Evaluation of marginal and internal fit of lithium disilicate and zirconia all-ceramic CAD-CAM crowns using digital impressions: A systematic review.

PURPOSE: A range of materials for single-tooth computer-aided design and computer-aided manufacturing (CAD-CAM) restorations have been introduced that may affect CAM accuracy. This study aimed to review articles evaluating marginal and internal fit of lithium disilicate (LD) and zirconia (Z) crowns fabricated by CAD-CAM systems using intraoral optical scanners (IOS). MATERIALS AND METHODS: Under the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA), a systematic review was performed along with an electronic article search in the Medline/Pubmed database. The articles were limited to those in the English language that were published within the past ten years. RESULTS: The initial search resulted in 50 articles and of those, a total of 18 articles were selected for full-text review following abstract evaluation. Eight articles that did not meet the inclusion criteria were excluded and the remaining ten articles, which provided internal and marginal gap values, were used in this review. For LD crowns, marginal gap values ranged between 45µm and 190.2µm. For Z crowns, the values varied between 39µm and 126.4µm. For LD crowns, the internal gap values were between 57.8µm and 475.4µm, and for Z crowns, the values were between 79µm and 205.8µm. CONCLUSION: The outcome of this review suggests that clinically acceptable marginal and internal fit can be attained with LD and Z all-ceramic CAD-CAM crowns using digital impressions. Additionally, it has been found that LD and Z ceramics provide similar marginal gap values, but LD material provides better internal fit than Z.

Failure behavior of zirconia crowns subjected to air abrasion with different particle sizes.

This study aimed to investigate the failure behavior of 3 mol.% yttria-stabilized tetragonal zirconia polycrystal (3Y-TZP) prosthetic crowns air-abraded with aluminum oxide (AO) particles of different sizes. Ninety ceramic premolar crowns were produced with 3Y-TZP frameworks veneered with porcelain. Crowns were randomly divided into three groups, according to the size of the air abrasion AO particles (n = 30): (GC) untreated (control); (G53) 53 µm; (G125) 125 µm. Air abrasion was performed with 0.25 mpa pressure, 10-mm distance, for 10 s. Crowns were adhesively cemented to dentin analog abutments. Specimens were loaded in compression to failure, in 37oC distilled water, using a universal testing machine (n = 30). Fractographic analysis was performed using a stereomicroscope and SEM. The roughness of the crown's inner surface was evaluated using an optical profilometer (n = 10). Fracture load data were statistically analyzed with Weibull analysis and roughness data with Kruskal-Wallis (α = 0.05). GC had the lowest characteristic fracture load (L0), while G53 and G125 had higher and statistically similar L0 values. The Weibull modulus (m) was similar among groups. The failure modes observed were catastrophic failure and porcelain chipping. There were no differences between the roughness parameters for the experimental groups (p > 0.05). The size of the AO particles did not affect the fracture load and failure mode of 3Y-TZP crowns. Air abrasion with 53 µm and 125 µm particles resulted in a higher fracture load of ceramic crowns than the untreated group while maintaining their reliability and surface characteristics.

Fatigue-life and stress distribution of a glass-ceramic under different loading conditions.

This study aimed to evaluate the effect of different loading conditions on the mechanical behavior and stress distribution of a leucite-reinforced glass-ceramic. Plate-shaped ceramic specimens were obtained from leucite-reinforced glass-ceramic (1.5 × 8.4 × 8.3 mm) and adhesively cemented to a dentin analog substrate. Monotonic and cyclic contact fatigue tests were performed to simulate sphere-to-flat contact, using a 6 mm diameter spherical piston; and flat-to-flat contact, using a 3 mm diameter flat piston. For the monotonic test (n=20), a gradual compressive load (0.5 mm/min) was applied to the specimen using a universal testing machine. Failure load data were analyzed with Weibull statistics. The cyclic contact fatigue test was performed using protocols (load and a number of cycles) defined by the boundary technique (n=30). Fatigue data were analyzed using an inverse power law relationship and Weibull-lifetime distribution. The stress distribution was investigated using Finite Element Analysis (FEA). The monotonic and the fatigue Weibull modulus were similar among the two contact conditions. In fatigue, the slow crack growth exponent was greater for sphere-to-flat contact, which indicates that the load level had a greater effect on the specimen's probability of failure. In conclusion, FEA showed different stress distribution for the tested loading conditions. The stress distribution and probability of fatigue failure of specimens tested in sphere-to-flat contact showed greater dependency to load level.

