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1.
Int Biomech ; 9(1): 1-9, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35929916

RESUMO

Tendons play a crucial role in the musculoskeletal system. In humans, tendon injuries, especially chronic tendinopathy, are very common and the patellar tendon is a frequent location for tendinopathy or injuries. The biomechanical characteristics of the patellar tendon, such as elasticity and stiffness, are of paramount importance and constitute major outcome measures in research studies. We aimed to assess whether the stiffness of the healthy ovine patellar tendon changes with age and weight in a population of normal animals. Sixty-eight 'patella-patellar tendon-tibial tuberosity' units from thirty-four Ile-de-France ewes of body mass 65 to 95 kg, euthanized for reasons other than musculoskeletal diseases, underwent a tensile test providing a measure of the tendon stiffness. Animals were sorted into three categories of age (1-2 yo, 3-5 yo, 6-10 yo). We found a positive but not significant correlation between age category and stiffness (r = 0.22, p = 0.27). There was a significantly positive correlation between weight and stiffness (r = 0.39, p = 0.04). In conclusion, the study characterized biomechanical properties of healthy tendons, provided useful reference values, and established the basis for future biomechanical tests on healing tendons in sheep. The most appropriate sheep population for those future studies would be non-overweight young adults presenting with no lameness.


Assuntos
Ligamento Patelar , Tendinopatia , Animais , Elasticidade , Feminino , França , Humanos , Ovinos , Tendões , Adulto Jovem
2.
Naturwissenschaften ; 109(4): 39, 2022 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-35913537

RESUMO

Records of chondrichthyan egg capsule morphotypes from the paralic deposits of the Belgian Coal Measures Group (Pennsylvanian; Bashkirian-Moscovian; Namurian B-Westphalian B according to the traditional subdivision) are presented and discussed. These include several species of the hybodontiform type Palaeoxyris as well as the putative holocephalian types Vetacapsula and Crookallia. Furthermore, the type specimens of Scapellites cottoni and S. minor, two additional putative and enigmatic egg capsules from the same lithostratigraphic unit, are figured and discussed. Altogether, a highly diverse egg capsule assemblage documented from the Belgian deposits implies the presence of at least eleven different Carboniferous chondrichthyan species using the ancient aquatic environments for spawning and as nurseries. The absence of the xenacanthiform morphotype Fayolia, known from surrounding coeval Coal Measures areas of northern France, the Netherlands, and Germany, is conspicuous. This lack may be a result of collecting bias and does not reflect a real pattern.


Assuntos
Carvão Mineral , Bélgica , França , Alemanha
3.
Soins ; 67(864): 25-26, 2022 Apr.
Artigo em Francês | MEDLINE | ID: mdl-35914874

RESUMO

Born in 1945 in the United States, the activity of home hospitalization (HH) did not stop developing in France after the 1950s. However, it was not recognized by the regulatory authorities and supervisory bodies until 1970. HH allows patients suffering from serious acute or chronic pathologies to continue to benefit seven days a week, twenty-four hours a day, at home, from technical and complex, frequent and coordinated care, inaccessible to city care. It is a central health policy issue in patient care.


Assuntos
Hospitais , França , Humanos
4.
Soins ; 67(864): 32-34, 2022 Apr.
Artigo em Francês | MEDLINE | ID: mdl-35914877

RESUMO

In France, advanced practice meets a need in the healthcare system. It is defined by six competencies that maximize those of the core profession. Its practice is regulated. In primary care, advanced practice nurses face certain difficulties, but the satisfaction of their partners should allow them to develop rapidly.


Assuntos
Prática Avançada de Enfermagem , Atenção à Saúde , França , Humanos , Atenção Primária à Saúde
5.
Soins ; 67(864): 60-64, 2022 Apr.
Artigo em Francês | MEDLINE | ID: mdl-35914886

RESUMO

Cardiovascular disease is the leading cause of death in the world and the second leading cause of death in France. Patients with coronary artery disease have a high risk of recurrence. Nevertheless, by acting on health determinants and secondary prevention, it is possible to reduce the risks. With the development of advanced nursing practice, a new professional with specific skills can take charge of and accompany people with this pathology. This player works in an interdisciplinary manner to provide holistic and optimal patient care.


