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1.
Behav Brain Res ; 437: 114151, 2023 Feb 02.
Artigo em Inglês | MEDLINE | ID: mdl-36216142

RESUMO

Temporal order memory refers to the ability to remember the order of occurrence of items across time. It is a critical feature of episodic memory that is often tested in rodents using spontaneous object recognition paradigms. However, impact of aging over performances of temporal order memory decline is barely known. Herein, we characterized here the effect of normal aging on the temporal order memory performances in NMRI mice between 3 and 19months of age, with an inter-session interval of 24h.We found that temporal order memory was impaired as soon as7 months of age. These results provide strong evidence that temporal order memory is particularly vulnerable to the deleterious effect of normal aging.


Assuntos
Envelhecimento , Transtornos da Memória , Animais , Camundongos , Envelhecimento/psicologia , Transtornos da Memória/psicologia , Memória Episódica , Camundongos Endogâmicos , Reconhecimento Psicológico
2.
Nat Commun ; 13(1): 6508, 2022 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-36316315

RESUMO

Our memories form a tapestry of events, people, and places, woven across the decades of our lives. However, research has often been limited in assessing the nature of episodic memory by using artificial stimuli and short time scales. The explosion of social media enables new ways to examine the neural representations of naturalistic episodic memories, for features like the memory's age, location, memory strength, and emotions. We recruited 23 users of a video diary app ("1 s Everyday"), who had recorded 9266 daily memory videos spanning up to 7 years. During a 3 T fMRI scan, participants viewed 300 of their memory videos intermixed with 300 from another individual. We find that memory features are tightly interrelated, highlighting the need to test them in conjunction, and discover a multidimensional topography in medial parietal cortex, with subregions sensitive to a memory's age, strength, and the familiarity of the people and places involved.


Assuntos
Memória Episódica , Humanos , Lobo Parietal/diagnóstico por imagem , Mapeamento Encefálico , Reconhecimento Psicológico , Imageamento por Ressonância Magnética , Neuroimagem , Rememoração Mental
3.
Trends Cogn Sci ; 26(12): 1059-1061, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36335016

RESUMO

What are the neural and computational principles that give rise to episodic memory? Although memory is probably the most studied topic in psychology and cognitive neuroscience, most research has focused on learning at the micro-level. I outline the limitations of this approach and propose a 'molar' approach to tackle episodic memory at the scale of life.


Assuntos
Neurociência Cognitiva , Memória Episódica , Humanos
4.
eNeuro ; 9(6)2022.
Artigo em Inglês | MEDLINE | ID: mdl-36376083

RESUMO

Human cognitive abilities decline with increasing chronological age, with decreased explicit memory performance being most strongly affected. However, some older adults show "successful aging," that is, relatively preserved cognitive ability in old age. One explanation for this could be higher brain-structural integrity in these individuals. Alternatively, the brain might recruit existing resources more efficiently or employ compensatory cognitive strategies. Here, we approached this question by testing multiple candidate variables from structural and functional neuroimaging for their ability to predict chronological age and memory performance, respectively. Prediction was performed using support vector machine (SVM) classification and regression across and within two samples of young (N = 106) and older (N = 153) adults. The candidate variables were (1) behavioral response frequencies in an episodic memory test; (2) recently described functional magnetic resonance imaging (fMRI) scores reflecting preservation of functional memory networks; (3) whole-brain fMRI contrasts for novelty processing and subsequent memory; (4) resting-state fMRI maps quantifying voxel-wise signal fluctuation; and (5) gray matter volume estimated from structural MRIs. While age group could be reliably decoded from all variables, chronological age within young and older subjects was best predicted from gray matter volume. In contrast, memory performance was best predicted from task-based fMRI contrasts and particularly single-value fMRI scores, whereas gray matter volume has no predictive power with respect to memory performance in healthy adults. Our results suggest that superior memory performance in healthy older adults is better explained by efficient recruitment of memory networks rather than by preserved brain structure.


