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1.
J Chem Phys ; 156(17): 174202, 2022 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-35525668

RESUMO

Fluorescence-encoded infrared (FEIR) spectroscopy is a vibrational spectroscopy technique that has recently demonstrated the capability of single-molecule sensitivity in solution without near-field enhancement. This work explores the practical experimental factors that are required for successful FEIR measurements in both the single-molecule and bulk regimes. We investigate the role of resonance conditions by performing measurements on a series of coumarin fluorophores of varying electronic transition frequencies. To analyze variations in signal strength and signal to background between molecules, we introduce an FEIR brightness metric that normalizes out measurement-specific parameters. We find that the effect of the resonance condition on FEIR brightness can be reasonably well described by the electronic absorption spectrum. We discuss strategies for optimizing detection quality and sensitivity in bulk and single-molecule experiments.


Assuntos
Nanotecnologia , Vibração , Corantes Fluorescentes/química , Espectrometria de Fluorescência/métodos , Espectrofotometria Infravermelho/métodos
2.
Oxid Med Cell Longev ; 2022: 5766199, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35509832

RESUMO

Pesticides have been used in agricultural activity for decades because they represent the first defense against pathogens, harmful insects, and parasitic weeds. Conventional pesticides are commonly employed at high dosages to prevent their loss and degradation, guaranteeing effectiveness; however, this results in a large waste of resources and significant environmental pollution. In this regard, the search for biocompatible, biodegradable, and responsive materials has received greater attention in the last years to achieve the obtention of an efficient and green pesticide formulation. Nanotechnology is a useful tool to design and develop "nanopesticides" that limit pest degradation and ensure a controlled release using a lower concentration than the conventional methods. Besides different types of nanoparticles, polymeric nanocarriers represent the most promising group of nanomaterials to improve the agrochemicals' sustainability due to polymers' intrinsic properties. Polymeric nanoparticles are biocompatible, biodegradable, and suitable for chemical surface modification, making them attractive for pesticide delivery. This review summarizes the current use of synthetic and natural polymer-based nanopesticides, discussing their characteristics and their most common design shapes. Furthermore, we approached the instability phenomena in polymer-based nanopesticides and strategies to avoid it. Finally, we discussed the environmental risks and future challenges of polymeric nanopesticides to present a comprehensive analysis of this type of nanosystem.


Assuntos
Nanopartículas , Nanoestruturas , Praguicidas , Nanopartículas/química , Nanotecnologia/métodos , Polímeros
3.
Technol Cancer Res Treat ; 21: 15330338221085376, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35382635

RESUMO

Introduction: In the fight against cancer, cisplatin is most widely used as a clinical mainstay for the chemotherapy of various human cancers. Meanwhile, its cytotoxic profile, as well as drug resistance, limits its widespread application. The goal of precision medicine is to tailor an optimized therapeutic program based on the biology of the disease. Recently, nanotechnology has been demonstrated to be promising in this scenario. Objective: The current work provides a rationale for the design of an alternative oncology trial for the treatment of hepatocarcinogenesis using a novel eco-friendly nanocomplex, namely gallic acid-coated gallium nanoparticles. Moreover, the study tests whether the antineoplastic efficacy of gallic acid-coated gallium nanoparticles could be enhanced or not when it is administrated together with cisplatin. Methods: The work comprised a series of both in vitro and in vivo investigations. The in vivo therapeutic efficacy of such treatments, against diethylnitrosamine-induced hepatocarcinogenesis, was strictly evaluated by tracking target genes expressions, iron homeostasis, diverse biomarkers alterations, and lastly, routine paraclinical investigations were also assessed. Results: The in vitro biological evaluation of gallic acid-coated gallium nanoparticles in a HepG-2 cancer cell line established its superior cytotoxicity. Else more, the results of the in vivo experiment highlighted that gallic acid-coated gallium nanoparticles could diminish key hallmarks of cancer by ameliorating most of the investigated parameters. This was well-appreciated with the histopathological findings of the liver architectures of the treated groups. Conclusions: Our findings suggest that novel biogenic Ga-based nanocomplexes may potentially present new hope for the development of alternative liver cancer therapeutics, which should attract further scientific interest.


