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1.
Gene ; 807: 145888, 2022 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-34371096

RESUMO

BACKGROUND: Gestational diabetes mellitus (GDM) is a glucose intolerance condition encounters for the first time in a fraction of pregnant women. The role of different host inflammatory molecules in GDM etiology has been deciphered. Chemerin is a chemoattractant protein primarily associated with the pathogenesis of type 2 diabetes, obesity, and metabolic syndrome. However, the association of chemerin and its genetic variants with the predisposition of GDM is not clear, and our present study is aimed to address the issue. MATERIALS AND METHODS: A total of 703 Chinese women comprising of GDM (n = 303), glucose tolerant pregnant women (n = 211), and non-pregnant glucose tolerant controls (n = 189) were recruited in the present investigation. GDM was diagnosed according to the World Health Organization recommendation for diagnosis of gestational diabetes during pregnancy. Plasma levels of chemerin were quantified by an Enzyme-linked Immunosorbent Assay (ELISA). Common variants in the chemerin gene (rs4721, rs17173617, rs7806429, and rs17173608) were genotyped by using TaqMan assay. RESULTS: Plasma chemerin level was found higher in subjects with GDM as compared to glucose tolerant pregnant and non-pregnant women. Further, a positive correlation between plasma chemerin and HOMA-IR index suggesting an essential role of chemerin in mediating insulin resistance. Variants of rs4721 and rs17173608 polymorphisms were associated with lower levels of plasma chemerin and low HOMA-IR index. Furthermore, mutants of rs4721 and rs17173608 polymorphisms were associated with protection against the development of GDM in the Chinese cohort. CONCLUSIONS: Plasma chemerin is elevated in GDM patients. Genetic variation in chemerin gene associated with lower plasma levels of chemerin, HOMA-IR index and protects against the development of GDM in Chinese.


Assuntos
Quimiocinas/genética , Quimiocinas/metabolismo , Diabetes Gestacional/genética , Adulto , Grupo com Ancestrais do Continente Asiático/genética , Glicemia/genética , Quimiocinas/sangue , China , Estudos de Coortes , Diabetes Gestacional/metabolismo , Diabetes Gestacional/fisiopatologia , Testes Diagnósticos de Rotina/métodos , Ensaio de Imunoadsorção Enzimática/métodos , Feminino , Intolerância à Glucose/genética , Humanos , Insulina/metabolismo , Resistência à Insulina/genética , Resistência à Insulina/fisiologia , Síndrome Metabólica/genética , Obesidade/genética , Polimorfismo Genético/genética , Gravidez
2.
Food Chem ; 367: 130735, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34365247

RESUMO

Green and black teas are regarded to possess therapeutic potential for the treatment of obesity, however it is not clear which tea performs better in body weight control. In this study, aiming to eliminate cultivar variation, green tea phenolics (GTP) were oxidized by tyrosinase to obtain oxidized tea phenolics (OTP). Thereafter, their anti-obesity effect on high-fat diet induced obese mice were compared. The results showed that despite their distinctive phenolic profiles, GTP and OTP exerted similar anti-obesity properties after 12 weeks of dietary intervention. Furthermore, cecal microbiota profiling exhibited comparable modulatory effects of GTP and OTP on multiple bacterial taxa, including Parabacteroides distasonis, Bifidobacterium, Prevotella, and Akkermansia muciniphila, which were strongly associated with obesity related indexes. Putative bacterial function profiling implicated that both GTP and OTP might regulate the lipid metabolism similarly. Collectively, the oxidation of GTP did not influence the anti-obesity and gut microbiota modulatory effects to any large extent.


Assuntos
Microbioma Gastrointestinal , Chá , Animais , Bacteroidetes , Camundongos , Camundongos Obesos , Obesidade/tratamento farmacológico , Obesidade/etiologia
3.
Gene ; 807: 145950, 2022 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-34481003

RESUMO

This population-based longitudinal study is the first investigation that assesses the association of common MC4R SNPs with the obesity-related parameters over time and determines the effect of risk alleles during the three adulthood life periods (early, middle, and late) in a large Iranian cohort, a population with a unique genetic make-up that has been understudied and relatively unexplored. We obtained the genotype of 5370 unrelated adults who participated in the ongoing Tehran Cardiometabolic Genetic Study (TCGS) cohort project for the common MC4R SNPs. Linear regression and linear mixed model analyses were performed to examine the effect of MC4R polymorphisms on maximum BMI and other obesity-related factors over time. We recognized that several SNPs associated with the maximum BMI and the increased BMI, waist circumference, and waist-hip ratio across Iranian adults over a lifetime. Interestingly, we found that rs9954571-A has a yet unreported protective role against obesity-related factors, including BMI, waist circumference, waist-hip ratio, and triglyceride level. Additionally, a survey of the impact of the MC4R risk score throughout the adulthood life periods indicated that the MC4R risk score is influenced both the elevated BMI and waist circumference only during the early adulthood period. Our findings can expand our knowledge about the MC4R genetic variant's contributions to adulthood obesity and highlight the importance of evaluating the genetic components affecting obesity over a lifetime, which could be considered for obesity clinical screening and treatment.


