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1.
Pediatr Dermatol ; 38(5): 1338-1339, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34338340

RESUMO

Cutaneous pigmentation due to the arthropod, Cydnidae (a.k.a. burrowing bug), is increasingly being reported in the literature. The transient nature of this pigmentation probably contributes to its underreporting. We report a case of an 8-year-old girl with a sudden onset of hyperpigmented lesions on her index finger, face, and neck due to burrowing bugs. We propose the term "transient pseudo-lentigines sign" to better describe this fleeting arthropod-induced pigmentation.


Assuntos
Lentigo , Transtornos da Pigmentação , Criança , Face , Feminino , Humanos , Transtornos da Pigmentação/induzido quimicamente , Transtornos da Pigmentação/diagnóstico , Pigmentação da Pele
3.
PLoS One ; 16(7): e0254772, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34283871

RESUMO

BACKGROUND: Melanocytic nevi have a complex evolution influenced by several endogenous and exogenous factors and are known risk factors for malignant melanoma. Interestingly, tobacco use seems to be inversely associated with melanoma risk. However, the association between tobacco use and nevi and lentigines has not yet been evaluated. METHODS: We investigated the prevalence of nevi, atypical nevi, and lentigines in relation to tobacco smoking in a cohort of 59 smokers and 60 age- and sex-matched nonsmokers, using a questionnaire and performing a total body skin examination by experts. RESULTS: No significant differences were detected between smokers and nonsmokers in the numbers of nevi, atypical nevi, and lentigines in sun-exposed areas (p = 0.966, 0.326, and 0.241, respectively) and in non-sun-exposed areas (p = 0.095, 0.351, and 0.546, respectively). CONCLUSION: Our results revealed no significant differences in the prevalence of nevi, atypical nevi, and lentigines between smokers and nonsmokers in sun-exposed and non-sun-exposed areas.


Assuntos
Lentigo/epidemiologia , Nevo Pigmentado/epidemiologia , Fumar Tabaco/efeitos adversos , Adulto , Idoso , Áustria , Estudos de Casos e Controles , Feminino , Humanos , Lentigo/metabolismo , Masculino , Melanoma/etiologia , Pessoa de Meia-Idade , Nevo/epidemiologia , Nevo/metabolismo , Nevo Pigmentado/metabolismo , Prevalência , Fatores de Risco , Neoplasias Cutâneas/etiologia , Inquéritos e Questionários , Fumar Tabaco/metabolismo , Fumar Tabaco/fisiopatologia
4.
Dermatol Ther ; 34(5): e15048, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34212464

RESUMO

Psoriasis is a systemic inflammatory disease commonly associated with postinflammatory hyper- and hypo-pigmentation. Psoriasis-related cytokines such as IL-17 and TNF can contribute to these pigmentation changes by regulating both the growth and pigment production of melanocytes. Here, we present the first reported the case of a patient with a 10-year history of severe psoriasis vulgaris, who developed multiple lentigines in areas of resolved psoriatic plaques during anti-IL-17A antibody secukinumab.


Assuntos
Lentigo , Transtornos da Pigmentação , Psoríase , Anticorpos Monoclonais Humanizados , Humanos , Psoríase/induzido quimicamente , Psoríase/diagnóstico , Psoríase/tratamento farmacológico
5.
BMJ Case Rep ; 14(6)2021 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-34167977

RESUMO

The Carney complex (CNC) is a rare autosomal dominant genetic complex that is characterised by multiple neoplasms consisting of neuroendocrine and cardiac tumours, with only 750 cases reported worldwide as of 2017. Cardiac tumours, in the context of the CNC, are of unique importance since the leading causes of death in patients with CNC are cardiac. To prevent sudden cardiac death and embolic events, a difficult diagnosis must be made and postdiagnostic screenings must be regular. We present a case of a 52-year-old man, with a medical history of pituitary microadenoma and facial lentiginosis, who presented with dyspnoea 2 months after suffering a cerebrovascular accident.


Assuntos
Complexo de Carney , Neoplasias Cardíacas , Lentigo , Mixoma , Neoplasias Hipofisárias , Complexo de Carney/complicações , Complexo de Carney/diagnóstico , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Mixoma/diagnóstico , Mixoma/diagnóstico por imagem , Neoplasias Hipofisárias/complicações , Neoplasias Hipofisárias/diagnóstico
6.
Int J Dermatol ; 60(11): 1376-1384, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34018611

