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2.
Immun Inflamm Dis ; 12(7): e1301, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38967361

RESUMO

OBJECTIVE: Acute pancreatitis (AP) stands as a frequent cause for clinical emergency hospital admissions. The X-box binding protein 1 (XBP1) was found to be implicated in pancreatic acinar cell apoptosis. The objective is to unveil the potential mechanisms governed by XBP1 and SIRT6 in the context of AP. METHODS: Caerulein-treated human pancreatic duct epithelial (HPDE) cells to establish an in vitro research model. The levels and regulatory role of SIRT6 in the treated cells were evaluated, including its effects on inflammatory responses, oxidative stress, apoptosis, and endoplasmic reticulum stress. The relationship between XBP1 and SIRT6 was explored by luciferase and ChIP experiments. Furthermore, the effect of XBP1 overexpression on the regulatory function of SIRT6 on cells was evaluated. RESULTS: Caerulein promoted the decrease of SIRT6 and the increase of XBP1 in HPDE cells. Overexpression of SIRT6 slowed down the secretion of inflammatory factors, oxidative stress, apoptosis level, and endoplasmic reticulum stress in HPDE cells. However, XBP1 negatively regulated SIRT6, and XBP1 overexpression partially reversed the regulation of SIRT6 on the above aspects. CONCLUSION: Our study illuminates the role of XBP1 in downregulating SIRT6 in HPDE cells, thereby promoting cellular injury. Inhibiting XBP1 or augmenting SIRT6 levels holds promise in preserving cell function and represents a potential therapeutic avenue in the management of AP.


Assuntos
Apoptose , Regulação para Baixo , Células Epiteliais , Ductos Pancreáticos , Pancreatite , Sirtuínas , Proteína 1 de Ligação a X-Box , Humanos , Sirtuínas/metabolismo , Sirtuínas/genética , Células Epiteliais/metabolismo , Proteína 1 de Ligação a X-Box/metabolismo , Proteína 1 de Ligação a X-Box/genética , Pancreatite/metabolismo , Pancreatite/patologia , Ductos Pancreáticos/metabolismo , Ductos Pancreáticos/patologia , Estresse do Retículo Endoplasmático , Estresse Oxidativo , Linhagem Celular , Ceruletídeo/toxicidade
3.
Khirurgiia (Mosk) ; (6): 15-19, 2024.
Artigo em Russo | MEDLINE | ID: mdl-38888014

RESUMO

OBJECTIVE: To evaluate the effectiveness and safety of electrohydraulic lithotripsy of calculi of the main pancreatic duct using ultrathin SpyGlass DS endoscope. MATERIAL AND METHODS: The study included 29 patients with chronic calcifying pancreatitis and obstructive calculi of the main pancreatic duct. All surgeries were carried out between 2018 and 2023. RESULTS: Complete removal of calculi (≥5 mm) within one procedure was achieved in 25 (86%) patients. CONCLUSION: Pancreatoscopy with electrohydraulic lithotripsy using the digital SpyGlass DS system (BostonScientificCorp, Marlborough, MA) is the most effective method for calculi of the main pancreatic duct.


Assuntos
Litotripsia , Pancreatite Crônica , Humanos , Pancreatite Crônica/cirurgia , Pancreatite Crônica/diagnóstico , Litotripsia/métodos , Masculino , Pessoa de Meia-Idade , Feminino , Ductos Pancreáticos/cirurgia , Adulto , Cálculos/cirurgia , Cálculos/diagnóstico , Resultado do Tratamento , Endoscopia do Sistema Digestório/métodos , Endoscopia do Sistema Digestório/instrumentação , Colangiopancreatografia Retrógrada Endoscópica/métodos , Calcinose/cirurgia , Calcinose/diagnóstico
4.
Khirurgiia (Mosk) ; (6): 5-14, 2024.
Artigo em Russo | MEDLINE | ID: mdl-38888013

RESUMO

OBJECTIVE: To analyze the efficacy of intraductal radiofrequency ablation (RFA) for neoplasms of the major duodenal papilla with intraductal spread. MATERIAL AND METHODS: Eleven patients with adenomas of the major duodenal papilla and intraductal spread underwent intraductal RFA between 2022 and 2023. Spread to the common bile duct ranged from 10 to 30 mm, to the main pancreatic duct - from 5 to 11 mm. RESULTS: Technical success was achieved in all cases. Complications after intraductal RFA occurred in 4 cases (post-manipulation pancreatitis - 2 cases, repeated intraductal RFA for residual adenomatous growths - 2 cases). Technical success of stenting of the main pancreatic and common bile ducts was achieved in all cases. CONCLUSION: Intraductal radiofrequency ablation for neoplasms of the major duodenal papilla with intraductal spread ensured complete destruction of intraductal tumor with adequate clinical effect and no need for highly traumatic surgery.


