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1.
Ann Diagn Pathol ; 61: 152052, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36270241

RESUMO

Secretory carcinoma (SC) is a recently recognized type of salivary gland tumor characterized by t(12;15) (p13;q25) translocation resulting in an ETV6-NTRK3 gene fusion. Most SCs are located in a main salivary gland, and primary sinonasal secretary carcinoma is rare. We describe three cases of primary SC in the sinonasal cavity with high-grade transformation (HGT) in one case, and the first case in the pharynx. All tumors comprised slightly atypical cells with solid, tubular, microcystic growth patterns. The case with HGT included two components with distinct sharp boundaries and comedo necrosis, high mitotic figures and obvious cellular atypia. Tumor cells were positive for vimentin, S100, and Gata-3 and negative for p63 and DOG-1. Three cases showed nuclear staining of pan-TRK and one showed cytoplasmic staining. All cases harbored ETV6 gene rearrangement, and ETV6-NTRK3 gene fusion was detected in three cases. Most patients were treated with radical resection and adjuvant therapy. After excision, all remained tumor-free for 65-164 months (medium 98.5 months). SC in the sinonasal cavity and pharynx is a low-grade malignant tumor with histologic features overlapping those of other salivary gland tumors. Immunohistochemical analysis and fluorescence in situ hybridization are useful techniques for its differential diagnosis.


Assuntos
Carcinoma , Carcinoma Secretor Análogo ao Mamário , Neoplasias das Glândulas Salivares , Humanos , Hibridização in Situ Fluorescente , Estudos Retrospectivos , Imuno-Histoquímica , Faringe/química , Faringe/patologia , Proteínas de Fusão Oncogênica/genética , Carcinoma/diagnóstico , Carcinoma/genética , Carcinoma/patologia , Neoplasias das Glândulas Salivares/diagnóstico , Neoplasias das Glândulas Salivares/genética , Neoplasias das Glândulas Salivares/patologia , Biomarcadores Tumorais/genética , Biomarcadores Tumorais/análise , Carcinoma Secretor Análogo ao Mamário/patologia
2.
J Pak Med Assoc ; 72(5): 950-953, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35713062

RESUMO

Mammary Analogue Secretory Carcinoma (MASC) is a rare pathology of the salivary gland, most commonly involving the parotid gland. The objective of this study was to identify the characteristic features of MASC and its treatment outcomes. A retrospective review of 12 patients with histological diagnosis of MASC, who were managed between 2010 to 2019, was carried out at the Shaukat Khanum Memorial Cancer Hospital & Research Centre, Lahore. Their mean age was 34±16 years. There were 9 (75%) male and 3 (25%) female patients. Painless slow growing swelling was the most common presenting symptom. All the patients had undergone surgical excision with or without neck dissection, followed by adjuvant treatment. Of these, six patients had T2 tumours, while four had cervical lymph node metastasis. The mean follow-up period was 23±21 months. Local recurrence was seen in one patient. MASC is considered a low-grade tumour with good prognosis which can be treated with curative intent of surgery followed by radiotherapy effectively.


Assuntos
Carcinoma Secretor Análogo ao Mamário , Neoplasias das Glândulas Salivares , Adolescente , Adulto , Feminino , Humanos , Metástase Linfática , Masculino , Carcinoma Secretor Análogo ao Mamário/patologia , Pessoa de Meia-Idade , Paquistão , Glândula Parótida/patologia , Neoplasias das Glândulas Salivares/patologia , Adulto Jovem
4.
Einstein (Sao Paulo) ; 20: eRC5724, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35170709

RESUMO

Mammary analogue secretory carcinoma is a rare neoplasm usually confused with other neoplasms in the salivary glands region. It has great similarity with the breast carcinoma. We report a case of a patient who presented with gingival submucosal bleeding and lesion, with the initial histopathological examination revealing salivary gland neoplasm of low crane. Computed tomography revealed the lesion near the tooth 27, with extension to the floor of the left maxillary sinus and to the palate mucosa. Resection of the infra-structure was performed, with a diagnosis of breast cancer secretory carcinoma in the minor salivary gland.


