Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 11.451
Filtrar
1.
IEEE Pulse ; 12(5): 27-29, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34784268

RESUMO

One of the core missions of the IEEE Engineering in Medicine and Biology Society (EMBS) is to be a platform for enhancing the personal and professional development of its members. This month we focus on two related priority areas of the IEEE EMBS Student Activities Committee (SAC) [1], namely Leadership Development and Professional Development Portfolios, and bring you up close to the student and professional leaders actively building these programs. The Leadership Development Portfolio, currently led by Agnieszka Lach from Silesian University of Technology, Gliwice, Poland, focuses on nurturing and supporting student leaders of the EMBS globally. The Professional Development Portfolio, currently led by Josée Rosset from the University of Manitoba, Winnipeg, MB, Canada, aims to help EMBS student members develop their skills and experiences in the practice of biomedical engineering.


Assuntos
Medicina , Estudantes de Medicina , Bioengenharia , Engenharia Biomédica , Engenharia , Humanos , Liderança
2.
Nat Commun ; 12(1): 5997, 2021 10 14.
Artigo em Inglês | MEDLINE | ID: mdl-34650046

RESUMO

Determining the time since death, i.e., post-mortem interval (PMI), often plays a key role in forensic investigations. The current standard PMI-estimation method empirically correlates rectal temperatures and PMIs, frequently necessitating subjective correction factors. To overcome this, we previously developed a thermodynamic finite-difference (TFD) algorithm, providing a rigorous method to simulate post-mortem temperatures of bodies assuming a straight posture. However, in forensic practice, bodies are often found in non-straight postures, potentially limiting applicability of this algorithm in these cases. Here, we develop an individualised approach, enabling PMI reconstruction for bodies in arbitrary postures, by combining photogrammetry and TFD modelling. Utilising thermal photogrammetry, this approach also represents the first non-contact method for PMI reconstruction. The performed lab and crime scene validations reveal PMI reconstruction accuracies of 0.26 h ± 1.38 h for true PMIs between 2 h and 35 h and total procedural durations of ~15 min. Together, these findings broaden the potential applicability of TFD-based PMI reconstruction.


Assuntos
Autopsia/métodos , Corpo Humano , Imageamento Tridimensional/métodos , Idoso , Idoso de 80 Anos ou mais , Algoritmos , Engenharia Biomédica , Testes Diagnósticos de Rotina , Feminino , Humanos , Masculino , Mudanças Depois da Morte
3.
Chem Soc Rev ; 50(20): 11381-11485, 2021 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-34661206

RESUMO

To date, nanotechnology has increasingly been identified as a promising and efficient means to address a number of challenges associated with public health. In the past decade, two-dimensional (2D) biomaterials, as a unique nanoplatform with planar topology, have attracted explosive interest in various fields such as biomedicine due to their unique morphology, physicochemical properties and biological effect. Motivated by the progress of graphene in biomedicine, dozens of types of ultrathin 2D biomaterials have found versatile bio-applications, including biosensing, biomedical imaging, delivery of therapeutic agents, cancer theranostics, tissue engineering, as well as others. The effective utilization of 2D biomaterials stems from the in-depth knowledge of structure-property-bioactivity-biosafety-application-performance relationships. A comprehensive summary of 2D biomaterials for biomedicine is still lacking. In this comprehensive review, we aim to concentrate on the state-of-the-art 2D biomaterials with a particular focus on their versatile biomedical applications. In particular, we discuss the design, fabrication and functionalization of 2D biomaterials used for diverse biomedical applications based on the up-to-date progress. Furthermore, the interactions between 2D biomaterials and biological systems on the spatial-temporal scale are highlighted, which will deepen the understanding of the underlying action mechanism of 2D biomaterials aiding their design with improved functionalities. Finally, taking the bench-to-bedside as a focus, we conclude this review by proposing the current crucial issues/challenges and presenting the future development directions to advance the clinical translation of these emerging 2D biomaterials.


