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1.
Z Rheumatol ; 80(1): 45-47, 2021 Feb.
Artigo em Alemão | MEDLINE | ID: mdl-33495854

RESUMO

The severe acute respiratory coronavirus type 2 (SARS-CoV-2) pandemic is keeping most countries of the world in suspense. In Germany the prevalence of SARS-CoV­2 infections is under 2% but for weeks the numbers in Germany have also been increasing. The care in rheumatology was temporarily impaired by the first wave of the pandemic. This article reports the infection situation in the largest specialized rheumatology clinic in Germany, the Rheumatism Center Ruhrgebiet, because recently during the second wave for the first time several SARS-CoV­2 infections occurred here over one weekend, which led to considerable anxiety in many of those involved. The situation could be clarified by consistent testing of patients and personnel with the rapid antigen test and the situation could be mollified. Ultimately, only a few persons were tested positive and the courses by the patients have so far remained bland. This shows the effectiveness of the protective hygiene measures consistently implemented since April.


Assuntos
COVID-19 , Doenças Reumáticas , Alemanha/epidemiologia , Hospitais , Humanos , Nafazolina , SARS-CoV-2
2.
Eur J Prosthodont Restor Dent ; 29(1): 47-53, 2021 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-33026719

RESUMO

The objective of this study was to evaluate the use of naphazoline hydrochloride in comparison with aluminum chloride for vertical gingival displacement. The inclusion criteria were: patients with a good general systemic condition; periodontal health; and thick gingival biotype. Moreover, the exclusion criteria were: smoking individuals; canine teeth or central incisors with carious lesions, abrasion, erosion, prosthetic abutments or unsatisfactory restorations; patients with periodontal disease; and users of continuous medication. 72 teeth were included and the Square Block Design was used to randomize the samples. Three measures were obtained from each tooth, and mean vertical gingival displacement was calculated. A descriptive analysis of the average displacement was performed. The normality test used was the Lilliefors' Test and for comparison between treatments, the Kruskal-Wallis Test was used. The Bartlett's Test for homogeneity of variances was used and a 5% (p ⟨ 0.05) significant level was considered. Thus, the Aluminum Chloride and Naphazoline Hydrochloride showed no statistically amount of gingival retraction than the control group (p = 0.3822). The average of gingival vertical displacement in all groups were less than 0,5 mm. The technique used did not allow any amount of horizontal displacement on obtained models.


Assuntos
Técnicas de Retração Gengival , Nafazolina , Cloreto de Alumínio , Dente Canino , Gengiva , Humanos
3.
Comb Chem High Throughput Screen ; 23(10): 1090-1099, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32691707

RESUMO

BACKGROUND: Allergic rhinitis, acute nasal congestion and sinusitis are one of the most common health problems and have a major effect on the quality of life. Several medications are used to improve the symptoms of such diseases in humans. Pharmaceutical pomade form containing Ephedrine (EPD) HCl, Naphazoline (NPZ) HCl, Antazoline (ANT) HCl, and Chlorobutanol (CLO) is one of them. OBJECTIVE: For these reasons, this study includes the development of spectrophotometric and chromatographic methods for the determination of EPD HCl, NPZ HCl, ANT HCl, and CLO active agents in the pharmaceutical pomade. METHOD: In the spectrophotometric method, third-order derivative of the amplitudes at 218 nm n=5 and the first-order derivative of the amplitudes 254 nm n=13 was selected for the determination of EPD, ANT, respectively while NPZ was determined by the second derivative at 234 nm and n=21. Colorimetric detection was applied for assay analysis of CLO at 540 nm. Furthermore, a reverse phase high performance liquid chromatographic (RP- HPLC) method has been developed and optimized by using Agilent Zorbax Eclipse XDB C18 (75 mm x 3.0 mm, 3.5µm) column. The column temperature was 40°C, binary gradient elution was used and the mobile phase consisted of 15 mM phosphate buffer in distilled water (pH 3.0) and methanol, and the flow rate was 0.6 mL min-1 and the UV detector was detected at 210 nm. The linear operating range was obtained as 11.97-70, 0.59-3, 2.79-30, and 2.92-200 µg mL-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO respectively. RESULTS: The LOD values were found to be 3.95, 0.19, 0.92 and 0.96 µg mL-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO in the spectrophotometric method, respectively. The linear ranges in the RP-HPLC method were 8.2-24.36 µg mL-1, 0.083 - 0.75 µg/mL, 2.01-7.5 µg mL-1 and 2.89-24.4 µg mL-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO, respectively. The LOD values in the validation studies were 2.7, 0.025, 0.66 and 0.86 µg mL-1 for EPD HCl, NPZ HCl, ANT HCl, and CLO in RP-HPLC method respectively. CONCLUSION: The results of the spectrophotometric and chromatographic methods were compared and no differences were found between the two methods.


