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Orthop Nurs ; 41(5): 317, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36166605
Lancet ; 399(10338): 1853, 2022 05 14.
Artigo em Inglês | MEDLINE | ID: mdl-35569450
Zhongguo Zhong Yao Za Zhi ; 47(5): 1415-1420, 2022 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-35343171


This study mainly introduced the research on Chinese medicine toxicology funded by the National Natural Science Foundation of China(NSFC) in 2012-2021 and analyzed the research content. Furthermore, key research topics and characteristic research projects were discussed, such as the toxicity mechanism, relationship between toxicity and efficacy, toxicity-alleviating mechanisms, and new technology and methods. The review suggested that researchers should gain an in-depth understanding of the "toxicity" of Chinese me-dicine, turned to characteristic research topics, and build a toxicological research paradigm suited to the characteristics of Chinese medicine in project application.

Fundações , Disciplinas das Ciências Naturais , China , Medicina Tradicional Chinesa
PLoS One ; 17(2): e0264070, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35213595


Under the current universal trend towards larger grant sizes in research funding systems, we focus on how large of a grant size is appropriate. We study the directional returns to scale (RTS) to assess whether current grant sizes are the most productive. We take the General Program of the National Natural Science Foundation of China (NSFC) as an example and select three samples of physics, geography and management for an empirical study. We find that the optimal input direction and the most productive grant size scale is different for the three disciplines; based on the current grant size, physics should not expand the grant size and team size input, geography should further increase the grant size to improve performance and management should further expand the team size rather than the grant size. In this paper, we demonstrate a new method to calculate the optimal direction, which is the lowest rate of congestion, according to the characteristics of the General Program. Based on these results, we also calculate the most productive scale size. This method has certain value for project management.

Organização do Financiamento/economia , Fundações/economia , Disciplinas das Ciências Naturais/economia , Apoio à Pesquisa como Assunto/economia , China
Zhongguo Zhong Yao Za Zhi ; 47(1): 253-258, 2022 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-35178931


Through a retrospective analysis of the projects supported by the National Natural Science Foundation of China in the past ten years in the field of Chinese medicine for the treatment of malignant tumors, this article systematically summarized the main research contents and hotspots of Chinese medicine in efficacy enhancement and toxicity reduction. The efficacy enhancement of Chinese medicine mainly included the mitigation of molecule-targeted drug resistance, multidrug resistance, and chemotherapy resistance, synergistic efficacy enhancement, and radiotherapy sensitization. The toxicity reduction is mainly reflected in the alleviation of the side effects of radiotherapy and chemotherapy. In addition, Chinese medicine has advantages in reducing serious adverse reactions of malignant tumors, providing more options for the adjuvant treatment of tumors.

Disciplinas das Ciências Naturais , Neoplasias , China , Fundações , Humanos , Medicina Tradicional Chinesa , Neoplasias/tratamento farmacológico , Estudos Retrospectivos
Zhonghua Yan Ke Za Zhi ; 58(5): 360-370, 2022 May 11.
Artigo em Chinês | MEDLINE | ID: mdl-35078305


Objective: To review the application for funding of ophthalmologic projects from the National Natural Science Foundation of China (NSFC) and the current research progress, and to provide reference for the promotion of basic eye research in China. Methods: The NSFC application and funding information of ophthalmology-related projects from 2010 to 2021 were collected as a database for further analysis. The main categories of the analysis included the number of application and funding, the funding ratio, the research directions and the funded organizations. Results: During the 12 years, 13 267 applications were received in the field of ophthalmology, with an increase of 157.21% (1 025/652) in 2021 compared with 2010, and the number of applications for the Youth Foundation grew significantly. There were 2 221 funded projects, with an increase of 81.51% (97/119) in 2021 compared with 2010. After 2017, the number of funded projects was basically around 200 per year, with a funding rate of 16.74%(2 221/13 267). The funding amount was 1 026.9 million yuan in total, with an average of 462 400 yuan. Sun Yat-sen University (1 060 applied and 265 funded projects), Fudan University (759 applied and 186 funded projects), Shanghai Jiaotong University (820 applied and 178 funded projects), Wenzhou Medical University (625 applied and 113 funded projects) and Capital Medical University (538 applied and 95 funded projects) were the top five institutions in terms of the number of application and funding. Conclusions: From 2010 to 2021, the application number of ophthalmology projects increased rapidly, while the number of funded projects increased slowly, and the funding ratio decreased year by year. With the support of NSFC, the basic research of ophthalmology in China has made great progress. However, we still need to find and solve problems to promote the sustainable advance of ophthalmology. (This article was published ahead of print on the official website of Chinese Journal of Ophthalmology on January 21, 2022).

