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1.
Zhongguo Zhong Yao Za Zhi ; 46(20): 5218-5225, 2021 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-34738422

RESUMO

Evodiamine, a bioactive indole alkaloid from Evodia rutaecarpa, E. rutaecarpa var. officinalis, or E. rutaecarpa var. bodinieri, has been extensively investigated due to its pharmacological activities in recent years. At present, evodiamine is proved to significantly suppress the proliferation of a variety of cancer cells and mediate cell processes such as cell cycle arrest and cell migration. In addition, evodiamine displays significant pharmacological activities against cardiovascular diseases(hyperlipidemia, etc.), and tinea manus and pedis. Recently, evodiamine has been found to have potential toxic effects, such as hepatotoxicity, nephrotoxicity, and cardiotoxicity. However, the pharmacological and toxicological mechanism of evodiamine is not clear, and its toxicity in vitro and in vivo has been rarely reported. Therefore, this study reviewed the pharmacological and toxicological articles of evodiamine in recent years, aiming at providing new ideas and references for future research.


Assuntos
Evodia , Dermatoses da Mão , Humanos , Extratos Vegetais , Quinazolinas/toxicidade , Tinha
2.
Dermatol Clin ; 39(4): 555-568, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34556245

RESUMO

The recent coronavirus disease 2019 (COVID-19) pandemic has led to the dramatic increase in use of personal protective equipment (PPE) among health care providers and the general public. Herein the authors discuss the various occupational dermatoses including allergic and irritant contact dermatitis, acne, seborrheic dermatitis, and rosacea related to frequent handwashing, disinfecting of surfaces, and prolonged wear of various PPE including face masks, gloves, and gowns. The authors provide an overview of published PPE-associated occupational dermatoses during the COVID-19 pandemic and also discuss prevention strategies and treatment options to help patients with these complaints.


Assuntos
COVID-19/epidemiologia , Dermatite Alérgica de Contato/epidemiologia , Dermatite Ocupacional/epidemiologia , Exposição Ocupacional/efeitos adversos , Equipamento de Proteção Individual/efeitos adversos , COVID-19/prevenção & controle , Dermatite Alérgica de Contato/diagnóstico , Dermatite Irritante/etiologia , Dermatite Ocupacional/diagnóstico , Dermatoses Faciais/etiologia , Luvas Protetoras/efeitos adversos , Dermatoses da Mão/etiologia , Humanos
3.
J Am Board Fam Med ; 34(5): 888-890, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34535513

RESUMO

Increased attention towards infection control measures during the COVID-19 pandemic have brought to light the dermatological consequences of intensified hand hygiene measures. Healthcare workers are inherently at an increased risk of developing both allergic and irritant contact dermatitis. Individuals with a history of atopy are especially vulnerable given their impaired native skin barriers and increased sensitivities at baseline. Examination gloves not only induce contact allergies from manufacturing chemicals, but also serve as an occlusive catalyst for facilitating contact sensitization and irritant dermatitis. Similarly, handwashing practices with soap and alcohol-based hand rubs (ABHRs) undermine the natural skin barriers with increasing frequency of use. We highlight clinical pearls for the frontline healthcare worker experiencing COVID-19 surges and offer practical measures to minimize the development of hand-based dermatitis.


Assuntos
COVID-19 , Dermatite Ocupacional , Dermatoses da Mão , Higiene das Mãos , Dermatite Ocupacional/epidemiologia , Dermatoses da Mão/epidemiologia , Humanos , Pandemias , SARS-CoV-2
4.
Acta Derm Venereol ; 101(9): adv00543, 2021 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-34427318

RESUMO

The COVID-19 pandemic has led to enhanced hygiene procedures and use of personal protective equipment, but also to increased attention to occupational skin disease in healthcare workers. The occurrence of hand and facial skin disease in > 5,000 Swedish healthcare workers was investigated in a questionnaire survey. Levels of skin exposure related to hygiene procedures and personal protective equipment were recorded. Caring for patients with COVID-19 entailed higher levels of wet work and face mask exposures, and was associated with higher 1-year prevalence of both hand eczema (36%) and facial skin disease (32%) compared with not being directly engaged in COVID-19 care (28% and 22%, respectively). Acne and eczema were the most common facial skin diseases; for both, a dose-dependent association with face mask use was found. Dose-dependent associations could be shown between hand eczema and exposure to soap and gloves, but not to alcohol-based hand disinfectants.