Assuntos
Ampola Hepatopancreática , Ablação por Radiofrequência , Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Ampola Hepatopancreática/cirurgia , Ablação por Radiofrequência/métodos , Idoso , Ductos Pancreáticos/cirurgia , Resultado do Tratamento , Complicações Pós-Operatórias/etiologia
5.
Pancreas ; 53(6): e528-e536, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38888841

RESUMO

OBJECTIVES: Although prevalent in 50%-90% of pancreatic ductal adenocarcinomas, the clinical relevance of "cancerization of ducts" (COD) remains unknown. METHODS: Pathologists retrospectively reviewed slides classifying prevalence of COD. Histopathological parameters, location of first recurrence, recurrence-free survival (RFS), and overall survival (OS) were collected from the institutional pancreatectomy registry. RESULTS: Among 311 pancreatic ductal adenocarcinomas, COD was present in 216 (69.5%) and more prevalent in the cohort that underwent upfront surgery (75.3% vs 63.1%, P = 0.019). Furthermore, COD was associated with female gender (P = 0.040), advanced T stage (P = 0.007), perineural invasion (P = 0.014), lymphovascular invasion (P = 0.025), and R1 margin (P = 0.009), but not N stage (P = 0.401) or tumor differentiation (P = 0.717). In multivariable regression, COD was associated with less liver recurrence (odds ratio, 0.44; P < 0.005). This association was driven by the cohort of patients who had received preoperative treatment (odds ratio, 0.18; P < 0.001). COD was not predictive for RFS or OS. CONCLUSIONS: Cancerization of ducts was not associated with RFS or OS. Currently underrecognized, standardized implementation into histopathological reports may have merit, and further mechanistic scientific experiments need to illuminate its clinical and biologic impact.


Assuntos
Carcinoma Ductal Pancreático , Pancreatectomia , Neoplasias Pancreáticas , Humanos , Carcinoma Ductal Pancreático/cirurgia , Carcinoma Ductal Pancreático/patologia , Carcinoma Ductal Pancreático/mortalidade , Masculino , Feminino , Neoplasias Pancreáticas/cirurgia , Neoplasias Pancreáticas/patologia , Neoplasias Pancreáticas/mortalidade , Estudos Retrospectivos , Idoso , Pessoa de Meia-Idade , Pancreatectomia/métodos , Recidiva Local de Neoplasia , Intervalo Livre de Doença , Ductos Pancreáticos/patologia , Ductos Pancreáticos/cirurgia , Relevância Clínica
8.
Clin Transl Med ; 14(6): e1733, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38877637

RESUMO

BACKGROUND AND AIMS: Smoking is recognised as an independent risk factor in the development of chronic pancreatitis (CP). Cystic fibrosis transmembrane conductance regulator (CFTR) function and ductal fluid and bicarbonate secretion are also known to be impaired in CP, so it is crucial to understand the relationships between smoking, pancreatic ductal function and the development of CP. METHODS: We measured sweat chloride (Cl-) concentrations in patients with and without CP, both smokers and non-smokers, to assess CFTR activity. Serum heavy metal levels and tissue cadmium concentrations were determined by mass spectrometry in smoking and non-smoking patients. Guinea pigs were exposed to cigarette smoke, and cigarette smoke extract (CSE) was prepared to characterise its effects on pancreatic HCO3 - and fluid secretion and CFTR function. We administered cerulein to both the smoking and non-smoking groups of mice to induce pancreatitis. RESULTS: Sweat samples from smokers, both with and without CP, exhibited elevated Cl- concentrations compared to those from non-smokers, indicating a decrease in CFTR activity due to smoking. Pancreatic tissues from smokers, regardless of CP status, displayed lower CFTR expression than those from non-smokers. Serum levels of cadmium and mercury, as well as pancreatic tissue cadmium, were increased in smokers. Smoking, CSE, cadmium, mercury and nicotine all hindered fluid and HCO3 - secretion and CFTR activity in pancreatic ductal cells. These effects were mediated by sustained increases in intracellular calcium ([Ca2+]i), depletion of intracellular ATP (ATPi) and mitochondrial membrane depolarisation. CONCLUSION: Smoking impairs pancreatic ductal function and contributes to the development of CP. Heavy metals, notably cadmium, play a significant role in the harmful effects of smoking. KEY POINTS: Smoking and cigarette smoke extract diminish pancreatic ductal fluid and HCO3 - secretion as well as the expression and function of CFTR Cd and Hg concentrations are significantly higher in the serum samples of smokers Cd accumulates in the pancreatic tissue of smokers.