Assuntos
Carcinoma , Carcinoma Secretor Análogo ao Mamário , Neoplasias das Glândulas Salivares , Carcinoma/diagnóstico por imagem , Carcinoma/cirurgia , Humanos , Carcinoma Secretor Análogo ao Mamário/diagnóstico por imagem , Neoplasias das Glândulas Salivares/diagnóstico por imagem , Neoplasias das Glândulas Salivares/cirurgia , Glândulas Salivares , Glândulas Salivares Menores/diagnóstico por imagem
5.
Ear Nose Throat J ; 101(5): NP212-NP217, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32951456

RESUMO

Mammary analogue secretory carcinoma (MASC) of the salivary gland is a rare tumor that was first described by Skalova et al in 2010, and since then, only a few hundred cases have been reported in the literature. Prior to Skalova's report, MASC was histologically misclassified as acinic cell carcinoma (ACC), pleomorphic adenoma, mucoepidermoid carcinoma, or adenocarcinoma, not otherwise specified. Mammary analogue secretory carcinoma has a low incidence rate overall, accounting for less than 0.3% of all salivary gland tumors. Histopathologic and cytogenic analysis of MASC is identical to secretory carcinoma of the breast, leading to the proposed name by Skalova. The purpose of this case presentation is to describe an atypical presentation of MASC, to compare this case with the classic description of MASC, and to contrast the various features of MASC to ACC in order to improve the accuracy of future diagnoses and help guide treatment.


Assuntos
Carcinoma de Células Acinares , Carcinoma Mucoepidermoide , Carcinoma Secretor Análogo ao Mamário , Neoplasias das Glândulas Salivares , Carcinoma Mucoepidermoide/patologia , Humanos , Lábio , Masculino , Carcinoma Secretor Análogo ao Mamário/diagnóstico , Carcinoma Secretor Análogo ao Mamário/patologia , Neoplasias das Glândulas Salivares/diagnóstico , Neoplasias das Glândulas Salivares/patologia , Adulto Jovem
6.
Pediatr Dev Pathol ; 25(2): 155-161, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34606389

RESUMO

Secretory carcinoma (SC), previously known as mammary analogue secretory carcinoma, is a rare salivary gland neoplasm that typically presents as a slow-growing painless lesion in the head and neck. SC occurs mainly in adults but has been described in children with the youngest reported patient diagnosed at five years of age. In children the gender distribution has been reported as female to male ratio of 1:1.2. SC is generally considered a low-grade malignancy with characteristic morphological features and immunological profile. SC also harbors ETV6-NTRK3 fusion (t(12;15)(p13:q25)). Surgical resection with or without lymph node dissection is the standard treatment, with generally favorable clinical outcomes. Here we present a single institution case series of six patients (ages 9-21) with SC and a review of the previously described pediatric cases. Our small series showed male predominance in pediatric patients with predominantly low-grade and stage tumors. All cases underwent complete surgical resections and when follow up is available there was no evidence of recurrences or metastases. To the best of our knowledge, this is the only SC case series comprised exclusively of pediatric and youth patients.


Assuntos
Carcinoma , Carcinoma Secretor Análogo ao Mamário , Neoplasias das Glândulas Salivares , Adolescente , Biomarcadores Tumorais/genética , Neoplasias da Mama , Carcinoma/patologia , Criança , Feminino , Humanos , Masculino , Carcinoma Secretor Análogo ao Mamário/patologia , Neoplasias das Glândulas Salivares/diagnóstico , Neoplasias das Glândulas Salivares/genética , Neoplasias das Glândulas Salivares/cirurgia , Adulto Jovem
7.
J Pediatr Hematol Oncol ; 44(4): 167-172, 2022 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-34486543

RESUMO

Originally described as mammary analog secretory carcinoma (SC), SC of the salivary gland is a rare malignancy with morphologic and molecular similarities to SC of the breast. We present 2 children with salivary gland SC with the classic ETV6-NTRK3 gene fusion, including 1 with lymph node metastases. Both patients underwent surgical resection and were in remission 24 months postsurgery. One patient was additionally found to have synchronous papillary thyroid carcinoma with a TFG-MET fusion. A review of published cases highlights the expanding molecular profile and confirms the favorable course of salivary gland SC after surgical resection.