Assuntos
Antazolina/análise , Clorobutanol/análise , Efedrina/análise , Nafazolina/análise , Cromatografia Líquida de Alta Pressão/instrumentação , Desenho de Equipamento , Estrutura Molecular
4.
J Addict Med ; 14(5): e267-e270, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31972770

RESUMO

: The paper describes 2 case reports of non-medical use of Naphazoline (Naphthyzin). Both demonstrate that the peripherally acting alpha-adrenergic agonist Naphazoline obtains some addictive potential. The drug produces a feeling of euphoria, which resembles the perceived effects of psychostimulants. Both patients and people who consume Naphazoline for intoxication report increased tolerance after repeated use which indicates the addictive potential of the substance. To the best of our knowledge, this is the first examination of non-medical Naphazoline use and the first attempt to describe its addictive potential. Clinical psychiatrists should be aware of this phenomenon when addressing polysubstance use behavior.


Assuntos
Nafazolina , Transtornos Relacionados ao Uso de Substâncias , Agonistas alfa-Adrenérgicos , Humanos , Nafazolina/efeitos adversos
5.
Drug Dev Res ; 80(5): 606-616, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30973979

RESUMO

An estimated 50 million people suffer epilepsy worldwide and 30% of the cases do not respond to current antiepileptic drugs (AEDs). Here, we report synthesis and anticonvulsant screening of new derivatives of nafimidone, a well-known member of (arylakyl)azole anticonvulsants. The compounds showed promising protection against maximal electroshock (MES)-induced seizures in mice and rats when administered via intraperitoneal (ip) and oral route. Especially, 5b, 5c, and 5i displayed outstanding activity in rats in MES test when given ip (ED50 : 16.0, 15.8, and 11.8 mg/kg, respectively). Additionally, 5l was active against 6 Hz and corneal-kindled mice models. Behavioral toxicity of the compounds was very low and their therapeutic indexes were high compared to some currently available AEDs. A number of pharmaceutically relevant descriptors and properties were predicted for the compounds in silico in comparison with a set of known drugs. Favorable results were obtained such as good blood-brain barrier permeability and high oral absorption, as well as drug-likeness. 5l was found to show affinity to the benzodiazepine binding site of A-type GABA receptor via molecular docking simulations.


Assuntos
Anticonvulsivantes/síntese química , Eletrochoque/efeitos adversos , Imidazóis/síntese química , Receptores de GABA-A/metabolismo , Convulsões/tratamento farmacológico , Administração Oral , Animais , Anticonvulsivantes/química , Anticonvulsivantes/farmacologia , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Imidazóis/química , Imidazóis/farmacologia , Injeções Intraperitoneais , Masculino , Camundongos , Modelos Moleculares , Simulação de Acoplamento Molecular , Estrutura Molecular , Nafazolina/análogos & derivados , Nafazolina/química , Ratos , Receptores de GABA-A/química , Convulsões/etiologia , Convulsões/metabolismo , Relação Estrutura-Atividade
6.
Res Social Adm Pharm ; 15(8): 943-948, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30737195

