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1.
Sci Rep ; 12(1): 7683, 2022 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-35538179

RESUMO

The aims of this study were to evaluate the biological activities of black Dimocarpus longan Lour. seed extracts and develop a lamellar liquid crystal (LLC). Different solvents, including petroleum ether, ethyl acetate, and 95% v/v ethanol, were used in the maceration of black D. longan seeds. The inhibitory activities on matrix metalloproteinase-1 (MMP-1) and hyaluronidase were evaluated. The irritating potency of D. longan seed extracts was determined using the hen's egg chorioallantoic membrane test. The extract with the strongest anti-ageing activities and no irritant impact was examined for its chemical contents using high-performance liquid chromatography and incorporated into the LLC. Various factors affecting the LLC formulations, including surfactant types and amounts, thickening agent types and amounts, and various oil types, were investigated. The results demonstrated that the ethyl acetate extract (EtOAc) was the most potent inhibitor of MMP-1 (IC50 = 21.7 ± 5.4 µg/mL) and hyaluronidase (oleanolic acid equivalent = 0.44 ± 0.03 g per g extract). Interestingly, its MMP-1 inhibition was equivalent to that of oleanolic acid, corilagin, and gallic acid. Furthermore, its hyaluronidase inhibition was equivalent to that of gallic acid and ellagic acid. Gallic acid, which was the most abundant compound (15.6% ± 0.06% w/w) was suggested as the compound responsible for the biological activities of EtOAc extract. Considering its potential anti-skin ageing properties with no irritation of EtOAc extract, it was incorporated into the most suitable LLC, which was composed of 5% w/w Lexfeel® D5 oil, 0.5% w/w Carbopol® U21, 2% w/w Liquid Crystal Cream Maker, and 92.5% w/w DI water. The LLC containing EtOAc extract presented birefringence under a polarizing light microscope, indicating its crystallinity. The formulation had good stability after heating-cooling cycles in terms of external appearance, crystallinity, viscosity, and pH (5.5). As a result, it is recommended as a potential cosmeceutical formulation for anti-skin wrinkling. It is proposed that more research be conducted on the safety and efficacy of the treatment on human volunteers.


Assuntos
Cosmecêuticos , Cristais Líquidos , Ácido Oleanólico , Animais , Galinhas , Cosmecêuticos/análise , Feminino , Ácido Gálico/farmacologia , Humanos , Hialuronoglucosaminidase , Metaloproteinase 1 da Matriz , Extratos Vegetais/química , Sapindaceae , Sementes/química
2.
Oxid Med Cell Longev ; 2022: 3486257, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35387261

RESUMO

We previously annotated the phytochemical constituents of a root extract from Ximenia americana var. caffra and highlighted its hepatoprotective and hypoglycemic properties. We here extended our study on the leaf extract and identified its phytoconstituents using HPLC-PDA-ESI-MS/MS. In addition, we explored its antioxidant, antibacterial, and antiaging activities in vitro and in an animal model, Caenorhabditis elegans. Results from HPLC-PDA-ESI-MS/MS confirmed that the leaves contain 23 secondary metabolites consisting of condensed tannins, flavonol glycosides, flavone glycosides, and flavonol diglycosides. The leaf extract demonstrated significant antioxidant activity in vitro with IC50 value of 5 µg/mL in the DPPH assay and 18.32 µg/mL in the FRAP assay. It also inhibited four enzymes (collagenase, elastase, hyaluronidase, and tyrosinase) crucially involved in skin remodeling and aging processes with comparable activities to reference drugs along with four pure secondary metabolites identified from the extract. In accordance with the in vitro result, in vivo tests using two transgenic strains of C. elegans demonstrated its ability to reverse oxidative stress. Evidence included an increased survival rate in nematodes treated with the prooxidant juglone to 68.9% compared to the 24.8% in untreated worms and a reduced accumulation of intracellular reactive oxygen species (ROS) in a dose-dependent manner to 77.8%. The leaf extract also reduced levels of the expression of HSP 16.2 in a dose-dependent manner to 86.4%. Nuclear localization of the transcription factor DAF-16 was up to 10 times higher in worms treated with the leaf extract than in the untreated worms. The extract also inhibited the biofilm formation of Pseudomonas aeruginosa (a pathogen in skin infections) and reduced the swimming and swarming mobilities in a dose-dependent fashion. In conclusion, leaves of X. americana are a promising candidate for preventing oxidative stress-induced conditions, including skin aging.