The influence of different storage media on Vickers hardness and surface roughness of CAD/CAM resin composites.

INTRODUCTION: This study examined Vickers hardness as well as surface characteristics of different computer-aided design/computer-aided manufacturing (CAD/CAM) resin composites prior to and after storage in various media. MATERIALS AND METHODS: CAD/CAM resin composite blocks (Grandio Blocs (GB), Lava Ultimate (LU), Brilliant Crios (BC), Cerasmart (GC), Shofu Block HC (SB), Tetric CAD (TC), Luxacam Composite (LC); incl. different translucency variants) were prepared, polished and surface free energy was determined. The specimens were divided into four groups: dry conditions for 24 h (25 °C), demineralized water (37 °C), Pepsi Cola (37 °C) and 75% ethanol (37 °C). After seven and 28 days of storage, Vickers hardness was determined. Surface roughness was measured after the entire storage period. RESULTS AND DISCUSSION: Vickers hardness was in the range of about 150 HV for GB, around 115 HV for LU, and 80-100 HV for BC, GC, SB, TC and LC. Only minor differences (total: 50.2 (6.4)-56.2 (3.2) mN/m) in surface free energy could be detected. No relationship was observed between surface free energy and filler content. However, a correlation between filler content and Vickers hardness was evident. Artificial aging caused a decrease of Vickers hardness (up to -40 HV or 35%) depending on storage media, duration and material. The changes in surface texture after immersion in different media were below a value of ΔSa = 0.015 µm. CONCLUSION: Artificial aging of CAD/CAM resin composites leads to a significant decrease of Vickers hardness for most materials, while only small changes in surface roughness were identified.

How does the occlusal contact region influence the mechanical fatigue performance and fracture region of monolithic lithium disilicate ceramic crowns?

OBJECTIVE: To characterize the effect of the occlusal contact region on the mechanical fatigue performance and on the fracture region of monolithic lithium disilicate ceramic crowns. MATERIALS AND METHODS: Monolithic lithium disilicate ceramic crowns were machined in a CAD/CAM system and adhesively luted onto glass-fiber reinforced epoxy resin preparations with resin cement. The crowns were divided into three groups (n = 16) according to load application region (cusp tip: restricted to cusp tips; cusp plane: restricted to cuspal inclined plane; or mixed: associating tip cusp and cuspal inclined plane). The specimens were submitted to a cyclic fatigue test (initial load: 200 N; step-size: 100 N; cycles/step: 20,000; loading frequency: 20 Hz; load applicator: 6 mm or 40 mm diameter stainless steel) until observing cracks (1st outcome) and fracture (2nd outcome). The data were analyzed by the Kaplan-Meier + Mantel-Cox post-hoc tests for both outcomes (cracks and fracture). Finite element analysis (FEA), occlusal contact region, contact radii measurements, and fractographic analyzes were performed. RESULTS: The mixed group presented worse fatigue mechanical behavior (550 N / 85.000 cycles) compared to the cuspal inclined plane group (656 N / 111,250 cycles) (p < 0.05) for the first crack outcome, while the cusp tip group was similar to both groups (588 N / 97,500 cycles) (p > 0.05). The mixed group had the worst fatigue behavior (1413 N / 253,029 cycles) in relation to the other groups (Cusp tip: 1644 N / 293,312 cycles; Cuspal inclined plane: 1631 N / 295,174 cycles) considering the crown fracture outcome (p < 0.05). FEA showed higher tensile stress concentration areas just below the load application region. In addition, loading on the cuspal inclined plane induced a higher tensile stress concentration in the groove region. The most prevalent type of crown fracture was the wall fracture. Groove fracture was observed in 50% of the loading specimens exclusively on the cuspal inclined plane. CONCLUSION: Load application on distinct occlusal contact regions affects the stress distribution pattern and consequently the mechanical fatigue performance and fracture region of the monolithic lithium disilicate ceramic crowns. A combination of loading at distinct regions is recommended to promote better evaluation of the fatigue behavior of a restored set.

