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1.
Sci Rep ; 14(1): 21910, 2024 09 19.
Artigo em Inglês | MEDLINE | ID: mdl-39300159

RESUMO

Severe Neonatal Jaundice (SNJ) causes long-term neurocognitive impairment, cerebral palsy, auditory neuropathy, deafness, or death. We developed a mathematical model for allo-hemodialysis as a potential blood purification method for the treatment of SNJ in term or near-term infants. With allo-hemodialysis (allo-HD), the neonate's blood flows through hollow fibers of a miniature 0.075 m2 hemodialyzer, while the blood of a healthy adult ("buddy") flows counter-currently through the dialysate compartment. We simulated the kinetics of unconjugated bilirubin in allo-hemodialysis with neonate blood flow rates of 12.5 and 15 mL/min (for a 2.5 kg and 3.5 kg neonate, respectively), and 30 mL/min for the buddy. Bilirubin production rates in neonate and buddy were set to 6 and 3 mg/kg/day, respectively. Buddy bilirubin conjugation rate was calculated to obtain normal steady-state bilirubin levels. Albumin levels were set to 1.1, 2.1, 3.1 g/dL for the neonate and 3.3 g/dL for the buddy. Model simulations suggest that a 6-h allo-hemodialysis session could reduce neonatal bilirubin levels by > 35% and that this modality would be particularly effective with low neonatal serum albumin levels. Due to the high bilirubin conjugation capacity of an adult's healthy liver and the larger distribution volume, the buddy's bilirubin level increases only transiently during allo-hemodialysis. Our modelling suggests that a single allo-hemodialysis session may lower neonatal unconjugated bilirubin levels effectively. If corroborated in ex-vivo, animal, and clinical studies, this bilirubin reduction could lower the risks associated with SNJ, especially kernicterus, and possibly avoiding the morbidity associated with exchange transfusions.


Assuntos
Bilirrubina , Icterícia Neonatal , Diálise Renal , Humanos , Recém-Nascido , Bilirrubina/sangue , Bilirrubina/metabolismo , Icterícia Neonatal/terapia , Icterícia Neonatal/sangue , Diálise Renal/métodos , Diálise Renal/efeitos adversos , Modelos Teóricos
2.
Sensors (Basel) ; 24(18)2024 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-39338900

RESUMO

Bilirubin is a product of the metabolism of hemoglobin from red blood cells. Higher levels of bilirubin are a sign that either there is an unusual breaking down rate of red blood cells or the liver is not able to eliminate bilirubin, through bile, into the gastrointestinal tract. For adults, bilirubin is occasionally monitored through urine or invasive blood sampling, whilst all newborns are routinely monitored visually, or non-invasively with transcutaneous measurements (TcBs), due to their biological immaturity to conjugate bilirubin. Neonatal jaundice is a common condition, with higher levels of unconjugated bilirubin concentration having neurotoxic effects. Actual devices used in TcBs are focused on newborn populations, are hand-held, and, in some cases, operate in only two wavelengths, which does not necessarily guarantee reliable results over all skin tones. The same occurs with visual inspections. Based on that, a continuous bilirubin monitoring device for newborns is being developed to overcome visual inspection errors and to reduce invasive procedures. This device, operating optically with a mini-spectrometer in the visible range, is susceptible to patient movements and, consequently, to situations with a lower signal quality for reliable bilirubin concentration estimates on different types of skin. Therefore, as an intermediate development step and, based on skin spectra measurements from adults, this work addresses the device's placement status prediction as a signal quality indication index. This was implemented by using machine learning (ML), with the best performances being achieved by support vector machine (SVM) models, based on the spectra acquired on the arm and forehead areas.


Assuntos
Bilirrubina , Pele , Humanos , Bilirrubina/sangue , Bilirrubina/análise , Recém-Nascido , Pele/química , Pele/metabolismo , Adulto , Icterícia Neonatal/sangue , Icterícia Neonatal/diagnóstico , Monitorização Fisiológica/métodos
3.
Medicina (Kaunas) ; 60(9)2024 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-39336532

RESUMO

Background and Objectives: To evaluate the clinical findings of glucose 6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PK) deficiency in prolonged jaundice and to determine whether the systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) can be used in the diagnosis of neonatal prolonged jaundice. Materials and Methods: Among full-term neonates with hyperbilirubinemia who were admitted to Medicine Hospital between January 2019 and January 2024 with the complaint of jaundice, 167 infants with a serum bilirubin level above 10 mg/dL, whose jaundice persisted after the 10th day, were included in this study. Results: G6PD activity was negatively correlated with NLR, SII, age, and hematocrit (Hct). There was a weak negative correlation between G6PD and NLR and a moderate negative correlation between G6PD activity and SII when adjusted for age and Hct. PK activity showed no significant correlation with G6PD, NLR, PLR, SII, age, and Hct. A linear relationship was observed between G6PD activity and SII and NLR. Conclusions: NLR and SII can be easily calculated in the evaluation of prolonged jaundice in G6PD deficiency has a considerable advantage. NLR and SII levels may contribute by preventing further tests for prolonged jaundice and regulating its treatment. It may be useful to form an opinion in emergencies and in early diagnostic period.


