Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 2.220
Filtrar
1.
Clin Dermatol ; 39(2): 229-232, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34272015

RESUMO

Cutaneous dermal mucinoses are a group of conditions characterized by abnormal deposition of mucin (hyaluronic acid and sulfated glycosaminoglycans) in the dermis. They can be classified either as localized or generalized forms and occur primarily or secondarily to systemic disorders. Obesity-associated lymphedematous mucinosis and pretibial stasis mucinosis are uncommon and relatively newly recognized disorders occurring in obese patients or in patients with venous insufficiency. Clinically, patients present with papules and nodules progressing to plaques and arising in an erythematous and edematous basis on the legs, especially the shins. Histopathologic examination indicates mucin deposition in the superficial portion of the dermis, angioplasia with an increase in small blood and/or lymphatic vessels, vertically running vessels, slight fibrosis, and no inflammation. Laboratory workup and histopathologic testing are helpful in differentiating these entities from pretibial myxedema (thyroid dermopathy), which represents the main differential diagnosis. Obesity-associated lymphedematous mucinosis and stasis mucinosis are not different entities but belong to a spectrum of mucinoses secondary to an increased body mass index, chronic lymphedema, and/or chronic venous insufficiency.


Assuntos
Dermatoses da Perna , Linfedema , Mucinoses , Mixedema , Humanos , Linfedema/complicações , Linfedema/diagnóstico , Mucinoses/complicações , Mucinoses/diagnóstico , Obesidade/complicações
3.
Clin Exp Dermatol ; 46(6): 1082-1085, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-33864685

RESUMO

Pyoderma gangrenosum (PG) is a rare, debilitating, inflammatory skin disease associated with a variety of systemic diseases. Because of its rarity, PG is treated with miscellaneous immunosuppressive agents as there is no US Food and Drug Administration-approved standardized treatment approach. We present four patients with PG treated with tofacitinib in the context of the six existing cases in the literature. Tofacitinib appeared to be beneficial in the small sample of patients (n = 10) who failed an average of four other systemic therapies. The majority of patients had classic PG located on the legs (80%, 8/10), while 20% of cases (2/10) were peristomal. The most common comorbidity was inflammatory bowel disease (78%, 7/9). There were no negative treatment results and 40% (4/10) of patients had complete healing of their ulcers, while the other 60% (6/10) had marked clinical improvement. From our observation, tofacitinib appears to be a promising steroid-sparing adjuvant treatment in patients with refractory PG who have failed on other systemic therapies.


Assuntos
Fármacos Dermatológicos/uso terapêutico , Piperidinas/uso terapêutico , Inibidores de Proteínas Quinases/uso terapêutico , Pioderma Gangrenoso/tratamento farmacológico , Pirimidinas/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Imunossupressores/uso terapêutico , Doenças Inflamatórias Intestinais/complicações , Dermatoses da Perna/tratamento farmacológico , Dermatoses da Perna/patologia , Masculino , Pessoa de Meia-Idade , Pioderma Gangrenoso/complicações , Pioderma Gangrenoso/patologia , Estomas Cirúrgicos/patologia , Resultado do Tratamento
4.
Clin Exp Dermatol ; 46(6): 1016-1022, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-33882159

RESUMO

Dermatomyositis (DM) is an autoimmune connective tissue disease that is included in the idiopathic inflammatory myopathies. Cutaneous manifestations are a prominent part of the condition: some skin signs in DM are common to most patients, while other signs are encountered infrequently. A number of features are pathognomic for DM. The demonstration of myositis-specific antibodies (MSAs) in DM has extended the ability to define phenotypic subgroups. It appears that the presence of certain MSAs confers susceptibility to specific clinical features, an association which reveals a serotype-phenotype relationship. In this review article we have provided a detailed summary of common and under-recognized cutaneous manifestations of DM.


Assuntos
Dermatomiosite/patologia , Exantema/patologia , Calcinose/etiologia , Dermatomiosite/complicações , Dermatoses Faciais/patologia , Dermatoses da Mão/patologia , Humanos , Dermatoses da Perna/patologia , Paniculite/etiologia , Dermatoses do Couro Cabeludo/patologia , Tronco/patologia
5.
Contact Dermatitis ; 84(6): 407-418, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33533485

RESUMO

BACKGROUND: In about half of the patients reacting positive to fragrance mix I (FM I), breakdown testing remains negative. This raises the question of whether the reaction to FM I is false-positive, or the breakdown test is false-negative. OBJECTIVES: To identify characteristics and sensitization patterns of patients positive to FM I, but not to its fragrance constituents. PATIENTS AND METHODS: Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK) between 2005 and 2019. Three patient groups were defined according to their reaction pattern: Group I, FM I positive and ≥1 single fragrance positive in the breakdown test (n = 1912); Group II, FM I positive and breakdown test negative (n = 1318); Group III, FM I negative (n = 19 790). RESULTS: Regarding the pattern of concomitant reactions to other fragrances, Group II had an intermediate position between Group I and Group III. In other respects (age and sex distribution, frequency of sensitization to non-fragrance baseline series allergens), Group II rather resembled Group I. CONCLUSIONS: Not every positive reaction to FM I in patients with negative breakdown tests is false-positive. There may be false-negative reactions to the single fragrance components when patch tested at 1% pet. Raising patch concentrations of some single fragrances is recommended.


