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1.
Bioorg Chem ; 131: 106324, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36563414

RESUMO

Chemical investigation of an alcohol extract from the twigs and leaves of Illicium henryi Diels resulted in the isolation of two new acorane-related seco-sesquiterpenes (1 and 3), two new acorane-related seco-norsesquiterpenes (2 and 4), one new 2-epi-cedrane sesquiterpene (5), eight new acorane-type sesquiterpenes (6-13), and a known major constituent of acorenone B (14). Their structures were established by interpreting extensive spectroscopic data, including HRESIMS, NMR (1H and 13C NMR, 1H-1H COSY, HSQC, and HMBC), and NOE difference spectra analysis. The absolute configurations of 1, 2, 4-7, 9, 10, and 14 were determined by X-ray crystallography, while chemical transformation methods were performed with compound 14 as the starting material to elegantly solve the absolute configuration issue of compounds 8 and 11-13. Notably, 1 and 2 are seco-sesquiterpenes that are related to acorane and possess an unusual ketal-linked hemiacetal in a 6,8-dioxabicyclo[3.2.1]octan-7-ol scaffold ring system. Plausible biosynthetic pathways for compounds 1-14, which were derived from the acorane skeleton, were proposed. All the isolated compounds (1-14) were evaluated for their antiviral and cytotoxic activities.


Assuntos
Illicium , Sesquiterpenos , Estrutura Molecular , Illicium/química , Antivirais/química , Espectroscopia de Ressonância Magnética , Sesquiterpenos/química , Folhas de Planta
2.
Fish Shellfish Immunol ; 127: 455-462, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35777711

RESUMO

Our present study investigates the effects of Illicium verum enriched diet on growth performance, immune response and disease resistance in Catla catla fingerlings against Aeromonas hydrophila. Experimental groups, i.e., infected C. catla were fed with 5 g/kg, 10 g/kg and 15 g/kg of I. verum diet for a period of 30 days showed a significant increase in their final body weight (FBW) over control. There was a significant increase (p < 0.05) in total weight gain (TWG), specific growth rate (SGR), feed conversion rate (FCR), protein efficiency ratio (PER), condition factor (CF) and survival rate (SR) in 10 g/kg and 15 g/kg groups compared to control; also from 31 to 60 days these groups showed an enhanced (p < 0.05) complement activity, phagocytic activity, respiratory burst activity and lysosome activity. The experimental group fed with 10 g/kg of I. verum diet showed the least cumulative mortality rate (5%) compared to 5 g/kg (30%) and 15 g/kg (15%) experimental groups and in control (10%) and negative control (75%). Our present study highlights that challenged fish fed with the mid dosage of 10 g/kg showed a significant increase in overall growth performance, non susceptibility to diseases and tolerance against A. hydrophila in C. catla compared to other experimental groups including the group given with high dosage of 15 g/kg. Thus our results suggest 10 g/kg as the optimal dosage of I. verum that can be used to enrich the fish diet for a better performance and effective immunostimulation in commercially important C. catla for its sustainable culture and is reported for the first time.


Assuntos
Cyprinidae , Doenças dos Peixes , Infecções por Bactérias Gram-Negativas , Illicium , Aeromonas hydrophila/fisiologia , Ração Animal/análise , Animais , China , Dieta/veterinária , Suplementos Nutricionais , Resistência à Doença , Infecções por Bactérias Gram-Negativas/veterinária
3.
Phytochemistry ; 202: 113323, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-35835233

RESUMO

One undescribed diterpenoid illisimonone A, four undescribed sesquiterpenes named (±)-simonones A, simonterpenoids A and B, and two undescribed lignans, illisimonins A and B, along with five known compounds were isolated from the fruits of Illicium simonsii. Their structures were elucidated by extensive spectroscopic data. The absolute configuration of illisimonone A was determined by single-crystal X-ray diffraction analysis. Illisimonone A showed potential antiviral activity against the Coxsackie B3 virus, with an IC50 value of 3.70 µM. Illisimonin B and henrylactone A showed potential neuroprotective effects against oxygen-glucose deprivation induced cell injury in SK-N-SH cells, with survival rates of 57.6%, 58.0%, respectively.


