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1.
Artigo em Inglês | MEDLINE | ID: mdl-34501762

RESUMO

Narcissism is a multi-dimensional personality trait characterised by grandiosity, vanity, low empathy, and a desire for admiration. Previous research has suggested that social media sites are ideal platforms for people with narcissistic traits to satisfy a desire for attention. However, less is understood about the relationship between social media and vulnerable narcissism, characterised by vulnerability, insecurity, and oversensitivity. A total of 115 participants completed the Hypersensitive Narcissism Scale (HSNS) and questions relating to social media use. Exploratory and confirmatory factor analysis supported a two-factor model of vulnerable narcissism; oversensitivity and egocentrism. Results showed that greater oversensitivity was significantly associated with greater scores in all six aspects of social media use. Specifically, time spent on social media, frequency of posts, concerns about numbers of likes and comments, being overly sensitive about negative remarks, feelings of jealousy, and a greater difference in how they portray themselves on social media compared to real life. Egocentricity was significantly associated with less concern over negative remarks and a greater difference in how they portray themselves on social media compared to real life. These results suggest that vulnerable narcissism is not a unitary trait and that subfactors oversensitivity and egocentricity contribute differentially to aspects of social media use.


Assuntos
Egocentrismo , Mídias Sociais , Humanos , Ciúme , Narcisismo , Personalidade
2.
PLoS One ; 16(2): e0247703, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33635891

RESUMO

BACKGROUND: Self-focused attention and safety behaviours are both associated with adolescent social anxiety. In adults, experimental studies have indicated that the processes are causally implicated in social anxiety, but this hypothesis has not yet been tested in a youth sample. METHODS: This experiment explored this possibility by asking high and low socially anxious adolescents (N = 57) to undertake conversations under different conditions. During one conversation they were instructed to focus on themselves and use safety behaviours, and in the other they focused externally and did not use safety behaviours. Self-report, conversation partner report and independent assessor ratings were taken. RESULTS: Self-focus and safety behaviours increased feelings and appearance of anxiety and undermined performance for all participants, but only high socially anxious participants reported habitually using self-focus and safety behaviours. CONCLUSIONS: The findings provide support for the causal role of self-focus and safety behaviours in adolescent social anxiety and point to the potential clinical value of techniques reversing them to treat the disorder.


Assuntos
Transtornos de Ansiedade/psicologia , Ansiedade/psicologia , Atenção , Egocentrismo , Comportamentos Relacionados com a Saúde , Comportamento Social , Adolescente , Criança , Medo , Feminino , Humanos , Relações Interpessoais , Masculino , Autorrelato
3.
Psychol Res ; 85(3): 1005-1015, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32206856

RESUMO

Research in social cognition has shown that our own emotional experiences are an important source of information to understand what other people are feeling. The current study investigated whether individuals project their own affective states when reading other's emotional expressions. We used brief autobiographical recall and audiovisual stimuli to induce happy, neutral and sad transient states. After each emotion induction, participants made emotion judgments about ambiguous faces displaying a mixture of happiness and sadness. Using an adaptive psychophysics procedure, we estimated the tendency to perceive the faces as happy under each of the induced affective states. Results demonstrate the occurrence of egocentric projections, such that faces were more likely judged as happy when participants reported being happy as compared to when they were sad. Moreover, the degree of emotional egocentricity was associated with individual differences in perspective-taking, with smaller biases being observed in individuals with higher disposition to take the perspective of others. Our findings extend previous literature on emotional egocentricity by showing that self-projection occurs when we make emotion attributions based on the other's emotional expressions, and supports the notion that perspective-taking tendencies play a role in the ability to understand the other's affective states.


