Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 151
Filtrar
1.
Phys Sportsmed ; 49(1): 116-122, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-32404042

RESUMO

Case presentation: A 32-year-old professional bodybuilder presented with acute decompensated heart failure. He gave a history of anabolic androgenic steroids (AAS) use for >2 years and mephentermine use for the preceding 3 months. Management: Transthoracic echocardiography showed severe left ventricular (LV) dysfunction with a large pedunculated, mobile thrombus attached to the ventricular apex. The patient had an embolic stroke during the hospital stay, with complete neurological recovery. Following the cessation of mephentermine use, there was a steady improvement in LV function over a follow-up of 2 months. However, at 3 months, his ventricular function showed deterioration, which coincided with mephentermine reuse. Take home message: Though AAS abuse by athletes leading to such a presentation has been documented, to the best of our knowledge, a similar role of mephentermine has not been reported.


Assuntos
AVC Embólico/induzido quimicamente , Mefentermina/efeitos adversos , Substâncias para Melhoria do Desempenho/efeitos adversos , Congêneres da Testosterona/efeitos adversos , Disfunção Ventricular Esquerda/induzido quimicamente , Levantamento de Peso , Adulto , Cardiomiopatias , Ecocardiografia , AVC Embólico/diagnóstico por imagem , Humanos , Masculino , Recidiva , Disfunção Ventricular Esquerda/diagnóstico por imagem
2.
BMJ Case Rep ; 13(11)2020 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-33139366

RESUMO

Mephentermine is a vasopressor drug closely related to amphetamine and methamphetamine. Cases of abuse and dependence to mephentermine have dotted medical literature for a long time. Till date, 11 cases of dependence to mephentermine have been published. In this report, a case of mephentermine dependence is being discussed. The patient was a young adult male who was dependent to mephentermine for nearly 3 years. He was an athlete and was introduced to mephentermine by his peer for enhancing performance. He did not develop any major physical or psychiatric issue due to the drug. He was managed on out patient basis. Though cases of mephentermine dependence are few and far in medical literature, reports from other sources indicate that the problem could be more common and could be on rise. High index of suspicion and holistic care is likely to help patients and treating clinicians.


Assuntos
Gerenciamento Clínico , Mefentermina/efeitos adversos , Transtornos Relacionados ao Uso de Substâncias/etiologia , Adulto , Humanos , Índia , Masculino , Transtornos Psicóticos , Transtornos Relacionados ao Uso de Substâncias/diagnóstico , Transtornos Relacionados ao Uso de Substâncias/terapia , Vasoconstritores/efeitos adversos
3.
J Vet Pharmacol Ther ; 41(2): 274-280, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28804906

RESUMO

The goal of this study was to confirm the vasopressor and cardiac effects of POTENAY® INJETÁVEL (POT), a mephentermine-based product, given to cattle with induced vascular/cardiac depression. Ten healthy Holstein cattle (206 ± 13 kg) followed a randomized-complete-block design (RCBD) utilizing crossover study design. Each animal randomly received (1 ml/25 kg, IM) of either POT (n = 10) or volume-matched placebo control (0.9%NaCl, CP, n = 10). A subset of animals (n = 5) received POT first (day 0) while the remaining (n = 5) received CP; after a six-day washout period, cattle received the opposite compound. Animals were anesthetized and catheterized for systemic/left ventricular hemodynamic monitoring. Myocardial dysfunction/hypotension was induced by increasing the end-tidal isoflurane concentration until arterial blood pressure was 20% lower than at baseline and remained stable. Once the animal was determined to be hypotensive and hemodynamically stable, steady-state hypotensive baseline data (BL2) were acquired, and treatment with either POT or CP was given. Data were acquired post-treatment at every 15 min for 90 min. POT improved cardiac output (+68 L/min, ±14%, p < 0.05), MAP (+14 mmHg, ±4%, p < 0.05), HR (+22 bpm, ±8%, p < 0.05), and peak rates of ventricular pressure change during both systole (dP/dtmax : +37 mmHg/s ±13%, p < 0.05) and diastole (dP/dtmin : +31 mmHg/s, ±7%, p < 0.05). No improvements were noted following placebo-control administration. Results indicate that POT improves cardiac performance and systemic hemodynamics in cattle with induced cardiovascular depression when given as single intramuscular injection.