Assuntos
COVID-19 , Dermatite Ocupacional , Eczema , Dermatoses da Mão , Estudos Transversais , Dermatite Ocupacional/diagnóstico , Dermatite Ocupacional/epidemiologia , Eczema/diagnóstico , Eczema/epidemiologia , Dermatoses da Mão/diagnóstico , Dermatoses da Mão/epidemiologia , Pessoal de Saúde , Humanos , Pandemias , SARS-CoV-2
5.
J Investig Med High Impact Case Rep ; 9: 23247096211037458, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34334014

RESUMO

In this article, we describe a case of neutrophilic dermatosis of the dorsal hands (NDDH) complicated with myelodysplastic syndrome and chronic active hepatitis C infection. NDDH was first suggested by Galaria et al in 2000. After comparing features of NDDH with Sweet syndrome in terms of encompassing clinical, laboratory, and histological characteristics, it can be concluded that "distributional or localized variant" of Sweet syndrome is classified as NDDH. Early diagnosis and treatment can improve prognosis. Systemic glucocorticoids are the mainstay of treatment.


Assuntos
Dermatoses da Mão , Hepatite C Crônica , Síndromes Mielodisplásicas , Síndrome de Sweet , Glucocorticoides/uso terapêutico , Hepatite C Crônica/complicações , Hepatite C Crônica/tratamento farmacológico , Humanos , Síndromes Mielodisplásicas/complicações , Síndromes Mielodisplásicas/diagnóstico , Síndrome de Sweet/diagnóstico
6.
Med Lav ; 112(4): 320-326, 2021 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-34446683

RESUMO

BACKGROUND: Occupational hand dermatitis (OHD) is a skin disease occurring on employees' hands in certain jobs. Little is known about prevalence, incidence and characteristics of this adverse skin reaction and its associated risk factors during COVID-19 pandemic. To evaluate both prevalence and incidence of OHD and associated risk factors in Italian clinicians. METHODS: A cross-sectional study was performed using a self-report questionnaire. RESULTS: Two hundred and thirty clinicians responded to the survey and 82% of responders did not report previous OHD history before the COVID-19 pandemic. Daily use of gloves was reported by 80% of responders. OHD prevalence was 18%, while incidence was 80%. We found a protective effect on symptom occurrence for vinyl/nitrile gloves if the time with gloves was ≥ 6 hours per day. CONCLUSIONS: This survey reveals a high OHD incidence in an Italian population of clinicians. Furthermore, wearing vinyl/nitrile gloves for at least 6 hours a day had a protective effect on symptom onset.


Assuntos
COVID-19 , Dermatite Ocupacional , Dermatoses da Mão , Estudos Transversais , Dermatite Ocupacional/epidemiologia , Dermatite Ocupacional/etiologia , Luvas Protetoras , Dermatoses da Mão/epidemiologia , Dermatoses da Mão/etiologia , Hospitais , Humanos , Pandemias , SARS-CoV-2 , Inquéritos e Questionários
7.
Eur J Dermatol ; 31(3): 392-395, 2021 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-34309523

