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1.
Geneva; World Health Organization; 2022. (WHO/HEP/NFS/SSA/2022.1).
em Inglês | WHO IRIS | ID: who-352191
2.
Asian Pac J Cancer Prev ; 22(7): 2295-2302, 2021 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-34319055

RESUMO

Background: Glioblastoma is the most common primary malignant tumor of the central nervous system that occurs in the spinal cord or brain. Pseudosynanceia melanostigma is a venomous stonefish in the Persian Gulf, which our knowledge about is little. This study's goal is to investigate the toxicity of stonefish crude venom on mitochondria isolated from U87 cells. Methods: In the first stage, we extracted venom stonefish and then isolated mitochondria have exposed to different concentrations of venom. Finally, mitochondrial toxicity parameters (Succinate dehydrogenase (SDH) activity, Reactive oxygen species (ROS), cytochrome c release, Mitochondrial Membrane Potential (MMP), and mitochondrial swelling) have evaluated. Results: To determine mitochondrial parameters, we used 115, 230, and 460 µg/ml concentrations. The results of our study show that the venom of stonefish selectively increases upstream parameters of apoptosis such as mitochondrial swelling, cytochrome c release, MMP collapse and ROS. Conclusion: This study suggests that Pseudosynanceia melanostigma crude venom has selectively caused toxicity by increasing active mitochondrial oxygen radicals. This venom could potentially be a candidate for the treatment of glioblastoma.


Assuntos
Venenos de Peixe/farmacologia , Peixes Venenosos , Glioblastoma/tratamento farmacológico , Mitocôndrias/efeitos dos fármacos , Células Tumorais Cultivadas/efeitos dos fármacos , Animais , Apoptose/efeitos dos fármacos , Citocromos/efeitos dos fármacos , Oceano Índico , Potenciais da Membrana/efeitos dos fármacos , Espécies Reativas de Oxigênio , Succinato Desidrogenase/efeitos dos fármacos
3.
Mar Drugs ; 19(6)2021 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-34073964

RESUMO

Stonefish are regarded as one of the most venomous fish in the world. Research on stonefish venom has chiefly focused on the in vitro and in vivo neurological, cardiovascular, cytotoxic and nociceptive effects of the venom. The last literature review on stonefish venom was published over a decade ago, and much has changed in the field since. In this review, we have generated a global map of the current distribution of all stonefish (Synanceia) species, presented a table of clinical case reports and provided up-to-date information about the development of polyspecific stonefish antivenom. We have also presented an overview of recent advancements in the biomolecular composition of stonefish venom, including the analysis of transcriptomic and proteomic data from Synanceia horrida venom gland. Moreover, this review highlights the need for further research on the composition and properties of stonefish venom, which may reveal novel molecules for drug discovery, development or other novel physiological uses.


Assuntos
Mordeduras e Picadas/epidemiologia , Mordeduras e Picadas/terapia , Venenos de Peixe/envenenamento , Peixes Venenosos , Animais , Mordeduras e Picadas/complicações , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/terapia , Venenos de Peixe/análise , Venenos de Peixe/química , Peixes Venenosos/fisiologia , Geografia , Humanos , Oceano Índico/epidemiologia , Doenças Neuromusculares/epidemiologia , Doenças Neuromusculares/etiologia , Doenças Neuromusculares/terapia , Oceano Pacífico/epidemiologia
4.
Toxicon ; 184: 78-82, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32473254

RESUMO

Stonefish sting lethality in man has been scarcely documented since the middle of the 20th century. We report three clinical cases, including one fatality, emphasizing the cardiovascular toxicity of the Synanceia verrucosa venom, and its potentially lethal effects. All clinical data have been recently collected in New Caledonia and French Polynesia.