Assuntos
Metais Pesados , Pancreatite Crônica , Humanos , Pancreatite Crônica/metabolismo , Pancreatite Crônica/induzido quimicamente , Animais , Metais Pesados/metabolismo , Masculino , Camundongos , Feminino , Pessoa de Meia-Idade , Cobaias , Adulto , Ductos Pancreáticos/metabolismo , Ductos Pancreáticos/efeitos dos fármacos , Regulador de Condutância Transmembrana em Fibrose Cística/metabolismo , Fumar/efeitos adversos , Fumar/metabolismo , Modelos Animais de Doenças
9.
Rev. esp. patol ; 57(2): 137-140, Abr-Jun, 2024. ilus
Artigo em Espanhol | IBECS | ID: ibc-232420

RESUMO

El tumor fibroso calcificante (TFC) es una inusual lesión benigna de origen mesenquimal que puede presentar características similares a otros tumores más comunes. El caso involucra a una mujer de 36 años con un tumor en el yeyuno proximal, inicialmente sospechoso de ser un tumor del estroma gastrointestinal (GIST). Se realiza una resección quirúrgica, revelando un nódulo bien delimitado en el borde antimesentérico con características microscópicas típicas de TFC. Las células tumorales presentaban positividad para CD34 y negatividad para demás marcadores, diferenciándolo de otras neoplasias. El TFC puede confundirse con tumores más comunes debido a su apariencia, pero un diagnóstico preciso respaldado por inmunohistoquímica es esencial. La extirpación quirúrgica completa suele ser curativa. (AU)


Calcifying fibrous tumor (CFT) is a rare benign lesion of mesenchymal origin that may present similar characteristics to other more common tumors. We present the case of a 36-year-old woman with a tumor in the proximal jejunum, initially suspected to be a gastrointestinal stromal tumor (GIST). Surgical resection was performed, revealing a well-demarcated nodule at the anti-mesenteric border with microscopic features typical of a calcifying fibrous tumor. The tumor cells were positive for CD34 and negative for other markers, differentiating it from other neoplasms. Calcifying fibrous tumors can be confused with more common tumors because of its appearance, but an accurate diagnosis supported by immunohistochemistry is essential. Complete surgical excision is usually curative. (AU)


Assuntos
Humanos , Animais , Neoplasias , Células-Tronco Mesenquimais , Imuno-Histoquímica , Ductos Pancreáticos , Ferimentos e Lesões
11.
Ann Intern Med ; 177(6): 749-758, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38801774

RESUMO

BACKGROUND: No randomized controlled trials have substantiated endoscopic decompression of the pancreatic duct in patients with painful chronic pancreatitis. OBJECTIVE: To investigate the pain-relieving effect of pancreatic duct decompression in patients with chronic pancreatitis and intraductal stones. DESIGN: 24-week, parallel-group, randomized controlled trial (ClinicalTrials.gov: NCT03966781). SETTING: Asian Institute of Gastroenterology in India from February 2021 to July 2022. PARTICIPANTS: 106 patients with chronic pancreatitis. INTERVENTION: Combined extracorporeal shock-wave lithotripsy (ESWL) and endoscopic retrograde pancreatography (ERP) compared with sham procedures. MEASUREMENTS: The primary end point was pain relief on a 0- to 10-point visual analog scale (VAS) at 12 weeks. Secondary outcomes were assessed after 12 and 24 weeks and included 30% pain relief, opioid use, pain-free days, questionaries, and complications to interventions. RESULTS: 52 patients in the ESWL/ERP group and 54 in the sham group were included. At 12 weeks, the ESWL/ERP group showed better pain relief compared with the sham group (mean difference in change, -0.7 [95% CI, -1.3 to 0] on the VAS; P = 0.039). The difference between groups was not sustained at the 24-week follow-up, and no differences were seen for 30% pain relief at 12- or 24-week follow-up. The number of pain-free days was increased (median difference, 16.2 days [CI, 3.9 to 28.5 days]), and the number of days using opioids was reduced (median difference, -5.4 days [CI, -9.9 to -0.9 days]) in the ESWL/ERP group compared with the sham group at 12-week follow-up. Safety outcomes were similar between groups. LIMITATION: Single-center study and limited duration of follow-up. CONCLUSION: In patients with chronic pancreatitis and intraductal stones, ESWL with ERP provided modest short-term pain relief. PRIMARY FUNDING SOURCE: Asian Institute of Gastroenterology and Aalborg University Hospital.