RESUMO

BACKGROUND: Hand hygiene measures in the general population and in health care workers have increased considerably since the outbreak of the COVID-19 pandemic. OBJECTIVES: To investigate the prevalence and symptoms of hand eczema, as well as hygiene measures and concepts of care, in German health care workers. MATERIALS & METHODS: This was an observational questionnaire study to investigate hygiene and skin care habits, as well as the prevalence and symptoms of hand eczema in 66 nurses and doctors of our dermatology department before and during the SARS-CoV-2 pandemic. RESULTS: Hand washing and hand disinfection procedures increased significantly during the COVID-19 pandemic. Self-diagnosed hand eczema was reported by 33% of the participants, with a median duration of 14 days. The majority of staff currently affected by hand eczema were free of eczema a month previously (82%) and would treat their skin condition with emollients (77%). Erythema, scaling, burning and fissures were reported by 66.1% of the participants and were classified as predominant signs of toxic-irritant hand dermatitis rather than contact allergy. CONCLUSION: Overall, the SARS-CoV-2 pandemic has led to a significant increase in the incidence of signs of irritant hand eczema despite intensified emollient use as a preventive measure. Awareness of the prevalence of hand eczema in health care workers in Germany during the COVID-19 pandemic should be raised, and preventive measures should be intensified.


Assuntos
COVID-19/prevenção & controle , Dermatite Irritante/epidemiologia , Dermatite Ocupacional/epidemiologia , Dermatoses da Mão/epidemiologia , Desinfecção das Mãos , Corpo Clínico Hospitalar , Recursos Humanos de Enfermagem no Hospital , Alemanha/epidemiologia , Humanos , Pandemias , Prevalência , SARS-CoV-2
9.
Acta Derm Venereol ; 101(8): adv00515, 2021 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-34219178

RESUMO

Hand eczema is frequently colonized with Staphylococcus aureus. Some patients with hand eczema wear occlusive gloves regularly; however, the effect of this on the density of S. aureus is unexplored. The aim of this study is to examine the effect of occlusive gloves on the density of S. aureus sampled from the hands of patients with hand eczema. In an experimental set-up, patients with moderate-to-severe hand eczema wore an occlusive glove on one hand for 4 h with a 30-min break. Bacterial swabs were collected from the most severe eczema lesion on the hand before and immediately after glove exposure. S. aureus colony-forming units were counted and log-transformations used for comparison of before- and after-values. Among 30 patients, 19 (63%) were colonized with S. aureus. After glove occlusion S. aureus colony-forming units increased by a factor of 1.72 (p < 0.01). In conclusion, the density of sampled S. aureus on eczematous skin after prolonged wearing of occlusive gloves is greatly increased.


Assuntos
Eczema , Dermatoses da Mão , Infecções Estafilocócicas , Eczema/diagnóstico , Luvas Protetoras , Mãos , Dermatoses da Mão/diagnóstico , Humanos , Infecções Estafilocócicas/diagnóstico , Staphylococcus aureus
10.
Ned Tijdschr Tandheelkd ; 128(6): 323-330, 2021 Jun.
Artigo em Holandês | MEDLINE | ID: mdl-34096932

RESUMO

In recent decades, hand eczema has been seen more frequently in oral care practices. Hand eczema is a difficult problem, especially since the start of the current COVID-19-pandemic, and can lead to absence due to illness at work. The main trio in the development of eczema is predisposition (atopy), irritation and allergy. Irritative contact dermatitis is caused by damage to the skin barrier. In dentistry, this is often caused by frequent contact with water, soaps, disinfectants and the use of gloves. The cause of allergic contact dermatitis is related to the use of various materials in oral care practice, such as acrylates, rubber and rubber additives. Essential measures are very important in oral care practice to prevent hand eczema. Various measures are key: adequate skin care with liniments, good skin protection with proper gloves and no-touch techniques. Knowledge of possible allergens and adequate hand hygiene and hand care are crucial to minimize the risk of chronic eczema.