Assuntos
Egocentrismo , Emoções/fisiologia , Felicidade , Transtornos do Humor/fisiopatologia , Percepção Social/psicologia , Adulto , Feminino , Alemanha , Humanos , Masculino , Adulto Jovem
4.
Wiley Interdiscip Rev Cogn Sci ; 12(3): e1549, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33188569

RESUMO

Representations of space in mind are crucial for navigation, facilitating processes such as remembering landmark locations, understanding spatial relationships between objects, and integrating routes. A significant problem, however, is the lack of consensus on how these representations are encoded and stored in memory. Specifically, the nature of egocentric and allocentric frames of reference in human memory is widely debated. Yet, in recent investigations of the spatial domain across the lifespan, these distinctions in mnemonic spatial frames of reference have identified age-related impairments. In this review, we survey the ways in which different terms related to spatial representations in memory have been operationalized in past aging research and suggest a taxonomy to provide a common language for future investigations and theoretical discussion. This article is categorized under: Psychology > Memory Neuroscience > Cognition Psychology > Development and Aging.


Assuntos
Envelhecimento/fisiologia , Memória/fisiologia , Navegação Espacial , Egocentrismo , Humanos , Orientação/fisiologia
5.
PLoS One ; 15(10): e0240521, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33104751

RESUMO

Theory of Mind (ToM) is the ability to understand others' mental states, and that these mental states can differ from our own. Although healthy adults have little trouble passing conceptual tests of ToM (e.g., the false belief task [1]), they do not always succeed in using ToM [2,3]. In order to be successful in referential communication, listeners need to correctly infer the way in which a speaker's perspective constrains reference and inhibit their own perspective accordingly. However, listeners may require prompts to take these effortful inferential steps. The current study investigated the possibility of embedding prompts in the instructions for listeners to make inference about using a speaker's perspective. Experiment 1 showed that provision of a clear introductory example of the full chain of inferences resulted in large improvement in performance. Residual egocentric errors suggested that the improvement was not simply due to superior comprehension of the instructions. Experiment 2 further dissociated the effect by placing selective emphasis on making inference about inhibiting listeners' own perspective versus using the speaker's perspective. Results showed that only the latter had a significant effect on successful performance. The current findings clearly demonstrated that listeners do not readily make inferences about using speakers' perspectives, but can do so when prompted.


Assuntos
Egocentrismo , Teoria da Mente , Comunicação , Compreensão , Feminino , Humanos , Masculino , Adulto Jovem
6.
Artigo em Inglês | MEDLINE | ID: mdl-33096643

RESUMO

BACKGROUND: Although studies have examined the influence of materialism on adolescent well-being, there are several methodological limitations: studies examining the influence of materialism on adolescent delinquency are almost non-existent; researchers commonly used cross-sectional designs; the sample size in some studies was not large; validated measures on materialism in non-Western contexts are rare; there are very few Chinese studies. Besides, no study has examined the hypothesis that egocentrism is the mediator in the influence of materialism on adolescent delinquency. METHODS: Using a short-term longitudinal design, two waves of data were collected from 2648 early adolescents in mainland China. At each wave, students completed validated measures of materialism, egocentrism and delinquent behavior. RESULTS: Materialism and egocentrism positively predicted adolescent delinquency at Wave 1 and Wave 2 and over time. While materialism at Wave 1 positively predicted increase in delinquency over time, egocentrism did not. However, PROCESS analysis showed that egocentrism mediated the longitudinal influence of materialism on adolescent delinquent behavior. CONCLUSIONS: Materialism and egocentrism are predictors of adolescent delinquency, with egocentrism serving as a mediator in the influence of materialism on adolescent delinquency.