Assuntos
Antineoplásicos , Gálio , Neoplasias Hepáticas , Nanopartículas , Gálio/farmacologia , Humanos , Neoplasias Hepáticas/tratamento farmacológico , Nanotecnologia
4.
Nat Commun ; 13(1): 1996, 2022 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-35422038

RESUMO

Biolistic intracellular delivery of functional macromolecules makes use of dense microparticles which are ballistically fired onto cells with a pressurized gun. While it has been used to transfect plant cells, its application to mammalian cells has met with limited success mainly due to high toxicity. Here we present a more refined nanotechnological approach to biolistic delivery with light-triggered self-assembled nanobombs (NBs) that consist of a photothermal core particle surrounded by smaller nanoprojectiles. Upon irradiation with pulsed laser light, fast heating of the core particle results in vapor bubble formation, which propels the nanoprojectiles through the cell membrane of nearby cells. We show successful transfection of both adherent and non-adherent cells with mRNA and pDNA, outperforming electroporation as the most used physical transfection technology by a factor of 5.5-7.6 in transfection yield. With a throughput of 104-105 cells per second, biolistic delivery with NBs offers scalable and highly efficient transfections of mammalian cells.


Assuntos
Biolística , Nanotecnologia , Animais , Biolística/métodos , Substâncias Macromoleculares , Mamíferos , Células Vegetais , Transfecção
5.
Int J Pharm ; 619: 121707, 2022 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-35364218

RESUMO

Bioflavonoids are natural polyphenolic compounds derived from plant metabolites. Broadly, there are eight categories of flavonoids having multiple natural sources and pharmacological actions. Among the wide-ranging spectrum of their pharmacological actions, antioxidant, anti-inflammatory, wound healing, depigmentation, photoprotective and antiaging are beneficial to the skin and show promising actions in treating many skin ailments. However, their lipophilic nature, low solubility and poor skin penetration may cause hindrance in therapeutic actions when given by dermal route and thus, flavonoids have been converted into several nanoformulations. Among other nanotechnology-based platforms, Nanocrystal is studied widely for bioflavonoids to overcome their limitations. Nanocrystals of bioflavonoids are prepared by top-down, bottom-up or combination methods for skin delivery. This review focuses on topical nanocrystals of bioflavonoids, the effect of manufacturing methods on nanocrystal characteristics, in vitro evaluation, and animal studies for different skin ailments. Considering the multiple pharmacological actions of flavonoids, their selective targeting of skin ailments is challenging and newer in vitro models can be used for mechanistic interpretation of their therapeutic benefits. Moreover, based on adequate preclinical data, full-fledged clinical studies should be performed for bioflavonoids nanocrystals which helps in commercial translation.


Assuntos
Flavonas , Nanopartículas , Animais , Flavonoides , Nanopartículas/química , Nanotecnologia , Pele/metabolismo , Absorção Cutânea
6.
ACS Nano ; 16(4): 4981-4988, 2022 Apr 26.
Artigo em Inglês | MEDLINE | ID: mdl-35416645

RESUMO

Modern Olympics have increasingly benefited from the advancement of materials science. From February 4 to March 13, 2022, the whole world has witnessed spectacular Olympic Winter Games and Winter Paralympic Games held in Beijing, during which nanotechnologies are extensively applied and play indispensable roles in many aspects. Although these nanotechnologies appear in a very small length scale, they have provided tremendous support to all athletes with the pursuit of "faster, higher, stronger". In this Article, we highlight several representative nanotechnologies applied in the Olympic and Paralympic Winter Games including nanoscience in ice skating, wearable monitoring devices, skiing sports equipment, winter protection, and Olympic printing and discuss their physicochemical principles, unique significance for athletes and sports.


Assuntos
Esportes , Humanos , Nanotecnologia , Estações do Ano
7.
Sensors (Basel) ; 22(7)2022 Mar 24.
Artigo em Inglês | MEDLINE | ID: mdl-35408108

RESUMO

Molecular communication (MC) is a promising bioinspired paradigm for exchanging molecule information among nanomachines. In this paper, we propose a synchronization-assist photolysis MC system that aims to transmit the biosensing signal of the tumor microenvironment, facilitated by mitigating redundant molecules for improved bit error rate (BER) performance. Benefits from biocompatible MC, biosensors could transmit biosensing signals of the tumor in vivo instead of converting them to electrical signals. Due to diffusion motion's slow and stochastic nature, intersymbol interference (ISI), resulting from previous symbols' residual information molecules, inevitably occurs in diffusion-based MC. ISI is one of the challenges in diffusion-based MC, which significantly impacts signal detection. Inspired by on-off keying (OOK) modulation, the proposed modulation implements a switch of molecules and light alternatively. The light emitted is triggered by a synchronization signal, and the photolysis reactions could reduce the redundant molecules. An expression for the relevant channel impulse response (CIR) is derived from a hybrid channel model of diffusion and photolysis reaction. In this paper, we implement the maximum posterior estimation scheme to find the optimal decision threshold and analysis the BER performance in terms of different time intervals of the system. Numerical simulations demonstrate that the proposed method can improve the channel capacity and BER performance. We believe that our work may pave the way for MC application in biosensing.


