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1.
J Environ Manage ; 325(Pt B): 116612, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36323122

RESUMO

This study conducted randomized controlled trials to evaluate the effectiveness of an environmental education class and the impacts of nudges and boosts implemented in this program on high school students' basic knowledge, attitudes, and behaviors regarding environmental issues in Japan. This environmental education class consisted of a lecture on reducing the use of plastic products for energy conservation in daily life, a board game for learning how to reduce plastic waste, and a worksheet for reflection. Four types of worksheets were randomly distributed: nudges, in which students were asked to set a goal regarding their level of effort in not throwing away plastic products such as plastic bags, wet wipes, and plastic bottles; boosts, in which participants were asked to write an essay to help increase their empathy for the parties impacted by environmental issues; both nudges and boosts; and none (neither nudges nor boosts). After environmental education, an end-line survey was conducted to evaluate the effectiveness of this class. This study found that the environmental education class significantly improved students' basic environmental knowledge and promoted their concerns about plastic waste. Although there was no evidence that nudges and boosts amplify the effects of the environmental education class on the students' knowledge, nudges were successful in making them more concerned about plastic waste. The results showed that students who received nudges or boosts were more likely to refuse free wet wipes offered at convenience stores but were not more likely to refuse plastic bottles. These results also indicated that interventions through environmental education can change students' pro-environmental behaviors only if the cost of behavioral change is low. The environmental education class not only increased students' environmental knowledge and attitudes, but the use of worksheets in administering nudges and boosts ensured the effectiveness of environmental education.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Estudantes , Humanos , Conhecimento , Empatia , Plásticos , Ensaios Clínicos Controlados Aleatórios como Assunto
2.
J Exp Child Psychol ; 226: 105546, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36099753

RESUMO

Previous research established that children with poorer taxonomic knowledge in the food domain display increased levels of food rejection. However, the food domain heavily lends itself to script and thematic conceptual knowledge (e.g., pancakes at breakfast), to which young children already attend. This series of studies investigated the development of conceptual knowledge, specifically in the food domain, and the link with food rejection. Study 1 used a nonconflicting triad task testing children's knowledge of four subtypes of script and thematic associations (food-food pairs, food-utensil pairs, event scripts, and meal scripts) with children aged 3-6 years living in the United States (18 males and 14 females). Study 2 employed the same design along with a measure of food rejection in 3- to 6-year-olds living in France (67 males and 62 females). There was significant conceptual development in both groups, but thematic food concepts are acquired earlier than meal script concepts. Study 3 investigated the link between thematic and script cross-classification and food rejection in 39 females and 33 males living in France (4- to 7-year-olds). Results demonstrate that children as young as 3 years old are already attending to thematic and script structures to inform food-based decision making. Even more critically, Study 3 showed that increased food rejection tendencies are negatively related to script and thematic understanding in the food domain. Such seminal studies illustrate the importance of conceptual knowledge in children's interpretation and acceptance of food, highlighting promising avenues for knowledge-based interventions to foster dietary variety.


Assuntos
Formação de Conceito , Alimentos , Criança , Masculino , Feminino , Humanos , Pré-Escolar , Conhecimento , França
3.
Cognition ; 230: 105255, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36088669

RESUMO

The standard view on explicit theory of mind development holds that children around the age of 4 years start to ascribe beliefs to themselves and others, typically tested with false belief (FB) tasks. The present study (N = 95, 53 female, 41 male, Austrian, 41 to 80 months) systematically investigated the puzzling phenomenon that FB achievers (FB+) fail knowledge (often subsumed under "true belief") tasks: Despite the story protagonist witnessing the displacement of an object these children predict that the protagonist will look for it in its original location. We replicate this result in Experiment 1. Interestingly, some of our children indicated uncertainty about the protagonist's awareness of the relevant event. Thus, in Experiment 2 a new active watching condition was designed to help children understand that the protagonist attended to the critical event. This practically eradicated the knowledge error. Experiment 3 successfully replicated these results. Implications for existing explanations, perceptual access reasoning (PAR, Fabricius, Boyer, Weimer, & Carroll, 2010) and pragmatic difficulties (Oktay-Gür & Rakoczy, 2017) are discussed.