Assuntos
Imageamento por Ressonância Magnética , Memória Episódica , Humanos , Idoso , Cognição/fisiologia , Encéfalo/fisiologia , Mapeamento Encefálico , Envelhecimento/fisiologia
5.
Artigo em Inglês | MEDLINE | ID: mdl-36361266

RESUMO

Previous research has revealed some mechanisms underlying the generalization of reward expectation of generalization stimuli, but little is known about the generalization of episodic memory for rewarding events, its consolidation, and how reward components such as expected value and reward uncertainty affect it. Participants underwent a Pavlovian reward-conditioning task to test whether reward conditioning would enhance episodic memory generalization and which reward components would directly affect it. Counterbalanced across participants, one semantic category was paired with a reward, while the other was never paired. Following a delay of either 5 min or 24 h, participants took a memory test consisting of old, highly similar, and new items. We found that participants were more likely to falsely recognize lure items as old in the reward-paired category after 5 min and 24 h delays. These results indicate that reward conditioning enhanced the generalization of episodic memory, but this effect was not necessarily dependent on consolidation. The composite score and raw data of generalization further showed that the uncertainty and expected value enhanced generalization. Together, these findings revealed an effect of reward conditioning on episodic memory generalization and supported the enhancement effects of expected value and uncertainty.


Assuntos
Memória Episódica , Humanos , Incerteza , Recompensa , Condicionamento Clássico , Semântica
6.
Cell Rep ; 41(7): 111643, 2022 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-36384113

RESUMO

Episodic memories formed in early childhood rapidly decay, but their latent traces remain stored long term. These memories require the dorsal hippocampus (dHPC) and seem to undergo a developmental critical period. It remains to be determined whether the maturation of parvalbumin interneurons (PVIs), a major mechanism of critical periods, contributes to memory development. Here, we show that episodic infantile learning significantly increases the levels of parvalbumin in the dHPC 48 h after training. Chemogenetic inhibition of PVIs before learning indicated that these neurons are required for infantile memory formation. A bilateral dHPC injection of the γ-aminobutyric acid type A receptor agonist diazepam after training elicited long-term memory expression in infant rats, although direct PVI chemogenetic activation had no effect. Finally, PVI activity was required for brain-derived neurotrophic factor (BDNF)-dependent maturation of memory competence, i.e., adult-like long-term memory expression. Thus, dHPC PVIs are critical for the formation of infantile memories and for memory development.


Assuntos
Memória Episódica , Parvalbuminas , Pré-Escolar , Ratos , Humanos , Animais , Interneurônios/fisiologia , Hipocampo/fisiologia
7.
Proc Natl Acad Sci U S A ; 119(42): e2208681119, 2022 10 18.
Artigo em Inglês | MEDLINE | ID: mdl-36215461

RESUMO

Older adults are frequent targets and victims of financial fraud. They may be especially susceptible to revictimization because of age-related changes in both episodic memory and social motivation. Here we examined these factors in a context where adaptive social decision-making requires intact associative memory for previous social interactions. Older adults made more maladaptive episodic memory-guided social decisions but not only because of poorer associative memory. Older adults were biased toward remembering people as being fair, while young adults were biased toward remembering people as being unfair. Holding memory constant, older adults engaged more with people that were familiar (regardless of the nature of the previous interaction), whereas young adults were prone to avoiding others that they remembered as being unfair. Finally, older adults were more influenced by facial appearances, choosing to interact with social partners that looked more generous, even though those perceptions were inconsistent with prior experience.


Assuntos
Tomada de Decisões , Memória Episódica , Comportamento Social , Idoso , Envelhecimento , Humanos , Transtornos da Memória , Rememoração Mental , Motivação , Adulto Jovem
8.
Proc Natl Acad Sci U S A ; 119(43): e2201540119, 2022 10 25.
Artigo em Inglês | MEDLINE | ID: mdl-36251990

RESUMO

Episodic autobiographical memories are characterized by a spatial context and an affective component. But how do affective and spatial aspects interact? Does affect modulate the way we encode the spatial context of events? We investigated how one element of affect, namely aesthetic liking, modulates memory for location, in three online experiments (n = 124, 79, and 80). Participants visited a professionally curated virtual art exhibition. They then relocated previously viewed artworks on the museum map and reported how much they liked them. Across all experiments, liking an artwork was associated with increased ability to recall the wall on which it was hung. The effect was not explained by viewing time and appeared to modulate recognition speed. The liking-wall memory effect remained when participants attended to abstractness, rather than liking, and when testing occurred 24 h after the museum visit. Liking also modulated memory for the room where a work of art was hung, but this effect primarily involved reduced room memory for disliked artworks. Further, the liking-wall memory effect remained after controlling for effects of room memory. Recalling the wall requires recalling one's facing direction, so our findings suggest that positive aesthetic experiences enhance first-person spatial representations. More generally, a first-person component of positive affect transfers to wider spatial representation and facilitates the encoding of locations in a subject-centered reference frame. Affect and spatial representations are therefore important, and linked, elements of sentience and subjectivity. Memories of aesthetic experiences are also spatial memories of how we encountered a work of art. This linkage may have implications for museum design.