Assuntos
Biomarcadores , Glucosefosfato Desidrogenase , Inflamação , Icterícia Neonatal , Piruvato Quinase , Humanos , Icterícia Neonatal/sangue , Icterícia Neonatal/diagnóstico , Piruvato Quinase/sangue , Piruvato Quinase/deficiência , Piruvato Quinase/análise , Recém-Nascido , Biomarcadores/sangue , Feminino , Masculino , Inflamação/sangue , Glucosefosfato Desidrogenase/sangue , Deficiência de Glucosefosfato Desidrogenase/sangue , Deficiência de Glucosefosfato Desidrogenase/complicações , Deficiência de Glucosefosfato Desidrogenase/diagnóstico , Erros Inatos do Metabolismo dos Piruvatos/sangue , Erros Inatos do Metabolismo dos Piruvatos/complicações , Neutrófilos , Anemia Hemolítica Congênita não Esferocítica
4.
Int J Mol Sci ; 25(16)2024 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-39201270

RESUMO

Jaundice is a symptom of high blood bilirubin levels affecting about 80% of neonates. In neonates fed with breast milk, jaundice is particularly prevalent and severe, which is likely multifactorial. With the development of genomics and metagenomics, a deeper understanding of the neonatal gut microbiota has been achieved. We find there are accumulating evidence to indicate the importance of the gut microbiota in the mechanism of jaundice. In this paper, we present new comprehensive insight into the relationship between the microbiota and jaundice. In the new perspective, the gut is a crucial crossroad of bilirubin excretion, and bacteria colonizing the gut could play different roles in the excretion of bilirubin, including Escherichia coli as the main traffic jam causers, some Clostridium and Bacteroides strains as the traffic police, and most probiotic Bifidobacterium and Lactobacillus strains as bystanders with no effect or only a secondary indirect effect on the metabolism of bilirubin. This insight could explain why breast milk jaundice causes a longer duration of blood bilirubin and why most probiotics have limited effects on neonatal jaundice. With the encouragement of breastmilk feeding, our perspective could guide the development of new therapy methods to prevent this side effect of breastfeeding.


Assuntos
Bilirrubina , Microbioma Gastrointestinal , Icterícia Neonatal , Probióticos , Humanos , Icterícia Neonatal/terapia , Icterícia Neonatal/microbiologia , Icterícia Neonatal/etiologia , Recém-Nascido , Bilirrubina/metabolismo , Bilirrubina/sangue , Aleitamento Materno , Leite Humano/microbiologia , Leite Humano/metabolismo
5.
Gut Microbes ; 16(1): 2388805, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39166704

RESUMO

Early identification of neonatal jaundice (NJ) appears to be essential to avoid bilirubin encephalopathy and neurological sequelae. The interaction between gut microbiota and metabolites plays an important role in early life. It is unclear whether the composition of the gut microbiota and metabolites can be used as an early indicator of NJ or to aid clinical decision-making. This study involved a total of 196 neonates and conducted two rounds of "discovery-validation" research on the gut microbiome-metabolome. It utilized methods of machine learning, causal inference, and clinical prediction model evaluation to assess the significance of gut microbiota and metabolites in classifying neonatal jaundice (NJ), as well as the potential causal relationships between corresponding clinical variables and NJ. In the discovery stage, NJ-associated gut microbiota, network modules, and metabolite composition were identified by gut microbiome-metabolome association analysis. The NJ-associated gut microbiota was closely related to bile acid metabolites. By Lasso machine learning assessment, we found that the gut bacteria were associated with abnormal bile acid metabolism. The machine learning-causal inference approach revealed that gut bacteria affected serum total bilirubin and NJ by influencing bile acid metabolism. NJ-associated gut bile acids are potential biomarkers of NJ, and clinical prediction models constructed based on these biomarkers have some clinical effects and the model may be used for disease risk prediction. In the validation stage, it was found that intestinal metabolites can predict NJ, and the machine learning-causal inference approach revealed that bile acid metabolites affected NJ itself by affecting the total bilirubin content. Intestinal bile acid metabolites are potential biomarkers of NJ. By applying machine learning-causal inference methods to gut microbiome-metabolome association studies, we found NJ-associated intestinal bacteria and their network modules and bile acid metabolite composition. The important role of intestinal bacteria and bile acid metabolites in NJ was determined, which can predict the risk of NJ.


Association analysis of the intestinal microbiome-metabolome found that neonatal jaundice (NJ)-related intestinal microbiota, network modules and metabolite composition, and the intestinal microbiota are closely related to bile acid metabolites.Gut bacteria were found to affect serum total bilirubin (TBIL) and NJ by influencing bile acid metabolism through a machine learning-causal inference approach, and bile acid metabolites affected NJ itself by affecting the TBIL content.NJ-associated gut bacteria and bile acids are potential biomarkers of NJ, and clinical decision-making models based on these biomarkers have some clinical effects for disease risk prediction.


Assuntos
Bactérias , Ácidos e Sais Biliares , Microbioma Gastrointestinal , Icterícia Neonatal , Aprendizado de Máquina , Humanos , Recém-Nascido , Ácidos e Sais Biliares/metabolismo , Bactérias/classificação , Bactérias/metabolismo , Bactérias/isolamento & purificação , Bactérias/genética , Icterícia Neonatal/metabolismo , Icterícia Neonatal/microbiologia , Feminino , Masculino , Biomarcadores/metabolismo , Metaboloma , Bilirrubina/metabolismo , Bilirrubina/sangue , Metabolômica/métodos , Multiômica
6.
Nat Commun ; 15(1): 7550, 2024 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-39214992

RESUMO

Jaundice affects almost all neonates in their first days of life and is caused by the accumulation of bilirubin. Although the core biochemistry of bilirubin metabolism is well understood, it is not clear why some neonates experience more severe jaundice and require treatment with phototherapy. Here, we present the first genome-wide association study of neonatal jaundice to date in nearly 30,000 parent-offspring trios from Norway (cases ≈ 2000). The alternate allele of a common missense variant affecting the sequence of UGT1A4 reduces the susceptibility to jaundice five-fold, which replicated in separate cohorts of neonates of African American and European ancestries. eQTL colocalization analyses indicate that the association may be driven by regulation of UGT1A1 in the intestines, but not in the liver. Our results reveal marked differences in the genetic variants involved in neonatal jaundice compared to those regulating bilirubin levels in adults, suggesting distinct genetic mechanisms for the same biological pathways.


