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1.
Nutrients ; 13(6)2021 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-34072740

RESUMO

This study aims to quantify concentrations of minerals and trace elements in human milk (HM) and infant formula (IF) and evaluate associations with medical, social, environmental, and demographic variables. A prospective, case series study of 170 nursing mothers was made. HM samples were obtained from full-term (colostrum, intermediate and mature HM) and preterm (mature HM) mothers. Variables of interest were assessed by a questionnaire. For comparison, IF samples (n = 30) were analyzed in a cross-sectional study. Concentrations of 35 minerals, essential and toxic trace elements were quantified, 5 for the first time: thallium in HM and IF; strontium in preterm HM; and gallium, lithium and uranium in IF. In preterm and full-term HM, levels of selenium (p < 0.001) were significantly lower than recommended and were associated with low birth weight (p < 0.002). Cesium and strontium concentrations were significantly higher than recommended (p < 0.001). Associations were observed between arsenic and residence in an urban area (p = 0.013), and between lead and smoking (p = 0.024) and well-water consumption (p = 0.046). In IF, aluminum, vanadium, and uranium levels were higher than in HM (p < 0.001); uranium, quantified for the first time, was 100 times higher in all types of IF than in HM. Our results indicate that concentrations of most trace elements were within internationally accepted ranges for HM and IF. However, preterm infants are at increased risk of nutritional deficiencies and toxicity. IF manufacturers should reduce the content of toxic trace elements.


Assuntos
Leite Humano/química , Minerais/análise , Gravidez/estatística & dados numéricos , Oligoelementos/análise , Adulto , Estudos Transversais , Feminino , Humanos , Fórmulas Infantis/química , Recém-Nascido , Noxas/análise , Nascimento Prematuro/epidemiologia , Fatores Socioeconômicos , Espanha , Adulto Jovem
2.
Ann Neurol ; 89(3): 444-458, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33219556

RESUMO

OBJECTIVE: It is unclear if stopping treatment with dabigatran, a new oral anticoagulant (NOAC), induces a paradoxical rebound prothrombotic state. We investigated if short-term (1-3 days) dabigatran cessation is associated with a higher thrombus volume than expected from a simple reversal of the anticoagulant effect. METHODS: Ten-week-old C57Bl/6 mice (n = 338) received one of the following oral treatments: phosphate-buffered saline (PBS), dabigatran for 7 days with or without 1 to 4 day cessation, and aspirin in either a single dose or daily for 7 days. Some of the animals that ceased dabigatran for 1 to 3 days received single-dose aspirin. Thereafter, we induced FeCl3 -mediated carotid thrombosis in 130 mice, after which we performed micro computed tomography thrombus imaging. The other 208 mice underwent coagulation assays or platelet function tests. As an explorative pilot study, we reviewed the medical records of 18 consecutive patients with NOAC cessation-related cerebral infarction in a large acute stroke cohort. RESULTS: We observed a ~ 40% higher volume of carotid thrombus after dabigatran cessation at 1 to 3 days than after vehicle treatment and showed that this effect could be prevented by single-dose aspirin pretreatment. Dabigatran cessation unduly increased platelet aggregability for 2 days after drug cessation, an effect mediated through thrombin or arachidonic acid, which effect was significantly attenuated by single-dose aspirin pretreatment. In patients, short-term (≤ 3 days) cessation of NOAC therapy, compared with longer-term (≥ 5 days) cessation, tended to be associated with relatively high stroke severity. INTERPRETATION: We provide the first preclinical evidence that a rebound prothrombotic state follows short-term cessation of dabigatran therapy. ANN NEUROL 2021;89:444-458.


Assuntos
Antitrombinas/efeitos adversos , Trombose das Artérias Carótidas/diagnóstico por imagem , Dabigatrana/efeitos adversos , Desprescrições , Agregação Plaquetária/efeitos dos fármacos , Síndrome de Abstinência a Substâncias/sangue , Trombofilia/sangue , Idoso , Idoso de 80 Anos ou mais , Animais , Antitrombinas/farmacologia , Ácido Araquidônico/sangue , Aspirina/farmacologia , Trombose das Artérias Carótidas/induzido quimicamente , Trombose das Artérias Carótidas/prevenção & controle , Infarto Cerebral/diagnóstico por imagem , Infarto Cerebral/etiologia , Infarto Cerebral/fisiopatologia , Infarto Cerebral/prevenção & controle , Cloretos/toxicidade , Angiografia por Tomografia Computadorizada , Dabigatrana/farmacologia , Inibidores do Fator Xa/efeitos adversos , Feminino , Compostos Férricos/toxicidade , Humanos , AVC Isquêmico/diagnóstico por imagem , AVC Isquêmico/etiologia , AVC Isquêmico/fisiopatologia , AVC Isquêmico/prevenção & controle , Angiografia por Ressonância Magnética , Masculino , Volume Plaquetário Médio , Camundongos , Noxas/toxicidade , Projetos Piloto , Inibidores da Agregação Plaquetária/farmacologia , Contagem de Plaquetas , Pirazóis/efeitos adversos , Piridonas/efeitos adversos , Rivaroxabana/efeitos adversos , Índice de Gravidade de Doença , Síndrome de Abstinência a Substâncias/etiologia , Síndrome de Abstinência a Substâncias/prevenção & controle , Trombina/metabolismo , Trombofilia/etiologia , Trombofilia/prevenção & controle , Microtomografia por Raio-X
4.
Med. interna (Caracas) ; 37(1): 13-20, 2021. ilus, tab
Artigo em Espanhol | LILACS, LIVECS | ID: biblio-1253882

RESUMO

Las enfermedades infecciosas que comprometen el aparato respiratorio, generalmente son más graves en las gestantes y en las puérperas en comparación con las no embarazadas. Dentro de estas infecciones, se encuentran las producidas por agentes virales como la influenza estacional, pandémica y zoonótica, los coronavirus SARS, el MERS; y desde el año 2019 el SARS-CoV-2 causante de la actual pandemia COVID-19. Las noxas virales pueden ejercer un efecto deletéreo sobre el feto debido a respuesta inflamatoria vía cascada de citoquinas o daño directo a nivel de algunos tejidos. Los efectos del SARS-CoV-2 a nivel placentario, no están bien entendidos, los hallazgos histopatológicos incluyen alteraciones de la perfusión venosa materna y fetal y signos de inflamación placentaria en diferentes porcentajes. La placenta es un órgano altamente especializado que confiere una protección especial generando un ambiente protegido manteniendo un equilibrio de factores inmunes y bioquímicos que favorecen el desarrollo fetal. Su estructura funciona como una barrera protectora dificultando o impidiendo el paso de noxas al producto de la gestación. Diversos patógenos, incluyendo los virus pueden alterar los diferentes componentes celulares de la placenta. En la siguiente revisión describimos los más recientes hallazgos de la interacción con la placenta de diversos virus respiratorios y sus consecuencias en la salud materno fetal(AU)


