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1.
Rev. bras. anestesiol ; 61(5): 607-609, set.-out. 2011.
Artigo em Português | LILACS | ID: lil-600953

RESUMO

JUSTIFICATIVA E OBJETIVOS: A gonadotrofina coriônica humana (HCG) e o hormônio tireotrófico (TSH) apresentam analogia entre suas estruturas, assim como seus receptores. Os altos níveis de HCG encontrados nas doenças trofoblásticas gestacionais podem induzir um quadro de hipertireoidismo secundário. O objetivo deste relato é apresentar um caso em que a administração de contraste iodado precipitou um quadro de crise tireotóxica. RELATO DO CASO: Paciente com mola hidatiforme completa foi admitida no centro cirúrgico com sangramento vaginal intenso após realização de tomografia com contraste iodado. Durante indução anestésica, paciente apresentou quadro compatível com crise tireotóxica. CONCLUSÕES: A incidência de quadros graves associados à doença trofoblástica gestacional tende a diminuir com seu diagnóstico precoce. Ainda que isso aconteça, o anestesiologista deve estar atento à possibilidade de crise tireotóxica nesses pacientes.


BACKGROUND AND OBJECTIVES: Human chorionic gonadotropin (HCG) and thyrotrophic hormone (TSH) have analogies in their structures, as well as in their receptors. The high levels of HCG seen in gestational trophoblastic diseases may induce secondary hyperthyroidism. The objective of this report was to present a case in which the administration of iodinated contrast triggered a thyrotoxic crisis. CASE REPORT: Patient with complete hydatidiform mole who was admitted to the operating room with severe vaginal bleeding after a tomographic exam with iodinated contrast. During anesthetic induction, the patient presented symptoms compatible with thyrotoxic crisis. CONCLUSIONS: The incidence of severe presentations associated with gestational trophoblastic disease tends to decrease with early diagnosis. Still, the anesthesiologist should be aware of the possibility of those patients developing thyrotoxic crisis.


JUSTIFICATIVA Y OBJETIVOS: La HCG y el TSH presentan una analogía entre sus estructuras, como también sus receptores. Los altos niveles de HCG encontrados en las enfermedades trofoblásticas de la gestación pueden inducir a un cuadro de hipertiroidismo secundario. El objetivo de este relato es presentar un caso en que la administración de contraste yodado precipitó un cuadro de crisis tirotóxica. RELATO DEL CASO: Paciente con mola hidatiforme completa que entró en quirófano con sangramiento vaginal intenso después de la realización de una tomografía con contraste yodado. Durante la inducción anestésica, la paciente presentó un cuadro compatible con la crisis tirotóxica. CONCLUSIONES: La incidencia de cuadros graves asociados a la enfermedad trofoblástica gestacional tiende a reducirse con su diagnóstico precoz. Pero incluso si eso ocurre, el anestesiólogo debe estar atento a la posibilidad de una crisis tirotóxica en esos pacientes.


Assuntos
Humanos , Feminino , Adolescente , Hipertireoidismo/complicações , Cuidados Intraoperatórios , Iodopiridonas , Mola Hidatiforme/complicações , Crise Tireóidea
2.
J Org Chem ; 76(21): 8930-43, 2011 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-21955144

RESUMO

The development of an innovative method to access enantiopure 2,4-disubstituted 6-hydroxy-1,6-dihydro-2H-pyridin-3-ones starting from D-glucal via the aza-Achmatowicz transformation has been described. These highly functionalized pyridin-3-ones have been utilized for the synthesis of contiguously substituted pyridines through a rapid and efficient Et(3)N/Ac(2)O promoted cyclo-elimination, aromatization cascade, allowing the facile assembly of important pyridine-based building blocks like 2-substituted 3-acetoxy-4-iodopyridines and enantiopure 2-substituted 3-acetoxy-4-pyridinemethanols possessing benzylic stereogenic centers, whose synthesis otherwise would be tedious. The utilization of commercially available sugars as starting materials, mild reaction conditions, catalytic transfer hydrogen (CTH) of α-furfuryl azide derivatives, transfer of chiral aryl/alkyl methanols from enulosides to pyridin-3-ones and pyridines, high yields, and short reaction times are key features of this method. The utility of the method has been further exemplified by demonstrating the usage of the 2-substituted 3-acetoxy-4-iodopyridine for the construction of biologically significant molecules like 2,7-disubstituted furo[2,3-c]pyridines and 7,7'-disubstituted 2,2'-bifuro[2,3-c]pyridines.