RESUMO

BACKGROUND: There has been a trend in the past five years in Jordan for ophthalmic anticholinergic preparations to be misused or abused. This is done mainly to experience mental altering effects such as mood changes, euphoria or hallucinations. Such products are mostly obtained from community pharmacies without a prescription. OBJECTIVES: This study aimed to observe the requests of ophthalmic preparations in community pharmacies in Amman, Jordan, and evaluating the most popular and frequently requested ophthalmic drops suspected of abuse. Also, it aimed to describe the current methods that Jordanian community pharmacists use to manage such requests. METHODS: A prospective cross-sectional observational study was conducted between November 2016 and January 2017 at sixteen different community pharmacies in Amman. All ophthalmic products requested were observed during this period. RESULTS: A total of 140 ophthalmic product requests for 130 customers were observed. Dry eye was the most common complaint for which the customer requested the medication (n = 30, 23.1%) and direct self-medication (ie-requesting the product by name), was the most frequent method of purchase (n = 63, 48.5%). In 19 cases (14.6%), product requests were suspected to be for non-medical (ie-abuse) purposes. Most of the suspected cases were for Pentolate® (n = 11, 57.9%), whereas 7 were for Prisoline® (36.8%) and 1 for Naphcon-A® (5.3%). The majority of observed cases were for products requested without a prescription (n = 16, 84.2%), and in 12 cases out of which, sale was refused (63.2%). CONCLUSION: More effort and enforcement of pharmacy regulation for safe dispensing is needed to reduce the abuse of ophthalmic products. Educating pharmacists and ophthalmologists would help raise awareness and control the type of drug abuse.


Assuntos
Soluções Oftálmicas/administração & dosagem , Farmácias/estatística & dados numéricos , Transtornos Relacionados ao Uso de Substâncias , Adulto , Compostos de Benzalcônio , Oftalmopatias/tratamento farmacológico , Feminino , Humanos , Jordânia , Masculino , Pessoa de Meia-Idade , Nafazolina , Feniramina , Adulto Jovem
7.
Acta Ophthalmol ; 97(5): 505-509, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30479070

RESUMO

PURPOSE: To investigate whether exposure to antazoline-naphazoline eye drops in the first trimester of pregnancy was associated with an increased risk of malformations in humans. METHODS: All women giving live birth between 1997 and 2011 in Denmark were included in this nationwide cohort study. All women redeeming at least one prescription of antazoline-naphazoline eye drops during the first 84 days of pregnancy were identified. Logistic regression was used to estimate the odds ratios of malformations among exposed offspring compared to non-exposed offspring. RESULTS: We identified 977 706 births between 1997 and 2011. A total of 3061 women (0.32%) were exposed to antazoline-naphazoline eye drops in the first trimester of pregnancy. The rate of congenital malformations was 3.0% (n = 93) in exposed offspring and 3.5% (n = 33 594) in unexposed offspring. First-trimester exposure to antazoline-naphazoline was not associated with major congenital malformations overall (odds ratio: 0.88, 95% confidence interval: 0.71-1.09) or with any specific major malformation. The number of redeemed prescriptions was unchanged during all trimesters of pregnancy as compared to before and after pregnancy (p < 0.05). CONCLUSION: Exposure to antazoline-naphazoline eye drops in the first trimester of pregnancy appears not to be associated with increased teratogenic risk.


Assuntos
Anormalidades Induzidas por Medicamentos/epidemiologia , Antazolina/efeitos adversos , Nafazolina/efeitos adversos , Vigilância da População/métodos , Sistema de Registros , Anormalidades Induzidas por Medicamentos/etiologia , Adulto , Antazolina/administração & dosagem , Antialérgicos/administração & dosagem , Antialérgicos/efeitos adversos , Dinamarca/epidemiologia , Feminino , Seguimentos , Humanos , Incidência , Recém-Nascido , Masculino , Nafazolina/administração & dosagem , Descongestionantes Nasais/administração & dosagem , Descongestionantes Nasais/efeitos adversos , Soluções Oftálmicas , Gravidez , Resultado da Gravidez , Primeiro Trimestre da Gravidez , Estudos Retrospectivos , Fatores de Risco , Adulto Jovem
10.
Arch. argent. pediatr ; 116(4): 626-629, ago. 2018. tab
Artigo em Espanhol | LILACS, BINACIS | ID: biblio-950056

RESUMO

La nafazolina es un fármaco utilizado como descongestivo, generalmente, en pacientes adultos. Su indicación en pediatría no es frecuente; su uso está aprobado a partir de los 12 años por los efectos tóxicos que posee. La intoxicación en niños genera un cuadro clínico potencialmente grave. Se caracteriza por la aparición inmediata de hipotonía, deterioro del sensorio, hipotermia y bradicardia con grado variable de compromiso clínico. Si bien es una intoxicación infrecuente, la anamnesis y el manejo inicial del paciente son la clave en su evolución. Se presenta a un niño de 4 años que, por un error terapéutico, recibió este fármaco y se destaca la instauración rápida y potencialmente grave del cuadro clínico.


