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1.
BMC Geriatr ; 22(1): 469, 2022 05 31.
Artigo em Inglês | MEDLINE | ID: mdl-35641909

RESUMO

BACKGROUND: Research to date offers mixed evidence about the relationship between quality of life and severity of cognitive impairment in people with dementia. We aimed to investigate longitudinal changes in patient- and proxy-rated health-related quality of life (HRQL) by severity of dementia and explore factors associated with changes in HRQL over a one-year period. We used data from the MODEM longitudinal cohort study which recruited dyads of persons with clinically diagnosed dementia and their principal carer and interviewed them face-to-face at baseline and again 1 year later. METHODS: Quota sampling was used to generate balanced numbers (target n = 100 for each severity level) of people with mild cognitive impairment (20+ on the standardised Mini-Mental State Examination (sMMSE)), moderate cognitive impairment (score 10 to 19), and severe cognitive impairment (score 0 to 9). Persons with dementia without an identifiable family carer or other informant (e.g., a formal/professional/paid carer) were excluded from the study. Participants answered a series of questions measuring their HRQL: DEMQOL, DEMQOL-proxy, EQ-5D-3 L, EQ-5D-3L proxy. Multiple regression models were built to understand the effects of baseline demographics and dementia symptoms (cognitive impairment, neuropsychiatric symptoms) on change in HRQL over 1 year. RESULTS: Two hundred and forty-three dyads of people with clinically diagnosed dementia and carers completed baseline and follow-up interviews. Most measures of HRQL remaining relatively stable between time-points, but one index of HRQL, EQ-5D proxy, significantly declined. Depending on the HRQL measure, different factors were associated with change in HRQL. The only factor consistently associated with decline in HRQL (when compared to improvement) was having a diagnosis of a non-Alzheimer's dementia. CONCLUSIONS: Deterioration in HRQL is not an inevitable part of the dementia journey. However, people with non-Alzheimer's dementias may be more susceptible to HRQL decline. This may indicate that those with non-Alzheimer's dementia may benefit from specific support focussed on maintaining their quality of life.


Assuntos
Demência , Qualidade de Vida , Estudos de Coortes , Demência/diagnóstico , Demência/epidemiologia , Demência/psicologia , Humanos , Estudos Longitudinais , Modems , Qualidade de Vida/psicologia , Inquéritos e Questionários
2.
PLoS One ; 16(11): e0259776, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34780522

RESUMO

The average geodesic distance L Newman (2003) and the compactness CB Botafogo (1992) are important graph indices in applications of complex network theory to real-world problems. Here, for simple connected undirected graphs G of order n, we study the behavior of L(G) and CB(G), subject to the condition that their order |V(G)| approaches infinity. We prove that the limit of L(G)/n and CB(G) lies within the interval [0;1/3] and [2/3;1], respectively. Moreover, for any not necessarily rational number ß ∈ [0;1/3] (α ∈ [2/3;1]) we show how to construct the sequence of graphs {G}, |V(G)| = n → ∞, for which the limit of L(G)/n (CB(G)) is exactly ß (α) (Theorems 1 and 2). Based on these results, our work points to novel classification possibilities of graphs at the node level as well as to the information-theoretic classification of the structural complexity of graph indices.


Assuntos
Modelos Teóricos , Algoritmos , Humanos , Modems
3.
Contemp Clin Trials ; 107: 106495, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34216814

RESUMO

Weight loss improves overall health, and reduces inflammation, risk of stroke, heart attack, diabetes, certain cancers, and death among individuals with obesity. Weight loss also improves mobility, increases stamina, and elevates mood. Between 25 and 33% of people with Multiple Sclerosis (pwMS) have obesity. Multiple Sclerosis (MS) and obesity are independently associated with reduced mobility, increased fatigue, and depression. Most behavioral weight loss trials exclude individuals with neurologic disease. Consequently, few studies have examined the effects of weight loss on symptom presentation and health outcomes among pwMS and obesity. This is the first study examining the efficacy of a comprehensive behavioral weight loss intervention designed specifically for pwMS. The purpose of this study is to develop and assess the efficacy of a telehealth administered weight loss intervention tailored for pwMS. Additionally, we aim to determine if weight loss reduces physical and emotional symptoms in individuals with obesity and MS. We will enroll 70 pwMS in a wait-list crossover trial to examine the efficacy of our intervention. If successful, findings will help determine whether we can help participants lose clinically significant weight - and whether weight loss among pwMS and overweight/obesity reduces fatigue, and improves mobility, mood, and quality of life.