Assuntos
Computadores Moleculares , Neoplasias , Comunicação , Humanos , Nanotecnologia/métodos , Neoplasias/diagnóstico , Fotólise , Microambiente Tumoral
8.
Front Immunol ; 13: 849759, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35401561

RESUMO

Chimeric antigen receptor T cell (CAR-T) therapy for the treatment of hematologic tumors has achieved remarkable success, with five CAR-T therapies approved by the United States Food and Drug Administration. However, the efficacy of CAR-T therapy against solid tumors is not satisfactory. There are three existing hurdles in CAR-T cells for solid tumors. First, the lack of a universal CAR to recognize antigens at the site of solid tumors and the compact tumor structure make it difficult for CAR-T cells to locate in solid tumors. Second, soluble inhibitors and suppressive immune cells in the tumor microenvironment can inhibit or even inactivate T cells. Third, low survival and proliferation rates of CAR-T cells in vivo significantly influence the therapeutic effect. As an emerging method, nanotechnology has a great potential to enhance cell proliferation, activate T cells, and restarting the immune response. In this review, we discuss how nanotechnology can modify CAR-T cells through variable methods to improve the therapeutic effect of solid tumors.


Assuntos
Neoplasias , Receptores de Antígenos Quiméricos , Humanos , Imunoterapia Adotiva , Nanotecnologia , Neoplasias/terapia , Microambiente Tumoral , Estados Unidos
9.
Int J Mol Sci ; 23(7)2022 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-35408937

RESUMO

A post-nanotechnology concept has been assigned to an emerging concept, nanoarchitectonics. Nanoarchitectonics aims to establish a discipline in which functional materials are fabricated from nano-scale components such as atoms, molecules, and nanomaterials using various techniques. Nanoarchitectonics opens ways to form a more unified paradigm by integrating nanotechnology with organic chemistry, supramolecular chemistry, material chemistry, microfabrication technology, and biotechnology. On the other hand, biological systems consist of rational organization of constituent molecules. Their structures have highly asymmetric and hierarchical features that allow for chained functional coordination, signal amplification, and vector-like energy and signal flow. The process of nanoarchitectonics is based on the premise of combining several different processes, which makes it easier to obtain a hierarchical structure. Therefore, nanoarchitectonics is a more suitable methodology for creating highly functional systems based on structural asymmetry and hierarchy like biosystems. The creation of functional materials by nanoarchitectonics is somewhat similar to the creation of functional systems in biological systems. It can be said that the goal of nanoarchitectonics is to create highly functional systems similar to those found in biological systems. This review article summarizes the synthesis of biomimetic and biological molecules and their functional structure formation from various viewpoints, from the molecular level to the cellular level. Several recent examples are arranged and categorized to illustrate such a trend with sections of (i) synthetic nanoarchitectonics for bio-related units, (ii) self-assembly nanoarchitectonics with bio-related units, (iii) nanoarchitectonics with nucleic acids, (iv) nanoarchitectonics with peptides, (v) nanoarchitectonics with proteins, and (vi) bio-related nanoarchitectonics in conjugation with materials.


Assuntos
Biomimética , Nanoestruturas , Biotecnologia , Nanoestruturas/química , Nanotecnologia/métodos , Peptídeos
10.
Nat Commun ; 13(1): 1842, 2022 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-35383189

RESUMO

Single-molecule fluorescence techniques have revolutionized our ability to study proteins. However, the presence of a fluorescent label can alter the protein structure and/or modify its reaction with other species. To avoid the need for a fluorescent label, the intrinsic autofluorescence of proteins in the ultraviolet offers the benefits of fluorescence techniques without introducing the labelling drawbacks. Unfortunately, the low autofluorescence brightness of proteins has greatly challenged single molecule detection so far. Here we introduce optical horn antennas, a dedicated nanophotonic platform enabling the label-free detection of single proteins in the UV. This design combines fluorescence plasmonic enhancement, efficient collection up to 85° angle and background screening. We detect the UV autofluorescence from immobilized and diffusing single proteins, and monitor protein unfolding and dissociation upon denaturation. Optical horn antennas open up a unique and promising form of fluorescence spectroscopy to investigate single proteins in their native states in real time.


