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1.
Cell Host Microbe ; 30(7): 908-916, 2022 07 13.
Artigo em Inglês | MEDLINE | ID: mdl-35834962

RESUMO

The human gut virome, which is often referred to as the "dark matter" of the gut microbiome, remains understudied. A better understanding of the composition and variations of the gut virome across populations is critical for exploring its impact on diseases and health. A series of advances in the characterization of human gut virome have unveiled high genetic diversity and various functional potentials of gut viruses. Here, we summarize the recently available human gut virome databases and discuss their features, procedures, and challenges with the intention to provide a reference to researchers to use while choosing a profiling database. We also propose a "best practice" for cataloging the viral population.


Assuntos
Bacteriófagos , Microbioma Gastrointestinal , Vírus , Bacteriófagos/genética , Catalogação , Microbioma Gastrointestinal/genética , Humanos , Viroma/genética , Vírus/genética
2.
Plant Cell ; 32(1): 8-9, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31748329
3.
Plant Cell ; 32(1): 123-138, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31712406

RESUMO

The lack of resolution when studying the many different ubiquitin chain types found in eukaryotic cells has been a major hurdle to our understanding of their specific roles. We currently have very little insight into the cellular and physiological functions of Lys-63 (K63)-linked ubiquitin chains, although they are the second most abundant forms of ubiquitin in plant cells. To overcome this problem, we developed several large-scale approaches to characterize (1) the E2-E3 ubiquitination machinery driving K63-linked ubiquitin chain formation and (2) K63 polyubiquitination targets to provide a comprehensive picture of K63 polyubiquitin networks in Arabidopsis (Arabidopsis thaliana). Our work identified the ubiquitin-conjugating enzymes (E2s) UBC35/36 as the major drivers of K63 polyubiquitin chain formation and highlights the major role of these proteins in plant growth and development. Interactome approaches allowed us to identify many proteins that interact with the K63 polyubiquitination-dedicated E2s UBC35/36 and their cognate E2 variants, including more than a dozen E3 ligases and their putative targets. In parallel, we improved the in vivo detection of proteins decorated with K63-linked ubiquitin chains by sensor-based proteomics, yielding important insights into the roles of K63 polyubiquitination in plant cells. This work strongly increases our understanding of K63 polyubiquitination networks and functions in plants.


Assuntos
Genômica , Lisina/metabolismo , Células Vegetais/metabolismo , Poliubiquitina/metabolismo , Proteômica , Arabidopsis/metabolismo , Proteínas de Arabidopsis , Catalogação , Ubiquitina/metabolismo , Enzimas de Conjugação de Ubiquitina/metabolismo , Ubiquitina-Proteína Ligases/genética , Ubiquitinação
4.
São Paulo; BIREME/OPAS/OMS; dez. 2019. 19 p. tab.
Não convencional em Português | LILACS, Redbvs | ID: biblio-1026874

RESUMO

Tabela de conversão de dados para fins de interoperabilidade entre formato MARC21 e Metodologia LILACS para criação de registros bibliográficos


Assuntos
Catalogação/normas , LILACS/normas , Interoperabilidade da Informação em Saúde/normas
5.
J Med Libr Assoc ; 107(4): 560-565, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31607813

RESUMO

Background: After several years of storing a large number of historical medical books that had been weeded from the general collection, the University of New Mexico Health Sciences Library and Informatics Center developed a set of evaluation criteria to determine whether the material should be kept and included in the library catalog or discarded. The purpose of this article is to share lessons learned in evaluating and processing a historical medical book collection. The authors share how we determined review criteria as well as cataloging and processing procedures. Case Presentation: Best practices for evaluating, cataloging, and processing historical library material were determined through a literature search and then reviewed and adapted for application to this project. Eight hundred sixty-two titles were selected to add to the catalog and were added to a shelving location in our offsite storage facility. Conclusions: These materials are now discoverable in the library's catalog for library users who are interested in historical research, and the materials have been processed for easy retrieval as well as preservation purposes.


Assuntos
Catalogação/normas , Catálogos de Bibliotecas , Bibliotecas Médicas/organização & administração , Desenvolvimento de Coleções em Bibliotecas/normas , Acervo de Biblioteca/organização & administração , Humanos , New Mexico , Objetivos Organizacionais
6.
Am J Disaster Med ; 14(2): 89-95, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31637689