Assuntos
Carcinoma , Carcinoma Secretor Análogo ao Mamário , Neoplasias das Glândulas Salivares , Neoplasias da Glândula Tireoide , Biomarcadores Tumorais/genética , Neoplasias da Mama , Carcinoma/genética , Criança , Humanos , Carcinoma Secretor Análogo ao Mamário/genética , Carcinoma Secretor Análogo ao Mamário/patologia , Carcinoma Secretor Análogo ao Mamário/terapia , Proteínas de Fusão Oncogênica/genética , Neoplasias das Glândulas Salivares/genética , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares/patologia , Neoplasias da Glândula Tireoide/genética , Neoplasias da Glândula Tireoide/cirurgia
8.
Head Neck Pathol ; 16(2): 567-572, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34255277

RESUMO

Secretory carcinoma (SC) of salivary gland, previously known as mammary analogue secretory carcinoma, is a rare low-grade malignancy harboring a diagnostic ETV6-NTRK3 gene fusion. SC of salivary gland shares histopathological, immunohistochemical and genetic characteristics with SC of the breast. There are several previous cytomorphological characterizations of SC of salivary gland reported in the literature. The most commonly reported patterns are of epithelial clusters with papillary architectural features, or of single dispersed epithelial cells on a background of abundant histiocytes. Tumor cells exhibit vacuolated eosinophilic cytoplasm and round to oval nuclei with regular nuclear contours and inconspicuous or small nucleoli. The cytomorphology of SC may closely mimic that of acinic cell carcinoma or low-grade mucoepidermoid carcinoma. Moreover, when cohesive epithelial clusters do not appear on the smears, it may be very difficult to distinguish dispersed tumor cells from histiocytes. In this article, we review the literature pertaining to SC cytomorphology and we report a fine needle aspiration biopsy case of SC in salivary gland showing well-defined intracytoplasmic hyaline globules, a feature that has not been previously reported. This novel cytomorphological feature may be helpful in distinguishing the tumor cells of SC from histiocytes and from other low-grade salivary gland tumors.


Assuntos
Carcinoma , Carcinoma Secretor Análogo ao Mamário , Neoplasias das Glândulas Salivares , Biomarcadores Tumorais , Biópsia por Agulha Fina , Neoplasias da Mama , Carcinoma/patologia , Humanos , Carcinoma Secretor Análogo ao Mamário/diagnóstico , Carcinoma Secretor Análogo ao Mamário/genética , Proteínas de Fusão Oncogênica/genética , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares/patologia
9.
J Oral Maxillofac Surg ; 80(1): 101-112, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34653372

RESUMO

PURPOSE: Secretory carcinoma (SC) of the salivary gland, formerly known as mammary analogue secretory carcinoma, is an uncommon and fairly newly described low grade malignant neoplasm of the salivary gland. Given the small number of cases reported in the literature to date, treatment guidelines are scarce. This study aimed to describe the clinical characteristics of SC, discuss prior management strategies, and provide recommendations for future treatment. METHODS: We performed a systematic review of all the cases of SC reported in the literature since it was first recognized in 2010. Using Pubmed, Crossref, and Google Scholar, we identified all articles reporting cases of SC. RESULTS: We identified 657 cases of SC in 109 articles. In addition, we provided 2 new cases, for a total of 659 cases in 110 articles. To our knowledge, this is the largest review of cases of SC in the literature to date. We summarized the clinical characteristics of SC, as well as the nodal status, clinical management, recurrence rate, and death rate. CONCLUSIONS: SC occurs on average in middle age (with a large age range), presents most often initially as localized disease without metastasis, and has a low but not insignificant recurrence rate. Deaths have been reported. The generalized recommendations for treatment of SC are in line with those of other low-grade salivary gland malignancies.


Assuntos
Neoplasias da Mama , Carcinoma , Carcinoma Secretor Análogo ao Mamário , Neoplasias das Glândulas Salivares , Feminino , Humanos , Pessoa de Meia-Idade , Glândulas Salivares
10.
Oral Dis ; 28(7): 1861-1870, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34773340

RESUMO

OBJECTIVE: The present study aimed to characterize and differentiate the ultrasonography (US) and computed tomography (CT) features of mammary analogue secretory carcinoma (MASC) and acinic cell carcinoma (AciCC). METHODS AND PATIENTS: A total of 83 patients with clinically proven MASC and AciCC were analyzed. The following characteristics were assessed on US, CT, and magnetic resonance imaging: lesion size, shape, margin, echogenicity, echotexture, cystic components, posterior echo, vascularity, density, degree of enhancement, enhancement pattern, signal intensity (SI) on T1- and T2-weighted images (WI), hemorrhages, and lymph node enlargement. RESULTS: Similarities were observed between the imaging performance of MASC and AciCC. Differences between the two characteristics of shape on US and cystic components on CT were statistically significant. The proportion of MASC to regular shape on US (p = 0.006) and cystic components on CT (p = 0.027) was significantly higher than that of AciCC. Regular shape on US had the highest sensitivity in the identification of MASC and AciCC, while regular shape on US + cystic component on CT had the highest specificity. CONCLUSIONS: The shape on US and cystic components on CT are key characteristics for distinguishing MASC and AciCC.