Assuntos
Disciplinas das Ciências Biológicas , Grafite , Materiais Biocompatíveis , Engenharia Biomédica , Nanotecnologia , Engenharia Tecidual
4.
Bioengineered ; 12(1): 8594-8613, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34607509

RESUMO

COVID-19 is one of the most severe global health crises that humanity has ever faced. Researchers have restlessly focused on developing solutions for monitoring and tracing the viral culprit, SARS-CoV-2, as vital steps to break the chain of infection. Even though biomedical engineering (BME) is considered a rising field of medical sciences, it has demonstrated its pivotal role in nurturing the maturation of COVID-19 diagnostic technologies. Within a very short period of time, BME research applied to COVID-19 diagnosis has advanced with ever-increasing knowledge and inventions, especially in adapting available virus detection technologies into clinical practice and exploiting the power of interdisciplinary research to design novel diagnostic tools or improve the detection efficiency. To assist the development of BME in COVID-19 diagnosis, this review highlights the most recent diagnostic approaches and evaluates the potential of each research direction in the context of the pandemic.


Assuntos
Engenharia Biomédica/métodos , Teste de Ácido Nucleico para COVID-19/métodos , Teste Sorológico para COVID-19/métodos , COVID-19/diagnóstico , Inteligência Artificial , Técnicas Biossensoriais , Sistemas CRISPR-Cas , Humanos , Imunoensaio , Microfluídica , Saúde Pública , SARS-CoV-2
5.
J Vis Exp ; (175)2021 09 22.
Artigo em Inglês | MEDLINE | ID: mdl-34633382

RESUMO

Many developments in biomedical research have been inspired by discovering anatomical and cellular mechanisms that support specific functions in different species. The octopus is one of these exceptional animals that has given scientists new insights into the fields of neuroscience, robotics, regenerative medicine, and prosthetics. Research with this species of cephalopods requires the set-up of complex facilities and intensive care for both the octopus and its ecosystem that is critical for the project's success. This system requires multiple mechanical and biological filtering systems to provide a safe and clean environment for the animal. Along with the control system, specialized routine maintenance and cleaning are required to effectively keep the facility operating long term. It is advised to provide an enriched environment to these intelligent animals by changing the tank's landscape, incorporating a variety of prey, and introducing challenging tasks for them to work through. Our results include MRI and a whole-body autofluorescence imaging as well as behavioral studies to better understand their nervous system. Octopuses possess unique physiology that can impact many areas of biomedical research. Providing them with a sustainable ecosystem is the first crucial step in uncovering their distinct capabilities.


Assuntos
Octopodiformes , Robótica , Animais , Bioengenharia , Engenharia Biomédica , Ecossistema
6.
IEEE Pulse ; 12(5): 24-26, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34714737

RESUMO

Most biomedical engineering students around the country will eventually end up working for a medical device company. For this reason, biomedical engineering capstone design courses should not only provide students with a hands-on design experience, but they should also prepare students for careers in the medical device industry. These courses should be relevant and up to date to reflect current design trends, processes, and practices followed in industry.


Assuntos
Engenharia Biomédica , Currículo , Engenharia Biomédica/educação , Docentes , Humanos , Indústrias , Estudantes
7.
BMC Med Ethics ; 22(1): 130, 2021 09 25.
Artigo em Inglês | MEDLINE | ID: mdl-34563173

RESUMO

In March 2019, the World Health Organization (WHO) declared that humanity was entering a global pandemic phase. This unforeseen situation caught everyone unprepared and had a major impact on several professional categories that found themselves facing important ethical dilemmas. The article revolves around the category of biomedical and clinical engineers, which were among those most involved in dealing with and finding solutions to the pandemic. In hindsight, the major issues brought to the attention of biomedical engineers have raised important ethical implications, such as the allocation of resources, the responsibilities of science and the inadequacy and non-universality of the norms and regulations on biomedical devices and personal protective equipment. These issues, analyzed one year after the first wave of the pandemic, come together in the appeal for responsibility for thought, action and, sometimes, even silence. This highlights the importance of interdisciplinarity and the definitive collapse of the Cartesian fragmentation of knowledge, calling for the creation of more fora, where this kind of discussions can be promoted.


