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1.
Rev Med Chil ; 145(8): 1067-1071, 2017 Aug.
Artigo em Espanhol | MEDLINE | ID: mdl-29189866

RESUMO

Saprochaete capitata (S. capitata) fungal sepsis is a severe condition with a clinical presentation that is similar to other yeast originated fungal sepsis. It is observed in patients with hematological malignancies such as acute myeloid leukemia and neutropenia. We report a 23 year old male presenting with cough, fever and malaise. A bone marrow biopsy led to the diagnosis of acute myeloid leukemia. During the first cycle of chemotherapy the patient presented fever: blood cultures were positive for Klebsiella pneumoniae. Despite antimicrobial treatment, fever persisted; a computed tomography showed a focal splenic lesion; a left exudative pleural effusion appeared. A Matrix Assisted Laser Desorption Ionization-Time of Flight mass spectrometry identified the presence of S. capitata. After multiple antifungal treatments and pleural cavity cleansing by means of videothoracoscopy and laparoscopic splenectomy, the infection resolved and the patient completed his chemotherapy.


Assuntos
Dipodascus/isolamento & purificação , Fungemia/cirurgia , Leucemia Mieloide Aguda/microbiologia , Antifúngicos/uso terapêutico , Drenagem/métodos , Fungemia/tratamento farmacológico , Fungemia/patologia , Humanos , Masculino , Pleurisia/microbiologia , Pleurisia/patologia , Esplenectomia/métodos , Esplenopatias/microbiologia , Esplenopatias/patologia , Esplenopatias/cirurgia , Resultado do Tratamento , Adulto Jovem
2.
Rev. méd. Chile ; 145(8): 1067-1071, ago. 2017. graf
Artigo em Espanhol | LILACS | ID: biblio-902586

RESUMO

Saprochaete capitata (S. capitata) fungal sepsis is a severe condition with a clinical presentation that is similar to other yeast originated fungal sepsis. It is observed in patients with hematological malignancies such as acute myeloid leukemia and neutropenia. We report a 23 year old male presenting with cough, fever and malaise. A bone marrow biopsy led to the diagnosis of acute myeloid leukemia. During the first cycle of chemotherapy the patient presented fever: blood cultures were positive for Klebsiella pneumoniae. Despite antimicrobial treatment, fever persisted; a computed tomography showed a focal splenic lesion; a left exudative pleural effusion appeared. A Matrix Assisted Laser Desorption Ionization-Time of Flight mass spectrometry identified the presence of S. capitata. After multiple antifungal treatments and pleural cavity cleansing by means of videothoracoscopy and laparoscopic splenectomy, the infection resolved and the patient completed his chemotherapy.


Assuntos
Humanos , Masculino , Adulto Jovem , Leucemia Mieloide Aguda/microbiologia , Fungemia/cirurgia , Dipodascus/isolamento & purificação , Pleurisia/microbiologia , Pleurisia/patologia , Esplenectomia/métodos , Esplenopatias/cirurgia , Esplenopatias/microbiologia , Esplenopatias/patologia , Drenagem/métodos , Resultado do Tratamento , Fungemia/patologia , Fungemia/tratamento farmacológico , Antifúngicos/uso terapêutico
3.
Rev Soc Bras Med Trop ; 44(5): 648-50, 2011 Oct.
Artigo em Português | MEDLINE | ID: mdl-22031088

RESUMO

The infections caused by Dipodascus capitatus are rare, and the treatment is difficult. We reported a case of a patient with acute myeloid leukemia. The fungus was first isolated from hemocultures, and the phenotypic identification was based on mycological methods. The genotyping was carried out by sequencing the region D1/D2 from 26 rDNA. The susceptibility tests were assayed by Etest® and by the microdilution technique. None of the antifungal treatments employed were effective. The patient died on day 17 after the mycological diagnosis. The authors discussed the emergence of such infections as well as the difficulty regarding the diagnosis and treatment.


Assuntos
Dipodascus/isolamento & purificação , Leucemia Mieloide Aguda/microbiologia , Micoses/microbiologia , Adolescente , DNA Fúngico/análise , DNA Ribossômico/análise , Dipodascus/genética , Evolução Fatal , Feminino , Genótipo , Humanos , Testes de Sensibilidade Microbiana
4.
Rev. Soc. Bras. Med. Trop ; Rev. Soc. Bras. Med. Trop;44(5): 648-650, Sept.-Oct. 2011. ilus, tab
Artigo em Português | LILACS | ID: lil-602915

RESUMO

As infecções causadas por Dipodascus capitatus são raras e de difícil tratamento. Aqui se relata um caso em paciente com leucemia mielocítica aguda. O isolamento fúngico ocorreu a partir de hemocultura e a identificação fenotípica baseou-se em métodos micológicos clássicos; a identificação genotípica foi realizada através do sequenciamento da região D1/D2 do 26 rDNA. Os testes de suscetibilidade foram realizados através do Etest® e microdiluição em caldo. A antifungicoterapia foi ineficaz, registrando-se óbito da paciente no 17° dia após o diagnóstico. Os autores comparam o caso com relatos similares e discutem a emergência destas infecções bem como suas dificuldades diagnósticas e terapêuticas.


The infections caused by Dipodascus capitatus are rare, and the treatment is difficult. We reported a case of a patient with acute myeloid leukemia. The fungus was first isolated from hemocultures, and the phenotypic identification was based on mycological methods. The genotyping was carried out by sequencing the region D1/D2 from 26 rDNA. The susceptibility tests were assayed by Etest® and by the microdilution technique. None of the antifungal treatments employed were effective. The patient died on day 17 after the mycological diagnosis. The authors discussed the emergence of such infections as well as the difficulty regarding the diagnosis and treatment.


Assuntos
Adolescente , Feminino , Humanos , Dipodascus/isolamento & purificação , Leucemia Mieloide Aguda/microbiologia , Micoses/microbiologia , DNA Fúngico/análise , DNA Ribossômico/análise , Dipodascus/genética , Evolução Fatal , Genótipo , Testes de Sensibilidade Microbiana
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