Assuntos
Dermatite Alérgica de Contato/diagnóstico , Odorantes , Testes do Emplastro/métodos , Adulto , Dermatite Atópica/diagnóstico , Dermatite Ocupacional/diagnóstico , Reações Falso-Negativas , Reações Falso-Positivas , Dermatoses da Mão/diagnóstico , Humanos , Dermatoses da Perna/diagnóstico , Masculino , Estudos Retrospectivos
6.
Contact Dermatitis ; 84(6): 395-406, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33534191

RESUMO

BACKGROUND: Fragrances constitute the second most frequent cause of allergic contact dermatitis in Spain. OBJECTIVES: To determine the rate of sensitization to the individual fragrances of fragrance mix (FM) I and FM II for each of the demographic and clinical factors included in the MOAHLFA (male, occupational dermatitis, atopic dermatitis, hand dermatitis, leg dermatitis, facial dermatitis, age) index. METHODS: We conducted a 5-year retrospective study in 23 Spanish centres. We identified the patients who had undergone patch testing with a specific fragrance series after reacting positively to fragrance markers in a baseline series. We obtained the MOAHLFA index items in this population, then calculated for each demographic and clinical factor the frequencies of sensitization to the individual fragrances of FM I and FM II. RESULTS: A specific fragrance series was patch tested in 1013 patients. The most frequent allergens in men, women, children, and retired people were Evernia prunastri (16%), geraniol (16.6%), isoeugenol (17.9%), and geraniol (22.4%), respectively. Citral (20.5%) and hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) (14.5%) were the most common allergens in occupational eczemas and were also associated with a large proportion of hand and facial dermatitis. CONCLUSIONS: Frequency of sensitization to the individual fragrances of FM I and FM II varies with age, sex, affected body region, and history of occupational or atopic dermatitis.


Assuntos
Dermatite Alérgica de Contato/epidemiologia , Dermatite Alérgica de Contato/etiologia , Odorantes , Adulto , Idade de Início , Criança , Dermatite Atópica/epidemiologia , Dermatite Atópica/etiologia , Dermatite Ocupacional/epidemiologia , Dermatite Ocupacional/etiologia , Dermatoses Faciais/epidemiologia , Dermatoses Faciais/etiologia , Feminino , Dermatoses da Mão/etiologia , Humanos , Dermatoses da Perna/epidemiologia , Dermatoses da Perna/etiologia , Masculino , Testes do Emplastro/métodos , Estudos Retrospectivos , Espanha/epidemiologia
12.
Acta Dermatovenerol Alp Pannonica Adriat ; 29(3): 157-159, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32975304

RESUMO

Pretibial pruritic papular dermatitis (PPPD) is a clinical entity first described in 2006. The etiology is uncertain; however, gentle chronic rubbing is likely to be the reason for the skin reaction. Pretibial pruritic lesions may reflect many different systemic diseases and dermatoses. We present a 61-year-old patient with a 2-year history of pruritic pretibial xerosis, keratotic erythematous to brownish papules, and excoriations. Differential diagnosis excluded papular mucinosis, myxoedema, stasis dermatitis, lichen simplex chronicus, prurigo nodularis, lichen amyloidosis, and lichen planus. Regarding clinical-histological correlation, we confirmed a diagnosis of PPPD.


Assuntos
Dermatoses da Perna/diagnóstico , Dermatoses da Perna/etiologia , Prurido/diagnóstico , Prurido/etiologia , Diagnóstico Diferencial , Feminino , Humanos , Dermatoses da Perna/terapia , Pessoa de Meia-Idade , Prurido/terapia
14.
Indian J Tuberc ; 67(3): 433-437, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32825889

RESUMO

Cutaneous tuberculosis occurs in 1-2% of world cases of tuberculosis and more common in tropical countries. It presents with different clinical forms. Unusual clinical presentations are not uncommon and awareness of these will help in suspecting and managing these patients successfully. Lupus pernio like lupus vulgaris, tuberculosis of glans penis and lichen scrofulosorum on the distal parts of limbs are presented here because of their unusual clinical presentation.