Assuntos
Nanotecnologia , Proteínas , Microscopia de Fluorescência/métodos , Proteínas/química , Espectrometria de Fluorescência/métodos
11.
J Am Chem Soc ; 144(15): 6759-6769, 2022 Apr 20.
Artigo em Inglês | MEDLINE | ID: mdl-35385657

RESUMO

The overwinding and underwinding of DNA duplexes between junctions have been used in designing left- and right-handed DNA origami nanostructures, respectively. For DNA tubes obtained from self-assembled tiles, only a theoretical approach of the intrinsic curvature of the tiles has been previously used to explain their formation. Details regarding the quantitative and structural descriptions of the tile's intrinsic curvature in DNA nanostructures have so far never been addressed. In this work, we designed three types of tile cores built around a circular scaffold using three- and four-branched junctions. Joining the tile cores with arms having two kinds of inter-tile distances, an odd and an even number of DNA half-turns, tended to form planar 2D lattices and tubes, respectively. Streptavidin bound to biotin was used as a labeling technique to characterize the inside and outside surfaces of the tubes and thereby the tile conformation of dihedrals with addressable faces. DNA tubes with either right- or left-handed chirality were obtained by the coupling of the intrinsic curvature of the tiles with the arm twist. We were able to assign the chiral indices (n,m) to a tube with its structure resolved by AFM at the single-tile level and therefore to estimate the global curvature of the tube (or its component tile) using a regular polygon model that approximated its transverse section. A deeper understanding of the integrated actions of different types of twisting forces on DNA tubes will be extremely helpful in engineering more elaborate DNA nanostructures in the future.


Assuntos
Nanoestruturas , DNA/química , Microscopia de Força Atômica , Nanoestruturas/química , Nanotecnologia/métodos , Conformação de Ácido Nucleico , Pesquisa
12.
Carbohydr Polym ; 289: 119406, 2022 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-35483830

RESUMO

Mimicking the cellular machineries-based ion transport phenomenon for multipurpose applications of the nanofluidic devices has inspired scientific community. Owing to this phenomenon, various artificial nanofluidic systems are highly desirable for energy-environment associated fields including energy storage and conversion, biosensing, and desalination of seawater. Nevertheless, high cost and low efficiency hamper the development of nanofluidic devices in the respective fields. Pertinently, cellulose-based nanofluidic devices rectified the ionic transport property and offer an efficient and sustainable platform for harvesting osmotic energy. Recently, the design strategies of cellulose-based nanofluidic materials provided a more targeted material design for specific applications. Herein, we briefly introduce the structural aspects of cellulose, review the structural features and ion transport properties of cellulose-based nanofluidic materials, and highlight their applications as osmotic energy generators, sensors, transistors, flexible electronic skins, and bio-detection devices. In summary, the challenges and future perspectives of cellulose-based nanofluidic materials are described.


Assuntos
Celulose , Nanotecnologia , Transporte de Íons , Osmose
13.
J Chem Phys ; 156(16): 160903, 2022 Apr 28.
Artigo em Inglês | MEDLINE | ID: mdl-35489995

RESUMO

We review some of the progress of single-molecule optical experiments in the past 20 years and propose some perspectives for the coming years. We particularly focus on methodological advances in fluorescence, super-resolution, photothermal contrast, and interferometric scattering and briefly discuss a few of the applications. These advances have enabled the exploration of new emitters and quantum optics; the chemistry and biology of complex heterogeneous systems, nanoparticles, and plasmonics; and the detection and study of non-fluorescing and non-absorbing nano-objects. We conclude by proposing some ideas for future experiments. The field will move toward more and better signals of a broader variety of objects and toward a sharper view of the surprising complexity of the nanoscale world of single (bio-)molecules, nanoparticles, and their nano-environments.