Assuntos
Conhecimento , Teoria da Mente , Criança , Masculino , Humanos , Feminino , Pré-Escolar , Resolução de Problemas , Cognição
4.
Cognition ; 230: 105293, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36191356

RESUMO

Infants generate basic expectations about their physical and social environment. This early knowledge allows them to identify opportunities for learning, preferring to explore and learn about objects that violate their prior expectations. However, less is known about how expectancy violations about people's actions influence infants' subsequent learning from others and about others. Here, we presented 18-month-old infants with an agent who acted either efficiently (expected action) or inefficiently (unexpected action) and then labeled an object. We hypothesized that infants would prefer to learn from the agent (label-object association) if she previously acted efficiently, but they would prefer to learn about the agent (voice-speaker association) if she previously acted inefficiently. As expected, infants who previously saw the agent acting efficiently showed greater attention to the demonstrated object and learned the new label-object association, but infants presented with the inefficient agent did not. However, there was no evidence that infants learned the voice-speaker association in any of the conditions. In summary, expectancy violations about people's actions may signal a situation to avoid learning from them. We discussed the results in relation to studies on surprise-induced learning, motionese, and selective social learning, and we proposed other experimental paradigms to investigate how expectancy violations influence infants' learning about others.


Assuntos
Desenvolvimento Infantil , Aprendizado Social , Lactente , Feminino , Humanos , Conhecimento
5.
Cognition ; 230: 105303, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36399971

RESUMO

The present paper reports two experiments (N = 232, 254) addressing the question: How do reasoners reconcile the desire to have useable (i.e., invariant) causal knowledge - knowledge that holds true when applied in new circumstances/contexts - with the reality that causes often interact with other causes present in the context? The experiments test two views of how reasoners learn and generalize potentially complex causal knowledge. Previous work has focused on reasoners' ability to learn rules (functions) describing how pre-defined candidate causes combine, potentially interactively, to produce an outcome in a domain. This empirical-function-learning view predicts that participants would generalize an acquired combination rule based on similarity to stimuli they experienced in the domain. An alternative causal-invariance view goes beyond empirical learning: it allows for the possibility that one's current representation may not yield useable causal knowledge. This view posits that the human causal-induction process incorporates invariant knowledge as an aspiration, entailing that observed deviation from causal invariance when the knowledge is applied serves as a signal for a need to revise causal knowledge: Only invariance across contexts with potentially new causal factors justifies generalization across them. The invariance view therefore predicts that reasoners would revise their representation so that they have whole causes - potentially consisting of interacting components - that do not interact with each other, even when in their relevant experience all (pre-defined) causes interact. Across both experiments, our results favor the causal-invariance view: Participants generalize their empirically learned function (which may involve interactions) to new stimuli, but switch to the analytic causal-invariance function for both old and new stimuli at the level of the whole cause, indicating that how humans want causes to combine their effects shapes the knowledge they induce.


Assuntos
Conhecimento , Aprendizagem , Humanos , Causalidade , Generalização Psicológica
6.
Braz. j. oral sci ; 21: e228274, jan.-dez. 2022. tab
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1392982