Assuntos
Obesidade/genética , Receptor Tipo 4 de Melanocortina/genética , Adulto , Alelos , Índice de Massa Corporal , Estudos de Coortes , Feminino , Frequência do Gene/genética , Predisposição Genética para Doença/genética , Genótipo , Humanos , Irã (Geográfico)/epidemiologia , Estudos Longitudinais , Masculino , Programas de Rastreamento/métodos , Pessoa de Meia-Idade , Obesidade/metabolismo , Fenótipo , Polimorfismo de Nucleotídeo Único/genética , Receptor Tipo 4 de Melanocortina/metabolismo , Fatores de Risco , Circunferência da Cintura/genética , Relação Cintura-Quadril/métodos
4.
Biol Trace Elem Res ; 200(1): 281-297, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33624220

RESUMO

Given environmental contamination with toxic metals, diets that promote the elimination of these metals from the body of individuals, including those suffering from obesity, are urgently needed. The aim of this study was to determine the effects of supplementation with resveratrol (Res), L-carnitine (L-Car), tyrosine (Tyr), and tryptophan (Trp) on the content of trace elements in the organs of mice. DBA/2J mice and DBCB tetrahybrid mice received diets high in carbohydrate and fat supplemented with Res, L-Car, Tyr, or Trp for 65 days. In the liver, kidneys, and brain, the contents of 18 elements, including Al, As, Cu, Fe, Mn, Pb, Se, and Zn, were determined by inductively coupled plasma mass spectrometry. Res, L-Car, Tyr, and Trp had minimal or no effect on the essential elements (Fe, Mg, Cu, Zn, Se) in all organs studied. The Mn content notably increased in the organs of mice consuming L-Car and Trp. Mn accumulation was stimulated by Res in organs exclusively in DBCB mice and by Tyr exclusively in livers and brains of DBA/2J mice. Al levels were significantly reduced by L-Car and Trp in all organs of the mice, by Res in only DBCB mice, and by Tyr in only kidneys and livers of DBA/2J mice. In addition, L-Car and Trp decreased Pb accumulation in most organs of mice. Res and Tyr also inhibited Pb accumulation in some cases. Thus, the studied supplements affected the metabolism of trace elements, which may contribute to dietary treatments for obese individuals.


Assuntos
Oligoelementos , Aminoácidos Aromáticos , Animais , Carnitina/farmacologia , Dieta Hiperlipídica , Suplementos Nutricionais/análise , Camundongos , Camundongos Endogâmicos DBA , Obesidade/tratamento farmacológico , Resveratrol/farmacologia
5.
Braz. j. oral sci ; 20: e211359, jan.-dez. 2021. ilus
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1252506

RESUMO

Aim: To evaluate the effects of an intervention for the prevention of obesity on the prevalence of dental caries disease in Spanish children. Methods: Two cities participated intervention study nested in a cohort IDEFICS (Identification and prevention of dietary and lifestyle induced health effects in children and infants): Huesca, where there was a 2-year intervention, which encouraged less sugar consumption; and Zaragoza (control). The prevalence of caries was evaluated by examining the 1st permanent molars in the 7-11 age range, using the ICDAS (International Caries Detection and Assessment System). These teeth erupt at 6 years of age and at the baseline (2007-2008) were free of caries because they were not present in the oral cavity. As outcomes, white spots were selected, combining the ICDAS criteria 1 and 2, and untreated caries, combining criteria 4, 5 and 6. Their association with socioeconomic variables, BMI (Body Mass Index), frequency of sugar intake, sex and parents' perceptions of their children, was investigated. To do so, the chi-square test was applied (p<0.05). Results: The sample consisted of 281 children. The prevalence of white spots and untreated caries was higher in Huesca, despite the intervention. There was no association between the outcomes and the variables studied (p>0.05). Conclusion: The intervention for the prevention of obesity did not exert any association with the prevalence of caries in Spanish children