Assuntos
COVID-19 , Equipamento de Proteção Individual , Engenharia Biomédica , Ciências Humanas , Humanos , SARS-CoV-2
8.
Sci Rep ; 11(1): 17885, 2021 09 09.
Artigo em Inglês | MEDLINE | ID: mdl-34504246

RESUMO

We propose a classification method using the radiomics features of CT chest images to identify patients with coronavirus disease 2019 (COVID-19) and other pneumonias. The chest CT images of two groups of participants (90 COVID-19 patients who were confirmed as positive by nucleic acid test of RT-PCR and 90 other pneumonias patients) were collected, and the two groups of data were manually drawn to outline the region of interest (ROI) of pneumonias. The radiomics method was used to extract textural features and histogram features of the ROI and obtain a radiomics features vector from each sample. Then, we divided the data into two independent radiomic cohorts for training (70 COVID-19 patients and 70 other pneumonias patients), and validation (20 COVID-19 patients and 20 other pneumonias patients) by using support vector machine (SVM). This model used 20 rounds of tenfold cross-validation for training. Finally, single-shot testing of the final model was performed on the independent validation cohort. In the COVID-19 patients, correlation analysis (multiple comparison correction-Bonferroni correction, P < 0.05/7) was also conducted to determine whether the textural and histogram features were correlated with the laboratory test index of blood, i.e., blood oxygen, white blood cell, lymphocytes, neutrophils, C-reactive protein, hypersensitive C-reactive protein, and erythrocyte sedimentation rate. The final model showed good discrimination on the independent validation cohort, with an accuracy of 89.83%, sensitivity of 94.22%, specificity of 85.44%, and AUC of 0.940. This proved that the radiomics features were highly distinguishable, and this SVM model can effectively identify and diagnose patients with COVID-19 and other pneumonias. The correlation analysis results showed that some textural features were positively correlated with WBC, and NE, and also negatively related to SPO2H and NE. Our results showed that radiomic features can classify COVID-19 patients and other pneumonias patients. The SVM model can achieve an excellent diagnosis of COVID-19.


Assuntos
COVID-19/diagnóstico por imagem , COVID-19/diagnóstico , Pneumonia/diagnóstico por imagem , Pneumonia/diagnóstico , Máquina de Vetores de Suporte , Tomografia Computadorizada por Raios X/métodos , Adulto , Engenharia Biomédica , Sedimentação Sanguínea , Proteína C-Reativa/análise , COVID-19/patologia , Feminino , Humanos , Contagem de Leucócitos , Pulmão/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Pneumonia/patologia , SARS-CoV-2
9.
Nat Methods ; 18(9): 985, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34413524
10.
Biomed Pharmacother ; 142: 111953, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34343897

RESUMO

Currently, there are over 230 different COVID-19 vaccines under development around the world. At least three decades of scientific development in RNA biology, immunology, structural biology, genetic engineering, chemical modification, and nanoparticle technologies allowed the accelerated development of fully synthetic messenger RNA (mRNA)-based vaccines within less than a year since the first report of a SARS-CoV-2 infection. mRNA-based vaccines have been shown to elicit broadly protective immune responses, with the added advantage of being amenable to rapid and flexible manufacturing processes. This review recapitulates current advances in engineering the first two SARS-CoV-2-spike-encoding nucleoside-modified mRNA vaccines, highlighting the strategies followed to potentiate their effectiveness and safety, thus facilitating an agile response to the current COVID-19 pandemic.