RESUMO

Parents are responsible for their children's health care, and their oral health-related knowledge, attitude, and habits can affect their children's oral health. Aim: The objective of this study was to evaluate parents' knowledge, attitudes, and practices regarding their children's oral health. Methods: In this study, a sample of 398 parents of 4- to 6-year-old children completed a self-designed questionnaire. The parents' oral health-related knowledge, attitudes, and practices were assessed. Children's oral health was evaluated using decayed, missing, and filled tooth index (dmft). Data were analyzed using the SPSS version 23.0 with a p < 0.05 as statistically significant. Categorical data were reported as frequency (%), and continuous data were reported as mean ± SD. Moreover, Spearman's correlation, multiple regression, Mann-Whitney test, Kruskal Wallis test, and Kolmogorov-Smirnov test were used. Results: Most of the parents had a satisfactory level of knowledge and positive attitudes regarding their children's oral health. The knowledge and attitude scores were higher among parents with higher education (p<0.001), and the knowledge score was higher among mothers (p=0.004). Also, the attitude score was correlated with the number of decayed, missed, and filled teeth of children (p=0.01, p=0.04, and p=0.007, respectively). However, there was no significant relationship between dmft and the parents' knowledge, attitudes, and practices using multiple regression. The mean dmft of children was 6.86 ± 3.56, and most of the parents had poor oral health-related practices. Conclusion: The parents' level of knowledge and attitudes were satisfactory, but they had poor oral health practices. Moreover, there was no significant relationship between children's oral health and their parents' level of knowledge, attitudes, and practices. Educating programs and strategies are needed to enhance parents' oral health-related attitudes and knowledge and, more importantly, change their oral health practices


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Pais , Criança , Saúde Bucal , Educação em Saúde Bucal , Inquéritos e Questionários , Conhecimento
7.
Enfoque Revista Científica de Enfermería ; 31(27): 24-38, jul.-dic.2022. ilus
Artigo em Espanhol | LILACS, BDENF - Enfermagem | ID: biblio-1380493

RESUMO

Los ensayos y escritos relacionados con el cuidado del paciente renal a través de los años se han enfocado a la calidad de vida, estilos de afrontamiento, satisfacción o percepciones que experimentan los pacientes durante su enfermedad. El presente articulo pretende reconocer que el cuidado de enfermería para con el paciente renal es un aspecto fundamental que proporciona al profesional la comprensión de la realidad del paciente y contribuye de manera positiva a comprender la realidad de enfermería como disciplina; enmarcadas en algunas posiciones que permiten garantizar su significado. Estas posiciones son la ética, la ontología y la epistemología. La ética se logra cuando el profesional de enfermería consigue proteger y respetar la dignidad humana del paciente renal que reciben atención de salud, la ontología se ocupa de reflexionar acerca de las concepciones de la realidad y sus relaciones centrando su finalidad en la búsqueda de la salud, del bienestar, la independencia y la trascendencia del paciente renal y la epistemología consiste en mostrar, de manera holística, la evolución del conocimiento de la enfermería para brindar un cuidado de excelencia al paciente renal.


Abstract Over the years, essays and writings related to kidney patient care have focused on quality of life, coping styles, satisfaction, or perceptions experienced by patients during their illness. This article aims to recognize that nursing care for kidney patients is a fundamental aspect that provides the professional with an understanding of the patient's reality and contributes positively to understanding the reality of nursing as a discipline framed in some positions that guarantee their meaning. These positions are ethics, ontology, and epistemology. Ethics is achieved when the nursing professional manages to protect and respect the human dignity of kidney patients who receive health care. Ontology deals with reflecting on the conceptions of reality and their relationships, focusing its purpose on the search for health, well-being, independence, and transcendence of kidney patients. And epistemology consists of showing, in a holistic way, the evolution of nursing knowledge to provide excellent care to kidney patients.


Resumo: Ensaios e escritos relacionados com os cuidados aos pacientes renais ao longo dos anos têmse focado na qualidade de vida, estilos de enfrentamento, satisfação ou percepções que os pacientes experimentam durante a sua doença. Este artigo tem como objetivo reconhecer que o cuidado de enfermagem para o doente renal é um aspecto fundamental que proporciona ao profissional uma compreensão da realidade do doente e contribui positivamente para a compreensão da realidade da enfermagem como disciplina; emoldurado em algumas posições que permitem garantir seu significado. Estas posições são ética, ontologia e epistemología. A ética é alcançada quando o profissional de enfermagem consegue proteger e respeitar a dignidade humana do paciente renal que recebe cuidados de saúde, a ontologia se preocupa em refletir sobre as concepções da realidade e as suas relações centrando o seu propósito na procura de saúde, bem-estar, independência e transcendência do paciente renal e epistemologia consiste em mostrar, holisticamente, a evolução do conhecimento de enfermagem para prestar um excelente cuidado ao paciente renal.


