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1.
J Coll Physicians Surg Pak ; 33(1): 107-108, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36597245

RESUMO

Medication errors cause harm to patients at any point along the medication administration process and can be prevented. Barcoding medication administration (BCMA) is effective as a clinical decision support system (CDSS) to avoid errors. This viewpoint proposes the implementation of BCMA to avoid potential adverse events. The opinion piece gives an overview of BCMA, reviews the current literature on its effectiveness, and sheds light on the associated challenges and how to overcome them. The objective of this article is to increase awareness regarding BCMA and how it can decrease patient morbidity and mortality, enhance safety, and lower overall hospital-associated costs by preventing medication errors. Key Words: Bar-code medication administration, Medication errors, Adverse drug events, Patient safety.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Sistemas de Medicação no Hospital , Humanos , Processamento Eletrônico de Dados , Erros de Medicação/prevenção & controle , Segurança do Paciente
2.
J Patient Saf ; 19(1): 23-28, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36538338

RESUMO

OBJECTIVES: The goal of this project was to evaluate and improve the ordering, administration, documentation, and monitoring of enteral nutrition therapies within the inpatient setting in a Veteran's Health Administration system. METHODS: An interdisciplinary team of clinicians reviewed the literature for best practices and revised the process for enteral nutrition support for hospitalized veterans. Interventions included training staff, revising workflows to include scanning patients and products, including enteral nutrition orders within the medication administration record (MAR), and using the existing bar code medication administration system for administration, documentation, and monitoring. Baseline and postprocess improvement outcomes over a year period were collected and analyzed for quality improvement opportunities. RESULTS: Before process change, only 60% (33/55) of reviewed enteral nutrition orders were documented and 40% (22/55) were not documented in the intake flowsheet of the electronic health record. In the year after adding enteral nutrition therapies to the MAR and using bar code scanning, a total of 3807 enteral nutrition products were evaluated. One hundred percent of patients were bar code scanned, 3106/3807 (82%) products were documented as given, 447/3807 (12%) were documented as held (with comments), 12/3807 (<1%) were documented as missing/unavailable, and 242/3807 (6%) were documented as refused. CONCLUSIONS: Inclusion of enteral nutrition order sets on the MAR and using bar code scanning technology resulted in sustained improvements in safety, administration, and documentation of enteral therapies for hospitalized veterans.


Assuntos
Erros de Medicação , Veteranos , Humanos , Nutrição Enteral , Tecnologia , Documentação , Processamento Eletrônico de Dados/métodos , Atenção à Saúde
3.
Cir. mayor ambul ; 27(1): 3-5, oct.- dic. 2022. graf
Artigo em Espanhol | IBECS | ID: ibc-212647

RESUMO

Introducción: La valoración que el paciente hace de la atención prestada es un indicador importante de la calidad del servicio prestado, demostrando ser eficaz en la mejora continua de la calidad asistencial a fin de detectar debilidades que ayuden a desarrollar estrategias de mejora. Uno de esos medidores es el Net Promoter Score (NPS), sistema de medición que indica la probabilidad que se recomiende el servicio a un familiar o amigo. En mayo de 2021 comenzó una prueba piloto con la cual se impulsa un proceso de automatización del sistema de evaluación de la satisfacción del paciente. El objetivo de este estudio es obtener una valoración cuantificable de la satisfacción de nuestros pacientes, conociendo el NPS de nuestra unidad. Metodología: Se realizó un estudio retrospectivo de los datos obtenidos a través de las encuestas realizadas digitalmente por los pacientes en un periodo comprendido desde el 21 de mayo de 2021 al 31 de marzo de 2022. Resultados: La satisfacción global ha sido muy alta, estando el 95,4 % de los pacientes feliz. Se obtuvo un NPS de 87, lo que sitúa a nuestra unidad en datos de excelencia. Conclusiones: Las herramientas cuantitativas de medición ayudan a mantener una monitorización continua de los estándares de calidad para identificar problemas, corregirlos y/o prevenirlos. Las encuestas informatizadas deben ser eficientes, de fácil desarrollo y efectuadas con regularidad (AU)


