RESUMO
Triboelectric nanogenerators (TENGs) have garnered considerable interest as a promising technology for energy harvesting and stimulus sensing. While TENGs facilitate the generation of electricity from micro-motions, the modular design of TENG-based modular sensing systems (TMSs) also offers significant potential for powering biosensors and other medical devices, thus reducing dependence on external power sources and enabling biological processes to be monitored in real time. Moreover, TENGs can be customised and personalized to address individual patient needs while ensuring biocompatibility and safety, ultimately enhancing the efficiency and security of diagnosis and treatment. In this review, we concentrate on recent advancements in the modular design of TMSs for clinical applications with an emphasis on their potential for personalised real-time diagnosis. We also examine the design and fabrication of TMSs, their sensitivity and specificity, and their capabilities of detecting biomarkers for disease diagnosis and monitoring. Furthermore, we investigate the application of TENGs to energy harvesting and real-time monitoring in wearable and implantable medical devices, underscore the promising prospects of personalised and modular TMSs in advancing real-time diagnosis for clinical applications, and offer insights into the future direction of this burgeoning field.
Assuntos
Fontes de Energia Elétrica , Eletricidade , Humanos , Movimento (Física) , Resolução de Problemas , TecnologiaRESUMO
The protein scaffolds of enzymes not only provide structural support for the catalytic center but also exert preorganized electric fields for electrostatic catalysis. In recent years, uniform oriented external electric fields (OEEFs) have been widely applied to enzymatic reactions to mimic the electrostatic effects of the environment. However, the electric fields exerted by individual residues in proteins may be quite heterogeneous across the active site, with varying directions and strengths at different positions of the active site. Here, we propose a QM/MM-based approach to evaluate the effects of the electric fields exerted by individual residues in the protein scaffold. In particular, the heterogeneity of the residue electric fields and the effect of the native protein environment can be properly accounted for by this QM/MM approach. A case study of the O-O heterolysis reaction in the catalytic cycle of TyrH shows that (1) for scaffold residues that are relatively far from the active site, the heterogeneity of the residue electric field in the active site is not very significant and the electrostatic stabilization/destabilization due to each residue can be well approximated with the interaction energy between a uniform electric field and the QM region dipole; (2) for scaffold residues near the active site, the residue electric fields can be highly heterogeneous along the breaking O-O bond. In such a case, approximating the residue electric fields as uniform fields may misrepresent the overall electrostatic effect of the residue. The present QM/MM approach can be applied to evaluate the residues' electrostatic impact on enzymatic reactions, which also can be useful in computational optimization of electric fields to boost the enzyme catalysis.
Assuntos
Eletricidade , Proteínas , Proteínas/química , Eletricidade Estática , CatáliseRESUMO
Mild concussions occur frequently and may come with long-term cognitive, affective, and physical sequelae. However, the diagnosis of mild concussions lacks objective assessment and portable monitoring techniques. Here, we propose a multiangle self-powered sensor array for real-time monitoring of head impact to further assist in clinical analysis and prevention of mild concussions. The array uses triboelectric nanogenerator technology, which converts impact force from multiple directions into electrical signals. With an average sensitivity of 0.214 volts per kilopascal, a response time of 30 milliseconds, and a minimum resolution of 1.415 kilopascals, the sensors exhibit excellent sensing capability over a range of 0 to 200 kilopascals. Furthermore, the array enables reconstructed head impact mapping and injury grade assessment via a prewarning system. By gathering standardized data, we expect to build a big data platform that will permit in-depth research of the direct and indirect effects between head impacts and mild concussions in the future.