Assuntos
Cardiotônicos/farmacologia , Doenças dos Bovinos/tratamento farmacológico , Cardiopatias/veterinária , Coração/efeitos dos fármacos , Mefentermina/farmacologia , Vasoconstritores/farmacologia , Animais , Pressão Sanguínea/efeitos dos fármacos , Débito Cardíaco/efeitos dos fármacos , Cardiotônicos/administração & dosagem , Bovinos , Estudos Cross-Over , Feminino , Cardiopatias/tratamento farmacológico , Injeções Intramusculares/veterinária , Masculino , Mefentermina/administração & dosagem , Vasoconstritores/administração & dosagem
5.
J Chromatogr B Analyt Technol Biomed Life Sci ; 1029-1030: 22-27, 2016 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-27398632

RESUMO

Nonmedical use of prescription stimulants such as phentermine (PT) has been regulated by law enforcement authorities due to its euphorigenic and relaxing effects. Due to high potential for its abuse, reliable analytical methods were required to detect and identify PT and its metabolite in biological samples. Thus a dilute and shoot liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for simultaneous determination of PT, N-hydroxyphentermine (NHOPT) and mephentermine (MPT) in urine. A 5µL aliquot of diluted urine was injected into the LC-MS/MS system. Chromatographic separation was performed by reversed-phase C18 column with gradient elution for all analytes within 5min. Identification and quantification were based on multiple reaction monitoring (MRM) detection. Linear least-squares regression with a 1/x(2) weighting factor was used to generate a calibration curve and the assay was linear from 50 to 15000ng/mL (PT and MPT) and 5 to 750ng/mL (NHOPT). The intra- and inter-day precisions were within 8.9% while the intra- and inter-day accuracies ranged from -6.2% to 11.2%. The limits of quantification were 3.5ng/mL (PT), 1.5ng/mL (NHOPT) and 1.0ng/mL (MPT). Method validation requirements for selectivity, dilution integrity, matrix effect and stability were satisfied. The applicability of the developed method was examined by analyzing urine samples from drug abusers.


Assuntos
Estimulantes do Sistema Nervoso Central/urina , Cromatografia Líquida de Alta Pressão/métodos , Mefentermina/urina , Fentermina/análogos & derivados , Fentermina/urina , Detecção do Abuso de Substâncias/métodos , Simpatomiméticos/urina , Humanos , Limite de Detecção , Espectrometria de Massas em Tandem/métodos
9.
Gen Hosp Psychiatry ; 35(6): 681.e9-10, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23759255

RESUMO

Mephentermine misuse or dependence has been rarely reported in the literature. This is surprising as mephentermine bears a close structural similarity to methamphetamine. Here we report a case of mephentermine dependence with induced psychosis. A 23-year-old professional weightlifter used to administer mephentermine (60 mg) for improving performance in tournaments. The patient became dependent on mephentermine in 2009, and his consumption increased to 100-150 mg every 2-3 days since August 2012 until his presentation in clinic in mid-October 2012. He developed psychosis and had persecutory delusions. Remission of psychosis was seen with stopping use of mephentermine and use of antipsychotic medication.


Assuntos
Transtornos Relacionados ao Uso de Anfetaminas/complicações , Delusões/induzido quimicamente , Mefentermina/envenenamento , Psicoses Induzidas por Substâncias/etiologia , Simpatomiméticos/envenenamento , Humanos , Masculino , Adulto Jovem
13.
Anaesthesia ; 65(12): 1200-5, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21182601

RESUMO

This study compared the effects of intravenous infusions of phenylephrine and mephentermine on the prevention of maternal hypotension and neonatal outcome in patients receiving spinal anaesthesia for caesarean section. Sixty ASA 1-2 patients with term, uncomplicated singleton pregnancy undergoing caesarean section under spinal anaesthesia were randomly divided into two groups of 30 each, to receive a prophylactic intravenous infusion of either phenylephrine or mephentermine. The incidence of hypotension was statistically similar in the two groups. However, in patients receiving phenylephrine, 7 (23%) developed bradycardia and 6 (20%), reactive hypertension. Neonatal outcome, in terms of Apgar scores and umbilical artery pH, was similar in both the groups. To conclude, phenylephrine and mephentermine infusions are equally effective in preventing post spinal hypotension in patients undergoing caesarean section and are associated with a similar neonatal outcome.