Introduction: The patient’s evaluation of the care provided is an important indicator of the quality of the service offered, proving to be effective in the continuous improvement of the quality of care, in order to detect weaknesses that help to develop strategies for improvement. One such measure is the Net Promoter Score (NPS), a system of measurement that indicates the probability that the service will be recommended to a family member or friend. In May 2021, a pilot test will begin to drive a process of automation of the patient satisfaction evaluation system. The aim of this study is to obtain a quantifiable assessment of the satisfaction of our patients, knowing the NPS of our department. Methodology: A retrospective study was carried out of the data obtained from the surveys carried out digitally by patients in the period from 21 May 2021 to 31 March 2022. Results: Overall satisfaction was very high, with 95.4% of patients being happy, and an NPS of 87 was obtained, which places our department in a position of excellence. Conclusions: Quantitative measurement tools help to keep a continuous monitoring of quality standards in order to identify problems, correct them and/or prevent them. Computerised surveys must be efficient, easy to develop and carried out regularly (AU)


Assuntos
Humanos , Procedimentos Cirúrgicos Ambulatórios , Processamento Eletrônico de Dados , Satisfação do Paciente , Estudos Retrospectivos , Inquéritos e Questionários
4.
Rev. biol. trop ; 70(1)dic. 2022.
Artigo em Inglês | LILACS-Express | LILACS, SaludCR | ID: biblio-1387717

RESUMO

Abstract Introduction: There is low evidence of genetic diversity and hybridization processes within Crocodylus acutus and C. moreletii populations. Objetive: To evaluate genetic diversity and some phylogenetic relationships in wild and captive populations of C. acutus and C. moreletii using the Barcode of Life Data System (COX1, cytochrome C oxidase subunit 1 gene). Methods: 28 individuals phenotypically like C. acutus located in the state of Guerrero, Oaxaca and Quintana Roo were sampled, as well as animals belonging to C. moreletii located in the states of Tabasco, Campeche, and Quintana Roo. 641 base pairs of nucleotide sequence from COX1 were used to obtain the haplotype and nucleotide diversity per population, and a phylogenetic and network analysis was performed. Results: Evidence of hybridization was found by observing C. moreletti haplotypes in animals phenotypically determined as C. acutus, as well as C. acutus haplotypes in animals classified as C. moreletti. Low haplotypic diversity was observed for C. acutus (0.455 ± 0.123) and for C. moreletii (0.505 ± 0.158). A phylogenetic tree was obtained in which the sequences of C. acutus and C. moreletii were grouped into two well-defined clades. Organisms identified phenotypically as C. acutus but with C. moreletii genes were separated into a different clade within the clade of C. moreletii. Conclusions: There are reproductive individuals with haplotypes different from those of the species. This study provides a small but significant advance in the genetic knowledge of both crocodile species and the use of mitochondrial markers, which in this case, the COX1 gene allowed the detection of hybrid organisms in wild and captive populations. Conservation efforts for both species of crocodiles should prevent the crossing of both threatened species and should require the genetic identification of pure populations, to design effective conservation strategies considering the possibility of natural hybridization in areas of sympatry.