Assuntos
Concussão Encefálica , Humanos , Concussão Encefálica/diagnóstico , Fontes de Energia Elétrica , Previsões , EletricidadeRESUMO
The battery driving mileage on a single charge and convenience of the charging stations affect Electric Vehicle's (EV) demand. This paper studies the optimal number of charging stations and EV's price strategy considering different component commonality configurations. Assume the EV manufacturer provides two types of EV and the two EVs have the same battery configuration (battery as a common part) or the same naked vehicle-EV without batteries (naked vehicle as a common part). And the common part could be configured with low or high quality. We discuss four scenarios with different common parts and different quality levels. For each scenario, we present the optimal number of the charging stations and EV prices. Then we compare the optimal solutions and manufacturer's profits in above four scenarios with numerical simulation and give some managerial insights. Our analysis reveals that (1) consumers' range anxiety towards battery will affect manufacturer's product configuration strategy, EVs' prices and demands. (2) large consumers' sensitivity towards charging station will corresponding to more charging station, high EV prices and demands. If consumers are very concerned about the charging convenience, high-end electric vehicles need to be launched first, then as customers' anxiety about charging decreases, the low quality EV could be developed and diffused. (3) the unit product cost reduction caused by the commonality may increase or decrease the EVs' prices, which depends on the relationship between the demand increment incurred by one more charging station and the cost coefficient of building the charging station. (4) The low quality naked vehicle as common component will increase both the number of the charging stations and the demand and the manufacturer is more likely to obtain high profits. (5) the cost saving coefficient of battery common parts has greater influence on the selection of commonality. When consumers' range anxiety towards battery is very high, manufacturers should choose low-quality naked vehicles or high-quality battery as common components.
Assuntos
Fontes de Energia Elétrica , Eletricidade , Simulação por Computador , Custos e Análise de Custo , AnsiedadeRESUMO
Triboelectric nanogenerators (TENGs) can not only collect mechanical energy around or inside the human body and convert it into electricity but also help monitor our body and the world by providing interpretable electrical signals during energy conversion, thus emerging as an innovative medical solution for both daily health monitoring and clinical treatment and bringing great convenience. This review tries to introduce the latest technological progress of TENGs for applications in biophysical sensors, where a TENG functions as a either a sensor or a power source, and in some cases, as both parts of a self-powered sensor system. From this perspective, this review begins from the fundamental working principles and then concisely illustrates the recent progress of TENGs given structural design, surface modification, and materials selection toward output enhancement and medical application flexibility. After this, the medical applications of TENGs in respiratory status, cardiovascular disease, and human rehabilitation are covered in detail, in the form of either textile or implantable parts for pacemakers, nerve stimulators, and nerve prostheses. In addition, the application of TENGs in driving third-party medical treatment systems is introduced. Finally, shortcomings and challenges in TENG-based biophysical sensors are highlighted, aiming to provide deeper insight into TENG-based medical solutions for the development of TENG-based self-powered electronics with higher performance for practical applications.
Assuntos
Doenças Cardiovasculares , Medicina , Humanos , Fontes de Energia Elétrica , Eletricidade , EletrônicaRESUMO
Two reciprocating membranes (rMBR) with two frequencies of 0.46 Hz (rMBR-0.46) and 0.3 Hz (rMBR-0.3) were operated to compare the treatment performance and gross energy consumption with a conventional MBR. The average organic removal rates of MBR, rMBR-0.46 and rMBR-0.3 were maintained 295 ± 51; 823 ± 296; and 397 ± 129 mgCOD/gVSS.d, respectively. Nitrogen removal was enhanced in rMBR phases compared to conventional MBR phase due to anoxic membrane chamber. Further, fouling rate was found to be highest of 16.5 mbar/day (at conventional MBR phase), which was and much decreased to1.0 mbar/day (at rMBR-0.46 phase) and then 0.2 mbar/day (rMBR-0.3 phase). The reciprocation membrane also showed energy potential by saving 10.6% electricity for each treated cubic meter of wastewater compared to the conventional MBR.
Assuntos
Membranas Artificiais , Águas Residuárias , Eletricidade , Reatores Biológicos , Nitrogênio , EsgotosRESUMO
A three-dimensional electrocatalytic biofilter (3DEBF) was constructed to remove clofibric acid (CA). This study compared the effectiveness of 3DEBF and biological aerated filter (BAF) in the removal of refractory CA, examined the effects of influent CA concentrations (0.1, 0.3, 0.5, 0.7, and 1.0 mg/L) on microbial community, and proposed a possible 3DEBF degradation mechanism. Results indicated that the average removal efficiency of 3DEBF reached a peak (76.09%) at 0.7 mg/L, which was 14.43% higher than that of BAF. Based on the microbial community analysis, the significant enrichment of Rhodobacter, Mycobacterium, and Sphingopyxis in 3DEBF was associated with the effect of the CA concentration and the electric field. The degradation pathway indicated that xenobiotics biodegradation and metabolism, membrane transport and replication and repair related genes were upregulated in 3DEBAF. Moreover, CA degradation is based on a combination of adsorption, electrochemical oxidation, and biodegradation.
