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1.
Rev. esp. patol ; 55(4): 254-258, Oct-Dic. 2022. ilus
Artigo em Espanhol | IBECS | ID: ibc-210615

RESUMO

El hemangioendotelioma epitelioide es un tumor vascular infrecuente, descrito por primera vez en 1975 por Dail y Liebow como un carcinoma bronquioloalveolar. Habitualmente, se comporta como una neoplasia de bajo grado; sin embargo, se han descrito casos en los que el tumor manifiesta una elevada agresividad, extendiéndose con rapidez por todo el organismo. Presentamos el caso de un hombre de 41 años con dermatosis en muslo izquierdo y extensión rápida a abdomen, cuyo diagnóstico inicial fue de un carcinoma metastásico vs. linfoma. En la revisión de laminillas, se confirmó el diagnóstico de hemangioendotelioma epitelioide de piel, iniciando tratamiento con radioterapia. Este tumor afecta excepcionalmente la piel, habiéndose descrito pocos casos en la literatura médica.(AU)


Epithelioid haemangioendothelioma is a rare vascular tumor, first described in 1975 by Dail and Liebow as a bronchioloalveolar carcinoma. Although it usually behaves like a low-grade neoplasm, cases have been reported in which the tumor shows a high grade of malignancy, spreading rapidly throughout the body. We present the case of a 41-year-old man with dermatosis in the left thigh with rapid extension to the abdomen; the initial differential diagnoses were metastatic carcinoma versus lymphoma. When the histopathology was re-examined, a diagnosis of skin epithelioid hemangioendothelioma was confirmed and treatment with radiotherapy was initiated. This tumour rarely affects the skin; there are only a few previously reported cases.(AU)


Assuntos
Humanos , Masculino , Adulto , Hemangioendotelioma Epitelioide/diagnóstico , Neoplasias Cutâneas , Neoplasias de Tecido Vascular , Pacientes Internados , Exame Físico , Avaliação de Sintomas , Resultado do Tratamento , Dermatoses da Perna , Patologia , Serviço Hospitalar de Patologia , Neoplasias
2.
Pediatr Blood Cancer ; 69 Suppl 3: e29320, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-36070212

RESUMO

Vascular anomalies are a heterogeneous group of disorders that are currently classified based on their clinical and histological characteristics. Over the past decade, there have been significant advances in molecular genetics that have led to identification of genetic alterations associated with vascular tumors, vascular malformations, and syndromes. Here, we describe known genetic alterations in vascular anomalies, discuss when and how to test, and examine how identification of causative genetic mutations provides for better management of these disorders through improved understanding of their pathogenesis and increasing use of targeted therapeutic agents in order to achieve better outcomes for our patients.


Assuntos
Neoplasias de Tecido Vascular , Doenças Vasculares , Malformações Vasculares , Humanos , Mutação , Neoplasias de Tecido Vascular/genética , Malformações Vasculares/diagnóstico , Malformações Vasculares/genética , Malformações Vasculares/terapia
3.
Adv Anat Pathol ; 29(6): 389-400, 2022 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-35993506

RESUMO

Vascular neoplasms are rare tumors with a multitude of clinical presentations and behavior, which make accurate identification and subclassification challenging on limited small biopsies. Within the spectrum of these lesions, the ones with epithelioid morphology, such as epithelioid hemangioendothelioma and epithelioid angiosarcoma, are particularly challenging given the morphologic overlap with nonvascular lesions and the limited cells due to hemodilution on sampling. Herein, we review the differential diagnosis of epithelioid vascular neoplasms, with a focus on the cytomorphology, differential diagnoses, and ancillary studies that pathologists should be aware of when evaluating small biopsies and aspirates, including novel translocations, and associated monoclonal immunohistochemistry antibodies, that can help in the diagnosis of some of these tumors. Awareness of these morphologic and ancillary study findings in these rare tumors will hopefully allow pathologists to recognize and render-specific diagnoses on limited samples of these challenging lesions.


