Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 1.368
Filtrar
1.
Mymensingh Med J ; 31(1): 24-30, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34999675

RESUMO

Lymphadenopathy is a common problem encountered in day to day clinical practices in Bangladesh. It is an abnormal increase in size and/or altered consistency of lymph nodes. The condition generally is not a disease itself but a symptom of one of many possible underlying problems. So it is very much essential to achieve a correct diagnosis of patients presenting with lymphadenopathy. This cross sectional study carried out at the Department of Medicine, Mymensingh Medical College Hospital (MMCH), Mymensingh over a period of 6 months from January 2014 to June 2014. This study was carried out to evaluate the clinical presentations and to see the ultimate diagnosis by appropriate investigations of lymphadenopathy patients. It is a male predominance study. Metastatic carcinoma (Met. Ca) belonged to relatively higher age group, tuberculosis (TB) and acute leukaemias belonged to younger age group and lymphoma belonged to middle age group. Among 50 cases metastatic carcinoma comprises total 14(28%), lymphoma 13(26%), tuberculosis (TB) 12(24%), acute leukaemia 7(14%), non-specific (Non Sp.) 4(8%) cases. Among lymphoma non Hodgkin's lymphoma (NHL) was 10 (20%) then Hodgkin's disease (HD) was 3(6%) and among acute leukaemia acute lymphoblastic leukaemia (ALL) was 5(10%) and acute myeloblastic leukaemia (AML) was 2(4%) cases. Most of the patients belong to younger age groups, 32% cases were from 18-30 years. Most of the patients had generalized lymphadenopathy. Biopsy of lymph node was done in 60% cases. Fine needle aspiration cytology (FNAC) was done in 24% cases. Bone marrow study (BMD) was done in 14% cases include all cases of leukemia. Among 50 patients correct clinical diagnosis were found 100% cases of ALL and non-specific infection, 80% cases of metastatic carcinoma, 66.66% cases of AML and NHL, 62.5% cases of TB, 50% cases of HD. AML and ALL were diagnosed by bone marrow study. Over all 70% of clinical diagnosis were found correct in this study. In conclusion malignancy, lymphoma and tuberculosis were the most common cause of lymphadenopathy patients. Most of the cases were diagnosed by taking appropriate history and examination but FNAC, biopsy and bone marrow study were need for final diagnosis.


Assuntos
Linfonodos , Linfadenopatia , Adolescente , Adulto , Biópsia por Agulha Fina , Estudos Transversais , Humanos , Linfadenopatia/diagnóstico , Masculino , Pessoa de Meia-Idade , Centros de Atenção Terciária , Adulto Jovem
2.
JAAPA ; 35(1): 29-32, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34939587

RESUMO

ABSTRACT: The finding of lymphadenopathy on physical examination and radiographically can suggest a wide range of differential diagnoses for patients, including a benign inflammatory process, infection, or malignancy. This article describes a patient with a history of Hodgkin lymphoma who developed postremission left axillary lymphadenopathy caused by deposits of tattoo ink in the node.


Assuntos
Doença de Hodgkin , Linfadenopatia , Tatuagem , Diagnóstico Diferencial , Doença de Hodgkin/complicações , Humanos , Tinta , Linfadenopatia/etiologia , Tatuagem/efeitos adversos
3.
Spectrochim Acta A Mol Biomol Spectrosc ; 264: 120216, 2022 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-34364036

RESUMO

This study highlights the potential of surface-enhanced Raman scattering (SERS) to differentiate between B-cell lymphoma (BCL), T-cell lymphoma (TCL), lymph node metastasis of melanoma (Met) and control (Ctr) samples based on the specific SERS signal of DNA extracted from lymph node tissue biopsy. Differences in the methylation profiles as well as the specific interaction of malignant and non-malignant DNA with the metal nanostructure are captured in specific variations of the band at 1005 cm-1, attributed to 5-methylcytosine and the band at 730 cm-1, attributed to adenine. Thus, using the area ratio of these two SERS marker bands as input for univariate classification, an area under the curve (AUC) of 0.70 was achieved in differentiating between malignant and non-malignant DNA. In addition, DNA from the BCL and TCL groups exhibited differences in the area of the SERS band at 730 cm-1, yielding an AUC of 0.84 in differentiating between these two lymphadenopathies. Lastly, using multivariate data analysis techniques, an overall accuracy of 94.7% was achieved in the differential diagnosis between the BCL, TCL, Met and Ctr groups. These results pave the way towards the implementation of SERS as a novel tool in the clinical setting for improving the diagnosis of malignant lymphadenopathy.