Assuntos
Humanos , Masculino , Feminino , Criança , Saúde Bucal , Cárie Dentária/epidemiologia , Obesidade
6.
Vínculo ; 18(2): 1-6, jul.-dez. 2021. ilus
Artigo em Português | LILACS, Index Psicologia - Periódicos | ID: biblio-1341802

RESUMO

Muitos são os problemas orgânicos ou psíquicos que surgem em indivíduos obesos. Diante desse mal-estar gerado pela obesidade, as angústias são relatadas com frequência por pacientes em discursos que giram em torno da alimentação e do corpo, carregados de frustrações que remetem a dietas fracassadas para dar conta da supervalorização de um corpo ideal na sociedade contemporânea. Nesse sentido, foi percebido nos relatos clínicos uma repetição, um ciclo vicioso que os pacientes têm dificuldade de interromper. Grande parte desses sujeitos relataram, nos atendimentos em grupo e individuais, que têm a comida como substituto de "algo", de um "vazio" que precisa ser preenchido, pois comem mesmo sem estarem com fome e com uma sensação de perda do controle sobre o ato. Por essa razão, após esse comportamento repetitivo, têm sentimentos de raiva, vergonha e culpa. Este artigo tem por objetivo investigar o mal-estar observado nas pessoas obesas atendidas individualmente na clínica particular e na instituição privada, bem como nos atendimentos realizados em grupo. Busca-se conhecimentos acerca da angústia em relação ao corpo obeso, com vistas a fomentar discussões embasadas pela orientação psicanalítica, utilizando durante os atendimentos a metodologia freudiana e a balintiana no atendimento de grupo.


Many are the organic or psychic problems that arise in obese individuals. Faced with this discomfort generated by obesity, anxieties are frequently reported by patients in discourses that revolve around diet and the body, loaded with frustrations that refer to failed diets to cope with the overvaluation of an ideal body in contemporary society. In this sense, it was perceived in clinical reports a repetition, a vicious cycle that patients have difficulty interrupting. Most of these subjects reported, in group and individual care, that they have food as a substitute for "something", a "void" that needs to be filled, because they eat even without being hungry and with a sense of loss of control over the act. For this reason, after this repetitive behavior, they have feelings of anger, shame and guilt. This article aims to investigate the discomfort observed in obese people treated individually in the private clinic and private institution, as well as in group care. Knowledge about anguish in relation to the obese body is sought, in order to foster discussions based on psychoanalytic orientation, using the Freudian and Balintian methodology during group care


Muchos son los problemas orgánicos o psíquicos que surgen en personas obesas. Frente a este malestar generado por la obesidad, los pacientes informan con frecuencia ansiedades en discursos que giran en torno a la dieta y el cuerpo, cargados de frustraciones que conducen a dietas fallidas para hacer frente a la sobrevaloración de un cuerpo ideal en la sociedad contemporánea. En este sentido, se percibió en los informes clínicos una repetición, un círculo vicioso que los pacientes tienen dificultades para interrumpir. La mayoría de estos sujetos informaron, en atención grupal e individual, que tienen comida como un sustituto de "algo", un "vacío" que necesita ser llenado, porque comen incluso sin tener hambre y con una sensación de pérdida de control sobre el acto Por esta razón, después de este comportamiento repetitivo, tienen sentimientos de ira, vergüenza y culpa. Este artículo tiene como objetivo investigar las molestias observadas en personas obesas tratadas individualmente en la clínica privada y la institución privada, así como en la atención grupal. Buscamos conocimiento sobre la angustia con respecto al cuerpo obeso, para fomentar discusiones basadas en la orientación psicoanalítica, utilizando durante la metodología freudiana y balintiana en la atención grupal.


Assuntos
Humanos , Ansiedade , Bulimia , Fome , Dieta , Emoções , Transtorno da Compulsão Alimentar , Insatisfação Corporal , Obesidade
7.
Infectio ; 25(4): 262-269, oct.-dic. 2021. tab, graf
Artigo em Inglês | LILACS, COLNAL | ID: biblio-1286720