Assuntos
Filtração , Microbiota , Filtração/métodos , Biodegradação Ambiental , Eletricidade , Redes e Vias MetabólicasRESUMO
The diverse excitabilities of cells often produce various spiking-bursting oscillations that are found in the neural system. We establish the ability of a fractional-order excitable neuron model with Caputo's fractional derivative to analyze the effects of its dynamics on the spike train features observed in our results. The significance of this generalization relies on a theoretical framework of the model in which memory and hereditary properties are considered. Employing the fractional exponent, we first provide information about the variations in electrical activities. We deal with the 2D class I and class II excitable Morris-Lecar (M-L) neuron models that show the alternation of spiking and bursting features including MMOs & MMBOs of an uncoupled fractional-order neuron. We then extend the study with the 3D slow-fast M-L model in the fractional domain. The considered approach establishes a way to describe various characteristics similarities between fractional-order and classical integer-order dynamics. Using the stability and bifurcation analysis, we discuss different parameter spaces where the quiescent state emerges in uncoupled neurons. We show the characteristics consistent with the analytical results. Next, the Erdös-Rényi network of desynchronized mixed neurons (oscillatory and excitable) is constructed that is coupled through membrane voltage. It can generate complex firing activities where quiescent neurons start to fire. Furthermore, we have shown that increasing coupling can create cluster synchronization, and eventually it can enable the network to fire in unison. Based on cluster synchronization, we develop a reduced-order model which can capture the activities of the entire network. Our results reveal that the effect of fractional-order depends on the synaptic connectivity and the memory trace of the system. Additionally, the dynamics captures spike frequency adaptation and spike latency that occur over multiple timescales as the effects of fractional derivative, which has been observed in neural computation.
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Eletricidade , Neurônios , Potenciais de Ação/fisiologia , Neurônios/fisiologia , Modelos NeurológicosRESUMO
Addressing the impacts of climate change has become a global public crisis and challenge. China is characterized by a complex and diverse topography and vast territory, which makes it worthwhile to explore the differential impacts of climate change on urban electricity consumption in different zones and economic development conditions. This study examines the differential impact of climate factors on urban electricity consumption in China based on monthly panel data for 282 prefectures from 2011 to 2019 and projects the potential demand for future urban electricity consumption under different climate change scenarios. The results show that (1) temperature changes significantly alter urban electricity consumption, with cooling degree days (CDD) and heating degree days (HDD) contributing positively to urban electricity consumption in areas with different regional and economic development statuses, with elasticity coefficients of 0.1015-0.1525 and 0.0029-0.0077, respectively. (2) The temperature-electricity relationship curve shows an irregular U-shape. Each additional day of extreme weather above 30 °C and below -12 °C increases urban electricity consumption by 0.52% and 1.52% in the north and by 2.67% and 1.32% in the south. Poor cities are significantly more sensitive to extremely low temperatures than rich cities. (3) Suppose the impacts of climate degradation on urban electricity consumption are not halted. In that case, the possible Shared Socioeconomic Pathways 1-1.9 (SSP1-1.9), SSP1-2.6, and SSP2-4.5 will increase China's urban electricity consumption by 1621.96 billion kWh, 2960.87 billion kWh, and 6145.65 billion kWh, respectively, by 2090. Finally, this study makes some policy recommendations and expectations for follow-up studies.