Assuntos
Metilação de DNA , Linfadenopatia , DNA/genética , Diagnóstico Diferencial , Humanos , Análise Espectral Raman
4.
Pediatrics ; 149(1)2022 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-34972223

RESUMO

A 9-year-old girl presented to her primary care pediatrician via telemedicine during the initial months of the coronavirus disease 2019 pandemic because of 4 days of warmth perceived by her mother, decreased energy, and a new rash on her upper extremities. After 10 additional days of documented fever >38°C, worsening fatigue, and 1 day of nausea, vomiting, and diarrhea, she was allowed to schedule an in-person visit with her pediatrician after testing negative for severe acute respiratory syndrome coronavirus 2. She appeared ill on arrival to clinic, and her pediatrician recommended evaluation in an emergency department. Her initial laboratory testing revealed nonspecific elevation in several inflammatory markers and leukopenia, and she responded well to intravenous hydration. Over the next 2 weeks, her fever persisted, constitutional symptoms worsened, and she developed progressively painful cervical lymphadenopathy and pancytopenia. She was evaluated in clinic by several specialists and eventually was urged to present to the emergency department again, at which time she was admitted to the PICU. After consulting additional specialists and waiting for laboratory results, the team reached a definitive diagnosis and initiated therapy; however, she experienced rapid clinical decline shortly thereafter. The specialists who assisted with identification of the underlying etiology of her symptoms were able to work together to manage the subsequent complications.


Assuntos
Exantema , Febre , Unidades de Terapia Intensiva Pediátrica , Lúpus Eritematoso Sistêmico/diagnóstico , Telemedicina , COVID-19/complicações , COVID-19/diagnóstico , Criança , Progressão da Doença , Exantema/diagnóstico , Exantema/etiologia , Feminino , Febre/etiologia , Linfadenite Histiocítica Necrosante/diagnóstico , Humanos , Lúpus Eritematoso Sistêmico/sangue , Lúpus Eritematoso Sistêmico/complicações , Linfadenopatia/diagnóstico , Linfadenopatia/etiologia , Pancitopenia/diagnóstico , Avaliação de Sintomas , Síndrome de Resposta Inflamatória Sistêmica/diagnóstico
7.
BMC Surg ; 21(1): 416, 2021 Dec 14.
Artigo em Inglês | MEDLINE | ID: mdl-34906107

RESUMO

BACKGROUND: To investigate the value of multimodal ultrasonography in differentiating tuberculosis from other lymphadenopathy. METHODS: Sixty consecutive patients with superficial lymphadenopathy treated at our hospital from January 2017 to December 2018 were categorized into four types based on the color Doppler ultrasound, five types based on contrast-enhanced ultrasound, and five types based on elastography. Sensitivity and specificity were calculated of all the three imaging, including color Doppler examination, contrast-enhanced ultrasound and one individual multimodal method, for detecting lymph nodes. RESULTS: A total of 60 patients were included in the final analysis. Of those, Mycobacterium tuberculosis was positive in 38 patients and negative in 22 patients. Among the 38 patients who were positive for Mycobacterium tuberculosis, of which 23 had a history of pulmonary tuberculosis, accounting for 60.53% of the positive cases, and the remaining patients did not combine lesions of other organs. Among the 60 superficial lymph nodes, 63.3% presented with tuberculous lymphadenitis. The sensitivity, specificity, and accuracy of the color Doppler examination were 73.68%, 68.18%, and 71.67%, respectively. The sensitivity, specificity and accuracy of contrast-enhanced ultrasound were 89.47%, 63.64% and 80.00%, respectively. The sensitivity, specificity and accuracy of the elastography were 63.16%, 63.64% and 63.33%, respectively. The sensitivity, specificity and accuracy of one individual multimodal method were 42.11%, 95.45% and 61.67%, respectively. The sensitivity, specificity and accuracy of all modes combined were 100.00%, 27.27% and 73.33%, respectively. CONCLUSION: Multimodal ultrasonography has high predictive value for the differential diagnosis of superficial tuberculous lymphadenitis.


