographic and economic factors associated with anxiety, fear of infection and HRQoL. During the observation period, the presence of anxiety symptoms increased from 26.2% (96/367) to 34.6% (62/179), and fear of infection from 28.6% (108/377) to 40.6% (73/180). The proportion of children with limited social contacts (<1/week) increased from 16.4% (61/373) to 23.5% (42/179). Low physical activity (<3 times sports/week) was consistent over time. Low HRQoL was observed among 44% (77/174) of children. Factors associated with anxiety were female sex, increasing age, secondary school attendance, lower household income, and the presence of adults with anxiety symptoms in the student´s household. Fear of infection and low HRQoL were associated with anxiety. A substantial proportion of schoolchildren experienced unfavorable psychosocial conditions during the COVID-19 pandemic in 2020/2021. Students from households with limited social and financial resilience require special attention.


Assuntos
COVID-19 , Adulto , Ansiedade/epidemiologia , Ansiedade/psicologia , Berlim/epidemiologia , COVID-19/epidemiologia , Criança , Depressão/psicologia , Feminino , Alemanha/epidemiologia , Humanos , Estudos Longitudinais , Masculino , Pandemias , Qualidade de Vida , SARS-CoV-2
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...