Naphazoline is a drug commonly used as a decongestant in adult patients. Its indication in Pediatrics is not frequent, being approved its use from the age of 12 for the toxic effects it possesses. Intoxication in children generates a potentially serious clinical picture. It is characterized by the immediate appearance of hypotonia, deterioration of the sensory, hypothermia and bradycardia of variable degree of clinical compromise. Although it is an infrequent intoxication, the anamnesis and the initial management of the patient are the key in the evolution. We present a 4-year-old boy who, as a therapeutic error, receives this drug, emphasizing the rapid and potentially severe establishment of the clinical picture.


Assuntos
Humanos , Masculino , Pré-Escolar , Descongestionantes Nasais/envenenamento , Erros de Medicação , Nafazolina/envenenamento , Descongestionantes Nasais/administração & dosagem , Índice de Gravidade de Doença , Nafazolina/administração & dosagem
11.
Arch Argent Pediatr ; 116(4): e626-e629, 2018 08 01.
Artigo em Espanhol | MEDLINE | ID: mdl-30016045

RESUMO

Naphazoline is a drug commonly used as a decongestant in adult patients. Its indication in Pediatrics is not frequent, being approved its use from the age of 12 for the toxic effects it possesses. Intoxication in children generates a potentially serious clinical picture. It is characterized by the immediate appearance of hypotonia, deterioration of the sensory, hypothermia and bradycardia of variable degree of clinical compromise. Although it is an infrequent intoxication, the anamnesis and the initial management of the patient are the key in the evolution. We present a 4-year-old boy who, as a therapeutic error, receives this drug, emphasizing the rapid and potentially severe establishment of the clinical picture.


Assuntos
Erros de Medicação , Nafazolina/envenenamento , Descongestionantes Nasais/envenenamento , Pré-Escolar , Humanos , Masculino , Nafazolina/administração & dosagem , Descongestionantes Nasais/administração & dosagem , Índice de Gravidade de Doença
12.
Artigo em Chinês | MEDLINE | ID: mdl-29902847

RESUMO

Objective: To observe the process of nasal mucosa injury and repair induced by nasal decongestants in guinea pigs Methods: Sixty-five male guinea pigs were randomly divided into 4groups by digital random method.The guinea pigs in Group A (20 guinea pigs)were treated with 2 sprays of 0.1% Naphazoline 6 times a day for 2 weeks; Group B (20 guinea pigs)with 2 drops of 1% Ephedrine 6 times a day for 2 weeks; Group C(20 guinea pigs) with 2 sprays of Naphazolin hydrochloride and Chlorphenamine Maleate Nasal Spray 8 times a day for 2 weeks.Group D (5guinea pigs)did not do any intervention as a control group.At the end of first and second weekend, 6 guinea pigs randomly selected from each group were observed the morphological changes of the nasal cavity with nasal endoscope and pathological microscope.Two weeks after stopping use of decongestant, 24 animals were grouped.Three guinea pigs were selected randomly from each group to form Group E (n=9) and Group F (n=9)respectively. The 6 remaining guinea pigs falled into Group G. Group E received 2 sprays of Mometasone Furoate Nasal Spray once a day for 2 weeks; Group F received 1 ml 2.3% saline to wash the nasal cavities once a day for 2 weeks.Group F was used to show the natural progess without any treatment.At the end of the third and fourth weekend, nasal endoscopic and pathological microscopes were used to observe the nasal cavity structure and the pathological changes of nasal mucosa. Results: Nasal mocusa congestion and edema were observed with nasal endoscopy after 2 weeks of using nasal decongestant. Cell edema, blood vessel expansion, acute and chronic inflammatory cell infiltration, cilium lodging or loss were observed under the pathological microscope in GroupA, B, C. After using MometasoneFuroate Nasal Spray and 2.3% saline for 2 weeks, the above changes were all recovered in Group E and F. No recovery was found in Group G. Conclusions: Short-term and over dose of nasal decongestant can result in the injury of nasal mucosa in guinea pigs, and the injury is much severe as using decongestant last longer.MometasoneFuroate nasal spray and 2.3% saline can repair the injury.