Assuntos
Bilirrubina , Estudo de Associação Genômica Ampla , Glucuronosiltransferase , Icterícia Neonatal , Humanos , Icterícia Neonatal/genética , Icterícia Neonatal/metabolismo , Bilirrubina/metabolismo , Glucuronosiltransferase/genética , Glucuronosiltransferase/metabolismo , Recém-Nascido , Adulto , Feminino , Masculino , Polimorfismo de Nucleotídeo Único , Predisposição Genética para Doença , Noruega , Locos de Características Quantitativas , Alelos , Mutação de Sentido Incorreto , Fígado/metabolismo , População Branca/genética
7.
Turk J Med Sci ; 54(3): 502-507, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39050006

RESUMO

Background/aim: The aim of this study was to investigate the effect of phototherapy treatment on serum melatonin levels in term newborn infants. Material and methods: This study was planned as a single-center, prospective, observational, case-control study. Term infants (gestation week ≥37 weeks) who received at least 6 h of phototherapy due to jaundice constitute the phototherapy group, while the term infants without jaundice and who were exclusively breastfed constitute the control group. Melatonin levels were examined by taking blood samples from babies in both groups at 02:00 at night. Melatonin values were compared between groups. The effect of phototherapy on serum melatonin levels was investigated. The relationship between the duration of phototherapy and maximum serum bilirubin values on melatonin values was investigated. Results: Seventy term infants (64.3% girls) were included in the study. Mean gestational week was 38.3 ± 1.1 weeks, mean birth weight was 3295 ± 434 g. There was no statistically significant difference between the phototherapy group and the control group in terms of sex, type of delivery, gestational week, birth weight, height, and head circumference (all p > 0.05). Serum melatonin level was 20.3 ± 5.9 pg/mL (range: 8.7-36.6 pg/mL) in the phototherapy group and 19.9 ± 4.38 pg/mL (range: 9.9-26.3 pg/mL) in the control group. There was no significant difference between the two groups in terms of serum melatonin levels (p = 0.155). The mean total bilirubin value was 17.65 ± 1.48 mg/dL, and the average duration of phototherapy application was 13.94 ± 7.64 h in the babies in the phototherapy group. No correlation was found between the duration of phototherapy application and serum melatonin levels (p = 0.791). Conclusion: It was determined that there was no significant difference in serum melatonin levels in term newborn babies who received phototherapy for at least 6 h due to jaundice. No correlation was found between the duration of phototherapy application and the serum melatonin level of the maximum bilirubin values.


Assuntos
Bilirrubina , Melatonina , Fototerapia , Humanos , Melatonina/sangue , Recém-Nascido , Fototerapia/métodos , Feminino , Masculino , Estudos de Casos e Controles , Estudos Prospectivos , Bilirrubina/sangue , Icterícia Neonatal/terapia , Icterícia Neonatal/sangue
8.
Adv Skin Wound Care ; 37(7): 1-9, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38899824

RESUMO

OBJECTIVE: To investigate the effects of tub bathing on the skin and bilirubin levels of newborns receiving tunnel and light-emitting diode phototherapy. METHODS: In this randomized controlled trial, hospitalized newborns diagnosed with hyperbilirubinemia treated with a tunnel or light-emitting diode device were randomly assigned to either the experimental (bath) or control (no bath) groups using a computer program. The skin integrity moisture balance of all groups was recorded using the Newborn Skin Condition Score at 6, 12, and 24 hours after phototherapy, and their total serum bilirubin measurements were evaluated. RESULTS: A statistically significant difference was observed in the babies' total serum bilirubin levels; this decrease was the highest in the experimental groups. Further, the skin integrity-moisture balance was higher in the experimental groups than in the control groups; it was highest in the tunnel-experimental group and lowest in the tunnel control group. CONCLUSIONS: These results show that bathing is effective in reducing total bilirubin levels. This study adds to the evidence on skin integrity and moisture balance in newborns who were bathed during phototherapy.


Assuntos
Banhos , Bilirrubina , Fototerapia , Humanos , Recém-Nascido , Fototerapia/métodos , Banhos/métodos , Bilirrubina/sangue , Feminino , Masculino , Hiperbilirrubinemia Neonatal/terapia , Resultado do Tratamento , Icterícia Neonatal/terapia , Icterícia Neonatal/sangue , Pele/efeitos da radiação
9.
Int J Gynaecol Obstet ; 166(1): 115-125, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38831742

RESUMO

OBJECTIVE: To explore the relationships between gestational hepatitis B virus (HBV) infection, antiviral therapy, and pregnancy outcomes. METHODS: We retrospectively selected hepatitis B surface antigen (HBsAg)-positive pregnant women hospitalized for delivery at Fujian Medical University Affiliated Hospital from October 1, 2016 to October 1, 2020. The control group included randomly selected healthy pregnant women hospitalized for delivery during the same time. RESULTS: Overall, 1115 participants were enrolled and grouped into control (n = 380) and HBsAg-positive groups (n = 735), which were further divided into groups I (n = 407; low viral load), II (n = 207; high viral load without antiviral therapy), and III (n = 121; high viral load with antiviral therapy). Pregnant women with HBV were positively correlated with the incidence of intrahepatic cholestasis of pregnancy (ICP) (adjusted odds ratio [aOR] 5.1, 95% confidence interval [CI] 2.62-9.92, P < 0.001), neonatal jaundice (aOR 10.56, 95% CI 4.49-24.83, P < 0.001), and neonatal asphyxia (aOR 5.03, 95% CI 1.46-17.27, P = 0.01). Aspartate aminotransferase (AST) greater than the upper limit of normal (ULN) was an independent risk factor for increased ICP incidence (aOR 3.49, 95% CI 1.26-9.67, P = 0.019). Antiviral therapy considerably reduced HBV DNA and improved liver function. High viral load and antiviral therapy did not correlate significantly with adverse pregnancy outcomes (P < 0.05). CONCLUSION: Pregnant women with HBV have significantly elevated incidence of ICP, neonatal jaundice, and neonatal asphyxia not significantly correlated with viral load. AST greater than ULN independently increases the risk of ICP. Antiviral therapy effectively reduces viral replication and improves liver function without increasing the risk of adverse outcomes.