Assuntos
Humanos , Masculino , Feminino , Idoso , Conhecimento , Ética , Nefropatias/enfermagem , Cuidados de Enfermagem , Qualidade de Vida , Diagnóstico de Enfermagem , Conforto do Paciente
9.
Sci Rep ; 12(1): 20224, 2022 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-36418365

RESUMO

Changes in gene expression have been thought to play a crucial role in various types of cancer. With the advance of high-throughput experimental techniques, many genome-wide studies are underway to analyze underlying mechanisms that may drive the changes in gene expression. It has been observed that the change could arise from altered DNA methylation. However, the knowledge about the degree to which epigenetic changes might cause differences in gene expression in cancer is currently lacking. By considering the change of gene expression as the response of altered DNA methylation, we introduce a novel analytical framework to identify epigenetic subnetworks in which the methylation status of a set of highly correlated genes is predictive of a set of gene expression. By detecting highly correlated modules as representatives of the regulatory scenario underling the gene expression and DNA methylation, the dependency between DNA methylation and gene expression is explored by a Bayesian regression model with the incorporation of g-prior followed by a strategy of an optimal predictor subset selection. The subsequent network analysis indicates that the detected epigenetic subnetworks are highly biologically relevant and contain many verified epigenetic causal mechanisms. Moreover, a survival analysis indicates that they might be effective prognostic factors associated with patient survival time.


Assuntos
Metilação de DNA , Epigenômica , Humanos , Teorema de Bayes , Epigênese Genética , Conhecimento
10.
Sci Rep ; 12(1): 20126, 2022 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-36418853

RESUMO

To help advance exchanges between science and policy, a useful first step is to examine the questions which policymakers pose to scientists. The style of a question indicates what the asker is motivated to know, and how they might use that knowledge. Therefore, the aggregate pattern of typical policy inquires can help scientists anticipate what types of information policy audiences desire. A dataset (n = 2972) of questions from policymakers collected over 10 years (2011-2021)-by the Centre for Science and Policy at the University of Cambridge-was classified into one of seven classes. In the main, the most popular questions posed by policymakers-within the public and private sectors-were those whose answers inform how to achieve specific outcomes-whether directly, or by providing a causal analysis which is instrumental to this process. Moreover, this seems to be a general aspect of policymakers' inquiries, given that it is preserved regardless of the policy issue considered (e.g., Artificial Intelligence, Economy, or Health). Thus, maximizing the usefulness of the information that policymakers receive when engaging with scientists requires informing how to achieve specific outcomes-directly, or by providing a useful causal analysis.


Assuntos
Inteligência Artificial , Médicos , Humanos , Políticas , Conhecimento , Setor Privado
11.
BMC Med Educ ; 22(1): 806, 2022 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-36419055

RESUMO

BACKGROUND: Amid concerns about the decline of empathy during the clinical training of medical clerks, evidence that empathy improves patient outcomes suggests some potential for teaching empathy in ways that will affect the knowledge, attitude and behaviour of medical clerks. This potential alone cannot, however, guarantee the success of educational innovations to introduce empathy to the medical curriculum. This research aims to identify the barriers and facilitators of the implementation of a specific clinical initiative to enhance the empathy skills of clerks, namely the training of clerks to act as a 'MedGezel' or 'medical coach'. METHOD: We conducted an explorative qualitative study based on interview data collected and analyzed using reflexive thematic analysis and the readiness for change theory. We conducted semi-structured interviews with relevant stakeholders in this particular qualitative study. Thematic analysis was based on open and axial coding using ATLAS.ti 9, which facilitated the emergence of common themes of interest and meaning for the study. RESULTS: A total of 13 relevant stakeholders participated as interviewees in our study. The data was collected from April to June 2021. Our analysis generated 6 main themes which can provide insights into why the implementation of the MedGezel educational innovation failed so far. The following themes emerged: the case for change: why change?; practical necessity; leadership; management and resources; staff culture; and alignment with the corporate strategy. DISCUSSION: The implementation failure can be partially explained as resulting from the personal attitudes and choices of participants, who struggled to reconcile a vision that they liked with side effects that they feared. While participants repeatedly mentioned management and leadership issues, these organizational issues seemed less important as they could be easily resolved in practice. What was more important and fatal for the initiative was its lack of alignment with staff culture, despite its alignment with corporate strategy. CONCLUSION: This investigation into the barriers and facilitators influencing the implementation of the MedGezel program identified 6 explanatory themes, the most impactful one being staff culture.