Resumen Introducción: Existe poca evidencia de la diversidad genética y los procesos de hibridación dentro de las poblaciones de Crocodylus acutus y C. moreletii. Objetivo: Evaluar la diversidad genética y algunas relaciones filogenéticas en poblaciones silvestres y cautivas de C. acutus y C. moreletii utilizando el Sistema de Código de Barras de la vida (COX1, subunidad I del gen del citocromo C oxidasa). Métodos: Se muestrearon 28 individuos fenotípicamente similares a C. acutus ubicados en los estados de Guerrero, Oaxaca y Quintana Roo, así como animales pertenecientes a C. moreletii ubicados en los estados de Tabasco, Campeche y Quintana Roo. Se utilizaron 641 pares de bases de la secuencia de nucleótidos de la subunidad I del gen del citocromo C oxidasa para obtener el haplotipo y la diversidad de nucleótidos por población, y se realizó un análisis filogenético y de redes. Resultados: Se encontró evidencia de hibridación al observar haplotipos de C. moreletti en animales determinados fenotípicamente como C. acutus, así como haplotipos de C. acutus en animales clasificados como C. moreletti. Se observó una baja diversidad haplotípica para C. acutus (0.455 ± 0.123) y para C. moreletii (0.505 ± 0.158). Se obtuvo un árbol filogenético en el que las secuencias propias de C. acutus y C. moreletii se agruparon en dos grandes y bien definidos clados. Los organismos identificados fenotípicamente como C. acutus pero con genes de C. moreletii se separaron en un clado diferente dentro del clado de C. moreletii. Conclusiones: Existen individuos reproductores con haplotipos diferentes a los de la especie. Este estudio aporta un pequeño pero significativo avance en el conocimiento genético tanto de las especies de cocodrilos como del uso de marcadores mitocondriales, que, en este caso, el gen COX1 permitió la detección de organismos híbridos en poblaciones silvestres y cautivas. Los esfuerzos de conservación para ambas especies de cocodrilos deben evitar el cruce de ambas especies amenazadas y deben requerir la identificación genética de poblaciones puras, para diseñar estrategias de conservación efectivas considerando la posibilidad de hibridación natural en áreas de simpatría.


Assuntos
Animais , Jacarés e Crocodilos/genética , México , Processamento Eletrônico de Dados
5.
Sensors (Basel) ; 22(19)2022 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-36236331

RESUMO

For the interacting with real world, augmented reality devices need lightweight yet reliable methods for recognition and identification of physical objects. In that regard, promising possibilities are offered by supporting computer vision with 2D barcode tags. These tags, as high contrast and visually well-defined objects, can be used for finding fiducial points in the space or to identify physical items. Currently, QR code readers have certain demands towards the size and visibility of the codes. However, the increase of resolution of built-in cameras makes it possible to identify smaller QR codes in the scene. On the other hand, growing resolutions cause the increase to the computational effort of tag location. Therefore, resolution reduction in decoders is a common trade-off between processing time and recognition capabilities. In this article, we propose the simulation method of QR codes scanning near limits that stem from Shannon's theorem. We analyze the efficiency of three publicly available decoders versus different size-to-sampling ratios (scales) and MTF characteristics of the image capture subsystem. The MTF we used is based on the characteristics of real devices, and it was modeled using Gaussian low-pass filtering. We tested two tasks-decoding and locating-and-decoding. The findings of the work are several-fold. Among others, we identified that, for practical decoding, the QR-code module should be no smaller than 3-3.5 pixels, regardless of MTF characteristics. We confirmed the superiority of Zbar in practical tasks and the worst recognition capabilities of OpenCV. On the other hand, we identified that, for borderline cases, or even below Nyquist limit where the other decoders fail, OpenCV is still capable of decoding some information.


Assuntos
Processamento Eletrônico de Dados , Processamento Eletrônico de Dados/métodos
6.
Stud Health Technol Inform ; 300: 19-29, 2022 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-36300399

RESUMO

The role of the field of informatics in medical imaging is vital; novel or adapted informatics' core methods can be employed to realise innovative information processing and engineering of medical images. As such, imaging informatics can assist in the interpretation of image-based, clinically recorded evidence. This, in turn, leads to the generation of associated actionable knowledge to achieve precision medicine practice. The discipline of informatics has the power to transform data to useful clinical information patterns of observable evidence and, subsequently to generate actionable knowledge in terms of diagnosis, prognosis, and disease management. This paper presents the author's personal viewpoint and distinct contributions to innovations in the acquisition and collection of imaging data; storage, retrieval, and management of imaging information objects; quantitative analysis, classification, and dissemination of imaging observable evidence.