Assuntos
Prática Avançada de Enfermagem , Doença da Artéria Coronariana , França , Humanos
6.
BMJ Open ; 12(8): e058799, 2022 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-35918108

RESUMO

OBJECTIVES: We aimed to quantify patient preferences for efficacy, safety and convenience features of atopic dermatitis (AD) treatments. DESIGN AND SETTING: Online discrete choice experiment survey. PARTICIPANTS: Adults in the UK, France and Spain who had used AD treatments during the past 2 years. PRIMARY AND SECONDARY OUTCOME MEASURES: Preferences for attributes were analysed using a multinomial logit model. Willingness to make trade-offs was expressed as the maximum acceptable decrease (MAD) in the probability of achieving clear/almost clear skin at week 16. RESULTS: The survey was completed by 404 patients (44.1±12.0 years; 65% women; 64% moderate/severe eczema). Most patients (68%) had no prior experience of using self-injectable treatments for AD or any other illness. Participants most valued increasing the chance of achieving a meaningful reduction in itch at week 16 from 20% to 50%, followed by reducing the risks of serious infections from 6% to 0% and of eye inflammation from 20% to 0%. Participants were willing to accept a decrease in the possibility of achieving clear/almost clear skin to obtain a treatment that can be paused (MAD=24.1%), requires occasional check-ups (MAD=16.1%) or no check-ups (MAD=20.9%) over frequent check-ups, is administered as a one time per day or two times per day oral pill versus a subcutaneous injection every 2 weeks (MAD=16.6%), has a 2-day over 2-week onset of action (MAD=11.3%), and can be used for flare management (MAD=5.8%). CONCLUSIONS: Although patients with AD most valued treatment benefits and risks, they were willing to tolerate reduced efficacy to obtain a rapid onset, oral administration, less frequent monitoring and a treatment that can be paused. Understanding patients' preferences for AD therapies, including new targeted therapies, can aid shared decision-making between clinicians and patients and support health technology assessments.


Assuntos
Dermatite Atópica , Preferência do Paciente , Adulto , Comportamento de Escolha , Dermatite Atópica/tratamento farmacológico , Feminino , França , Humanos , Masculino , Espanha , Reino Unido
7.
Commun Biol ; 5(1): 655, 2022 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-35788172

RESUMO

Economic impacts from plant pests are often felt at the regional scale, yet some impacts expand to the global scale through the alignment of a pest's invasion potentials. Such globally invasive species (i.e., paninvasives) are like the human pathogens that cause pandemics. Like pandemics, assessing paninvasion risk for an emerging regional pest is key for stakeholders to take early actions that avoid market disruption. Here, we develop the paninvasion severity assessment framework and use it to assess a rapidly spreading regional U.S. grape pest, the spotted lanternfly planthopper (Lycorma delicatula; SLF), to spread and disrupt the global wine market. We found that SLF invasion potentials are aligned globally because important viticultural regions with suitable environments for SLF establishment also heavily trade with invaded U.S. states. If the U.S. acts as an invasive bridgehead, Italy, France, Spain, and other important wine exporters are likely to experience the next SLF introductions. Risk to the global wine market is high unless stakeholders work to reduce SLF invasion potentials in the U.S. and globally.


Assuntos
Hemípteros , Vitis , Vinho , Animais , França , Humanos , Espécies Introduzidas
9.
Sci Data ; 9(1): 392, 2022 07 09.
Artigo em Inglês | MEDLINE | ID: mdl-35810155

RESUMO

We used a compiled data set from a monitoring network of oyster production coordinated by IFREMER (the French Research Institute for the Exploitation of the Sea). This network monitors the growth and mortality of the Pacific oyster Crassostrea gigas along French coasts since 1993. The archive, although publicly available, has been challenging to use due to changes in protocols and little information on metadata. Here, we describe data collection for almost 30 years, cleaning and processing. For 13 locations, we modeled growth and mortality of spat (less than one-year-old individuals) and half-grown oysters (between one and two-year-old individuals) as a function of time to cope with changes in data acquisition frequency, and produced standardized annual growth and cumulative mortality indicators to improve data usability. This improved database is expected to be used by ecologists interested in the evolution of life-cycle indicators of a marine species under the influence of climate change. It can also be valuable for epidemiologists because mortality data traces the emergence and spread of a massive epizootic.