Assuntos
Cosmecêuticos , Olacaceae , Animais , Antibacterianos/farmacologia , Antioxidantes/metabolismo , Caenorhabditis elegans/metabolismo , Cosmecêuticos/metabolismo , Cosmecêuticos/farmacologia , Glicosídeos/farmacologia , Olacaceae/metabolismo , Estresse Oxidativo , Compostos Fitoquímicos/farmacologia , Extratos Vegetais/química , Espécies Reativas de Oxigênio/metabolismo , Espectrometria de Massas em Tandem
3.
J Agric Food Chem ; 70(16): 4981-4994, 2022 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-35420422

RESUMO

Blue gum (Eucalyptus globulus) is a widely used botanical in the cosmeceutical and food industries. Although blue gum leaves are known for abundant essential oils, their nonvolatile phytochemical constituents and bioactivities remain unclear. Herein, a phytochemical investigation of blue gum leaves led to the identification of eight new monoterpene acid and gallic acid glucose esters (1-4 and 14-17; glubosides A-H, respectively) and 12 known analogues (5-13 and 18-20). Their structures were determined based on extensive spectroscopic data analysis, chemical degradation, and chiral separation. Oleuropeic acid conjugated glucose esters (1-13, 15, 16, 18, and 20) are reported as epimeric mixtures. Compounds 7, 12, 14, 19, and 20 (at 30 µM) inhibited nitrite release in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Compounds 7 and 14 (at 3-30 µM) also down-regulated proinflammatory biomarkers, including cytokines (TNF-α, IL-6, and IL-1ß), protein expression (iNOS and COX-2), and transcription factor nuclear translocation (NF-κB) in LPS-stimulated RAW264.7 cells. This work highlights the anti-inflammatory potential of phytochemicals from blue gum leaves, which supports their further development as cosmeceutical and/or nutraceutical products.


Assuntos
Cosmecêuticos , Eucalyptus , Anti-Inflamatórios/química , Cosmecêuticos/análise , Citocinas/metabolismo , Ésteres/análise , Ésteres/farmacologia , Eucalyptus/química , Ácido Gálico/química , Glucose/análise , Lipopolissacarídeos/farmacologia , Monoterpenos/química , NF-kappa B/metabolismo , Compostos Fitoquímicos/análise , Folhas de Planta/química
4.
Biomed Res Int ; 2022: 1725053, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35342760

RESUMO

Objective: Multiple emulsions have the ability to incorporate both lipophilic and hydrophilic actives in the same preparation and facilitate permeation of active ingredients through skin. The current study was aimed at formulating niacinamide/ferulic acid-loaded stable multiple emulsion (MNF) and its in vitro/in vivo characterization as a cosmeceutical product. Methods: Both the compounds were evaluated for their radical scavenging potential by the DPPH method and FTIR analysis. Then, placebo and active formulations were prepared using a double emulsification method and were investigated for stability testing (changes in color, odor, and liquefaction on centrifugation, pH, and globule size) for a period of three months. Afterwards, MNF was investigated for in vitro sun protection factor, rheological studies, entrapment efficiency, zeta potential, zeta size, and ex vivo permeation. Moreover, after ensuring the hypoallergenicity and safety, it was also checked for its cosmeceutical effects on human skin using noninvasive biophysical probes in comparison with placebo. Results: Results demonstrated that MNF showed a non-Newtonian behavior rheologically and both MNF and placebo were stable at different storage conditions. Entrapment efficiency, zeta potential, and zeta size were 93.3%, -5.88 mV, and 0.173 µm, respectively. Moreover, melanin, sebum, and skin erythema were significantly reduced while skin elasticity and hydration were improved. Conclusion: It is evident that niacinamide and ferulic acid can be successfully incorporated in a stable multiple emulsion which has potent cosmeceutical effects on human skin.