Assuntos
Esclerose Múltipla , Telemedicina , Adulto , Dieta , Humanos , Modems , Esclerose Múltipla/terapia , Obesidade/complicações , Obesidade/terapia , Qualidade de Vida , Redução de Peso
4.
Invest Ophthalmol Vis Sci ; 61(10): 54, 2020 08 03.
Artigo em Inglês | MEDLINE | ID: mdl-32866268

RESUMO

Purpose: The spatial distribution of collagen fibril dispersion has a significant impact on both corneal biomechanical and optical behaviors. The goal of this study was to demonstrate a novel method to characterize collagen fibril dispersion using intraocular pressure (IOP)-induced changes in corneal optical aberrations for individualized finite-element (FE) modeling. Methods: The method was tested through both numerical simulations and ex vivo experiments. Inflation tests were simulated in FE models with three assumed patterns of collagen fibril dispersion and experimentally on three rhesus monkey corneas. Geometry, matrix stiffness, and the IOP-induced changes in wavefront aberrations were measured, and the collagen fibril dispersion was characterized. An individualized corneal model with customized collagen fibril dispersion was developed, and the estimated optical aberrations were compared with the measured data. Results: For the theoretical investigations, three assumed distributions of fibril dispersion were all successfully characterized. The estimated optical aberrations closely matched the measured data, with average root-mean-square (RMS) differences of 0.29, 0.24, and 0.10 µm for the three patterns, respectively. The overall features of the IOP-induced changes in optical aberrations were estimated for two ex vivo monkey corneas, with average RMS differences of 0.57 and 0.43 µm. Characterization of the fibril dispersion in the third cornea might have been affected by corneal hydration, resulting in an increased RMS difference, 0.8 µm. Conclusions: A more advanced corneal model with individualized distribution of collagen fibril dispersion can be developed and used to improve our ability to understand both biomechanical and optical behaviors of the cornea.


Assuntos
Colágeno/fisiologia , Córnea/fisiologia , Animais , Fenômenos Biomecânicos , Córnea/patologia , Análise de Elementos Finitos , Pressão Intraocular , Macaca mulatta , Masculino , Modems , Transtornos da Visão/etiologia , Transtornos da Visão/patologia
5.
BMC Geriatr ; 20(1): 232, 2020 07 06.
Artigo em Inglês | MEDLINE | ID: mdl-32631252

RESUMO

BACKGROUND: Due to the progressive nature of dementia, it is important to understand links between disease severity and health-related outcomes. The aim of this study is to explore the relationship between disease severity and the quality of life (QoL) of people with dementia and their family carers using a number of disease-specific and generic measures. METHODS: In the MODEM cohort study, three-hundred and seven people with clinically diagnosed dementia and their carers were recruited on a quota basis to provide equal numbers of people with mild (standardised Mini-Mental State Examination (sMMSE), n = 110), moderate (sMMSE 10-19, n = 100), and severe (sMMSE 0-9, n = 97) cognitive impairment. A series of multiple regression models were created to understand the associations between dementia severity and the QoL of people with dementia and the QoL of their carers. QoL was measured using self- (DEMQOL, EQ-5D, CASP-19) and proxy-reports (DEMQOL-Proxy, EQ-5D) of disease-specific and generic QoL of the person with dementia. Carer generic QoL was measured by self-report (EQ-5D, SF-12). RESULTS: Disease severity, as measured by the sMMSE, was not significantly associated with the QoL of the person with dementia or the carer (p > 0.05), even after controlling for potential confounding variables for self-reported instruments. Proxy measures (rated by the carer) differed systematically in that there were small, but statistically significant proportions of the variance of QoL was explained by severity of cognitive impairment in multiple adjusted models. We also found little in the way of statistically significant relationships between the QoL of people with dementia and that of their carers except between DEMQOL-Proxy scores and the carer EQ-5D scores and carer SF-12 mental sub-scores. CONCLUSIONS: The data generated supports the somewhat counterintuitive argument that severity of cognitive impairment (and therefore severity of dementia) is not associated with lower QoL for the person with dementia when self-report measures are used. However, in absolute terms, as judged by the variance in the multivariate models, it is clear that the contribution of dementia severity to the QoL of people with dementia is minimal whatever the measurement used, be it self- or proxy-rated, or disease-specific or generic.