Assuntos
Currículo , Empatia , Humanos , Escolaridade , Emoções , Conhecimento
12.
Hist Philos Life Sci ; 44(4): 65, 2022 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-36417009

RESUMO

What sets someone on a life trajectory? This question is at the heart of studies of 21st-century neurosciences that build on scientific models developed over the last 150 years that attempt to link psychopathology risk and human development. Historically, this research has documented persistent effects of singular, negative life experiences on people's subsequent development. More recently, studies have documented neuromolecular effects of early life adversity on life trajectories, resulting in models that frame lives as disproportionately affected by early negative experiences. This view is dominant, despite little evidence of the stability of the presumably early-developed molecular traits and their potential effects on phenotypes. We argue that in the context of gaps in knowledge and the need for scientists to reason across molecular and phenotypic scales, as well as time spans that can extend beyond an individual's life, specific interpretative frameworks shape the ways in which individual scientific findings are assessed. In the process, scientific reasoning oscillates between understandings of cellular homeostasis and organisms' homeorhesis, or life trajectory. Biologist and historian François Jacob described this framework as the "attitude" that researchers bring to bear on their "objects" of study. Through an analysis of, first, historical and contemporary scientific literature and then ethnographic research with neuroscientists, we consider how early life trauma came to be associated with specific psychological and neurobiological effects grounded in understandings of life trajectories. We conclude with a consideration of the conceptual, ontological, and ethical implications of interpreting life trajectories as the result of the persistence of long-embodied biological traits, persistent life environments, or both.


Assuntos
Conhecimento , Neurobiologia , Humanos , Antropologia Cultural , Princípios Morais , Lógica
13.
BMC Bioinformatics ; 23(1): 501, 2022 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-36418937

RESUMO

BACKGROUND: Automatic and accurate recognition of various biomedical named entities from literature is an important task of biomedical text mining, which is the foundation of extracting biomedical knowledge from unstructured texts into structured formats. Using the sequence labeling framework and deep neural networks to implement biomedical named entity recognition (BioNER) is a common method at present. However, the above method often underutilizes syntactic features such as dependencies and topology of sentences. Therefore, it is an urgent problem to be solved to integrate semantic and syntactic features into the BioNER model. RESULTS: In this paper, we propose a novel biomedical named entity recognition model, named BioByGANS (BioBERT/SpaCy-Graph Attention Network-Softmax), which uses a graph to model the dependencies and topology of a sentence and formulate the BioNER task as a node classification problem. This formulation can introduce more topological features of language and no longer be only concerned about the distance between words in the sequence. First, we use periods to segment sentences and spaces and symbols to segment words. Second, contextual features are encoded by BioBERT, and syntactic features such as part of speeches, dependencies and topology are preprocessed by SpaCy respectively. A graph attention network is then used to generate a fusing representation considering both the contextual features and syntactic features. Last, a softmax function is used to calculate the probabilities and get the results. We conduct experiments on 8 benchmark datasets, and our proposed model outperforms existing BioNER state-of-the-art methods on the BC2GM, JNLPBA, BC4CHEMD, BC5CDR-chem, BC5CDR-disease, NCBI-disease, Species-800, and LINNAEUS datasets, and achieves F1-scores of 85.15%, 78.16%, 92.97%, 94.74%, 87.74%, 91.57%, 75.01%, 90.99%, respectively. CONCLUSION: The experimental results on 8 biomedical benchmark datasets demonstrate the effectiveness of our model, and indicate that formulating the BioNER task into a node classification problem and combining syntactic features into the graph attention networks can significantly improve model performance.