Assuntos
Informática Médica , Diagnóstico por Imagem , Medicina de Precisão , Processamento Eletrônico de Dados , Coleta de Dados
7.
Rev. esp. quimioter ; 35(5): 492-497, Oct. 2022. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-210703

RESUMO

Introducción. La necesidad de integrar en la práctica clínica las resistencias locales es cada vez más urgente, especialmente en Atención Primaria, donde el tratamiento empírico es frecuente. Material y métodos. Se desarrolló un estudio retrospectivo observacional en el área de salud de Alcalá de Henares de los aislados microbiológicos positivos de Neisseria gonorrhoeae de cualquier localización (uretral, cervical, faríngea, rectal u orina). Se analizaron características sociodemográficas y resistencias a cefalosporinas, azitromicina, penicilina y quinolonas. Se relacionó cada aislado con su código postal de procedencia. Resultados. Se analizaron 256 muestras microbiológicas de N. gonorrhoeae, la mayoría pertenecientes a hombres (92,9%) con edad media de 33 años. La mitad de las muestras (49,8%) fueron resistentes a ciprofloxacino. La evolución temporo-espacial de las resistencias antimicrobianas se integró en mapas de calor con los códigos postales con más resistencias. Conclusión. Conocer las resistencias locales puede ayudar a pautar tratamientos empíricos más adecuados, especialmente en Atención Primaria, evitando la utilización de antibióticos inadecuados y disminuyendo las tasas de resistencias. (AU)


Introduction. The need to integrate local resistances into clinical practice is increasingly urgent, especially in Primary Care where empirical treatment is frequent. Methods. A retrospective observational study of positive microbiological isolates of Neisseria gonorrhoeae from any location (urethral, cervical, pharyngeal, rectal or urine) was carried out in the health area of Alcalá de Henares. Sociodemographic characteristics and resistance to cephalosporins, azithromycin, penicillin and quinolones were analyzed. Each isolate was related to its postal code of origin. Results. We analyzed 256 microbiological samples of N.gonorrhoeae, most of them male (92.9%) with a mean age of 33 years. Half of the samples (49.8%) were resistant to ciprofloxacin. Temporal and spatial evolution of antimicrobial resistance was integrated in heat maps. Conclusion. Knowing local resistances can help to prescribe more adequate empirical treatments, especially in Primary Care, avoiding inadequate antibiotics and decreasing resistance rates. (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Processamento Eletrônico de Dados , Neisseria gonorrhoeae , Resistência a Medicamentos , Estudos Retrospectivos , Atenção Primária à Saúde , Antibacterianos
8.
Sci Rep ; 12(1): 14925, 2022 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-36056137

RESUMO

Neuronal network computation and computation by avalanche supporting networks are of interest to the fields of physics, computer science (computation theory as well as statistical or machine learning) and neuroscience. Here we show that computation of complex Boolean functions arises spontaneously in threshold networks as a function of connectivity and antagonism (inhibition), computed by logic automata (motifs) in the form of computational cascades. We explain the emergent inverse relationship between the computational complexity of the motifs and their rank-ordering by function probabilities due to motifs, and its relationship to symmetry in function space. We also show that the optimal fraction of inhibition observed here supports results in computational neuroscience, relating to optimal information processing.


Assuntos
Neurônios , Neurociências , Computadores , Processamento Eletrônico de Dados , Aprendizado de Máquina , Neurônios/fisiologia
9.
Biosystems ; 221: 104778, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36099979

RESUMO

Basic synthetic information processing structures, such as logic gates, oscillators and flip-flops, have already been implemented in living organisms. Current implementations of these structures have yet to be extended to more complex processing structures that would constitute a biological computer. We make a step forward towards the construction of a biological computer. We describe a model-based computational design of a biological processor that uses transcription and translation resources of the host cell to perform its operations. The proposed processor is composed of an instruction memory containing a biological program, a program counter that is used to address this memory, and a biological oscillator that triggers the execution of the next instruction in the memory. We additionally describe the implementation of a biological compiler that compiles a sequence of human-readable instructions into ordinary differential equation-based models, which can be used to simulate and analyse the dynamics of the processor. The proposed implementation presents the first programmable biological processor that exploits cellular resources to execute the specified instructions. We demonstrate the application of the described processor on a set of simple yet scalable biological programs. Biological descriptions of these programs can be produced manually or automatically using the provided compiler.