Assuntos
Demência , Qualidade de Vida , Cuidadores , Estudos de Coortes , Estudos Transversais , Demência/diagnóstico , Humanos , Modems , Psicometria , Índice de Gravidade de Doença , Inquéritos e Questionários
6.
J Gastroenterol Hepatol ; 35(9): 1636-1643, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32333452

RESUMO

BACKGROUND AND AIMS: There are sparse data on the epidemiology of fatty liver in the elderly Asian population. We evaluated for predictors of fatty liver and high risk of advanced fibrosis in a community-based elderly population. METHODS: A total of 1091 participants (mean age was 74.6 ± 6.3 years) were enrolled from 2017 to 2018. Subjects with age younger than 65 years, alcoholism, and history of hepatitis B and hepatitis C were excluded. Fatty liver was diagnosed with abdominal ultrasound by using ultrasonographic fatty liver indicator, a semi-quantitative measurement grading the severity (normal, mild, and moderate-to-severe). Fibrosis-4 score was used for the prediction of the high risk of advanced fibrosis. Using a multivariable logistic regression model, we identified predictors of fatty liver and high risk of advanced fibrosis. RESULTS: In this ambulatory elderly Asian population, the prevalence of fatty liver is 41.9% and of high risk of advanced fibrosis is 12.3%. The prevalence of fatty liver decreases (44.5% to 31.8%), and the high risk of advanced fibrosis increases (3.9% to 27.0%) with aging significantly (both P < 0.05). Metabolic syndrome is a risk factor for fatty liver (odds ratio [OR], 3.19; 95% CI, 2.41-4.22) but not for high risk of advanced fibrosis (OR, 0.67; 95% CI, 0.41-1.08). Hypertriglyceridemia decreases the risk for high risk of advanced fibrosis (OR, 0.53; 95% CI, 0.33-0.87). CONCLUSION: Fatty liver is prevalent in the ambulatory elderly Asian population, affecting over 40% of this population. Age is a risk factor for high risk of advanced fibrosis, with the disease likely progressing from a steatotic to a fibrotic picture with age.


Assuntos
Fígado/patologia , Hepatopatia Gordurosa não Alcoólica/epidemiologia , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Feminino , Fibrose , Humanos , Hipertrigliceridemia , Fígado/diagnóstico por imagem , Cirrose Hepática/diagnóstico por imagem , Cirrose Hepática/etiologia , Cirrose Hepática/patologia , Masculino , Síndrome Metabólica/complicações , Modems , Hepatopatia Gordurosa não Alcoólica/diagnóstico por imagem , Hepatopatia Gordurosa não Alcoólica/etiologia , Hepatopatia Gordurosa não Alcoólica/patologia , Prevalência , Fatores de Risco , Ultrassonografia
7.
BMJ Open Respir Res ; 7(1)2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32161065