Assuntos
Idioma , Semântica , Fala , Conhecimento , Benchmarking
14.
BMC Geriatr ; 22(1): 886, 2022 Nov 22.
Artigo em Inglês | MEDLINE | ID: mdl-36418953

RESUMO

BACKGROUND: The 25-item Dementia Knowledge Assessment Scale (DKAS2) is a widely used tool for measuring knowledge of dementia. To increase the applicability of the Chinese-language version of the tool (DKAS-TC) for the general public, this study aimed to develop a shortened version using the item response theory (IRT) approach. METHODS: A total of 401 participants voluntarily completed a Chinese-language version of the DKAS2 questionnaire (DKAS-TC) at the start of dementia awareness training courses in 2020 and 2021. The four Rasch family models were used to analyze the dimensionality of the shortened scale (the DKAS-s) and to confirm its accuracy in measuring dementia knowledge. RESULTS: The results justified supported the use of a dichotomous response scale for responding to the DKAS-s and demonstrated good fit of the data to a Rasch model with the four dimensions of "Causes and Characteristics", "Communication and Engagement", "Care Needs", and "Risks and Health Promotion". Moreover, we shortened the DKAS-TC by selecting items that had both above-average discriminative ability and above-average information. The DKAS-s retained 64.13% of the information contained in the DKAS-TC, resulting in a 16-item scale which retained four items in each of the original four dimensions. The DKAS-s also correlated highly (≥0.95) with the DKAS-TC and exhibited a sizeable range of difficulty of dementia knowledge. CONCLUSIONS: The DKAS-s is expected to be more efficient in field settings while retaining an acceptable level of psychometric properties when used as a survey instrument to measure the general public's knowledge of dementia.


Assuntos
Demência , Humanos , Demência/diagnóstico , Taiwan/epidemiologia , Psicometria/métodos , Conhecimento , Inquéritos e Questionários
15.
J Nurs Adm ; 52(12): 629-631, 2022 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-36409252

RESUMO

Leadership competencies represent the knowledge, skills, and abilities associated with effective leadership. This fall, the American Organization for Nursing Leadership published its core nursing leadership competencies that are intended to be measurable and translatable across the care continuum and throughout all levels of nursing leadership. In this column, the authors discuss these updated competencies and the relevance to practice, academia, and industry.


Assuntos
Indústrias , Liderança , Humanos , Conhecimento , Continuidade da Assistência ao Paciente
16.
PLoS Negl Trop Dis ; 16(11): e0010841, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36409666

RESUMO

Snakebite envenoming remains a public health threat in many African countries, including Malawi. However, there is a shortage of literature on the knowledge of Health Care Workers (HCWs) and the prevalence of snakebite cases in Malawi. We interviewed HCWs in Neno District to assess their knowledge of snake identification and management of snakebites. We further reviewed patient registers from 2018 to 2021 in all 15 health facilities in the district. We used descriptive statistics to characterize the survey population, knowledge, snake antivenom (SAV) administration, and snake identification. Using "shapefiles" from Open Street Maps, we mapped villages with snakebite cases. Of the 105 HCWs interviewed, 58% were males, and 60% had worked for less than five years. The majority (n = 93, 89%) reported that snakebite envenoming was a problem in the district. Among the clinicians, 42% said they had prescribed SAV previously, while among nurses, only 26% had ever administered SAV. There were discrepancies among clinicians regarding the dosing of snake antivenom. Significant gaps in knowledge also existed regarding snake identification. While two-thirds of HCWs could correctly name and identify venomous snake species, most (> 90%) failed for non-venomous snakes. Most (n = 100, 95%) reported that snakebite victims visit traditional healers more than the hospital. Between 2018 and 2021, the Neno District registered 185 snakebites with a yearly average of 36 cases per 100,000 population. Fifty-two percent (n = 97) were treated as an inpatient; of these cases, 72% were discharged in less than three days, and two died. More snakebite cases were recorded in the eastern part of the district. Significant knowledge gaps exist among HCWs in Neno regarding prescription and administration of SAV and snake identification, which likely challenges the quality of services offered to snakebite victims.