Assuntos
Colangiopancreatografia Retrógrada Endoscópica , Litotripsia , Ductos Pancreáticos , Pancreatite Crônica , Humanos , Pancreatite Crônica/complicações , Pancreatite Crônica/terapia , Masculino , Feminino , Litotripsia/efeitos adversos , Litotripsia/métodos , Pessoa de Meia-Idade , Adulto , Colangiopancreatografia Retrógrada Endoscópica/efeitos adversos , Ductos Pancreáticos/diagnóstico por imagem , Medição da Dor , Dor Abdominal/etiologia , Dor Abdominal/terapia , Manejo da Dor/métodos , Resultado do Tratamento
12.
Zhonghua Wai Ke Za Zhi ; 62(7): 697-702, 2024 Jul 01.
Artigo em Chinês | MEDLINE | ID: mdl-38808437

RESUMO

Objectives: To evaluate the efficacy and safety of the self-fixing and self-detachable drainage stent in pancreaticojejunostomy and to provide supportive data for the follow clinical trials. Methods: This is an experimental research in animals which completed from February 2022 to September 2022. A self-fixing and self-detachable pancreaticojejunostomy drainage stent was designed for Hong's pancreaticojejunostomy technique based on the theory of "fistula healing" in pancreaticojejunostomy. Ten biocompatibility tests were completed in vitro before this study. Twenty-five Bama minipigs were selected and double-ligated in the neck of the pancreas to dilate the distal main pancreatic duct. Twenty-three of them were successfully modelled and divided into three groups by a stratified random method: pancreaticojejunostomy drainage stent group (referred to as stent group) with 11 pigs, pancreatic duct to jejunal mucosa anastomosis group (referred to as manual suture group) with 8 pigs, sham operation group with 4 pigs. The anastomic time,amylase content in postoperative abdominal drainage fluid and the tolerable pressure value of pancreaticojejunostomy were compared between the stent group and the manual suture group. An abdominal X-ray fluoroscopy examination was adopted to detect the detach time of the stent. A postoperative pathological examination was performed to verify the healing time,the type of treatment and the stricture rate of pancreaticojejunostomy. Quantitative data was analyzed by independent sample t-test. The classified data were analyzed by Fisher's exact test. Results: There were no significant differences in the diameter of the pancreatic duct and pancreatic texture,the time of pancreaticojejunostomy,the amylase content in postoperative peritoneal drainage fluid,and the tolerable pressure value of the pancreaticojejunostomy between the stent group and the manual suture group(all P>0.05). Abdominal X-ray fluoroscopy showed that the stents gradually detached and were removed from the body 21 days after operation,and all stents were detached in the follow 3 months after operation. Pancreaticojejunostomy healed 7 days after operation based on fistula formation in the stent group,and 14 days in the manual suture group. The incidence of anastomotic stricture within 35 days after operation was 2/8 in the stent group and 6/8 in the manual suture group (Fisher's exact test: P=0.132). Conclusion: The stent method is safer and simpler than the manual suture method in pancreaticojejunostomy of Bama minipigs, with shorter anastomotic healing time and lower stricture rate.