RESUMO

BACKGROUND: Advances in technology means that domiciliary non-invasive ventilation (NIV) devices can be remotely monitored via modems in patients' homes. Possible benefits and challenges of modem technology have yet to be established. This study explored the perspectives and experiences of patients, their carers and healthcare professionals (HCPs) on the addition of modem technology in managing home NIV. METHODS: A qualitative study using a combination of focus groups for HCPs and interviews for carers/patients was undertaken. 12 HCPs and 22 patients/carers participated. These focus groups and interviews were audio-recorded, transcribed verbatim and analysed thematically. RESULTS: Five main themes were identified. 'Surveillance: a paradox of findings': HCPs were concerned about unduly scrutinising patients' lives, potentially impacting on HCP patient relationships. Conversely, patients welcomed modem monitoring and did not express concerns regarding invasion of privacy. 'Sanctions': HCPs reported the modem increased access to care and allowed appropriate assessment of ongoing treatment. 'Complacency and ethics': HCPs expressed concerns patients may become complacent in seeking help due to expectations of modem monitoring, as well as being concerned regarding the ethics of modems. There was a suggestion patients and carers' expectations of monitoring were different to that of clinical practice, resulting in complacency in some cases. 'Increased time for patient focused care': HCPs in the focus groups described a number of ways in which using modems was more efficient. 'Confidence: can be improved with technology': patients and carers were positive about the impact of the modems on their health and well-being, particularly their confidence. CONCLUSION: HCPs expressed concerns about surveillance were not corroborated by patients, suggesting acceptability of remote monitoring. Data suggests a need for increased clarity to patients/carers regarding clinical practice relating to responsiveness to modem data. The issue of complacency requires further consideration. Modem technology was acceptable and considered a useful addition by HCPs, patients and carers. TRIAL REGISTRATION NUMBER: NCT03905382.


Assuntos
Cuidadores/psicologia , Pessoal de Saúde/psicologia , Modems/instrumentação , Ventilação não Invasiva/instrumentação , Ventilação não Invasiva/psicologia , Pacientes/psicologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Atenção à Saúde , Feminino , Grupos Focais , Humanos , Londres , Masculino , Pessoa de Meia-Idade , Monitorização Fisiológica/instrumentação , Pesquisa Qualitativa
8.
Community Ment Health J ; 55(4): 578-588, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30276504

RESUMO

There is increasing demand for comprehensive community healthcare that integrates community mental health and primary care services. The Canadian Mental Health Association-Durham Branch provides an example of how the Integrated Health Hub (IHH) Model evolved organically to meet this need. The Framework Method was used to analyze interviews and focus groups with 29 participants. Results reveal five key domains critical to the development of the IHH Model (1) Communication; (2) Hub 'Nuances'; (3) Leadership; (4) Staff; and (5) Challenges. These findings provide insights for other community mental health organizations wishing to provide comprehensive integrated community healthcare services.


Assuntos
Serviços Comunitários de Saúde Mental/organização & administração , Prestação Integrada de Cuidados de Saúde/organização & administração , Atenção Primária à Saúde/organização & administração , Grupos Focais , Humanos , Entrevistas como Assunto , Liderança , Modems , Ontário
9.
IEEE Trans Biomed Circuits Syst ; 13(1): 135-144, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30418920

RESUMO

Ultrasound waves pose a promising alternative to the commonly used electromagnetic waves for intra-body communication. This due to the lower ultrasound wave attenuation, the reduced health risks, and the reduced external interference. Current state-of-the-art ultrasound designs, however, are limited in their practical in-body deployment and reliability. This stems from their use of bulky, focused transducers, the use of simple modulation schemes or the absence of a realistic test environment and corresponding realistic channel models. Therefore, this paper proposes a new, ultrasound, static emulation test bed consisting of small, omnidirectional transducers, and custom gelatin phantoms with additional scattering materials. Using this test bed, we investigate different in-body communication scenarios. Multiple communication channels were extracted and mapped onto finite impulse response (FIR) channel models, which are verified and open sourced for future research. Furthermore, a basic quadrature-amplitude modulation (QAM) modem was built to assess the communication performance under various modulation schemes. A link was established using 4-QAM and 200 kbit/s resulting in a BER <1e-4 at received Eb/No of 13dB. Identical results were obtained by computer simulations on the FIR channels, which makes the extracted FIR channels suitable for the design of future ultrasound in-body communication schemes.