Assuntos
COVID-19 , Dermatite Ocupacional , Dermatoses da Mão , Saúde do Trabalhador , Dermatite Ocupacional/epidemiologia , Dermatite Ocupacional/etiologia , Dermatite Ocupacional/prevenção & controle , Dermatoses da Mão/epidemiologia , Dermatoses da Mão/etiologia , Dermatoses da Mão/prevenção & controle , Humanos , SARS-CoV-2
11.
Artigo em Inglês | MEDLINE | ID: mdl-34169709

RESUMO

Fish tank granuloma is a rare skin infection caused by Mycobacterium marinum. It occurs after exposure of skin abrasions to contaminated water or infected fish. The majority of M. marinum infections today are fish tank-related. The most common presentation is a solitary nodule, often with sporotrichoid spread. Other presentations do not occur often. The diagnosis is often delayed because of lack of suspicion, nonspecific histopathological findings, and frequently unsuccessful cultivation. Here we present the case of a 37-year-old male with M. marinum skin infection, presenting as erythematous scaling plaques. Because the initial results of laboratory and histopathological examinations were negative for a fungal infection or nontuberculous mycobacteria, the patient was treated empirically with several systemic antibiotics and antifungals without any success. Finally, the diagnosis of fish tank granuloma was confirmed 3 months after the initial presentation of the patient. After the introduction of treatment with rifampicin and clarithromycin, complete clinical remission was observed after 6 months of therapy.


Assuntos
Infecções por Mycobacterium não Tuberculosas , Mycobacterium marinum , Dermatopatias Bacterianas , Adulto , Animais , Antibacterianos/uso terapêutico , Dermatoses da Mão , Humanos , Masculino , Infecções por Mycobacterium não Tuberculosas/diagnóstico , Infecções por Mycobacterium não Tuberculosas/tratamento farmacológico , Dermatopatias Bacterianas/diagnóstico , Dermatopatias Bacterianas/tratamento farmacológico , Tinha
13.
J Prim Care Community Health ; 12: 21501327211018013, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34009056

RESUMO

PURPOSE: This study aimed to explore the prevalence of and possible risk factors for hand eczema with respect to the dissemination of information about new hand hygiene habits to protect against ongoing COVID-19 cross-transmission. The authors conducted a survey among health care workers (HCWs) and non-HCW populations in Khon Kaen, Thailand. RESULTS: A total of 805 participants participated. The prevalence of hand eczema in the study population was 20.87%. There were several risk factors, including working as a HCW, having a history of previous hand eczema, having underlying atopic dermatitis, wearing gloves in everyday life, and washing hands frequently (more than 10 times/day). Hand hygiene with alcohol-based products was shown to be a risk factor for hand eczema, (OR (95% CI) 1.86 (1.03-3.35), P = .04). CONCLUSION: In terms of hand eczema prevention, we suggest that the use of alcohol-based products should be discontinued if other handwashing methods are available. The following factors increase the risk of hand eczema: being a HCW, having previous hand eczema, and having underlying atopic dermatitis. Proper strategies in terms of hand eczema prevention should be addressed, especially in this group, since we need to continue performing hand hygiene during the ongoing COVID-19 pandemic.


Assuntos
COVID-19 , Eczema , Dermatoses da Mão , Higiene das Mãos , Eczema/epidemiologia , Eczema/etiologia , Eczema/prevenção & controle , Hábitos , Dermatoses da Mão/epidemiologia , Dermatoses da Mão/etiologia , Dermatoses da Mão/prevenção & controle , Humanos , Pandemias , Prevalência , SARS-CoV-2 , Tailândia/epidemiologia
14.
An Bras Dermatol ; 96(4): 477-481, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34016479

RESUMO

Herpetic whitlow is a viral infection of the fingers caused by the herpes simplex virus. The disease has a bimodal age distribution, affecting children under 10 years of age and young adults between 20 and 30 years old. It can be easily mistaken for panaritium or bacterial cellulitis. In patients with AIDS, atypical, chronic and recurrent ulcerated lesions occur. The Tzanck test allows a quick and low-cost diagnosis of herpes simplex virus infection. The authors report the case of a child with AIDS with painful finger ulcers in which the diagnosis was confirmed by the Tzanck test.