Assuntos
Hemangioendotelioma Epitelioide , Neoplasias de Tecido Vascular , Neoplasias Vasculares , Humanos , Adulto , Criança , Diagnóstico Diferencial , Neoplasias Vasculares/diagnóstico , Hemangioendotelioma Epitelioide/diagnóstico , Hemangioendotelioma Epitelioide/patologia , Imuno-Histoquímica , Biópsia
5.
Nat Commun ; 13(1): 3815, 2022 07 02.
Artigo em Inglês | MEDLINE | ID: mdl-35780137

RESUMO

It is highly important and challenging to develop donor-acceptor-donor structured small-molecule second near-infrared window (NIR-II) dyes with excellent properties such as water-solubility and chem/photostability. Here, we discovery an electron acceptor, 6,7-di(thiophen-2-yl)-[1,2,5]thiadiazolo[3,4-g]quinoxaline (TQT) with highest stability in alkaline conditions, compared with conventional NIR-II building block benzobisthiadiazole (BBT) and 6,7-diphenyl-[1,2,5] thiadiazolo[3,4-g]quinoxaline (PTQ). The sulfonated hydrophilic dye, FT-TQT, is further synthesized with 2.13-fold increased quantum yield than its counterpart FT-BBT with BBT as acceptor. FT-TQT complexed with FBS is also prepared and displays a 16-fold increase in fluorescence intensity compared to FT-TQT alone. It demonstrates real-time cerebral and tumor vessel imaging capability with µm-scale resolution. Dynamic monitoring of tumor vascular disruption after drug treatment is achieved by NIR-II fluorescent imaging. Overall, TQT is an efficient electron acceptor for designing innovative NIR-II dyes. The acceptor engineering strategy provides a promising approach to design next generation of NIR-II fluorophores which open new biomedical applications.


Assuntos
Engenharia , Neoplasias de Tecido Vascular , Corantes Fluorescentes , Humanos , Ionóforos , Oxidantes , Quinoxalinas
6.
BMJ Case Rep ; 15(6)2022 Jun 20.
Artigo em Inglês | MEDLINE | ID: mdl-35725286

RESUMO

Spindle cell haemangioma (SCH) is a slow growing, benign vascular lesion with a preference for the distal extremities. Its occurrence in the oral cavity is rare. Clinically, it presents as solitary or multiple subcutaneous nodules, therefore, it could be considered in the differential diagnosis of benign soft tissue tumours. Microscopically it mimics some malignant vascular tumours and it is necessary to differentiate it from other malignant vascular lesions. We report a case of SCH in anterior mandibular region of a young male in his 20s. Although it is a benign lesion, the reported case displayed extensive areas of muscle infiltration and necrosis. After studying the radiographic findings and considering the absence of cellular atypia, a final diagnosis of SCH was made. Literature survey suggests that this is the eleventh case of SCH reported in oral cavity.


Assuntos
Hemangioma , Neoplasias de Tecido Vascular , Neoplasias de Tecidos Moles , Diagnóstico Diferencial , Hemangioma/diagnóstico por imagem , Hemangioma/cirurgia , Humanos , Masculino , Boca/patologia , Neoplasias de Tecidos Moles/patologia
7.
BMJ Case Rep ; 15(3)2022 Mar 29.
Artigo em Inglês | MEDLINE | ID: mdl-35351763

RESUMO

Among liver vascular tumours, hepatic small vessel neoplasm (HSVN) has been recently identified as a rare infiltrative vascular neoplasm whose malignant potential is yet to be fully ascertained. About 30 cases of HSVN have been described so far. The most common clinical presentation is an asymptomatic solitary liver lesion. Multifocal disease has been described in literature; however, to date, there are no reports of disease dissemination to other organs. Here we report a case of multifocal HSVN with synchronous spleen secondary lesions.


Assuntos
Neoplasias Hepáticas , Neoplasias de Tecido Vascular , Neoplasias Vasculares , Humanos , Neoplasias Hepáticas/diagnóstico por imagem , Neoplasias Hepáticas/patologia , Baço/diagnóstico por imagem , Baço/patologia , Neoplasias Vasculares/patologia
8.
Ann Thorac Surg ; 114(6): e443-e445, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-35231429

RESUMO

Primary pulmonary artery sarcoma is an uncommon neoplasm. Given its clinical and radiographic resemblance to pulmonary embolism, initial diagnostic steps may be complicated, leading to delay in diagnosis. This report presents the case of a 52-year-old-woman who was admitted with pulmonary embolism. She underwent pulmonary embolectomy, and histopathologic examination revealed synovial sarcoma.


