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1.
Zhongguo Zhen Jiu ; 42(9): 1041-3, 2022 Sep 12.
Artigo em Chinês | MEDLINE | ID: mdl-36075602

RESUMO

The clinical experience of He's three-clear method by stages for herpes zoster on the head and face is summarized. The strong-clear method (blood-letting therapy) combined with mild-clear method (acupuncture with filiform needle) are applied for the acute pain period and subacute pain period of herpes zoster on the head and face. For acute pain period, the bleeding volume should be large (more than 10 mL), and treatment is given once every other day; for the subacute pain period, the bleeding volume should be 5-10 mL, and treatment is given 2-3 times a week. In the chronic pain period, the fire needle of the warm-clear method combined with mild-clear method (acupuncture with filiform needle) are applied for the syndrome of qi-stagnation and blood-stasis, while the warm acupuncture of the warm-clear method combined with mild-clear method (acupuncture with filiform needle) ware applied for the syndrome of qi-deficiency yin-injury blood-stasis.


Assuntos
Terapia por Acupuntura , Dor Aguda , Herpes Zoster , Sangria , Herpes Zoster/terapia , Humanos , Hiperplasia , Agulhas
2.
J Paediatr Child Health ; 58(9): 1571-1577, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35657084

RESUMO

AIM: Our study aims to analyse the effect of using a vacutainer with cartoon characters on preschoolers' pain and fear levels during the bloodletting process. METHODS: The experimental, randomised controlled clinical trial was conducted with 102 children aged 3-6 years, randomised into control and experimental groups. The bloodletting routine was applied to the control group. The vacutainer of each child in the experimental group was covered with the illustration of their chosen cartoon character and blood was drawn with it. The fear and pain levels during the bloodletting procedure were examined in both groups. RESULTS: Pain and fear levels were significantly lower in the experimental group than in the experimental group (P < 0.05). CONCLUSIONS: Our research highlighted that using a cartoon character sticker with a vacutainer can reduce preschoolers' pain and fear during bloodletting.


Assuntos
Sangria , Dor , Criança , Medo , Humanos , Manejo da Dor/métodos
3.
Zhongguo Zhen Jiu ; 42(6): 629-33, 2022 Jun 12.
Artigo em Chinês | MEDLINE | ID: mdl-35712946

RESUMO

OBJECTIVE: To observe the clinical efficacy of different treatment frequency of auricular bloodletting combined with auricular point sticking for acne vulgaris. METHODS: A total of 90 patients with acne vulgaris were randomized into a treatment group 1 (30 cases, 2 cases dropped off), a treatment group 2 (30 cases, 4 cases dropped off) and a treatment group 3 (30 cases, 5 cases dropped off). Combination therapy of auricular bloodletting and auricular point sticking at Fei (CO14), Shenmen (TF4), Neifenmi (CO18) and Shenshangxian (TG2p) were given once a week, twice a week and 3 times a week in the treatment group 1, the treatment group 2 and the treatment group 3 respectively, 4 weeks were as one course and totally 3 courses were required in the 3 groups. Before treatment and after 1, 2, 3 courses of treatment, the scores of global acne grading system (GAGS), skin lesion and quality of life-acne (QoL-Acne) were observed, the clinical efficacy was evaluated after 3 courses of treatment and the recurrence rate was evaluated in follow-up of 1 month after treatment in the 3 groups. RESULTS: Compared before treatment, the scores of GAGS and skin lesion were decreased at each time point in the 3 groups (P<0.05), the QoL-Acne scores were increased after 1 course of treatment in the treatment group 3 and after 2, 3 courses of treatment in the 3 groups (P<0.05). There were no statistical differences in scores of GAGS, skin lesion and QoL-Acne among the 3 groups (P>0.05). There were no statistical differences in effective rate and recurrence rate among the 3 groups (P>0.05). CONCLUSION: Different frequency of auricular bloodletting combined with auricular point sticking have similar efficacy in treating acne vulgaris, all can improve the skin lesion and quality of life in patients with acne vulgaris, and have a cumulative effect and good long-term curative effect.