Impact of various clinical factors on the final color of ceramic/glass-polymer based CAD-CAM materials.

PURPOSE: To evaluate the effect of material type, material thickness and cement shade on the final color of two different ceramic/glass-polymer-based CAD-CAM blocks over colored abutments. METHODS: Tested blocks (Vita Enamic-VE and Cerasmart-Cs) were cut in three different thicknesses (1, 1.5 and 2 mm), and cemented on two different shaded (B1 and C3) resin discs with three shades (A2-Universal, W-White, T-Translucent) of a self-adhesive resin cement. An additional 10 specimens were prepared for control (n= 370). 36 subgroups were formed to simulate different clinical conditions (n= 10). The final color difference (ΔE00) was recorded as the difference between material-cement-resin composite assembly and control specimens on a black background according to the CIEΔE 2000 color difference formula. Clinical perceptibility (0.80) and acceptability thresholds (1.80) were used to evaluate the results. Data were analyzed using the Kruskal-Wallis and the Mann-Whitney U non-parametric tests at P< 0.05 significance level. RESULTS: ΔE00 results were influenced by the polymer-based CAD-CAM material type, material thickness, and cement shade (P< 0.05) over both abutment shades. VE exhibited lower ΔE00 values than Cs over B1 and C3 shaded abutments (for each abutment P< 0.001). Specimens of 1 mm thickness exhibited significantly higher ΔE00 than the 2 mm or 1.5 mm specimens (P< 0.001), and W cement shade demonstrated higher ΔE00 than T or A2 shades (P< 0.001) over both shaded abutments. CLINICAL SIGNIFICANCE: The final color of the polymer-based CAD-CAM restoration can be improved by the suitable combination of material/material thickness/cement shade to achieve the desired esthetic outcomes within clinically acceptable limits. Regardless of the type of polymer-based CAD-CAM material chosen, at least 1.5 mm restoration thickness with the use of Translucent or A2 cement shade is recommended for masking whitened or darkened shaded abutment teeth in clinical practice.

Comparison of the light transmission of new generation monolithic zirconia materials and lithium disilicate.

PURPOSE: To compare the effects of different thicknesses of ceramic veneering on the light transmission of various monolithic zirconia and lithium disilicate materials used in esthetic restorations. METHODS: Zirconia (i.e., Katana UT, Katana HT, Prozir Diamond, Prozir HT, and Zenostar MO) and lithium disilicate specimens (i.e., Emax HT and Emax MO) were prepared at thicknesses of 0.5 mm, 0.8 mm, and 1.2 mm. Additionally, 0.8 mm-thick specimens and 0.3 mm-thick ceramic veneer were prepared for veneering groups. The total transmittance of light values were measured using a spectrophotometer. The light transmission values were analyzed using the Kruskal-Wallis and the post-hoc Dunnett tests (α= 0.05). RESULTS: The Emax HT group defined significant differences from all groups (P< 0.05) at all thicknesses. The mean total transmittance of light ranged from 5.53% to 19.55%. There was no significant difference between the Katana UT and Prozir Diamond groups at the 0.5 mm, 0.8 mm, and 1.2 mm thicknesses (P> 0.05). CLINICAL SIGNIFICANCE: The results of this study showed no significant effects of veneering ceramic on the light transmittance of the specimens at a thickness of 0.8 mm. Novel monolithic zirconia materials may be preferred over porcelain veneering in 0.8 mm-thick restorations, as the esthetic appearance of the restorations would not change.