RESUMO

Abstract Objective: To analyse the clinic characteristics, risk factors and evolution of the first cohort of hospitalised patients with confirmed infection by COVID-19 in 5 Colombian institutions. Materials and methods: Is a retrospective observational study of consecutive hospitalized patients with a diagnosis of COVID-19 confirmed from March 01 to May 30, 2020 in Colombia. Results: A total of 44 patients were included. The median age was 62 years. 43.2% had a history of smoking, while 69.8% were overweight or obese. 88.6% had at least one comorbidity and 52.3% had three or more comorbidities. Hypertension and dyslipidaemia were the most frequent comorbidities (40.9% and 34.1%, respectively). The 30-day mortality rate was 47.7% with a median of 11 days. The composite outcome occurred in the 36.4%. The biomarkers associated with mor tality risk included troponin higher than 14 ng/L (RR: 5.25; 95% CI 1.37-20.1, p = 0.004) and D-dimer higher than 1000 ng/ml (RR: 3.0; 95% CI 1.4-6.3, p = 0.008). Conclusions: The clinical course of SARS-CoV-2 infection in hospitalized Colombian was characterised by a more advanced stage of the infection.


Resumen Objetivo: Analizar las características, clínicas, factores de riesgo, y la evolución de pacientes hospitalizados con infección confirmada por COVID-19 en 5 Institu ciones de Colombia. Material y método: Es un estudio observacional retrospectivo de pacientes consecutivos hospitalizados con diagnóstico de COVID-19 confirmado entre 01 de Febrero de 2020 y 30 de Mayo de 2020 en Colombia. Resultados: Un total de 44 pacientes fueron incluidos. La mediana de edad fue de 62 años y la mayoría del sexo masculino. El 43.2% tenían historia de tabaquismo, mientras que el 69.8% tenían sobrepeso u obesidad. El 88.6% tenían al menos una comorbilidad y el 52.3% tenían tres o más comorbilidades. La hipertensión arterial fue la comorbilidad más frecuente (40.9%), seguido de la dislipidemia (34.1%). La tasa de letalidad a 30 días fue de 47.7% y ocurrió con una mediana de 11 días. El 36.4% presentó el desenlace compuesto. Los biomarcadores asociados con el riesgo de muerte fue troponina > 14 ng/mL (RR:5.25, IC95% 1.37-20.1, p=0.004) y dímero D mayor a 1000 mg/dL (RR: 3.0, IC95% 1.4-6.3, p=0.008). Conclusiones: El curso clínico de la infección por SARS-CoV-2 en colombianos hospitalizados fue un estadio más avanzado de la infección.


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Biomarcadores , COVID-19 , Pacientes , Tabagismo , Comorbidade , Risco , Fatores de Risco , Mortalidade , Colômbia , Sobrepeso , Cursos , Infecções , Obesidade
8.
Multimedia | Recursos Multimídia | ID: multimedia-9474

RESUMO

Nos dias 29 e 30 de setembro de 2021, foi realizado o seminário virtual “Guias Alimentares baseados no nível de processamento dos alimentos: evidências científicas e implementação”, uma iniciativa da Coordenação Geral de Alimentação e Nutrição (CGAN) do Ministério da Saúde em parceria com a Organização Pan-Americana da Saúde/ Organização Mundial da Saúde (OPAS/OMS). O objetivo do seminário virtual foi disseminar evidências científicas recentes sobre o impacto do nível de processamento dos alimentos na saúde, na obesidade e outras doenças crônicas, bem como discutir estratégias de implementação e disseminação de Guias Alimentares baseados no nível de processamento dos alimentos nas Américas. O seminário faz parte das atividades da Rede de Ação sobre Guias Alimentares baseados no nível de processamento dos alimentos nas Américas, liderada pelo Ministério da Saúde do Brasil, desde 2018, com o apoio da OPAS/OMS e da Organização das Nações Unidas para Agricultura e Alimentação (FAO). Em 2017, o Brasil foi o primeiro país a assumir compromissos para enfrentar todas as formas de desnutrição, considerando o papel dos sistemas alimentares, no âmbito da Década de Ação pela Nutrição das Nações Unidas (2016-2015).


Assuntos
Dieta Saudável , Guias Alimentares , Segurança Alimentar , Comportamento Alimentar , Alimentos Integrais , Alimentos Industrializados , América Latina , Região do Caribe , Vulnerabilidade Social , Obesidade/prevenção & controle , Estilo de Vida Saudável
9.
Multimedia | Recursos Multimídia | ID: multimedia-9476