Assuntos
Linfadenite , Linfadenopatia , Tuberculose dos Linfonodos , Diagnóstico Diferencial , Humanos , Linfonodos , Tuberculose dos Linfonodos/diagnóstico por imagem , Ultrassonografia
8.
Oncología (Ecuador) ; 31(3): 234-242, 30-diciembre-2021.
Artigo em Espanhol | LILACS | ID: biblio-1352468

RESUMO

Se define carcinoma de cabeza y cuello (CCC) de primario desconocido al cuadro de adenopatía cervical en que, luego de examen físico, estudios de imágenes y panendoscopía con biopsias, no se encuentra el tumor primario pero sí la confirmación de malignidad de la adenomegalia. Son infrecuentes, por lo que estudios prospectivos que arrojen resultados estadísticamente significativos no están disponibles actualmente, y el tratamiento definitivo es aún motivo de controversia. Al ser la radioterapia un tratamiento dirigido es imprescindible definir adecuadamente los volúmenes blanco de tratamiento; es ideal el hallazgo del tumor primario, pero en muchos casos a pesar de un estudio escalonado, exhaustivo y multidisciplinar esto no se logra. Esto motiva el debate de qué regiones tratar, dosis, fraccionamiento y modalidad (exclusiva, adyuvante, en concurrencia). Hasta el momento el tratamiento de ganglios cervicales y mucosa de alto riesgo parece ser la estrategia con mejor control locorregional.


Head and neck carcinoma (HNC) of unknown primary is a clinical condition defined as a cervical adenopathy for which, after physical examination, imaging studies and panendoscopy with biopsies, the primary tumor is not found, but there is confirmed malignancy of the adenomegaly. It is infrequent, so prospective studies that yield statistically significant results are not currently available, and definitive treatment is still controversial. Since radiation therapy is a targeted treatment, it is essential to adequately define treatment target volumes; the discovery of the primary tumor is ideal, but in many cases, despite a phased, exhaustive and multidisciplinary study, this is not achieved. This motivates the debate on which regions to treat, dose, fractionation and modality (exclusive, adjuvant, concurrent). Until now, the treatment of high-risk cervical nodes and mucosa seems to be the strategy with the best locoregional control.


Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Idoso , Radioterapia , Neoplasias de Cabeça e Pescoço , Carcinoma de Células Escamosas , Linfadenopatia
9.
BMJ Case Rep ; 14(12)2021 Dec 30.
Artigo em Inglês | MEDLINE | ID: mdl-34969786

RESUMO

A 25-year-old woman with an extensive travel history developed chronic cough and multiple lung nodules. The lung biopsy revealed lymphoid interstitial pneumonia. The patient later developed cervical lymphadenopathy, arthritis and livedo reticularis, then systemic lupus erythematosus was diagnosed with positive double-stranded DNA and low complement. The patient's symptoms responded to prednisolone and azathioprine.


Assuntos
Doenças Pulmonares Intersticiais , Lúpus Eritematoso Sistêmico , Linfadenopatia , Adulto , Feminino , Humanos , Doenças Pulmonares Intersticiais/diagnóstico por imagem , Doenças Pulmonares Intersticiais/tratamento farmacológico , Lúpus Eritematoso Sistêmico/complicações , Lúpus Eritematoso Sistêmico/diagnóstico , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Prednisolona/uso terapêutico
10.
Am J Case Rep ; 22: e934752, 2021 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-34921129