Assuntos
Memória Episódica , Emoções , Estética , Humanos , Rememoração Mental , Museus
9.
Neurocase ; 28(4): 410-414, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36260764

RESUMO

A 52-year-old male patient with a background of adaptive personality disorder was admitted for mitral valve repair and cardiac ablation for atrial fibrillation. He suffered intraoperative complications with severe mitral insufficiency that suffered ischemia.. Post-operatively, he demonstrated acute loss of retrograde autobiographical memory, prosopagnosia and a loss of public semantic memory. His CT scan was normal and MRI was not possible due to intra-cardiac leads. An initial diagnosis of hypoxic-ischemic encephalopathy was considered. A neuropsychological examination undertaken 20 days after his surgery showed a severe alteration of retrograde autobiographical memory, marked alteration of semantic knowledge and prosopagnosia. He demonstrated an average performance in tasks measuring constructional praxis, visuospatial ability, and executive functions. 34 days after surgery, and after a short nap, the patient "returns" to the day before admission and consequently recovers his memory. Repeat neuropsychological assessment demonstrated performance within the normal range across all previously tested domains. This sudden recovery of memory, together with a normal MRI, led to a rethinking of the diagnosis of dissociative amnesia. This case illustrates the long-standing discussion about the organic or functional origin of some memory disorders, in which, despite advances in neuroimaging techniques, it is still difficult to know their etiology .


Assuntos
Memória Episódica , Prosopagnosia , Masculino , Humanos , Pessoa de Meia-Idade , Filmes Cinematográficos , Prosopagnosia/complicações , Amnésia/etiologia , Testes Neuropsicológicos , Amnésia Retrógrada/diagnóstico , Amnésia Retrógrada/etiologia
10.
Trends Cogn Sci ; 26(12): 1043-1046, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36207261

RESUMO

How do we remember our past experiences? This question remains stubbornly resistant to resolution. The next 25 years may see significant traction on this and other outstanding issues if memory researchers capitalise on exciting technological developments that allow embodied cognition to be studied in ways that closely approximate real life.


Assuntos
Memória Episódica , Rememoração Mental , Humanos , Cognição
11.
Learn Mem ; 29(11): 412-420, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36253008

RESUMO

Visual imagery and mental reconstruction of scenes are considered core components of episodic memory retrieval. Individuals with absent visual imagery (aphantasia) score lower on tests of autobiographical memory, suggesting that aphantasia may be associated with differences in episodic and associative processing. In this online study, we tested aphantasic participants and controls on associative recognition and memory confidence for three types of associations encoded incidentally: associations between visual-visual and audio-visual stimulus pairs, associations between an object and its location on the screen, and intraitem associations. Aphantasic participants had a lower rate of high-confidence hits in all associative memory tests compared with controls. Performance on auditory-visual associations was correlated with individual differences in a measure of object imagery in the aphantasic group but not in controls. No overall group difference in memory performance was found, indicating that visual imagery selectively contributes to memory confidence. Analysis of the encoding task revealed that aphantasics made fewer associative links between the stimuli, suggesting a role for visual imagery in associative processing of visual and auditory input. These data enhance our understanding of visual imagery contributions to associative memory and further characterize the cognitive profile of aphantasia.


Assuntos
Imaginação , Memória Episódica , Cognição , Humanos , Individualidade , Reconhecimento Psicológico
12.
Proc Natl Acad Sci U S A ; 119(44): e2123417119, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36279428