Assuntos
Engenharia Biomédica , Vacinas contra COVID-19 , COVID-19 , Desenvolvimento de Medicamentos/métodos , Descoberta de Drogas/métodos , SARS-CoV-2 , Engenharia Biomédica/métodos , Engenharia Biomédica/tendências , COVID-19/prevenção & controle , COVID-19/virologia , Vacinas contra COVID-19/classificação , Vacinas contra COVID-19/farmacologia , Sistemas de Liberação de Medicamentos/métodos , Humanos , Imunogenicidade da Vacina , Lipossomos/farmacologia , Nanopartículas , Nucleosídeos/farmacologia , Nucleosídeos/fisiologia , SARS-CoV-2/efeitos dos fármacos , SARS-CoV-2/imunologia , Glicoproteína da Espícula de Coronavírus/imunologia , Vacinas Sintéticas/farmacologia
12.
Regen Med ; 16(8): 775-802, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34427104

RESUMO

The concept of tissue engineering involves regeneration and repair of damaged tissue and organs using various combinations of cells, growth factors and scaffolds. The extracellular matrix (ECM) forms the integral part of the scaffold to induce cell proliferation thereby leading to new tissue formation. Decellularization technique provides decellularized ECM (dECM), free of cells while preserving the in vivo biomolecules. In this review, we focus on the detailed methodology of diverse decellularization techniques for various organs of different animals, and the biomedical applications employing the dECM. A culmination of different methods of decellularization is optimized, which offers a suitable microenvironment mimicking the native in vivo topography for in vitro organ regeneration. A detailed assessment of the dECM provides information on the microarchitecture, presence of ECM proteins, biocompatibility and cell proliferation. dECM has also been processed as scaffolds and drug-delivery vehicles, and utilized for regeneration.


Assuntos
Engenharia Biomédica , Tecidos Suporte , Animais , Matriz Extracelular , Engenharia Tecidual
13.
Adv Healthc Mater ; 10(20): e2100972, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34369098

RESUMO

For the majority of patients with severe corneal injury or disease, corneal transplantation is the only suitable treatment option. Unfortunately, the demand for donor corneas greatly exceeds the availability. To overcome shortage issues, a myriad of bioengineered constructs have been developed as mimetics of the corneal stroma over the last few decades. Despite the sheer number of bioengineered stromas developed , these implants fail clinical trials exhibiting poor tissue integration and adverse effects in vivo. Such shortcomings can partially be ascribed to poor biomechanical performance. In this review, existing approaches for bioengineering corneal stromal constructs and their mechanical properties are described. The information collected in this review can be used to critically analyze the biomechanical properties of future stromal constructs, which are often overlooked, but can determine the failure or success of corresponding implants.


Assuntos
Substância Própria , Transplante de Córnea , Bioengenharia , Engenharia Biomédica , Córnea , Humanos , Engenharia Tecidual
14.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 52(4): 566-569, 2021 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-34323032

RESUMO

Biomedical engineering (BME) (biomedical materials track) is a typical field of interdisciplinary integration. Its specialty education simultaneously undertakes the duo reformation responsibilities for the new engineering education and the new medical education due to its unique strengths in interdisciplinary nature, comprehensive scope of knowledge, and status of being on the cutting edge of technology. We made an analysis, in this paper, of the opportunities and challenges faced by BME (biomedical materials track) specialty education on the basis of the trends and frontiers of development in biomedical materials in the world. From the perspective of new requirements raised by major national strategies and industrial development for the qualifications and competence of professionals specializing in biomedical materials, thorough reflections were made on the specialized education of BME (biomedical materials track) under the background of the new engineering education and the new medical education. Furthermore, we proposed herein to reconstruct the specialized core knowledge system according to the main line of the reactions and the responses between the biomedical materials and human bodies at different levels and set up a series of courses of biomedical materials science centered on Materiobiology as the core. We also proposed to establish a diversified integrated reform model of the training system incorporating production, learning, research and application for highly competent BME (biomedical materials track) professionals. This paper attempts to contribute to the solution of the major issue of how to train the innovative talents and leaders who will pioneer a new round of diagnosis and treatment technology revolution and the development of the medical device industry.