Assuntos
Neoplasias Pulmonares , Neoplasias de Tecido Vascular , Embolia Pulmonar , Sarcoma Sinovial , Sarcoma , Feminino , Humanos , Pessoa de Meia-Idade , Artéria Pulmonar/diagnóstico por imagem , Artéria Pulmonar/cirurgia , Artéria Pulmonar/patologia , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/cirurgia , Sarcoma/cirurgia , Embolia Pulmonar/diagnóstico , Embolia Pulmonar/etiologia , Embolia Pulmonar/cirurgia , Embolectomia/efeitos adversos , Neoplasias de Tecido Vascular/cirurgia , Neoplasias Pulmonares/patologia
9.
BMJ Case Rep ; 15(2)2022 Feb 09.
Artigo em Inglês | MEDLINE | ID: mdl-35140097

RESUMO

Two unrelated neonates were born with a large purplish congenital mass of the thigh and forearm. Both showed signs of heart dysfunction, and one of them had anaemia and thrombocytopenia. The imaging assessment of the lesions showed well-defined subcutaneous solid masses with an exuberant vascular component. Both were kept under surveillance and maintenance therapy. A progressive dimensional reduction of the lesions supported the diagnosis of rapidly involuting congenital haemangioma (RICH). RICH is a rare vascular tumour that presents as a congenital purplish bulky mass. The diagnosis depends on the clinical evaluation of the lesion and the imaging characterisation of its solid components and vascular network. RICH may be complicated by high-output heart failure, anaemia and thrombocytopenia. Despite its exuberant presentation, it undergoes involution in the first year of life; therefore, early invasive therapies should be avoided. It is essential to detect any dimensional increase, suggesting more aggressive diagnoses, such as kaposiform haemangioendothelioma.


Assuntos
Hemangioendotelioma , Hemangioma , Síndrome de Kasabach-Merritt , Neoplasias de Tecido Vascular , Sarcoma de Kaposi , Hemangioma/diagnóstico por imagem , Hemangioma/terapia , Humanos , Recém-Nascido
11.
Ann Thorac Surg ; 114(5): e375-e378, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-35051392

RESUMO

Primary pulmonary artery sarcomas are rare tumors and are commonly misdiagnosed as pulmonary embolism. Primary pulmonary sarcomas demonstrate intraluminal growth into the vessel, rather than through the wall; require complete resection to enhance survival; and require complex surgical planning. The purpose of this case report is to describe an optimal team approach with multidisciplinary planning facilitated by a customized 3-dimensional model to guide intervention and enhance communication.


Assuntos
Neoplasias Pulmonares , Neoplasias de Tecido Vascular , Sarcoma , Neoplasias Vasculares , Humanos , Artéria Pulmonar/diagnóstico por imagem , Artéria Pulmonar/cirurgia , Artéria Pulmonar/patologia , Sarcoma/diagnóstico por imagem , Sarcoma/cirurgia , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/cirurgia , Neoplasias Pulmonares/patologia , Impressão Tridimensional , Neoplasias Vasculares/diagnóstico por imagem , Neoplasias Vasculares/cirurgia
12.
Ann Thorac Surg ; 113(5): e331-e334, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-34283958

RESUMO

Primary pulmonary artery sarcoma is a rare disease with poor prognosis. Radical resection provides the best curative chances. Our 60-year old male patient underwent pulmonary artery sarcoma excision with pericardial patch repair of the main pulmonary artery in 2017, but required reoperation in 2019 due to recurrence. Total pulmonary artery bifurcation replacement was performed using a handmade 2-limbed bovine pericardial tube graft. This technique is safe and reproducible, and may offer a valuable alternative surgical strategy for this patient cohort. Our patient is still alive 4 years after initial presentation.


Assuntos
Neoplasias Pulmonares , Neoplasias de Tecido Vascular , Sarcoma , Neoplasias Vasculares , Animais , Bovinos , Humanos , Masculino , Pessoa de Meia-Idade , Artéria Pulmonar/diagnóstico por imagem , Artéria Pulmonar/cirurgia , Sarcoma/cirurgia , Neoplasias Vasculares/cirurgia
13.
Pathology ; 54(2): 225-235, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34965900

RESUMO

Histological examination of liver biopsies and resection specimens remains the gold standard to establish a definitive diagnosis of liver lesions. While hepatocellular carcinoma remains the most commonly encountered liver lesion on mass-directed biopsies, surgical pathologists must be aware of other entities that may pose diagnostic challenges, as an accurate diagnosis is key for patient management. Mesenchymal tumours of the liver are relatively uncommon, therefore many pathologists are unfamiliar with these tumours. While the clinical presentation and radiological features of these lesions often overlap, careful attention to histological clues can assist in weeding out various congeners to arrive at the most accurate diagnosis. An additional challenge when diagnosing mesenchymal tumours is the specimen type, as mass-directed core biopsies are limited and have become standard clinical practice. Besides careful attention to histological features, radiological findings and clinical history, immunohistochemical analysis and molecular studies have become of immense diagnostic value. In this review, we discuss several common and rare mesenchymal hepatic lesions as defined in the current World Health Organization (WHO) classification and most up-to-date literature. We also discuss immunohistochemistry panels and relevant molecular findings that may assist in rendering an accurate diagnosis when encountering these lesions in daily practice.