Assuntos
Mordeduras e Picadas , Venenos de Peixe , Peixes Venenosos , Animais , Humanos , Perciformes
6.
PLoS One ; 13(11): e0206749, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30383854

RESUMO

Indo-Pacific red lionfish (Pterois volitans) have invaded the western Atlantic, and most recently the northern Gulf of Mexico (nGOM), at a rapid pace. Given their generalist habitat affinities and diet, and strong ecological overlap with members of the commercially valuable snapper-grouper complex, increased density and abundance of lionfish could result in significant competitive interactions with nGOM commercially important species. We experimentally investigated the intensity of behavioral interactions between lionfish and indigenous, abundant and economically important juvenile nGOM red snapper (Lutjanus campechanus), and other increasingly abundant juvenile tropical snapper species (gray snapper-L. griseus and lane snapper-L. synagris) in large outdoor mesocosms to examine snapper vulnerabilities to lionfish competition. When paired with lionfish, red snapper swimming activity (i.e., time swimming and roving around experimental tank or at structure habitat during experiments) was significantly lower than in intraspecific control trials, but gray and lane snapper swimming activities in the presence of lionfish did not significantly differ from their intraspecific controls. Additionally in paired trials, red and lane snapper swimming activities were significantly lower than those of lionfish, while no significant difference in swimming activities was observed between lionfish and gray snapper. We found that red snapper prey consumption rates in the presence of lionfish were significantly lower than in their intraspecific 3-individual control trials, but when paired together no significant differences in prey consumption rates between red snapper and lionfish were observed. When paired with lane or gray snapper, lionfish were observed having comparatively higher prey consumption than snappers, or as observed in lionfish intraspecific 1-individual controls. However, lane and gray snapper consumption rates in the presence of lionfish did not significantly differ from those in intraspecific controls. These findings suggest that competition between juvenile snappers and invasive lionfish may be variable, with lionfish exhibiting differing degrees of competitive dominance and snappers exhibiting partial competitive vulnerability and resistance to lionfish. While the degree of intensity at which these interactions may occur in nGOM reefs may differ from those observed in our findings, this study enables greater understanding of the potential ecological effects of red lionfish on native reef fishes.


Assuntos
Agressão , Peixes Venenosos , Espécies Introduzidas , Perciformes , Comportamento Predatório , Natação , Animais , Tamanho Corporal , Braquiúros , Comportamento Competitivo , Meio Ambiente , Golfo do México
7.
Wilderness Environ Med ; 29(3): 343-356, 2018 09.
Artigo em Inglês | MEDLINE | ID: mdl-29954662

RESUMO

INTRODUCTION: Recent analyses of data show a warming trend in global average air and sea surface ocean temperatures. The atmosphere and ocean have warmed, the amounts of snow and ice have diminished, the sea level has risen, and the concentrations of greenhouse gases have increased. This article will focus on climate change and projected effects on venomous marine and amphibious creatures with the potential impact on human health. METHODS: Retrospective analysis of environmental, ecological, and medical literature with a focus on climate change, toxinology, and future modeling specific to venomous aquatic and amphibious creatures. Species included venomous jellyfish, poisonous fish, crown-of-thorns starfish, sea snakes, and toxic frogs. RESULTS: In several projected scenarios, rising temperatures, weather extremes, and shifts in seasons will increase poisonous population numbers, particularly with certain marine creatures like jellyfish and crown-of-thorns starfish. Habitat expansions by lionfish and sea snakes are projected to occur. These phenomena, along with increases in human populations and coastal development will likely increase human-animal encounters. Other species, particularly amphibious toxic frogs, are declining rapidly due to their sensitivity to any temperature change or subtle alterations in the stability of their environment. If temperatures continue to rise to record levels over the next decades, it is predicted that the populations of these once plentiful and critically important animals to the aquatic ecosystem will decline and their geographic distributions will shrink. CONCLUSION: Review of the literature investigating the effect and forecasts of climate change on venomous marine and amphibious creatures has demonstrated that temperature extremes and changes to climatic norms will likely have a dramatic effect on these toxicological organisms. The effects of climate change on these species through temperature alteration and rising coastal waters will influence each species differently and in turn potentially affect commercial industries, travel, tourism, and human health.