Assuntos
Comunicação , Modelos Teóricos , Modems , Ultrassonografia/métodos , Simulação por Computador , Gelatina/química , Análise dos Mínimos Quadrados , Imagens de Fantasmas
10.
Conscious Cogn ; 62: 82-101, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29747119

RESUMO

Despite increasing interest in effects of meditation, systematic in-depth research on how it qualitatively feels to engage in different kinds of contemplative practices is still missing. To fill this gap, we explore the validity of Micro-phenomenological Interviews (MpI) to assess experiences during breathing meditation (BM), observing-thought meditation (OTM), and loving-kindness meditation (LKM). We performed psycholinguistic analyses, quantitative ratings and qualitative explorations of 104 MpI (N = 57). All results reveal differential affective, bodily and sensorial fingerprints: BM-transcripts contain the most body-related vocabulary, specifically sensations in nose and abdomen. OTM-transcripts contain the most cognition-related vocabulary. OTM is experienced in head and face. LKM-transcripts contain the most vocabulary related to socio-affective processes. LKM is associated to love, sensations around the heart, and warmth. The LKM-outcomes were replicated with another independent set of MpI. These findings verify the merit of MpI as a scientific tool to gain reliable first-person data beyond questionnaires or rating scales.


Assuntos
Meditação/psicologia , Processos Mentais , Adulto , Temperatura Corporal , Percepção de Cores , Emoções , Feminino , Humanos , Entrevistas como Assunto , Linguística , Masculino , Pessoa de Meia-Idade , Modems , Percepção , Adulto Jovem
11.
BMC Oral Health ; 18(1): 37, 2018 03 12.
Artigo em Inglês | MEDLINE | ID: mdl-29530026

RESUMO

BACKGROUND: Mexican immigrants in the United States suffer from poor oral health. The objective of the current study was to explore the utility of applying theory-based factors associated with seeking preventive dental care in a sample of Mexican American adults. METHODS: Data were collected from a cross-sectional survey of a sample of 157 people of Mexican origin (64% female; age 34 ± 11 years) recruited primarily from church congregations and lay community organizations in Central Indiana. Using the Integrative Model of Behavioral Prediction as the guiding framework, structural equation modeling was used to test factors associated with intention to seek preventive dental care. RESULTS: Attitude towards seeking preventive dental care (estimate = 0.37; p < .0001) and self-efficacy for seeking preventive dental care (estimate = 0.68; p < .0001) were associated with intention to seek preventive dental care. The association between dental beliefs and intention to seek preventive dental care was mediated by attitude and self-efficacy (indirect effect = 0.26, p = .002), and the association between past behavior and intention to seek preventive dental care was mediated by self-efficacy (indirect effect = 0.26, p = .003). CONCLUSIONS: These findings suggest that interventions to increase preventive dental care seeking behavior among Mexican Americans should focus on changing attitudes toward seeking preventive dental care and on increasing self-efficacy to seek preventive dental care. Findings also support the use of interventions to influence dental beliefs.


Assuntos
Emigrantes e Imigrantes/estatística & dados numéricos , Americanos Mexicanos/estatística & dados numéricos , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Odontologia Preventiva/estatística & dados numéricos , Adulto , Estudos Transversais , Emigrantes e Imigrantes/psicologia , Feminino , Humanos , Indiana , Masculino , Americanos Mexicanos/psicologia , Modems
12.
Urologia ; 84(4): 209-214, 2017 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-28967061

