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Channels (Austin) ; 11(5): 388-398, 2017 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-28636485

RESUMO

Renal sodium reabsorption depends on the activity of the Na+,K+-ATPase α/ß heterodimer. Four α (α1-4) and 3 ß (ß1-3) subunit isoforms have been described. It is accepted that renal tubule cells express α1/ß1 dimers. Aldosterone stimulates Na+,K+-ATPase activity and may modulate α1/ß1 expression. However, some studies suggest the presence of ß3 in the kidney. We hypothesized that the ß3 isoform of the Na+,K+-ATPase is expressed in tubular cells of the distal nephron, and modulated by mineralocorticoids. We found that ß3 is highly expressed in collecting duct of rodents, and that mineralocorticoids decreased the expression of ß3. Thus, we describe a novel molecular mechanism of sodium pump modulation that may contribute to the effects of mineralocorticoids on sodium reabsorption.


Assuntos
Túbulos Renais/metabolismo , Mineralocorticoides/farmacologia , ATPase Trocadora de Sódio-Potássio/metabolismo , Aldosterona/farmacologia , Animais , Linhagem Celular , Membrana Celular/metabolismo , Agonistas do Canal de Sódio Epitelial/farmacologia , Canais Epiteliais de Sódio/metabolismo , Masculino , Ratos Sprague-Dawley
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