Assuntos
Cosmecêuticos , Cosmecêuticos/farmacologia , Ácidos Cumáricos/farmacologia , Emulsões/química , Humanos , Niacinamida/farmacologia , Tamanho da Partícula , Pele
5.
Int J Mol Sci ; 23(5)2022 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-35270025

RESUMO

Sunlight is an important factor in regulating the central circadian rhythm, including the modulation of our sleep/wake cycles. Sunlight had also been discovered to have a prominent influence on our skin's circadian rhythm. Overexposure or prolonged exposure to the sun can cause skin photodamage, such as the formation of irregular pigmentation, collagen degradation, DNA damage, and even skin cancer. Hence, this review will be looking into the detrimental effects of sunlight on our skin, not only at the aspect of photoaging but also at its impact on the skin's circadian rhythm. The growing market trend of natural-product-based cosmeceuticals as also caused us to question their potential to modulate the skin's circadian rhythm. Questions about how the skin's circadian rhythm could counteract photodamage and how best to maximize its biopotential will be discussed in this article. These discoveries regarding the skin's circadian rhythm have opened up a completely new level of understanding of our skin's molecular mechanism and may very well aid cosmeceutical companies, in the near future, to develop better products that not only suppress photoaging but remain effective and relevant throughout the day.


Assuntos
Cosmecêuticos , Envelhecimento da Pele , Dermatopatias , Ritmo Circadiano/fisiologia , Cosmecêuticos/metabolismo , Humanos , Pele/metabolismo , Dermatopatias/metabolismo
6.
Exp Dermatol ; 31(5): 674-688, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-35338666

RESUMO

Skin ageing is predominantly caused by either intrinsic or extrinsic factors, leading to undesirable skin features. Advancements in both molecular and cellular fields have created possibilities in developing novel stem cell-derived active ingredients for cosmeceutical applications and the beauty industry. Mesenchymal stromal cell (MSC)-derived secretomes or conditioned media hold great promise for advancing skin repair and regeneration due to the presence of varying cytokines. These cytokines signal our cells and trigger biological mechanisms associated with anti-inflammatory, antioxidant, anti-ageing, proliferative and immunomodulatory effects. In this review, we discuss the potential of MSC secretomes as novel biomaterials for skincare and rejuvenation by illustrating their mechanism of action related to wound healing, anti-ageing and whitening properties. The advantages and disadvantages of secretomes are compared with both plant-based and animal-derived extracts. In addition, this paper reviews the current safety standards, regulations, market products and research work related to the cosmeceutical applications of secretomes along with strategies to maintain and improve the therapeutic efficacy and production of secretomes. The future outlook of beauty industry is also presented. Lastly, we highlight significant challenges to be addressed for the clinical realization of MSC secretomes-based skin therapies as well as providing perspectives for the future direction of secretomes.


Assuntos
Cosmecêuticos , Células-Tronco Mesenquimais , Animais , Cosmecêuticos/farmacologia , Meios de Cultivo Condicionados/farmacologia , Citocinas
7.
Molecules ; 27(4)2022 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-35209043

RESUMO

(1) Background: Acne is a widespread skin disease, especially among adolescents. Following the COVID-19 pandemic and the use of masks, the problem has been affecting a greater number of people, and the attention of the skin care beauty routine cosmetics has been focused on the "Maskne", caused by the sebum excretion rate (SER) that stimulates microbial proliferation. (2) Methods: the present study was focused on the rheological characterization and quality assurance of the preservative system of an anti-acne serum. The biological effectiveness (cytotoxicity-skin and eye irritation-antimicrobial, biofilm eradication and anti-inflammatory activity) was evaluated in a monolayer cell line of keratinocytes (HaCaT) and on 3D models (reconstructed human epidermis, RHE and human reconstructed corneal epithelium, HCE). The Cutibacterium acnes, as the most relevant acne-inducing bacterium, is chosen as a pro-inflammatory stimulus and to evaluate the antimicrobial activity of the serum. (3) Results and Conclusions: Rheology allows to simulate serum behavior at rest, extrusion and application, so the serum could be defined as having a solid-like behavior and being pseudoplastic. The preservative system is in compliance with the criteria of the reference standard. Biological effectiveness evaluation shows non-cytotoxic and irritant behavior with a good antimicrobial and anti-inflammatory activity of the formulation, supporting the effectiveness of the serum for acne-prone skin treatment.