Assuntos
Descongestionantes Nasais/efeitos adversos , Mucosa Nasal/efeitos dos fármacos , Animais , Clorfeniramina/efeitos adversos , Efedrina/efeitos adversos , Cobaias , Masculino , Furoato de Mometasona/uso terapêutico , Nafazolina/efeitos adversos , Mucosa Nasal/lesões , Distribuição Aleatória , Suínos
13.
Vestn Otorinolaringol ; 83(2): 46-50, 2018.
Artigo em Russo | MEDLINE | ID: mdl-29697655

RESUMO

Undesirable effects of the application of the intransal vasoconstricting medications are a frequent occurrence in the pediatric practice. The objective of the present study was to evaluate the role of the intranasal vasoconstricting medications in the structure of the means and methods currently available for the treatment of toxicological pathologies based at a multi-field clinical hospital. The retrospective analysis of the medical histories of the patients admitted to the toxicological department and annual reports for the period from 2015 to 2016 was undertaken. The study has demonstrated that intoxication associated with the use of the intranasal vasoconstricting medications was the most common cause of hospitalization of the children in the toxicological departments. Intoxication of this origin accounted for 15-20% of the total number of toxicological pathologies among the children. The cases of intoxication are most frequently documented in the group of children at the age between 1 and 3 years. The risk of the undesirable serious complications is especially high after the application of naphazoline-based intranasal vasoconstricting medications (71.7-77.4% of all the cases of intoxication with these products). It is concluded that the use of intranasal vasoconstricting medications in the pediatric practice should be carried out under the strict control, with the naphazoline-based preparations being totally excluded from the application.


Assuntos
Distúrbios Induzidos Quimicamente , Nafazolina , Descongestionantes Nasais , Obstrução Nasal/tratamento farmacológico , Administração Intranasal/métodos , Distúrbios Induzidos Quimicamente/diagnóstico , Distúrbios Induzidos Quimicamente/etiologia , Distúrbios Induzidos Quimicamente/prevenção & controle , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Nafazolina/administração & dosagem , Nafazolina/efeitos adversos , Descongestionantes Nasais/administração & dosagem , Descongestionantes Nasais/efeitos adversos , Obstrução Nasal/epidemiologia , Estudos Retrospectivos , Medição de Risco , Federação Russa/epidemiologia
16.
Dermatol Surg ; 43(2): 270-274, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27930371

RESUMO

BACKGROUND: Ptosis after botulinum toxin injection is a disturbing complication. Decongestant and antiglaucoma eyedrops are frequently prescribed for temporary improvement of eyelid ptosis. Although frequently cited on informal communications, the effect of these drugs on eyelid position has never been compared in a formal study. OBJECTIVE: To measure the effect of low-concentration, nonmydriatic selective alpha agonist eyedrops on upper eyelid position. METHODS AND MATERIALS: This nonrandomized clinical trial enrolled 20 healthy subjects aged 18 to 50 years. The upper margin-reflex distance (MRD1) was measured before, 30, 60, and 120 minutes after administration of 1 drop of brimonidine 0.2%, phenylephrine 0.12%, or naphazoline 0.05% to the left eye. RESULTS: There was no statistically significant difference in mean MRD1 between the brimonidine and phenylephrine groups when comparing baseline to all other study time points. After administration of naphazoline 0.05%, MRD1 had a mean increase of 0.56 ± 0.11 mm (p < 0.001) after 30 minutes, 0.47 ± 0.12 mm (p = 0.001) after 60 minutes, and 0.26 ± 0.09 mm (p = 0.028) after 120 minutes when compared with baseline. CONCLUSION: Brimonidine 0.2% and phenylephrine 0.12% have no effect on eyelid aperture, but naphazoline 0.05% eyedrops could be useful for temporary relief of upper eyelid ptosis in selected patients.