Assuntos
Anfíbios , Mudança Climática , Peixes Venenosos , Hydrophiidae , Venenos de Anfíbios , Anfíbios/fisiologia , Animais , Cnidários/fisiologia , Ecologia , Venenos Elapídicos , Meio Ambiente , Peixes Venenosos/fisiologia , Humanos , Hydrophiidae/fisiologia , Peçonhas , Meio Selvagem
9.
Toxicon ; 142: 45-51, 2018 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29294314

RESUMO

The Reef Stonefish (Synanceia verrucosa) is one of the most dangerous venomous fish known, and has caused occasional human fatalities. The present study was designed to examine some of the pathological effects of the venom from this fish in Sprague Dawley rats. Crude venom was extracted from venom glands of the dorsal spines of stonefish specimens collected from coral reefs in the Gulf of Aqaba (in the northeastern branch of the Red Sea). The rats were given intramuscular injections of the venom and acute toxicity and effect on selected serum marker enzymes as well as normal architecture of vital organs were evaluated. The rat 24 h LD50 was 38 µg/kg body weight. The serum biochemical markers; alanine transaminase (ALT), lactate dehydrogenase (LDH) and creatine kinase (CK) increased after 6 h of administration of a sub lethal dose of the venom and remained significantly raised at 24 h. Amylase levels also significantly increased after venom injection. The venom caused histological damage manifested as an interstitial hemorrhage, inflammatory cell infiltration, and necrosis. The demonstrated rises in the levels of different critical biochemical parameters in the serum may have led to the observed abnormal morphological changes in these organs. These results may account for some of the clinical manifestations observed in victims of stonefish envenomation. Thus, the presented data provide further in vivo evidence of the stonefish toxic effects that may threaten human life and call for the need for special measures to be considered.


Assuntos
Venenos de Peixe/toxicidade , Peixes Venenosos , Perciformes , Animais , Biomarcadores/sangue , Venenos de Peixe/química , Venenos de Peixe/isolamento & purificação , Coração/efeitos dos fármacos , Rim/efeitos dos fármacos , Rim/patologia , Dose Letal Mediana , Fígado/efeitos dos fármacos , Fígado/patologia , Pulmão/efeitos dos fármacos , Pulmão/patologia , Masculino , Miocárdio/patologia , Ratos , Ratos Sprague-Dawley , Testes de Toxicidade Aguda
10.
Toxicon ; 140: 139-146, 2017 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-29055787

RESUMO

Rabbitfish belonging to the order Perciformes are well-known venomous fish that are frequently involved in human accidents. However little research has been done into either the whole venom toxicities or the structures and properties of their venom toxins. In this study, we first examined biological activities of the crude venom extract prepared from dorsal spines of Siganus fuscescens, a rabbitfish most commonly found along the coasts of Japan. As a result, the crude venom extract was shown to have mouse-lethal activity, hemolytic activity against rabbit erythrocytes, edema-forming activity and nociceptive activity, similar to the known scorpaeniform fish toxins (stonefish toxins and their analogues). Then, the primary structure of the S. fuscescens toxin was successfully elucidated by the same cDNA cloning strategy as previously employed for the toxins of some scorpaeniform fish (lionfish, devil stinger and waspfish). The S. fuscescens toxin is obviously an analogue of stonefish toxins, being composed of two kinds of subunits, an α-subunit of 703 amino acid residues and a ß-subunit of 699 amino acid residues. Furthermore, the genes encoding both subunits were cloned from genomic DNA and shown to have an architecture of three exons and two introns, as reported for those of the scorpaeniform fish toxins. This study is the first to demonstrate the occurrence of stonefish toxin-like toxins in perciform fish.