Assuntos
Comportamento do Adolescente , Delinquência Juvenil , Adolescente , Grupo com Ancestrais do Continente Asiático , China/epidemiologia , Estudos Transversais , Egocentrismo , Feminino , Humanos , Estudos Longitudinais , Masculino
7.
Psychon Bull Rev ; 27(6): 1341-1347, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32779118

RESUMO

Many perspective-taking and theory of mind tasks require participants to pass over the answer that is optimal from the self-perspective. For instance, in the classic change-of-location (false belief) task, participants are required to ignore where they know the object to be, and in the director task participants are required to ignore the best match for the instruction the other, less knowledgeable agent gives them (e.g., 'the top cup'). However, a second but equally critical requirement in such tasks is the ability to select a response which is wrong from the self-perspective; where the object is not, or an object that does not match the instruction (e.g., the middle cup instead of the top cup from one's own perspective). We present the results of an experiment that teases apart these two effects and demonstrate that both contribute independently to the difficulty in taking other perspectives. Reanalyses of data from previous experiments confirm this dual effect. These results suggest a revision of our understanding of egocentricity and difficulty in perspective-taking generally.


Assuntos
Egocentrismo , Orientação , Reconhecimento Visual de Modelos , Resolução de Problemas , Teoria da Mente , Adolescente , Adulto , Comunicação , Aprendizagem por Discriminação , Feminino , Humanos , Masculino , Tempo de Reação , Teoria da Mente/fisiologia , Adulto Jovem
8.
PLoS One ; 15(5): e0233378, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32470005

RESUMO

We investigated the effects of long-term exposure to literary and popular fiction on attributional complexity, egocentric bias and accuracy. Results of a pre-registered study showed that exposure to literary fiction is positively associated with scores on the attributional complexity scale. Literary fiction is also associated with accuracy in mentalizing, measured via the Reading the Mind in the Eyes test, and with accuracy in predicting average social attitudes. The predicted negative association between literary fiction and egocentric bias emerged only when education and gender were controlled for-a covariance analysis that was not pre-registered. Exposure to popular fiction is associated solely with attributional complexity, but negatively. We discuss the significance of these findings in the context of the emerging literature regarding the relationship between fiction and social cognition.


Assuntos
Obras de Ficção como Assunto , Percepção Social , Adulto , Atitude , Egocentrismo , Feminino , Humanos , Masculino , Mentalização , Pessoa de Meia-Idade , Modelos Psicológicos , Comportamento Social , Teoria da Mente , Adulto Jovem
9.
Q J Exp Psychol (Hove) ; 73(9): 1466-1480, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32292104

RESUMO

Although self-relevance is widely acknowledged to enhance stimulus processing, the exclusivity of this effect remains open to question. In particular, in commonly adopted experimental paradigms, the prioritisation of self-relevant (vs. other-relevant) material may reflect the operation of a task-specific strategy rather than an obligatory facet of social-cognitive functioning. By changing basic aspects of the decisional context, it may therefore be possible to generate stimulus-prioritisation effects for targets other than the self. Based on the demonstration that ownership facilitates object categorisation (i.e., self-ownership effect), here we showed that stimulus prioritisation is sensitive to prior expectations about the prevalence of forthcoming objects (owned-by-self vs. owned-by-friend) and whether these beliefs are supported during the task. Under conditions of stimulus uncertainty (i.e., no prior beliefs), replicating previous research, objects were classified more rapidly when owned-by-self compared with owned-by-friend (Experiment 1). When, however, the frequency of stimulus presentation either confirmed (Experiment 2) or disconfirmed (Experiment 3) prior expectations, stimulus prioritisation was observed for the most prevalent objects regardless of their owner. A hierarchical drift diffusion model (HDDM) analysis further revealed that decisional bias was underpinned by differences in the evidential requirements of response generation. These findings underscore the flexibility of ownership effects (i.e., stimulus prioritisation) during object processing.