Assuntos
Angiomiolipoma/patologia , Hamartoma/patologia , Neoplasias Hepáticas/patologia , Neoplasias Epiteliais e Glandulares/patologia , Neoplasias de Tecido Muscular/patologia , Neoplasias de Tecido Vascular/patologia , Sarcoma/patologia , Angiomiolipoma/diagnóstico , Angiomiolipoma/metabolismo , Biomarcadores Tumorais/metabolismo , Biópsia , Diagnóstico Diferencial , Hamartoma/diagnóstico , Hamartoma/metabolismo , Humanos , Imuno-Histoquímica , Fígado/metabolismo , Fígado/patologia , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/metabolismo , Neoplasias Epiteliais e Glandulares/diagnóstico , Neoplasias Epiteliais e Glandulares/metabolismo , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias de Tecido Muscular/metabolismo , Neoplasias de Tecido Vascular/diagnóstico , Neoplasias de Tecido Vascular/metabolismo , Sarcoma/diagnóstico , Sarcoma/metabolismo
14.
Surg Pathol Clin ; 14(4): 645-663, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34742485

RESUMO

Vascular tumors of bone can be diagnostically challenging because of their rarity and histologic overlap with diverse mimics. Vascular tumors of bone can be categorized as benign (hemangioma), intermediate-locally aggressive (epithelioid hemangioma), intermediate-rarely metastasizing (pseudomyogenic hemangioendothelioma), and malignant (epithelioid hemangioendothelioma and angiosarcoma). Recurrent genetic alterations have been described, such as FOSB rearrangements in pseudomyogenic hemangioendothelioma and a subset of epithelioid hemangiomas; CAMTA1 or TFE3 rearrangements in epithelioid hemangioendothelioma. This review discusses the clinical, histologic, and molecular features of vascular tumors of bone, along with diagnostic pitfalls and strategies for avoidance.


Assuntos
Hemangioendotelioma Epitelioide , Hemangiossarcoma , Neoplasias de Tecido Vascular , Sarcoma , Neoplasias Vasculares , Adulto , Criança , Hemangioendotelioma Epitelioide/diagnóstico , Hemangioendotelioma Epitelioide/genética , Humanos , Neoplasias Vasculares/diagnóstico
15.
Nat Commun ; 12(1): 6011, 2021 10 14.
Artigo em Inglês | MEDLINE | ID: mdl-34650057

RESUMO

Defective pericyte-endothelial cell interaction in tumors leads to a chaotic, poorly organized and dysfunctional vasculature. However, the underlying mechanism behind this is poorly studied. Herein, we develop a method that combines magnetic beads and flow cytometry cell sorting to isolate pericytes from tumors and normal adjacent tissues from patients with non-small cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Pericytes from tumors show defective blood vessel supporting functions when comparing to those obtained from normal tissues. Mechanistically, combined proteomics and metabolic flux analysis reveals elevated hexokinase 2(HK2)-driven glycolysis in tumor pericytes, which up-regulates their ROCK2-MLC2 mediated contractility leading to impaired blood vessel supporting function. Clinically, high percentage of HK2 positive pericytes in blood vessels correlates with poor patient overall survival in NSCLC and HCC. Administration of a HK2 inhibitor induces pericyte-MLC2 driven tumor vasculature remodeling leading to enhanced drug delivery and efficacy against tumor growth. Overall, these data suggest that glycolysis in tumor pericytes regulates their blood vessel supporting role.