Assuntos
Mudança Climática , Desenvolvimento Econômico , Cidades , China , EletricidadeRESUMO
As an industry with immense decarbonization potential, the low-carbon transformation of the power sector is crucial to China's carbon emission (CE) reduction commitment. Based on panel data of 30 provinces in China from 2000 to 2019, this research calculates and analyzes the provincial CE intensity in electricity generation (CEIE) and its spatial distribution characteristics. Additionally, the GTWR model based on the construction explains the regional heterogeneity and dynamic development trend of each driving factor's influence on CEIE from time and space. The main results are as follows: CEIE showed a gradual downward trend in time and a spatial distribution pattern of high in the northeast and low in the southwest. The contribution of driving factors to CEIE has regional differences, and the power structure contributes most to the CEIE of the power sector, which promotes regional CE. Concurrently, most provinces with similar economic development, technological level, geographic location, or resource endowment characteristics show similar spatial and temporal trends. These detections will furnish broader insights into implementing CE reduction policies for the regional power sector.
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Dióxido de Carbono , Carbono , Carbono/análise , Dióxido de Carbono/análise , Eletricidade , China , Desenvolvimento EconômicoRESUMO
Solid-state nanopores (ssNPs) are single-molecule sensors capable of label-free quantification of different biomolecules, which have become highly versatile with the introduction of different surface treatments. By modulating the surface charges of the ssNP, the electro-osmotic flow (EOF) can be controlled in turn affecting the in-pore hydrodynamic forces. Herein, we demonstrate that negative charge surfactant coating to ssNPs generates EOF that slows-down DNA translocation speed by >30-fold, without deterioration of the NP noise, hence significantly improving its performances. Consequently, surfactant-coated ssNPs can be used to reliably sense short DNA fragments at high voltage bias. To shed light on the EOF phenomena inside planar ssNPs, we introduce visualization of the electrically neutral fluorescent molecule's flow, hence decoupling the electrophoretic from EOF forces. Finite elements simulations are then used to show that EOF is likely responsible for in-pore drag and size-selective capture rate. This study broadens ssNPs use for multianalyte sensing in a single device.
Assuntos
DNA , Nanoporos , Eletricidade , Tensoativos , NanotecnologiaRESUMO
Transparent hydrogels have found increasing applications in wearable electronics, printable devices, and tissue engineering. Integrating desired properties, such as conductivity, mechanical strength, biocompatibility, and sensitivity, in one hydrogel remains challenging. To address these challenges, multifunctional hydrogels of methacrylate chitosan, spherical nanocellulose, and ß-glucan with distinct physicochemical characteristics were combined to develop multifunctional composite hydrogels. The nanocellulose facilitated the self-assembly of the hydrogel. The hydrogels exhibited good printability and adhesiveness. Compared with the pure methacrylated chitosan hydrogel, the composite hydrogels exhibited improved viscoelasticity, shape memory, and conductivity. The biocompatibility of the composite hydrogels was monitored using human bone marrow-derived stem cells. Their motion-sensing potential was analyzed on different parts of the human body. The composite hydrogels also possessed temperature-responsiveness and moisture-sensing abilities. These results suggest that the developed composite hydrogels demonstrate excellent potential to fabricate 3D-printable devices for sensing and moist electric generator applications.
Assuntos
Adesivos , Quitosana , Humanos , Condutividade Elétrica , Eletricidade , HidrogéisRESUMO
Harvesting biomechanical energy for electricity as well as physiological monitoring is a major development trend for wearable devices. In this article, we report a wearable triboelectric nanogenerator (TENG) with a ground-coupled electrode. It has a considerable output performance for harvesting human biomechanical energy and can also be used as a human motion sensor. The reference electrode of this device achieves a lower potential by coupling with the ground to form a coupling capacitor. Such a design can significantly improve the TENG's outputs. A maximum output voltage up to 946 V and a short-circuit current of 36.3 µA are achieved. The quantity of the charge that transfers during one step of an adult walking reaches 419.6 nC, while it is only 100.8 nC for the separate single-electrode-structured device. In addition, using the human body as a natural conductor to connect the reference electrode allows the device to drive the shoelaces with integrated LEDs. Finally, the wearable TENG is able to perform motion monitoring and sensing, such as human gait recognition, step count and movement speed calculation. These show great application prospects of the presented TENG device in wearable electronics.