Assuntos
Acne Vulgar , Acupuntura Auricular , Acne Vulgar/terapia , Pontos de Acupuntura , Sangria , Humanos , Qualidade de Vida , Resultado do Tratamento
4.
Zhongguo Zhen Jiu ; 42(2): 157-61, 2022 Feb 12.
Artigo em Chinês | MEDLINE | ID: mdl-35152579

RESUMO

OBJECTIVE: To compare the clinical therapeutic effect and the impacts on recurrence rate on chronic spontaneous urticaria (CSU) between the combined treatment of bloodletting therapy and auricular point sticking on the base of xuanfu theory and the oral solution of levocetirizine hydrochloride. METHODS: A total of 86 patients with CSU were randomized into an observation group (43 cases, 1 case dropped off) and a control group (43 cases, 3 cases dropped off). In the observation group, bloodletting therapy at Dazhui (GV 14), Feishu (BL 13), Geshu (BL 17) and Pishu (BL 20) was combined with auricular point sticking at lung (CO14), kidney (CO10), shenmen (TF4) and heart (CO15), etc. This combined treatment was given once every two days. In the control group, the oral solution of levocetirizine hydrochloride was prescribed, 10 mL each time, once daily. The treatment lasted for 4 weeks in the two groups. Before and after treatment, urticaria activity score 7 (UAS7), the score of dermatology life quality index (DLQI) and the levels of serum immune globulin E (IgE), interleukin 4 (IL-4) and interferon γ (IFN-γ) were compared in the patients between the two groups. The clinical therapeutic effect was evaluated in patients of the two groups and the recurrence rate was followed up 4, 8 and 12 weeks after treatment separately. RESULTS: After treatment, the scores of UAS7 and DLQI, as well as the levels of serum IgE and IL-4 were all reduced as compared with those before treatment in the two groups (P<0.05), and the level of serum IFN-γ was increased (P<0.05). The total effective rate was 83.3% (35/42) in the observation group and was 85.0% (34/40) in the control group. There was no statistical significance for the difference in the clinical therapeutic effect between the two groups (P>0.05). Eight and 12 weeks after treatment, the recurrence rates were 21.1% (4/19) and 26.3% (5/19) in the observation group, lower than 55.0% (11/20) and 65.0% (13/20) in the control group, respectively (P<0.05). CONCLUSION: The combined therapy of bloodletting and auricular point sticking on the base of xuanfu theory relieves the clinical symptoms, regulates the levels of serum IgE, IL-4 and IFN-γ and improves the quality of life in the patients with CSU. The clinical therapeutic effect of this combined treatment is similar to the oral solution of levocetirizine hydrochloride. But, the recurrence rate of the combined treatment of bloodletting and auricular point sticking is lower and its long-term curative effect is better.


Assuntos
Terapia por Acupuntura , Acupuntura Auricular , Urticária Crônica , Pontos de Acupuntura , Sangria , Humanos , Qualidade de Vida , Resultado do Tratamento
5.
Complement Ther Clin Pract ; 46: 101503, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34814062

RESUMO

BACKGROUND: Bloodletting therapy (BLT) is widely used to relieve acute gouty arthritis (AGA). However, limited evidence-based reports exist on the effectiveness and safety of BLT. This systematic review aims to evaluate the feasibility and safety of BLT in treating AGA. METHODS: Seven databases were exhaustively screened from the date of establishment to July 31, 2020, irrespective of the publication source and language. The included articles were evaluated for bias risk by using the Cochrane risk of bias assessment tool. All statistical analyses were done with Review Manager 5.3. RESULTS: Twelve studies involving 894 participants were included for the final analysis. Our meta-analysis revealed that BLT was highly effective in relieving pain (MD = -1.13, 95% CI [-1.60, -0.66], P < 0.00001), with marked alterations in the total effective (RR = 1.09, 95% [1.05, 1.14], P < 0.0001) and curative rates (RR = 1.37, 95%CI [1.17, 1.59], P < 0.0001). In addition, BLT could dramatically reduce serum C-reactive protein (CRP) level (MD = -3.64, 95%CI [-6.72, -0.55], P = 0.02). Both BLT and Western medicine (WM) produced comparable decreases in uric acid (MD = -18.72, 95%CI [-38.24, 0.81], P = 0.06) and erythrocyte sedimentation rate (ESR) levels (MD = -3.01, 95%CI [-6.89, 0.86], P = 0.13). Lastly, we demonstrated that BLT was safer than WM in treating AGA (RR = 0.36, 95%CI [0.13, 0.97], P = 0.04). CONCLUSION: BLT is effective in alleviating pain and decreasing CRP level in AGA patients with a lower risk of evoking adverse reactions.