Assuntos
Vasos Sanguíneos/anormalidades , Glicólise , Hexoquinase/metabolismo , Neoplasias de Tecido Vascular/metabolismo , Pericitos/metabolismo , Células A549 , Animais , Vasos Sanguíneos/metabolismo , Vasos Sanguíneos/patologia , Miosinas Cardíacas/genética , Miosinas Cardíacas/metabolismo , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Células Endoteliais/metabolismo , Regulação Neoplásica da Expressão Gênica , Hexoquinase/genética , Humanos , Camundongos , Camundongos Endogâmicos C57BL , Cadeias Leves de Miosina/genética , Cadeias Leves de Miosina/metabolismo , Neoplasias/metabolismo , Neoplasias de Tecido Vascular/tratamento farmacológico , Neoplasias de Tecido Vascular/genética , Neoplasias de Tecido Vascular/patologia , Microambiente Tumoral/fisiologia , Regulação para Cima , Quinases Associadas a rho
16.
Aging (Albany NY) ; 13(16): 20609-20628, 2021 08 26.
Artigo em Inglês | MEDLINE | ID: mdl-34438367

RESUMO

BACKGROUND: Stage III colorectal cancer (CRC) patients experience varying degrees of prognosis even if receiving standard therapeutic regimes. Intravascular emboli (IVE), a type of vascular invasion, impacts the clinical outcome in CRC. In this study, we confirmed the role of IVE in predicting the prognosis of stage III CRC patients and characterized the tumor microenvironment (TME) of CRC with IVE. METHODS: Data from 220 consecutive patients (cohort 1) with stage III CRC undergoing radical surgery was collected retrospectively between January 2009 to December 2014. According to the presence of IVE, which was confirmed by two independent pathologists, patients were classified into two groups. Univariate and multivariate Cox regression analyses were performed to evaluate the relation of IVE presence to patients' prognosis. The association between IVE and clinicopathological factors was also analyzed. Furthermore, differentially expressed genes (DEGs) and gene set enrichment analyses (GSEA) were performed to describe features of the TME based on microarray data consisting of 6 patients. Tumor tissues from a separate cohort of 73 patients with stage III CRC (cohort 2) collected between June 2014 and December 2015 were used to analyze tumor-infiltrating lymphocyte (TIL) by immunohistochemistry (IHC) staining. RESULTS: IVE was observed in 126 (57.3%) patients and could serve as an unfavorable independent prognostic predictor (P < 0.001) as well as lymph node metastasis (P < 0.05) and tumor location (P < 0.05). Additionally, patients with IVE had a higher neutrophil percentage (P = 0.002) and lower lymphocyte percentage (P = 0.002) relative to those without IVE. CRC with IVE had a significantly different profile of DEGs compared to CRC without IVE, and GSEA showed chronic inflammatory and immunosuppressive TME may promote IVE development. In cohort 2, tumors with IVE had fewer CD3+ TILs in the stromal region, as well as fewer CD8+ TILs in both stromal and tumoral regions relative to those without IVE. CONCLUSION: IVE, which was related closely to a chronic inflammatory and immunosuppressive TME, forecasted a worse prognosis of stage III CRC patients and may be taken into consideration when a therapeutic strategy is decided upon.


Assuntos
Neoplasias Colorretais/imunologia , Neoplasias Colorretais/patologia , Neoplasias de Tecido Vascular/secundário , Microambiente Tumoral , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Vasos Sanguíneos/patologia , Neoplasias Colorretais/mortalidade , Feminino , Humanos , Terapia de Imunossupressão , Linfócitos/imunologia , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Estadiamento de Neoplasias , Neoplasias de Tecido Vascular/patologia , Células Neoplásicas Circulantes , Neutrófilos/imunologia , Prognóstico , Estudos Retrospectivos , Adulto Jovem
17.
Genes Chromosomes Cancer ; 60(11): 762-771, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34310785

RESUMO

An increasing number of epithelioid vascular lesions, in particular tumors from the benign and low-grade end of the spectrum, have been characterized by recurrent gene fusions. As a result, the detection of these molecular markers have improved the classification of diagnostically challenging cases. However, despite the significant progress, there are occasional lesions that do not fit in known histologic or molecular groups. Herein, we present five such unclassified epithelioid vascular lesions, which occurred in the bone and showed a distinct morphology composed of alternating vasoformative and solid growth and mild to moderate nuclear pleomorphism. The variegated morphologic appearance resembled that of composite hemangioendothelioma, being distinct from both epithelioid hemangioma and epithelioid hemangioendothelioma, and consistently showed cytologic atypia. Due to their unusual morphologic appearance and negative molecular work-up, targeted transcriptome sequencing was performed in two cases showing the presence of NFATC2 fusions with either EWSR1 or FUS genes. Three additional bone tumors with EWSR1 gene rearrangements were identified by FISH screening of a large cohort of 45 fusion-negative epithelioid vascular neoplasms, one fused to NFATC2 while two others to NFATC1. There were three females and two males, with a wide age range at presentation, mean of 44 years. The lesions occurred in the pelvis, maxillary sinus, and humerus. Two patients presented with polyostotic disease, both located in the pelvic bones. Two patients had available follow-up, one developed two local recurrences in the humerus over a 15-year period, while the other showed no recurrence 4 years subsequent to an en-bloc resection. Tumors were positive for CD31 and ERG, while negative for EMA, CK, synaptophysin, and chromogranin. FISH confirmed this abnormality in all cases, none of them being associated with gene amplifications. Further studies are needed to establish the pathogenetic relationship of this rare molecular subset with other epithelioid vascular tumors and to determine its clinical behavior.