Disciplinas das Ciências Naturais , Oftalmologia , Adolescente , China , Análise de Dados , Fundações , Humanos
Curr Med Sci ; 42(2): 453-461, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35089494


OBJECTIVE: This study explains the application number and funding rate of oncology projects undertaken by the National Natural Science Foundation of China (NSFC), with focus on tumor radiotherapy-related research over the past 11 years. METHODS: A stratified analysis was carried out on the application and funding status of tumor radiotherapy studies in different NSFC project categories, different research areas, and different tumor types. Research areas that required specific focus, such as immunology-related radiotherapy, multimodality imaging and radiomics, and post-radiotherapy organ injury, were separately analyzed. RESULTS: The status and development trends of various related research fields were studied, and the research results were presented with the support of the NSFC, in order to provide reference for future applications and funding allocations. CONCLUSION: The number of applications for funding increases every year. Although the total number of funded projects has also increased every year, the funding rate has decreased year by year. Projects on radiotherapy and immunization have been at the forefront in recent years, and the funding rate for these projects increases yearly.

Disciplinas das Ciências Naturais , Neoplasias , China , Fundações , Humanos , Neoplasias/radioterapia
Indian J Med Ethics ; VII(1): 1-4, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34730103


Is the lack of action by the World Health Organization (WHO) against the growing global obesity and diabetes epidemics influenced by the Bill and Melinda Gates Foundation's pharmaceutical investments and knowledge creation? Diabetes Type-2 is increasing globally and is a serious health risk.

Fundações , Saúde Global , Humanos
Am J Obstet Gynecol ; 226(2S): S1254-S1264.e1, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-34479720


Preeclampsia is a disease exclusive to pregnancy and the immediate postpartum period, occurring in 4.6% of pregnancies worldwide. Preeclampsia and other gestational hypertensive disorders can affect any pregnant woman. The consequences of developing this disease can lead to severe maternal and neonatal morbidities and mortalities, including fetal growth restriction, placental abruption, preterm birth, stillbirth, and maternal death. When pregnant women recover, they are at higher risk of long-term complications such as hypertension, stroke, heart failure, renal disease, and Alzheimer disease. The consequences extend to the offspring because they are at higher risk of cardiovascular diseases, and female offspring are at greater risk of developing preeclampsia when they become pregnant. For society, preeclampsia presents an economic burden related to the additional healthcare costs associated with low birthweight, prematurity, and adverse outcomes to the mother and baby. This article shares the unique perspective of affected women and their families, the effect preeclampsia has on us, and what we hope the healthcare system can deliver for our sisters and daughters in the future. Patients and their families established the Preeclampsia Foundation 21 years ago. Devoted to education and patient advocacy to raise awareness, improve healthcare practices, and catalyze research, we share some of the Foundation's realized strategies and achievements. We tell you our stories and struggles, and we issue a call to action for all stakeholders to help fulfill our vision for a world where hypertensive disorders of pregnancy no longer threaten the lives of mothers and their babies.

Fundações , Pré-Eclâmpsia , Feminino , Humanos , Narração , Defesa do Paciente , Educação de Pacientes como Assunto , Gravidez , Sistema de Registros , Apoio à Pesquisa como Assunto , Apoio Social
BMC Pregnancy Childbirth ; 21(1): 805, 2021 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-34863125


BACKGROUND: To evaluate the performance of the Fetal Medicine Foundation (FMF) preterm preeclampsia (PE) screening algorithm in an indigenous South Asian population. METHODS: This was a prospective observational cohort study conducted in a tertiary maternal fetal unit in Delhi, India over 2 years. The study population comprised of 1863 women carrying a singleton pregnancy and of South Asian ethnicity who were screened for preterm pre-eclampsia (PE) between 11 and 14 weeks of gestation using Mean Arterial Pressure (MAP), transvaginal Mean Uterine Artery Pulsatility Index (UtAPI) and biochemical markers - Pregnancy Associated Plasma Protein-A (PAPP-A) and Placental Growth Factor.. Absolutemeasurements of noted biomarkers were converted to multiples of the expected gestational median (MoMS) which were then used to estimate risk for preterm PE < 37 weeks using Astraia software. Women with preterm PE risk of ≥1:100 was classified as as high risk. Detection rates (DR) at 10% false positive rate were calculated after adjusting for prophylactic aspirin use (either 75 or 150 mg). RESULTS: The incidence of PE and preterm PE were 3.17% (59/1863) and 1.34% (25/1863) respectively. PAPP-A and PlGF MoM distribution medians were 0.86 and 0.87 MoM and significantly deviated from 1 MoM. 431 (23.1%) women had a risk of ≥1:100, 75 (17.8%) of who received aspirin. Unadjusted DR using ≥1:100 threshold was 76%.Estimated DRs for a fixed 10% FPR ranged from 52.5 to 80% depending on biomarker combination after recentering MoMs and adjusting for aspirin use. CONCLUSION: The FMF algorithm whilst performing satisfactorily could still be further improved to ensure that biophysical and biochemical markers are correctly adjusted for indigenous South Asian women.