Assuntos
Artrite Gotosa , Artrite Gotosa/terapia , Sangria , Humanos , Resultado do Tratamento
6.
Dis Markers ; 2021: 3295021, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34737837

RESUMO

OBJECTIVES: The aim of this study was to explore, whether treatment with bloodletting at Shaoshang and Shangyang acupuncture points would affect therapy outcome and prognosis for severe community-acquired pneumonia (SCAP) in the elderly. METHODS: A total of 62 patients, who met the diagnostic criteria for SCAP, were enrolled in the study and randomly divided into two groups, i.e., treatment group (n = 31) and control group (n = 31). All patients received a therapy according to the Chinese Clinical Practice and Expert Consensus of Emergency Severe Pneumonia from 2016. In addition to that, a bloodletting at Shaoshang (LU11) and Shangyang (LI1) acupuncture points was applied for the treatment group. This intervention was repeated for three times (ones daily), bloodletting a volume of 2-3 ml at each time point. Differences in a main index of clinical efficacy, body temperature (T), respiratory rate (RR), heart rate (Hr), white blood cell count (WBC), neutrophil percentage (N%), and C-reactive protein level (CRP) as well as different scores (CURB-65 score, SOFA score, and Apache II score) were compared between groups. Moreover, the 28-day mortality was compared between treatment and control group. The statistical methods involved in carrying out the current study include t-test, Wilcoxon test, and chi-square test. RESULTS: The clinical effective rate of the treatment group was 82.9%, which was significantly higher than the 17.1% in the control group (P < 0.05). After finishing the intervention, the treatment group showed significantly lower T (37.28 ± 0.54 vs. 37.82 ± 0.81), RR (20.06 ± 2.67 vs. 23.71 ± 6.85), Hr (81.71 ± 10.38 vs. 93.84 ± 15.39), CUBR-65 score (2.16 ± 0.74 vs. 3.03 ± 0.98), and SOFA score (5.84 ± 3.83 vs. 8.16 ± 4.2) compared to the control group (P < 0.05). The 28-day mortality rate of the treatment group was significantly lower than in the control group (12.9% vs. 45.2%, P = 0.05). CONCLUSIONS: Bloodletting at Shaoshang and Shangyang acupuncture points can support improving the clinical treatment efficacy for SCAP and reduce the 28-day mortality rate in the elderly.


Assuntos
Pontos de Acupuntura , Sangria/métodos , Infecções Comunitárias Adquiridas/terapia , Pneumonia/terapia , Idoso , Idoso de 80 Anos ou mais , Sangria/efeitos adversos , Feminino , Humanos , Masculino
7.
Sci Rep ; 11(1): 22097, 2021 11 11.
Artigo em Inglês | MEDLINE | ID: mdl-34764381