Assuntos
Carcinoma de Células Acinares , Carcinoma Secretor Análogo ao Mamário , Neoplasias das Glândulas Salivares , Biomarcadores Tumorais , Carcinoma de Células Acinares/diagnóstico por imagem , Carcinoma de Células Acinares/patologia , Diagnóstico Diferencial , Humanos , Carcinoma Secretor Análogo ao Mamário/diagnóstico por imagem , Carcinoma Secretor Análogo ao Mamário/patologia , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares/patologia , Tomografia Computadorizada por Raios X
11.
Head Neck ; 44(3): 792-804, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-34964195

RESUMO

Mammary analogue secretory carcinomas (MASCs) of the parotid gland are considered as low-grade malignancies with good clinical outcome but lacking data regarding prognostic factors. We performed meta-analysis assessing prognostic factors for disease-free survival (DFS) and overall survival (OS) in 256 patients with MASCs of the parotid gland. A total of 73 studies have met the inclusion criteria and 76.3% of patients were seen with T1 and T2 tumors and negative neck nodes. Lymph node metastasis (57.4%) and distant recurrences (46.2%) were particularly found in T4 tumors (p < 0.001). DFS at 5 and 10 years was 77.9% and 47.2% compared to 88.1% and 77.2% for OS at the same time points. Male sex, T3-T4 tumors, and recurrent disease represented independent worse prognosticators for survival outcome. Altogether, parotid gland MASCs show good long-term outcome, but T4 tumors behave significantly more aggressive and require extended treatment strategies along with close follow-ups.


Assuntos
Carcinoma Secretor Análogo ao Mamário , Neoplasias Parotídeas , Humanos , Masculino , Carcinoma Secretor Análogo ao Mamário/patologia , Estadiamento de Neoplasias , Glândula Parótida/patologia , Glândula Parótida/cirurgia , Neoplasias Parotídeas/patologia , Prognóstico , Estudos Retrospectivos
12.
Ann Diagn Pathol ; 57: 151862, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34953444

RESUMO

Mammary Analogue Secretory Carcinoma (MASC) is a recently described salivary gland tumor frequently sampled via fine-needle aspiration. The cytologic features of MASC are not entirely distinctive and can simulate acinic cell carcinoma, but the tumor harbors an ETV6 gene rearrangement resulting in an ETV6-NTRK3 fusion gene. We present a case of MASC arising in a 31 year old man with a history of multiple radio-embolization procedures.


Assuntos
Carcinoma Secretor Análogo ao Mamário , Exposição à Radiação , Neoplasias das Glândulas Salivares , Adulto , Biomarcadores Tumorais/genética , Humanos , Masculino , Carcinoma Secretor Análogo ao Mamário/genética , Carcinoma Secretor Análogo ao Mamário/patologia , Proteínas de Fusão Oncogênica/genética , Neoplasias das Glândulas Salivares/genética , Neoplasias das Glândulas Salivares/patologia
13.
Einstein (Säo Paulo) ; 20: eRC5724, 2022. graf
Artigo em Inglês | LILACS | ID: biblio-1360392

RESUMO

ABSTRACT Mammary analogue secretory carcinoma is a rare neoplasm usually confused with other neoplasms in the salivary glands region. It has great similarity with the breast carcinoma. We report a case of a patient who presented with gingival submucosal bleeding and lesion, with the initial histopathological examination revealing salivary gland neoplasm of low crane. Computed tomography revealed the lesion near the tooth 27, with extension to the floor of the left maxillary sinus and to the palate mucosa. Resection of the infra-structure was performed, with a diagnosis of breast cancer secretory carcinoma in the minor salivary gland.