Assuntos
Antivirais , Hepatite B , Complicações Infecciosas na Gravidez , Resultado da Gravidez , Carga Viral , Humanos , Feminino , Gravidez , Estudos Retrospectivos , Antivirais/uso terapêutico , Complicações Infecciosas na Gravidez/tratamento farmacológico , Complicações Infecciosas na Gravidez/virologia , Adulto , Hepatite B/epidemiologia , Hepatite B/tratamento farmacológico , Colestase Intra-Hepática/epidemiologia , China/epidemiologia , Antígenos de Superfície da Hepatite B/sangue , Vírus da Hepatite B , Recém-Nascido , Estudos de Casos e Controles , Icterícia Neonatal/epidemiologia , Complicações na Gravidez
10.
BMJ Open ; 14(6): e083641, 2024 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-38851232

RESUMO

INTRODUCTION: Neonatal jaundice is a common and life-threatening health problem in neonates due to overaccumulation of circulating unconjugated bilirubin. Gut flora has a potential influence on bilirubin metabolism. The infant gut microbiome is commonly copied from the maternal gut. During pregnancy, due to changes in dietary habits, hormones and body weight, maternal gut dysbiosis is common, which can be stabilised by probiotics supplementation. However, whether probiotic supplements can reach the baby through the mother and reduce the incidence of neonatal jaundice has not been studied yet. Therefore, we aim to evaluate the effect of prenatal maternal probiotic supplementation on the incidence of neonatal jaundice. METHODS AND ANALYSIS: This is a randomised double-blind placebo-controlled clinical trial among 94 pregnant women (47 in each group) in a tertiary hospital in Hong Kong. Voluntary eligible participants will be recruited between 28 and 35 weeks of gestation. Computer-generated randomisation and allocation to either the intervention or control group will be carried out. Participants will take either one sachet of Vivomixx (450 billion colony-forming units per sachet) or a placebo per day until 1 week post partum. Neither the study participants nor researchers will know the randomisation and allocation. The intervention will be initiated at 36 weeks of gestation. Neonatal bilirubin level will be measured to determine the primary outcome (hyperbilirubinaemia) while the metagenomic microbiome profile of breast milk and maternal and infant stool samples as well as pregnancy outcomes will be secondary outcomes. Binary logistic and linear regressions will be carried out to assess the association of the microbiome data with different clinical outcomes. ETHICS AND DISSEMINATION: Ethics approval is obtained from the Joint CUHK-NTEC Clinical Research Ethics Committee, Hong Kong (CREC Ref: 2023.100-T). Findings will be published in peer-reviewed journals and presented at international conferences. TRIAL REGISTRATION NUMBER: NCT06087874.


Assuntos
Icterícia Neonatal , Probióticos , Humanos , Probióticos/administração & dosagem , Probióticos/uso terapêutico , Feminino , Método Duplo-Cego , Gravidez , Icterícia Neonatal/prevenção & controle , Recém-Nascido , Hong Kong , Microbioma Gastrointestinal/efeitos dos fármacos , Suplementos Nutricionais , Bilirrubina/sangue , Ensaios Clínicos Controlados Aleatórios como Assunto , Adulto , Cuidado Pré-Natal/métodos
11.
BJOG ; 131 Suppl 3: 113-124, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38853758

RESUMO

OBJECTIVE: To determine the incidence, risk factors and outcomes of babies with neonatal jaundice in a network of referral-level hospitals in Nigeria. DESIGN: A cross-sectional analysis of perinatal data collected over a 1-year period. SETTING: Fifty-four referral-level hospitals (48 public and 6 private) across the six geopolitical zones of Nigeria. POPULATION: A total of 77 026 babies born at or admitted to the participating facilities (67 697 hospital live births; plus 9329 out-born babies), with information on jaundice between 1 September 2019 and 31 August 2020. METHODS: Data were extracted and analysed to calculate incidence and sociodemographic and clinical risk factors for neonatal jaundice. MAIN OUTCOME MEASURES: Incidence and risk factors of neonatal jaundice in the 54-referral hospitals in Nigeria. RESULTS: Of 77 026 babies born in or admitted to the participating facilities, 3228 had jaundice (41.92 per 1000 live births). Of the 67 697 hospital live births, 845 babies had jaundice (12.48 per 1000 live births). The risk factors associated with neonatal jaundice were no formal education (adjusted odds ratio [aOR] 1.68, 95% CI 1.11-2.52) or post-secondary education (aOR 1.17, 95% CI 0.99-1.38), previous caesarean section (aOR 1.68, 95% CI 1.40-2.03), booked antenatal care at <13 weeks or 13-26 weeks of gestation (aOR 1.58, 95% CI 1.20-2.08; aOR 1.15, 95% CI 0.93-1.42, respectively), preterm birth (aOR 1.43, 95% CI 1.14-1.78) and labour more than 18 hours (aOR 2.14, 95% CI 1.74-2.63). CONCLUSIONS: Hospital-level and regional-level strategies are needed to address newborn jaundice, which include a focus on management and discharge counselling on signs of jaundice.


Assuntos
Icterícia Neonatal , Encaminhamento e Consulta , Humanos , Icterícia Neonatal/epidemiologia , Nigéria/epidemiologia , Recém-Nascido , Fatores de Risco , Feminino , Estudos Transversais , Incidência , Gravidez , Encaminhamento e Consulta/estatística & dados numéricos , Masculino , Adulto
12.
J. nurs. health ; 14(2): 1425255, jun. 2024.
Artigo em Português | LILACS, BDENF - Enfermagem | ID: biblio-1560707