RESUMO

Normoferritinemic women with functional hyperandrogenism show a mild iron overload. Iron excess, hyperandrogenism, and cardioautonomic dysfunction contribute to blood pressure (BP) abnormalities in these patients. Furthermore, combined oral contraceptives (COC) prescribed for hyperandrogenic symptoms may worse BP recordings. Iron depletion by phlebotomy appears to lower BP in other acquired iron overload conditions. We aimed to determine the effect of iron depletion on the office BP, ambulatory BP monitoring, and frequency of hypertension in patients with functional hyperandrogenism submitted to standard therapy with COC. We conducted a phase 2 randomized, controlled, parallel, open-label clinical trial (NCT02460445) in adult women with functional hyperandrogenism including hyperandrogenic polycystic ovary syndrome and idiopathic hyperandrogenism. After a 3-month run-in period of treatment with 35 µg ethinylestradiol plus 2 mg cyproterone acetate, participants were randomized (1:1) to three scheduled bloodlettings or observation for another 9 months. Main outcome measures were the changes in office BP, 24-h-ambulatory BP, and frequency of hypertension in both study arms. From June 2015 to June 2019, 33 women were included in the intention-to-treat analyses. We observed an increase in mean office systolic BP [mean of the differences (MD): 2.5 (0.3-4.8) mmHg] and night-time ambulatory systolic BP [MD 4.1 (1.4-6.8) mmHg] after 3 months on COC. The percentage of nocturnal BP non-dippers also increased, from 28.1 to 92.3% (P < 0.001). Office and ambulatory BP did not change throughout the experimental period of the trial, both when considering all women as a whole or as a function of the study arm. The frequency of the non-dipping pattern in BP decreased during the experimental period [OR 0.694 (0.577-0.835), P < 0.001], regardless of the study arm. Decreasing iron stores by scheduled bloodletting does not override the BP abnormalities caused by COC in women with functional hyperandrogenism.


Assuntos
Pressão Sanguínea/efeitos dos fármacos , Anticoncepcionais Orais Combinados/uso terapêutico , Hiperandrogenismo/tratamento farmacológico , Adulto , Pressão Sanguínea/fisiologia , Monitorização Ambulatorial da Pressão Arterial/métodos , Sangria/métodos , Acetato de Ciproterona/uso terapêutico , Combinação de Medicamentos , Etinilestradiol/uso terapêutico , Feminino , Humanos , Hiperandrogenismo/fisiopatologia , Hipertensão/fisiopatologia , Síndrome do Ovário Policístico/tratamento farmacológico , Síndrome do Ovário Policístico/fisiopatologia , Adulto Jovem
8.
J Hist Dent ; 69(1): 69, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34383638

RESUMO

Very few "Dentist AND Cupper" trade cards are known and this is the only illustrated one known to the authors. "Mr. Glissan, Dentist and Cupper, 147 Blackfriars Road, (London), Teeth extracted for the Poor Gratuitously." Above the text and in the center is a eight-sided brass boxed scarificator. Developed in the 18th century as a more humane and efficient instrument for bloodletting than lancets or fleams, scarificators had multiple blades that shot out with the press of a spring-loaded lever creating an instantaneous series of parallel cuts in the skin of the patient. After the cuts were made a warm glass cup (to create a vacuum) was applied to drain blood. Two of these cups are pictured on each side of the scarificator. A mandible to the left and a maxilla to the right are also pictured. An explanation of the ancient procedure of cupping can be accessed at: https://www.webmd.com/balance/guide/cupping-therapy#1 (accessed 30 October 2020). Mr. Glessan's offer of free extractions for the poor is not unknown but seldom found on early dentist's trade cards.


Assuntos
Ciências Humanas , Mandíbula , Sangria , Odontólogos , Humanos , Maxila
9.
Zhongguo Zhen Jiu ; 41(7): 813-7, 2021 Jul 12.
Artigo em Chinês | MEDLINE | ID: mdl-34259418

RESUMO

The relevant provisions of bloodletting for expelling pathogens are collected from the works of the medical representative scholars in Jin-Yuan Dynasties and Ming-Qing Dynasties respectively to construct the databases of bloodletting for expelling pathogens of Jin-Yuan Dynasties and Ming-Qing Dynasties. Using frequency analysis, the bloodletting device, bloodletting location, bloodletting volume, the related pathogens and indications are compared between these two times so that the evidences could be provided for the inheritance and development of the academic thought of bloodletting for expelling pathogens. It is found that the three-edge needle is the most commonly used device for bloodletting in Jin-Yuan Dynasties and Ming-Qing Dynasties and yang meridians and local affected area are generally selected for bloodletting. The range of meridian and acupoint selection in Ming-Qing Dynasties are more extensive than those in Jin-Yuan Dynasties, while bloodletting volume is less than that in Jin-Yuan Dynasties. In Jin-Yuan Dynasties, bloodletting therapy is mainly for expelling exogenous pathogens i.e. heat, fire and wind, while, in Ming-Qing Dynasties, this therapy is specially for clearing heat and removing stasis. The disorders of internal medicine are often treated with such therapy in these two dynasties. But, compared with Jin-Yuan Dynasties, the indication of bloodletting therapy is expanded gradually in Ming-Qing Dynasties. It is shown that the academic thought of bloodletting for expelling pathogens in Jin-Yuan Dynasties is inherited and developed from Ming-Qing Dynasties.