RESUMO

OBJECTIVE: The purpose of this study was to evaluate the effects of 3G+wifi modems on human sperm quality.A total of 40 semen specimens were gathered between March and September 2015, from healthy adult men. METHODS: The sperm samples were divided into two groups - 3G+wi-fi exposed and unexposed groups. In the unexposed group, the specimens were shielded by aluminum foil in three layers and put into an incubator at a temperature of 37°C for 50 minutes. The exposed group was positioned in another room in an incubator at a temperature of 37°C for 50 minutes. A 3G+wi-fi modem was put into the same incubator and a laptop computer was connected to the modem and was downloading for the entire 50 minutes.Semen analysis was done for each specimen and comparisons between parameters of the two groups were done by using Kolmogorov-Smirnov study and a paired t-test. RESULTS: Mean percentage of sperm with class A and B motility were not significantly different in two groups (p = 0.22 and 0.54, respectively). In class C, it was significantly lower in the exposed group (p = 0.046), while in class D it was significantly higher (p = 0.022).Velocity curvilinear, velocity straight line, velocity average path, mean angular displacement, lateral displacement and beat cross frequency were significantly higher in the unexposed group. The limitation was the in vitro design. CONCLUSIONS: Electromagnetic waves (EMWs) emitted from 3G+wi-fi modems cause a significant decrease in sperm motility and velocity, especially in non-progressive motile sperms. Other parameters of semen analysis did not change significantly.EMWs, which are used in communications worldwide, are a suspected cause of male infertility. Many studies evaluated the effects of cell phones and wi-fi on fertility. To our knowledge, no study has yet been done to show the effects of EMWs emitted from 3G+wi-fi modems on fertility.Our study revealed a significant decrease in the quality of human semen after exposure to EMWs emitted from 3G+wi-fi modems.


Assuntos
Radiação Eletromagnética , Modems , Análise do Sêmen , Espermatozoides/efeitos da radiação , Adulto , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
13.
Telemed J E Health ; 23(1): 49-54, 2017 01.
Artigo em Inglês | MEDLINE | ID: mdl-27267769

RESUMO

INTRODUCTION: The success of a newborn hearing screening program depends on successful tracking and follow-up to ensure that children who have had positive screening results in the first few days of life receive appropriate and timely diagnostic and intervention services. The easy availability, through a suitable infrastructure, of the data necessary for the tracking, diagnosis, and care of children concerned is a major key to enhancing the quality and efficiency of newborn hearing screening programs. MATERIALS AND METHODS: Two systems for the automated two-way transmission of newborn hearing screening and configuration data, based on mobile communication technology, for the screening devices MADSEN AccuScreen® and Natus Echo-Screen® were developed and tested in a field study. Radio modem connections were compared with conventional analogue modem transmissions from Natus Echo-Screen devices for duration, transmission rate, number of lost connections, and frequency of use. RESULTS: The average session duration was significantly lower with the MADSEN AccuScreen (12 s) and Natus Echo-Screen both with radio modem (15 s) than the Natus Echo-Screen with analogue modem (108 s). The transmission rate was significantly higher (898 and 1,758 vs. 181 bytes/s) for the devices with radio modems. Both radio modem devices had significantly lower rates of broken connections after initial connection (2.1 and 0.9 vs. 5.5%). An increase in the frequency of data transmission from the clinics with mobile radio devices was found. CONCLUSIONS: The use of mobile communication technology in newborn hearing screening devices offers improvements in the average session duration, transmission rate, and reliability of the connection over analogue solutions. We observed a behavioral change in clinical staff using the new technology: the data exchange with the tracking center is more often used. The requirements for on-site support were reduced. These savings outweigh the small increase in costs for the Internet service provider.


Assuntos
Testes Auditivos/instrumentação , Modems/instrumentação , Telemedicina/instrumentação , Testes Auditivos/normas , Humanos , Recém-Nascido , Modems/normas , Reprodutibilidade dos Testes , Fatores de Tempo
14.
Masui ; 65(8): 863-868, 2016 Sep.
Artigo em Japonês | MEDLINE | ID: mdl-30351605

RESUMO

Modern anesthesiology in Japan developed after Meyer Sakad's lectures at the Japanese-American Joint Conference on Medical Education (JAJCME) in 1950. To assess their influence on the subsequent advance in the specialty, the author surveyed Japanese clinical journals between 1949 and 1953 to find special issues on anesthesiology. Only two special issues were found in the journals published in March 1951 and February 1953. Because the former issue in the jour- nal "Rinsho" was published before Maeda's presidential address in 1951 at the Annual Meeting of the 51st Japan Surgical Society and Volpitto's lectures at the second JAJCME in 1952, the influence of Maeda's and Volpitto's lectures is excluded from this issue. The traces of Saklad's influence are detected only in two articles by Shimizu et al and Maeda et al, who enjoyed Saklad's lectures.