Effect of Membrane Pore Size on Membrane Fouling of Corundum Ceramic Membrane in MBR.

Ceramic membrane has emerged as a promising material to address the membrane fouling issue in membrane bioreactors (MBR). In order to optimize the structural property of ceramic membrane, four corundum ceramic membranes with the mean pore size of 0.50, 0.63, 0.80, and 1.02 µm were prepared, which were designated as C5, C7, C13, and C20, respectively. Long-term MBR experiments showed that the C7 membrane with medium pore size experienced the lowest trans-membrane pressure development rate. Both the decrease and increase of membrane pore size would lead to more severe membrane fouling in the MBR. It was also interesting that with the increase of membrane pore size, the relative proportion of cake layer resistance in total fouling resistance was gradually increased. The content of dissolved organic foulants (i.e., protein, polysaccharide and DOC) on the surface of C7 was quantified as the lowest among the different ceramic membranes. Microbial community analysis also revealed the C7 had a lower relative abundance of membrane fouling associated bacteria in its cake layer. The results clearly demonstrated that ceramic membrane fouling in MBR could be effectively alleviated through optimizing the membrane pore size, which was a key structural factor for preparation of ceramic membrane.

[Study on the correlation between ceramic and chronic obstructive pulmonary disease in Foshan City].

Objective: To study the correlation between ceramic and chronic obstructive pulmonary disease (COPD), and explore its related risk factors. Methods: In January 2021, five representative ceramic enterprises were selected from Chancheng District, Nanhai District, Gaoming District and Sanshui District of Foshan City. The ceramic workers who came to Chancheng Hospital of Foshan First People's Hospital for physical examination from January to October 2021 were selected as the research objects, and 525 people were included. Conduct questionnaire survey and pulmonary function test. Logistic regresion was performed to analyze the influencing facters of COPD among ceramic workers. Results: The subjects were (38.51±1.25) years old, 328 males and 197 females, and the detection rate of COPD was 9.52% (50/525). The incidence of respiratory symptoms such as dyspnea, chronic cough, wheezing and chest tightness, the detection rates of abnormal lung age, abnormal lung function and COPD in males were higher than those in females (P<0.05). The logistic regression analysis showed that male, age, working years, smoking status and family history of COPD were the risk factors for COPD among ceramic workers (P<0.05) . Conclusion: The ceramic workers are the high risk population of COPD. We should do a good job in health education, and do a regular physical examination to find the changes of lung function in time, and prevent the occurrence of COPD as soon as possible.

"Well" off in animals: A taphonomic history of faunal resources and refuse from a well feature at Petsas House, Mycenae (Greece).

At the renowned archaeological site of Mycenae, striking depictions of animals in ancient art and architecture, such as the 'Lion Gate', reflect the great power of elite residents in the Late Bronze Age. To better understand how social complexity relates to human-animal interactions at Mycenae, more research is needed on the animals who actually lived there. In a first for the archaeological site of Mycenae, we utilized a contextual taphonomic approach and statistical analysis to study a faunal assemblage, focusing on a massive deposit recovered from a well feature located in Room Π of Petsas House. Petsas House was an industrial-residential complex at Mycenae used at least in part by ceramic artisans at the time of its destruction in the Late Helladic IIIA2 period. Intra-contextual analysis of the animal remains detected sub-assemblages with variable histories of animal use and deposition. The results revealed multiple disposal events and possible dog interments. Most of the refuse in the well likely originated from rubbish piles in the surrounding rooms and periphery that were cleaned after a destructive earthquake. Together, the faunal evidence yielded a more nuanced, possibly seasonal picture of animal access than previously available at this important political center. The results provide new insights into the diverse and resilient resource provisioning strategies available to extra-palatial residents of Mycenae, especially those who participated in craft production and trade networks at the height of the palatial period.