Assuntos
Iodopiridonas/química , Iodopiridonas/síntese química , Piridinas/química , Piridinas/síntese química , Piridonas/química , Piridonas/síntese química , Estrutura Molecular , Estereoisomerismo
3.
J Med Chem ; 52(23): 7473-87, 2009 Dec 10.
Artigo em Inglês | MEDLINE | ID: mdl-19645483

RESUMO

A series of C-5 methyl substituted 4-arylthio- and 4-aryloxy-3-iodopyridin-2(1H)-ones has been synthesized as new pyridinone analogues for their evaluation as anti-HIV inhibitors. The optimization at the 5-position was developed through an efficient use of the key intermediates 5-ethoxycarbonyl- and 5-cyano-pyridin-2(1H)-ones (14 and 15). Biological studies revealed that several compounds show potent HIV-1 reverse transcriptase inhibitory properties, for example, compounds 93 and 99 are active at 0.6-50 nM against wild type HIV-1 and a panel of major simple/double HIV mutant strains.


Assuntos
Fármacos Anti-HIV/síntese química , Fármacos Anti-HIV/farmacologia , HIV/efeitos dos fármacos , Iodopiridonas/síntese química , Iodopiridonas/farmacologia , Fármacos Anti-HIV/química , Linhagem Celular , HIV/enzimologia , HIV/genética , Transcriptase Reversa do HIV/antagonistas & inibidores , Transcriptase Reversa do HIV/genética , Humanos , Concentração Inibidora 50 , Iodopiridonas/química , Mutação , Bibliotecas de Moléculas Pequenas/síntese química , Bibliotecas de Moléculas Pequenas/química , Bibliotecas de Moléculas Pequenas/farmacologia
7.
Br J Radiol ; 59(707): 1079-82, 1986 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-3790893

RESUMO

The toxic effects of Hytrast were studied on the peritoneum of laboratory rats in order to define the lethal dose and possible causes of toxicity. The results show that Hytrast, due to its toxicity, should not be used in any clinical situation where gastrointestinal tract perforation or leakage is a possibility.


Assuntos
Iodopiridonas/toxicidade , Peritônio/efeitos dos fármacos , Abdome/patologia , Animais , Relação Dose-Resposta a Droga , Extravasamento de Materiais Terapêuticos e Diagnósticos/patologia , Masculino , Pâncreas/patologia , Peritônio/patologia , Radiografia Abdominal , Ratos
11.
Ann Emerg Med ; 14(3): 209-12, 1985 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-3977144

RESUMO

The endotracheal route has been used as a second route of choice for administration of emergency drugs for several years; however, the optimal technique for administration of drugs by this route has not been clearly defined. One important aspect of technique involves the question of how distribution to the distal-most endobronchial tree is influenced by initial depth of endotracheally administered drug instillation and use of forced manual hyperventilation. This study demonstrates that depth of instillation of drugs administered by the endotracheal route may not be an important factor in the delivery of medications to absorptive sites in the lung. It appears, however, that forced manual hyperventilation is essential to assure bilateral and optimal distal delivery of endotracheally administered medications.


Assuntos
Meios de Contraste , Intubação Intratraqueal , Iodopiridonas/administração & dosagem , Pulmão/diagnóstico por imagem , Propiliodona/administração & dosagem , Respiração Artificial/métodos , Animais , Cuidados Críticos , Cães , Radiografia
12.
Br J Radiol ; 57(682): 895-901, 1984 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-6487960

RESUMO

The reactions of seven contrast agents--pure barium sulphate, Micropaque, Gastrografin, Dionosil, Hytrast, Amipaque and Hexabrix--on the bronchi and lungs of rats were studied. This work was undertaken to find a safe gastrointestinal contrast agent for use in post-operative patients where aspiration may be an accompanying risk. Amipaque and Hexabrix produced no significant histological reaction in the lungs and would, therefore, appear to be suitable for use in such cases.