Assuntos
Humanos , Neoplasias das Glândulas Salivares/cirurgia , Neoplasias das Glândulas Salivares/diagnóstico por imagem , Carcinoma/cirurgia , Carcinoma/diagnóstico por imagem , Carcinoma Secretor Análogo ao Mamário/diagnóstico por imagem , Glândulas Salivares , Glândulas Salivares Menores/diagnóstico por imagem
14.
Medicine (Baltimore) ; 100(51): e28390, 2021 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-34941172

RESUMO

INTRODUCTION: Secretory carcinoma (SC) is a malignancy of the salivary glands, which is similar to SC of the breast regarding its association with neurotrophic tyrosine receptor kinase fusion-positive gene. SC is a recently described salivary gland tumor, and there are a few reports describing oral minor salivary gland-derived SC. We reported two cases of SC in the oral cavity and reviewed the literature. PATIENT CONCERNS: The patients included a 65-year-old Japanese woman who presented with a mass of the upper lip and an 84-year-old Japanese man who presented with a mass on the buccal mucosa. DIAGNOSIS: Diagnosis was based on histomorphological and immunohistochemical findings and identification of a specific translocation of the ETS variant 6-neurotrophic receptor tyrosine kinase 3 gene fusion. Case 1 was finally diagnosed using reverse transcription-polymerase chain reaction with formalin-fixed paraffin-embedded tissue samples, while case 2 was diagnosed using fluorescence in situ hybridization analysis. INTERVENTIONS AND OUTCOMES: In case 1, excisional biopsy was done and there was no recurrence observed in five-year follow-up. In case 2, tumor resection was done and there was no recurrence observed in two-year follow-up. CONCLUSION: It is highly likely for many cases of SC to be initially diagnosed as acinic cell carcinoma (AciCC) owing to their similar histological findings. The treatment strategy for minor salivary gland-originated SC is similar to that of AciCC; however, SC is often highly malignant and involves a high risk of cervical lymph node metastasis. Thus, establishing an accurate diagnosis together with pathologists and confirming the presence of the ETS variant 6-neurotrophic receptor tyrosine kinase 3 fusion gene using genetic analysis is important.


Assuntos
Proteínas de Fusão Oncogênica/genética , Neoplasias das Glândulas Salivares/diagnóstico , Glândulas Salivares Menores , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/metabolismo , Neoplasias da Mama , Carcinoma/genética , Carcinoma/patologia , Feminino , Humanos , Imuno-Histoquímica , Hibridização in Situ Fluorescente , Imageamento por Ressonância Magnética , Masculino , Carcinoma Secretor Análogo ao Mamário , Proteínas de Fusão Oncogênica/metabolismo , Proteínas Tirosina Quinases , Neoplasias das Glândulas Salivares/genética , Neoplasias das Glândulas Salivares/cirurgia , Glândulas Salivares/cirurgia , Glândulas Salivares Menores/diagnóstico por imagem , Glândulas Salivares Menores/patologia , Resultado do Tratamento
15.
Indian J Pathol Microbiol ; 64(4): 783-787, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34673604

RESUMO

Mammary analog secretory carcinoma (MASC) of salivary gland is a recently described entity. Due to its rarity and cytomorphological overlap with other salivary gland tumors, it is often difficult to recognize on cytology. Here we describe three such cases with their histopathological correlation. All the three tumors arose in the parotid gland. They were misdiagnosed as mucoepidermoid carcinoma, acinic cell carcinoma and salivary duct adenocarcinoma, respectively. Final diagnosis of MASC was established on their follow-up histopathology and immunochemistry evaluation. Cytosmears of these tumors showed high cellularity with papillary architecture lying within fluid background rich in foamy macrophages. Nuclear atypia varied from minimal to marked with frequent mitosis and presence of necrosis. Cytoplasmic vacuolation was a consistent finding. Although the cytomorphological features of MASC are not specific, a diagnosis of MASC should be strongly considered in the presence of papillary architecture, prominent cytoplasmic vacuolations of the tumor cells and a background of cyst fluid. Immunohistochemistry on cell block may be done to confirm the diagnosis.


