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1.
Development ; 151(13)2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38984540

RESUMO

Germ granules have been hypothesized to deliver mRNAs of germ cell fate determinants to primordial germ cells. Now, a new study in Development finds that many mRNAs enriched in germ granules are not involved in germline development in Caenorhabditis elegans. To find out more about the story behind the paper, we caught up with first author Alyshia Scholl, second author Yihong Liu and corresponding author Geraldine Seydoux, Professor at Johns Hopkins University School of Medicine.


Assuntos
Caenorhabditis elegans , Animais , Caenorhabditis elegans/genética , Células Germinativas/metabolismo , Biologia do Desenvolvimento/história , História do Século XXI , História do Século XX , Humanos , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Proteínas de Caenorhabditis elegans/metabolismo , Proteínas de Caenorhabditis elegans/genética
3.
Development ; 151(13)2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38954602

RESUMO

Sonia Sen is Group Leader at the Tata Institute for Genetics and Society in Bangalore, India. Her group is interested in understanding neurodevelopment and behaviour in Drosophila and Anopheles. We spoke to Sonia over a video call to talk about her research career, her transition to becoming a group leader, and the work that the Indian Society of Developmental Biologists is doing.


Assuntos
Biologia do Desenvolvimento , Animais , História do Século XXI , Índia , Humanos , História do Século XX
4.
Development ; 151(14)2024 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-38995119

RESUMO

Peter Rugg-Gunn is a Group Leader and Head of Public Engagement at the Babraham Institute in Cambridge, UK, interested in the epigenome during early human development. Peter is scientific lead of the Human Developmental Biology Initiative (HDBI), a member of the Scientific and Clinical Advances Advisory Committee of the Human Fertilisation and Embryology Authority (HFEA), and is active in UK and international efforts to establish guidance in stem cell-based embryo models. We spoke to Peter about his career path, his interest in public dialogue and his role as an Editor for Development.


Assuntos
Biologia do Desenvolvimento , Humanos , História do Século XXI , Biologia do Desenvolvimento/história , História do Século XX , Reino Unido , Embriologia/história
5.
Development ; 151(13)2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38958074

RESUMO

The bromodomain and extra-terminal (BET) family of proteins reads epigenetic histone acetylation marks on the genome and regulates the transcriptional machinery. In their study, Carole LaBonne and colleagues reveal the role of BET protein activity in the maintenance of pluripotency and establishment of the neural crest in Xenopus laevis. To know more about their work, we spoke to the first author Paul Huber and the corresponding author Carole LaBonne, Developmental and Stem Cell Biologist at Northwestern University.


Assuntos
Xenopus laevis , Animais , História do Século XXI , Humanos , História do Século XX , Crista Neural/metabolismo , Biologia do Desenvolvimento/história
6.
Development ; 151(13)2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38975829

RESUMO

Male pheromones accelerate the development of hermaphrodite larvae in Caenorhabditis elegans, but the importance of this phenomenon is not well understood. A new paper in Development shows that pheromone exposure during larval stage 3 helps coordinate behaviour and development by modulating the timing of the transition to larval stage 4. To learn more about the story behind the paper, we caught up with first author Denis Faerberg who carried out the work in the lab of the corresponding author Ilya Ruvinsky at Northwestern University, USA.


Assuntos
Caenorhabditis elegans , Animais , Feromônios/metabolismo , Humanos , Larva/crescimento & desenvolvimento , Biologia do Desenvolvimento/história , História do Século XXI , Masculino , História do Século XX
7.
Dev Biol ; 513: 31-32, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38844024
8.
Development ; 151(11)2024 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-38856047

RESUMO

The shoot apical meristem is a key stem cell niche in plants, and proper stem cell maintenance is partly regulated by CLAVATA3 (CLV3). Without CLV3 meristems overgrow, but the mechanistic basis of this phenotype was unclear. A new paper in Development suggests that CLV3 modulates the physical properties of meristematic stem cells, and that these properties help shape meristem morphology. To learn more about the story behind the paper, we caught up with first author Léa Rambaud-Lavigne and corresponding authors Namrata Gundiah, Arezki Boudaoud and Pradeep Das.