Infectious diseases of the respiratory system generally present greater severity in women during pregnancy or puerperium, than in non-pregnant women. Among them, we find those produced by viral agents such as seasonal, pandemic and zoonotic influenza, SARS coronaviruses, MERS; and since 2019 the SARS-CoV-2, the cause of the current COVID-19 pandemic. Viral noxae can exert a deleterious effect on the fetus due to an inflammatory response via the cytokines cascade or direct damage at some tissues. The effects of SARS-CoV-2 on the placenta is not well understood, the histopathological findings include alterations of maternal and fetal perfusion and signs of placental inflammation in different degrees. The placenta is a highly specialized organ that confers a special protection by generating a protected environment maintaining a balance of immune and biochemical factors that favor the fetal development. Its structure works as a protective barrier, hindering or preventing the passage of noxae to the fetus. Several pathogens, including viruses, can alter different cellular components of the placenta. In the review, we describe the most recent findings of the interaction of various respiratory viruses with the placenta and their consequences on maternal and fetal health(AU)


Assuntos
Humanos , Feminino , Gravidez , Infecção Puerperal , Doenças Respiratórias/fisiopatologia , Doenças Transmissíveis , Gestantes , Vírus , Influenza Humana , COVID-19 , Noxas
5.
Revista Digital de Postgrado ; 9(2): 214, ago. 2020.
Artigo em Espanhol | LILACS, LIVECS | ID: biblio-1103446

RESUMO

El término Origen Temprano de las Enfermedades del Adulto explica la aparición temprana de las condiciones anormales cardiovasculares y metabólicas en la vida adulta, mayor riesgo de morbilidad y muerte asociados a factores ambientales, especialmente nutricionales, que actúan en las primeras etapas de la vida. Estas respuestas programadas dependen de la naturaleza del estímulo o noxa, del tiempo de exposición y del momento de ocurrencia de la noxa, pudiendo un solo genotipo original varios fenotipos y estarían condicionadas por criterios críticos en los cuales se desarrollarían cambios a largo plazo pudiendo ser reversibles o no. La Programación Fetal explica que respuestas adaptativas embrionarias y fetales en un ambiente subóptimo genera consecuencias adversas permanentes. La desnutrición, así como la sobrenutrición fetal aumenta el riesgo de desarrollar alteraciones en el peso y composición corporal fetal, y posteriormente obesidad, síndrome metabólico, incremento en la adiposidad, alteración en el metabolismo de la glucosa y / o insulina, alteración del metabolismo lipídico, alteraciones hepáticas y de las cifras tensionales. La impronta genómica es esencial para el desarrollo y defectos en la misma puede originar alteraciones de la identidad parental transmisibles a las siguientes generaciones. Esta programación fetal puede ser explicada por la epigenética, definida como la serie de alteraciones hereditarias de la expresión genética a través de modificaciones del ADN y las histonas centrales sin cambios en la secuencia de ADN. Estas modificaciones epigenéticas alteran la estructura y condensación de la cromatina, afectando la expresión del genotipo y fenotipo. Este artículo desarrolla los aspectos involucrados en la Programación Fetal y los posibles mecanismos sobre la misma(AU)


The term Early Origin of Adult Diseases explains the early onset of abnormal cardiovascular and metabolic conditions in adult life, increased risk of morbidity and death associated with environmental factors, especially nutritional factors, that act in the early stages of life. These programmed responses depend on the nature of the stimulus or noxa, the time of exposure and the moment of occurrence of the noxa, with a single original genotype being able to have several phenotypes and would be conditioned by critical criteria in which long-term changes could develop, reversibles or not. Fetal Programming explains that embryonic and fetal adaptive responses in a suboptimal environment generate permanent adverse consequences. Fetal malnutrition as overnutrition increases the risk of developing alterations in fetal body weight and composition, and subsequently obesity, metabolic syndrome, increased adiposity, impaired glucose and / or insulin metabolism, impaired lipid metabolism, liver disorders and altered blood pressure. The genomic imprint is essential for development and defects in it can cause alterations of the parental identity and are transmitted to the following generations. This fetal programming can be explained by epigenetics, defined as the series of inherited alterations of genetic expression through modifications of DNA and central histones without changes in the DNA sequence. These epigenetic modifications alter the structure and condensation of chromatin, affecting the expression of the genotype and phenotype. This article develops the aspects involved in Fetal Programming and the possible mechanisms on it(AU)


Assuntos
Humanos , Transtornos da Nutrição Fetal , Desenvolvimento Fetal , Noxas , Doenças Nutricionais e Metabólicas , Composição Corporal , Hipotálamo/anatomia & histologia , Erros Inatos do Metabolismo
6.
Infectio ; 24(2): 93-97, abr.-jun. 2020. tab, graf
Artigo em Inglês | LILACS, COLNAL | ID: biblio-1114847

RESUMO

Abstract Introduction: The tourniquet used in venipuncture appears as a potential vehicle for the transmission of microorganisms that interferes with safety and the quality of clinical services. Objective: Mapping the scientific evidence on the microbiological contamination of the tourniquets used in peripheral venipuncture. Methodology: Scoping review following the Joanna Briggs Institute methodology. Results: 20 studies have been included, in which of 1477 tourniquets were analyzed. The rates of microbiological contamination varied between 10-100% and 19 studies reported the presence of S. aureus, 11 of them detected methicillin-resistant strains with prevalence between 3.3-58.3%. Conclusion: The contamination rate in the majority of studies was ≥70%, including 4 studies which had sampled ≥100 tourniquets. The evidence of our study is that the tourniquets are reservoirs of potential pathogens and can be transmitted to patient on staff hands. We recommend studies that confirm the reusable tourniquets can be responsible to healthcare associated infections.