RESUMO

Nos dias 29 e 30 de setembro de 2021, foi realizado o seminário virtual “Guias Alimentares baseados no nível de processamento dos alimentos: evidências científicas e implementação”, uma iniciativa da Coordenação Geral de Alimentação e Nutrição (CGAN) do Ministério da Saúde em parceria com a Organização Pan-Americana da Saúde/ Organização Mundial da Saúde (OPAS/OMS). O objetivo do seminário virtual foi disseminar evidências científicas recentes sobre o impacto do nível de processamento dos alimentos na saúde, na obesidade e outras doenças crônicas, bem como discutir estratégias de implementação e disseminação de Guias Alimentares baseados no nível de processamento dos alimentos nas Américas. O seminário faz parte das atividades da Rede de Ação sobre Guias Alimentares baseados no nível de processamento dos alimentos nas Américas, liderada pelo Ministério da Saúde do Brasil, desde 2018, com o apoio da OPAS/OMS e da Organização das Nações Unidas para Agricultura e Alimentação (FAO). Em 2017, o Brasil foi o primeiro país a assumir compromissos para enfrentar todas as formas de desnutrição, considerando o papel dos sistemas alimentares, no âmbito da Década de Ação pela Nutrição das Nações Unidas (2016-2015).


Assuntos
Dieta Saudável , Guias Alimentares , Segurança Alimentar , Obesidade/prevenção & controle , Comportamento Alimentar , América Latina , Alimentos Industrializados , Vulnerabilidade Social , Nutrição da Criança , Desnutrição/prevenção & controle , Bebidas Adoçadas com Açúcar
14.
Multimedia | Recursos Multimídia | ID: multimedia-9331

RESUMO

A obesidade é uma doença crônica, multifatorial e complexa caracterizada pelo excesso de gordura corporal. No entanto, quando se pensa nas causas, logo vem em mente uma alimentação inadequada associada à falta de prática de atividade física regular, colocando o problema como algo que depende somente das escolhas individuais. Por esse motivo, não é difícil que as pessoas com obesidade sofram com o preconceito e com a culpabilização do indivíduo . Para entender melhor o assunto, convidamos a Dra Olivia Barata Cavalcanti.


Assuntos
Obesidade/psicologia , Estigma Social , Bullying , Isolamento Social/psicologia , Estresse Psicológico , Hidrocortisona/efeitos adversos , Alimentos Industrializados ,
15.
Multimedia | Recursos Multimídia | ID: multimedia-9336

RESUMO

A obesidade é uma doença crônica caracterizada pelo acúmulo de gordura corporal. No Brasil, os índices de indivíduos com excesso de peso têm saltado significativamente, passando a ser uma questão de saúde pública.


Assuntos
Obesidade/prevenção & controle , Obesidade/complicações , Comportamento Alimentar , Fatores Sociais , Documentários Cinematográficos , Comportamento Sedentário
16.
Recurso na Internet em Inglês, Português | LIS - Localizador de Informação em Saúde | ID: lis-48524

RESUMO

Atualmente, uma em cada três pessoas está com sobrepeso ou obesidade e uma em cada nove pessoas passa fome no mundo.


Assuntos
Sobrepeso , Obesidade , Obesidade Pediátrica
17.
Multimedia | Recursos Multimídia | ID: multimedia-9316

RESUMO

The Coca-Cola Effect: In Mexico, Coca Cola is more than just a brand. Its factories deplete water supplies for vast areas, whilst its products contribute to a burgeoning obesity epidemic. In one small Mexican village, residents are praying for rain. The ceremony appears traditional, apart from one element: a dozen or so bottles of Coca Cola. ”It’s seen as a sacred drink now", explains one resident. ”It allows you to purify your soul. That’s the power of Coca Cola.” Ironically, it is the presence of Coca Cola’s nearby factory that is partly to blame for the dearth in drinking water. The factory uses six litres of water for every litre of cola and draws it from the area’s dwindling groundwater supply. Now residents have to buy water from tankers. “I spend a quarter of my salary on getting water", says resident Rodolfo. In fact, it can be cheaper to drink solely Coca Cola: Mexico has become the biggest consumer of the soft drink in the world, to the detriment of the population’s health. The extent to which a single corporation can affect a nation is nowhere more pertinent than here.