Assuntos
Medicina Tradicional Chinesa , Meridianos , Pontos de Acupuntura , Sangria , China , Agulhas
10.
J Clin Epidemiol ; 138: 139-146, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34186196

RESUMO

OBJECTIVE: To estimate iron losses and disease severity following 19th century bloodletting in patients with pneumonia. STUDY DESIGN AND SETTING: Benefits of bloodletting in pneumonia patients were contested during the 19th century. Although large blood volumes during infection were removed there was no systematic data collection assessing efficacy and knowledge of iron composition of blood was rudimentary. This observational analysis of historical data quantifies iron losses in pneumonia cases in relation to disease severity. RESULTS: Based on one detailed case series average blood volume removed for survivors was 830 mL (range 114-2272 mL), and mean recovery times were shorter in patients bled within 2 days of illness (P < 0.001). Average iron removed was 446 mg with phlebotomy done ≤2 days of illness presentation and 347 mg after >2 days of illness (P = 0.012). Across several European hospitals average case fatality in pneumonia patients receiving phlebotomy was higher than in those treated without phlebotomy (19.9% vs. 12.8%, OR 1.55, 95% CI 1.38-1.74, P < 0.001). CONCLUSION: Variable efficacy for bloodletting could at least in part be explained by altered iron status.


Assuntos
Sangria/história , Sangria/mortalidade , Ferro/sangue , Pneumonia/história , Pneumonia/mortalidade , Pneumonia/terapia , Adulto , Sangria/métodos , Feminino , História do Século XX , Humanos , Masculino , Pessoa de Meia-Idade
11.
Medicine (Baltimore) ; 100(22): e26169, 2021 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-34087878

RESUMO

BACKGROUND: The study aims to evaluate the effectiveness and safety of bloodletting therapy for herpes zoster. METHODS: The following electronic databases will be searched from PubMed (1966 to March 2020), the Cochrane Central Register of Controlled Trials (update to March 2020), EMBASE (1980 to March 2020), China National Knowledge Infrastructure (1979 to March 2020), Wan Fang Data (1980 to March 2020), Chinese Scientific Journal Database (1989 to March 2020), Chinese Biomedical Database (1978 to March 2020) and traditional Chinese medicine Literature Analysis and Retrieval Database (1949 to March 2020). All randomized controlled trials without any limitation of blinding or publication language about this topic will be included, exclude cohort studies and case reports. Two independent researchers will operate article retrieval, duplication removing, screening, quality evaluation, and data analyses by Review Manager (V.5.3.5). Meta-analyses, subgroup analysis, and/or descriptive analysis will be performed based on the included data conditions. RESULTS: High-quality synthesis and/or descriptive analysis of current evidence will be provided from cure rate, converting to clinical diagnosis rate, and side effects of bloodletting. CONCLUSION: This study will provide the evidence of whether bloodletting is an effective and safe intervention for herpes zoster. PROSPERO REGISTRATION NUMBER: CRD42020171976.


Assuntos
Sangria/métodos , Herpes Zoster/terapia , Medicina Tradicional Chinesa/métodos , Sangria/efeitos adversos , Gerenciamento de Dados , Feminino , Herpes Zoster/virologia , Herpesvirus Humano 3/efeitos dos fármacos , Herpesvirus Humano 3/isolamento & purificação , Humanos , Masculino , Medicina Tradicional Chinesa/efeitos adversos , Ensaios Clínicos Controlados Aleatórios como Assunto , Segurança , Resultado do Tratamento
12.
Zhongguo Zhen Jiu ; 41(4): 421-3, 2021 Apr 12.
Artigo em Chinês | MEDLINE | ID: mdl-33909364

RESUMO

Professor WANG Lin-peng's clinical experience in treatment of stroke by acupuncture based on Zhuxie (clearing away pathogenic factors) theory is summarized. According to the pathogens nature of stroke patients (wind, fire, phlegm, blood stasis, asthenia) and the relationship between pathogenic qi and the antipathogenic qi, distinguishing the relationship between the main and secondary pathogenic factors, different acupuncture programs are determined. The filiform needle acupuncture, fire needle acupuncture, bloodletting therapy and other acupuncture methods are used to achieve the treatment objectives of clearing wind, fire, phlegm, blood stasis and strengthening the body.