Assuntos
Dermatoses Faciais/patologia , Dermatoses da Perna/patologia , Lúpus Vulgar/patologia , Doenças do Pênis/patologia , Tuberculose Cutânea/patologia , Tuberculose dos Genitais Masculinos/patologia , Adulto , Antituberculosos/uso terapêutico , Dermatoses Faciais/diagnóstico , Dermatoses Faciais/tratamento farmacológico , Antebraço/patologia , Humanos , Dermatoses da Perna/diagnóstico , Dermatoses da Perna/tratamento farmacológico , Lúpus Vulgar/diagnóstico , Lúpus Vulgar/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Doenças do Pênis/diagnóstico , Doenças do Pênis/tratamento farmacológico , Tuberculose Cutânea/diagnóstico , Tuberculose Cutânea/tratamento farmacológico , Tuberculose dos Genitais Masculinos/diagnóstico , Tuberculose dos Genitais Masculinos/tratamento farmacológico
18.
Rev. clín. med. fam ; 13(2): 146-148, jun. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-199836

RESUMO

La púrpura pigmentosa de Schamberg (púrpura pigmentaria progresiva) es una dermatosis purpúrica pigmentaria. Suele localizarse en las extremidades inferiores bilateralmente. Es asintomática, aunque en ocasiones presentan prurito leve. El curso de la condición es típicamente crónico, con numerosas exacerbaciones y remisiones. También puede ocurrir una resolución espontánea. La biopsia es la prueba fundamental para su diagnóstico, mostrando capilaritis linfocítica


Schamberg's purpura pigmentosa (progressive pigmentary purpura) is a pigmentary purpuric dermatosis. It usually occurs bilaterally on lower limbs. It is asymptomatic, though it occasionally presents slight itching. The course of the disease is typically chronic, with numerous exacerbations and remissions. Spontaneous resolution may also occur. Biopsy is the crucial test for diagnosis, which shows lymphocytic capillaritis


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Púrpura/diagnóstico , Transtornos da Pigmentação/diagnóstico , Corticosteroides/uso terapêutico , Antibacterianos/uso terapêutico , Dermatoses da Perna/diagnóstico , Biópsia/métodos , Diagnóstico Diferencial
19.
An Bras Dermatol ; 95(4): 469-472, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32461007

RESUMO

Localized pretibial myxedema is a dermopathy whose treatment is a challenge in dermatology, occurring in 0.5-4% of patients with Graves' disease. This autoimmune thyroid condition stimulates the production of hyaluronic acid and glycosaminoglycans that are deposited particularly in the pretibial region. Clinically, it presents as a localized, circumscribed, and non-depressible infiltrate in plaques. Several treatment modalities have been proposed, and their results vary, with worse response observed in severe cases. This report presents the case of a patient with elephantiasic pretibial myxedema who was subjected to intralesional corticosteroid applications, resulting in an excellent and encouraging therapeutic response that was maintained.


Assuntos
Doença de Graves , Dermatoses da Perna , Mixedema , Corticosteroides , Feminino , Humanos , Pessoa de Meia-Idade , Triancinolona
20.
Pediatr Rheumatol Online J ; 18(1): 40, 2020 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-32448396

RESUMO

BACKGROUND: Henoch-Schönlein purpura (HSP) is the most common vasculitis of childhood. It has a characteristic rash described as palpable purpura that most frequently affects the distal lower extremities and buttocks. HSP rarely presents with bullous rash nor pulmonary nodules. CASE PRESENTATION: We present a novel case of a 12-years-old female with recurrent pediatric HSP with a combination of the rare manifestations of bullous rash and pulmonary nodules. She initially presented with the bullous rash, chest pain, cough, and abdominal pain. Patient was successfully treated with intravenous pulse corticosteroids followed by a high dose oral corticosteroid taper, with resolution of the bullous rash and pulmonary nodules. CONCLUSION: The rare manifestations of scarring bullous rash and pulmonary nodules can be presenting features of pediatric HSP, the combination of which has not been previously reported. The treatment of intravenous corticosteroid resolved patient's abdominal symptoms, rash and pulmonary nodules.


Assuntos
Nódulos Pulmonares Múltiplos/fisiopatologia , Púrpura de Schoenlein-Henoch/fisiopatologia , Dermatopatias Vesiculobolhosas/fisiopatologia , Biópsia por Agulha Fina , Líquido da Lavagem Broncoalveolar , Dor no Peito/tratamento farmacológico , Dor no Peito/fisiopatologia , Criança , Complemento C3 , Tosse , Feminino , Técnica Direta de Fluorescência para Anticorpo , Gabapentina/uso terapêutico , Glucocorticoides/uso terapêutico , Humanos , Biópsia Guiada por Imagem , Imunoglobulina A , Dermatoses da Perna/tratamento farmacológico , Dermatoses da Perna/patologia , Dermatoses da Perna/fisiopatologia , Nódulos Pulmonares Múltiplos/diagnóstico por imagem , Nódulos Pulmonares Múltiplos/tratamento farmacológico , Neuralgia/tratamento farmacológico , Neuralgia/fisiopatologia , Púrpura de Schoenlein-Henoch/diagnóstico por imagem , Púrpura de Schoenlein-Henoch/tratamento farmacológico , Púrpura de Schoenlein-Henoch/patologia , Recidiva , Dermatopatias Vesiculobolhosas/tratamento farmacológico , Dermatopatias Vesiculobolhosas/patologia , Tomografia Computadorizada por Raios X
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...