Resumen Introducción: El torniquete utilizado en la venopunción aparece como potencial vehículo para transmisión de microorganismos que entorpece la seguridad y calidad de los servicios clínicos. Objetivo: Mapear pruebas científicas sobre contaminación microbiológica de los torniquetes utilizados en la venopunción periférica. Metodología: Revisión de acuerdo con la metodología del Instituto Joanna Briggs. Resultados: Se han incluido 20 estudios, en los que se analizó un total de 1477 torniquetes. Las tasas de contaminación microbiológica variaron entre 10-100% y 19 estudios informaron la presencia de S. aureus, 11 detectaron cepas resistentes a meticilina con prevalencia entre 3.3-58.3%. Conclusión: La tasa de contaminación en mayoría de los estudios fue ≥70%, 4 estudios que habían muestreado ≥100 torniquetes. Nuestro estudio evidencia que los torniquetes son reservorios de patógenos y pueden transmitirse al paciente en manos del personal. Recomendamos estudios que confirmen que los torniquetes pueden ser responsables de las infecciones asociadas a la atención médica.


Assuntos
Humanos , Torniquetes , Staphylococcus aureus , Infecção Hospitalar , Anti-Infecciosos , Noxas
7.
J Neurogenet ; 34(3-4): 430-439, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32362197

RESUMO

Across animal phyla, sleep is associated with increased cellular repair, suggesting that cellular damage may be a core component of sleep pressure. In support of this notion, sleep in the nematode Caenorhabditis elegans can be triggered by damaging conditions, including noxious heat, high salt, and ultraviolet light exposure. It is not clear, however, whether this stress-induced sleep (SIS) is a direct consequence of cellular damage, or of a resulting energy deficit, or whether it is triggered simply by the sensation of noxious conditions. Here, we show that thermosensation is dispensable for heat-induced sleep, that osmosensation is dispensable for salt-induced sleep, and that wounding is also a sleep trigger, together indicating that SIS is not triggered by sensation of noxious environments. We present evidence that genetic variation in cellular repair pathways impacts sleep amount, and that SIS involves systemic monitoring of cellular damage. We show that the low-energy sensor AMP-activated protein kinase (AMPK) is not required for SIS, suggesting that energy deficit is not the primary sleep trigger. Instead, AMPK-deficient animals display enhanced SIS responses, and pharmacological activation of AMPK reduces SIS, suggesting that ATP-dependent repair of cellular damage mitigates sleep pressure.


Assuntos
Caenorhabditis elegans/fisiologia , Sono/fisiologia , Cicatrização/fisiologia , Adenilato Quinase/fisiologia , Aminoimidazol Carboxamida/análogos & derivados , Aminoimidazol Carboxamida/farmacologia , Animais , Toxinas de Bacillus thuringiensis/fisiologia , Caenorhabditis elegans/genética , Proteínas de Caenorhabditis elegans/genética , Proteínas de Caenorhabditis elegans/fisiologia , Endotoxinas/fisiologia , Ativação Enzimática , Proteínas Hemolisinas/fisiologia , Temperatura Alta , Noxas , Pressão Osmótica/fisiologia , Ribonucleotídeos/farmacologia , Sono/genética , Cloreto de Sódio/farmacologia , Estresse Fisiológico/genética , Estresse Fisiológico/fisiologia , Raios Ultravioleta , Ferimentos e Lesões/fisiopatologia
8.
Biosci. j. (Online) ; 36(3): 691-701, 01-05-2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1146440

RESUMO

The application of chemical pesticides for the control of fungal diseases results in impacts on the environment and human health. The use of vegetal extracts with antifungal properties for the proper management of crops becomes a viable alternative, mainly for organic and family farming. The objective of this study was to carry out the phytochemical evaluation of Datura inoxia, evaluating its antifungal potential against the mycelial growth of Fusarium solani and Sclerotinia sclerotiorum. The extracts, aqueous and ethanolic, obtained from the leaves of the plant collected in areas of the municipality of Campo Grande, Mato Grosso do Sul, were submitted to phytochemical prospecting and quantification of flavonoids and total phenols. It was evaluated its antifungal activity at concentrations of 800, 1200, 1600, 2000, and 2400 µg 100 mL-1. Each concentration was separately incorporated into BDA agar, poured into Petri dishes, and inoculated with the mycelial disc of the fungus. The diameter of the colonies were measured daily. Two solutions were prepared as control, one containing the solvent added to PDA medium (ethanol solution), and another with only PDA medium (without D. inoxia extract, control). In both extracts were found the same diversity of secondary metabolites (nine classes). The ethanolic extract, a solvent of lower polarity than water, was more efficient in the extraction of these constituents. Alkaloids and phenolic compounds were the most frequent compounds (100%). In relation to antifungal activity, the ethanolic extract provided 100% inhibition of mycelial growth ofSclerotinia sclerotitorum in all concentrations, relative to the control. On the other hand, the growth ofFusarium solani was only negatively affected at the highest concentrations of 800 and 1200 µmL-1 100 mL-1. The antifungal potential of Datura inoxia was probably related to the abundance of alkaloids and phenolic compounds in its chemical constitution that negatively effects the development of the vegetative mycelium.


A aplicação de defensivos químicos para o controle de doenças fúngicas tem por consequência impactos sobre o ambiente e a saúde humana. Desta forma, a utilização de extratos vegetais com propriedades antifúngicas associado ao manejo adequado de culturas, torna-se uma proposta viável de controle alternativo, principalmente na agricultura orgânica e familiar. Neste sentido, objetivou-se realizar a avaliação fitoquímica das folhas de Datura inoxia, avaliando seu potencial antifúngico frente ao crescimento micelial de Fusarium solani e Sclerotinia sclerotiorum. Os extratos, aquoso e etanólico, obtidos das folhas da planta coletadas em áreas do município de Campo Grande, Mato Grosso do Sul, foram submetidos à prospecção fitoquímica e quantificação flavonoides e fenóis totais, avaliando-se sua atividade antifúngica em concentrações de 800, 1200, 1600, 2000 e 2400 µg 100 mL-1. Cada concentração foi incorporada, separadamente, em ágar BDA, vertida em placas de petri, seguida da colocação do disco de micélio do fungo, com diâmetro das colônias sendo medido diariamente. Utilizou-se como controle negativo, ágar sem extrato e ágar com solução etanólica. Nos dois extratos ocorreu a mesma diversidade de metabólitos secundários (nove classes); porém o extrato etanólico, um solvente de menor polaridade que a água, foi mais eficiente na extração destes constituintes, com destaque aos alcaloides e compostos fenólicos com maior frequência (100%). Em relação a atividade antifúngica, o extrato etanólico proporcionou inibição de 100% do crescimento micelial de Sclerotinia sclerotitorum, em todas as concentrações, em relação a testemunha. Por outro lado, o crescimento de Fusarium solani foi afetado negativamente apenas nas maiores concentrações, 800 e 1200 µmL-1 100 mL-1.O potencial antifúngico da planta provavelmente está relacionado a sua constituição química, com abundância de alcaloides e compostos fenólicos, afetando negativamente o desenvolvimento do micélio vegetativo.