Assuntos
Meios de Contraste/toxicidade , Sistema Digestório/diagnóstico por imagem , Pulmão/efeitos dos fármacos , Animais , Sulfato de Bário/toxicidade , Brônquios/efeitos dos fármacos , Broncografia , Diatrizoato de Meglumina/toxicidade , Avaliação de Medicamentos , Iodopiridonas/toxicidade , Ácido Ioxáglico , Pulmão/patologia , Masculino , Metrizamida/toxicidade , Propiliodona/toxicidade , Ratos , Ratos Endogâmicos , Ácidos Tri-Iodobenzoicos/toxicidade
15.
Br J Dis Chest ; 77(1): 98-103, 1983 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-6860559

RESUMO

Severe reactions to oily propyliodone are rare. Side-effects are usually mild and self-limiting. Three cases are reported of early pulmonary reactions, the cause of which may be a chemical pneumonitis or possibly an allergic response to one of the components of the contrast medium. There was a good response to corticosteroid therapy in all three patients.


Assuntos
Iodopiridonas/efeitos adversos , Pneumopatias/induzido quimicamente , Óleos/efeitos adversos , Óleos Vegetais , Propiliodona/efeitos adversos , Adulto , Broncografia , Feminino , Humanos , Pneumopatias/diagnóstico por imagem , Masculino , Óleo de Amendoim
16.
Horm Res ; 17(3): 121-7, 1983.
Artigo em Inglês | MEDLINE | ID: mdl-6406336

RESUMO

Thyroid function was studied in 27 subjects who underwent bronchography with propyliodone (18-70 ml, containing 30% of organic iodine). Sustained elevations of serum non-hormonal iodine were observed, indicating that significant amounts of propyliodone were absorbed from the bronchial tree and also that elimination may take several weeks. During the period of anaesthesia, there was an increase in thyroxine-binding globulin and all thyroid hormones which was transient and probably reflected vascular response to the anaesthetic. T4-T3 conversion was inhibited with a nadir of T3 and a peak of rT3 occurring on the 2nd day after propyliodone exposure. FT4 increased gradually during the 2 weeks after bronchography, but remained within the normal range. 6 out of the 27 patients developed pathologic T4 levels, 3 elevated T3 levels, and 2 an abnormal response to thyrotropin-releasing hormone; these changes might have been confused with hyperthyroidism. None of the patients developed clinical thyrotoxicosis; however, in patients with autonomous thyroid tissue, the same precautions should be taken with propyliodone as with other iodine-containing agents which are known to induce hyperthyroidism in this situation.


Assuntos
Broncografia/efeitos adversos , Iodopiridonas/efeitos adversos , Propiliodona/efeitos adversos , Glândula Tireoide/fisiologia , Adulto , Proteínas Sanguíneas/metabolismo , Feminino , Humanos , Iodo/sangue , Masculino , Pessoa de Meia-Idade , Hormônio Liberador de Tireotropina , Tiroxina/sangue , Proteínas de Ligação a Tiroxina/metabolismo , Fatores de Tempo , Tri-Iodotironina/sangue , Tri-Iodotironina Reversa/sangue
18.
J Med Chem ; 24(1): 115-7, 1981 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-7205867

RESUMO

The synthesis and biological evaluation of 4-(aminomethyl)-6-(1,1-dimethylethyl)-2-iodo-3-pyridinol dihydrochloride (7b) are described. Compound 7b proved to be highly active as a saluretic diuretic in both rats and dogs.


Assuntos
Diuréticos/síntese química , Iodopiridonas/síntese química , Animais , Pressão Sanguínea/efeitos dos fármacos , Fenômenos Químicos , Química , Diuréticos/farmacologia , Cães , Eletrólitos/urina , Hipertensão/fisiopatologia , Iodopiridonas/farmacologia , Ratos
20.
Radiologe ; 19(7): 281-7, 1979 Jul.
Artigo em Alemão | MEDLINE | ID: mdl-91180

RESUMO

Cystography by double-contrast-technique as a simple and quick method of evaluating benign and malignant lesions of the urinary bladder is being described. 301 examinations were reviewed and are being discussed in regard to diagnostic value, indication, complication and radiation exposure of this method. A few typical cases are being demonstrated to illustrate the value of this method in the spectrum of other diagnostic methods in the work-up of urinary bladder lesions.


Assuntos
Meios de Contraste , Iodopiridonas , Propiliodona , Doenças da Bexiga Urinária/diagnóstico por imagem , Neoplasias da Bexiga Urinária/diagnóstico por imagem , Humanos , Masculino , Melanoma/diagnóstico por imagem , Pessoa de Meia-Idade , Hiperplasia Prostática/diagnóstico por imagem , Radiografia , Neoplasias Retais/diagnóstico por imagem , Neoplasias da Bexiga Urinária/secundário
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