RESUMO

Objetivo:identificar os saberes de enfermeiras sobre icterícia neonatal. Método:pesquisa-ação, qualitativa, realizada em uma maternidade pública no Paraná. Nove enfermeiras participaram na etapa de diagnóstico, foram realizadas entrevistas semiestruturadas e análise de conteúdo. Nas etapas de ação e avaliação, participaram 49 profissionais, ocorreu observação participante, entrevista em grupo e análise de conteúdo. Resultados: emergiram três categorias: saberes de enfermeiras para identificação da icterícia neonatal; saberes para manejo adequado; saberes sobre as consequências da icterícia não tratada. Foi identificado pouco conhecimento sobre a fisiopatologia da doença, cuidados específicos e consequências da icterícia inadequadamente tratada. Foi desenvolvida uma capacitação sobre o tema em conjunto com a instituição. Conclusões: na primeira etapa, as enfermeiras demonstraram saber avaliar e identificar precocemente a icterícia, mas tinham pouco conhecimento sobre cuidados com a fototerapia e consequências do tratamento inadequado. São necessárias ações de educação permanente para qualificar a assistência aos recém-nascidos com icterícia


Objective: to identify the knowledge of nurses about neonatal jaundice. Method: qualitative action research conducted in a public maternity hospital in Paraná. Nine nurses participated in the diagnostic stage, semi-structured interviews and content analysis were performed. In the action and evaluation stages, 49 professionals participated, and participant observation, group interviews, and content analysis were conducted. Results: three categories emerged: knowledge of nurses for the identification of neonatal jaundice; knowledge for proper management; knowledge about the consequences of untreated jaundice. Limited knowledge was identified regarding the pathophysiology of the disease, specific care, and consequences of inadequately treated jaundice. Training on the subject was developed in collaboration with the institution. Conclusions: in the first stage, nurses demonstrated the ability to evaluate and identify jaundice early, but had limited knowledge about care with phototherapy and the consequences of inadequate treatment. Continuous education actions are necessary to improve the care for newborns with jaundice.


Objetivo: identificar los conocimientos de las enfermeras sobre la ictericia neonatal. Método: investigación-acción cualitativa, en una maternidad pública en Paraná. Participaron nueve enfermeras en el diagnóstico, mediante entrevistas semiestructuradas y análisis de contenido. En las etapas de acción y evaluación, participaron 49 profesionales, con observación participante, entrevistas grupales y análisis de contenido. Resultados: surgieron tres categorías: conocimientos sobre la identificación, manejo adecuado y consecuencias de la ictericia neonatal no tratada. Se identificó poco conocimiento sobre la fisiopatología, cuidados específicos y consecuencias de la ictericia no tratada adecuadamente. Se desarrolló una capacitación en conjunto con la institución. Conclusiones: en la primera etapa, las enfermeras demostraron saber evaluar e identificar precozmente la ictericia,pero tenían poco conocimiento sobre los cuidados con la fototerapia y las consecuencias del tratamiento inadecuado. Se necesitan acciones de educación continua para mejorar la atención a los recién nacidos con ictericia


Assuntos
Enfermagem Neonatal , Enfermagem Pediátrica , Saúde da Criança , Icterícia Neonatal , Enfermeiras e Enfermeiros
13.
Eur J Pediatr ; 183(8): 3389-3396, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38767694

RESUMO

Phototherapy (PT) is a widely used treatment for neonatal jaundice, yet the ideal model of application remains controversial. In this study, the effects of continuous phototherapy (CPT) and intermittent phototherapy (IPT) models were compared in the treatment of neonatal indirect hyperbilirubinemia (IHB) and whether IPT is a superior modality is investigated. Single-centre parallel randomized controlled open label trial. A computer-based table of random numbers was used to allocate treatments. Newborns ≥ 34 weeks' gestation who received phototherapy in our neonatal intensive care unit (NICU) between July 2022 and April 2023 were included. CPT was applied continuously for 6 h, and IPT was applied as 2 cycles of 1 h on and 2 h off in a 6-h session. Rebound TSB was measured 8 h after phototherapy was stopped in both groups. Phototherapy duration, TSB reduction rate and rebound bilirubin rate were compared between intervention groups. One hundered and four neonates met the inclusion criteria during the study period. CPT and IPT were each used in 52 newborns. Demographic characteristics of the study groups, including sex, mode of delivery, birth weight, admission weight, age at postnatal presentation, diet, discharge weight, and history of PT in siblings, were similar (p > 0.05). The most common cause of IHB in both groups was ABO incompatibility. The median phototherapy time was 12 h (6-15) in the CPT group and 4 h (2-4) in the IPT group (p < 0.001). The mean rate of bilirubin decrease was 1.12 ± 0.73 mg/dl/h in those who underwent IPT and 0.51 ± 0.33 mg/dl/h in those who underwent CPT (p < 0.001). The mean rebound bilirubin rate 8 h after phototherapy was 0.08 ± 0.28 mg/dl/h in the CPT group, and -0.01 ± 0.17 mg/dl/h in the IPT group (p = 0.039). The length of hospital stay was longer in the CPT group (p = 0.032). Skin rash, diarrhoea and increased body temperature were less frequent in the IPT group (p < 0.001). CONCLUSIONS: In this study, IPT was found to be at least as effective as CPT in reducing total serum bilirubin. Even though the duration of PT is shorter in IPT, the slower rate of rebound bilirubin, shorter hospital stays and lower incidence of side effects indicated that intermittent phototherapy is superior to continuous phototherapy. Choosing IPT over CPT is a more rational approach in neonatal jaundice. CLINICALTRIALS: gov Identifier: NCT06386731 (registered retrospectively on 23/04/2024) What is Known: • PT is common used in the treatment of neonatal jaundice. • There is no standard model of application for PT. WHAT IS NEW: • The IPT model is as effective as CPT. • Newborns are discharged faster with IPT.