Assuntos
Anestesia Obstétrica/efeitos adversos , Raquianestesia/efeitos adversos , Hipotensão/prevenção & controle , Mefentermina/uso terapêutico , Fenilefrina/uso terapêutico , Vasoconstritores/uso terapêutico , Agonistas de Receptores Adrenérgicos alfa 1/uso terapêutico , Adulto , Pressão Sanguínea/efeitos dos fármacos , Cesárea , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Hipotensão/etiologia , Hipotensão/fisiopatologia , Recém-Nascido , Gravidez , Resultado da Gravidez , Adulto Jovem
14.
JNMA J Nepal Med Assoc ; 49(177): 23-8, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-21180216

RESUMO

INTRODUCTION: Hypotension is common following spinal anesthesia. Various vasopressors have been indicated to prevent it. The study compares three such agents namely phenylephrine, ephedrine and mephentermine. METHODS: The study included 90 patients undergoing elective and emergency cesarean section who developed hypotension following subarachnoid blockade. Parturient were randomly divided into three groups each group had 30 patients. Group P received bolus of Phenylephrine 25 microgram, where as group E received Ephedrine 5mg and Group M received Mephentermine 6mg. RESULTS: It was found that rise of blood pressure was significantly higher in case of phenylephrine group in first six minutes, after the bolus, there was significant reduction in the heart rate in phenylephrine group, but there was tachycardia following administration of bolus ephedrine and mephenteramine. Neonatal APGAR score were similar in all three groups. CONCLUSIONS: All three drugs maintained hemodynamics within 20 percent of the baseline values on intravenous administration.


Assuntos
Cesárea , Efedrina/farmacocinética , Mefentermina/farmacologia , Fenilefrina/farmacologia , Simpatomiméticos/farmacologia , Vasoconstritores/farmacologia , Adulto , Raquianestesia , Pressão Sanguínea/efeitos dos fármacos , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Hipotensão/prevenção & controle , Fenilefrina/administração & dosagem , Complicações Pós-Operatórias/prevenção & controle , Gravidez , Adulto Jovem
15.
Addiction ; 105(6): 1129-30, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20456293

RESUMO

BACKGROUND: Substance abuse is a serious health concern. This report presents the case of a 22-year-old Brazilian man with a history of mephentermine use who fulfils all the criteria for chemical dependence listed by ICD-10. Mephentermine is a sympathomimetic agent derived from methamphetamine which, in Brazil, is restricted to veterinary use. CASE DESCRIPTION: The subject used the substance at a high dose (120 mg) to improve his physical performance while working out at a gym. His symptoms included anorexia and insomnia. After days of intense activity, he felt fatigue and soreness. A physical examination revealed scars on both forearms from the injections and a psychological examination revealed moderate speech and motor agitation. CONCLUSIONS: Cases such as this may be common among the general public. They should have some bearing upon medical practice and public health policies involving drugs.


Assuntos
Transtornos Relacionados ao Uso de Anfetaminas/complicações , Mefentermina/efeitos adversos , Agitação Psicomotora/etiologia , Simpatomiméticos/efeitos adversos , Adulto , Animais , Anorexia/induzido quimicamente , Brasil , Depressão/induzido quimicamente , Fadiga/induzido quimicamente , Política de Saúde , Humanos , Masculino , Mefentermina/farmacologia , Distúrbios do Início e da Manutenção do Sono/induzido quimicamente , Simpatomiméticos/farmacologia , Adulto Jovem
17.
J AOAC Int ; 93(1): 116-22, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20334173

RESUMO

A GC method was developed for the identification and quantitation of eight sympathomimetic amines in urine, i.e., amphetamine, methamphetamine, mephentermine, ephedrine, pseudoephedrine, methylenedioxyamphetamine, methylenedioxymethamphetamine, and methylenedioxyethylamphetamine. Methoxyphenamine was used as the internal standard (IS). The assay is rapid, sensitive, and simple to perform. It involves a liquid-liquid extraction procedure with simultaneous in-solution derivatization of the organic layer with pentafluorobenzoyl chloride (PFB-CI), followed by GC/MS analysis. These derivatives and the IS were extracted from 1 mL alkaline urine into hexane before derivatization with PFB-CI. The organic layer was then removed and evaporated to dryness before dissolution with hexane for GC/MS analysis. Calibration curves for each analyte showed linearity in the range of 25-5000 ng/mL (r2 > or = 0.997). Recoveries ranged from 88 to 99%, with the precision of recoveries typically < or = 5%. The LOD values ranged from 7 to 28 ng/mL, and the LOQ values ranged from 23 to 94 ng/mL. At least four ions were available for each analyte for confirmation of identity by MS.