Assuntos
Bebidas Adoçadas com Açúcar , Indústria de Bebidas Gaseificadas , Obesidade/epidemiologia , Recursos Naturais , Água Potável , Vulnerabilidade Social , Pobreza , Documentários Cinematográficos , México/epidemiologia
18.
Wiad Lek ; 74(9 cz 1): 2039-2043, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34725273

RESUMO

OBJECTIVE: The aim: To determine the influence of obesity on cutaneous microcirculation in patients with different stages of obesity and without cardio-vascular pathologies. PATIENTS AND METHODS: Materials and methods: The 67 eligible patients with obesity were enrolled into the main group in this research. 20 healthy patients with normal body weight were included in the control group in this study. The mean age and gender were similar among the groups. Each patient underwent a clinical evaluation during the consultation, biological tests, electrocardiogram, Laser Doppler flowmetry. RESULTS: Results: There was a significant decrease in IM and σ in patients with class II obesity and class III obesity compared with control group. IV was decreased in all groups, but the significant differences were recorded only among patients with obesity and not among overweight patients. During wavelet analysis a significant decrease of the AmaxE was detected in all 4 groups (by 14,7%, 37,7%, 52,4%, 57,4% respectively, P < 0,05). The most significant changes were recorded in the heart spectrum (AmaxC). CONCLUSION: Conclusions: Overweight patients and patients with obesity without cardio-vascular pathology have initial manifestations of microcirculatory disorders, which deteriorate with an increase of BMI. Changes in microcirculation in patients with obesity characterized by the significant decrease of microvessels perfusion, decreasing endothelial and increasing heart specter modulations. Only high BMI was found to be associated with impaired microcirculation endothelial function (AmaxE B=0.446, 95% CI [0,15, 0,92]) according to the results of regression analysis.


Assuntos
Obesidade , Pele , Humanos , Fluxometria por Laser-Doppler , Microcirculação , Microvasos , Obesidade/complicações
19.
Wiad Lek ; 74(9 cz 1): 2152-2158, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34725292

RESUMO

OBJECTIVE: The aim: To study the peculiarities of CD68+ and CD163+ macrophage expression in the placentas of women with obesity who developed preeclampsia by applying immunohistochemical method. PATIENTS AND METHODS: Materials and methods: The study included 20 placentas taken from women who delivered full-term live-birth babies. The women were divided into 4 groups of 5 individuals each: women with physiological body weight (1st group); women with class II obesity (2nd group); women with physiological body weight and preeclampsia (3rd group); women with class II obesity, who developed preeclampsia (4th group). RESULTS: Results: The analysis of the expression level of CD68+ and CD163+ decidual macrophages shows the predominance of CD68+ pro-inflammatory profile over CD163+ anti-inflammatory profile in women of all groups. Evaluation of CD68+ and CD163+ expression levels of Kashchenko-Hofbauer cells in the stroma of the terminal villi of the placentashows that the expression level of CD68+ macrophages is significantly higher in women with obesity and preeclampsia than in the control, or in women with obesity or preeclampsia. There was a reverse tendency to the polarization shift in Kashchenko-Hoffbauer cells in the stroma of the terminal villi towards the predominance of CD163+ macrophages over CD68+ macrophages in all groups of women. CONCLUSION: Conclusions: The imbalance in anti-inflammatory and pro-inflammatory profile of placental macrophages with a predominance of the latter can lead to the development of preeclampsia.


Assuntos
Pré-Eclâmpsia , Antígenos CD , Antígenos de Diferenciação Mielomonocítica , Feminino , Humanos , Obesidade/complicações , Placenta , Gravidez , Receptores de Superfície Celular
20.
Wiad Lek ; 74(9 cz 1): 2218-2221, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34725304

RESUMO

The prevalence of obesity is growing at alarming rate worldwide. Obesity has reached the proportion of a global epidemic in both developed and developing countries. Growing number of obese patients with atrial fibrillation requires a closer look at how excessive body fat leads to AF. Excessive adipose tissue is the source of many cardiovascular diseases, like hypertension, ischemic heart disease, and arrhythmias such as atrial fibrillation. The prevalence of atrial fibrillation in the general population is estimated at 1-2%. Obesity and overweight occur in 25% of patients with AF. Pathophysiology of obesity and the relationship between atrial fibrillation, diabetes, obstructive sleep apnea and metabolicsyndrome are presented in this article as well as the benefit of bariatric surgery in qualifying patients. Paroxysmal AF and its risk factors should be carefully assessed in all patients referred for bariatric surgery. Proper diagnosis allows physicians to introduce appropriate anticoagulant prophylaxis, and significantly lower complication rate. Antiarrhythmic, respiratory, and metabolic therapy should also be considered in preoperative and postoperative care.


Assuntos
Fibrilação Atrial , Cirurgia Bariátrica , Hipertensão , Fibrilação Atrial/epidemiologia , Fibrilação Atrial/etiologia , Fibrilação Atrial/prevenção & controle , Cirurgia Bariátrica/efeitos adversos , Humanos , Obesidade/complicações , Obesidade/epidemiologia , Fatores de Risco
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