Assuntos
Eletricidade , Dispositivos Eletrônicos Vestíveis , Adulto , Humanos , Movimento (Física) , Eletrodos , EletrônicaRESUMO
In contemporary science and technology, photonic sensors are essential. They may be made to be extremely resistant to some physical parameters while also being extremely sensitive to other physical variables. Most photonic sensors may be incorporated on chips and operate with CMOS technology, making them suitable for use as extremely sensitive, compact, and affordable sensors. Photonic sensors can detect electromagnetic (EM) wave changes and convert them into an electric signal due to the photoelectric effect. Depending on the requirements, scientists have found ways to develop photonic sensors based on several interesting platforms. In this work, we extensively review the most generally utilized photonic sensors for detecting vital environmental parameters and personal health care. These sensing systems include optical waveguides, optical fibers, plasmonics, metasurfaces, and photonic crystals. Various aspects of light are used to investigate the transmission or reflection spectra of photonic sensors. In general, resonant cavity or grating-based sensor configurations that work on wavelength interrogation methods are preferred, so these sensor types are mostly presented. We believe that this paper will provide insight into the novel types of available photonic sensors.
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Eletricidade , Fótons , Fibras Ópticas , TecnologiaRESUMO
Electroporation is a biophysical phenomenon involving an increase in cell membrane permeability to molecules after a high-pulsed electric field is applied to the tissue. Currently, electroporation is being developed for non-thermal ablation of cardiac tissue to treat arrhythmias. Cardiomyocytes have been shown to be more affected by electroporation when oriented with their long axis parallel to the applied electric field. However, recent studies demonstrate that the preferentially affected orientation depends on the pulse parameters. To gain better insight into the influence of cell orientation on electroporation with different pulse parameters, we developed a time-dependent nonlinear numerical model where we calculated the induced transmembrane voltage and pores creation in the membrane due to electroporation. The numerical results show that the onset of electroporation is observed at lower electric field strengths for cells oriented parallel to the electric field for pulse durations ≥10 µs, and cells oriented perpendicular for pulse durations ~100 ns. For pulses of ~1 µs duration, electroporation is not very sensitive to cell orientation. Interestingly, as the electric field strength increases beyond the onset of electroporation, perpendicular cells become more affected irrespective of pulse duration. The results obtained using the developed time-dependent nonlinear model are corroborated by in vitro experimental measurements. Our study will contribute to the process of further development and optimization of pulsed-field ablation and gene therapy in cardiac treatments.
Assuntos
Eletroporação , Dinâmica não Linear , Eletroporação/métodos , Terapia com Eletroporação , Eletricidade , Permeabilidade da Membrana CelularRESUMO
A common theme for the effect of electric field on the structure and conformation of proteins is lacking due to a myriad of conflicting reports emerging from different protein systems subjected to different frequencies and strengths of the field (0.8 -108 V cm-1), which may be pulsed for a few nano- to microseconds or applied continuously up to several hours. It is however necessary to find a common theme because of the increasing use of electric field not only to understand Stark-like electro-optic effects in large molecules but also in food processing technology, and perhaps in the disruption of amyloid bodies in Alzheimer's condition. This study finds an optimized condition of 1.3 V cm-1 DC field, in which the electrophoretic mobility is â¼1.2 mm h-1, and systematically shows electrophoretic, electrochemical, and unfolding effects at different levels of cytochrome c structure within â¼90 min of turning the field on. Interestingly, the protein undergoes amorphous aggregation concomitant with a high degree of denaturation. In support of this suggestion, data for myoglobin and trypsin are also presented. Effort has been made to separate out the chemical and physical effects of the electric field.