Assuntos
Mordeduras de Serpentes , Masculino , Humanos , Feminino , Mordeduras de Serpentes/epidemiologia , Mordeduras de Serpentes/terapia , Antivenenos/uso terapêutico , Malaui/epidemiologia , Conhecimento , Pessoal de Saúde
17.
Database (Oxford) ; 20222022 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-36412326

RESUMO

Plague has been confirmed as an extremely horrific international quarantine infectious disease attributed to Yersinia pestis. It has an extraordinarily high lethal rate that poses a serious hazard to human and animal lives. With the deepening of research, there has been a considerable amount of literature related to the plague that has never been systematically integrated. Indeed, it makes researchers time-consuming and laborious when they conduct some investigation. Accordingly, integrating and excavating plague-related knowledge from considerable literature takes on a critical significance. Moreover, a comprehensive plague knowledge base should be urgently built. To solve the above issues, the plague knowledge base is built for the first time. A database is built from the literature mining based on knowledge graph, which is capable of storing, retrieving, managing and accessing data. First, 5388 plague-related abstracts that were obtained automatically from PubMed are integrated, and plague entity dictionary and ontology knowledge base are constructed by using text mining technology. Second, the scattered plague-related knowledge is correlated through knowledge graph technology. A multifactor correlation knowledge graph centered on plague is formed, which contains 9633 nodes of 33 types (e.g. disease, gene, protein, species, symptom, treatment and geographic location), as well as 9466 association relations (e.g. disease-gene, gene-protein and disease-species). The Neo4j graph database is adopted to store and manage the relational data in the form of triple. Lastly, a plague knowledge base is built, which can successfully manage and visualize a large amount of structured plague-related data. This knowledge base almost provides an integrated and comprehensive plague-related knowledge. It should not only help researchers to better understand the complex pathogenesis and potential therapeutic approaches of plague but also take on a key significance to reference for exploring potential action mechanisms of corresponding drug candidates and the development of vaccine in the future. Furthermore, it is of great significance to promote the field of plague research. Researchers are enabled to acquire data more easily for more effective research. Database URL: http://39.104.28.169:18095/.


Assuntos
Peste , Animais , Humanos , Reconhecimento Automatizado de Padrão , Bases de Dados Factuais , Conhecimento , Bases de Conhecimento
20.
Brief Bioinform ; 23(6)2022 Nov 19.
Artigo em Inglês | MEDLINE | ID: mdl-36347537

RESUMO

Target discovery and identification processes are driven by the increasing amount of biomedical data. The vast numbers of unstructured texts of biomedical publications provide a rich source of knowledge for drug target discovery research and demand the development of specific algorithms or tools to facilitate finding disease genes and proteins. Text mining is a method that can automatically mine helpful information related to drug target discovery from massive biomedical literature. However, there is a substantial lag between biomedical publications and the subsequent abstraction of information extracted by text mining to databases. The knowledge graph is introduced to integrate heterogeneous biomedical data. Here, we describe e-TSN (Target significance and novelty explorer, http://www.lilab-ecust.cn/etsn/), a knowledge visualization web server integrating the largest database of associations between targets and diseases from the full scientific literature by constructing significance and novelty scoring methods based on bibliometric statistics. The platform aims to visualize target-disease knowledge graphs to assist in prioritizing candidate disease-related proteins. Approved drugs and associated bioactivities for each interested target are also provided to facilitate the visualization of drug-target relationships. In summary, e-TSN is a fast and customizable visualization resource for investigating and analyzing the intricate target-disease networks, which could help researchers understand the mechanisms underlying complex disease phenotypes and improve the drug discovery and development efficiency, especially for the unexpected outbreak of infectious disease pandemics like COVID-19.


Assuntos
COVID-19 , Humanos , Mineração de Dados/métodos , Publicações , Conhecimento , Algoritmos , Proteínas
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