Assuntos
Egocentrismo , Propriedade , Tomada de Decisões , Feminino , Humanos , Masculino , Tempo de Reação , Incerteza , Adulto Jovem
10.
Sci Adv ; 6(8): eaaz2322, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-32128423

RESUMO

The retrosplenial cortex is reciprocally connected with multiple structures implicated in spatial cognition, and damage to the region itself produces numerous spatial impairments. Here, we sought to characterize spatial correlates of neurons within the region during free exploration in two-dimensional environments. We report that a large percentage of retrosplenial cortex neurons have spatial receptive fields that are active when environmental boundaries are positioned at a specific orientation and distance relative to the animal itself. We demonstrate that this vector-based location signal is encoded in egocentric coordinates, is localized to the dysgranular retrosplenial subregion, is independent of self-motion, and is context invariant. Further, we identify a subpopulation of neurons with this response property that are synchronized with the hippocampal theta oscillation. Accordingly, the current work identifies a robust egocentric spatial code in retrosplenial cortex that can facilitate spatial coordinate system transformations and support the anchoring, generation, and utilization of allocentric representations.


Assuntos
Egocentrismo , Animais , Córtex Cerebral/fisiologia , Córtex Entorrinal/fisiologia , Comportamento Exploratório , Modelos Lineares , Masculino , Movimento (Física) , Córtex Motor/fisiologia , Neurônios/fisiologia , Ratos Long-Evans , Ritmo Teta/fisiologia
11.
Q J Exp Psychol (Hove) ; 73(9): 1368-1381, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32186240

RESUMO

Previous research has suggested that adults are sometimes egocentric, erroneously attributing their current beliefs, perspectives, and opinions to others. Interestingly, this egocentricity is sometimes stronger when perspective-taking than when working from functionally identical but non-perspectival rules. Much of our knowledge of egocentric bias comes from Level 1 perspective-taking (e.g., judging whether something is seen) and judgements made about narrated characters or avatars rather than truly social stimuli such as another person in the same room. We tested whether adults would be egocentric on a Level 2 perspective-taking task (judging how something appears), in which they were instructed to indicate on a continuous colour scale the colour of an object as seen through a filter. In our first experiment, we manipulated the participants' knowledge of the object's true colour. We also asked participants to judge either what the filtered colour looked like to themselves or to another person present in the room. We found participants' judgements did not vary across conditions. In a second experiment, we instead manipulated how much participants knew about the object's colour when it was filtered. We found that participants were biased towards the true colour of the object when making judgements about targets they could not see relative to targets they could, but that this bias disappeared when the instruction was to imagine what the object looked like to another person. We interpret these findings as indicative of reduced egocentricity when considering other people's experiences of events relative to considering functionally identical but abstract rules.


Assuntos
Egocentrismo , Julgamento , Teoria da Mente , Adolescente , Adulto , Viés , Feminino , Humanos , Masculino , Adulto Jovem
12.
J Pers ; 88(2): 339-355, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-31173651

RESUMO

OBJECTIVE: This research presents evidence for an egocentric shift occurring among individuals high in Neuroticism by the mere thought-and actual state-of being alone. METHOD: Four experiments and one experience sampling study (N = 719). In the experiments, Neuroticism was measured, and participants were randomly primed to adopt either an alone or a "with others" social context mind-set. The experiments measured different expressions of egocentrism. Study 1 measured perspective-taking, Study 2a was focused on social value orientation, Study 2b measured money allocation in a dictator game, and Study 3 measured self-reported and behavioral interpersonal trust. Trust was also the focus of Study 4, a 5-day experience sampling study. RESULTS: In an alone mind-set, high (vs. low) Neuroticism individuals were more likely to adopt an egocentric perspective in evaluating social stimuli (Study 1) and to adopt a selfish approach to money allocation (Studies 2a, 2b). Studies 3 and 4 addressed the source of the shift, showing that in an alone mind-set (Study 3) and in an actual alone state (Study 4), Neuroticism was associated with reduced interpersonal trust. CONCLUSIONS: For high-Neuroticism individuals, thinking about-and actually being-alone induces a sense that they only have themselves to rely on.