Assuntos
Venenos de Peixe/toxicidade , Peixes Venenosos , Perciformes , Sequência de Aminoácidos , Animais , Clonagem Molecular , Edema/induzido quimicamente , Venenos de Peixe/química , Venenos de Peixe/genética , Hemólise/efeitos dos fármacos , Masculino , Camundongos , Coelhos , Análise de Sequência de DNA
11.
Diving Hyperb Med ; 47(3): 155-158, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28868595

RESUMO

OBJECTIVES: To investigate the effects of temperature and hot water immersion time on neutralising venom lethality of the Australian estuarine stonefish (Synanceia horrida). DESIGN: Depths of the spines were measured while venom was extracted from S. horrida individuals. The venom was then exposed to temperatures of 4°C, 37.0°C, 40.1°C, 42.3°C, 45.0°C, 47.7°C, 55.2°C, and 60.0°C for either five or 20 minutes incubation periods. Venom samples were added to cultured human cardiomyocytes and cell viability curves were produced using the ACEA's xCELLigence real-time cell monitoring system. MAIN OUTCOME MEASURES: Determination of venom lethality on cardiomyocytes at a range of temperatures. RESULTS: The average depth of the spine required to go into a victims' flesh before the venom gland compressed and expelled venom was 18 mm. Cardiomyocytes exposed to heat-treated venom for five minutes required higher temperatures to neutralise 99% of the venom, namely 44.6°C in comparison to 42.1°C with an incubation time of 20 minutes. CONCLUSION: This study supports the use of hot water immersion therapy in the treatment of S. horrida stings. It is suggested that due to the depth of the puncture wound longer incubation times should be sought to allow heat to penetrate the deeper portions of the dermis and effectively begin venom deactivation.


Assuntos
Mordeduras e Picadas/terapia , Primeiros Socorros/métodos , Venenos de Peixe/envenenamento , Peixes Venenosos , Temperatura Alta/uso terapêutico , Miócitos Cardíacos/efeitos dos fármacos , Análise de Variância , Animais , Austrália , Venenos de Peixe/administração & dosagem , Peixes Venenosos/anatomia & histologia , Humanos , Imersão , Fatores de Tempo
12.
Ugeskr Laeger ; 179(27)2017 Jul 03.
Artigo em Dinamarquês | MEDLINE | ID: mdl-28689545

RESUMO

The greater weever (Trachinus draco) is the only venomous fish in Denmark, and if stung by the weever the venom may cause symptoms such as pain, headache, nausea, dizziness and in severe cases systemic allergic reaction or tissue necrosis. The venom is heat-labile and should therefore be treated with warm water to the afflicted area. We report a case of a patient who was stung in the second finger and because of the treatment, he got a second-degree burn, that may have enhanced the effect of the venom, thus resulting in partial finger amputation.


Assuntos
Mordeduras e Picadas/complicações , Queimaduras/etiologia , Traumatismos dos Dedos/etiologia , Peixes Venenosos , Hipertermia Induzida/efeitos adversos , Animais , Mordeduras e Picadas/patologia , Mordeduras e Picadas/terapia , Queimaduras/patologia , Queimaduras/cirurgia , Traumatismos dos Dedos/patologia , Traumatismos dos Dedos/cirurgia , Venenos de Peixe/efeitos adversos , Humanos , Masculino , Pessoa de Meia-Idade
13.
Toxins (Basel) ; 9(2)2017 02 16.
Artigo em Inglês | MEDLINE | ID: mdl-28212333

RESUMO

Fish venoms are often poorly studied, in part due to the difficulty in obtaining, extracting, and storing them. In this study, we characterize the cardiovascular and neurotoxic effects of the venoms from the following six species of fish: the cartilaginous stingrays Neotrygon kuhlii and Himantura toshi, and the bony fish Platycephalus fucus, Girella tricuspidata, Mugil cephalus, and Dentex tumifrons. All venoms (10-100 µg/kg, i.v.), except G. tricuspidata and P. fuscus, induced a biphasic response on mean arterial pressure (MAP) in the anesthetised rat. P. fucus venom exhibited a hypotensive response, while venom from G. tricuspidata displayed a single depressor response. All venoms induced cardiovascular collapse at 200 µg/kg, i.v. The in vitro neurotoxic effects of venom were examined using the chick biventer cervicis nerve-muscle (CBCNM) preparation. N. kuhlii, H. toshi, and P. fucus venoms caused concentration-dependent inhibition of indirect twitches in the CBCNM preparation. These three venoms also inhibited responses to exogenous acetylcholine (ACh) and carbachol (CCh), but not potassium chloride (KCl), indicating a post-synaptic mode of action. Venom from G. tricuspidata, M. cephalus, and D. tumifrons had no significant effect on indirect twitches or agonist responses in the CBCNM. Our results demonstrate that envenoming by these species of fish may result in moderate cardiovascular and/or neurotoxic effects. Future studies aimed at identifying the molecules responsible for these effects could uncover potentially novel lead compounds for future pharmaceuticals, in addition to generating new knowledge about the evolutionary relationships between venomous animals.