Assuntos
Icterícia Neonatal , Fototerapia , Humanos , Recém-Nascido , Fototerapia/métodos , Icterícia Neonatal/terapia , Feminino , Masculino , Resultado do Tratamento , Unidades de Terapia Intensiva Neonatal , Bilirrubina/sangue
14.
J Neonatal Perinatal Med ; 17(2): 161-167, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38759028

RESUMO

OBJECTIVES: Hypernatremia may facilitate the diffusion of bilirubin through the blood-brain barrier and increase the risk of bilirubin encephalopathy. This study was conducted to compare the prognosis of jaundice infants with those with jaundice and hypernatremia. METHODS: A total of 615 term infants with idiopathic jaundice with or without hypernatremia were enrolled in this cohort study with 24-months follow-up at Ghaem Hospital, Mashhad, Iran, between 2010 and 2022. An in-house questionnaire including the laboratory evaluation and neonatal characteristics was used as the data collection tool. The follow-up of neonatal development status was performed using the Denver test II at 6, 12, 18, and 24 months after discharging from hospital. RESULTS: Normal outcomes were seen in 555 (90.2%) out of 615 studied infants, while 60 cases (9.8%) showed abnormal outcomes. Serum levels of sodium (P = 0.017), bilirubin (P = 0.001), urea (P = 0.024), and creatinine (P = 0.011) as well as hyperthermia (P = 0.046) and unconsciousness (P = 0.005) showed significant differences between the two groups. Approximately 16% of the newborns with both jaundice and hypernatremia, and 9% of those with only jaundice had unfavorable prognoses. Also, bilirubin level had the most predictive power (91.3%). CONCLUSIONS: Our results suggest that hypernatremia or jaundice alone, may affect the prognosis of infants aged 2 years; but jaundice and hypernatremia together, will intensify the developmental problems in jaundice infants. However, the role of hyperbilirubinemia in the incidence of complications is more than hypernatremia.


Assuntos
Bilirrubina , Hipernatremia , Humanos , Hipernatremia/sangue , Hipernatremia/epidemiologia , Hipernatremia/diagnóstico , Feminino , Recém-Nascido , Masculino , Prognóstico , Bilirrubina/sangue , Irã (Geográfico)/epidemiologia , Lactente , Icterícia Neonatal/sangue , Icterícia Neonatal/epidemiologia , Hiperbilirrubinemia Neonatal/complicações , Hiperbilirrubinemia Neonatal/sangue , Hiperbilirrubinemia Neonatal/epidemiologia , Kernicterus/epidemiologia , Kernicterus/sangue , Kernicterus/etiologia , Seguimentos , Estudos de Coortes
15.
BMC Health Serv Res ; 24(1): 671, 2024 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-38807158

RESUMO

BACKGROUND: Neonatal jaundice is a common condition that can lead to brain damage and disabilities when severe cases go undetected. Low- and middle-income countries often lack accurate methods for detecting neonatal jaundice and rely on visual assessment, resulting in a higher incidence of adverse consequences. Picterus Jaundice Pro (Picterus JP), an easy-to-use and affordable smartphone-based screening device for the condition, has demonstrated higher accuracy than visual assessment in Norwegian, Philippine and Mexican newborns. This study aimed to identify the barriers and facilitators to implementing Picterus JP in public health services in low-income settings in Mexico by exploring the current process of neonatal jaundice detection and stakeholders' perspectives in that context. METHODS: Qualitative data collection techniques, including one focus group, 15 semi-structured interviews and four observations, were employed in urban and rural health facilities in Oaxaca, Mexico. The participants included medical doctors, nurses and health administrators. The data were analysed by thematic analysis guided by the Consolidated Framework for Implementation Research. RESULTS: The analysis yielded four main themes: (I) the current state of neonatal care and NNJ detection, (II) the needs and desires for enhancing NNJ detection, (III) the barriers and facilitators to implementing Picterus JP in the health system and (IV) HCWs' expectations of Picterus JP. The findings identify deficiencies in the current neonatal jaundice detection process and the participants' desire for a more accurate method. Picterus JP was perceived as easy to use, useful and compatible with the work routine, but barriers to adoption were identified, including internet deficiencies and costs. CONCLUSIONS: The introduction of Picterus JP as a supporting tool to screen for neonatal jaundice is promising but contextual barriers in the setting must be addressed for successful implementation. There is also an opportunity to optimise visual assessment to improve detection of neonatal jaundice.


Assuntos
Grupos Focais , Icterícia Neonatal , Pesquisa Qualitativa , Telemedicina , Humanos , Icterícia Neonatal/diagnóstico , Recém-Nascido , México , Triagem Neonatal/métodos , Feminino , Masculino , Países em Desenvolvimento , Entrevistas como Assunto , Smartphone
16.
Biosensors (Basel) ; 14(5)2024 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-38785728

RESUMO

One of the most common problems many babies encounter is neonatal jaundice. The symptoms are yellowing of the skin or eyes because of bilirubin (from above 2.0 to 2.5 mg/dL in the blood). If left untreated, it can lead to serious neurological complications. Traditionally, jaundice detection has relied on invasive blood tests, but developing non-invasive biosensors has provided an alternative approach. This systematic review aims to assess the advancement of these biosensors. This review discusses the many known invasive and non-invasive diagnostic modalities for detecting neonatal jaundice and their limitations. It also notes that the recent research and development on non-invasive biosensors for neonatal jaundice diagnosis is still in its early stages, with the majority of investigations being in vitro or at the pre-clinical level. Non-invasive biosensors could revolutionize neonatal jaundice detection; however, a number of issues still need to be solved before this can happen. These consist of in-depth validation studies, affordable and user-friendly gadgets, and regulatory authority approval. To create biosensors that meet regulatory requirements, additional research is required to make them more precise and affordable.