Assuntos
Cromatografia Gasosa-Espectrometria de Massas/métodos , Simpatomiméticos/urina , 3,4-Metilenodioxianfetamina/análogos & derivados , 3,4-Metilenodioxianfetamina/urina , Anfetamina/urina , Efedrina/urina , Cromatografia Gasosa-Espectrometria de Massas/normas , Cromatografia Gasosa-Espectrometria de Massas/estatística & dados numéricos , Humanos , Mefentermina/urina , Metanfetamina/urina , Estrutura Molecular , N-Metil-3,4-Metilenodioxianfetamina/urina , Pseudoefedrina/urina , Padrões de Referência , Simpatomiméticos/química , Simpatomiméticos/normas
18.
J Anal Toxicol ; 34(2): 73-7, 2010 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-20223098

RESUMO

Mephentermine and phentermine, substances prohibited in sports by the World Anti-Doping Agency, were found for the first time in urine specimens following the administration of a therapeutic medication, oxethazaine. In a recent sporting event, a urine specimen donor who tested positive for mephentermine and phentermine claimed consumption of Mucaine((R)) for treating stomach pain was the reason for testing positive. Five volunteers were administrated oxethazaine (a topical anesthetic found in the multi-ingredient medication Mucaine and its generic equivalent, Stoin, both of which are available in Taiwan), mephentermine, and phentermine. Excretion profiles of mephentermine and phentermine following the administration of these drugs were found to be similar. However, the mephentermine/phentermine ratios found in urine specimens collected at different time points following the administration of oxethazine and mephentermine were found to be characteristically different.


Assuntos
Etanolaminas/administração & dosagem , Etanolaminas/metabolismo , Mefentermina/urina , Fentermina/urina , Anidridos Acéticos , Adulto , Anestésicos Locais/administração & dosagem , Anestésicos Locais/química , Anestésicos Locais/metabolismo , Calibragem , Doping nos Esportes , Etanolaminas/química , Feminino , Fluoracetatos , Cromatografia Gasosa-Espectrometria de Massas , Humanos , Masculino , Mefentermina/administração & dosagem , Mefentermina/química , Mefentermina/metabolismo , Fentermina/administração & dosagem , Fentermina/química , Fentermina/metabolismo , Reprodutibilidade dos Testes , Detecção do Abuso de Substâncias , Ácido Trifluoracético/química
19.
Anaesth Intensive Care ; 37(4): 568-70, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19681412

RESUMO

This study was designed to determine the minimum effective dose (ED50) of mephentermine for prevention of post-spinal hypotension in women undergoing elective caesarean section. Dixon's up-down method of sequential allocation was used to determine the patient's dose of vasopressor drug. In our previous study, mephentermine appeared to be much more potent than ephedrine, so the present study was conducted using a lower initial dose and smaller dose interval for this vasopressor. Following administration of spinal anaesthesia, a prophylactic infusion of mephentermine was started with 5 mg infused over a period of 30 minutes as the initial dose and a dose interval of 1 mg. The ED50 of mephentermine of 3.7 mg (95% confidence interval 2.4 to 5.7 mg) was much less than that of ephedrine, as calculated in our previous study using the same methodology. Using these values gives a potency ratio of ephedrine to mephentermine of 1:6.8 (95% confidence interval 6.0 to 7.5).


Assuntos
Anestesia Obstétrica/efeitos adversos , Raquianestesia/efeitos adversos , Hipotensão/tratamento farmacológico , Mefentermina/uso terapêutico , Simpatomiméticos/uso terapêutico , Adulto , Cesárea , Feminino , Humanos , Gravidez
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...