Assuntos
Illicium , Fármacos Neuroprotetores , Sesquiterpenos , Antivirais/química , Frutas/química , Illicium/química , Estrutura Molecular , Fármacos Neuroprotetores/química , Fármacos Neuroprotetores/farmacologia , Sesquiterpenos/química
4.
Food Res Int ; 157: 111425, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-35761670

RESUMO

The mechanism of star anise dietary fiber (SADF) in improving the water-holding capacity (WHC) of meat batter during chilled storage was investigated. In the 0-day storage group, the cooking loss (CL) decreased from 11.93% to 9.38% with the increased content of SADF, indicating that the physical filling of SADF could improve the WHC of cooked meat batter. After 7 days of chilled storage, the CL of meat batter without SADF increased from 11.93% to 17.65%, while the addition of SADF significantly reduced the CL, especially 2% SADF showing the lowest CL. Additionally, adding SADF could significantly improve the color stability and increase the hardness of cooked meat batter. According to the results of TBARS and carbonyls, SADF significantly inhibited lipid oxidation and alleviated oxidative damage of protein, resulting in an increase in the level of ß-sheet, which was confirmed by the result of FT-IR. Therefore, the water mobility of meat batter was restricted, which was confirmed by the T2 relaxation time. In general, the water retention of meat batter during chilled storage was improved via antioxidant and physical filling of SADF.


Assuntos
Illicium , Água , Fibras na Dieta , Géis , Carne/análise , Espectroscopia de Infravermelho com Transformada de Fourier
5.
Chem Biodivers ; 19(7): e202200429, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35638146

RESUMO

Four highly oxygenated sesquiterpenoids, illimicranolides A (1) and B (2), and illicinolides E (3) and F (4), were obtained from the fruits of Illicium micranthum Dunn, as well as one known analog, illicinolide B (5). The chemical structures of 1-4 were determined comprehensively by 1D (1 H and 13 C) and 2D (HMBC, HSQC, 1 H-1 H COSY, and ROESY) NMR, and HR-ESI-MS data. Structurally, compound 1 was an unprecedented sesquiterpenoid with a 5/5/6/5-fused tetracyclic ring system and was the first seco-prezizaane sesquiterpenoid featuring a 11,8-γ-lactone ring. Compounds 3 and 4 were the fifth and sixth examples of illicinolide-type sesquiterpenoids. Moreover, compound 1 demonstrated neurotrophic activity of NGF-induced PC12 cells with differentiation rate of 10.34 % at a concentration of 10 µM.


Assuntos
Illicium , Sesquiterpenos , Animais , Frutas , Illicium/química , Lactonas/química , Estrutura Molecular , Ratos , Sesquiterpenos/química , Sesquiterpenos/farmacologia
6.
Org Lett ; 24(18): 3411-3415, 2022 05 13.
Artigo em Inglês | MEDLINE | ID: mdl-35499304

RESUMO

We report the first total synthesis of (2R)-hydroxynorneomajucin, a norsesquiterpene derived from the Illicium genus. This natural product displays neurotrophic properties. Small molecule neurotrophins have potential as therapeutics in neurodegenerative diseases. Key steps of our synthesis include a Tsuji-Trost reaction, a Pauson-Khand cyclization, and a Nagata hydrocyanation. A simple sequence of reductions and a Mukaiyama hydration introduce the A-ring substituents with the correct configurations. The overall synthesis was completed in 17 steps (longest linear sequence, LLS).


Assuntos
Produtos Biológicos , Illicium , Ciclização , Estereoisomerismo
7.
PLoS One ; 17(4): e0266949, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35413083

RESUMO

Recently, the effects of weed control on crop yield, quality and soil fertility have been increasingly investigated. However, soil microorganism diversity under weed control, especially for aromatic plants, is little studied. Mechanical weeding effects on soil fertility and microbial diversity in star anise plantations remain unknown, limiting improvements in crop quality and yield through weed control. Therefore, mechanical weeding (MW) and no weeding (NW) zones were randomly designed in the same star anise plantation to study the mechanical weeding impacts on soil biological properties and microbial diversity. The phosphatase activity of MW soil was significantly higher than that of NW soil; however, aminopeptidase activity was significantly lower than that under NW. There was no significant difference in ß-glucosidase activity between MW and NW. Moreover, soil microbial biomass C and N in MW soil were significantly higher than those of NW, but soil microbial biomass P was significantly lower than that of NW. Proteobacteria, Acidobacteria, Actinobacteria, Chloroflexi, Planctomycetes, WPS-2, Firmicutes and Verrucomicrobia were the predominant bacterial phyla in MW and NW soils. Specifically, Bacteroidetes was enriched in MW soil, being the unique dominant bacteria. Ascomycota, Basidiomycota, unclassified_k_Fungi, Rozellomycota and Mortierellomycota were the predominant fungi in MW and NW soils. The numbers of dominant bacterial genera (> 1%) were 26 and 23 for NW and MW soils, respectively. Among them, norank_f__norank_o__norank_c__Subgroup_6, 1921-2 and norank_f__norank_o__B12-WMSP1 went undetected in MW soil. Moreover, the numbers of dominant fungi in soils of star anise plantations were 11 and 9 for NW and MW, respectively. Among them, only unclassified_f__Clavicipitaceae and Mortierella went undetected in MW soils. Thus, soil microbial community structures are not significantly altered by mechanical weeding. The above results suggest that soil fertility can be improved and soil heath can be maintained by mechanical weeding in star anise plantations. Moreover, soil-borne diseases maybe easily occurred under NW treatment in star anise plantation.