Assuntos
Técnicas Biossensoriais , Icterícia Neonatal , Humanos , Icterícia Neonatal/diagnóstico , Recém-Nascido , Bilirrubina/análise
17.
Cochrane Database Syst Rev ; 5: CD011060, 2024 05 28.
Artigo em Inglês | MEDLINE | ID: mdl-38804265

RESUMO

BACKGROUND: The American Academy of Pediatrics and the Canadian Paediatric Society both advise that all newborns should undergo bilirubin screening before leaving the hospital, and this has become the standard practice in both countries. However, the US Preventive Task Force has found no strong evidence to suggest that this practice of universal screening for bilirubin reduces the occurrence of significant outcomes such as bilirubin-induced neurologic dysfunction or kernicterus. OBJECTIVES: To evaluate the effectiveness of transcutaneous screening compared to visual inspection for hyperbilirubinemia to prevent the readmission of newborns (infants greater than 35 weeks' gestation) for phototherapy. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, CINAHL, ClinicalTrials.gov, ICTRP, and ISRCTN in June 2023. We also searched conference proceedings, and the reference lists of included studies. SELECTION CRITERIA: We included randomized controlled trials (RCTs), quasi-randomized, cluster-randomized, or prospective cohort studies with control arm that evaluated the use of transcutaneous bilirubin (TcB) screening for hyperbilirubinemia in newborns before hospital discharge. DATA COLLECTION AND ANALYSIS: We used standard methodologic procedures expected by Cochrane. We evaluated treatment effects using a fixed-effect model with risk ratio (RR) and 95% confidence intervals (CI) for categorical data and mean, standard deviation (SD), and mean difference (MD) for continuous data. We used the GRADE approach to evaluate the certainty of evidence. MAIN RESULTS: We identified one RCT that met our inclusion criteria. The study included 1858 African newborns at 35 weeks' gestation or greater who were receiving routine care at a well-baby nursery, and were randomly recruited prior to discharge to undergo TcB screening. The study had good methodologic quality. TcB screening versus visual assessment of hyperbilirubinemia in newborns: - probably reduces readmission to the hospital for hyperbilirubinemia (RR 0.25, 95% CI 0.14 to 0.46; P < 0.0001; moderate-certainty evidence); - may have little or no effect on the rate of exchange transfusion (RR 0.20, 95% CI 0.01 to 14.16; low-certainty evidence); - probably increases the number of newborns who require phototherapy prior to discharge (RR 2.67, 95% CI 1.56 to 4.55; moderate-certainty evidence). - may have little or no effect on the rate of acute bilirubin encephalopathy (RR 0.33, 95% CI 0.01 to 8.18; low-certainty evidence). The study did not evaluate or report cost of care. AUTHORS' CONCLUSIONS: Moderate-certainty evidence suggests that TcB screening probably reduces hospital readmission for hyperbilirubinemia compared to visual inspection. Low-certainty evidence also suggests that TcB screening may have little or no effect on the rate of exchange transfusion compared to visual inspection. However, moderate-certainty evidence suggests that TcB screening probably increases the number of newborns that require phototherapy before discharge compared to visual inspection. Low-certainty evidence suggests that TcB screening may have little or no effect on the rate of acute bilirubin encephalopathy compared to visual inspection. Given that we have only identified one RCT, further studies are necessary to determine whether TcB screening can help to reduce readmission and complications related to neonatal hyperbilirubinemia. In settings with limited newborn follow-up after hospital discharge, identifying newborns at risk of severe hyperbilirubinemia before hospital discharge will be important to plan targeted follow-up of these infants.


Assuntos
Bilirrubina , Recém-Nascido Prematuro , Icterícia Neonatal , Triagem Neonatal , Readmissão do Paciente , Ensaios Clínicos Controlados Aleatórios como Assunto , Humanos , Recém-Nascido , Bilirrubina/sangue , Icterícia Neonatal/diagnóstico , Icterícia Neonatal/terapia , Icterícia Neonatal/sangue , Triagem Neonatal/métodos , Readmissão do Paciente/estatística & dados numéricos , Viés , Hiperbilirrubinemia Neonatal/diagnóstico , Hiperbilirrubinemia Neonatal/terapia , Fototerapia , Nascimento a Termo
18.
Zhonghua Er Ke Za Zhi ; 62(6): 535-541, 2024 Jun 02.
Artigo em Chinês | MEDLINE | ID: mdl-38763875

RESUMO

Objective: To evaluate the diagnostic efficacy and practicality of the Jaundice color card (JCard) as a screening tool for neonatal jaundice. Methods: Following the standards for reporting of diagnostic accuracy studies (STARD) statement, a multicenter prospective study was conducted in 9 hospitals in China from October 2019 to September 2021. A total of 845 newborns who were admitted to the hospital or outpatient department for liver function testing due to their own diseases. The inclusion criteria were a gestational age of ≥35 weeks, a birth weight of ≥2 000 g, and an age of ≤28 days. The neonate's parents used the JCard to measure jaundice at the neonate's cheek. Within 2 hours of the JCard measurement, transcutaneous bilirubin (TcB) was measured with a JH20-1B device and total serum bilirubin (TSB) was detected. The Pearson's correlation analysis, Bland-Altman plots and the receiver operating characteristic (ROC) curve were used for statistic analysis. Results: Out of the 854 newborns, 445 were male and 409 were female; 46 were born at 35-36 weeks of gestational age and 808 were born at ≥37 weeks of gestational age. Additionally, 432 cases were aged 0-3 days, 236 cases were aged 4-7 days, and 186 cases were aged 8-28 days. The TSB level was (227.4±89.6) µmol/L, with a range of 23.7-717.0 µmol/L. The JCard level was (221.4±77.0) µmol/L and the TcB level was (252.5±76.0) µmol/L. Both the JCard and TcB values showed good correlation (r=0.77 and 0.80, respectively) and agreements (96.0% (820/854) and 95.2% (813/854) of samples fell within the 95% limits of agreement, respectively) with TSB. The JCard value of 12 had a sensitivity of 0.93 and specificity of 0.75 for identifying a TSB ≥205.2 µmol/L, and a sensitivity of 1.00 and specificity of 0.35 for identifying a TSB ≥342.0 µmol/L. The TcB value of 205.2 µmol/L had a sensitivity of 0.97 and specificity of 0.60 for identifying TSB levels of 205.2 µmol/L, and a sensitivity of 1.00 and specificity of 0.26 for identifying TSB levels of 342.0 µmol/L. The areas under the ROC curve (AUC) of JCard for identifying TSB levels of 153.9, 205.2, 256.5, and 342.0 µmol/L were 0.96, 0.92, 0.83, and 0.83, respectively. The AUC of TcB were 0.94, 0.91, 0.86, and 0.87, respectively. There were both no significant differences between the AUC of JCard and TcB in identifying TSB levels of 153.9 and 205.2 µmol/L (both P>0.05). However, the AUC of JCard were both lower than those of TcB in identifying TSB levels of 256.5 and 342.0 µmol/L (both P<0.05). Conclusions: JCard can be used to classify different levels of bilirubin, but its diagnostic efficacy decreases with increasing bilirubin levels. When TSB level are ≤205.2 µmol/L, its diagnostic efficacy is equivalent to that of the JH20-1B. To prevent the misdiagnosis of severe jaundice, it is recommended that parents use a low JCard score, such as 12, to identify severe hyperbilirubinemia (TSB ≥342.0 µmol/L).