RESUMO

The last decade has seen significant progress in identifying sleep mechanisms that support cognition. Most of these studies focus on the link between electrophysiological events of the central nervous system during sleep and improvements in different cognitive domains, while the dynamic shifts of the autonomic nervous system across sleep have been largely overlooked. Recent studies, however, have identified significant contributions of autonomic inputs during sleep to cognition. Yet, there remain considerable gaps in understanding how central and autonomic systems work together during sleep to facilitate cognitive improvement. In this article we examine the evidence for the independent and interactive roles of central and autonomic activities during sleep and wake in cognitive processing. We specifically focus on the prefrontal-subcortical structures supporting working memory and mechanisms underlying the formation of hippocampal-dependent episodic memory. Our Slow Oscillation Switch Model identifies separate and competing underlying mechanisms supporting the two memory domains at the synaptic, systems, and behavioral levels. We propose that sleep is a competitive arena in which both memory domains vie for limited resources, experimentally demonstrated when boosting one system leads to a functional trade-off in electrophysiological and behavioral outcomes. As these findings inevitably lead to further questions, we suggest areas of future research to better understand how the brain and body interact to support a wide range of cognitive domains during a single sleep episode.


Assuntos
Memória Episódica , Memória de Curto Prazo , Sono/fisiologia , Encéfalo/fisiologia , Sistema Nervoso Autônomo
13.
Acta Psychol (Amst) ; 230: 103767, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-36252392

RESUMO

Laboratory and clinical studies have shown that odors tend to evoke highly emotional autobiographical memories that frequently come from an early period in life. One potential explanation for this effect is that all memories associated with odors are particularly emotional, while another potential explanation is that the presence of an (emotional) odor during retrieval leads to the participants' impression that the retrieved memory is particularly emotional. To this point, nearly all research on odor evoked autobiographical memories has relied on the presence of an odor to cue the memory, a procedure that does not allow one to distinguish whether the emotionality of the memories is due to the memory itself or the presence of the current cue. In contrast, in the current studies, no stimuli were presented during the retrieval of autobiographical memories. Instead, we asked people to report on memories specifically associated with the five traditional different senses or asked for information about autobiographical memories evoked throughout the day and assessed the role of the senses in those experienced memories. Across the three studies, using slightly different methodologies, we found that odor associated autobiographical memories are not more emotional or older than memories (mainly) associated with other modalities. Our results carefully put into question the notion that odor associated autobiographical memories are more emotional than autobiographical memories mostly associated with other modalities. Since the difference between the presented and previous studies lies in a different situation at AM retrieval, these results present evidence towards retrieval-based explanations.


Assuntos
Memória Episódica , Odorantes , Humanos , Emoções/fisiologia , Sensação , Rememoração Mental , Sinais (Psicologia)
14.
Cell Rep ; 41(1): 111453, 2022 10 04.
Artigo em Inglês | MEDLINE | ID: mdl-36198271

RESUMO

The hippocampus plays a critical role in spatial navigation and episodic memory. However, research on in vivo hippocampal activity dynamics mostly relies on single modalities, such as electrical recordings or optical imaging, with respectively limited spatial and temporal resolution. Here, we develop the E-Cannula, integrating fully transparent graphene microelectrodes with imaging cannula, which enables simultaneous electrical recording and two-photon calcium imaging from the exact same neural populations across an anatomically extended region of the mouse hippocampal CA1 stably across several days. The large-scale multimodal recordings show that sharp wave ripples (SWRs) exhibit spatiotemporal wave patterns along multiple axes in two-dimensional (2D) space with different spatial extents and temporal propagation modes. Notably, distinct SWR wave patterns are associated with the selective recruitment of orthogonal CA1 cell assemblies. These results demonstrate the utility of the E-Cannula as a versatile neurotechnology with the potential for future integration with other optical components.


Assuntos
Grafite , Memória Episódica , Animais , Região CA1 Hipocampal , Cálcio , Cânula , Hipocampo , Camundongos
15.
Philos Trans R Soc Lond B Biol Sci ; 377(1866): 20210337, 2022 12 19.
Artigo em Inglês | MEDLINE | ID: mdl-36314151

RESUMO

Episodic counterfactual thoughts (eCFT) consist of imagining alternative outcomes to past experiences. A common sub-class of eCFT-upward eCFT-involves imagining how past negative experiences could have been better, either because one could have done something differently (internal) or because something about the circumstances could have been different (external). Although previous neuroimaging research has shown that the brain's default mode network (DMN) supports upward eCFT, it is unclear how it is differentially recruited during internal versus external upward eCFT. We collected functional magnetic resonance imaging data while participants remembered negative autobiographical memories, generated either internal or external upward eCFT for the memory, and then rated the plausibility, perceived control and difficulty of eCFT generation. Both internal and external eCFT engaged midline regions of cingulate cortex, a central node of the DMN. Most activity differentiating eCFT, however, occurred outside the DMN. External eCFT engaged cuneus, angular gyrus and precuneus, whereas internal eCFT engaged posterior cingulate and precentral gyrus. Angular gyrus and precuneus were additionally sensitive to perceived plausibility of external eCFT, while postcentral gyrus and insula activity scaled with perceived plausibility of internal eCFT. These results highlight the key brain regions that might be involved in cases of maladaptive mental simulations. This article is part of the theme issue 'Thinking about possibilities: mechanisms, ontogeny, functions and phylogeny'.