Algoritmos , Programas de Rastreamento/métodos , Pré-Eclâmpsia/diagnóstico , Pré-Eclâmpsia/etnologia , Primeiro Trimestre da Gravidez , Pressão Arterial/fisiologia , Biomarcadores , Estudos de Coortes , Feminino , Fundações , Humanos , Índia/etnologia , Perinatologia , Fator de Crescimento Placentário/metabolismo , Gravidez , Proteína Plasmática A Associada à Gravidez/metabolismo , Estudos Prospectivos , Fluxo Pulsátil/fisiologia , Risco
Nature ; 600(7890): 606, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34934199

Fundações , Humanos
Rev. medica electron ; 43(5): 1328-1344, 2021. tab, graf
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1352114


RESUMEN Introducción: la violencia es un fenómeno psicosocial, considerado un problema de salud pública que genera graves consecuencias en las mujeres. La dependencia emocional podría ser un factor esencial para que una mujer tolere situaciones de violencia. Objetivo: determinar la relación entre la dependencia emocional y la violencia en mujeres atendidas en la Fundación Nosotras con Equidad, de Riobamba, Ecuador. Materiales y métodos: se realizó un estudio observacional, prospectivo, transversal, analítico, bivariado y de nivel relacional, en una población de 300 mujeres de 18 a 65 años de la Fundación Nosotras con Equidad, de Riobamba, durante el primer semestre de 2020. Para el procesamiento de datos de dependencia emocional y violencia se utilizó el programa IBM SPSS Statistics 25.0; para el análisis estadístico-descriptivo gráficos de barras agrupadas, y para el análisis bivariado el coeficiente de correlación tau-b de Kendall. Resultados: se evidenció que 237 mujeres presentaron dependencia emocional moderada (79,0 %) y que 279 indicaron haber sufrido violencia de pareja severa (93,0%). La correlación entre la dependencia emocional y la violencia psicológica es media positiva (0.473). Conclusiones: en las mujeres víctimas de violencia se hallaron altos niveles de dependencia emocional y se evidenció una correlación media positiva entre la violencia psicológica y la dependencia emocional. En la variable de dependencia emocional se observaron como indicadores relevantes el miedo a la soledad, a ser abandonada, lo que representa una forma de rechazo a su autoestima, manteniéndose sumergida en una relación violenta (AU).

ABSTRACT Introduction: violence is a psychosocial phenomenon, considered a public health problem that generates serious consequences for women. Emotional dependence could be an important factor for a woman to tolerate situations of violence. Objective: to determine the relationship between emotional dependence and violence in women attended at the FundaciónNosotras con Equidad, of Riobamba, Ecuador. Materials and methods: an observational, prospective, cross-sectional, analytical, bivariate and relational study was conducted in a population of 300 women aged 18 to 65 years from the FundaciónNosotras con Equidad, of Riobamba, during the first semester of 2020. The IBM SPSS Statistics 25.0 program was used for processing emotional dependence and violence data; for statistical-descriptive analysis, grouped bar graphs, and for bivariate analysis, the correlation coefficient tau-b of Kendall. Results: it was shown that 237 women had moderate emotional dependence (79.0%) and 279 reported that they had suffered severe partner violence (93.0%). The correlation between emotional dependence and psychological violence is average positive (0.473). Conclusions: high levels of emotional dependence were found in women victims of violence and an average positive correlation between psychological violence and emotional dependence was evident. In the variable of emotional dependence, the fear of loneliness, of being abandoned, was observed as relevant indicators, which represents a form of rejection of their self-esteem, remaining immersed in a violent relationship (AU).

Humanos , Masculino , Feminino , Dependência Psicológica , Violência contra a Mulher , Mulheres , Organização Mundial da Saúde , Impacto Psicossocial , Fundações/normas , Fundações/tendências