Assuntos
Agonistas alfa-Adrenérgicos/administração & dosagem , Pálpebras/efeitos dos fármacos , Adolescente , Adulto , Blefaroptose/induzido quimicamente , Blefaroptose/tratamento farmacológico , Toxinas Botulínicas/efeitos adversos , Tartarato de Brimonidina/administração & dosagem , Humanos , Pessoa de Meia-Idade , Nafazolina/administração & dosagem , Soluções Oftálmicas , Fenilefrina/administração & dosagem , Adulto Jovem
17.
Vestn Oftalmol ; 132(5): 81-85, 2016.
Artigo em Russo | MEDLINE | ID: mdl-27911431

RESUMO

Treatment of allergic diseases of eyelids and conjunctiva (conjunctivites and blepharoconjunctivites) often presents difficulties due to peculiarities of their pathogenesis - allergic and vascular reactions, disorder of lacrimal production, meibomian gland dysfunction, and possible bacterial contamination. It has been suggested to use Ocumethyl, which contains zinc sulfate (binding, drying, anti-inflammatory, and antiseptic effect), diphenhydamine hydrochloride (an Н1-antihistamine that decreases capillary permeability and helps resolve conjunctival and eyelid edema), naphazoline hydrochloride (a sympathomimetic notable for its strong, rapid, and long-lasting vasoconstrictive effect), and methylene blue (antiseptic effect, disintoxication, and antioxidant activity). A total of 80 patients with chronic allergic conjunctivitis, blepharoconjuntivitis, or giant papillary conjunctivitis associated with contact lens wearing were treated with Ocumethyl instillations (3 times daily for 15-30 days). A clinically significant effect was obtained in 77-91% of patients depending on the disease entity.


Assuntos
Conjuntivite Alérgica , Difenidramina/administração & dosagem , Doenças Palpebrais , Hipersensibilidade/complicações , Azul de Metileno/administração & dosagem , Nafazolina/administração & dosagem , Sulfato de Zinco/administração & dosagem , Antialérgicos/administração & dosagem , Antialérgicos/efeitos adversos , Conjuntivite Alérgica/diagnóstico , Conjuntivite Alérgica/tratamento farmacológico , Conjuntivite Alérgica/fisiopatologia , Difenidramina/efeitos adversos , Combinação de Medicamentos , Doenças Palpebrais/diagnóstico , Doenças Palpebrais/tratamento farmacológico , Doenças Palpebrais/etiologia , Doenças Palpebrais/fisiopatologia , Feminino , Humanos , Instilação de Medicamentos , Masculino , Azul de Metileno/efeitos adversos , Pessoa de Meia-Idade , Nafazolina/efeitos adversos , Soluções Oftálmicas , Resultado do Tratamento , Sulfato de Zinco/efeitos adversos
18.
J Chromatogr A ; 1472: 134-137, 2016 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-27773387

RESUMO

This paper reports for the first time, a method for simultaneous determination of naphazoline (NPZ) and zinc (Zn) using an analytical separation technique (capillary electrophoresis with capacitively coupled contactless conductivity detection -CE-C4D). A single run is possible every 55s (sampling rate=65h-1). The separation by CE-C4D was achieved on a fused silica capillary (50cm length - 10cm effective, 50µm i.d.) with a background electrolyte (BGE) composed by 20mmolL-1 of 2-(morpholin-4-yl)ethane-1-sulfonic acid (MES) and 20mmolL-1 of histidine (HIS) (pH 6.0). Detection limits were estimated at 20 and 30µmolL-1 and recovery values for spiked samples were 98 and 102% for NPZ and Zn, respectively. The developed procedure was compared to HPLC (NPZ) and FAAS (Zn) and no statistically significant differences were observed (95% confidence level).