Assuntos
Lógica , Software , Processamento Eletrônico de Dados , Humanos
11.
Comput Intell Neurosci ; 2022: 6394029, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35875748

RESUMO

This study studies the problem of efficient multimedia data acquisition and decreasing whole energy expenditure of wireless multimedia sensor networks and proposes a three-step multimedia data acquisition and wireless energy supplement strategy. Firstly, for network partition, this study proposes a network partition scheme based on vicinity likeness and distance of sensor nodes (VLD), which divides the whole sensor network into multiple regions. The physical links inside the region are dense and concentrated, while the link connections between regions are sparse. Disconnecting the connections between regions hardly affects the data transmission of sensor nodes. Secondly, this study proposes an efficient data acquisition and processing scheme for wireless multimedia sensor network ASS. Compared with other anchor selection schemes, this scheme has obvious performance advantages. Then, the problem of minimizing network energy expenditure is defined, and the optimal sensor node data perception rate and network link transmission rate of the optimization function are obtained by dual decomposition and sub-gradient method. Finally, in the case of a given network energy threshold, the performance of the overall strategy in this study is verified by comparing the amount of data collected by the base station.


Assuntos
Coleta de Dados , Processamento Eletrônico de Dados , Redes de Comunicação de Computadores , Coleta de Dados/métodos , Processamento Eletrônico de Dados/métodos , Multimídia , Tecnologia sem Fio
12.
Anal Chem ; 94(30): 10626-10635, 2022 08 02.
Artigo em Inglês | MEDLINE | ID: mdl-35866879

RESUMO

Barcoding and pooling cells for processing as a composite sample are critical to minimize technical variability in multiplex technologies. Fluorescent cell barcoding has been established as a standard method for multiplexing in flow cytometry analysis. In parallel, mass-tag barcoding is routinely used to label cells for mass cytometry. Barcode reagents currently used label intracellular proteins in fixed and permeabilized cells and, therefore, are not suitable for studies with live cells in long-term culture prior to analysis. In this study, we report the development of fluorescent palladium-based hybrid-tag nanotrackers to barcode live cells for flow and mass cytometry dual-modal readout. We describe the preparation, physicochemical characterization, efficiency of cell internalization, and durability of these nanotrackers in live cells cultured over time. In addition, we demonstrate their compatibility with standardized cytometry reagents and protocols. Finally, we validated these nanotrackers for drug response assays during a long-term coculture experiment with two barcoded cell lines. This method represents a new and widely applicable advance for fluorescent and mass-tag barcoding that is independent of protein expression levels and can be used to label cells before long-term drug studies.


Assuntos
Processamento Eletrônico de Dados , Corantes Fluorescentes , Linhagem Celular , Citometria de Fluxo/métodos , Corantes Fluorescentes/química , Proteômica
13.
Clin Orthop Relat Res ; 480(10): 1971-1976, 2022 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-35857333