Assuntos
Nanopartículas , Nanotecnologia , Nanopartículas/química , Nanotecnologia/métodos , Óptica e Fotônica , Análise Espectral
14.
ACS Appl Mater Interfaces ; 14(17): 19241-19252, 2022 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-35440137

RESUMO

A nanoreactor containing an evolved mutant of Saccharolobus solfataricus phosphotriesterase (L72C/Y97F/Y99F/W263V/I280T) as a catalytic bioscavenger was made for detoxification of organophosphates. This nanoreactor intended for treatment of organophosphate poisoning was studied against paraoxon (POX). Nanoreactors were low polydispersity polymersomes containing a high concentration of enzyme (20 µM). The polyethylene glycol-polypropylene sulfide membrane allowed for penetration of POX and exit of hydrolysis products. In vitro simulations under second order conditions showed that 1 µM enzyme inactivates 5 µM POX in less than 10 s. LD50-shift experiments of POX-challenged mice through intraperitoneal (i.p.) and subcutaneous (s.c.) injections showed that intravenous administration of nanoreactors (1.6 nmol enzyme) protected against 7 × LD50 i.p. in prophylaxis and 3.3 × LD50 i.p. in post-exposure treatment. For mice s.c.-challenged, LD50 shifts were more pronounced: 16.6 × LD50 in prophylaxis and 9.8 × LD50 in post-exposure treatment. Rotarod tests showed that transitory impaired neuromuscular functions of challenged mice were restored the day of experiments. No deterioration was observed in the following days and weeks. The high therapeutic index provided by prophylactic administration of enzyme nanoreactors suggests that no other drugs are needed for protection against acute POX toxicity. For post-exposure treatment, co-administration of classical drugs would certainly have beneficial effects against transient incapacitation.


Assuntos
Intoxicação por Organofosfatos , Hidrolases de Triester Fosfórico , Animais , Camundongos , Nanotecnologia , Intoxicação por Organofosfatos/tratamento farmacológico , Organofosfatos/toxicidade , Paraoxon
15.
Adv Drug Deliv Rev ; 184: 114241, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35367308

RESUMO

Two-dimensional nanomaterial-based catalytic medicines that associate the superiorities of novel catalytic mechanisms with nanotechnology have emerged as absorbing therapeutic strategies for cancer therapy. Catalytic medicines featuring high efficiency and selectivity have been widely used as effective anticancer strategies without applying traditional nonselective and highly toxic chemodrugs. Moreover, two-dimensional nanomaterials are characterized by distinctive physicochemical properties, such as a sizeable bandgap, good conductivity, fast electron transfer and photoelectrochemical activity. The introduction of two-dimensional nanomaterials into catalytic medicine provides a more effective, controllable, and precise antitumor strategy. In this review, different types of two-dimensional nanomaterial-based catalytic nanomedicines are generalized, and their catalytic theories, advanced catalytic pathways and catalytic nanosystem design are also discussed in detail. Notably, future challenges and obstacles in the design and further clinical transformation of two-dimensional nanomaterial-based catalytic nanomedicine are prospected.


Assuntos
Nanomedicina , Nanoestruturas , Catálise , Elétrons , Humanos , Nanotecnologia
16.
Eur J Pharmacol ; 923: 174934, 2022 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-35367420

RESUMO

Leishmaniasis is a neglected tropical disease that has a wide spectrum of clinical manifestations, ranging from visceral to cutaneous, with millions of new cases and thousands of deaths notified every year. The severity of the disease and its various clinical forms are determined by the species of the causative agent, Leishmania, as well as the host's immune response. Major challenges still exist in the diagnosis and treatment of leishmaniasis, and there is no vaccine available to prevent this disease in humans. Nanotechnology has emerged as a promising tool in a variety of fields. In this review, we highlight the main and most recent advances in nanomedicine to improve the diagnosis and treatment, as well as for the development of vaccines, for leishmaniasis. Nanomaterials are nanometric in size and can be produced by a variety of materials, including lipids, polymers, ceramics, and metals, with varying structures and morphologies. Nanotechnology can be used as biosensors to detect antibodies or antigens, thus improving the sensitivity and specificity of such immunological and molecular diagnostic tests. While in treatment, nanomaterials can act as drug carriers or, be used directly, to reduce any toxic effects of drug compounds to the host and to be more selective towards the parasite. Furthermore, preclinical studies show that different nanomaterials can carry different Leishmania antigens, or even act as adjuvants to improve a Th1 immune response in an attempt to produce an effective vaccine.