RESUMO

OBJECTIVE: Search and rescue after mass casualty incidents relies on robust data infrastructure. Federal Emergency Management Agency (FEMA's) Task Force 1 (TF1) trains its volunteers to locate and virtually tag scene incidents using a global positioning satellite (GPS) device programmed with markers for each incident (Iron Sights). The authors performed a pilot study comparing Iron Sights™ to a Wi-Fi-based real-time incident geolocation and virtual tagging dashboard (Panacea™) in creating a dynamic common operating picture. DESIGN: Twenty-nine stations were placed at a predefined scene incident, each featuring a set of varying waypoint markers using standard FEMA/TF1 nomenclature. Two volunteers performed the experiment for both the Iron Sights and Panacea systems, digitally tagging all station waypoints. SETTING: TF1 simulation training field. MAIN OUTCOME MEASURE(S): Metrics compared included GPS location precision, marker accuracy, and delay between scene sweep and common operational picture (COP) generation. RESULTS: Two hundred and sixty-one waypoints were digitally tagged after excluding three stations for missing data. The average GPS location difference for all waypoints between Iron Sights and Panacea was 3.65 m. Marker tagging accuracy between Iron Sights and Panacea was equivalent and not statistically different (78.8 percent vs 66.2 percent, respectively, p = 0.11). Waypoints were tagged in 26.59 minutes and 10.55 minutes on average, respectively. Time from scene sweep to virtual COP generation was 7.97 minutes for Iron Sights after complete scene sweep and 37 seconds for Panacea for each waypoint posting in real-time. CONCLUSIONS: Panacea generated the COP in real-time compared to a delay with Iron Sights while maintaining the same location precision and marker accuracy. This pilot trial successfully demonstrated the ability to provide real-time actionable intelligence to incident commanders during mass casualty search and rescue missions. Larger field trials are recommended to refine the system and broaden its capabilities.


Assuntos
Simulação por Computador , Planejamento em Desastres/métodos , Serviços Médicos de Emergência , Incidentes com Feridos em Massa , Catalogação , Humanos , Projetos Piloto
7.
Recurso educacional aberto em Espanhol | CVSP - Regional | ID: oer-3844

RESUMO

Al final de este guía, el usuario es capaz de: - Acceder el sistema FI-Admin para ingresar y editar registros de recursos educativos de un repositorio del nodo país del CVSP. - Reconocer los principales componentes y funciones del sistema FI-Admin, permitiendo describir, indizar, enlazar y relacionar los registros de recursos educativos.


Assuntos
Materiais de Ensino , Bases de Dados Bibliográficas , Bibliotecas Digitais , Catalogação , Indexação e Redação de Resumos , Gestão da Informação , Sistemas de Informação
8.
Autophagy ; 15(7): 1280-1295, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-30669929

RESUMO

Macroautophagy/autophagy is a complex self-degradative mechanism responsible for clearance of non functional organelles and proteins. A range of factors influences the autophagic process, and disruptions in autophagy-related mechanisms lead to disease states, and further exacerbation of disease. Despite in-depth research into autophagy and its role in pathophysiological processes, the resources available to use it for therapeutic purposes are currently lacking. Herein we report the Autophagy Small Molecule Database (AutophagySMDB; http://www.autophagysmdb.org/ ) of small molecules and their cognate protein targets that modulate autophagy. Presently, AutophagySMDB enlists ~10,000 small molecules which regulate 71 target proteins. All entries are comprised of information such as EC50 (half maximal effective concentration), IC50 (half maximal inhibitory concentration), Kd (dissociation constant) and Ki (inhibition constant), IUPAC name, canonical SMILE, structure, molecular weight, QSAR (quantitative structure activity relationship) properties such as hydrogen donor and acceptor count, aromatic rings and XlogP. AutophagySMDB is an exhaustive, cross-platform, manually curated database, where either the cognate targets for small molecule or small molecules for a target can be searched. This database is provided with different search options including text search, advanced search and structure search. Various computational tools such as tree tool, cataloging tools, and clustering tools have also been implemented for advanced analysis. Data and the tools provided in this database helps to identify common or unique scaffolds for designing novel drugs or to improve the existing ones for autophagy small molecule therapeutics. The approach to multitarget drug discovery by identifying common scaffolds has been illustrated with experimental validation. Abbreviations: AMPK: AMP-activated protein kinase; ATG: autophagy related; AutophagySMDB: autophagy small molecule database; BCL2: BCL2, apoptosis regulator; BECN1: beclin 1; CAPN: calpain; MTOR: mechanistic target of rapamycin kinase; PPARG: peroxisome proliferator activated receptor gamma; SMILES: simplified molecular input line entry system; SQSTM1: sequestosome 1; STAT3: signal transducer and activator of transcription.


Assuntos
Proteínas Relacionadas à Autofagia/efeitos dos fármacos , Autofagia/efeitos dos fármacos , Bases de Dados de Produtos Farmacêuticos , Bibliotecas de Moléculas Pequenas/química , Autofagia/genética , Proteínas Relacionadas à Autofagia/antagonistas & inibidores , Catalogação , Humanos , Concentração Inibidora 50 , Ferramenta de Busca , Bibliotecas de Moléculas Pequenas/farmacologia , Software
10.
Cell Syst ; 6(1): 13-24, 2018 01 24.
Artigo em Inglês | MEDLINE | ID: mdl-29199020

RESUMO

The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program that catalogs how human cells globally respond to chemical, genetic, and disease perturbations. Resources generated by LINCS include experimental and computational methods, visualization tools, molecular and imaging data, and signatures. By assembling an integrated picture of the range of responses of human cells exposed to many perturbations, the LINCS program aims to better understand human disease and to advance the development of new therapies. Perturbations under study include drugs, genetic perturbations, tissue micro-environments, antibodies, and disease-causing mutations. Responses to perturbations are measured by transcript profiling, mass spectrometry, cell imaging, and biochemical methods, among other assays. The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders. This Perspective describes LINCS technologies, datasets, tools, and approaches to data accessibility and reusability.