Assuntos
Egocentrismo , Solidão , Neuroticismo , Percepção Social , Valores Sociais , Confiança , Adulto , Avaliação Momentânea Ecológica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
13.
J Gerontol B Psychol Sci Soc Sci ; 75(9): e242-e248, 2020 10 16.
Artigo em Inglês | MEDLINE | ID: mdl-30852612

RESUMO

OBJECTIVES: Older adults are often judged to be warm, but not competent, which contradicts their representation in positions of authority. This study sought to extend evidence of age differences in more individualistic (e.g., "I") and collectivistic (e.g., "we") language and explore their impact on judgments of performance and electability. METHOD: Speeches from young and older adults who campaigned for a fictitious position were analyzed using Linguistic and Inquiry Word Count Software. Words fitting specified categories (e.g., pronouns, affect) were compared to outcome judgments obtained from trained coders on the dimensions of performance and electability. RESULTS: Older adults used significantly more "we"-language. Young adults used more "I"-language, and more positive affect, achievement, and power language. Language choices and coder judgments were associated such that the more "I"-language that was used during the speech, the less electable the candidate was judged. This relationship was not found for "we"-language. DISCUSSION: This study found no evidence for collectivistic language enhancing ratings of electability or performance; however, an age-invariable, negative relationship was obtained between increased individualistic language and reduced coder judgments of electability. This suggests that speakers should minimize "I"-statements to promote electability, a characteristic that is reflected more in older adults' speeches than young.


Assuntos
Envelhecimento/psicologia , Comportamento Cooperativo , Egocentrismo , Julgamento , Idioma , Fala , Adulto , Fatores Etários , Idoso , Feminino , Humanos , Linguística/métodos , Masculino , Comportamento Social , Habilidades Sociais , Comportamento Estereotipado , Comportamento Verbal
14.
Hippocampus ; 30(4): 332-353, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-31697002

RESUMO

A theory and model of spatial coordinate transforms in the dorsal visual system through the parietal cortex that enable an interface via posterior cingulate and related retrosplenial cortex to allocentric spatial representations in the primate hippocampus is described. First, a new approach to coordinate transform learning in the brain is proposed, in which the traditional gain modulation is complemented by temporal trace rule competitive network learning. It is shown in a computational model that the new approach works much more precisely than gain modulation alone, by enabling neurons to represent the different combinations of signal and gain modulator more accurately. This understanding may have application to many brain areas where coordinate transforms are learned. Second, a set of coordinate transforms is proposed for the dorsal visual system/parietal areas that enables a representation to be formed in allocentric spatial view coordinates. The input stimulus is merely a stimulus at a given position in retinal space, and the gain modulation signals needed are eye position, head direction, and place, all of which are present in the primate brain. Neurons that encode the bearing to a landmark are involved in the coordinate transforms. Part of the importance here is that the coordinates of the allocentric view produced in this model are the same as those of spatial view cells that respond to allocentric view recorded in the primate hippocampus and parahippocampal cortex. The result is that information from the dorsal visual system can be used to update the spatial input to the hippocampus in the appropriate allocentric coordinate frame, including providing for idiothetic update to allow for self-motion. It is further shown how hippocampal spatial view cells could be useful for the transform from hippocampal allocentric coordinates to egocentric coordinates useful for actions in space and for navigation.


Assuntos
Hipocampo/fisiologia , Memória/fisiologia , Redes Neurais de Computação , Lobo Parietal/fisiologia , Percepção Espacial/fisiologia , Navegação Espacial/fisiologia , Animais , Egocentrismo , Hipocampo/citologia , Humanos , Lobo Parietal/citologia , Primatas
15.
Cogn Emot ; 34(4): 756-770, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-31672095

RESUMO

We often use our own emotions to understand other people's emotions. However, emotional egocentric biases (EEB), namely the tendency to use one's own emotional state when relating to others' emotions, may hinder this process, especially when emotions are incongruent. We capitalised on the classic EEB task to develop a new version that is easier to implement and control. Unlike the original EEB task that relies on a combination of private (e.g. touch) and public (e.g. vision) sensory information, our EEB task (AV-EEB) used audio-visual stimuli to evoke congruent/incongruent emotions in participants. Auditory and visual signals are both public, in that they can be shared among individuals, and make the task easier to implement and control. We provide lab-based and online validations of the AV-EEB, and demonstrate a positive relationship between EEB and social negative potency. This new, easily implemented version of the EEB task can accelerate the investigation of egocentricity biases in several research areas.