Assuntos
Ascomicetos , Illicium , Microbiota , Bactérias/genética , Illicium/química , Solo/química , Microbiologia do Solo
8.
BMC Complement Med Ther ; 22(1): 79, 2022 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-35305622

RESUMO

BACKGROUND: Chronic hyperglycemic triggers the non-enzymatic glycation of biomolecules, resulting in the production of advanced glycation endproducts, that lead to several micro- and macrovascular complications. Therefore, the discovery of new, effective, and safe anti-glycation agents is an important need. One of the best choices for the management of diabetes is to use complementary and alternative medicinal therapies. Therefore, the present study was designed to evaluate the anti-glycation activity of ethanolic extract of Illicium verum Hook. f. (Star anise, a frequently used spice and medicinally important herb). METHODS: The anti-glycation activity of ethanolic extract of Illicium verum Hook. f. was determined by using both in-vitro and in-vivo assays. HSA-fructose glycation model was employed to assess the in-vitro inhibition of protein glycation, additionally cross-linked AGEs (formed by incubating lysozyme with fructose) were assessed by SDS polyacrylamide gel electrophoresis. Dual inhibitory mechanisms, i.e., antioxidant and metal chelating activities, were also evaluated by using DPPH, ABTS, and Fe (II)-chelation assays. Acute toxicity of I. verum extract was also performed (by administrating different doses i.e. 2,000, 1,500, 1,000, and 500 mg/kg of body weight). Finally, in-vivo anti-glycation potential was evaluated by 7 weeks of administration of I. verum extract in streptozotocin-induced diabetic rats. RESULTS: In HSA-fructose glycation model, extract of I. verum showed a good inhibitory activity with IC50 value of 0.11±0.001 mg/mL, as compared to the standard inhibitor, rutin (IC50 = 0.02±0.01 mg/mL). Extract of I. verum showed inhibitory activity in DPPH, and ABTS radical scavenging assays with IC50 values of 130±1.0, and 57±2.0 µg/mL, respectively, while it was found to be inactive in the Fe+2-chelation assay. The extract was found to be non-toxic, and reduce the elevated blood glucose, urea, lipid, liver function parameters, and renal AGEs levels in streptozotocin-induced diabetic rats. CONCLUSIONS: These results suggest that I. verum supplementation might help to reduce the burden of AGEs, and may have potential in preventing diabetes-associated complications.


Assuntos
Diabetes Mellitus Experimental , Illicium , Animais , Antioxidantes/farmacologia , Diabetes Mellitus Experimental/tratamento farmacológico , Frutas , Glicosilação , Illicium/química , Ratos
9.
J Agric Food Chem ; 70(12): 3697-3707, 2022 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-35293738

RESUMO

Illicium verum Hook.f. (Chinese star anise), a known Chinese traditional spice, is commonly applied in Chinese cuisine and cooking in Southeast Asia. As a kind of medicinal and edible resource, the fruit of I. verum has attracted great attention for its chemical constituents and physiological activities. In this work, the phytochemical study of the fruits of I. verum led to the isolation and identification of 20 compounds, including 6 new lignans and phenylpropanoids (1-6) and 14 known ones (7-20). Their structures were characterized by extensive analysis of spectroscopic data (IR, UV, high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), one-dimensional (1D) and two-dimensional (1D) NMR), electronic circular dichroism (ECD) calculation, and by comparison with literature data. Meanwhile, all compounds (1-20) were evaluated for their antiviral and antioxidant activities. Especially, compound 7 [(-)-bornyl p-coumarate] showed strong antiviral activities against influenza virus A/Puerto Rico/8/34 H1N1 (PR8) with an IC50 value of 1.74 ± 0.47 µM, which is much better than those of Tamiflu (IC50 = 10.01 ± 0.92 µM) and ribavirin (IC50 = 10.76 ± 1.60 µM). The antiviral activity against PR8 of compound 7 was reported for the first time, which was sufficiently confirmed by cell counting kit 8 (CCK-8), cytopathic effect (CPE) reduction, and immunofluorescence assays. In this study, the discovery of antiviral and antioxidant components from the fruits of I. verum could benefit the further development and utilization of this plant.