Assuntos
Terapia por Acupuntura , Acupuntura , Acidente Vascular Cerebral , Pontos de Acupuntura , Sangria , Humanos , Agulhas , Acidente Vascular Cerebral/terapia
13.
QJM ; 114(10): 685-686, 2021 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-33880562

Assuntos
Sangria , Humanos
14.
Transfusion ; 61(3): 673-677, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33580971

RESUMO

BACKGROUND: Therapeutic phlebotomy (TP) is a well-established medical intervention that evolved from the historical practice of bloodletting. METHODS: Patients who require TP are not infrequently told by their health-care providers to "just go donate blood," but TP should always be offered in the context of a prescribed course of therapy. Providers can prescribe a course of TP for a number of indications, including hereditary hemochromatosis, polycythemia vera, iron overload, and testosterone replacement therapy. RESULTS: A course of prescribed TP specifies that patients can be phlebotomized more frequently than volunteer blood donors and reassures patients that TP is being performed per the orders of their provider. Prescribed TP also facilitates two-way communication between the referring provider and the transfusion medicine (TM) physician overseeing the TP. The College of American Pathologists TM checklist describes several requirements regarding the documentation and performance of TP, and electronic medical record systems can be used to demonstrate compliance with these requirements. CONCLUSIONS: TM physicians should discuss the advantages of prescribing TP with providers who mutually care for patients requiring this intervention.


Assuntos
Hemocromatose/terapia , Flebotomia/métodos , Doadores de Sangue , Sangria , Registros Eletrônicos de Saúde , Pessoal de Saúde , Hemocromatose/congênito , Humanos , Sobrecarga de Ferro/terapia , Médicos , Policitemia Vera/terapia
15.
Chin J Integr Med ; 27(4): 291-299, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33515398

RESUMO

OBJECTIVE: To investigate whether blood-brain barrier (BBB) served a key role in the edema-relief effect of bloodletting puncture at hand twelve Jing-well points (HTWP) in traumatic brain injury (TBI) and the potential molecular signaling pathways. METHODS: Adult male Sprague-Dawley rats were assigned to the sham-operated (sham), TBI, and bloodletting puncture (bloodletting) groups (n=24 per group) using a randomized number table. The TBI model rats were induced by cortical contusion and then bloodletting puncture were performed at HTWP twice a day for 2 days. The neurological function and cerebral edema were evaluated by modified neurological severity score (mNSS), cerebral water content, magnetic resonance imaging and hematoxylin and eosin staining. Cerebral blood flow was measured by laser speckles. The protein levels of aquaporin 4 (AQP4), matrix metalloproteinases 9 (MMP9) and mitogen-activated protein kinase pathway (MAPK) signaling were detected by immunofluorescence staining and Western blot. RESULTS: Compared with TBI group, bloodletting puncture improved neurological function at 24 and 48 h, alleviated cerebral edema at 48 h, and reduced the permeability of BBB induced by TBI (all P<0.05). The AQP4 and MMP9 which would disrupt the integrity of BBB were downregulated by bloodletting puncture (P<0.05 or P<0.01). In addition, the extracellular signal-regulated kinase (ERK) and p38 signaling pathways were inhibited by bloodletting puncture (P<0.05). CONCLUSIONS: Bloodletting puncture at HTWP might play a significant role in protecting BBB through regulating the expressions of MMP9 and AQP4 as well as corresponding regulatory upstream ERK and p38 signaling pathways. Therefore, bloodletting puncture at HTWP may be a promising therapeutic strategy for TBI-induced cerebral edema.