Assuntos
Acne Vulgar/tratamento farmacológico , Antibacterianos , Biofilmes/efeitos dos fármacos , COVID-19 , Cosmecêuticos , Pandemias , Propionibacteriaceae/fisiologia , SARS-CoV-2 , Acne Vulgar/microbiologia , Antibacterianos/química , Antibacterianos/farmacologia , Linhagem Celular Transformada , Cosmecêuticos/química , Cosmecêuticos/farmacologia , Humanos
8.
Molecules ; 27(3)2022 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-35164093

RESUMO

Cosmetic-containing herbals are a cosmetic that has or is claimed to have medicinal properties, with bioactive ingredients purported to have medical benefits. There are no legal requirements to prove that these products live up to their claims. The name is a combination of "cosmetics" and "pharmaceuticals". "Nutricosmetics" are related dietary supplements or food or beverage products with additives that are marketed as having medical benefits that affect appearance. Cosmetic-containing herbals are topical cosmetic-pharmaceutical hybrids intended to enhance the health and beauty of the skin. Cosmetic-containing herbals improve appearance by delivering essential nutrients to the skin. Several herbal products, such as cosmetic-containing herbals, are available. The present review highlights the use of natural products in cosmetic-containing herbals, as natural products have many curative effects as well as healing effects on skin and hair growth with minimal to no side effects. A brief description is given on such plants, their used parts, active ingredients, and the therapeutic properties associated with them. Mainly, the utilization of phytoconstituents as cosmetic-containing herbals in the care of skin and hair, such as dryness of skin, acne, eczema, inflammation of the skin, aging, hair growth, and dandruff, along with natural ingredients, such as for hair colorant, are explained in detail in the present review.


Assuntos
Produtos Biológicos/uso terapêutico , Cosmecêuticos/uso terapêutico , Cosméticos/uso terapêutico , Envelhecimento da Pele/efeitos dos fármacos , Dermatopatias/tratamento farmacológico , Pele/metabolismo , Humanos
9.
Molecules ; 27(3)2022 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-35164116

RESUMO

The present work was performed to investigate the phenolic composition of P. lentiscus L. distilled leaves (PDL) and examine its potential against certain key enzymes related to skin aging. High-pressure liquid chromatography coupled to mass spectrometry (HPLC-MS) and various separation procedures combined with nuclear magnetic resonance (NMR) and MS analysis were performed to isolate and identify compounds present in the ethyl acetate extract (EAE) of PDL. A high amount of flavonol glycoside was detected in EAE. Indeed, quercetin-3-O-rhamnoside (FC), myricetin-3-O-rhamnoside (FM2), and kaempferol-3-O-rhamnoside (FB2) were isolated from EAE, and are present in high quantities of 10.47 ± 0.26, 12.17 ± 0.74, and 4.53 ± 0.59 mg/g dry weight, respectively. A transdermal diffusion study was carried out to determine the EAE-molecules that may transmit the cutaneous barrier and showed that FM2 transmits the membrane barrier with a high amount followed by FC. EAE, FM2, and FC were tested against tyrosinase and elastase enzymes. Moreover, intracellular tyrosinase inhibition and cytotoxicity on skin melanoma cells (B16) were evaluated. The results indicated that EAE, FC, and FM2 have important inhibitory activities compared to the well-known standards, at non-cytotoxic concentrations. Therefore, they could be excellent agents for treating skin pigmentation and elasticity problems.