Assuntos
Imaginação , Memória Episódica , Humanos , Rememoração Mental , Mapeamento Encefálico , Encéfalo , Imageamento por Ressonância Magnética/métodos
16.
Philos Trans R Soc Lond B Biol Sci ; 377(1866): 20210336, 2022 12 19.
Artigo em Inglês | MEDLINE | ID: mdl-36314152

RESUMO

Imagination is a biological function that is vital to human experience and advanced cognition. Despite this importance, it remains unknown how imagination is realized in the brain. Substantial research focusing on the hippocampus, a brain structure traditionally linked to memory, indicates that firing patterns in spatially tuned neurons can represent previous and upcoming paths in space. This work has generally been interpreted under standard views that the hippocampus implements cognitive abilities primarily related to actual experience, whether in the past (e.g. recollection, consolidation), present (e.g. spatial mapping) or future (e.g. planning). However, relatively recent findings in rodents identify robust patterns of hippocampal firing corresponding to a variety of alternatives to actual experience, in many cases without overt reference to the past, present or future. Given these findings, and others on hippocampal contributions to human imagination, we suggest that a fundamental function of the hippocampus is to generate a wealth of hypothetical experiences and thoughts. Under this view, traditional accounts of hippocampal function in episodic memory and spatial navigation can be understood as particular applications of a more general system for imagination. This view also suggests that the hippocampus contributes to a wider range of cognitive abilities than previously thought. This article is part of the theme issue 'Thinking about possibilities: mechanisms, ontogeny, functions and phylogeny'.


Assuntos
Hipocampo , Memória Episódica , Humanos , Hipocampo/fisiologia , Imaginação/fisiologia , Neurônios/fisiologia , Rememoração Mental
17.
Trends Cogn Sci ; 26(12): 1079-1089, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36195539

RESUMO

We propose that older adults' ability to retrieve episodic autobiographical events, although often viewed through a lens of decline, reveals much about what is preserved and prioritized in cognitive aging. Central to our proposal is the idea that the so-called gist of an autobiographical event is not only spared with normal aging but also well adapted to serve memory-guided behavior in older age. To support our proposal, we review cognitive and brain evidence indicating an age-related shift toward gist memory. We then discuss why this shift likely arises from more than age-related decline and instead partly reflects a natural, arguably adaptive, outcome of experience, motivation, and mode-of-thinking factors. Our proposal reveals an upside of age-related memory changes and identifies important research questions.


Assuntos
Envelhecimento Cognitivo , Memória Episódica , Humanos , Idoso , Envelhecimento/psicologia , Motivação , Encéfalo , Rememoração Mental
18.
J Neurosci ; 42(46): 8742-8753, 2022 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-36302636