Assuntos
Anestesiologia/história , Anestesiologia/educação , Educação Médica , História do Século XX , Japão , Modems
15.
J Chem Phys ; 141(12): 124103, 2014 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-25273408

RESUMO

Features of path dependent energy transfer in a dual-ring light-harvesting (LH2) complexes (B850) system have been examined in detail systematically. The Frenkel-Dirac time dependent variational method with the Davydov D1 Ansatz is employed with detailed evolution of polaron dynamics in real space readily obtained. It is found that the phase of the transmission amplitude through the LH2 complexes plays an important role in constructing the coherent excitonic energy transfer. It is also found that the symmetry breaking caused by the dimerization of bacteriochlorophylls and coherence or correlation between two rings will be conducive in enhancing the exciton transfer efficiency.


Assuntos
Transferência de Energia , Complexos de Proteínas Captadores de Luz/química , Modems , Proteobactérias/química , Algoritmos , Teoria da Informação , Teoria Quântica
16.
J Cell Sci ; 127(Pt 13): 2934-43, 2014 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-24706947

RESUMO

Acidic organelles form an important intracellular Ca(2+) pool that can drive global Ca(2+) signals through coupling with endoplasmic reticulum (ER) Ca(2+) stores. Recently identified lysosome-ER membrane contact sites might allow formation of Ca(2+) microdomains, although their size renders observation of Ca(2+) dynamics impractical. Here, we generated a computational model of lysosome-ER coupling that incorporated a previous model of the inositol trisphosphate (IP3) receptor as the ER Ca(2+) 'amplifier' and lysosomal leaks as the Ca(2+) 'trigger'. The model qualitatively described global Ca(2+) responses to the lysosomotropic agent GPN, which caused a controlled but substantial depletion of small solutes from the lysosome. Adapting this model to physiological lysosomal leaks induced by the Ca(2+) mobilising messenger NAADP demonstrated that lysosome-ER microdomains are capable of driving global Ca(2+) oscillations. Interestingly, our simulations suggest that the microdomain [Ca(2+)] need not be higher than that in the cytosol for responses to occur, thus matching the relatively high affinity of IP3 receptors for Ca(2+). The relative distribution and overall density of the lysosomal leaks dictated whether microdomains triggered or modulated global signals. Our data provide a computational framework for probing lysosome-ER Ca(2+) dynamics.


Assuntos
Canais de Cálcio/metabolismo , Sinalização do Cálcio/fisiologia , Cálcio/metabolismo , Retículo Endoplasmático/metabolismo , Lisossomos/metabolismo , NADP/análogos & derivados , Feminino , Humanos , Microdomínios da Membrana/metabolismo , Modems , NADP/metabolismo
17.
Gene ; 538(2): 334-41, 2014 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-24480448

RESUMO

Chalcone-flavanone isomerase (CHI; EC 5.5.1.6.) participates in the early step of flavonoid biosynthesis, related to plant adaptive and protective responses to environmental stress. The bread wheat genomic sequences encoding CHI were isolated, sequenced and mapped to the terminal segment of the long arms of chromosomes 5A, 5B and 5D. The loss of the final Chi intron and junction of the two last exons was found in the wheat A, B and D genomes compared to the Chi sequences of most other plant species. Each of the three diploid genomes of hexaploid wheat encodes functional CHI; however, transcription of the three homoeologous genes is not always co-regulated. In particular, the three genes demonstrated different response to salinity in roots: Chi-D1 was up-regulated, Chi-A1 responds medially, whereas Chi-B1 was not activated at all. The observed variation in transcriptional activity between the Chi homoeologs is in a good agreement with structural diversification of their promoter sequences. In addition, the correlation between Chi transcription and anthocyanin pigmentation in different parts of wheat plant has been studied. The regulatory genes controlling anthocyanin pigmentation of culm and pericarp modulated transcription of the Chi genes. However, in other organs, there was no strong relation between tissue pigmentation and the transcription of the Chi genes, suggesting complex regulation of the Chi expression in most parts of wheat plant.