Assuntos
Doenças Cardiovasculares/induzido quimicamente , Sistema Cardiovascular/efeitos dos fármacos , Venenos de Peixe/toxicidade , Peixes Venenosos/metabolismo , Junção Neuromuscular/efeitos dos fármacos , Síndromes Neurotóxicas/etiologia , Animais , Pressão Arterial/efeitos dos fármacos , Doenças Cardiovasculares/fisiopatologia , Sistema Cardiovascular/fisiopatologia , Galinhas , Relação Dose-Resposta a Droga , Venenos de Peixe/metabolismo , Peixes Venenosos/classificação , Contração Muscular/efeitos dos fármacos , Junção Neuromuscular/fisiopatologia , Síndromes Neurotóxicas/fisiopatologia , Ratos , Fatores de Tempo
14.
Toxicon ; 125: 19-23, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27867093

RESUMO

BACKGROUND: The potential costs of venom production may be significant to many marine venomous taxa. In general, the parameters that influence the rate of venom production are poorly understood, but seem to be related to feeding frequency. METHODS: This study examines the effects of starvation on venom profile and venom yield on the estuarine stonefish (Synanceia horrida). In total, the venom of eight stonefishes was tested under two feeding regimes. Over a four week period, one of the two groups underwent an episode of suspended feeding, while the other was fed on a daily basis. The effect of time on venom replacement was determined by a paired T-test. ANOVA was performed to analyze differences in venom weight between fed and unfed treatments. RESULTS: Nutritional suspension was found to have a significant effect on the quantity of venom produced. SDS-PAGE gel and FPLC revealed that the components of the venom collected from both groups were similar, indicating that four weeks is an adequate time to regenerate key venom components but not replenish initial venom quantities. CONCLUSIONS: Venom production was found to be affected by starvation.


Assuntos
Comportamento Alimentar , Venenos de Peixe/metabolismo , Peixes Venenosos/fisiologia , Perciformes/fisiologia , Animais , Dieta , Peixes Venenosos/metabolismo , Perciformes/metabolismo , Inanição/metabolismo , Fatores de Tempo
17.
J Travel Med ; 22(4): 251-8, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25884785

RESUMO

BACKGROUND: The Scorpaenidae are a large family of venomous marine fish that include scorpionfish, lionfish, and stonefish. Although most stonefish are confined to the Indo-Pacific, scorpionfish are distributed in the tropics worldwide, and two species of Indo-Pacific lionfish were inadvertently introduced into the Eastern Atlantic in the 1990s. Since then, lionfish have invaded shallow reef systems in the Eastern Atlantic, Gulf of Mexico, and Caribbean Sea. All of these regions are popular travel destinations for beachcombing, fishing, swimming, and scuba diving-recreational activities that increase risks of Scorpaenidae envenomation. METHODS: To meet the objectives of describing species-specific presenting clinical manifestations, diagnostic and treatment strategies, and outcomes of Scorpaenidae envenomation in travelers, Internet search engines were queried with the key words. RESULTS: Well-conducted, retrospective epidemiological investigations of Scorpaenidae envenomation case series concluded: (1) most cases occurred in young adult male vacationers visiting endemic regions; (2) victims sought medical attention for pain control within 2 hours of injury and presented with intense pain, edema, and erythema in affected extremities; (3) systemic manifestations and surgical interventions were relatively uncommon following initial management with hot water soaks and parenteral analgesics; (4) all cases required tetanus prophylaxis; deeply penetrating, lacerated, and necrotic wounds required antibiotic prophylaxis; and (5) equine Fab stonefish antivenom does have antigen-neutralizing cross-reactivities with both Indo-Pacific and Atlantic Scorpaenidae species and is indicated in severe scorpionfish and stonefish envenomation worldwide. CONCLUSIONS: Travel medicine practitioners should counsel their patients about Scorpaenidae envenomation risks in endemic regions and maintain a high index of suspicion regarding Scorpaenidae envenomation in all travelers returning from tropical beach and ocean holidays and reporting painful fish sting injuries.