Assuntos
Anastomose Cirúrgica , Drenagem , Pancreaticojejunostomia , Stents , Animais , Suínos , Pancreaticojejunostomia/métodos , Drenagem/métodos , Anastomose Cirúrgica/métodos , Pâncreas/cirurgia , Ductos Pancreáticos/cirurgia
13.
Gastrointest Endosc Clin N Am ; 34(3): 417-431, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38796290

RESUMO

Per-oral pancreatoscopy (POP) is a pancreas-preserving modality that allows for targeted pancreatic duct interventions, particularly in cases where standard techniques fail. POP specifically has an emerging role in the diagnosis, risk stratification, and disease extent determination of main duct intraductal papillary mucinous neoplasms (IPMNs). It has also been successfully used for laser ablation of IPMNs in poor surgical candidates, lithotripsy for complex stone disease, and laser stricturoplasty. As experience with POP increases beyond select referral center practices, further studies validating POP efficacy with long-term follow-up will help clarify when POP-guided intervention is most beneficial in relation to surgical intervention.


Assuntos
Pancreatopatias , Humanos , Pancreatopatias/terapia , Pancreatopatias/cirurgia , Endoscopia do Sistema Digestório/métodos , Ductos Pancreáticos/cirurgia , Ductos Pancreáticos/patologia , Neoplasias Pancreáticas/terapia , Neoplasias Pancreáticas/cirurgia , Neoplasias Intraductais Pancreáticas/terapia , Neoplasias Intraductais Pancreáticas/cirurgia
14.
Gastrointest Endosc Clin N Am ; 34(3): 433-448, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38796291

RESUMO

Pain secondary to chronic pancreatitis is a poorly understood and complex phenomenon. Current endoscopic treatments target pancreatic duct decompression secondary to strictures, stones, or inflammatory and neoplastic masses. When there is refractory pain and other treatments have been unsuccessful, one can consider an endoscopic ultrasound-guided celiac plexus block. Data on the latter are underwhelming.


Assuntos
Endossonografia , Manejo da Dor , Pancreatite Crônica , Humanos , Pancreatite Crônica/complicações , Endossonografia/métodos , Manejo da Dor/métodos , Plexo Celíaco/cirurgia , Ductos Pancreáticos/cirurgia , Bloqueio Nervoso/métodos , Dor Abdominal/etiologia , Colangiopancreatografia Retrógrada Endoscópica/métodos
15.
Gastrointest Endosc Clin N Am ; 34(3): 501-510, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38796295

RESUMO

Endoscopic ultrasound-guided pancreatic duct drainage (EUS-PDD) is a method of decompressing the pancreatic duct (PD) if unable to access the papilla or surgical anastomosis, particularly in nonsurgical candidates. The 2 types of EUS-PDD are EUS-assisted pancreatic rendezvous (EUS-PRV) and EUS-guided pancreaticogastrostomy (EUS-PG). EUS-PRV should be considered in patients with accessible papilla or anastomosis, while EUS-PG is a comparable alternative in surgically altered foregut anatomy. While technical and clinical successes range from 79% to 100%, adverse events occur in approximately 20%. A multidisciplinary approach that considers the patient's anatomy, clinical indication, and long-term goals should be discussed with surgical and interventional radiology colleagues.


Assuntos
Drenagem , Endossonografia , Ductos Pancreáticos , Ultrassonografia de Intervenção , Humanos , Drenagem/métodos , Ductos Pancreáticos/cirurgia , Ductos Pancreáticos/diagnóstico por imagem , Endossonografia/métodos , Ultrassonografia de Intervenção/métodos , Stents
16.
Gastrointest Endosc Clin N Am ; 34(3): 405-416, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38796289

RESUMO

Pancreatic duct (PD) leaks are a common complication of acute and chronic pancreatitis, trauma to the pancreas, and pancreatic surgery. Diagnosis of PD leaks and fistulas is often made with contrast-enhanced pancreatic protocol computed tomography or magnetic resonance imaging with MRCP. Endoscopic retrograde pancreatography with pancreatic duct stenting in appropriately selected patients is often an effective treatment, helps to avoid surgery, and is considered first-line therapy in cases that fail conservative management.