Assuntos
Neoplasias Ósseas/genética , Células Epitelioides/metabolismo , Neoplasias de Tecido Vascular/genética , Proteínas de Fusão Oncogênica/genética , Adolescente , Adulto , Idoso , Neoplasias Ósseas/metabolismo , Neoplasias Ósseas/patologia , Células Epitelioides/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Transcrição NFATC/genética , Neoplasias de Tecido Vascular/metabolismo , Neoplasias de Tecido Vascular/patologia , Proteínas de Fusão Oncogênica/metabolismo , Proteína EWS de Ligação a RNA/genética , Proteína FUS de Ligação a RNA/genética
19.
J Cutan Pathol ; 48(11): 1335-1341, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34021619

RESUMO

BACKGROUND: Gap junctions consisting of connexins (Cx) are fundamental in controlling cell proliferation, differentiation, and cell death. Cx43 is the most broadly expressed Cx in humans and is attributed an important role in skin tumor development. Its role in cutaneous vascular neoplasms is yet unknown. METHODS: Fifteen cases each of cutaneous angiosarcoma (cAS), Kaposi sarcoma (KS), and cherry hemangioma (CH) were assessed by immunohistochemistry for expression of Cx43. Expression pattern, intensity, and percentage of positively stained cells were analyzed. Solid basal cell carcinomas served as positive and healthy skin as negative controls. RESULTS: Most cases of cAS presented with a strong Cx43 staining of almost all tumor cells, whereas endothelia of KS showed medium expression and CH showed mostly weak expression. In comparison with KS or cAS, the staining intensity of CH was significantly lower (P ≤ 0.001). All tissue sections of both cAS and KS were characterized by a mostly diffuse, cytoplasmic staining pattern of the vascular endothelia. None of those showed nuclear staining. CONCLUSION: The high-to-intermediate expression of Cx43 observed in all cases of cAS and KS suggests that this Cx may play a role in the development of malignant vascular neoplasms and serve as a helpful diagnostic marker.


Assuntos
Biomarcadores Tumorais/metabolismo , Conexina 43/metabolismo , Neoplasias de Tecido Vascular/patologia , Neoplasias Cutâneas/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Citoplasma/metabolismo , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
20.
Pediatr. aten. prim ; 23(89): 87-90, ene.-mar. 2021. ilus
Artigo em Espanhol | IBECS | ID: ibc-202620

RESUMO

La hiperplasia endotelial papilar intravascular (IPEH) es una lesión vascular benigna poco frecuente que se presenta habitualmente como una neoformación subcutánea eritemato-violácea inespecífica. El estudio histopatológico, necesario para el diagnóstico de confirmación, muestra proliferación papilar de células endoteliales asociada con material trombótico. La IPEH puede simular otras lesiones como el angiosarcoma, por lo que el diagnóstico correcto de esta entidad es esencial para evitar tratamientos agresivos. La resección con márgenes amplios suele ser suficiente


Intravascular papillary endothelial hyperplasia (IPEH) is a rare benign vascular lesion that usually presents as a nonspecific erythematous-violaceous subcutaneous neoformation. The histopathological study, necessary for the confirmatory diagnosis, shows papillary proliferation of endothelial cells associated with thrombotic material. IPEH can simulate other lesions such as angiosarcoma, so the correct diagnosis of this entity is essential to avoid aggressive treatments. The resection with wide margins is usually enough


Assuntos
Humanos , Masculino , Criança , Hiperplasia/diagnóstico , Hiperplasia/patologia , Neoplasias Vasculares/diagnóstico , Neoplasias de Tecido Vascular/patologia , Dermatopatias/patologia , Endotélio Vascular/patologia , Hiperplasia/cirurgia , Neoplasias Vasculares/patologia , Proliferação de Células , Manobra de Valsalva/fisiologia , Biópsia
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