Assuntos
Solo , Extratos Vegetais , Datura metel , Fungos , Praguicidas , Doenças das Plantas , Ascomicetos , Controle , Compostos Fenólicos , Compostos Fitoquímicos , Fusarium , Noxas
9.
Turk J Med Sci ; 50(2): 448-454, 2020 04 09.
Artigo em Inglês | MEDLINE | ID: mdl-32222132

RESUMO

Background/aim: Aspartame (APM, L-aspartyl-L-phenylalanine methylester) is a low-calorie, nonsaccharide artificial sweetener widely used in foods and beverages. When metabolized by the body, APM is broken down into aspartic acid, phenylalanine amino acids, and a third substance, methanol. Since the amino acid phenylalanine serves as a neurotransmitter building block affecting the brain, and methanol is converted into toxic formaldehyde, APM has deleterious effects on the body and brain. Thus, its safety and, toxicity have been the subjects of concern ever since it was first discovered. Although many studies have been performed on it, due to the presence of conflicting data in the literature, there are still numerous question marks concerning APM.Therefore, the safety of aspartame was tested using in vitro methods. Materials and methods: We aimed to evaluate the in vitro cytotoxic effects by using 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase release tests, genotoxic damage potential by using chromosome aberration (CA) assay, and antioxidant/oxidant activity by using total antioxidant capacity (TAC) and total oxidative stress (TOS) analysis in primary human whole blood cell cultures. Results: The results of the MTT test showed that APM led to significant decreases in cell viability in a clear concentration-dependent manner. Moreover, an increase in CA frequency was found in the cells treated with APM. However, APM treatments did not cause any significant changes in TAC and TOS levels in whole blood cultures. Conclusion: Overall, the obtained results showed that APM had genotoxicity potential and a concentration-dependent cytotoxic activity in human blood cells.


Assuntos
Aspartame/toxicidade , Células Sanguíneas/efeitos dos fármacos , Noxas/toxicidade , Antioxidantes , Sobrevivência Celular/efeitos dos fármacos , Células Cultivadas , Humanos , Cariótipo , Testes de Toxicidade
10.
Rev. Inst. Adolfo Lutz ; 79(Único): 1-10, 31 mar. 2020. tab, graf
Artigo em Português | LILACS, Coleciona SUS, Sec. Est. Saúde SP, CONASS, SESSP-ACVSES, SESSP-IALPROD, Sec. Est. Saúde SP, SESSP-IALACERVO | ID: biblio-1293153

RESUMO

As esponjas de banho podem carrear contaminação, pois sua estrutura favorece a multiplicação microbiana. Desse modo, o objetivo deste trabalho foi verifica a eficiência de dois métodos de desinfecção para diminuir a quantidade de microrganismos de importância clínica nas esponjas de banho. Foram analisadas 30 esponjas de banho (15 vegetais e 15 sintéticas) que foram cortadas em três partes iguais. Uma delas serviu como controle. As demais partes foram submetidas à desinfecção por fervura durante cinco minutos e à imersão em hipoclorito de sódio 200 ppm. Os resultados demonstraram média de contaminação de bactérias heterotróficas de 4,1 LogUFC/mL e 4,7 LogUFC/mL, para as vegetais e sintéticas, respectivamente. A maioria (80%) das esponjas (10 sintéticas e 14 vegetais) apresentou contaminação por microrganismos de importância clínica. Os métodos de desinfecção reduziram as contagens de bactérias heterotróficas em 3,3 LogUFC/mL com fervura durante cinco minutos e 1,8 LogUFC/mL com desinfecção em hipoclorito de sódio 200 ppm. Conclui-se, portanto, que as esponjas de banho possuem contaminação microbiológica de importância clínica e que a fervura por cinco minutos é um método de fácil execução, baixo custo e capaz de controlar a quantidade de bactérias nas esponjas utilizadas para banho, reduzindo a disseminação de doenças. (AU)


Bath sponges can carry contamination, because their structure favors microbial multiplication. Thus, the objective of this work was to verify the efficiency of two disinfection methods to decrease the number of microorganisms of clinical importance in bath sponges. Thirty bath sponges (15 loofah and 15 synthetic) were analyzed and cut in three equal parts. One served as control. The other parts were boiled disinfected for five minutes and immersed in 200 ppm sodium hypochlorite. The results showed a mean contamination of heterotrophic bacteria of 4.1 LogUFC/mL and 4.7 LogUFC/mL, for plants and synthetic, respectively. The majority (80%) of the sponges (10 synthetic and 14 loofah) presented contamination by microorganisms of clinical importance. Disinfection methods reduced the counts of heterotrophic bacteria by 3.3 LogUFC/mL with boiling for five minutes and 1.8 LogUFC/mL with disinfection with 200 ppm sodium hypochlorite. It is concluded, therefore, that bath sponges present microbiological contamination of clinical importance and that boiling for five minutes is an easily executed low-cost method that is able to control the amount of bacteria in sponges used for bathing, reducing the risk of dissemination of disease. (AU)


Assuntos
Bactérias , Reservatórios de Doenças , Desinfecção , Luffa , Produtos para Higiene Pessoal , Noxas
11.
Biosci. j. (Online) ; 36(2): 546-555, 01-03-2020. tab, ilus
Artigo em Inglês | LILACS | ID: biblio-1146419

RESUMO

Campylobacter spp. is an emerging pathogen that causes gastroenteritis in humans and the consumption of dairy food can characterize sources of infection. We aimed to verify the viability and a presence of transcripts associated with characteristics of virulence and adaptation of C. jejuni isolated from Minas Frescal cheeses, produced with contaminated milk and stored under refrigeration for up to ten days. The samples were analyzed for bioindicators, Campylobacter spp., pH, acidity, moisture and sodium chloride. Campylobacter spp. recovered were evaluated for the production of transcripts of: ciaB, dnaJ, p19 and sodB. The results were correlated with the viability of C. jejuni and changes in their transcriptome. Storage at lowtemperatures reduced C. jejuni from the first to the fourth day. The variations in humidity, pH and acidity influenced the decreasing of C. jejuni. There was a reduction in transcripts' production of the four genes, more pronounced on the fourth day, indicating the inability of the microorganism to perform its metabolic activities, due to the conditions of injury. Despite the presence of mechanisms of virulence and adaptation, C. jejuni could not remain viable four days after production. However, consumption of fresh cheese contaminated with Campylobacter jejuni can be a source of infection when consumed up to four days after production.