RESUMO

BACKGROUND: Partial unilateral lentiginosis (PUL) is a rare acquired circumscribed hyperpigmentation characterized by multiple simple lentigines involving half of the body. Since the previous studies of PUL were mostly based on case reports and the current literature lacks well-designed retrospective studies that involve a large number of cases, PUL is not a well-defined entity, and differential diagnosis with nevus spilus is still difficult. This study aims to evaluate clinical and histopathological characteristics and treatment outcomes of PUL on head and neck area of Koreans. METHODS: Thirty-two patients with PUL on head and neck area were diagnosed clinicohistopathologically at the Asan Medical Center from 2004 to 2017. Their medical records, photographs, and biopsy specimens were reviewed, and immunohistochemical staining for protein kinase C (PKC)-ßΙΙ was evaluated for melanogenic activity. RESULTS: Four patients (12.5%) of PUL had congenital lesions, and 24 (75.0%) had age of onset younger than 10 years. Confluency of lentiginous lesions (100%) and mild to moderate background interlesional hyperpigmentation (90.6%) were observed. The lentiginous lesions showed increased melanocytes, melanophages, basal melanins, lentiginous hyperplasia, and perivascular inflammatory cells compared with background interlesional hyperpigmentation, and PKC-ßΙΙ was focally positive in 7 of 12 stained PUL lesions. Among the 16 patients who received laser treatments, 10 (62.5%) showed more than 50% of improvement. CONCLUSIONS: The findings of this study will allow for improved diagnosis of PUL and understanding of its features, which may facilitate proper management in the future.


Assuntos
Hiperpigmentação , Lentigo , Criança , Humanos , Lentigo/diagnóstico , Melanócitos , República da Coreia , Estudos Retrospectivos
7.
Dermatol Surg ; 47(5): e153-e158, 2021 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-33905392

RESUMO

BACKGROUND: Picosecond lasers are increasingly being investigated in treating pigmentation disorders because they may provide better treatment efficacy and comfort compared with nanosecond lasers. OBJECTIVE: This study aims to evaluate the efficacy and side effect of a novel 670-nm picosecond laser in the removal of benign pigmented lesions (BPLs) in individuals with Fitzpatrick skin types (FST) III and IV. MATERIALS AND METHODS: Fifteen subjects with solar lentigines and 7 subjects with ABNOMs received a single treatment with a 670-nm picosecond laser. Blinded physicians assessed the pigment clearance using a 5-category grading system scale. All subjects were evaluated at 1 month, 3 month, and 6 month after a single treatment. Adverse events were recorded at every follow-up visit. RESULTS: All subjects with lentigines had complete clearance (95%-100%) of lesions during 3-month follow-up after a single treatment session of 670-nm picosecond laser, whereas 75% of the subjects with ABNOMs noted fair lightning (25%-49%) of lesions. Mild hypopigmentation and hyperpigmentation were observed in 9% and 14% of the subjects, respectively, which resolved within 3 months after the treatment. CONCLUSION: The novel 670-nm picosecond laser is a safe and effective treatment for BPLs in subjects with FST III and IV with low rates of transient adverse effects.


Assuntos
Hiperpigmentação/cirurgia , Lasers de Estado Sólido/uso terapêutico , Lentigo/cirurgia , Adulto , Feminino , Humanos , Hiperpigmentação/etnologia , Lentigo/etnologia , Masculino , Pessoa de Meia-Idade , Segurança do Paciente , Estudos Prospectivos , Tailândia
9.
Medicina (Kaunas) ; 57(2)2021 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-33668564

RESUMO

Background and Objective: Little is known about the anti-pigmentation effects of whitening agents on solar lentigines. Epidermal growth factor (EGF) has been used as a booster for wound healing in the skin, and it has been suggested to have anti-pigmentation effects. This study aimed to evaluate the effect and safety of EGF-containing ointment for treating solar lentigines with a Q-switched (QS) 532 nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (Bluecore company, Seoul, Republic of Korea). Materials and Methods: Subjects who underwent QS 532 nm Nd:YAG laser treatment of solar lentigines were randomly assigned to treatment with an EGF ointment or petrolatum. After the laser procedure, the subjects were administered the test ointment twice a day for 4 weeks. The physician's assessment of the degree of pigment clearance and patient's satisfaction were assessed after 4 and 8 weeks. Additionally, the melanin index (MI), erythema index (EI), transepidermal water loss (TEWL), and post-inflammatory hyperpigmentation (PIH) were evaluated. This trial was registered with ClinicalTrials.gov (NCT04704245). Results: The blinded physician's assessment using 5-grade percentage improvement scale and patient's satisfaction were significantly higher in the study group than in the control group at the 4th and 8th weeks. The MI was significantly higher in the control group than in the study group at the 4th and 8th weeks. The EI and TEWL did not differ significantly between the two groups at either time point. The incidence of PIH was higher in the control group (37.5%) than in the EGF group (7.14%) at the 8th week. Conclusions: The application of EGF-containing ointment on facial solar lentigines with a QS 532 nm Nd:YAG laser showed efficient and safe therapeutic effects, with less PIH. Thus, EGF-containing ointment could be suggested as the promising adjuvant treatment strategy with a QS laser for solar lentigines.