RESUMO

BACKGROUND Benign tumors of the lymph nodes are rare and are not usually considered in the differential diagnosis in cases of lymphadenopathy because reactive hyperplasia, lymphoma, and metastatic carcinoma are the most likely causes of enlarged nodes. Intranodal palisaded myofibroblastoma (IPM) is a very rare benign mesenchymal tumor of the lymph nodes most often affecting but not limited to the inguinal region, with up to 92 cases reported in the English literature. The cell of origin is the intranodal differentiated smooth muscle cell or myofibroblast. Although the pathophysiology of IPM remains unclear, theories about viral oncogenesis and mutational changes in the ß-catenin gene with subsequent abnormal expression of ß-catenin and cyclin D1 have been raised. CASE REPORT We report a case of IPM in a 48-year-old man who presented with a mass in the left groin, with inconclusive imaging. The typical histologic findings of smooth muscle actin, cyclin D1, and ß-catenin positive intranodal spindle cell proliferation with characteristic palisades, amianthoid fibers, collagenous bodies, lack of atypia, and very low mitotic count, together with characteristic profile on ancillary testing, confirmed the diagnosis. In addition to staining with smooth muscle actin, cyclin D1 and ß-catenin, immunohistochemical studies showed focal positivity with desmin, a finding previously reported in 2 of the published cases. Surgical excision is usually curative, with a 6% recurrence rate and no reported cases of locally aggressive disease or malignant transformation. CONCLUSIONS Although rare, IPM should be included in the differential diagnosis of isolated lymphadenopathy.


Assuntos
Linfadenopatia , Neoplasias de Tecido Muscular , Neoplasias , Virilha , Humanos , Linfonodos , Masculino , Pessoa de Meia-Idade , Neoplasias de Tecido Muscular/diagnóstico
12.
Am J Case Rep ; 22: e933377, 2021 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-34802030

RESUMO

BACKGROUND Kikuchi-Fujimoto disease (KFD) is a rare benign and usually local lymphadenopathy that typically occurs in young women. Patients with it usually have non-specific symptoms, such as fever in the afternoon, cervical lymphadenitis, and weight loss. Posterior cervical lymphadenopathy is the most common manifestation of KFD. The symptoms often last for a few weeks and then resolve spontaneously. The cause of KFD is unknown; however, it is considered to be related to some infectious agents, as well as several autoimmune diseases. Because of the non-specific symptoms and the rarity of KFD, the cervical lymphadenopathy associated with it can be misdiagnosed as coming from a more common condition. Making a correct diagnosis requires histology of the affected lymph nodes. CASE REPORT Here, we describe the case of a 25-year-old Vietnamese woman who presented with mild fever in the afternoons and enlarged cervical lymph nodes with no local sign of inflammation. She was initially believed to have tubercular lymphadenitis because of her symptoms and the high prevalence of tuberculosis in Vietnam. However, she had no respiratory symptoms and tested negative on QuantiFERON-TB Gold. Pathology from the patient's lymph node specimen showed an abnormal inflammatory reaction in the tissue. Her lesions were suspected to have been caused by KFD and she was treated successfully with nonsteroidal anti-inflammatory drug (NSAID) therapy. CONCLUSIONS KFD is a benign disease that manifests with common symptoms. The diagnosis is based on biopsy of a specimen and pathology results. No treatment is required in patients who have no symptoms. Patients with symptoms usually respond well to a short course of NSAID therapy.


Assuntos
Linfadenite Histiocítica Necrosante , Linfadenite , Linfadenopatia , Adulto , Biópsia , Feminino , Linfadenite Histiocítica Necrosante/diagnóstico , Humanos , Linfonodos , Linfadenopatia/diagnóstico
13.
Pan Afr Med J ; 40: 60, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34795839

RESUMO

Thyroid heterotopia is an abnormal localization of normal thyroid tissue coexisting with a normal organ on a normal localization. It is a rare condition with a frequency that is not well known in the literature. We report a case of thyroid heterotopia in a 30 month-old girl referred for a painless lower antero-cervical nodule that has been developing for one year with past history no contributory. The clinical examination found a subcutaneous formation mobile in relation to the different deep and superficial planes with bilateral angulomandibular micro-lymphadenopathy. Ultrasounds of the soft parts of the neck showed hypoechogenic tissue reminiscent of thyroid tissue, the thyroid was in place. The thyroid hormone profile was normal. In the absence of a functional scintigraphy device, the diagnosis was confirmed with a pathology exam after surgery. We discuss the diagnostic relevance of thyroid heterotopia in front of any anterior nodular formation of the neck.