Campylobacter spp. é um patógeno emergente que causa gastroenterite em seres humanos e o consumo de produtos lácteos pode caracterizar fontes de infecção. O objetivo deste estudo foi verificar a viabilidade e a presença de transcritos associadas a características de virulência e adaptação de C. jejuniisoladas de queijos frescos, produzidos com leite contaminado e mantidos refrigeradas por dez dias. Foram analisados bioindicadores, Campylobacter spp., pH, acidez, umidade e cloreto de sódio. Campylobacter spp. recuperados foram avaliados quanto à produção dos transcritos: ciaB, dnaJ, p19 e sodB. Os resultados foram correlacionados com a viabilidade de C. jejuni e alterações no transcriptoma. O armazenamento em baixas temperaturas reduziu C. jejuni do primeiro ao quarto dia. As variações na umidade, pH e acidez influenciaram a queda de C. jejuni. Houve uma redução na produção de transcritos dos quatro genes, mais pronunciada no quarto dia, indicando a incapacidade do micro-organismo em realizar suas atividades metabólicas, devido às condições de injúria. Apesar da presença de mecanismos de virulência e adaptação, C. jejuni não permaneceu viável quatro dias após a produção. Porém, o consumo de queijo fresco contaminado com Campylobacter jejunipode ser uma fonte de infecção quando consumido até quatro dias após a produção.


Assuntos
Infecções por Campylobacter , Queijo , Campylobacter jejuni , Virulência , Laticínios , Gastroenterite , Infecções , Noxas
12.
Med. U.P.B ; 39(1): 42-48, 24 de febrero de 2020. tab
Artigo em Espanhol | LILACS, COLNAL | ID: biblio-1052270

RESUMO

Los reportes de casos de microcefalia en Brasil han significado un reto para la salud pública, especialmente en países de Latinoamérica como Colombia, pues a pesar de su presunta relación con el virus Zika, se desconoce cómo los otros factores implicados en la etiología de la microcefalia se relacionan con este aumento de casos. También se cuenta con pocas estadísticas epidemiológicas acerca del comportamiento de los factores etiológicos de microcefalia hasta el año clave de 2015, no solo en Brasil sino en la mayoría de países latinoamericanos. Las estimaciones de la incidencia y prevalencia de microcefalia son variables debido a diferencias en las definiciones, estándares de seguimiento y diferencias entre las poblaciones que tienen y las que no tienen validados los estándares de diagnóstico y seguimientos de microcefalia. Se realiza una revisión con una mirada general a la microcefalia, se unifican definiciones, clasificación y etiología.


The reports of cases of microcephaly in Brazil have posed a challenge for the public health, in particular, in Latin American countries such as Colombia, since despite their alleged relationship with the Zika virus, there is no information on the relation of other factors involved in the etiology of microcephaly are related with this increase in cases. There are also very few epidemiological statistics on the behavior of the etiological factors of microcephaly until the crucial year of 2015, not only in Brazil, but also in most Latin American countries. The changes in the incidence and prevalence of microcephaly are very variable due to the dissimilarities in the definitions, the development criteria and the differences among the populations with and without certified diagnostic standards and follow-up criteria for microcephaly. A general review of the microcephaly issue is made, in order to unify definitions, classification and etiology.


Os relatórios de casos de microcefalia no Brasil há significado um desafio para a saúde pública, especialmente nos países da América Latina como a Colômbia, pois a pesar de sua suposta relação com o vírus Zika, se desconhece como os outros fatores implicados na etiologia da microcefalia se relacionam com este aumento de casos. Também se conta com poucas estadísticas epidemiológicas sobre o comportamento dos fatores etiológicos de microcefalia até o ano chave de 2015, não só no Brasil se não na maioria de países latino-americanos. As estimações da incidência e prevalência de microcefalia são variáveis devido a diferenças nas definições, padrões de seguimento e diferenças entre as populações que têm e as que não têm validados os padrões de diagnóstico e seguimentos de microcefalia. Se realiza uma revisão com uma olhada geral à microcefalia, se unificam definições, classificação e etiologia.


Assuntos
Humanos , Zika virus , Saúde Pública , Microcefalia , Noxas
13.
Mol Hum Reprod ; 26(2): 111-116, 2020 02 29.
Artigo em Inglês | MEDLINE | ID: mdl-31943113

RESUMO

An adverse outcome pathway (AOP) is a simplified description of the sequence of mechanistic events that lead to a particular toxicological effect, from initial trigger to adverse outcome. Although designed to inform regulatory risk assessors, the AOP framework also provides a platform for innovative collaborations between experts from relevant research fields and the regulatory community. The underpinning for any AOP is basic knowledge about molecular and developmental processes; such knowledge can only be attained by solid bioscientific research. Starting with this fundamental knowledge, the objective is to devise novel testing strategies that focus on key events in a causative pathway. It is anticipated that such a knowledge-based approach will ultimately alleviate many of the burdens associated with classical chemical testing strategies that typically involve large-scale animal toxicity regimens. This hails from the notion that a solid understanding of the underlying mechanisms will allow the development and use of alternative test methods, including both in vitro and in silico approaches. This review is specifically targeted at professionals working in bioscientific fields, such as developmental and reproductive biology, and aims to (i) inform on the existence of the AOP framework and (ii) encourage new cross-disciplinary collaborations. It is hoped that fundamental biological knowledge can thus be better exploited for applied purposes: firstly, an improved understanding of how our perpetual exposure to environmental chemicals is causing human reproductive disease and, secondly, new approaches to screen for harmful chemicals more efficiently. This is not an instructional manual on how to create AOPs; rather, we discuss how to harness fundamental knowledge from the biosciences to assist regulatory toxicologists in their efforts to protect humans against chemicals that harm human reproductive development and function.