Assuntos
Illicium , Vírus da Influenza A Subtipo H1N1 , Antioxidantes/análise , Antioxidantes/farmacologia , Antivirais/farmacologia , China , Frutas/química , Illicium/química
10.
Chin J Nat Med ; 20(2): 139-147, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35279241

RESUMO

Fourteen new geranyl phenyl ethers (1-14) along with three known compounds (15-17) were isolated from Illicium micranthum, and their structures were elucidated by comprehensive spectroscopic methods. Illimicranins A-H (1-8) were characterized as geranyl vanillin ethers, while 9 and 10 were dimethyl acetal derivatives. Illimicranins I and J (11 and 12) were rare geranyl isoeugenol ethers. Illimicranins K and L (13 and 14) represented the first example of geranyl guaiacylacetone ether and geranyl zingerone ether, respectively. Compounds 1, 2 and 15 exhibited anti-HBV (hepatitis B virus) activity against HBsAg (hepatitis B surface antigen) and HBeAg (hepatitis B e antigen) secretion, and HBV DNA replication.


Assuntos
Illicium , Antivirais/química , Antivirais/farmacologia , Antígenos de Superfície da Hepatite B , Antígenos E da Hepatite B , Illicium/química , Éteres Fenílicos
11.
Molecules ; 27(3)2022 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-35163914

RESUMO

Illicium verum Hook f. (star anise) is considered an important species in Traditional Chinese Medicine and is also used in contemporary medicine in East Asian countries. It occurs in natural habitats in southeastern parts of China and Vietnam, and is cultivated in various regions in China. The raw materials-Anisi stellati fructus and Anisi stellati aetheroleum obtained from this species exhibit expectorant and spasmolytic activities. The European Pharmacopoeia (4th edition) indicates that these raw materials have been used in allopathy since 2002. The biological activities of the above-mentioned raw materials are determined by the presence of valuable secondary metabolites such as monoterpenoids, sesquiterpenoids, phenylpropanoids, and flavonoids. Recent pharmacological studies on fruit extracts and the essential oil of this species have confirmed their antibacterial, antifungal, anti-inflammatory, and antioxidant activities and thus their medicinal and cosmetic value. The aim of this review was to examine the progress of phytochemical and pharmacological studies that focused on possible cosmetic applications. In addition to fruit extracts and essential oil, the current consensus on the safety of trans-anethole, which is the main compound of essential oil used in cosmetology, is underlined here.


Assuntos
Derivados de Alilbenzenos , Illicium , Óleos Voláteis , Anisóis/farmacologia , Illicium/química , Óleos Voláteis/química , Óleos Voláteis/farmacologia
12.
Molecules ; 27(3)2022 Feb 08.
Artigo em Inglês | MEDLINE | ID: mdl-35164380

RESUMO

Two undescribed ether derivatives of sesquiterpenes, 1-ethoxycaryolane-1, 9ß-diol (1) and 2-ethoxyclovane-2ß, 9α-diol (3), and one new monoterpene glycoside, p-menthane-1α,2α,8-triol-4-O-ß-D-glucoside (5), were obtained, together with eight known compounds from the stems and leaves of I. simonsii. Their structures were elucidated by spectroscopic methods. Compounds 1-11 were evaluated for their potency against Staphylococcus aureus and clinical methicillin-resistant S. aureus (MRSA). Among them, compound 3 was weakly active against S. aureus (MIC = 128 µg/mL), and compounds 6 and 7 exhibited good antibacterial activity against S. aureus and MRSA (MICs = 2-8 µg/mL). A primary mechanism study revealed that compounds 6 and 7 could kill bacteria by destroying bacterial cell membranes. Moreover, compounds 6 and 7 were not susceptible to drug resistance development.