Assuntos
Cosmecêuticos , Inibidores Enzimáticos , Monofenol Mono-Oxigenase/antagonistas & inibidores , Elastase Pancreática/antagonistas & inibidores , Compostos Fitoquímicos , Pistacia/química , Folhas de Planta/química , Absorção Cutânea/efeitos dos fármacos , Animais , Cosmecêuticos/química , Cosmecêuticos/farmacologia , Inibidores Enzimáticos/química , Inibidores Enzimáticos/farmacologia , Melanoma Experimental , Camundongos , Monofenol Mono-Oxigenase/metabolismo , Elastase Pancreática/metabolismo , Compostos Fitoquímicos/química , Compostos Fitoquímicos/farmacologia
10.
Molecules ; 27(2)2022 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-35056847

RESUMO

Olive leaf is a rich source of phenolic compounds with numerous activities related to skin health and appearance. In this study, a green extraction method was developed using eco-friendly solvents: polypropylene glycol (PPG), lactic acid (LA), and water. The optimal extraction conditions were established, including solvent, extraction time, technique (magnetic stirrer vs. ultrasound-assisted extraction), and herbal material/solvent ratio. The composition of the solvent mixture was optimized using a mixture design. The content of phenolic compounds, including oleuropein and verbascoside, was determined using high-performance liquid chromatography (HPLC) and spectrophotometric methods. Using different extraction conditions, three extracts were prepared and their phytochemical compositions and antioxidant and skin-related bioactivities were investigated. The extracts were excellent inhibitors of elastase, collagenase, tyrosinase, and lipoxygenase. The best activity was shown by the extract richest in phenolics and prepared using magnetic-stirrer-assisted extraction for 20 min, with 0.8 g of herbal material extracted in 10 mL of PPG/LA/water mixture (28.6/63.6/7.8, w/w/w), closely followed by the extract prepared using the same extraction conditions but with 0.42 g of herbal material. The investigated PPG/LA/water mixtures contributed to the overall enzyme-inhibitory activity of the extracts. The prepared extracts were appropriate for direct use in cosmetic products, thus saving the time and energy consumption necessary for the evaporation of conventional solvents.


Assuntos
Cosmecêuticos/farmacologia , Inibidores Enzimáticos/farmacologia , Olea/química , Fenóis/isolamento & purificação , Compostos Fitoquímicos/farmacologia , Extratos Vegetais/farmacologia , Folhas de Planta/química , Cosmecêuticos/isolamento & purificação , Ácido Láctico/química , Extratos Vegetais/isolamento & purificação , Polímeros/química , Propilenoglicóis/química
11.
J Cosmet Dermatol ; 21(4): 1588-1595, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34021684

RESUMO

BACKGROUND: Antioxidants are widely used in cosmetic products as they have beneficial effects on skin and prevent skin from harmful effects of environment. Albizia lebbeck has a significant potential to be used in cosmeceuticals due to its antioxidant activity. OBJECTIVES: The aim of this study was to formulate a stable and effective o/w emulsion-based emulgel containing Albizia lebbeck bark extract, which have considerable antioxidant activity. METHODOLOGY: Antioxidant activity of Albizia lebbeck bark extract was determined by DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Emulgel containing 3% extract was developed by mixing o/w emulsion in Carbopol gel along with a placebo emulgel without extract (base). In vitro evaluation of these emulgels, that is, liquefaction, color, phase separation, centrifugation, and pH change were carried out for a period of 8 weeks at different storage conditions, that is, 8ºC, 25ºC, 40ºC, and 40ºC & 75% relative humidity (RH). In vivo evaluation of emulgels was carried out on 13 healthy female volunteers by measuring various parameters of skin, that is, melanin level, erythema level, moisture content, sebum content, and elasticity at regular time intervals after applying emulgel (both base and test formulation) for 8 weeks. RESULTS: Antioxidant activity of Albizia lebbeck bark extract was 84.7%. Both emulgels (base and test formulation) were stable at all storage conditions. Statistical analysis showed that test formulation produced significant effects (p < 0.05) on melanin, erythema level, moisture content, sebum level, and elasticity of skin. CONCLUSION: It can be concluded that a stable topical emulgel containing 3% Albizia lebbeck bark extract has significant antioxidant effects on human skin.