Assuntos
Rotas de Resultados Adversos , Biologia do Desenvolvimento/métodos , Noxas/efeitos adversos , Reprodução/efeitos dos fármacos , Medicina Reprodutiva/métodos , Toxicologia/métodos , Canal Anal/embriologia , Androgênios/fisiologia , Animais , Disruptores Endócrinos/toxicidade , Genitália/embriologia , Humanos , Comunicação Interdisciplinar , Internet , Modelos Animais , Mamilos/embriologia , Noxas/toxicidade , Reprodução/fisiologia , Tretinoína/toxicidade
14.
J Neurosci ; 40(7): 1538-1548, 2020 02 12.
Artigo em Inglês | MEDLINE | ID: mdl-31896672

RESUMO

Our sensory impressions of pain are generally thought to represent the noxious properties of an agent but can be influenced by the predicted level of threat. Predictions can be sourced from higher-order cognitive processes, such as schemas, but the extent to which schemas can influence pain perception relative to bottom-up sensory inputs and the underlying neural underpinnings of such a phenomenon are unclear. Here, we investigate how threat predictions generated from learning a cognitive schema lead to inaccurate sensory impressions of the pain stimulus. Healthy male and female participants first detected a linear association between cue values and stimulus intensity and rated pain to reflect the linear schema when compared with uncued heat stimuli. The effect of bias on pain ratings was reduced when prediction errors (PEs) increased, but pain perception was only partially updated when measured against stepped increases in PEs. Cognitive, striatal, and sensory regions graded their responses to changes in predicted threat despite the PEs (p < 0.05, corrected). Individuals with more catastrophic thinking about pain and with low mindfulness were significantly more reliant on the schema than on the sensory evidence from the pain stimulus. These behavioral differences mapped to variability in responses of the striatum and ventromedial prefrontal cortex. Thus, this study demonstrates a significant role of higher-order schemas in pain perception and indicates that pain perception is biased more toward predictions and less toward nociceptive inputs in individuals who report less mindfulness and more fear of pain.SIGNIFICANCE STATEMENT This study demonstrates that threat predictions generated from cognitive schemas continue to influence pain perception despite increasing prediction errors arising in pain pathways. Individuals first formed a cognitive schema of linearity in the relationship between the cued threat value and the stimulus intensity. Subsequently, the linearity was reduced gradually, and participants partially updated their evaluations of pain in relation to the stepped increases in prediction errors. Individuals who continued to rate pain based more on the predicted threat than on changes in nociceptive inputs reported high pain catastrophizing and less mindful-awareness scores. These two affects mapped to activity in the ventral and dorsal striatum, respectively. These findings direct us to a significant role of top-down processes in pain perception.


Assuntos
Antecipação Psicológica/fisiologia , Encéfalo/fisiologia , Processos Mentais/fisiologia , Noxas , Percepção da Dor/fisiologia , Adulto , Mapeamento Encefálico , Catastrofização , Cognição/fisiologia , Corpo Estriado/fisiopatologia , Sinais (Psicologia) , Feminino , Temperatura Alta/efeitos adversos , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Medição da Dor , Limiar da Dor/fisiologia , Sensação/fisiologia , Córtex Somatossensorial/fisiopatologia , Adulto Jovem
15.
Rev. esp. salud pública ; 94: 0-0, 2020. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-193577

RESUMO

OBJETIVO: Existen pocos estudios epidemiológicos, sobre todo de tipo multicéntrico, sobre las intoxicaciones agudas a causa de productos químicos agroindustriales y del hogar en España. El objetivo de este trabajo fue describir el perfil epidemiológico y clínico de estas intoxicaciones en nuestro país, y analizar su evolución temporal. METODOS: El Sistema Español de Toxicovigilancia (SETv) es un registro prospectivo que incluye a 32 Servicios de Urgencias y Unidades de Cuidados intensivos de España. Se realizó un estudio descriptivo observacional de las intoxicaciones agudas por agentes químicos (excluyendo drogas y fármacos) en sus primeros 15 años de funcionamiento (1999-2014). Las comparaciones de proporciones se realizaron mediante las pruebas de Chi-cuadrado o exacta de Fisher, y entre pares de grupos independientes con la prueba de Mann-Whitney. Se consideraron significativos los valores de probabilidad menores de 0,05. RESULTADOS: Los 10.548 casos estudiados presentaban una edad media de 38,41 (+/-22,07) años, siendo significativamente superior en las mujeres (p=0,0001). El 67,7% de las intoxicaciones ocurrieron en el hogar, y las vías de entrada más frecuentes fueron la respiratoria (48,3%), la digestiva (35,3%) y la ocular (13,1%). Los grupos tóxicos más frecuentes fueron los gases tóxicos (31%), los cáusticos (25,6%) y los gases irritantes (12,1%). Un 76,2% de los casos requirieron tratamiento (27,2% con antídotos). Ingresó en un centro hospitalario un 20,6% de las personas, con una estancia media de 32 (+/-151,94) días, con diferencias significativas para los plaguicidas y disolventes (p=0,02). Presentaron secuelas al alta un 2,1%. La mortalidad fue del 1,4% (146 pacientes), con una edad media de 62,08 años (+/-19,58; p=0,0001). CONCLUSIONES: En las intoxicaciones por productos químicos, las medidas preventivas deben centrarse fundamentalmente en el ámbito doméstico, controlando las fuentes de exposición al monóxido de carbono y la manipulación de los productos de limpieza, fundamentalmente los líquidos cáusticos y la generación de gases irritantes al mezclarlos


OBJECTIVE: There are few epidemiological studies on acute poisonings from pesticides, industrials and household products in Spain. The objective of this work is to describe the epidemiological and clinical profile of acute poisonings by chemical products in our country, and analyze their annual evolution. METHODS: The Spanish Toxicovigilance System (SETv) is a prospective registry that includes 32 Emergency Departments and Intensive Care Units in Spain. An observational descriptive study of acute poisoning by chemical agents (excluding pharmacological products and illicit drugs) was carried out, within 1999-2014. Statistical analysis was performed using Chi-square or exact Fisher's tests. Non-parametric continuous variables were compared using the Mann-Whitney U test. P-value less than 0.05 were considered significant. RESULTS: The 10,548 cases studied had a mean age of 38.41 (+/-22.07) years, being significantly higher in women (p=0.0001). 67.7% of the poisonings occurred at home, and the most frequent routes of exposure were respiratory (48.3%), digestive (35.3%) and ocular (13.1%). The most frequent toxic groups were toxic gases (31%), caustics (25.6%) and irritant gases (12.1%). Of the patients that required treatment (76.2%), antidotes were used in 27.2%. 20.6% of the patients were admitted at Hospital, with a median stay of 32 (+/-151.94) days, with significant differences for pesticides and solvents (p=0.02). Sequelae were presented at discharge in 2.1% of patients. Mortality was 1.4% (146 patients) with a mean age of 62.08 years (+/-19.58) (p=0.0001). CONCLUSIONS: The reduction of chemical poisonings should be prevented in the domestic environment, taking into account the sources of exposure to carbon monoxide and the handling of household cleaning products, both caustic liquids and the generation of irritating gases when mixed