Assuntos
Lentigo , Família de Proteínas EGF , Humanos , Lentigo/tratamento farmacológico , Pomadas , República da Coreia , Resultado do Tratamento
13.
Dermatol Ther ; 34(2): e14819, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33506629

RESUMO

Lasers are effective treatments for benign hyperpigmentations but may be difficult especially in darker skin type. In this randomized split-face controlled study on benign hyperpigmentations and pigmented scars, we compare the standard Single Pass (SP) emission with the MultiPass emission (MoveoPL) 755 alexandrite laser. Patients, skin types I-IV, with solar lentigines and ephelides of the face, chest, and hands and patients with pigmented scars of the legs, underwent laser treatment, by treating one side of the body or half scar using the SP and the other side using MoveoPL. Improvements according to a grading score system, side effects, and patient satisfaction were recorded. About 63 patients were enrolled. An overall improvement of benign hyperpigmentations and pigmented scars was recorded, with a grading score (±SD) of 2.8 ± 0.8 for SP and 3.6 ± 0.5 for MoveoPL (range, 0-4). SP emission showed best results in skin types I-II whereas MotusPL obtained successfully results in all the phototypes analyzed (types I-IV). Patients preferred MoveoPL as it was associated with fewer side effects. Both standard SP and MoveoPL emission are effective and safe. MoveoPL showed a higher efficacy and safety profile for the treatment of hyperpigmentations.


Assuntos
Hiperpigmentação , Lasers de Estado Sólido , Lentigo , Cicatriz/etiologia , Cicatriz/terapia , Humanos , Hiperpigmentação/etiologia , Lasers de Estado Sólido/efeitos adversos , Pele , Resultado do Tratamento
14.
BMJ Case Rep ; 14(1)2021 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-33414123

RESUMO

Carney Complex (CNC) is a rare syndrome characterised by skin pigmentation, endocrine over activity and myxomas, with the median age of detection being 20 years. We present a case of CNC diagnosed in infancy after being noted to have multiple lentigines over his face, abdomen, back and thighs at birth. We consider the differential diagnoses of similar cutaneous presentations in the well neonate and review the prognosis and suggested surveillance of patients with CNC.


Assuntos
Complexo de Carney/patologia , Lentigo/congênito , Lentigo/patologia , Humanos , Recém-Nascido , Masculino
17.
Microscopy (Oxf) ; 70(2): 224-231, 2021 Mar 24.
Artigo em Inglês | MEDLINE | ID: mdl-32991711

RESUMO

Senile lentigo or age spots are hyperpigmented macules of skin that commonly develop following long-term exposure to ultraviolet radiation. This condition is caused by accumulation of large numbers of melanosomes (melanin granules) produced by melanocytes within neighboring keratinocytes. However, there is still no consensus regarding the melanosome transfer mechanism in senile lentigo. To date, most pathohistological studies of skin have been two-dimensional and do not provide detailed data on the complex interactions of the melanocyte-keratinocyte network involved in melanosome transfer. We performed a three-dimensional reconstruction of the epidermal microstructure in senile lentigo using three different microscopic modalities to visualize the topological melanocyte-keratinocyte relationship and melanosome distribution. Confocal laser microscopy images showed that melanocyte dendritic processes are more frequently branched and elongated in senile lentigo skin than in normal skin. Serial transmission electron micrographs showed that dendritic processes extend into intercellular spaces between keratinocytes. Focused ion beam-scanning electron micrographs showed that dendritic processes in senile lentigo encircle adjacent keratinocytes and accumulate large numbers of melanosomes. Moreover, melanosomes transferred to keratinocytes are present not only in the supranuclear area but throughout the perinuclear area except on the basal side. The use of these different microscopic methods helped to elucidate the three-dimensional morphology and topology of melanocytes and keratinocytes in senile lentigo. We show that the localization of melanosomes in dendritic processes to the region encircling recipient keratinocytes contributes to efficient melanosome transfer in senile lentigo.


Assuntos
Queratinócitos/ultraestrutura , Lentigo/patologia , Melanócitos/ultraestrutura , Melanossomas/ultraestrutura , Pele/patologia , Adulto , Idoso , Espaço Extracelular/fisiologia , Feminino , Humanos , Imageamento Tridimensional/métodos , Masculino , Microscopia Confocal , Microscopia Eletrônica de Transmissão/métodos , Pessoa de Meia-Idade , Raios Ultravioleta/efeitos adversos
18.
Oral Oncol ; 112: 105017, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-32988748

RESUMO

We present a rare case of intraoral atypical lentiginous melanocytic lesion affecting a pediatric patient, in which the diagnosis of lentiginous junctional melanocytic nevus with cytologic atypia was favored. The main differential diagnosis is lentiginous melanoma, which is a slowly progressing lesion, affecting mainly older adults, and microscopically presenting lentiginous growth pattern of moderately atypical melanocytes, with focal nesting and pagetoid spread. It is strongly recommended that melanocytic lesions showing features of atypical lentiginous growth pattern should be treated with wide excision; however, the impact of these guidelines on pediatric patients needs to be better defined with the report of further cases.


Assuntos
Lentigo/patologia , Melanócitos/patologia , Neoplasias Bucais/patologia , Nevo Pigmentado/patologia , Pré-Escolar , Humanos , Lentigo/cirurgia , Masculino , Mucosa Bucal/patologia , Neoplasias Bucais/cirurgia , Nevo Pigmentado/cirurgia
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