Assuntos
Colangiopancreatografia Retrógrada Endoscópica , Ductos Pancreáticos , Fístula Pancreática , Stents , Humanos , Colangiopancreatografia Retrógrada Endoscópica/métodos , Fístula Pancreática/etiologia , Fístula Pancreática/terapia , Fístula Pancreática/diagnóstico por imagem , Fístula Pancreática/cirurgia , Ductos Pancreáticos/diagnóstico por imagem , Ductos Pancreáticos/cirurgia , Pancreatite/etiologia , Pancreatite/diagnóstico por imagem , Pancreatite/terapia , Tomografia Computadorizada por Raios X , Complicações Pós-Operatórias/etiologia
19.
Front Immunol ; 15: 1381319, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38742118

RESUMO

Introduction: Inflammation of the pancreas contributes to the development of diabetes mellitus. Although it is well-accepted that local inflammation leads to a progressive loss of functional beta cell mass that eventually causes the onset of the disease, the development of islet inflammation remains unclear. Methods: Here, we used single-cell RNA sequencing to explore the cell type-specific molecular response of primary human pancreatic cells exposed to an inflammatory environment. Results: We identified a duct subpopulation presenting a unique proinflammatory signature among all pancreatic cell types. Discussion: Overall, the findings of this study point towards a role for duct cells in the propagation of islet inflammation, and in immune cell recruitment and activation, which are key steps in the pathophysiology of diabetes mellitus.


Assuntos
Inflamação , Ductos Pancreáticos , Análise de Célula Única , Transcriptoma , Humanos , Ductos Pancreáticos/patologia , Ductos Pancreáticos/metabolismo , Ductos Pancreáticos/imunologia , Inflamação/imunologia , Inflamação/genética , Perfilação da Expressão Gênica , Diabetes Mellitus/imunologia , Diabetes Mellitus/genética , Diabetes Mellitus/metabolismo , Células Cultivadas , Mediadores da Inflamação/metabolismo
20.
Dig Dis Sci ; 69(6): 2018-2025, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38580887

RESUMO

INTRODUCTION: Pancreatic duct stents (PDS) are widely used for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. However, there is a paucity of data regarding the adverse events associated with PDS placement. This study aims to investigate the reported adverse events and device failures related to PDS, utilizing the Manufacturer and User Facility Device Experience (MAUDE) database maintained by the U.S. Food and Drug Administration (FDA). METHODS: Post-marketing surveillance data from January 2013 to December 8, 2023, were extracted from the FDA's MAUDE database to analyze the reports pertaining to the use of commonly used PDS. The primary outcomes of interest were device issues and patient-related adverse events. Statistical analysis was performed using Microsoft Excel 2010, with the calculation of pooled numbers and percentages for each device and patient adverse event. RESULTS: A total of 579 device issues and 194 patient-related adverse events were identified. Device issues were primarily attributed to stent deformation (n = 72; 12.4%), followed by migration of the device into the pancreatic duct or expulsion out of the duct (n = 60; 10.4%), and stent fracture/breakage (n = 55; 9.4%). Among the patient-reported adverse events, inflammation was the most common (n = 26; 13.4%), followed by reports of stents becoming embedded in tissue (n = 21; 10.8%) and stent occlusion/obstruction (n = 16; 8.2%). The most prevalent device failures associated with Advanix stents were material deformation, with perforation (n = 3, 30%) being the most frequently reported adverse event. Concerning Geenen stents, migration or expulsion of the device (n = 34, 16.9%) constituted the most common device-related adverse events, while inflammation (n = 20, 16.7%) was the most frequently reported patient-related issue. For Zimmon stents, migration or expulsion of the device (n = 22, 8.8%) were the most frequently reported device-related problems, whereas perforation (n = 7, 10.9%) and bleeding (n = 7, 10.9%) were the most frequent patient-related adverse events. CONCLUSION: Our findings highlight important device and patient adverse events that endoscopists and referring providers should be aware of before considering pancreatic stent placement.


Assuntos
Bases de Dados Factuais , Ductos Pancreáticos , Vigilância de Produtos Comercializados , Falha de Prótese , Stents , United States Food and Drug Administration , Humanos , Estados Unidos/epidemiologia , Stents/efeitos adversos , Ductos Pancreáticos/cirurgia , Colangiopancreatografia Retrógrada Endoscópica/efeitos adversos , Colangiopancreatografia Retrógrada Endoscópica/instrumentação , Pancreatite/etiologia , Pancreatite/epidemiologia , Pancreatite/prevenção & controle , Falha de Equipamento/estatística & dados numéricos , Migração de Corpo Estranho/etiologia , Migração de Corpo Estranho/epidemiologia , Migração de Corpo Estranho/prevenção & controle
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