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Eletricidade , Mioglobina , Mioglobina/químicaRESUMO
In Mimosa pudica plants, local and global responses to environmental stimuli are associated with different types of electrical activity. Non-damaging stimuli (e.g. cooling) generate action potentials (APs), whereas damaging stimuli (e.g. heating) are associated with variation potentials (VPs). Local cooling of Mimosa branches resulted in APs that propagated up to the branch-stem interface and caused drooping of the branch (local response). This electrical activation did not pass the interface. If the branch was triggered by heat, however, a VP was transferred to the stem and caused activation of the entire plant (global response). VPs caused by heat were always preceded by APs and summation of the two types of activation appeared to be necessary for the activation to pass the branch-stem interface. Mechanical cutting of leaves also resulted in VPs preceded by APs, but in those cases a time delay was present between the two activations, which prevented adequate summation and transmission of activation. Simultaneous cold-induced activation of a branch and the stem below the interface occasionally resulted in summation sufficient to activate the stem beyond the interface. To investigate the effect of activation delay on summation, a similar structure of excitable converging pathways, consisting of a star-shaped pattern of neonatal rat heart cells, was used. In this model, summation of activation was not hindered by a small degree of asynchrony. The observations indicate that summation occurs in excitable branching structures and suggest that summation of activation plays a role in the propagation of nocuous stimuli in Mimosa.
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Mimosa , Animais , Ratos , Folhas de Planta/fisiologia , Plantas , Eletricidade , Potenciais de AçãoRESUMO
Recent advances in virtual reality (VR) technologies accelerate the creation of a flawless 3D virtual world to provide frontier social platform for human. Equally important to traditional visual, auditory and tactile sensations, olfaction exerts both physiological and psychological influences on humans. Here, we report a concept of skin-interfaced olfactory feedback systems with wirelessly, programmable capabilities based on arrays of flexible and miniaturized odor generators (OGs) for olfactory VR applications. By optimizing the materials selection, design layout, and power management, the OGs exhibit outstanding device performance in various aspects, from response rate, to odor concentration control, to long-term continuous operation, to high mechanical/electrical stability and to low power consumption. Representative demonstrations in 4D movie watching, smell message delivery, medical treatment, human emotion control and VR/AR based online teaching prove the great potential of the soft olfaction interface in various practical applications, including entertainment, education, human machine interfaces and so on.
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Olfato , Realidade Virtual , Humanos , Escolaridade , Eletricidade , EmoçõesRESUMO
This study intends to optimize the trading decision-making strategy of the new electricity market with virtual power plants and improve the transmission efficiency of electricity resources. The current problems in China's power market are analyzed from the perspective of virtual power plants, highlighting the necessity of reforming the power industry. The generation scheduling strategy is optimized in light of the market transaction decision based on the elemental power contract to enhance the effective transfer of power resources in virtual power plants. Ultimately, value distribution is balanced through virtual power plants to maximize the economic benefits. After 4 hours of simulation, the experimental data shows that 75 MWh of electricity is generated by the thermal power system, 100 MWh by the wind power system, and 200 MWh by the dispatchable load system. Comparatively, the new electricity market transaction model based on the virtual power plant has an actual generation capacity of 250MWh. In addition, the daily load power of the models of thermal power generation, wind power generation, and virtual power plant reported here are compared and analyzed. For a 4-hour simulation run, the thermal power generation system can provide 600 MW of load power, the wind power generation system can provide 730 MW of load power, and the virtual power plant-based power generation system can provide up to 1200 MW of load power. Therefore, the power generation performance of the model reported here is better than other power models. This study can potentially encourage a revised transaction model for the power industry market.
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Indústrias , Centrais Elétricas , Simulação por Computador , Vento , EletricidadeRESUMO
Corona ions from high voltage power lines (HVPL) can increase electrostatic charge on airborne pollutant particulates, possibly increasing received dose upon inhalation. To investigate the potential increased risk of childhood leukemia associated with residence near alternating current (AC) HVPL, we measured the particle charge state and atmospheric electricity parameters upwind, downwind and away from HVPL. Although we observed noticeable charge state alteration from background levels, most HVPL do not significantly increase charge magnitude. Particular HVPL types are shown to have most effect, increasing net charge to 15 times that at background. However, the magnitude of charge alteration during rainfall is comparable with the most extreme HVPL measurement. On current evidence, based on the current adult lung model, we suggest that although charge is sometimes enhanced to levels which may alter atmospheric particle dynamics, increased lung deposition is unlikely.