Assuntos
Viés , Egocentrismo , Emoções , Estimulação Acústica/métodos , Adulto , Feminino , Humanos , Masculino , Estimulação Luminosa/métodos , Testes Psicológicos , Adulto Jovem
16.
J Health Commun ; 25(12): 931-942, 2020 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-33656415

RESUMO

This study conceptually and empirically distinguishes two mental processes in narrative processing of food safety health messages-identification with and egocentric projection onto story characters. Two studies examined the effects of narrative autobiographical accounts of contracting foodborne illness (salmonella) because of careless food preparation. Both studies consistently found that identification increased, but egocentric projection decreased audience members' behavioral intention to perform safe food handling practices, indicating that egocentric projection and identification represent unique mental processes and yield distinct persuasive outcomes. In addition, confirmatory factor analyses provided evidence that egocentric projection and identification are distinct constructs. Implications for the role of identification and egocentric projection for understanding narrative processing and for health persuasion are discussed.


Assuntos
Doenças Transmitidas por Alimentos , Comunicação em Saúde/métodos , Narração , Comunicação Persuasiva , Adulto , Egocentrismo , Feminino , Humanos , Identificação Psicológica , Masculino
18.
Sci Rep ; 9(1): 10985, 2019 07 29.
Artigo em Inglês | MEDLINE | ID: mdl-31358812

RESUMO

Depending on the point of view, conceptions of greed range from being a desirable and inevitable feature of a well-regulated, well-balanced economy to the root of all evil - radix omnium malorum avaritia (Tim 6.10). Regarding the latter, it has been proposed that greedy individuals strive for obtaining desired goods at all costs. Here, we show that trait greed predicts selfish economic decisions that come at the expense of others in a resource dilemma. This effect was amplified when individuals strived for obtaining real money, as compared to points, and when their revenue was at the expense of another person, as compared to a computer. On the neural level, we show that individuals high, compared to low in trait greed showed a characteristic signature in the EEG, a reduced P3 effect to positive, compared to negative feedback, indicating that they may have a lack of sensitivity to adjust behavior according to positive and negative stimuli from the environment. Brain-behavior relations further confirmed this lack of sensitivity to behavior adjustment as a potential underlying neuro-cognitive mechanism which explains selfish and reckless behavior that may come at the expense of others.


Assuntos
Encéfalo/fisiologia , Comportamento Social , Adulto , Egocentrismo , Eletroencefalografia , Feminino , Administração Financeira , Humanos , Masculino , Adulto Jovem
19.
Autism Res ; 12(11): 1598-1608, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31102339

RESUMO

Individuals with autism spectrum conditions (ASCs) often experience difficulty and confusion in acknowledging others' perspectives and arguably exhibit egocentricity. However, whether this egocentricity necessarily results in selfish behavior during social situations remains a matter of debate. To study this relationship, we used computerized visuospatial perspective-taking task (VPT) and social-discounting task (SDT), derived from cognitive psychology and behavioral economics, and examined egocentric and other-oriented judgments in participants with ASCs (mean age 29.0 ± 4.2 years) and a group of matched typically developing (TD) controls (30.8 ± 8.5). The response time in VPT showed altered perspective-taking in the ASCs group compared with the TD group that involved in enhanced self-other intrusion and condition-insensitive response. Regardless of self/other perspective judgments, responses were relatively slower and consistent in duration in the ASCs group compared with the TD group. Social discounting was attenuated rather than steep discounting in the ASCs group. Their discounting was comparatively more consistent, irrespective of the task condition (i.e., self-other closeness-level). In effect, ASCs group exhibited more generous decisions than the TD group in this task. Finally, those with more egocentric perspective intrusion in VPT paradoxically showed more generous behaviors in SDT in the ASCs group. Our findings suggest that having ASCs does not always exhibit selfish behavior during interpersonal communication. Reduced flexibility in distinguishing self/other perspective and shifting decision-rules might account for this unique relationship between egocentricity and apparently generous behaviors. These results extend the recent suggestion that more careful attention should be paid to the idea of egocentricity in individuals with ASCs. Autism Res 2019. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We aimed to examine whether seeing the world from another person's point of view and being generous toward other people are related in autistic and nonautistic people. We used a visual perspective-taking task and a social task in which individuals made decisions about how to divide a sum of money with others. Our results suggest that being autistic does not always make someone bad at seeing the world from another's viewpoint, and that autistic people may make fairer social decisions toward unfamiliar people because of lower bias.