Assuntos
Mordeduras e Picadas , Peixes Venenosos/classificação , Viagem , Adulto , Animais , Mordeduras e Picadas/diagnóstico , Mordeduras e Picadas/epidemiologia , Mordeduras e Picadas/etiologia , Mordeduras e Picadas/fisiopatologia , Mordeduras e Picadas/terapia , Gerenciamento Clínico , Venenos de Peixe , Humanos , Medicina Preventiva/métodos , Fatores de Risco , Medicina de Viagem/métodos
18.
Gac. méd. espirit ; 17(1): 82-92, ene.-abr. 2015. ilus, tab
Artigo em Espanhol | LILACS | ID: biblio-953637

RESUMO

Fundamento: El alza creciente de las intoxicaciones accidentales por picaduras y exposiciones al Pterois volitans (pez león) en los últimos años en Cuba, es debido a la presencia en el entorno marino cubano de este particular espécimen. Existe cierto desconocimiento por el personal de salud cubano en cuanto a la conducta a seguir de esta intoxicación debido a la relativa escasez de bibliografía. Objetivo: Profundizar en aspectos esenciales de la intoxicación por pez león, como la toxina involucrada, el cuadro clínico y la conducta a seguir. Desarrollo: Se realizó una revisión bibliográfica de artículos relacionados con la intoxicación por pez león, en diferentes bases de datos médicas de prestigio, donde se hizo énfasis en la toxina involucrada, las principales manifestaciones clínicas y medidas fundamentales dirigidas al tratamiento adecuado de la intoxicación. Conclusiones: La intoxicación por pez león además de causar un intenso dolor es capaz de producir una sintomatología muy variada y exacerbada, por lo que deben tomarse medidas específicas para una adecuada conducta a seguir, y así evitar complicaciones. Son muy frecuentes los casos clínicos atendidos con urgencia tras accidente con este tipo de pez; por lo que es necesario divulgar su potencial toxicológico.


Background: the increase of accidental intoxication by biting and exposure to Pterois volitans fish in the last years in Cuba is due to the presence of this fish in the Cuban sea world. There is evident lack of knowledge by Cuban health personnel with relation to the way to behave with this kind of intoxication due to the lack of bibliography written about it. Objective: To deepen on Pterois volitans fish intoxication essentialities as involved toxin, clinical picture and behavior. Development: A bibliographical revision of articles related to intoxication by Pterois volitans fish was carried out, the main focus was directed to the involved toxin, main clinical manifestations and measures directed to the right treatment of this intoxication. Conclusion: Intoxication by Pterois volitans fish causes a varied and exacerbated symptomatology. For this reason, it is necessary to take specific measures to avoid complications. Clinical cases attended after accident by this type of fish are very frequent what makes necessary to spread its toxicological potentiality.


Assuntos
Humanos , Intoxicação/epidemiologia , Peixes Venenosos/lesões , Mordeduras e Picadas/epidemiologia , Fauna Aquática
19.
Gac méd espirit ; 17(1)ene.-abr. 2015.
Artigo em Espanhol | CUMED | ID: cum-60185