Assuntos
Antibacterianos/análise , Illicium/química , Monoterpenos/análise , Sesquiterpenos/análise , Antibacterianos/farmacologia , Humanos , Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos , Monoterpenos/farmacologia , Folhas de Planta/química , Caules de Planta/química , Sesquiterpenos/farmacologia , Infecções Estafilocócicas/tratamento farmacológico
13.
Pestic Biochem Physiol ; 181: 105027, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35082043

RESUMO

The aim of this work was to test the insecticidal effect of the essential oil of Illicium verum (Hook) by observing the survival, biochemical parameters (acetylcholinesterase (AChE) activity, glutathione s-transferase (GST) activity and the concentration of reactive oxygen species (ROS)) and locomotor capacity of the Coleoptera Alphitobius diaperinus (Panzer), a pest of beef poultry. The sublethal concentrations (100% survival of A. diaperinus during 96 h of exposure) of I. verum essential oil selected for analysis were 0.5% and 1%. The selected sublethal concentrations did not show significant increases in ROS levels after 24 h of exposure to the essential oil. However, increases in GST activity were seen following exposure to 0.5% I. verum essential oil, while decreases in AChE activity were observed following exposure to concentrations of 0.5% and 1%. These results correlate with the observed behavior of A. diaperinus; when placed into an arena, these insects typically demonstrate aversion to stimuli and refuge-seeking behavior. Following exposure to 0.5% I. verum essential oil, the insects showed loss of refuge-seeking capacity and, following exposure to a concentration of 1%, loss of locomotor capacity. Overall, these results indicate that I. verum essential oil can be used as an alternative to conventional insecticides.


Assuntos
Besouros , Illicium , Inseticidas , Óleos Voláteis , Acetilcolinesterase , Animais , Bovinos , Colinesterases , Inseticidas/farmacologia , Locomoção , Óleos Voláteis/farmacologia
14.
Bioorg Med Chem Lett ; 60: 128580, 2022 03 15.
Artigo em Inglês | MEDLINE | ID: mdl-35066142

RESUMO

Majucin-type Illicium sesquiterpenes with potent neurotrophic activity are considered to be promising candidates for the treatment of various neurodegenerative disease. Owing to the low-abundance metabolites in Illicium genus, there are few studies on their structural modifications, structure-activity relationships, and pharmacophoric motif. Herein, structural modifications were conducted on the hydroxyl groups at C-3 and C-6 positions of two majucin-type compounds neomajucin (1) and majucin (2), and 39 neomajucin/majucin based esters were synthesized and evaluated for their neurite outgrowth-promoting activities. Among all the target derivatives, compounds 1a, 1j, 1r, 2b, 2d, 3a, 3b, 3d and 3h displayed more potent neurite outgrowth-promoting activity than their precursors. Some interesting structure-activity relationships (SARs) were also observed. Moreover, compound 1a showed good neuroprotective effect on MPP+-induced PC12 cell damage. Finally, compounds 1a and 3a exhibited relatively no cytotoxicity to normal human H9C2 cardiac cells. This work will shed light on the development of neomajucin/majucin derivatives as potential neurotrophic agents.


Assuntos
Fatores de Crescimento Neural/farmacologia , Doenças Neurodegenerativas/tratamento farmacológico , Crescimento Neuronal/efeitos dos fármacos , Fármacos Neuroprotetores/farmacologia , Bibliotecas de Moléculas Pequenas/farmacologia , Animais , Diferenciação Celular/efeitos dos fármacos , Linhagem Celular , Relação Dose-Resposta a Droga , Humanos , Illicium/química , Estrutura Molecular , Fatores de Crescimento Neural/síntese química , Fatores de Crescimento Neural/química , Doenças Neurodegenerativas/metabolismo , Fármacos Neuroprotetores/síntese química , Fármacos Neuroprotetores/química , Células PC12 , Ratos , Bibliotecas de Moléculas Pequenas/síntese química , Bibliotecas de Moléculas Pequenas/química , Relação Estrutura-Atividade
15.
J Asian Nat Prod Res ; 24(1): 31-38, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33502248

RESUMO

Two new phenolic glycosides (1-2) and eleven known compounds (3-13) were isolated from the fruits of Illicium verum Hook.f. using silica-gel column and preparative middle pressure liquid chromatography (MPLC). The structures of the compounds were elucidated by NMR spectroscopic data. Among them, compounds 3, 5, and 10 were isolated from the family Magnoliaceae for the first time. Additionally, all the compounds were evaluated for their anti-complementary activities against the classical pathway (CP) and the alternative pathway (AP).