Crossover trial of the effects of a far-infrared heater that heats the feet with ceramic balls on autonomic nervous activity and mood states.

INTRODUCTION: The accumulation of fatigue and stress creates problems, including reductions in quality of life and productivity. OBJECTIVES: To investigate the effects of a far-infrared heater that heats the feet with ceramic balls on autonomic nervous activity and mood states. METHODS: This study was performed as a crossover trial. Participants comprised 20 women. On different days, each participant underwent 15 min of foot warming with the far-infrared heater (far-infrared group) or remained seated for 15 min (control group). Autonomic nervous activity (low-frequency component/high-frequency component, high-frequency) and mood states scales (Profile of Mood States Second Edition and Two-Dimensional Mood Scale for Self-monitoring and Self-regulation of Momentary Mood States) during the study intervention were measured and compared between groups. RESULTS: Low-frequency/high-frequency was significantly higher in the control group 10 min after the start of intervention than at baseline (P = .033). Low-frequency/high-frequency was significantly lower in the far-infrared group than in the control group at 5 min (P = .027), 10 min (P = .011), and 15 min (P = .015). High-frequency was significantly higher in the far-infrared group at 5 min (P = .008), 10 min (P = .004), and 15 min (P = .015) than at baseline. High-frequency 5 min after the start of intervention was significantly higher in the far-infrared group than in the control group (P = .033). POMS2 scores improved significantly more in the far-infrared group than in the control group, including in fatigue-inertia (P = .019), tension-anxiety (P = .025), and total mood disturbance (P = .019). Finally, the far-infrared group showed greater improvements in Two-Dimensional Mood Scale-Short Term scores such as stability (P = .002) and pleasure (P = .013). CONCLUSION: Using the far-infrared heater to heat the feet with ceramic balls stabilized and improved mood, reduced Fatigue-Inertia and Tension-Anxiety, and alleviated total mood disturbance. Parasympathetic nervous system activation was observed from 5 min after the start of heating, suggesting that short-duration heat stimulation of the feet is effective.

Additive Manufacturing of Bioceramic Implants for Restoration Bone Engineering: Technologies, Advances, and Future Perspectives.

Treating bone defects is highly challenging because they do not heal on their own inside the patients, so implants are needed to assist in the reconstruction of the bone. Bioceramic implants based on additive manufacturing (AM) are currently emerging as promising treatment options for restoration bone engineering. On the one hand, additively manufactured bioceramic implants have excellent mechanical properties and biocompatibility, which are suitable for bone regeneration. On the other hand, the designable structure and adjustable pores of additively manufactured bioceramic implants allow them to promote suitable cell growth and tissue climbing. Herein, this review unfolds to introduce several frequently employed AM technologies for bioceramic implants. After that, advances in commonly used additively manufactured bioceramic implants, including bioinert ceramic implants, bioactive ceramic implants, and bioceramic/organic composite implants, are categorized and summarized. Finally, the future perspectives of additively manufactured bioceramic implants, in terms of mechanical performance improvement, innovative structural design, biological property enhancement, and other functionalization approaches, are proposed and forecasted. This review is believed to provide some fundamental understanding and cutting-edge knowledge for the additive manufacturing of bioceramic implants for restoration bone engineering.

Four-point flexural strength and microtensile bond strength of digitally and conventionally veneered zirconia.