Assuntos
Albizzia , Cosmecêuticos , Albizzia/química , Cosmecêuticos/farmacologia , Feminino , Humanos , Casca de Planta/química , Extratos Vegetais , Sebo
13.
J Cosmet Dermatol ; 21(4): 1407-1418, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34129742

RESUMO

BACKGROUND: Essential oils have great interest among the increasing demand for herbal cosmetics in the market. They are natural sources of biologically active ingredients due to the wide application of such compounds as well as their particular chemical composition. Several researches have evaluated the effectiveness of these bioactive ingredients for use in cosmeceuticals, mainly in both hair scalp and shaft hair damage repair. Thus, the amounts and their associations define the properties of these compositions with interest for hair cosmetic use, such as antioxidant, inflammatory, and antimicrobial activities. Because they are complex compounds, their actions on the skin, hair scalp, and shaft are not yet fully understood. AIMS: The purpose of this review is to highlight the relevant researches and findings on essential oils in hair care. METHODS: In order to achieve this objective, the present work comprises an updated bibliographic review related to essential oils used in hair care. RESULTS: It was possible to observe that cosmeceuticals containing essential oils applied to the scalp are preferable for topical activity. Also, it was noticed that there are few reports regarding their use in hair shaft. However, it was found that some oils are used to intensify the brightness and fix the hair color. CONCLUSIONS: This work demonstrated that the use of essential oils in both cosmetic products (industrial application) and those associated with oils carriers (as individual protocols) may lead to satisfactory results in the treatment of some scalp dysfunctions.


Assuntos
Cosmecêuticos , Cosméticos , Óleos Voláteis , Cosmecêuticos/química , Cosméticos/química , Cabelo , Humanos , Óleos Voláteis/farmacologia , Óleos Voláteis/uso terapêutico , Pele
14.
Molecules ; 26(24)2021 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-34946675

RESUMO

(1) Background: Cosmeceuticals are topical products applied to human skin to prevent skin ageing and maintain a healthy skin appearance. Their effectiveness is closely linked to the compounds present in a final formulation. In this article, we propose a panel of in vitro tests to support the efficacy assessment of an anti-ageing cream enriched with functional compounds. (2) Methods: biocompatibility and the irritant effect were evaluated on reconstructed human epidermis (RHE) and corneal epithelium (HCE) 3D models. After a preliminary MTT assay, normal human dermal fibroblasts (NHDF) and keratinocytes (HaCaT) were used to evaluate the extracellular matrix (ECM) protein synthesis, and interleukin-6 (IL-6) and metalloproteinase-1 (MMP-1) production. (3) Results: data collected showed good biocompatibility and demonstrated the absence of the irritant effect in both 3D models. Therefore, we demonstrated a statistical increase in collagen and elastin productions in NHDF cells. In HaCaT cells, we highlighted an anti-inflammatory effect through a reduction in IL-6 levels in inflammatory stimulated conditions. Moreover, the reduction of MMP-1 production after UV-B radiation was demonstrated, showing significant photo-protection. (4) Conclusion: a multiple in vitro assays approach is proposed for the valid and practical assessment of the anti-ageing protection, anti-inflammatory and biocompatible claims that can be assigned to a cosmetic product containing functional compounds.


Assuntos
Cosmecêuticos/farmacologia , Derme/metabolismo , Fibroblastos/metabolismo , Queratinócitos/metabolismo , Envelhecimento da Pele/efeitos dos fármacos , Linhagem Celular , Proteínas da Matriz Extracelular/biossíntese , Humanos , Interleucina-6/biossíntese , Metaloproteinase 1 da Matriz/biossíntese
15.
Mar Drugs ; 19(12)2021 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-34940661

RESUMO

A growing concern for overall health is driving a global market of natural ingredients not only in the food industry but also in the cosmetic field. In this study, a screening on potential cosmetic applications of aqueous extracts from three Icelandic seaweeds produced by pulsed electric fields (PEF) was performed. Produced extracts by PEF from Ulva lactuca, Alaria esculenta and Palmaria palmata were compared with the traditional hot water extraction in terms of polyphenol, flavonoid and carbohydrate content. Moreover, antioxidant properties and enzymatic inhibitory activities were evaluated by using in vitro assays. PEF exhibited similar results to the traditional method, showing several advantages such as its non-thermal nature and shorter extraction time. Amongst the three Icelandic species, Alaria esculenta showed the highest content of phenolic (mean value 8869.7 µg GAE/g dw) and flavonoid (mean value 12,098.7 µg QE/g dw) compounds, also exhibiting the highest antioxidant capacities. Moreover, Alaria esculenta extracts exhibited excellent anti-enzymatic activities (76.9, 72.8, 93.0 and 100% for collagenase, elastase, tyrosinase and hyaluronidase, respectively) for their use in skin whitening and anti-aging products. Thus, our preliminary study suggests that Icelandic Alaria esculenta-based extracts produced by PEF could be used as potential ingredients for natural cosmetic and cosmeceutical formulations.