RESUMO

Mnemonic discrimination, a cognitive process that relies on hippocampal pattern separation, is one of the first memory domains to decline in aging and preclinical Alzheimer's disease. We tested whether functional connectivity (FC) within the entorhinal-hippocampal circuit, measured with high-resolution resting state fMRI, is associated with mnemonic discrimination and amyloid-ß (Aß) pathology in a sample of 64 cognitively normal human older adults (mean age, 71.3 ± 6.4 years; 67% female). FC was measured between entorhinal-hippocampal circuit nodes with known anatomical connectivity, as well as within cortical memory networks. Aß pathology was measured with 18F-florbetapir-PET, and neurodegeneration was assessed with subregional volume from structural MRI. Participants performed both object and spatial versions of a mnemonic discrimination task outside of the scanner and were classified into low-performing and high-performing groups on each task using a median split. Low object mnemonic discrimination performance was specifically associated with increased FC between anterolateral entorhinal cortex (alEC) and dentate gyrus (DG)/CA3, supporting the importance of this connection to object memory. This hyperconnectivity between alEC and DG/CA3 was related to Aß pathology and decreased entorhinal cortex volume. In contrast, spatial mnemonic discrimination was not associated with altered FC. Aß was further associated with dysfunction within hippocampal subfields, particularly with decreased FC between CA1 and subiculum as well as reduced volume in these regions. Our findings suggest that Aß may indirectly lead to memory impairment through entorhinal-hippocampal circuit dysfunction and neurodegeneration and provide a mechanism for increased vulnerability of object mnemonic discrimination.SIGNIFICANCE STATEMENT Mnemonic discrimination is a critical episodic memory process that is performed in the dentate gyrus (DG) and CA3 subfield of the hippocampus, relying on input from entorhinal cortex. Mnemonic discrimination is particularly vulnerable to decline in older adults; however, the mechanisms behind this vulnerability are still unknown. We demonstrate that object mnemonic discrimination impairment is related to hyperconnectivity between the anterolateral entorhinal cortex and DG/CA3. This hyperconnectivity was associated with amyloid-ß pathology and neurodegeneration in entorhinal cortex, suggesting aberrantly increased network activity is a pathological process. Our findings provide a mechanistic explanation of the vulnerability of object compared to spatial mnemonic discrimination in older adults and has translational implications for choice of outcome measures in clinical trials for Alzheimer's disease.


Assuntos
Doença de Alzheimer , Memória Episódica , Humanos , Feminino , Idoso , Pessoa de Meia-Idade , Masculino , Doença de Alzheimer/diagnóstico por imagem , Doença de Alzheimer/patologia , Hipocampo/metabolismo , Córtex Entorrinal/metabolismo , Peptídeos beta-Amiloides/metabolismo , Imageamento por Ressonância Magnética
19.
J Psychiatr Res ; 155: 483-492, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36183602

RESUMO

Stress has a detrimental impact on memory, the hippocampus, and psychological health. Psychopathology research on stress has centered mainly on psychiatric diagnoses rather than symptom dimensions, and less attention has been given to the neurobiological factors through which stress might be translated into psychopathology. The present work investigates the transdiagnostic relationship of cumulative stress with episodic memory and the hippocampus (both structure and function) and explores the extent to which stress mediates the relationship between personality psychopathology and hippocampal size and activation. Cumulative lifetime stress was assessed in a sample of females recruited to vary in stress exposure and severity of personality psychopathology. Fifty-six participants completed subjective and objective tests of episodic memory, a T2-weighted high-resolution magnetic resonance imaging (MRI) scan of the medial-temporal lobe, and functional MRI (fMRI) scanning during a learning and recognition memory task. Higher cumulative stress was significantly related to memory complaints (but not episodic memory performance), lower bilateral hippocampal volume, and greater encoding-related hippocampal activation during the presentation of novel stimuli. Furthermore, cumulative stress significantly mediated the relationship between personality psychopathology and both hippocampal volume and activation, whereas alternative mediation models were not supported. The findings suggest that structural and functional activation differences in the hippocampus observed in case-control studies of psychiatric diagnoses may share cumulative stress as a common factor, which may mediate broadly reported relationships between psychopathology and hippocampal structure and function.


Assuntos
Hipocampo , Memória Episódica , Feminino , Hipocampo/diagnóstico por imagem , Hipocampo/patologia , Humanos , Imageamento por Ressonância Magnética/métodos , Testes Neuropsicológicos , Personalidade , Transtornos da Personalidade/diagnóstico por imagem , Transtornos da Personalidade/etiologia , Lobo Temporal
20.
Nat Commun ; 13(1): 6162, 2022 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-36257934

RESUMO

Episodic memories, or consciously accessible memories of unique events, represent a key aspect of human cognition. Evidence from rodent models suggests that the neural representation of these complex memories requires cooperative firing of groups of neurons on short time scales, organized by gamma oscillations. These co-firing groups, termed "neuronal assemblies," represent a fundamental neurophysiological unit supporting memory. Using microelectrode data from neurosurgical patients, we identify neuronal assemblies in the human MTL and show that they exhibit consistent organization in their firing pattern based on gamma phase information. We connect these properties to memory performance across recording sessions. Finally, we describe how human neuronal assemblies flexibly adjust over longer time scales. Our findings provide key evidence linking assemblies to human episodic memory for the first time.


Assuntos
Memória Episódica , Neurônios , Humanos , Neurônios/fisiologia , Microeletrodos
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