RESUMO

El alza creciente de las intoxicaciones accidentales por picaduras y exposiciones al Pterois volitans (pez león) en los últimos años en Cuba, es debido a la presencia en el entorno marino cubano de este particular espécimen. Existe cierto desconocimiento por el personal de salud cubano en cuanto a la conducta a seguir de esta intoxicación debido a la relativa escasez de bibliografía. Objetivo: Profundizar en aspectos esenciales de la intoxicación por pez león, como la toxina involucrada, el cuadro clínico y la conducta a seguir. Desarrollo: Se realizó una revisión bibliográfica de artículos relacionados con la intoxicación por pez león, en diferentes bases de datos médicas de prestigio, donde se hizo énfasis en la toxina involucrada, las principales manifestaciones clínicas y medidas fundamentales dirigidas al tratamiento adecuado de la intoxicación. Conclusiones: La intoxicación por pez león además de causar un intenso dolor es capaz de producir una sintomatología muy variada y exacerbada, por lo que deben tomarse medidas específicas para una adecuada conducta a seguir, y así evitar complicaciones. Son muy frecuentes los casos clínicos atendidos con urgencia tras accidente con este tipo de pez; por lo que es necesario divulgar su potencial toxicológico.(AU)


the increase of accidental intoxication by biting and exposure to Pterois volitans fish in the last years in Cuba is due to the presence of this fish in the Cuban sea world. There is evident lack of knowledge by Cuban health personnel with relation to the way to behave with this kind of intoxication due to the lack of bibliography written about it. Objective: To deepen on Pterois volitans fish intoxication essentialities as involved toxin, clinical picture and behavior. Development: A bibliographical revision of articles related to intoxication by Pterois volitans fish was carried out, the main focus was directed to the involved toxin, main clinical manifestations and measures directed to the right treatment of this intoxication. Conclusion: Intoxication by Pterois volitans fish causes a varied and exacerbated symptomatology. For this reason, it is necessary to take specific measures to avoid complications. Clinical cases attended after accident by this type of fish are very frequent what makes necessary to spread its toxicological potentiality.(AU)


Assuntos
Humanos , Animais , Peixes Venenosos/lesões , Toxicidade , Intoxicação/epidemiologia , Mordeduras e Picadas/epidemiologia , Fauna Aquática , Fauna Marinha
20.
Gac. méd. espirit ; 17(1): 78-85, ene.-abr. 2015. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-743974

RESUMO

Fundamento: La didáctica de las ciencias estomatológicas cubanas acumula experiencias que justifican las características actuales del proceso de enseñanza-aprendizaje en la asignatura Ortodoncia de la carrera de estomatología. Objetivo: Identificar los aspectos históricos que distinguen el proceso de enseñanza-aprendizaje en la asignatura Ortodoncia, en la educación estomatológica cubana. Metodología: Se empleó el método analítico-sintético, el histórico-lógico y el análisis documental con la revisión de bases de datos médicas de reconocido prestigio. Desarrollo: Se logró establecer una secuencia lógica de hechos trascendentes en la enseñanza-aprendizaje de la asignatura Ortodoncia desde sus inicios, cuatro décadas posteriores al comienzo de la estomatología, su evolución con variaciones en la denominación, inclusión de temáticas, ubicación en el plan de estudios e identificación de insuficiencias, presentes en la actualidad Conclusiones: A pesar del perfeccionamiento ascendente aún existen deficiencias en la enseñanza-aprendizaje de la asignatura Ortodoncia que se pueden superar al asumir lo más actual de la didáctica contemporánea.


Background: The didactics of Cuban stomatological sciences accumulates experiences that justify the current characteristics of the teaching-learning process in the subject of Orthodontics in the dentistry career. Objective: To identify the historical aspects that distinguish the process of teaching and learning in the subject of Orthodontics in Cuban stomatological education. Methodology: the analytic-synthetic method, logical and historical method and document analysis with review of medical databases of well-recognized prestige were used. Development: It was possible to establish a logical sequence of significant events in the teaching and learning of the subject of Orthodontics since its inception, four decades after the start of stomatology, its evolution with variations on the name, including themes, location in the study plan and identifying shortcomings, currently present. Conclusions: Despite the ascending improvement there are still shortcomings in the teaching and learning of the subject of Orthodontics that can be overcome by taking the most contemporary of didactic teaching today.


Assuntos
Peixes Venenosos/lesões , Intoxicação/epidemiologia , Toxicidade , Fauna Aquática , Mordeduras e Picadas/epidemiologia , Fauna Marinha
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