This study intended to evaluate the effect of digital veneering on four-point flexural strength (FS) and microtensile bond strength (µTBS) of veneered zirconia. Two different zirconia blocks, a lithium disilicate and a feldspathic ceramic block, and two different layering ceramics were used. IPS e.max Zir CAD (ZC) and Vita In-Ceram YZ (YZ) with yttria stabilized tetragonal zirconia polycrystals (3Y-TZP) were used as substructures. IPS e.max CAD (LD), Vita Mark II (VMII), IPS e.max Ceram (EC) and Vita VM9 (VM9) were used for veneering. Resin cement and fusion ceramic were placed between veneer and zirconia substructure for digital veneering. A total of one hundred and fifty specimens in five groups (n = 30) were prepared for FS and tested in universal machine at 1.0 mm/min. One hundred specimens in five groups (n = 20) were obtained for the µTBS and tested at 1.0 mm/min. Statistical analysis was made by one way ANOVA and Tukey HSD. Conventional veneering showed statistically significant FS. ZC veneered with EC had the highest mean FS and the lowest was obtained in groups veneered through resin cement. YZ layered with VM9 had the highest mean µTBS. ZC veneered through fusion ceramic and YZ veneered through resin cement showed significantly lower and similar µTBS.

Fabrication and Properties of Biodegradable Akermanite-Reinforced Fe35Mn Alloys for Temporary Orthopedic Implant Applications.

As a representative of the biodegradable iron (Fe)-manganese (Mn) alloys, Fe35Mn has been investigated as a promising biodegradable metal biomaterial for orthopedic applications. However, its slow degradation rate, though better than pure Fe, and poor bioactivity are concerns that retard its clinical applications. Akermanite (Ca2MgSi2O7, Ake) is a silicate-based bioceramic, showing desirable degradability and bioactivity for bone repair. In the present work, Fe35Mn/Ake composites were prepared via a powder metallurgy route. The effect of different contents of Ake (0, 10, 30, 50 vol %) on the microstructure, mechanical properties, degradation, and biocompatibility of the composites was investigated. The ceramic phases were found to be evenly distributed in the metal matrix. The Ake reacted with Fe35Mn and generated CaFeSiO4 during sintering. The addition of Ake increased the relative density of pure Fe35Mn from ∼90 to ∼94-97%. The compressive yield strength (CYS) and elastic modulus (Ec) increased with increasing Ake, with Fe35Mn/50Ake exhibiting the highest CYS of ∼403 MPa and Ec of ∼18 GPa. However, the ductility decreased at higher Ake concentrations (30 and 50%). Microhardness also showed an increasing trend with the addition of Ake. Electrochemical measurements indicated that higher concentrations of Ake (30 and 50%) could potentially increase the corrosion rate of Fe35Mn from ∼0.25 to ∼0.39 mm/year. However, all of the compositions tested did not show measurable weight loss after immersion in simulated body fluid (SBF) for 4 weeks, attributed to the use of prealloyed raw material, high sintered density of the fabricated composites, and the formation of a dense Ca-, P-, and O-rich layer on the surface. Human osteoblasts on Fe35Mn/Ake composites showed increasing viability with increasing Ake content, indicating improved in vitro biocompatibility. These preliminary results suggest that Fe35Mn/Ake can be a potential material for biodegradable bone implant applications, particularly Fe35Mn/30Ake, if the slow corrosion of the composite can be addressed.

Does low-intensity pulsed ultrasound accelerate phasic calcium phosphate ceramic-induced bone formation?

PURPOSE: Low-intensity pulsed ultrasound (LIPUS) has been used to stimulate the healing of the fresh fracture, delayed union, and non-union in both animal and clinical studies. Besides, biphasic calcium phosphate ceramic (BCP) is a promising biomaterial for bone repair as it shows favorable biocompatibility, osteoinduction, and osteoconduction. However, scarcity is known about the combined effect of LIPUS and BCP on bone formation. METHODS: The combined effect of LIPUS and BCP was studied in a beagle model. Twelve dogs were used. BCP granules without any additions were implanted into bilateral erector spinae muscles. One side is the BCP group, while the counterlateral side is LIPUS + BCP group. Histological and histomorphometric analyses, and quantitative real-time polymerase chain reaction were evaluated. RESULTS: Compared with BCP alone, the LIPUS + BCP showed no advantages in early bone formation. Furthermore, the Notch signaling pathway-related mRNA has no significant difference between the two groups. CONCLUSIONS: The preliminary results showed that the BCP, which has intrinsic osteoinduction nature, was an effective and promising material. However, LIPUS has no enhanced effect in BCP induced ectopic bone formation. Furthermore, LIPUS has no effect on the Notch signaling pathway. Whether costly LIPUS could be used in combination with BCP should be a rethink.