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Envenenamento/epidemiologia , Compostos Químicos/efeitos adversos , Noxas/envenenamento , Centros de Controle de Intoxicações/estatística & dados numéricos , Exposição a Produtos Químicos , Gás Tóxico , Tentativa de Suicídio/estatística & dados numéricos , Praguicidas/envenenamento , Detergentes/envenenamento , Cáusticos/envenenamento , Espanha/epidemiologia
16.
Arq. Inst. Biol ; 87: e0862018, 2020. tab, graf
Artigo em Inglês | ID: biblio-1118055

RESUMO

Production and storage environments influence the physiological and sanitary quality of seeds. This study aimed to evaluate the effects of the herbicide flumioxazin applied as a preharvest desiccant and storage on the physiological and sanitary quality of adzuki bean seeds. A randomized block design was used in a split-plot scheme, with four replications. Plots consisted of five doses of the herbicide flumioxazin (20, 25, 30, 35, and 40 g ai·ha-1) and subplots consisted of two evaluation times (harvest and six months after harvest). Two controls, with no herbicide application, were tested for each evaluation time. The physiological seed quality was maintained with doses from 25 to 35 g·ha-1 of flumioxazin. Increasing herbicide doses reduced the electrical conductivity of seeds. The increased doses also reduced the percentage of normal seedlings in the first germination count after six months of storage and caused seedling vigor loss. The storage of adzuki bean for six months reduced its physiological quality, leading to losses in germination and seed vigor. Storage and increasing doses of the desiccant flumioxazin reduced the incidence of the pathogens Rhizopus, Cladosporium, and Fusarium in the seeds. The increased doses of this herbicide reduced Aspergillus incidence. Penicillium incidence was not affected by treatments.(AU)


A qualidade fisiológica e sanitária de sementes é influenciada pelo ambiente de produção e de armazenamento. Neste trabalho objetivou-se avaliar os efeitos do herbicida flumioxazin aplicado como dessecante em pré-colheita e do armazenamento sobre a qualidade fisiológica e sanitária de sementes de feijão azuki. Foi adotado o delineamento experimental em blocos ao acaso, em esquema de parcelas subdivididas. Nas parcelas foram alocadas as cinco doses do herbicida flumioxazin (20, 25, 30, 35 e 40 g i.a·ha-1) e nas subparcelas as duas épocas de avaliação (colheita e 6 meses após a colheita), com quatro repetições. Foram testados dois tratamentos sem aplicação do herbicida para cada época de avaliação. Nas doses entre 25 a 35 g·ha-1 de flumioxazin observou-se a manutenção da qualidade fisiológica das sementes. Em doses crescentes reduziu-se a condutividade elétrica das sementes. O aumento das doses reduziu a porcentagem de plântulas normais na primeira contagem da germinação, após seis meses de armazenamento, e causou perda no vigor das plântulas. O armazenamento de feijão azuki durante seis meses reduziu a qualidade fisiológica, causando perdas na germinação e vigor das sementes. O armazenamento e o aumento das doses do dessecante flumioxazin reduziram a incidência dos patógenos Rhizopus, Cladosporium e Fusarium nas sementes. O aumento das doses reduziu a incidência de Aspergillus. A incidência de Penicillium não foi afetada pelos tratamentos.(AU)


Assuntos
Sementes/fisiologia , Vigna , Herbicidas/efeitos adversos , Higroscópicos , Noxas
17.
Arq. Inst. Biol ; 87: e0612019, 2020. graf
Artigo em Inglês | ID: biblio-1130105

RESUMO

The use of highly toxic pesticides to control soil pathogens, such as Fusarium spp. and Sclerotinia sclerotiorum has generated concern, due to the irreversible impacts caused on the environment, in addition to selecting resistant isolates. In this way, essential oils appear as an efficient alternative in control of diseases. Facing the problem of soil pathogens control and high antimicrobial fungicide that essential oils present, this work aimed to evaluate the in vitro fungicidal potential of essential oils in control of Fusarium spp. and S. sclerotiorum. A completely randomized design, factorial scheme 2×4×8 was used, with two isolates (Fusarium spp. and S. sclerotiorum), four essential oils (Aloysia citriodora, Cymbopogon winterianus, Lippia alba and Ocimum americanum), eight essential oil concentrations (0.0; 0.2; 0.4; 0.6; 0.8; 1.0; 1.2 and 1.4 ?L·mL-1), and ten replicates. The essential oils inhibited mycelial growth of the fungi in different concentrations, being their potential justified by the presence of antifungal chemical compounds. Essential oils of A. citriodora, C. winterianus, L. alba and O. americanum present high fungicidal potential, being viable alternatives for formulation of commercial products, boosting the pesticides industry.(AU)


O uso de pesticidas com alta toxicidade para controlar patógenos do solo, como Fusarium spp. e Sclerotinia sclerotiorum, tem gerado preocupação, devido aos impactos irreversíveis causados no meio ambiente, além de selecionar isolados resistentes. Dessa forma, os óleos essenciais surgem como uma alternativa eficiente no controle de doenças. Diante da problemática de controle de patógenos do solo e alto potencial antimicrobiano que os óleos essenciais possuem, este trabalho teve como objetivo avaliar o potencial fungicida de óleos essenciais no controle de Fusarium spp. e S. sclerotiorum, in vitro. Utilizou-se um delineamento inteiramente randomizado, esquema fatorial 2×4×8, com dois isolados (Fusarium spp. e S. sclerotiorum), quatro óleos essenciais (Aloysia citriodora, Cymbopogon winterianus, Lippia alba e Ocimum americanum) e oito concentrações de óleo essencial (0,0; 0,2; 0,4; 0,6; 0,8; 1,0; 1,2 e 1,4 ?L·mL-1), com dez repetições. Os óleos essenciais inibiram o crescimento micelial dos fungos em diferentes concentrações, sendo seu potencial justificado pela presença de compostos químicos antifúngicos. Os óleos essenciais de A. citriodora, C. winterianus, L. alba e O. americanum apresentam alto potencial fungicida, sendo alternativas viáveis para formulação de produtos comerciais, impulsionando a indústria de agrotóxicos.(AU)