Assuntos
Carcinoma Secretor Análogo ao Mamário/patologia , Glândula Parótida/patologia , Neoplasias Parotídeas/patologia , Adolescente , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Carcinoma Secretor Análogo ao Mamário/diagnóstico , Glândula Parótida/citologia , Neoplasias Parotídeas/diagnóstico
16.
Neuroradiology ; 63(11): 1901-1911, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34427706

RESUMO

PURPOSE: This retrospective study aimed to investigate the radiological features of head and neck mammary analogue secretory carcinoma (MASC) and systematically review previous publications and 11 new cases. METHODS: We included patients with pathologically proven MASCs with preoperative CT or MRI images, including 11 patients from our hospital and 29 patients from 28 publications extracted after screening 645 abstracts. Two board-certified radiologists reviewed and evaluated all radiological images. The frequency of metastasis during the follow-up period in tumors with well- and ill-defined margins was compared using a Fisher's exact test. RESULTS: The median age at diagnosis was 52.5 years (range, 7-78 years; 20 males). Of the 40 patients, those in their 50 s were the most common (10/40, 25.0%), and the main tumor site was the parotid gland (27/40, 42.5%). Characteristic radiological features included high intensity on T1WI in the cystic components and tumors frequently showed "papillary and cystic," which showed a projection into the cystic components, or "non-papillary and cystic" morphology, which did not show projection of the solid components. Tumor metastasis was found in 10/35 patients (28.6%) during the follow-up period, with a significant difference in frequency between the tumors with well- and ill-defined margin (well-defined (4/26) vs. ill-defined (6/9); P = 0.0074). CONCLUSION: MASCs are newly recognized malignant tumors. Characteristic T1WI high intensity on MRI and predominant cystic morphology may reflect its unique histological profile. Ill-defined tumor margin status was related to frequent metastasis. Awareness of these characteristic radiological features can assist radiologists in better detection of this novel entity.


Assuntos
Carcinoma Secretor Análogo ao Mamário , Neoplasias das Glândulas Salivares , Biomarcadores Tumorais , Humanos , Masculino , Radiografia , Estudos Retrospectivos
17.
J Natl Compr Canc Netw ; 19(5): 478-482, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-34030125

RESUMO

NTRK gene fusions are found in <1% of all cancers but are uniformly present in mammary analog secretory carcinomas (MASC) of the salivary glands. Two selective histology-agnostic tropomyosin receptor kinase (TRK) inhibitors are currently approved for malignancies with these oncogenic fusions. Resistance to TRK inhibition has been recognized, and the mediating mechanisms are presently being studied. This report describes a patient diagnosed with an MASC of the parotid gland who after undergoing multiple lines of treatment was found to have an ETV6-NTRK3 fusion and initiated TRK-targeted therapy using entrectinib. Upon disease progression, we performed tumor genetic sequencing that showed a secondary resistance mutation. The patient subsequently responded to selitrectinib, a next-generation TRK inhibitor.


Assuntos
Compostos Aza/uso terapêutico , Carcinoma Secretor Análogo ao Mamário , Neoplasias das Glândulas Salivares/tratamento farmacológico , Benzamidas , Resistencia a Medicamentos Antineoplásicos , Humanos , Indazóis , Carcinoma Secretor Análogo ao Mamário/tratamento farmacológico , Carcinoma Secretor Análogo ao Mamário/genética , Proteínas de Fusão Oncogênica/genética , Glândula Parótida/patologia , Inibidores de Proteínas Quinases/uso terapêutico , Neoplasias das Glândulas Salivares/genética
18.
J Cutan Pathol ; 48(8): 1069-1074, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-33882152

RESUMO

Secretory carcinoma of the skin is an extremely rare adnexal tumor, histopathologically identical to homologous lesions in the salivary glands and breast tissue. Although this tumor was previously reported as indolent, we report a case of secretory carcinoma of the skin with metastases and recurrence. The patient, a 31-year-old women, had a subcutaneous mass in the right axilla. The resected specimen contained a circumscribed mass, with proliferating tumor cells that exhibited prominent nucleoli. They exhibited glandular and papillary growth patterns and there were amphophilic secretions in the glands. Immunohistochemically, the tumor cells were positive for mammaglobin and S100. The tumor was surrounded by sweat glands and there was no mammary glandular tissue, suggesting that it was derived from axillary sweat glands. Accordingly, we made a diagnosis of secretory carcinoma of the skin. Four years after the operation, there were metastases in both lungs. The resected specimen revealed a tumor identical to that of the original skin tumor. Next-generation sequencing-based multiplex gene assay performed on the metastatic tissue revealed an ETV6-NTRK3 fusion gene. This is a rare case report of secretory carcinoma of the skin with lymph node metastases and recurrence in both lungs.