Assuntos
Antioxidantes/farmacologia , Produtos Biológicos/química , Cosmecêuticos/química , Extratos Vegetais/farmacologia , Alga Marinha , Antioxidantes/química , Organismos Aquáticos , Humanos , Islândia , Extratos Vegetais/química
16.
J Drugs Dermatol ; 20(12): 1314-1321, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-34898162

RESUMO

OBJECTIVE: The dermal-epidermal junction (DEJ), composed of rare proteins, plays a significant role in facial skin aging. A newly enhanced multi-ingredient anti-aging facial moisturizer (MFM) and eye cream (MEC) were formulated to target DEJ-related aging. The objective of this study is to assess the efficacy and tolerability of a dual-product regimen MFM and MEC as a treatment in improving intrinsically and extrinsically aged facial and periorbital skin. METHOD: Forty-two female subjects, 42 to 65 years, Fitzpatrick skin type I–VI, with mild to moderate droopy eyelids, moderate crow’s feet wrinkles, and moderate global photodamage completed this institutional review board (IRB)-approved study. Subjects applied the MFM and MEC twice-daily for 12 weeks. Clinical grading of efficacy and tolerability parameters, VISIA®-CR imaging, image analysis of wrinkles, skin pH, Tewameter, and pinch recoil measurements were performed at baseline, weeks 4, 8, and 12. Optical coherence tomography (OCT) imaging was performed at baseline and week 12. RESULTS: Statistically significant improvement was shown in both clinically graded parameters and bio-instrumentational analyses at all time points. Both products were well tolerated by subjects. CONCLUSION: This IRB-approved clinical study demonstrated effectiveness in improving intrinsic and extrinsic signs of the global face and periorbital eye area aging after twelve weeks of twice-daily application. J Drugs Dermatol. 2021;20(12):1314-1321. doi:10.36849/JDD.6355.


Assuntos
Cosmecêuticos , Envelhecimento da Pele , Administração Cutânea , Idoso , Face , Feminino , Humanos , Pele , Resultado do Tratamento
17.
Recent Adv Antiinfect Drug Discov ; 16(3): 196-208, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34844552

RESUMO

BACKGROUND: The prevalence and scope of dermatological illness differ from region to region. Based upon type and severity, the conditions may vary from superficial to deep systemic skin infections. Niacinamide, an amide analog of vitamin B3 which was conventionally utilized as a food supplement, is now explored for the management of skin disorders. Being a powerhouse on its own, it is not stored inside the body naturally and has to be acquired from external sources. Areas Covered: This review is an attempt to disclose the physiology, pharmacology, and highlight the dermatological potentials of niacinamide, discussing its pharmacological mechanisms, varied commercially available treatments, and novel approaches, i.e., in research and patented formulations. RESULTS: Niacinamide has been verified in treating almost every skin disorder, viz. aging, hyperpigmentation, acne, psoriasis, pruritus, dermatitis, fungal infections, epidermal melasma, non-melanoma skin cancer, etc. It has been reported to possess numerous properties, for instance, anti-inflammatory, antimicrobial, antioxidant, antipruritic, and anticancer, which makes it an ideal ingredient for varied dermal therapies. Long term use of niacinamide, regardless of the skin type, paves the way for new skin cells, making skin healthier, brighter, and hydrated. CONCLUSION: Niacinamide possesses a variety of positive characteristics in the field of dermatology. Novel approaches are warranted over current treatments which could bypass the above shortcomings and form an effective and stable system. Hence, niacinamide has the potential to become an individual and a productive component with wide future scope.