Assuntos
Síndrome de Imunodeficiência Adquirida , Dermatoses da Mão , Herpes Simples , Paroniquia , Síndrome de Imunodeficiência Adquirida/complicações , Criança , Dedos , Dermatoses da Mão/diagnóstico , Herpes Simples/diagnóstico , Humanos , Adulto Jovem
15.
Clin Dermatol ; 39(1): 23-32, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33972048

RESUMO

The first cases of coronavirus disease 2019 (COVID-19) in Iran were detected on February 19, 2020. Soon the entire country was hit with the virus. Although dermatologists were not immediately the frontline health care workers, all aspects of their practice were drastically affected. Adapting to this unprecedented crisis required urgent appropriate responses. With preventive measures and conserving health care resources being the most essential priorities, dermatologists, as an integral part of the health system, needed to adapt their practices according to the latest guidelines. The spectrum of the challenges encompassed education, teledermatology, lasers, and other dermatologic procedures, as well as management of patients who were immunosuppressed or developed drug reactions and, most importantly, the newly revealed cutaneous signs of COVID-19. These challenges have paved the way for new horizons in dermatology.


Assuntos
COVID-19/epidemiologia , COVID-19/prevenção & controle , Dermatologia/normas , Hospitais Universitários , Dermatopatias/etiologia , Dermatopatias/terapia , COVID-19/complicações , COVID-19/tratamento farmacológico , Técnicas Cosméticas , Dermatite/etiologia , Procedimentos Cirúrgicos Dermatológicos , Dermatologia/educação , Dermatologia/métodos , Dermoscopia , Erupção por Droga/etiologia , Dermatoses da Mão/etiologia , Desinfecção das Mãos , Humanos , Internato e Residência , Irã (Geográfico)/epidemiologia , Terapia a Laser , Equipamento de Proteção Individual/efeitos adversos , Fototerapia , Guias de Prática Clínica como Assunto , Prática Privada , SARS-CoV-2 , Dermatopatias/tratamento farmacológico , Telemedicina
16.
Clin Dermatol ; 39(1): 84-91, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33972057

RESUMO

The emergence of the coronavirus disease 2019 (COVID-19) worldwide pandemic has been associated with a new constellation of cutaneous features in children. Among the unusual dermatologic presentations are the so-called COVID toes, inflammatory nodules of the feet and toes, sometimes involving the hands and fingers. These lesions mimic acral pernio, the synonym being chilblains. Unlike adult patients with COVID toes, children are less likely to manifest symptomatic COVID-19. Although a few studies have found some linkage to COVID-19 through the serum IgA or IgG severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, other studies have no demonstrable linkage suggesting that barefoot children in cold weather develop such lesions. It appears that the chilblain-like lesions related to the period of the COVID-19 pandemic may reflect a brisk immune response portending a good prognosis and perhaps some form of innate immunity. The possible need to screen for coagulopathy is unclear, but this has been suggested in one report. Until we fully understand the pattern of immune response to COVID-19, questions may persist as to how disease manifestations are linked to SARS-CoV-2 exposures.


Assuntos
COVID-19/complicações , Pérnio/virologia , Dermatoses do Pé/virologia , Dermatoses da Mão/virologia , Adolescente , Pérnio/imunologia , Criança , Pré-Escolar , Dedos , Dermatoses do Pé/imunologia , Dermatoses da Mão/imunologia , Humanos , Lactente , Recém-Nascido , SARS-CoV-2 , Dedos do Pé
17.
J Dtsch Dermatol Ges ; 19(5): 720-741, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33938626

RESUMO

Occupational dermatoses are among the most common occupational diseases, with BK 5101 accounting for the largest proportion. Historically, the latter was also the most frequently reported group of occupational diseases within the working age population. More than 80,000 suspected cases of occupational diseases were notified in 2019, of which 19,883 related to BK 5101. In Germany, work-related hand eczema accounts for 90 % of all BK 5101 diseases, and consists mainly of contact eczema. Especially young people working in the hairdressing sector, health care, metal, food or construction industries belong to the high-risk group. Diagnosis, therapy and prevention of BK 5101 play an important role, since advanced skin diseases are usually accompanied by a poor prognosis and long periods of inability to work, which can have considerable socio-economic consequences. On January 1st , 2021, with the "Seventh Act amending the Fourth Book of the German Social Code (SGB) and other Laws", an amendment to the Occupational Diseases Law came into force, with which the obligation to cease work was abolished, thereby fulfilling a decades-long requirement for recognition of BK 5101. As of this year, only the "severe or repeated recurrences" of a skin disease remain as a criterion for the occurrence of an insured event, which will likely result in an increased number of notifications and acknowledged cases of occupational skin diseases.