Assuntos
Crassostrea , Animais , Crassostrea/crescimento & desenvolvimento , Bases de Dados Factuais , França , Fatores de Tempo
10.
Nutrients ; 14(13)2022 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-35807861

RESUMO

myfood24 is an innovative dietary assessment tool originally developed in English for use in the United Kingdom. This online 24 h recall, a tool commonly used in nutritional epidemiology, has been developed into different international versions. This paper aims to describe the creation of its French version. We used a consistent approach to development, aligned with other international versions, using similar methodologies. A nutritional database (food item codes, portion groups and accompaniments, etc.) was developed based on commonly used French food composition tables (CIQUAL 2017). Portion sizes were adapted to French dietary habits (estimation, photographs of French portion sizes, assessment of the photograph series and their angle (aerial vs. 45 degrees)). We evaluated the new tool, which contained nearly 3000 food items with 34 individuals using the System Usability Scale. We validated the French food portion picture series using EFSA criteria for bias and agreement. The results of the picture evaluation showed that the angle with which photos are taken had limited impact on the ability to judge portion size. Estimating food intake is a challenging task. Evaluation showed "good" usability of the system in its French version. myfood24 France will be a useful addition to nutritional epidemiology research in France.


Assuntos
Dieta , Avaliação Nutricional , Comportamento Alimentar , Alimentos , França , Humanos , Tamanho da Porção
11.
J Clin Virol ; 153: 105221, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35777223

RESUMO

OBJECTIVES: Viral respiratory infections are common in children, and usually associated with non-specific symptoms. Respiratory panel-based testing was implemented during the COVID-19 pandemic, for the rapid differentiation between SARS-CoV-2 and other viral infections, in children attending the emergency department (ED) of the teaching hospital of Lille, northern France, between February 2021 and January 2022. METHODS: Samples were collected using nasopharyngeal swabs. Syndromic respiratory testing was performed with two rapid multiplex molecular assays: the BioFire® Respiratory Panel 2.1 - plus (RP2.1 plus) or the QIAstat-Dx Respiratory SARS-CoV-2 Panel. SARS-CoV-2 variant was screened using mutation-specific PCR-based assays and genome sequencing. RESULTS: A total of 3517 children were included in the study. SARS-CoV-2 was detected in samples from 265 children (7.5%). SARS-CoV-2 infected patients were younger than those without SARS-CoV-2 infection (median age: 6 versus 12 months, p < 0.0001). The majority of infections (61.5%) were associated with the Omicron variant. The median weekly SARS-CoV-2 positivity rate ranged from 1.76% during the Alpha variant wave to 24.5% with the emergence of the Omicron variant. Most children (70.2%) were treated as outpatients, and seventeen patients were admitted to the intensive care unit. Other respiratory viruses were more frequently detected in SARS-CoV-2 negative children than in positive ones (82.1% versus 37.4%, p < 0.0001). Human rhinovirus/enterovirus and respiratory syncytial virus were the most prevalent in both groups. CONCLUSIONS: We observed a low prevalence of SARS-CoV-2 infection in children attending pediatric ED, despite the significant increase due to Delta and Omicron variants, and an important circulation of other respiratory viruses. Severe disease was overall rare in children.


Assuntos
COVID-19 , Infecções Respiratórias , Viroses , COVID-19/diagnóstico , COVID-19/epidemiologia , Serviço Hospitalar de Emergência , França , Humanos , Lactente , Pandemias , Infecções Respiratórias/diagnóstico , Infecções Respiratórias/virologia , SARS-CoV-2 , Viroses/diagnóstico
12.
Rev Infirm ; 71(281): 24-26, 2022 May.
Artigo em Francês | MEDLINE | ID: mdl-35843637

RESUMO

In France, the number of cancer survivors is expected to increase significantly in the coming years. However, there seems to be a lack of identification and management of complications after treatment. Coordination nurses and advanced practice nurses play a fundamental and complementary role to physicians in responding to this problem.