Assuntos
Engenharia Biomédica , Universidades , Engenharia Biomédica/educação , Currículo , Humanos , Aprendizagem
15.
Nat Commun ; 12(1): 4395, 2021 07 20.
Artigo em Inglês | MEDLINE | ID: mdl-34285224

RESUMO

The unique properties of self-healing materials hold great potential in the field of biomedical engineering. Although previous studies have focused on the design and synthesis of self-healing materials, their application in in vivo settings remains limited. Here, we design a series of biodegradable and biocompatible self-healing elastomers (SHEs) with tunable mechanical properties, and apply them to various disease models in vivo, in order to test their reparative potential in multiple tissues and at physiological conditions. We validate the effectiveness of SHEs as promising therapies for aortic aneurysm, nerve coaptation and bone immobilization in three animal models. The data presented here support the translation potential of SHEs in diverse settings, and pave the way for the development of self-healing materials in clinical contexts.


Assuntos
Implantes Absorvíveis , Materiais Biocompatíveis/uso terapêutico , Engenharia Biomédica , Poliuretanos/uso terapêutico , Animais , Aneurisma Aórtico/cirurgia , Materiais Biocompatíveis/química , Modelos Animais de Doenças , Elastômeros/química , Fixação de Fratura/métodos , Fraturas Ósseas/cirurgia , Humanos , Masculino , Teste de Materiais , Camundongos , Transferência de Nervo/métodos , Traumatismos dos Nervos Periféricos/cirurgia , Poliuretanos/química , Ratos , Suínos , Porco Miniatura
16.
Biomed Res Int ; 2021: 9962905, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34235225

RESUMO

The rapid progress of the combination of medicine and engineering provides better chances for the clinical treatment and healthcare engineering. Traumatic brain injury (TBI) and its related symptoms have become a major global health problem. At present, these techniques has been widely used in the rehabilitation of TBI. In this review article, we summarizes the progress of the combination of medicine and industry in the rehabilitation of traumatic brain injury in recent years, mainly from the following aspects: artificial intelligence (AI), brain-computer interfaces (BCI), noninvasive brain stimulation (NIBS), and wearable-assisted devices. We believe the summary of this article can improve insight into the combination of medicine and industry in the rehabilitation of traumatic brain injury.


Assuntos
Inteligência Artificial , Lesões Encefálicas Traumáticas/reabilitação , Interfaces Cérebro-Computador , Reabilitação/instrumentação , Reabilitação/métodos , Engenharia Biomédica/métodos , Lesões Encefálicas Traumáticas/terapia , Estimulação Encefálica Profunda , Humanos , Robótica , Software , Telemedicina , Estimulação Magnética Transcraniana , Realidade Virtual , Dispositivos Eletrônicos Vestíveis
17.
Bioengineered ; 12(1): 2274-2287, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34077310

RESUMO

Xuebijing Injection have been found to improve the clinical symptoms of COVID-19 and alleviate disease severity, but the mechanisms are currently unclear. This study aimed to investigate the potential molecular targets and mechanisms of the Xuebijing injection in treating COVID-19 via network pharmacology and molecular docking analysis. The main active ingredients and therapeutic targets of the Xuebijing injection, and the pathogenic targets of COVID-19 were screened using the TCMSP, UniProt, and GeneCard databases. According to the 'Drug-Ingredients-Targets-Disease' network built by STRING and Cytoscape, AKT1 was identified as the core target, and baicalein, luteolin, and quercetin were identified as the active ingredients of the Xuebijing injection in connection with AKT1. R language was used for enrichment analysis that predict the mechanisms by which the Xuebijing injection may inhibit lipopolysaccharide-mediated inflammatory response, modulate NOS activity, and regulate the TNF signal pathway by affecting the role of AKT1. Based on the results of network pharmacology, a molecular docking was performed with AKT1 and the three active ingredients, the results indicated that all three active ingredients could stably bind with AKT1. These findings identify potential molecular mechanisms by which Xuebijing Injection inhibit COVID-19 by acting on AKT1.