Assuntos
Transtorno do Espectro Autista/fisiopatologia , Transtorno do Espectro Autista/psicologia , Egocentrismo , Julgamento/fisiologia , Comportamento Social , Adulto , Feminino , Humanos , Masculino , Tempo de Reação/fisiologia
20.
Psychopharmacology (Berl) ; 236(7): 2243-2258, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30919007

RESUMO

RATIONALE: Methamphetamine (MA) is an abused psychostimulant that causes cognitive deficits after chronic use. Neostriatal dopamine receptors play a role in MA monoamine neurotoxicity. Blocking dopamine receptors prior to MA exposure in adult rats attenuates monoamine reductions and reactive gliosis. OBJECTIVES: We tested whether blocking dopamine receptors protects against cognitive deficits. METHODS: First, we determined the effects of MA alone versus MA in combination with the dopamine receptor D1 antagonist SCH-23390 or the dopamine receptor D2 antagonist sulpiride on cFos expression and monoamines at the age when rats in the cognitive experiment were to begin testing and monoamines in rats after cognitive testing. RESULTS: SCH-23390 infused into the neostriatum prior to systemic administration of MA attenuated MA-induced cFos activation while sulpiride induced cFos activation. Two weeks after MA, rats had dopamine and serotonin reductions that were attenuated by each antagonist. Other rats treated the same way, were tested for egocentric learning and memory in the Cincinnati water maze, for navigational strategy in a star water maze, and spatial learning and memory in a Morris water maze. Pre-treatment with SCH-23390 or sulpiride attenuated the effects of MA on egocentric and spatial learning and memory. MA-treated rats showed a shift from an egocentric to a disorganized strategy in the star maze that was less disorganized in groups receiving MA and an antagonist. Post-behavior monoamine reductions remained but were attenuated by the antagonists but not identically to what was seen in rats not behaviorally tested. CONCLUSIONS: The results show for the first time that dopamine receptors are mediators of MA-induced cognitive deficits.


Assuntos
Antagonistas dos Receptores de Dopamina D2/uso terapêutico , Aprendizagem em Labirinto/efeitos dos fármacos , Transtornos da Memória/induzido quimicamente , Transtornos da Memória/tratamento farmacológico , Metanfetamina/toxicidade , Receptores de Dopamina D1/antagonistas & inibidores , Animais , Estimulantes do Sistema Nervoso Central/farmacologia , Estimulantes do Sistema Nervoso Central/toxicidade , Dopamina/metabolismo , Antagonistas de Dopamina/farmacologia , Antagonistas de Dopamina/uso terapêutico , Antagonistas dos Receptores de Dopamina D2/farmacologia , Egocentrismo , Injeções Intraventriculares , Masculino , Aprendizagem em Labirinto/fisiologia , Transtornos da Memória/metabolismo , Metanfetamina/farmacologia , Neostriado/efeitos dos fármacos , Neostriado/metabolismo , Ratos , Ratos Sprague-Dawley , Receptores de Dopamina D1/metabolismo , Receptores de Dopamina D2/metabolismo
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