Assuntos
Dermatite de Contato , Dermatite Ocupacional , Eczema , Dermatoses da Mão , Doenças Profissionais , Dermatopatias , Adolescente , Dermatite Ocupacional/diagnóstico , Alemanha , Humanos , Doenças Profissionais/diagnóstico , Doenças Profissionais/epidemiologia , Dermatopatias/diagnóstico , Dermatopatias/epidemiologia , Dermatopatias/terapia
18.
J Dtsch Dermatol Ges ; 19(7): 993-1001, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33973357

RESUMO

BACKGROUND AND OBJECTIVE: Dermatophyte infections of the skin and nails are common worldwide and vary between geographical areas and over time. The aim of this study was to determine the epidemiological profile of dermatophytes in Germany with a focus on comparing children with adults. PATIENTS AND METHODS: In this retrospective multicenter study, mycological dermatophyte culture results in the period 01/2014 to 12/2016 were analyzed according to identified pathogen, age and gender of patients, and type of disease. RESULTS: Of 1,136 infections (children: n = 88, adults: n = 1,048), 50.8 % were clinically classified as onychomycosis, followed by tinea pedis (34.6 %), tinea corporis (16.2 %), tinea manus (16.2 %), tinea capitis (2.5 %), and tinea faciei (1.2 %). The most frequent pathogen was Trichophyton (T.) rubrum (78.6 %), followed by T. interdigitale (14.3 %), T. benhamiae (3.2 %), T. mentagrophytes (2.1 %), and Microsporum canis (1.7 %). The fungal spectrum differed particularly in tinea corporis and tinea capitis between children and adults with a more diverse pathogen spectrum in children. Trichophyton tonsurans was rarely identified as cause for tinea corporis (2.7 %) or tinea capitis (3.3 %). CONCLUSIONS: Differences in pathogens and frequency of fungal infections between age groups should be considered for optimal selection of the appropriate therapeutic regimen.


Assuntos
Arthrodermataceae , Dermatomicoses , Adulto , Criança , Dermatomicoses/diagnóstico , Dermatomicoses/epidemiologia , Alemanha/epidemiologia , Dermatoses da Mão , Humanos , Microsporum , Estudos Retrospectivos , Tinha , Trichophyton
20.
Hautarzt ; 72(6): 502-508, 2021 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-33948675

RESUMO

Occupational dermatology has become a vibrant and interesting specialty, particularly in recent years. This includes more than hand eczema (HE). The increasing prevalence of atopic dermatitis (AD) has led to an increase of atopic hand eczema which can be worsened in certain occupations. New systemic therapies have improved the range of treatments for HE. The current guideline on hand eczema includes a variety of topical and systemic therapies. Nevertheless, in daily occupational dermatological practice, there are still chronic cases, especially vesicular hand eczema. They can often not be assigned to a clear cause, which is often a problem for those who are affected. In addition, co-factors such as chronic infectious comorbidities and psychological factors/illnesses must be considered. We present challenges in occupational dermatology by reporting special cases.


Assuntos
Dermatite Atópica , Dermatite Ocupacional , Dermatologia , Eczema , Dermatoses da Mão , Dermatite Atópica/diagnóstico , Dermatite Atópica/epidemiologia , Dermatite Ocupacional/diagnóstico , Dermatite Ocupacional/epidemiologia , Dermatoses da Mão/diagnóstico , Dermatoses da Mão/epidemiologia , Dermatoses da Mão/terapia , Humanos
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