Assuntos
Coristoma/diagnóstico por imagem , Linfadenopatia/diagnóstico por imagem , Glândula Tireoide/diagnóstico por imagem , Pré-Escolar , Coristoma/cirurgia , Feminino , Humanos , Pescoço/diagnóstico por imagem
15.
Korean J Radiol ; 22(12): 1938-1945, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34719892

RESUMO

Breast radiologists are increasingly seeing patients with axillary adenopathy related to COVID-19 vaccination. Vaccination can cause levels I-III axillary as well as cervical lymphadenopathy. Appropriate management of vaccine-related adenopathy may vary depending on clinical context. In patients with current or past history of malignancy, vaccine-related adenopathy can be indistinguishable from nodal metastasis. This article presents imaging findings of oncology patients with adenopathy seen in the axilla or neck on cross-sectional imaging (breast MRI, CT, or PET-CT) after COVID-19 vaccination. Management approach and rationale is discussed, along with consideration on strategies to minimize false positives in vaccinated cancer patients. Time interval between vaccination and adenopathy seen on breast MRI, CT, or PET-CT is also reported.


Assuntos
Neoplasias da Mama , COVID-19 , Linfadenopatia , Vacinas , Axila , Neoplasias da Mama/diagnóstico por imagem , Vacinas contra COVID-19 , Feminino , Fluordesoxiglucose F18 , Humanos , Linfadenopatia/diagnóstico por imagem , Imageamento por Ressonância Magnética , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , SARS-CoV-2
16.
Clin Nucl Med ; 46(12): 1011-1012, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-34735411

RESUMO

ABSTRACT: A 50-year-old woman with stage IV sigmoid adenocarcinoma presented for restaging FDG PET/CT status post neoadjuvant chemotherapy/immunotherapy and diverting sigmoid colostomy. FDG PET/CT demonstrated FDG uptake in the known sigmoid mass and in abdominopelvic lymph node metastases. Bilateral, asymmetric, hypermetabolic axillary lymphadenopathy was also observed, an atypical pattern of spread for colon cancer. Further investigation revealed the patient had received both doses of COVID-19 vaccine in the 2 months prior to presentation. The authors discuss immunogenic nodal hypermetabolism following vaccination against COVID-19 and incorporating vaccination history to aid in PET/CT interpretation, especially in malignancies involving the axillae.


Assuntos
COVID-19 , Linfadenopatia , Vacinas contra COVID-19 , Feminino , Fluordesoxiglucose F18 , Humanos , Linfadenopatia/diagnóstico por imagem , Metástase Linfática , Pessoa de Meia-Idade , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , SARS-CoV-2 , Vacinação
20.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 52(5): 859-861, 2021 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-34622606

RESUMO

In this study, we report on three immunocompetent children with pulmonary cryptococcosis presenting mediastinal lymphadenopathy as the prominent manifestation. All three children were otherwise healthy previously. Two children had a history of exposure to pigeons and poultry. All three presented persistent fever accompanied by mild cough. There were no obvious positive signs in the lungs. One patient had enlarged cervical lymph nodes. All three had elevated levels of white blood cells, neutrophil count, and C-reactive protein (CRP). The levels of IgG, IgM, IgA, IgE and T cell subsets were normal in all cases, and they were all tested negative for HIV antibody. Two children were tested positive for serum cryptococcal antigen (sCRAG). The chest X-ray and pulmonary CT findings of the three patients all demonstrated marked enlargement of mediastinal lymph nodes, and one patient had nodules in the parenchyma. Surgical biopsies of mediastinal lymph nodes were performed in two children and large numbers of capsule spores were found in the histological examination. In the three cases, definitive diagnosis of pulmonary cryptococcosis were made in two patients, and clinical diagnosis was made in the third patient. Two patients were treated with fluconazole alone. The other patient whose condition was complicated with spleen infection was treated with fluconazole combined with amphotericin B for the first month, and was then given fluconazole for maintenance treatment. The overall treatment course lasted 5-9 months and all three were cured eventually. In conclusion, immunocompetent children with pulmonary cryptococcosis may present mediastinal lymphadenopathy as a prominent or isolated manifestation, which should be considered in differential diagnosis. Treatment with fluconazole alone or in combination with amphotericin B when it was necessary showed good therapeutic outcomes.


Assuntos
Criptococose , Linfadenopatia , Criança , Tosse , Criptococose/complicações , Criptococose/diagnóstico , Criptococose/tratamento farmacológico , Humanos , Pulmão , Linfonodos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...