Assuntos
Bilirrubina , Hiperbilirrubinemia Neonatal , Icterícia Neonatal , Sensibilidade e Especificidade , Humanos , Recém-Nascido , Bilirrubina/sangue , Estudos Prospectivos , Feminino , Masculino , Hiperbilirrubinemia Neonatal/diagnóstico , Hiperbilirrubinemia Neonatal/sangue , Icterícia Neonatal/diagnóstico , Icterícia Neonatal/sangue , Curva ROC , Triagem Neonatal/métodos , Idade Gestacional , Pais
19.
Eur J Pediatr ; 183(7): 2819-2830, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38581462

RESUMO

Measurement of transcutaneous bilirubin (TcB) is a non-invasive, widely used technique to estimate serum bilirubin (SB). However, its reliability in multiethnic populations during and after phototherapy is still controversial even in covered skin. The aim of this study was to determine the reliability of TcB in covered (cTcB) and exposed (eTcB) skin during and after phototherapy in a multiethnic population of term and preterm neonates according to Neomar's neonatal skin color scale. Prospective, observational study comparing SB and TcB. We determined SB when clinically indicated and, at the same time, measured cTcB under a photo-opaque patch and eTcB next to it with a jaundice meter (Dräger JM-105TM). All dyads TcB-SB were compared, both globally and according to skin color. We obtained data from 200 newborns (color1: 44, color2: 111, color3: 41, color4: 4) and compared 296 dyads TcB/SB. Correlation between cTcB and SB is strong during (0.74-0.83) and after (0.79-0.88) phototherapy, both globally and by color group. The SB-cTcB bias depends on gestational age during phototherapy and on skin color following phototherapy. The correlation between eTcB and SB during phototherapy is not strong (0.54), but becomes so 12 h after discontinuing phototherapy (0.78).  Conclusions: Our study supports the reliability of cTcB to assess SB during and after phototherapy, with differences among skin tones after the treatment. The use of cTcB and Neomar's scale during and mainly after phototherapy may help reduce the number of blood samples required. What is Known: • Controversies exist on the reliability of jaundice meters during and after phototherapy in covered skin. Only a few studies have analyzed their accuracy in multiethnic populations, but none has used a validated neonatal skin color scale. What is New: • We verified correlation between serum and transcutaneous bilirubin in covered skin in a multiethnic population depending on skin color based on our own validated neonatal skin color scale during and after phototherapy.


Assuntos
Bilirrubina , Icterícia Neonatal , Fototerapia , Pigmentação da Pele , Humanos , Bilirrubina/sangue , Bilirrubina/análise , Recém-Nascido , Estudos Prospectivos , Reprodutibilidade dos Testes , Feminino , Fototerapia/métodos , Icterícia Neonatal/terapia , Icterícia Neonatal/sangue , Icterícia Neonatal/diagnóstico , Masculino , Triagem Neonatal/métodos , Recém-Nascido Prematuro , Idade Gestacional
20.
Sci Rep ; 14(1): 9520, 2024 04 25.
Artigo em Inglês | MEDLINE | ID: mdl-38664452

RESUMO

The link between neonatal jaundice and urinary tract infection (UTI) remains debated, with congenital kidney and urinary tract anomalies (CAKUT) potentially playing a role. This population-based study aimed to analyze the correlations between neonatal jaundice, CAKUT, and concomitant UTI. The study cohort consisted of 2,078,122 live births from 2004 to 2014. We linked several population-based datasets in Taiwan to identify infants with unexplained neonatal jaundice and their mothers. The primary outcome was the rate of CAKUT occurring within 3 years after delivery, and the presence of concomitant UTI during neonatal jaundice hospitalization. Infants with neonatal jaundice had a significantly higher risk of CAKUT (adjusted odds ratio [aOR] 1.24, 95% confidence interval [CI] 1.11-1.39) during early childhood. Among the subtypes of CAKUT, obstructive uropathy, vesicoureteral reflux and other CAKUT were associated with an increased risk of neonatal jaundice. Infants who underwent intensive phototherapy, had a late diagnosis (> 14 days of postnatal age) or underwent a prolonged duration of phototherapy (> 3 days) exhibited a higher risk of concomitant UTI compared to other infants with jaundice. Our findings indicate a notable association between neonatal jaundice and increased risks of UTIs in the context of CAKUT. This study underscore the importance of vigilant monitoring and timely interventions for neonates presenting with jaundice, while acknowledging the complexity and variability in the progression of CAKUT and its potential connection to UTIs.


Assuntos
Icterícia Neonatal , Infecções Urinárias , Refluxo Vesicoureteral , Humanos , Infecções Urinárias/complicações , Infecções Urinárias/epidemiologia , Icterícia Neonatal/epidemiologia , Icterícia Neonatal/complicações , Icterícia Neonatal/etiologia , Feminino , Recém-Nascido , Masculino , Taiwan/epidemiologia , Fatores de Risco , Rim/anormalidades , Lactente , Sistema Urinário/anormalidades , Anormalidades Urogenitais/complicações , Anormalidades Urogenitais/epidemiologia
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