RESUMO

BACKGROUND: The Irish National Orthopaedic Register (INOR) provides a national mechanism for managing data on THA and TKA in Ireland, including a detailed implant record populated by intraoperative implant bar code scanning. It is critically important that implant details are recorded accurately for longitudinal outcome studies, implant recalls, and revision surgery planning. Before INOR's 2014 launch, Irish hospitals maintained separate, local institutional arthroplasty databases. These individual databases typically took the form of hardcopy operating room (OR) logbooks with handwritten patient details alongside the descriptive stickers from the implant packaging and/or individual institution electronic records using manual electronic implant data input. With the introduction of the INOR, a single, unifying national database was established with the ability to instead collect implant data using bar code scanning at time of implant unpackaging in the OR. We observed that bar code data entry represented a novel and potentially substantial change to implant recording methods at our institution and so sought to examine the potential effect on implant data quality. QUESTIONS/PURPOSES: We compared the new bar code scanning method of implant data collection used by the INOR to the previously employed recording methods at our institution (in our case, the previous methods included both an electronic operation note database [Bluespier software] and a duplicate hardcopy OR logbook) and asked (1) Does bar code scanning improve the completeness of implant records? (2) Does bar code scanning improve the accuracy of implant records? METHODS: Although the INOR was launched in 2014, our institution went live with it in 2019. To avoid any potential recording issues that may have occurred during the 2019 introduction of the novel system, a clear period before the introduction of INOR was selected at our institution to represent an era of manual data input to Bluespier software: July 2018. Although we initially aimed for 2 months of data from July 1, 2018, to August 31, 2018 (n = 247), we decided to proceed to 250 consecutive, primary THAs or TKAs for clarity of results. No procedure meeting these criteria was excluded. A second recent period, January 2021, was identified to represent an era of bar code data input; 250 consecutive, primary THAs or TKAs were also included from this date (to February 15, 2021). No case meeting these criteria was excluded. A total of 4244 implant parameters from these 500 primary THAs or TKAs were manually cross-referenced for missing or incorrect data. Eleven THA and six TKA parameters were chosen for comparison, including implant names and component sizes. For each case, either the 2018 Bluespier electronic record or the 2021 INOR electronic record was manually interrogated, and implant details were recorded by two authors before they were compared against the duplicate record for every case (the reference-standard OR logbook containing the corresponding implant product stickers) for both completeness and accuracy. Completeness was defined binarily as the implant parameter being either present or absent; we did likewise for accuracy, either that parameter was correct or incorrect. The OR logbooks were chosen as the reference standard because we felt the risk of product stickers containing errors (inaccuracies) was negligible, and in our collective experience, missing stickers (incompleteness) has not been encountered. Logbook case completeness was also confirmed by comparison to our inpatient management system. RESULTS: With the introduction of the automated bar code data entry in the INOR, the proportion of missing data declined from 7% (135 of 2051) to 0% (0 of 2193), and the proportion of incorrectly recorded implant parameters declined from 2% (45 of 2051) to 0% (0 of 2193). The proportion of procedures with entirely accurate implant records rose from 53% (133 of 250) to 100% (250 of 250). CONCLUSION: The completeness and accuracy of implant data capture was improved after the introduction of a contemporary electronic national arthroplasty registry that utilizes bar code data entry. CLINICAL RELEVANCE: Based on the results of this study, other local and national registers may consider bar code data entry in the OR to achieve excellent implant data quality. Future studies may examine implant data quality at a national level to validate the bar code-populated data of the INOR.


Assuntos
Artroplastia de Quadril , Artroplastia do Joelho , Ortopedia , Artroplastia do Joelho/efeitos adversos , Processamento Eletrônico de Dados , Humanos , Sistema de Registros , Reoperação
14.
BMC Bioinformatics ; 23(1): 267, 2022 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-35804309

RESUMO

BACKGROUND: Modern mass spectrometry has revolutionized the detection and analysis of metabolites but likewise, let the data skyrocket with repositories for metabolomics data filling up with thousands of datasets. While there are many software tools for the analysis of individual experiments with a few to dozens of chromatograms, we see a demand for a contemporary software solution capable of processing and analyzing hundreds or even thousands of experiments in an integrative manner with standardized workflows. RESULTS: Here, we introduce MetHoS as an automated web-based software platform for the processing, storage and analysis of great amounts of mass spectrometry-based metabolomics data sets originating from different metabolomics studies. MetHoS is based on Big Data frameworks to enable parallel processing, distributed storage and distributed analysis of even larger data sets across clusters of computers in a highly scalable manner. It has been designed to allow the processing and analysis of any amount of experiments and samples in an integrative manner. In order to demonstrate the capabilities of MetHoS, thousands of experiments were downloaded from the MetaboLights database and used to perform a large-scale processing, storage and statistical analysis in a proof-of-concept study. CONCLUSIONS: MetHoS is suitable for large-scale processing, storage and analysis of metabolomics data aiming at untargeted metabolomic analyses. It is freely available at: https://methos.cebitec.uni-bielefeld.de/ . Users interested in analyzing their own data are encouraged to apply for an account.