Assuntos
Meristema , Meristema/crescimento & desenvolvimento , Meristema/citologia , Proteínas de Arabidopsis/metabolismo , Proteínas de Arabidopsis/genética , Arabidopsis/crescimento & desenvolvimento , História do Século XXI , Biologia do Desenvolvimento/história , História do Século XX
9.
Cell ; 187(13): 3163-3164, 2024 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-38906092

RESUMO

Awe-inspiring developmental biology is all around us. In this 50th Anniversary focus issue, we celebrate developmental biology with content paying homage to the incredible progress the field has witnessed over the last five decades as well as inspirational content looking forward toward what might lie ahead.


Assuntos
Biologia do Desenvolvimento , Animais , Humanos
10.
Cell ; 187(13): 3224-3228, 2024 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-38906097

RESUMO

The next 50 years of developmental biology will illuminate exciting new discoveries but are also poised to provide solutions to important problems society faces. Ten scientists whose work intersects with developmental biology in various capacities tell us about their vision for the future.


Assuntos
Biologia do Desenvolvimento , Biologia do Desenvolvimento/tendências , Humanos , Células-Tronco/citologia , Animais , Pesquisa com Células-Tronco
12.
Development ; 151(12)2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38912552

RESUMO

The field of developmental metabolism is experiencing a technological revolution that is opening entirely new fields of inquiry. Advances in metabolomics, small-molecule sensors, single-cell RNA sequencing and computational modeling present new opportunities for exploring cell-specific and tissue-specific metabolic networks, interorgan metabolic communication, and gene-by-metabolite interactions in time and space. Together, these advances not only present a means by which developmental biologists can tackle questions that have challenged the field for centuries, but also present young scientists with opportunities to define new areas of inquiry. These emerging frontiers of developmental metabolism were at the center of a highly interactive 2023 EMBO workshop 'Developmental metabolism: flows of energy, matter, and information'. Here, we summarize key discussions from this forum, emphasizing modern developmental biology's challenges and opportunities.


Assuntos
Biologia do Desenvolvimento , Biologia do Desenvolvimento/tendências , Humanos , Animais , Metabolômica , Redes e Vias Metabólicas
13.
Development ; 151(12)2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38934415

RESUMO

Skin renewal is characterised by progenitor cells at the epidermal basal layer dividing and differentiating, yet the identity and properties of these progenitors remain poorly understood. In a new study, Tudorita Tumbar and colleagues identify, for the first time in vivo in the mouse epidermis, a distinct population of non-self-renewing progenitor cells that exhibit biphasic transit-amplifying behaviour. To find out more about the story behind the paper, we caught up with first author Sangeeta Ghuwalewala, penultimate author David Shalloway and corresponding author Tudorita (Doina) Tumbar, Professor of Molecular Biology and Genetics at Cornell University, USA.


Assuntos
Células-Tronco , Animais , Camundongos , Células-Tronco/citologia , Células-Tronco/metabolismo , História do Século XXI , História do Século XX , Humanos , Biologia do Desenvolvimento/história
14.
Development ; 151(13)2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38934481

RESUMO

Jean-Paul (JP) Vincent is Group Leader at the Francis Crick Institute, London. His lab is interested in understanding how cells communicate to form organs during development. In 2024, he was awarded the British Society for Developmental Biology (BSDB) Waddington medal, which honours outstanding research performance and services to the developmental biology community. This interview was conducted at the 2024 BSDB and Genetics Society Joint Spring Meeting in Warwick, UK, where JP was presented with the medal.


Assuntos
Distinções e Prêmios , Biologia do Desenvolvimento , Biologia do Desenvolvimento/história , História do Século XXI , Humanos , História do Século XX , Londres , Animais , Reino Unido
15.
Development ; 151(11)2024 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-38832825

RESUMO

Germ stem cells in Drosophila reside within a specialized stem cell niche, but the effects of stress on these stem cell populations have been elusive. In a new study, Roach and Lenhart show that repeated mating stress induces reversible changes in the germ stem cell niche. To know more about their work, we spoke to first author, Tiffany Roach, and corresponding author, Kari Lenhart, Principal Investigator at Drexel University in Philadelphia, USA.