Assuntos
Genes de Plantas , Liases Intramoleculares/genética , Proteínas de Plantas/genética , Triticum/enzimologia , Triticum/genética , Sequência de Aminoácidos , Sequência de Bases , Cromossomos de Plantas/genética , Clonagem Molecular , DNA de Plantas/genética , Evolução Molecular , Éxons , Expressão Gênica , Liases Intramoleculares/química , Íntrons , Modems , Dados de Sequência Molecular , Filogenia , Proteínas de Plantas/química , Poliploidia , Regiões Promotoras Genéticas , Conformação Proteica , Homologia de Sequência de Aminoácidos , Homologia de Sequência do Ácido Nucleico , Especificidade da Espécie , Distribuição Tecidual
18.
J Diabetes Sci Technol ; 7(3): 623-9, 2013 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-23759394

RESUMO

BACKGROUND: Different types of data transmission technologies are used in remote monitoring (RM) programs. This study reports on a retrospective analysis of how participants engage, based on the type of data transfer technology used in a blood pressure (BP) RM program, and its potential impact on RM program design and outcomes. METHODS: Thirty patients, aged 23-84 years (62 ± 14 years), who had completed at least 2 months in the program and were not participating in any other clinical trial were identified from the Remote Monitoring Data Repository. Half of these patients used wireless-based data transfer devices [wireless-based device (WBD)] while the other half used telephone modem-based data transfer devices [modem-based device (MBD)]. Participants were matched by practice and age. Engagement indices, which include frequency of BP measurements, frequency of data uploads, time to first BP measurement, and time to first data upload, were compared in both groups using the Wilcoxon-Mann-Whitney two-sample rank-sum test. Help desk call data were analyzed by Chi square test. RESULTS: The frequency of BP measurements and data uploads was significantly higher in the WBD group versus the MBD group [median = 0.66 versus 0.2 measurements/day (p = .01) and 0.46 versus 0.01 uploads/day (p < .001), respectively]. Time to first upload was significantly lower in the WBD group (median = 4 versus 7 days; p = .02), but time to first BP measurement did not differ between the two groups (median = 2 versus 1 day; p = .98). CONCLUSION: Wireless transmission ensures instantaneous transmission of readings, providing clinicians timely data to intervene on. Our findings suggest that mobile-enabled wireless technologies can positively impact patient engagement, outcomes, and operational workflow in RM programs.


Assuntos
Telefone Celular , Disseminação de Informação/métodos , Modems/instrumentação , Monitorização Fisiológica/instrumentação , Consulta Remota/instrumentação , Adulto , Idoso , Idoso de 80 Anos ou mais , Pressão Sanguínea , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto Jovem
19.
Comput Math Methods Med ; 2013: 624267, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23662160

RESUMO

Damage to hard bearing surfaces of total joint replacement components typically includes both thin discrete scratches and broader areas of more diffuse scraping. Traditional surface metrology parameters such as average roughness (R a) or peak asperity height (R p) are not well suited to quantifying those counterface damage features in a manner allowing their incorporation into models predictive of polyethylene wear. A diffused lighting technique, which had been previously developed to visualize these microscopic damage features on a global implant level, also allows damaged regions to be automatically segmented. These global-level segmentations in turn provide a basis for performing high-resolution optical profilometry (OP) areal scans, to quantify the microscopic-level damage features. Algorithms are here reported by means of which those imaged damage features can be encoded for input into finite element (FE) wear simulations. A series of retrieved clinically failed implant femoral heads analyzed in this manner exhibited a wide range of numbers and severity of damage features. Illustrative results from corresponding polyethylene wear computations are also presented.


Assuntos
Análise de Falha de Equipamento/estatística & dados numéricos , Prótese Articular , Falha de Prótese , Algoritmos , Biologia Computacional , Simulação por Computador , Análise de Elementos Finitos , Prótese de Quadril , Humanos , Prótese do Joelho , Modems , Fenômenos Ópticos , Fotografação , Polietileno , Propriedades de Superfície
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