Assuntos
Metabolômica , Software , Processamento Eletrônico de Dados , Espectrometria de Massas , Metabolômica/métodos , Fluxo de Trabalho
15.
J Patient Saf ; 18(6): 526-530, 2022 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-35797583

RESUMO

ABSTRACT: Medication errors are the most common type of error in hospitals and reflect a leading cause of avoidable harm to patients. Bar code medication administration (BCMA) systems are a technology designed to help intercept medication errors at the point of medication administration. This article describes the process of developing, testing, and refining a standard for BCMA adoption and use in U.S. hospitals, as measured through the Leapfrog Hospital Survey. Building on the published literature and an expert panel's collective experience in studying, implementing, and using BCMA systems, the expert panel recommended a standard with 4 key domains. Leapfrog's BCMA standard provides hospitals with a "how-to guide" on what best practice looks like for using BCMA to ensure safe medication administration at the bedside.


Assuntos
Processamento Eletrônico de Dados , Sistemas de Medicação no Hospital , Hospitais , Humanos , Pacientes Internados , Erros de Medicação/prevenção & controle
16.
Sensors (Basel) ; 22(13)2022 Jun 21.
Artigo em Inglês | MEDLINE | ID: mdl-35808167

RESUMO

Emerging Air Traffic Management (ATM) and avionics human-machine system concepts require the real-time monitoring of the human operator to support novel task assessment and system adaptation features. To realise these advanced concepts, it is essential to resort to a suite of sensors recording neurophysiological data reliably and accurately. This article presents the experimental verification and performance characterisation of a cardiorespiratory sensor for ATM and avionics applications. In particular, the processed physiological measurements from the designated commercial device are verified against clinical-grade equipment. Compared to other studies which only addressed physical workload, this characterisation was performed also looking at cognitive workload, which poses certain additional challenges to cardiorespiratory monitors. The article also addresses the quantification of uncertainty in the cognitive state estimation process as a function of the uncertainty in the input cardiorespiratory measurements. The results of the sensor verification and of the uncertainty propagation corroborate the basic suitability of the commercial cardiorespiratory sensor for the intended aerospace application but highlight the relatively poor performance in respiratory measurements during a purely mental activity.


Assuntos
Medicina Aeroespacial , Dispositivos Eletrônicos Vestíveis , Aptidão Cardiorrespiratória , Fenômenos Fisiológicos Cardiovasculares , Cognição , Processamento Eletrônico de Dados , Humanos , Fenômenos Fisiológicos Respiratórios
17.
Big Data ; 10(5): 408-424, 2022 10.
Artigo em Inglês | MEDLINE | ID: mdl-35666602

RESUMO

Multimodal Analytics in Big Data architectures implies compounded configurations of the data processing tasks. Each modality in data requires specific analytics that triggers specific data processing tasks. Scalability can be reached at the cost of an attentive calibration of the resources shared by the different tasks searching for a trade-off with the multiple requirements they impose. We propose a methodology to address multimodal analytics within the same data processing approach to get a simplified architecture that can fully exploit the potential of the parallel processing of Big Data infrastructures. Multiple data sources are first integrated into a unified knowledge graph (KG). Different modalities of data are addressed by specifying ad hoc views on the KG and producing a rewriting of the graph containing merely the data to be processed. Graph traversal and rule extraction are this way boosted. Using graph embeddings methods, the different ad hoc views can be transformed into low-dimensional representation following the same data format. This way a single machine learning procedure can address the different modalities, simplifying the architecture of our system. The experiments we executed demonstrate that our approach reduces the cost of execution and improves the accuracy of analytics.


Assuntos
Big Data , Análise de Dados , Processamento Eletrônico de Dados , Aprendizado de Máquina , Armazenamento e Recuperação da Informação
18.
Gerokomos (Madr., Ed. impr.) ; 33(2): 119-126, jun. 2022. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-210353