Assuntos
Sobreviventes de Câncer , Médicos , França , Humanos
13.
Rev Infirm ; 71(281): 38-40, 2022 May.
Artigo em Francês | MEDLINE | ID: mdl-35843643

RESUMO

It was in 2019 that the Equilibres nursing teams began to be deployed in three metropolitan regions: Hauts-de-France, Île-de-France and Occitanie. This organizational experiment, authorized by the Article 51 of the Social Insurance Financing Law, targets home nursing and mobilizes caregivers committed to patient autonomy and responsible regarding public health expenses.


Assuntos
Serviços de Assistência Domiciliar , Cuidadores , França , Humanos , Equipe de Enfermagem
14.
Nat Commun ; 13(1): 3942, 2022 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-35803909

RESUMO

In the COVID-19 pandemic many countries required COVID certificates, proving vaccination, recovery, or a recent negative test, to access public and private venues. We estimate their effect on vaccine uptake for France, Germany, and Italy using counterfactuals constructed via innovation diffusion theory. The announcement of COVID certificates during summer 2021 were associated - although causality cannot be directly inferred - with increased vaccine uptake in France of 13.0 (95% CI 9.7-14.9) percentage points (p.p.) of the total population until the end of the year, in Germany 6.2 (2.6-6.9) p.p., and in Italy 9.7 (5.4-12.3) p.p. Based on these estimates, an additional 3979 (3453-4298) deaths in France, 1133 (-312-1358) in Germany, and 1331 (502-1794) in Italy were averted; and gross domestic product (GDP) losses of €6.0 (5.9-6.1) billion in France, €1.4 (1.3-1.5) billion in Germany, and €2.1 (2.0-2.2) billion in Italy were prevented. Notably, in France, the application of COVID certificates averted high intensive care unit occupancy levels where prior lockdowns were instated.


Assuntos
COVID-19 , Vacinas , COVID-19/epidemiologia , COVID-19/prevenção & controle , Controle de Doenças Transmissíveis , França/epidemiologia , Alemanha/epidemiologia , Humanos , Itália/epidemiologia , Avaliação de Resultados em Cuidados de Saúde , Pandemias/prevenção & controle
15.
Artigo em Inglês | MEDLINE | ID: mdl-35805399

RESUMO

This study aims to describe the socio-demographic profile of so-called "key workers" during the first lockdown in France and to assess their potential occupational exposure to SARS-CoV-2 under routine, pre-pandemic working conditions. We used the French list of essential jobs that was issued during the first lockdown to identify three subgroups of key workers (hospital healthcare, non-hospital healthcare, non-healthcare). Based on the population-based "Conditions de travail-2019" survey, we described the socio-demographic composition of key workers and their potential work-related exposures (to "infectious agents," "face-to-face contact with the public," and "working with colleagues") using modified Poisson regression. In general, women, clerical and manual workers, workers on temporary contracts, those with lower education and income, and non-European immigrants were more likely to be key workers, who accounted for 22% of the active population. Non-healthcare essential workers (57%) were the most socially disadvantaged, while non-hospital healthcare workers (19%) were polarized at both extremes of the social scale; hospital healthcare workers (24%) were intermediate. Compared to non-key workers, all subgroups had greater exposure to infectious agents and more physical contact with the public. This study provides evidence of accumulated disadvantages among key workers concerning their social background, geographical origin, and potential SARS-CoV-2 exposure.


Assuntos
COVID-19 , Exposição Ocupacional , COVID-19/epidemiologia , Controle de Doenças Transmissíveis , Demografia , Feminino , França/epidemiologia , Pessoal de Saúde , Humanos , RNA Viral , SARS-CoV-2
16.
BMC Psychiatry ; 22(1): 477, 2022 07 16.
Artigo em Inglês | MEDLINE | ID: mdl-35842596