Assuntos
Edema Encefálico , Lesões Encefálicas Traumáticas , Animais , Sangria , Edema Encefálico/terapia , Lesões Encefálicas Traumáticas/complicações , Lesões Encefálicas Traumáticas/terapia , Sistema de Sinalização das MAP Quinases , Masculino , Proteínas Quinases Ativadas por Mitógeno , Ratos , Ratos Sprague-Dawley
17.
Chin J Integr Med ; 27(8): 570-577, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32946039

RESUMO

OBJECTIVE: To assess the effect and safety of bloodletting puncture at hand twelve Jing-Well points (HTWPs) in acute stroke patients with conscious disturbance. METHODS: In this multi-center and randomized controlled trial, 360 patients suffered from ischemic or hemorrhagic stroke with conscious disturbance within 48 h from the onset of symptom were divided into bloodletting (180 cases) and control (180 cases) groups using a block randomization. Patients in both groups received routine Western medicine, and patients in the bloodletting group received additional bloodletting puncture at HTWPs on admission immediately before conventional treatment. The primary outcome measure was Glasgow Coma Scale (GCS) score and the secondary outcomes included blood pressure, respiratory rate and pulse rate. All variables were evaluated at baseline (before bloodletting), 0 (after bloodletting immediately), 15, 30, 50 and 80 min post bloodletting. RESULTS: At 80 min post bloodletting, the proportion of patients with improved consciousness in the bloodletting group was greater than the control group (P<0.05). In the separate analysis of moderate consciousness disturbance subgroup, bloodletting therapy benefited ischemic patients, and improved the eye and language response of GCS score at 15, 30, 50, 80 min post bloodletting (P<0.05 or P<0.01). No significant differences were observed regarding the secondary outcomes between two groups (P>0.05). CONCLUSION: The bloodletting puncture at HTWPs was safe and could improve conscious levels of ischemic stroke patients, highlighting a first-aid intervention for acute stroke. (Registration No. ChiCTR-INR-16009530).


Assuntos
Sangria , Acidente Vascular Cerebral , Pontos de Acupuntura , Estado de Consciência , Humanos , Distribuição Aleatória , Acidente Vascular Cerebral/terapia , Resultado do Tratamento
18.
Zhongguo Zhen Jiu ; 40(9): 953-6, 2020 Sep 12.
Artigo em Chinês | MEDLINE | ID: mdl-32959590

RESUMO

OBJECTIVE: To compare the clinical effect of lower extremity varicose veins between fire needling bloodletting and operation, and to explore the possible mechanism. METHODS: A total of 60 patients were randomized into an observation group and a control group, 30 cases in each one. In the control group,the operation was adopted. The fire needling bloodletting was applied in the observation group, twice a week for 4 weeks. Before and after treatment, the venous clinical severity score (VCSS) and venous disability score (VDS) were recorded, the hemorheological indexes [blood viscosity, plasma viscosity, hematocrit, fibrinogen and erythrocyte sedimentation rate (ESR)], immune inflammatory response indexes[serum C-reactive protein (CRP), tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6)], vascular endothelial cell function indexes [the number of circulatingendothelial cell (CEC), plasma endothelin (ET-1) and NO)] and apoptosis indexes (Bcl-2, Bax and Caspase-3) were detected in the two groups. RESULTS: Compared before treatment, the scores of VCSS and VDS, hemorheological indexes, immune inflammatory response indexes and levels of plasma NO after treatment were reduced in the two groups (P<0.05). The level of serum Bax after treatment was reduced in the observation group (P<0.05). The number of CEC and levels of plasma ET-1 after treatment were increased in the two groups (P<0.05). The levels of serum Bcl-2 and Caspase-3 after treatment were increased in the observation group (P<0.05). In the observation group, the scores of VCSS and VDS, hemorheological indexes,immune inflammatory response indexes, vascular endothelial cell function indexes and level of serum Bax after treatment were lower than the control group (P<0.05), and the levels of Bcl-2 and Caspase-3 were higher than the control group (P<0.05). CONCLUSION: Fire needling bloodletting could effectively treat lower extremity varicose veins, and the mechanism may be related to the improvement of hemorheology, downregulation of immune inflammatory response, improvement of vascular endothelial cell function and inhibition of apoptosis.