Assuntos
Praguicidas/toxicidade , Uso de Praguicidas , Óleos Voláteis , Noxas , Ascomicetos , Solo , Ocimum canum , Meio Ambiente , Fusarium , Antifúngicos
18.
Med. UIS ; 32(3): 27-33, Sep.-Dec. 2019. tab
Artigo em Inglês | LILACS | ID: biblio-1114974

RESUMO

Abstract Genital hair is one of the secondary sexual traits that marks the beginning of puberty; its removal has been part of human culture since ancient times. This practice may lead to modifications in vaginal microbiome with potential repercussions on skin health and balance. We conducted a narrative review with the purpose of describing normal skin microbiota, its impact under microenvironment changes and genital hair removal. Menses, pathological conditions and pubic hair removal may alter vaginal microbiota, being the latter of special relevance giving the risk of hair microtrauma, irritations and potential spread of infectious agents. MÉD.UIS.2019;32(3):27-33


Resumo O cabelo genital é um dos traços sexuais secundários que marcam o início da puberdade; sua remoção faz parte da cultura humana desde os tempos antigos. Essa prática pode levar a modificações no microbioma vaginal com possíveis repercussões na saúde e equilíbrio da pele. Realizamos uma revisão narrativa com o objetivo de descrever a microbiota normal da pele, seu impacto nas alterações do microambiente e na remoção de pelos genitais. A menstruação, as condições patológicas e a remoção de pelos pubianos podem alterar a microbiota vaginal, sendo esta última de especial relevância dando o risco de microtraumatismo capilar, irritações e potencial disseminação de agentes infecciosos. MÉD.UIS.2019;32(3): 27-33


Resumen El vello genital es uno de los rasgos sexuales secundarios que marca el comienzo de la pubertad; su eliminación ha sido parte de la cultura humana desde la antigüedad. Esta práctica puede conducir a modificaciones en el microbioma vaginal con posibles repercusiones potenciales en la salud y el equilibrio de la piel. Realizamos una revisión narrativa con el propósito de describir la microbiota cutánea normal, su impacto bajo los cambios del microambiente y la depilación genital. La menstruación, las condiciones patológicas y la depilación púbica pueden alterar la microbiota vaginal, siendo esta última de especial relevancia dado el riesgo de microtraumatismos, irritaciones y posible propagación de agentes infecciosos. MÉD.UIS.2019;32(3): 27-33


Assuntos
Humanos , Feminino , Microbiota , Remoção de Cabelo , Ruptura , Pele , Staphylococcus , Actinomycetales , Humanos , Saúde , Risco , Puberdade , Dermatologia , Genitália Feminina , Cabelo , Infecções , Menstruação , Noxas
20.
Rev. colomb. reumatol ; 26(3): 151-159, jul.-set. 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1126330

RESUMO

Abstract Background & aim: Systemic lupus erythematosus is an autoimmune disease, its pathogenesis encompasses numerous organs. About 50% of cases of SLE are anemic; multiple pathways are attributed to the occurrence of anemia. Anemia of chronic disease is generally due to reduced erythropoietin function, reduced production and low response to erythropoietin action on red blood cells, which play a role in the development of anemia of chronic disease seen in several conditions with autoimmune etiology. There were three main contributions in our research: First: To evaluate the types of anemia associated with SLE. Second: To evaluate the role of erythropoietin in pathogenesis of SLE associated anemia. Third: To evaluate the correlation between level of anemia and erythropoietin level. Subjects & methodology: 150 patients with SLE were registered in our study. SLE activity was measured by SLE disease activity index. Results: Our study encompassed (150) SLE patients, 20 men and 130 women and (50) controls, 9 men and 41 women. Among them, anemia of chronic disease was the most prevalent (41.3%), then anemia due to iron deficiency (33.3%), and lastly anemia of autoimmune etiology (25.3%). Our study also showed that there was statistically significant dissimilarity (P value = 0.023) between all groups of anemia in erythropoietin value but there was no significant correlation between erythropoietin and hemoglobin levels in any of the three groups. Conclusion: Erythropoietin level variation was detected among the dissimilar groups of anemia but no correlation between hemoglobin level and erythropoietin was found (blunted erythropoietin response).


Resumen Antecedentes y objetivo: El lupus eritematoso sistémico (LES) es una enfermedad autoinmune, su patogénesis abarca numerosos órganos. Alrededor del 50% del lupus sistêmico es anémico; las múltiples vías se atribuyen a la aparición de anemia. La anemia por enfermedad crónica generalmente se debe a la función reducida de la eritropoyetina, la producción reducida y la baja respuesta a la acción de la eritropoyetina en los glóbulos rojos que desempeñan un papel en el desarrollo de la anemia de la enfermedad crónica observada en varias enfermedades con etiología autoinmune. Hubo 3 contribuciones principales en nuestra investigación: Primero: evaluar los tipos de anemia asociados con el lupus sistémico. Segundo: evaluar el papel de la eritropoyetina en la patogénesis de la anemia asociada al lupus sistêmico. Tercero: evaluar la correlación entre el nivel de anemia y el nivel de eritropoyetina. Sujetos y metodología: Ciento cincuenta pacientes con lupus sistémico se registraron en nuestro estudio. La actividad sistémica del lupus se calculó mediante el índice de actividad de la enfermedad del LES. Resultados: Nuestro estudio abarcó 150 pacientes con lupus sistêmico, 20 varones y 130 mujeres y 50 controles, 9 varones y 41 mujeres. Entre ellos, la anemia de la enfermedad crónica fue la más prevalente (41,3%), seguida de la anemia por deficiencia de hierro (33,3%) y, finalmente, la anemia con etiología autoinmune (25,3%). Nuestro estudio también mostró que hubo diferencias estadísticamente significativas (valor de p = 0,023) entre todos los grupos de anemia en el valor de eritropoyetina, pero no hubo una correlación significativa entre los niveles de eritropoyetina y hemoglobina en ninguno de los 3 grupos. Conclusión: Se detectó una variación en el nivel de eritropoyetina entre los diferentes grupos de anemia, pero no se encontró correlación entre el nivel de hemoglobina y la eritropoyetina (respuesta de eritropoyetina atenuada).


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Eritropoetina , Noxas , Prevalência , Anemia , Lúpus Eritematoso Sistêmico
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