Assuntos
Eletroforese Capilar/métodos , Nafazolina/análise , Zinco/análise , Cromatografia Líquida de Alta Pressão , Capacitância Elétrica , Condutividade Elétrica , Eletrólitos/química , Limite de Detecção
19.
Melanoma Res ; 26(5): 487-91, 2016 10.
Artigo em Inglês | MEDLINE | ID: mdl-27261949

RESUMO

Cutaneous squamous cell carcinoma (cSCC) is a frequent side-effect of vemurafenib treatment. The main aim of this study was to identify the clinical risk factors associated with the development of cSCC in melanoma patients treated with vemurafenib. We carried out a retrospective study, including 63 consecutive melanoma patients treated with vemurafenib for BRAF-mutant metastatic melanoma in an oncodermatological department. Clinical and follow-up data were collected and analysed, and a comparison of the subgroups who did and did not develop cSCC was performed. A total of 42.9% of patients (n=27) treated with vemurafenib developed one or more cSCC. Patients with cSCC were significantly older (P=0.01). Clear eyes were also associated with a higher risk of developing cSCC (odds ratio=3.50; 95% confidence interval: 1.08-12.43). Three patients developed cSCC more than 1 year after the initiation of treatment (12, 16 and 18 months, respectively). Clinicians should be vigilant in older patients undergoing vemurafenib therapy as well as patients with clear eyes as they seem to be at increased risk of developing cSCC, even late after the initiation of treatment.


Assuntos
Agonistas alfa-Adrenérgicos/efeitos adversos , Carcinoma de Células Escamosas/etiologia , Indóis/efeitos adversos , Melanoma/complicações , Nafazolina/efeitos adversos , Neoplasias Cutâneas/etiologia , Sulfonamidas/efeitos adversos , Fatores Etários , Carcinoma de Células Escamosas/patologia , Feminino , Humanos , Indóis/farmacologia , Masculino , Melanoma/tratamento farmacológico , Melanoma/patologia , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Neoplasias Cutâneas/patologia , Sulfonamidas/farmacologia , Vemurafenib
20.
Mol Med Rep ; 13(4): 3319-25, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26936233

RESUMO

The aim of the current study was to investigate whether olopatadine and naphazoline hydrochloride reduce allergic conjunctivitis in mice through alterations in inflammation, NGF and VEGF. An allergic conjunctivitis mouse model was established using histamine or an antigen (ovalbumin), following which mice were treated with 1% olopatadine solution and/or 0.2 mg/ml of naphazoline hydrochloride. Histamine or antigen­induced conjunctival vascular hyperpermeability was examined and the levels of inflammatory factors, cytokines, IgE, GMCSF and NGF were analyzed using ELISA in antigen­induced conjunctival vascular hyperpermeability mice. In addition, VEGF protein expression was measured using western blotting in antigen­induced mice. The results indicated that olopatadine and naphazoline hydrochloride significantly suppressed conjunctival dye leakage in mice with histamine or antigen­induced conjunctival vascular hyperpermeability. In addition, treatment with olopatadine and naphazoline hydrochloride was able to reduce the levels of inflammatory factors (TNF­α, IL­1ß and IL­6), cytokines (IFN­Î³ and IL­4), IgE, GMCSF, and NGF in antigen­induced conjunctival vascular hyperpermeability mice. The protein expression levels of VEGF in antigen­induced conjunctival vascular hyperpermeability mice were reduced following treatment with olopatadine and naphazoline hydrochloride. These results suggest that treatment with olopatadine and naphazoline hydrochloride reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF.


Assuntos
Conjuntivite Alérgica/tratamento farmacológico , Nafazolina/uso terapêutico , Fator de Crescimento Neural/metabolismo , Cloridrato de Olopatadina/uso terapêutico , Fator A de Crescimento do Endotélio Vascular/metabolismo , Animais , Western Blotting , Conjuntivite Alérgica/etiologia , Citocinas/análise , Modelos Animais de Doenças , Quimioterapia Combinada , Ensaio de Imunoadsorção Enzimática , Feminino , Fator Estimulador de Colônias de Granulócitos e Macrófagos/análise , Histamina/toxicidade , Imunoglobulina E/análise , Camundongos , Camundongos Endogâmicos BALB C , Fator de Crescimento Neural/análise , Ovalbumina/imunologia
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