Assuntos
Células Germinativas , Animais , História do Século XXI , Células Germinativas/citologia , História do Século XX , Nicho de Células-Tronco/fisiologia , Drosophila , Humanos , Biologia do Desenvolvimento/história , Células-Tronco/citologia
16.
Development ; 151(12)2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38885078

RESUMO

The steroid hormone ecdysone (Ec) is secreted from the prothoracic gland for growth in the developing Drosophila larva. How Ec-dependent regeneration can occur despite a drop in circulating Ec in the injured developing larvae remains unclear. In a new study in Development, Kenneth Moberg and colleagues find that injury induces local Ec synthesis at the wounded site to delay development and promote tissue repair in Drosophila. To learn more about the story behind the paper, we caught up with first author Douglas Terry and corresponding author Kenneth Moberg, Professor of Cell Biology at Emory University School of Medicine, USA.


Assuntos
Ecdisona , Animais , Ecdisona/metabolismo , Drosophila , História do Século XXI , História do Século XX , Biologia do Desenvolvimento/história , Humanos , Larva/crescimento & desenvolvimento , Drosophila melanogaster
17.
Development ; 151(12)2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38885080

RESUMO

Ariel Waisman is a CONICET Junior Researcher in the Laboratory of Applied Research in Neurosciences at FLENI in Buenos Aires, Argentina. Ariel's group studies gene regulatory networks in human pluripotent stem cells to address mechanisms of development and cardiac differentiation, among other topics. We spoke to Ariel over Teams to learn more about his career path, the research interests in his group, and the challenges faced by researchers in Argentina and the Global South.


Assuntos
Biologia do Desenvolvimento , Humanos , História do Século XXI , História do Século XX , Argentina , Células-Tronco Pluripotentes/citologia , Células-Tronco Pluripotentes/metabolismo , Diferenciação Celular , Redes Reguladoras de Genes , Neurociências
18.
Development ; 151(9)2024 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-38722098

RESUMO

During development, the gastrointestinal tract undergoes patterning along its anterior-posterior axis to define regions with distinct organs and functions. A new paper in Development derives human intestinal organoids from an individual with duodenal defects and a compound heterozygous variant in the gene encoding the transcription factor RFX6. By studying these organoids, the authors identify novel roles for RFX6 in intestinal patterning. To learn more about the story behind the paper, we caught up with first author J. Guillermo Sanchez and corresponding author Jim Wells, an endowed professor in the Division of Developmental Biology at Cincinnati Children's Hospital, USA, where he is also the Director for Basic Research in the Division of Endocrinology.


Assuntos
Biologia do Desenvolvimento , Humanos , História do Século XXI , História do Século XX , Biologia do Desenvolvimento/história , Fatores de Transcrição de Fator Regulador X/genética , Fatores de Transcrição de Fator Regulador X/metabolismo , Organoides/metabolismo , Padronização Corporal/genética
19.
Development ; 151(9)2024 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-38722099

RESUMO

Planarians grow when they are fed and shrink during periods of starvation. However, it is unclear how they maintain appropriate body proportions as their size changes. A new paper in Development investigates the differences between growth and shrinkage dynamics and builds a mathematical model to explore the mechanisms underpinning these two processes. To learn more about the story behind the paper, we caught up with first author, Jason Ko, and corresponding author, Daniel Lobo, Associate Professor at the University of Maryland.


Assuntos
Planárias , Animais , Humanos , Biologia do Desenvolvimento/história , História do Século XXI
20.
Development ; 151(9)2024 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-38722097

RESUMO

Bez is a Class B scavenger receptor in Drosophila that is yet to be characterised. In a new study, Margret Bülow and colleagues uncover a role for Bez in mobilising lipids from Drosophila adipocytes into the ovary for oocyte maturation. To find out more about the people behind the paper, we caught up with first author, Pilar Carrera, and corresponding author, Margret Bülow, Group Leader at the University of Bonn.


Assuntos
Proteínas de Drosophila , Animais , Proteínas de Drosophila/metabolismo , Proteínas de Drosophila/genética , Feminino , Drosophila , História do Século XXI , Humanos , Adipócitos/citologia , Adipócitos/metabolismo , História do Século XX , Biologia do Desenvolvimento/história , Oócitos/metabolismo , Oócitos/citologia , Drosophila melanogaster , Ovário/metabolismo , Ovário/citologia
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