RESUMO

La enfermedad arterial periférica es uno de los principales factores que intervienen en la aparición de la úlcera de etiología isquémica de la extremidad inferior en mayores de 70 años. La aparición de esta patología conlleva un aumento de la mobimortalidad e, incluso, llega a afectar a la calidad de vida de la persona que la padece. Todo esto hace que sea necesario aplicar métodos diagnósticos que permitan establecer un diagnóstico temprano. Para ello, se lleva a cabo una exploración clínica inicial y una exploración hemodinámica mediante el cálculo del índice tobillo-brazo. El método que se considera como el gold standard es la técnica Doppler, sin embargo, el tiempo que conlleva su realización y la necesidad de un entrenamiento previo ha dificultado su práctica en atención primaria. Como solución a esto, se ha propuesto la sustitución del método tradicional por equipos oscilométricos automáticos. Para poder determinar la fiabilidad de los dispositivos automáticos en la determinación del índice tobillo-brazo se ha realizado una revisión sistemática de la literatura científica en las bases de datos: MEDLINE, SciELO, Cochrane, Elsevier y CUIDEN hasta febrero de 2020. Se obtuvo un total de 58 artículos, de los cuales se incluyeron 15 en el análisis. Los resultados publicados son varios debido a las diferentes metodologías empleadas, los perfiles de los pacientes seleccionados para el estudio y los diversos modelos de oscilometría estudiados en cada artículo. Por tanto, las diferencias encontradas en los artículos dificultan la realización de una comparación válida entre ellos, para poder determinar qué dispositivo automático sería el más fiable en el cálculo del índice tobillo-brazo en comparación con la técnica Doppler; y se recomienda que se continúen realizando investigaciones con un diseño más centrado que permita determinar una alternativa eficaz al método tradicional en la práctica clínica (AU)


Peripheral artery disease is one of the main factors involved in the onset of ischemic etiology ulcers of the lower limb in patients older than 70 years old. The appearance of this disease leads to an increase in the morbidity and mortality and even affects the quality of life of the person who suffers from this disease. All this makes it necessary to apply diagnostic methods to make an early diagnosis. To this end, an initial clinical examination and a hemodynamic examination are carried out by calculating the ankle-brachial index (ABI). The method that is considered the gold standard is the Doppler technique. However, the time involved in its implementation and the need for prior training has hampered its practice in primary care. As a solution to this, automatic oscillometric devices that measure blood pressure have been proposed to replace the traditional method. In order to determine the reliability of automatic devices when it comes to determining the ankle-brachial index, a systematic review of scientific literature databases has been performed: MEDLINE, SciELO, Cochrane, Elsevier and CUIDEN until February 2020. A total of 58 items were received, 15 of which were included for the analysis. Several published results are due to the different methodologies employed, profiles of patients selected for the study and various models of oscillometry studied in each article. Therefore, the differences found in the articles make it difficult to make a fair comparison between them in order to determine which device would be the most reliable in determining the ankle-brachial index compared to the Doppler technique; recommending the continuous designfocused research in order to establish an effective alternative to the traditional method in clinical practice (AU)


Assuntos
Humanos , Índice Tornozelo-Braço/métodos , Processamento Eletrônico de Dados , Reprodutibilidade dos Testes
20.
Nat Commun ; 13(1): 2971, 2022 05 27.
Artigo em Inglês | MEDLINE | ID: mdl-35624112

RESUMO

Spatial transcriptomics is a powerful and widely used approach for profiling the gene expression landscape across a tissue with emerging applications in molecular medicine and tumor diagnostics. Recent spatial transcriptomics experiments utilize slides containing thousands of spots with spot-specific barcodes that bind RNA. Ideally, unique molecular identifiers (UMIs) at a spot measure spot-specific expression, but this is often not the case in practice due to bleed from nearby spots, an artifact we refer to as spot swapping. To improve the power and precision of downstream analyses in spatial transcriptomics experiments, we propose SpotClean, a probabilistic model that adjusts for spot swapping to provide more accurate estimates of gene-specific UMI counts. SpotClean provides substantial improvements in marker gene analyses and in clustering, especially when tissue regions are not easily separated. As demonstrated in multiple studies of cancer, SpotClean improves tumor versus normal tissue delineation and improves tumor burden estimation thus increasing the potential for clinical and diagnostic applications of spatial transcriptomics technologies.


Assuntos
Processamento Eletrônico de Dados , Transcriptoma , Análise por Conglomerados , Modelos Estatísticos
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