Assuntos
Acne Vulgar , Cosmecêuticos , Dermatopatias , Aptidão , Humanos , Niacinamida/uso terapêutico
18.
Mar Drugs ; 19(10)2021 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-34677451

RESUMO

The interest in seaweeds for cosmetic, cosmeceutics, and nutricosmetics is increasing based on the demand for natural ingredients. Seaweeds offer advantages in relation to their renewable character, wide distribution, and the richness and versatility of their valuable bioactive compounds, which can be used as ingredients, as additives, and as active agents in the formulation of skin care products. Bioactive compounds, such as polyphenols, polysaccharides, proteins, peptides, amino acids, lipids, vitamins, and minerals, are responsible for the biological properties associated with seaweeds. Seaweed fractions can also offer technical features, such as thickening, gelling, emulsifying, texturizing, or moistening to develop cohesive matrices. Furthermore, the possibility of valorizing industrial waste streams and algal blooms makes them an attractive, low cost, raw and renewable material. This review presents an updated summary of the activities of different seaweed compounds and fractions based on scientific and patent literature.


Assuntos
Alga Marinha , Animais , Organismos Aquáticos , Produtos Biológicos , Cosmecêuticos , Cosméticos
19.
J Cosmet Dermatol ; 20(12): 3818-3828, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34510691

RESUMO

BACKGROUND: The qualified and paradigm jump in the formulation and production of cosmeceuticals refer in some way to the great revolution in nanotechnology. Nowadays, the industry of nano-formulated cosmeceuticals plays a significant and essential role in the evolution and growth of the pharmaceutical industries. This review manuscript focuses on the use of nanocarriers in delivering the cosmetic agents into the target area such as skin, hair, and nails. METHODS: Many steps were performed in the preparation of this review including identification of different classes of nanocarriers for delivery of nanocosmeceuticals, literature survey of relevantstudies regarding the applications of nanotechnology in cosmeceuticals and their toxicological effects. RESULTS: When nanoparticles introduced in the cosmetic industry, the quality and the elegance of the final products were raised significantly. Sadly, this revolution is accompanied by many health hazards as these tiny molecules can penetrate intact skin barriers and cause undesired effects. Cosmeceuticals with nanotechnology include sunscreens, hair cleansing products, nail products, and agents fighting fine lines. CONCLUSIONS: The expansion and growth of the cosmetic industry and the introduction of nanotechnology in cosmeceuticals industry necessitates the urgent need for scientific research investigating their efficacy, safety profile and use.


Assuntos
Cosmecêuticos , Cosméticos , Nanopartículas , Humanos , Nanotecnologia , Pele
20.
Eur J Pharm Sci ; 167: 106010, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-34537374

RESUMO

Biomolecular approaches for synthesis of inorganic nanoparticle are very popular among researchers and exhibit significant shape-directing morphologies in classified condition. The proteins are the most abundant macromolecules and employed for the hybrid synthesis as well as shape-directing agent. The present study is designed to investigate the potential role of a plant protein 'zein' to synthesize hybrid TiO2 nanoparticles. This versatile amphiphilic protein paves a unique path towards shape directing synthesis and act as template in the biomineralization process. The structural changes occurred in protein structure is thoroughly characterized using the circular dichroism (CD) and FTIR spectroscopy. UV, XPS and HRTEM analysis confirms the presence of zein on the nanoparticle surface. The proposed approach provides finely engineered nano-cuboidal (22.75±5.07 nm) geometry with homogenous dispersion, curved edged cuboids (403.51±0.05 nm) and spherical (97.85±0.62 nm) shaped from different modification, as evidenced by TEM. We also discussed in-vitro method for the detection of antimicrobial activity of nanocuboids against acne causing microorganisms such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Streptococcus agalactiae. Our results demonstrate that hybrid nanocuboids could be an efficient green material and provide cognitive antimicrobial evidence that could be deployed for cosmeceutical application.


Assuntos
Cosmecêuticos , Nanopartículas Metálicas , Zeína , Antibacterianos/farmacologia , Testes de Sensibilidade Microbiana , Titânio , Difração de Raios X
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