Assuntos
Leishmania , Leishmaniose , Vacinas , Portadores de Fármacos , Humanos , Leishmaniose/diagnóstico , Leishmaniose/tratamento farmacológico , Leishmaniose/prevenção & controle , Nanomedicina , Nanotecnologia , Vacinas/farmacologia
17.
Anal Methods ; 14(16): 1571-1578, 2022 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-35403643

RESUMO

Chemically and biologically modified substrates for single-cell patterning have been studied extensively, but physically modified structures for single-cell patterning still need further study. In this paper, physically modified silicon nanostructures were introduced to study their effect on SHSY5Y cells. Double-beam double exposure laser interference lithography combined with metal-assisted etching (MACE) was used to fabricate the physically modified silicon nanostructures. It was found that the cells on the gratings stretched and grew orderly along the grating with a small cell area and almost the same cell length compared with those on the Si wafer (control group). While on the grids, the cells were round with limited spreading, grew independently and had the smallest cell area and cell length. Moreover, the localization ratio of cells adhered onto the areas of nanopillars in the grid structures with different periods has been investigated. The results suggest that the physically modified grid silicon nanostructures can regulate the single-cell localization growth and the rational design of substrate structures can maximize the single-cell localization ratio. The findings provide guidance for the design of physically modified nanostructures and regulating single cell patterning, and a better understanding of single-cell localized growth.


Assuntos
Nanoestruturas , Silício , Luz , Nanoestruturas/química , Nanotecnologia/métodos , Impressão , Silício/química
18.
ACS Sens ; 7(4): 1045-1057, 2022 Apr 22.
Artigo em Inglês | MEDLINE | ID: mdl-35417147

RESUMO

The real-time and in situ monitoring of the synthesis of nanomaterials (NMs) remains a challenging task, which is of pivotal importance by assisting fundamental studies (e.g., synthesis kinetics and colloidal phenomena) and providing optimized quality control. In fact, the lack of reproducibility in the synthesis of NMs is a bottleneck against the translation of nanotechnologies into the market toward daily practice. Here, we address an impedimetric millifluidic sensor with data processing by machine learning (ML) as a sensing platform to monitor silica nanoparticles (SiO2NPs) over a 24 h synthesis from a single measurement. The SiO2NPs were selected as a model NM because of their extensive applications. Impressively, simple ML-fitted descriptors were capable of overcoming interferences derived from SiO2NP adsorption over the signals of polarizable Au interdigitate electrodes to assure the determination of the size and concentration of nanoparticles over synthesis while meeting the trade-off between accuracy and speed/simplicity of computation. The root-mean-square errors were calculated as ∼2.0 nm (size) and 2.6 × 1010 nanoparticles mL-1 (concentration). Further, the robustness of the ML size descriptor was successfully challenged in data obtained along independent syntheses using different devices, with the global average accuracy being 103.7 ± 1.9%. Our work advances the developments required to transform a closed flow system basically encompassing the reactional flask and an impedimetric sensor into a scalable and user-friendly platform to assess the in situ synthesis of SiO2NPs. Since the sensor presents a universal response principle, the method is expected to enable the monitoring of other NMs. Such a platform may help to pave the way for translating "sense-act" systems into practice use in nanotechnology.


Assuntos
Nanopartículas , Nanoestruturas , Nanotecnologia , Reprodutibilidade dos Testes , Dióxido de Silício
19.
Biosensors (Basel) ; 12(4)2022 Apr 07.
Artigo em Inglês | MEDLINE | ID: mdl-35448278

RESUMO

Nanotechnology has a significant impact on everything in our daily life [...].


Assuntos
Técnicas Biossensoriais , Nanoestruturas , Nanotecnologia
20.
Biosensors (Basel) ; 12(4)2022 Apr 09.
Artigo em Inglês | MEDLINE | ID: mdl-35448285

RESUMO

In SERS analysis, the specificity of molecular fingerprints is combined with potential single-molecule sensitivity so that is an attractive tool to detect molecules in trace amounts. Although several substrates have been widely used from early on, there are still some problems such as the difficulties to bind some molecules to the substrate. With the development of nanotechnology, an increasing interest has been focused on plasmonic metal nanoparticles hybridized with (2D) nanomaterials due to their unique properties. More frequently, the excellent properties of the hybrids compounds have been used to improve the drawbacks of the SERS platforms in order to create a system with outstanding properties. In this review, the physics and working principles of SERS will be provided along with the properties of differently shaped metal nanoparticles. After that, an overview on how the hybrid compounds can be engineered to obtain the SERS platform with unique properties will be given.


Assuntos
Nanopartículas Metálicas , Nanoestruturas , Ouro/química , Nanopartículas Metálicas/química , Nanoestruturas/química , Nanotecnologia , Análise Espectral Raman
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