Specific Aptamer Functionalization of Dense Ceramic by Click Chemistry Towards Circulating Tumor Cells Apheresis.

BACKGROUND/AIM: Circulating tumor cells (CTC) are tumor cells which can be disseminated at distance of the primary tumor and form metastatic niche. Moreover, their quantity is an important parameter which can induce cluster metastasis. A solution, can be the creation of a system that allow the capture and elimination from the blood of patients by using the medical device developed which is an inert bioceramic functionalized by aptamer target to CTC. MATERIALS AND METHODS: Herein we develop chemical reactions to bind a modified MUC1 specific DNA aptamer on an alumina (Al2O3) dense ceramic surface. In fact, MUC1 biomarker is very present on the surface of tumor cells. RESULTS: The specific developed chemical reactions led to the covalent binding of the aptamer while preserving its biological characteristics. CONCLUSION: This functionalization of dense alumina would allow the potential capture of circulating tumor cells.

3D porous bioceramic based boron-doped hydroxyapatite/baghdadite composite scaffolds for bone tissue engineering.

Making composite scaffolds is one of the well-known methods to improve the properties of scaffolds used in bone tissue engineering. In this study, novel ceramic-based 3D porous composite scaffolds were successfully prepared using boron-doped hydroxyapatite, as the primary component, and baghdadite, as the secondary component. The effects of making composites on the properties of boron-doped hydroxyapatite-based scaffolds were investigated in terms of physicochemical, mechanical, and biological properties. The incorporation of baghdadite contributed to making more porous scaffolds (over 40%) with larger surface area and micropore volumes. The produced composite scaffolds almost solved the low degradation problem of boron-doped hydroxyapatite through the exhibition of higher biodegradation rates, which matched the degradation rate appropriate for the gradual transfer of loads from implants to newly formed bone tissues. Besides higher bioactivity, enhanced cell proliferation, as well as higher osteogenic differentiation (in scaffolds with baghdadite weight greater than 10%), were observed in composite scaffolds due to both physical and chemical modifications that occurred in composite scaffolds. Although our composite scaffolds were slightly weaker than boron-doped hydroxyapatite, their compressive strengths were higher than almost all composite scaffolds made by baghdadite incorporation in the literature. In fact, boron-doped hydroxyapatite provided a base for baghdadite to show mechanical strength suitable for cancellous bone defect treatments. Eventually, our novel composite scaffolds converged the advantages of both components to satisfy the various requirements needed for bone tissue engineering applications and take us one step forward on the road to fabricating an ideal scaffold.

Fatigue performance analysis of strength-graded zirconia polycrystals for monolithic three-unit implant-supported prostheses.