Assuntos
Neoplasias Pulmonares/secundário , Metástase Linfática/patologia , Carcinoma Secretor Análogo ao Mamário/diagnóstico , Neoplasias Cutâneas/patologia , Glândulas Sudoríparas/patologia , Adulto , Diagnóstico Diferencial , Feminino , Sequenciamento de Nucleotídeos em Larga Escala/métodos , Humanos , Imuno-Histoquímica/métodos , Neoplasias Pulmonares/cirurgia , Metástase Linfática/radioterapia , Carcinoma Secretor Análogo ao Mamário/metabolismo , Carcinoma Secretor Análogo ao Mamário/secundário , Carcinoma Secretor Análogo ao Mamário/cirurgia , Recidiva Local de Neoplasia , Proteínas de Fusão Oncogênica/genética , Proteínas S100/metabolismo , Secretoglobinas/metabolismo , Glândulas Sudoríparas/metabolismo , Cirurgia Torácica Vídeoassistida/métodos
19.
Head Neck Pathol ; 15(3): 893-904, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33660147

RESUMO

Secretory carcinoma (SC) is an uncommon salivary gland neoplasm of the oral cavity that microscopically may mimic acinic cell carcinoma (ACC) and mucoepidermoid carcinoma (MEC). This study describes a series of SC in minor glands with a literature review. We performed a retrospective search for oral SC, within the archives of the University of Florida, Oral Pathology and Surgical Pathology Biopsy services from 2010 to 2018. A total of 10 SCs were identified in the oral and maxillofacial region, four of which were in the minor salivary glands. The demographic, clinical, histological, and molecular findings were aggregated for all 4 cases. Patient age varied from 30 to 60 years, with an average of 45 years. Two cases each were in female and male patients. Two cases presented on the labial mucosa, and one each on the hard and soft palate. Immunohistochemical (IHC) staining showed mammaglobin positivity in all cases, GATA3 positivity in two cases, S100 positivity in three cases, and SOX10 positivity in only one case. Fluorescence in situ hybridization demonstrated positivity for ETV6-NTRK3 fusion in 4 cases. Although oral SC is rare, pathologists should be aware of the histologic overlap between the SC and other salivary gland neoplasms such as ACC and MEC. A judicious application of IHC staining would aid in diagnosis. SC should be considered in the differential diagnosis for intraoral salivary gland tumors.


Assuntos
Carcinoma Secretor Análogo ao Mamário/patologia , Neoplasias das Glândulas Salivares/patologia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
20.
Med Mol Morphol ; 54(3): 296-300, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33452913

RESUMO

Secretory carcinoma of the salivary glands is a relatively new disease concept, and is characterized by "morphological resemblance to mammary secretory carcinoma and ETV6-NTRK3 gene fusion." Herein we describe a confusing case and briefly discuss practical diagnostic problems. The patient was a 71-year-old Japanese man who had a tumor consistent with secretory carcinoma at the microscopic and immunohistochemical levels. Immunohistochemically, EMA and S100 protein were noted to be positive along with various cytokeratins as well as mammaglobin and pSTAT5. Moreover, vimentin was focally positive. Smooth muscle actin, p63, p40, and androgen receptor were negative. However, a search using fluorescence in situ hybridization did not reveal a definite split signal for the ETV6 gene. It is presumed that confirming the diagnosis of secretory carcinoma without genetic retrieval will be accepted as a diagnostic method, and we hope that worldwide general recognition may earlier reach "gradual acceptance."


Assuntos
Biomarcadores Tumorais/análise , Carcinoma Secretor Análogo ao Mamário/diagnóstico , Neoplasias Parotídeas/diagnóstico , Proteínas Proto-Oncogênicas c-ets/análise , Proteínas Repressoras/análise , Idoso , Regulação Neoplásica da Expressão Gênica , Humanos , Imuno-Histoquímica , Queratinas/análise , Queratinas/genética , Masculino , Carcinoma Secretor Análogo ao Mamário/metabolismo , Carcinoma Secretor Análogo ao Mamário/patologia , Neoplasias Parotídeas/metabolismo , Neoplasias Parotídeas/patologia , Proteínas S100/análise , Proteínas S100/genética , Fator de Transcrição STAT5/análise , Fator de Transcrição STAT5/genética
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