RESUMO

BACKGROUND: Social withdrawal (hikikomori) has become an internationally recognized phenomenon, but its pathology and related factors are not yet fully known. We previously conducted a statistical case-control study on adolescent patients with hikikomori in Japan, which revealed the non-specificity of pathology in patients with hikikomori. Further, environmental factors, such as the lack of communication between parents and Internet overuse, were found to be significant predictors of hikikomori severity. Here, we aimed to conduct a similar preliminary case-control study in France and to compare the results with those from the study conducted in Japan. METHODS: Parents of middle school students who underwent psychiatric outpatient treatment for hikikomori (n = 10) and control group parents (n = 115) completed the Child Behavior Checklist to evaluate their child's psychopathological characteristics and the Parental Assessment of Environment and Hikikomori Severity Scales, as in our previous study in Japan. We compared the descriptive statistics and intergroup differences in France with those from the previous study conducted in Japan. In the multiple regression analysis to find predictors of hikikomori severity in French and also Japanese subjects, the same dependent and independent variables were chosen for the present study (both differed from the previous study). These were used in order to make accurate intercountry comparisons. RESULTS: The comparisons revealed no differences in the pathology of hikikomori between Japan and France. Specifically, both studies found similarly increased scores for all symptom scales, with no specific bias. However, the statistical predictors of hikikomori severity in France (lack of communication between parents and child and lack of communication with the community) differed from those in Japan (lack of communication between parents). CONCLUSION: Hikikomori in Japan and France could be considered essentially the same phenomenon; moreover, our findings demonstrated the universal non-specificity and unbiasedness of the hikikomori pathology. This suggests that hikikomori is not a single clinical category with a specific psychopathology; instead, it is a common phenotype with various underlying pathologies. However, different strategies may be required in each country to prevent the onset and progression of hikikomori.


Assuntos
Transtornos Mentais , Isolamento Social , Estudos de Casos e Controles , França , Humanos , Japão , Transtornos Mentais/psicologia , Fobia Social , Vergonha , Isolamento Social/psicologia
17.
BMC Geriatr ; 22(1): 602, 2022 07 20.
Artigo em Inglês | MEDLINE | ID: mdl-35858861

RESUMO

BACKGROUND: There are few studies reporting on self-medication, perceptions or difficulties older adults have with their medications. This study aimed to describe the uses and the perceptions of medications among older adults in France and to identify patient groups based on that information. METHODS: We used data from the 2020 'French Health Barometer' - a nationally-representative cross-sectional survey. We assessed polypharmacy (five or more medications), self-medication, and patient perceptions of medications. Robust Poisson regression was used to investigate socio-demographic and health-related factors associated with the outcomes. Latent class analysis was used to identify patient groups classified by the use and the perceptions of medications. Factors associated with group assignment were investigated by multinomial logistic regression. All analyses were weighted. RESULTS: The study sample comprised 1,623 respondents aged 70-85 years. Polypharmacy and self-medication were reported in 23.5 and 48.7% of the older population, respectively. Polypharmacy was associated with increasing age, low education, and impaired health status. Self-medication was associated with female sex and high education. Among individuals taking at least 1 medication, 8.2% reported not to understand all their medications, and 9.7% having difficulty taking medications as prescribed. Among individuals taking at least 2 medications, 23.2% thought that they took too many medications. Three patient groups were identified: 'Non-polypharmacy, positive perceptions' (62.5%), 'Polypharmacy, positive perceptions' (28.0%), and 'Negative perceptions' (9.5%). CONCLUSIONS: Polypharmacy and self-medication are common in French older adults. One segment of people reported negative perceptions of their medications regardless of their polypharmacy status. This underlines the difference between the objective and perceived measures of polypharmacy.


Assuntos
Polimedicação , Automedicação , Idoso , Estudos Transversais , Feminino , França/epidemiologia , Inquéritos Epidemiológicos , Humanos
18.
PLoS One ; 17(7): e0270641, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35797376