Assuntos
Antivirais/administração & dosagem , COVID-19/tratamento farmacológico , COVID-19/metabolismo , Medicamentos de Ervas Chinesas/administração & dosagem , SARS-CoV-2 , Antivirais/farmacocinética , Antivirais/farmacologia , Engenharia Biomédica , Medicamentos de Ervas Chinesas/farmacocinética , Medicamentos de Ervas Chinesas/farmacologia , Flavanonas/administração & dosagem , Humanos , Injeções , Luteolina/administração & dosagem , Simulação de Acoplamento Molecular , Pandemias , Ligação Proteica , Mapas de Interação de Proteínas , Proteínas Proto-Oncogênicas c-akt/química , Proteínas Proto-Oncogênicas c-akt/efeitos dos fármacos , Proteínas Proto-Oncogênicas c-akt/metabolismo , Quercetina/administração & dosagem , Transdução de Sinais/efeitos dos fármacos
18.
Sensors (Basel) ; 21(9)2021 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-34063000

RESUMO

Decision-making is an important part of human life and particularly in any engineering process related to a complex product. New sensors and actuators based on MEMS technologies are increasingly complex and quickly evolving into products. New biomedical implanted devices may benefit from system engineering approaches, previously reserved to very large projects, and it is expected that this need will increase in the future. Here, we propose the application of Model Based Systems Engineering (MBSE) to systematize and optimize the trade-off analysis process. The criteria, their utility functions and the weighting factors are applied in a systematic way for the selection of the best alternative. Combining trade-off with MBSE allow us to identify the more suitable technology to be implemented to transfer energy to an implanted biomedical micro device.


Assuntos
Sistemas de Liberação de Medicamentos , Próteses e Implantes , Engenharia Biomédica , Engenharia , Humanos , Tecnologia sem Fio
19.
IEEE Pulse ; 12(3): 21-23, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34156930

RESUMO

In the wake of the COVID-19 pandemic, the need for rapid and accurate diagnostic testing across populations quickly became evident. In response, the National Institutes of Health (NIH) was determined not only to invest heavily in this area but to change the process by which grant proposals were reviewed and funded in order to spur faster development of viable technologies. The Rapid Acceleration of Diagnostics (RADx) initiative was designed to speed innovation, commercialization, and implementation of potential COVID-19 diagnostic technology. As part of this effort, the RADx Tech initiative focuses on the development, validation, and commercialization of innovative point-of-care, home-based, and clinical lab-based tests that can detect SARS-CoV-2. This effort was enabled through the NIH's National Institute of Biomedical Imaging and Bioengineering (NIBIB) Point-of-Care Technology Research Network (POCTRN).


Assuntos
Engenharia Biomédica/economia , Teste para COVID-19/economia , COVID-19 , National Institutes of Health (U.S.)/economia , Pandemias , Sistemas Automatizados de Assistência Junto ao Leito/economia , SARS-CoV-2 , Engenharia Biomédica/tendências , COVID-19/diagnóstico , COVID-19/economia , COVID-19/epidemiologia , Humanos , Estados Unidos
20.
Ann Biomed Eng ; 49(7): 1593-1597, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34085126

RESUMO

Robotics, once combined with cold atmospheric plasma, represent key elements of the next generation of personalized medicine and contribute to the effective yet immediate response to pandemics. Plasma robots can serve as CAP delivery vehicle to assist in tumor therapeutics and viral disease prevention in addition to the already prevalent utilities of robots in precision surgery, diagnosis, and risk prevention. Plasma robots may develop at either the macro- or the micro- scale, successful navigations at which require joint effort from multiple research domains.


Assuntos
COVID-19/prevenção & controle , Gases em Plasma/uso terapêutico , Medicina de Precisão/métodos , Robótica/métodos , SARS-CoV-2 , Engenharia Biomédica/métodos , Gerenciamento Clínico , Humanos , Pandemias , Gases em Plasma/administração & dosagem , Medicina de Precisão/tendências , Robótica/instrumentação
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...