The aim of this study was to evaluate the fatigue behavior of strength-graded zirconia polycrystals used as monolithic three-unit implant-supported prosthesis; complementarily, crystalline phase and micromorphology were also assessed. Fixed prostheses with 3 elements supported by 2 implants were confectioned, as follows: Group 3Y/5Y - monolithic structures of a graded 3Y-TZP/5Y-TZP zirconia (IPS e.max® ZirCAD PRIME); Group 4Y/5Y - monolithic structures of a graded 4Y-TZP/5Y-TZP zirconia (IPS e.max® ZirCAD MT Multi); Group Bilayer - framework of a 3Y-TZP zirconia (Zenostar T) veneered with porcelain (IPS e.max Ceram). The samples were tested for fatigue performance with step-stress analysis. The fatigue failure load (FFL), the number of cycles required until failure (CFF), and the survival rates in each cycle were recorded. The Weibull module was calculated and the fractography analyzed. The crystalline structural content via Micro-Raman spectroscopy and the crystalline grain size via Scanning Electron microscopy were also assessed for graded structures. Group 3Y/5Y showed the highest FFL, CFF, probability of survival, and reliability (based on Weibull modulus). Group 4Y/5Y showed significantly superior FFL and probability of survival than group bilayer. Fractographic analysis revealed catastrophic flaws in the monolithic structure and cohesive fracture of porcelain in bilayer prostheses, all originating from the occlusal contact point. The graded zirconia presented small grain size (≤0.61 µm), with the smallest values at the cervical region. The main composition of graded zirconia was of grains at tetragonal phase. The strength-graded monolithic zirconia, especially the 3Y-TZP/5Y-TZP, showed to be promising for use as monolithic three-unit implant-supported prosthesis.

Improving detection of fMRI activation at 1.5 T using high permittivity ceramics.

In this work, we propose an application of high permittivity materials (HPMs) to improve functional magnetic resonance imaging (fMRI) at 1.5 T, increasing the receive (Rx) sensitivity of a commercial multi-channel head coil. To evaluate the transmit efficiency, specific absorption rate (SAR), and the signal-to-noise ratio (SNR) changes introduced by the HPMs with relative permittivity of 4500, we considered the following configurations in simulation: a whole-body birdcage coil and an Rx-only multi-channel head coil with and without the HPM blocks in the presence of a homogeneous head phantom or a human body model. Experimental studies were also performed with a phantom and with volunteers. Seven healthy volunteers enrolled in a prospective study of fMRI activation in the motor cortex with and without HPMs. fMRI data were analyzed using group-level paired T-tests between acquisitions with and without HPM blocks. Both electromagnetic simulations and experimental measurements showed ∼25% improvement in the Rx sensitivity of a commercial head coil in the areas of interest when HPM blocks were placed in close proximity. It increased the detected motor cortex fMRI activation volume by an average of 56%, thus resulting in more sensitive functional imaging at 1.5 T.

Effects of 16% Carbamide Peroxide on Optical Properties of Thermally Aged Monolithic CAD-CAM Glass Ceramics with Different Surface Treatments.

This study aimed to investigate the effects of 16% carbamide peroxide (CP) on the relative translucency parameter (RTP) and color stability of thermally aged CAD-CAM glass-ceramics with glazing or polishing. Three different CAD-CAM blocks-feldspathic (VM), lithium disilicate (IPS), and zirconia-reinforced lithium silicate ceramic (VS)-were used in this study. The specimens were divided into two groups (n=10) according to surface treatments (glazing or polishing). Bleaching treatment with 16% CP was applied to the thermally aged specimens. A spectrophotometer (VITA Easyshade Advance) was used to measure the CIE L*a*b*coordinates of the specimens on white and black backgrounds, and RTP and color difference (ΔE00) values were calculated. The surface topography of the specimens and the atomic weight of the elements were analyzed with scanning electron microscopy and energy-dispersive x-ray. The data were analyzed by using the two-way ANOVA test for ΔE00 values and two-way repeated measures ANOVA test for RTP and color parameters values (a=0.05) and the Tukey post-hoc test was used for multiple comparisons of the groups. RTP values were statistically influenced by material type, bleaching, and finishing technique, and the interaction among these factors was found to be significant (p<0.05). ΔE00 values were statistically influenced by material type, finishing technique, and the interaction among these factors was also found to be significant (p<0.05). IPS presented significantly lower RTP and ΔE00 values for both glazed and polished surfaces (p<0.05). 16% CP bleaching agent caused changes in translucency of aged VM and IPS at different levels. Glazed surfaces presented higher color stability in comparison to mechanically polished surfaces for VS (p<0.05).