Assuntos
Catalogação/métodos , Biologia de Sistemas/métodos , Biologia Computacional/métodos , Bases de Dados de Compostos Químicos/normas , Perfilação da Expressão Gênica/métodos , Biblioteca Gênica , Humanos , Armazenamento e Recuperação da Informação/métodos , Programas Nacionais de Saúde , National Institutes of Health (U.S.)/normas , Transcriptoma , Estados Unidos
12.
Zootaxa ; 4122(1): 239-45, 2016 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-27395269

RESUMO

An updated catalogue of the family Scatopsidae in Colombia is presented. Seven species of six genera have being recorded for the country, but four of these species are still undescribed. The Ectaetiinae genus Ectaetia, the Psectrosciarinae genera Anapausis and Psectrosciara, and at least the Scatopsinae genera Scatopse, Efcookella, and Abrhexoza are expected to be present in the fauna of the family in Colombia.


Assuntos
Abreviaturas como Assunto , Catalogação , Dípteros/classificação , Distribuição Animal , Animais , Colômbia , Dípteros/anatomia & histologia , Feminino , Masculino
13.
Zootaxa ; 4122(1): 246-8, 2016 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-27395270

RESUMO

The family Rhagionidae is one of the oldest Brachyeran lineages. Its monophyly is still uncertain. There are four rhagionid genera distributed in Neotropical Region but only three species of Chrysopilus are found in Colombia.


Assuntos
Abreviaturas como Assunto , Catalogação , Dípteros/classificação , Distribuição Animal , Animais , Colômbia , Dípteros/anatomia & histologia , Feminino
14.
Zootaxa ; 4122(1): 249-301, 2016 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-27395271

RESUMO

This catalogue presents 256 species distributed in 32 genera, six tribes and three subfamilies recorded to Colombia. For each species we present the available geographical information and most important references.


Assuntos
Abreviaturas como Assunto , Catalogação , Dípteros/classificação , Distribuição Animal , Animais , Colômbia , Dípteros/anatomia & histologia , Feminino , Masculino
15.
Zootaxa ; 4122(1): 302-5, 2016 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-27395272

RESUMO

This family is recorded for the first time to Colombia, with only one undescribed species of genus Rachicerus.


Assuntos
Abreviaturas como Assunto , Catalogação , Dípteros/classificação , Distribuição Animal , Animais , Colômbia , Dípteros/anatomia & histologia , Feminino , Masculino
16.
Zootaxa ; 4122(1): 306-11, 2016 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-27395273

RESUMO

This catalogue features 11 species distributed in 2 genera recorded to Colombia. Three species of Pantophthalmus are recorded for the first time to the country.


Assuntos
Abreviaturas como Assunto , Catalogação , Dípteros/classificação , Distribuição Animal , Animais , Colômbia , Dípteros/anatomia & histologia , Feminino , Masculino
17.
Zootaxa ; 4122(1): 312-41, 2016 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-27395274

RESUMO

The family Stratiomyidae has more than 2,800 described species, of which 1001 species belongs to the Neotropics. This catalog for Colombia presents 87 species distributed in 32 genera, and ten subfamilies. Merosargus gracilis and the genus Microchrysa, with a single species M. bicolor are recorded for the first time to Colombia. The fauna is very expressive but still poorly known, representing nearly one tenth of the Neotropical diversity of the family in numbers of species, and one fifth of generic diversity.


Assuntos
Abreviaturas como Assunto , Catalogação , Dípteros/classificação , Distribuição Animal , Animais , Biodiversidade , Colômbia , Dípteros/anatomia & histologia , Feminino , Masculino
18.
Zootaxa ; 4122(1): 342-5, 2016 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-27395275

RESUMO

This family is poor known in Colombia with only two known species of two genera, Solva tuberculata and Arthropeina colombiana.


Assuntos
Abreviaturas como Assunto , Catalogação , Dípteros/classificação , Distribuição Animal , Animais , Biodiversidade , Colômbia , Dípteros/anatomia & histologia , Feminino , Masculino
19.
Zootaxa ; 4122(1): 346-9, 2016 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-27395276

RESUMO

A catalog of the Acroceridae from Colombia is provided. Five species and five genera are recorded for the country, including one undescribed Ocnaea species.


Assuntos
Abreviaturas como Assunto , Catalogação , Dípteros/classificação , Distribuição Animal , Animais , Colômbia , Dípteros/anatomia & histologia , Feminino , Masculino
20.
Zootaxa ; 4122(1): 350-2, 2016 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-27395277

RESUMO

Nemestrinidae (Diptera, Nemestrinoidea) are a relatively rare group of flies, and the knowledge on the Colombian fauna is still incipient. According to the available literature, only one species is recorded to this country, Hyrmophlaeba magdalena Bernardi, 1977.


Assuntos
Abreviaturas como Assunto , Catalogação , Dípteros/classificação , Distribuição Animal , Animais , Colômbia , Dípteros/anatomia & histologia , Feminino , Masculino
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