Assuntos
Terapia por Acupuntura , Sangria , Varizes , Humanos , Extremidade Inferior , Varizes/terapia , Procedimentos Cirúrgicos Vasculares
19.
Zhongguo Zhen Jiu ; 40(8): 845-8, 2020 Aug 12.
Artigo em Chinês | MEDLINE | ID: mdl-32869593

RESUMO

OBJECTIVE: To compare the curative effect between bloodletting at tip of ear with different amounts combined with western medication and western medication alone for early-stage stye. METHODS: A total of 108 patients with early-stage stye were randomly divided into a 50 µL group (36 cases, 4 cases dropped off), a 100 µL group (36 cases, 2 cases dropped off) and a western medication group (36 cases, 5 cases dropped off). The patients in the western medication group were treated with levofloxacin eye drops and levofloxacin hydrochloride eye gel. Based on the treatment of the western medication group, the patients in the 50 µL group were treated with 50 µL bloodletting (about 3 drops) at tip of ear while the patients in the 100 µL group were treated with 100 µL bloodletting (about 6 drops) at tip of ear; the bloodletting was given once a day for 3 days. After treatment, the changes of visual analogue scale (VAS) and clinical effect were observed, and the patients were followed up by telephone on the 8th day. RESULTS: After treatment, the VAS score in each group was reduced (P<0.01), and the score in the 50 µL group and 100 µL group was lower than that in the western medication group (P<0.05, P<0.01), and the score in the 100 µL group was lower than that in the 50 µL group (P<0.05). After treatment, the cured rate was 76.5% (26/34) in the 100 µL group, 71.9% (23/32) in the 50 µL group and 51.6% (16/31) in the western medication group, and there were no significant differences among three groups (P>0.05). One week after the onset of the disease, all the patients in the 50 µL group and 100 µL group were cured, and one patient in the western medication group was not cured, and treated with routine surgery. CONCLUSION: Based on the conventional western medication treatment, bloodletting at tip of ear can significantly reduce the pain of stye, and the effect of 100 µL bleeding is better than 50 µL.


Assuntos
Terapia por Acupuntura , Sangria , Terçol , Manejo da Dor , Pontos de Acupuntura , Terçol/complicações , Terçol/terapia , Humanos , Dor , Resultado do Tratamento
20.
Medicine (Baltimore) ; 99(32): e21555, 2020 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-32769896

RESUMO

BACKGROUND: This study evaluated the effectiveness and safety of bloodletting (BL) at ear-apex (EX-HN6) as an adjunctive therapy to eye drops for stye. METHODS: This study systematically searched electronic databases from inception to March 1, 2020 in PUBMED, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journals Full-text Database, and WanFang Database. All potential randomized controlled trials (RCTs) investigating the effectiveness and safety of BL at EX-HN6 as an adjunctive therapy to eye drops for stye were included in this study. Study quality of all included studies was assessed by Cochrane Risk of Bias Assessment Tool. RevMan 5.3 software was used for statistical analysis and meta-analysis performance. RESULTS: A total of 11 RCTs, involving 1718 subjects, were included in this study. Results showed that BL at EX-HN6 as an adjunctive therapy to eye drops was superior to the eye drops alone in enhancing total effectiveness rate (risk ratio [RR] 1.21, 95% confidence intervals [CIs] [1.11, 1.32], I = 79%), and total cure rate (RR 1.28, 95% CIs [1.14, 1.43], I = 69%). After removing two studies, results of subgroup analysis still showed significant improvements in total effectiveness rate (RR 1.13, 95% CIs [1.08, 1.18], I = 0%), and total cure rate (RR 1.16, 95% CIs [1.08, 1.24], I = 0%). No data of adverse reactions was reported in primary trials, thus, this study did not analyze adverse reactions of BL at EX-HN6 as an adjunctive therapy to eye drops for stye. CONCLUSION: BL at EX-HN6 as an adjunctive therapy to eye drops may benefit stye. However, high-quality RCTs addressing on this issue is still needed to warrant the findings of this study.


Assuntos
Sangria/métodos , Terçol/terapia , Soluções Oftálmicas/uso terapêutico , Terapia Combinada , Humanos , Resultado do Tratamento
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