RESUMO

African swine fever (ASF) is an infectious disease of domestic and wild pigs of all breeds and ages, with the acute form of the disease being characterized by high fever, hemorrhages in the reticuloendothelial system and a high mortality rate. Registered safe and efficacious ASF vaccines are not available. The development of experimental ASF vaccines, particularly live attenuated, have considerably intensified in the last years. There is much variability in experimental approaches undertaken by laboratories attempting to develop first generation vaccines, rendering it difficult to interpret and make comparisons across trials. ASF virus (ASFV) genotyping does not fully correlate with available cross-protection data and may be of limited value in predicting cross-protective vaccine efficacy. Recently, ASFV strains were assigned to a respective nine groups by seroimmunotype (from I to IX): in vivo the grouping is based on results of cross protection of pigs survived after their infection with a virulent strain (bioassay), while in vitro this grouping is based on hemadsorption inhibition assay (HADIA) data. Here we demonstrate the antigenic and protective properties of two attenuated ASFV strains MK200 and FK-32/135. Pronounced differences in the HADIA and in immunological test in animals allow us to consider them and the corresponding reference virulent strains of the ASFV of Mozambique-78 (seroimmunotype III, genotype V) and France-32 (seroimmunotype IV, genotype I) as useful models for studying the mechanisms of protective immunity and evaluation of the candidate vaccines.


Assuntos
Vírus da Febre Suína Africana , Febre Suína Africana , Vacinas Virais , Animais , França , Genótipo , Macrófagos , Suínos
19.
Int J Public Health ; 67: 1604562, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35859669

RESUMO

Objectives: We aimed to examine social inequalities in participation in cervical cancer screening (CCS) in a metropolitan area by implementing a pilot organised screening programme. The pilot programme consisted of sending invitations to women who did not perform a pap smear within the past 3 years, managing interventions to reach vulnerable women, training healthcare professionals, and organising follow-ups of abnormal pap smears. Methods: We studied participation in CCS between January 2014 and December 2016 among 241,257 women aged 25-63 years old. To assess relative inequalities, Odds Ratios were computed using multilevel logistic regression. To assess absolute inequalities, the CCS coverage and the rate difference were calculated. Inequalities were computed by age and neighbourhood characteristics (social deprivation and proportion of single women). Results: Disparities in participation in CCS were observed by age and social deprivation. For overall screening compared to opportunistic screening, disparities by age were larger (OR25-35_vs._55-64 = 2.13 [2.08-2.19] compared to 2.02 [1.96-2.07]), but disparities by social deprivation were decreased (OR10%_most_vs._10%_least_deprived = 2.09 [1.90-2.30] compared to 2.22 [2.02-2.44]). Conclusion: Disparities in CCS participation remain despite the organised programme. To reduce these inequalities, free screening should be proposed and evaluated.


Assuntos
Detecção Precoce de Câncer , Neoplasias do Colo do Útero , Adulto , Feminino , França , Humanos , Pessoa de Meia-Idade , Paris , Fatores Socioeconômicos , Neoplasias do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/prevenção & controle
20.
Artigo em Inglês | MEDLINE | ID: mdl-35897478

RESUMO

(1) Background: The effects of lockdown repetition on work-related stress, expressed through Effort-Reward Imbalance (ERI), during the COVID-19 pandemic are poorly documented. We investigated the effect of repetitive lockdowns on the ERI in French workers, its difference across occupations, and the change in its influencing factors across time. (2) Methods: Participants were included in a prospective cross-sectional observational study from 30 March 2020 to 28 May 2021. The primary outcome was the ERI score (visual analog scale). The ERI score of the population was examined via Generalized Estimating Equations. For each period, the factors influencing ERI were studied by multivariate linear regression. (3) Results: In 8121 participants, the ERI score decreased in the first 2 lockdowns (53.2 ± 0.3, p < 0.001; 50.5 ± 0.7, p < 0.001) and after lockdown 2 (54.8 ± 0.8, p = 0.004) compared with the pre-pandemic period (59 ± 0.4). ERI was higher in medical than in paramedical professionals in the pre-pandemic and the first 2 lockdowns. Higher workloads were associated with better ERI scores. (4) Conclusions: In a large French sample, Effort-Reward Imbalance worsened during the COVID-19 pandemic until the end of the 2nd lockdown. Paramedical professionals experienced a higher burden of stress compared with medical professionals.


Assuntos
COVID-19 , Pandemias , COVID-19/epidemiologia , Controle de Doenças Transmissíveis , Estudos Transversais , França/epidemiologia , Humanos , Satisfação no Emprego , Estudos Prospectivos , Recompensa , Estresse Psicológico/epidemiologia , Inquéritos e Questionários , Carga de Trabalho
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