Assuntos
Illicium , Frutas , Glicosídeos/farmacologia , Estrutura Molecular , Fenóis/farmacologia
17.
Chem Biodivers ; 19(1): e202100868, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34837325

RESUMO

Two new seco-prezizaane-type sesquiterpenes, 2ß-hydroxy-6-deoxyneoanisatin (1) and 3,4-anhydro-2-oxo-1α-hydroxy-6-deoxyneoanisatin (2), and two new prenylated C6 -C3 compounds, illilanceofunones A (3) and B (4), were obtained from the fruits of Illicium lanceolatum, along with four known prenylated C6 -C3 compounds (5-8). Their structures were proposed through HR-ESI-MS, 1 H, 13 C, and 2D NMR data interpretation. Moreover, the absolute configuration of 1 and 2 were further assigned by single-crystal X-ray diffraction analysis and electronic circular dichroism (ECD) calculations, respectively. Illihenryipyranol A (6) exhibited neuroprotective activity against MPP+ -induced PC12 cell damage in a dose-dependent manner.


Assuntos
Illicium/química , Fármacos Neuroprotetores/química , Sesquiterpenos/química , Animais , Sobrevivência Celular/efeitos dos fármacos , Dicroísmo Circular , Frutas/química , Frutas/metabolismo , Illicium/metabolismo , Espectroscopia de Ressonância Magnética , Conformação Molecular , Fármacos Neuroprotetores/isolamento & purificação , Fármacos Neuroprotetores/farmacologia , Células PC12 , Extratos Vegetais/química , Prenilação , Ratos , Sesquiterpenos/isolamento & purificação , Sesquiterpenos/farmacologia , Espectrometria de Massas por Ionização por Electrospray
18.
Nat Prod Res ; 36(21): 5539-5544, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34949126

RESUMO

Two undescribed phenylpropenoid glycosides (1 - 2) and one known analogues (3) have been isolated and identified from the roots of Illicium dunnianum. The structures of these new compounds were elucidated by extensive spectroscopic analyses (1 D-, 2 D-NMR, HRESIMS, IR, UV) and chemical methods. The anti-inflammatory activities of all isolates were evaluated by measuring their inhibitory effects on PGE2 production in LPS stimulated RAW 264.7 macrophages.


Assuntos
Illicium , Illicium/química , Glicosídeos/química , Estrutura Molecular , Raízes de Plantas/química , Anti-Inflamatórios/farmacologia , Anti-Inflamatórios/análise
19.
Zhongguo Zhong Yao Za Zhi ; 46(22): 5848-5852, 2021 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-34951174

RESUMO

Three seco-prezizaane-type sesquiterpene lactones, one phenylpropanoid, and two lignans were isolated from the 95% ethanol extract of stems and branches of Illicium ternstroemioides with silica gel column chromatography, ODS column chromatography, and preparative HPLC. Based on the spectral data, they were identified as burmanicumolide D(1), veranisatin A(2), veranisatin B(3), dihydroconiferylalcohol(4), pinoresinol(5),(-)-matairesinol(6), respectively. Among them, compound 1 was a new seco-prezizaane-type sesquiterpene lactone, and 2-6 were obtained from this plant for the first time. None of these compounds display antiviral or cytotoxic activities.


Assuntos
Illicium , Sesquiterpenos , Antivirais , Lactonas , Estrutura Molecular , Compostos Fitoquímicos
20.
Rev Bras Parasitol Vet ; 30(4): e009321, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34910016

RESUMO

The essential oils (EOs) of Illicium verum and Pelargonium graveolens were evaluated for lethality, inhibition of development and residual efficacy against the flea Ctenocephalides felis felis. Their chemical composition was characterized by means of gas chromatography with a flame ionization and mass spectrometry detection. Mortality at different immature stages and among adult fleas was measured through in vitro filter paper tests at different concentrations of EOs. The chemical characterization of I. verum volatile oil showed that E-anethole (79.96%) was the major constituent, while the major compounds in P. graveolens were citronellol (29.67%) and geraniol (14.85%). Insecticidal activity against both immature and adult flea stages were observed. The EO of I. verum had insecticidal activity for approximately 18 days, while the EO activity of P. graveolens lasted for 13 days. The pulicidal activity of I. verum remained above 70% for up to 9 days, while the activity of P. graveolens was 41.7% for up to 2 days. Essential oils, especially that of I. verum, showed insecticidal activity for flea control at different life cycle stages and have potential for the development of ectoparasiticides (biopesticides) for veterinary use.


Assuntos
Ctenocephalides , Illicium , Óleos Voláteis , Pelargonium , Animais , Ctenocephalides/efeitos dos fármacos , Cromatografia Gasosa-Espectrometria de Massas/veterinária , Illicium/química , Óleos Voláteis/farmacologia , Pelargonium/química
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