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J Photochem Photobiol B ; 223: 112298, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34474299


In this paper, the photodynamic effect of a ternary nanocomposite (TiO2-Ag/graphene) on Escherichia coli bacteria and two human cell lines: A375 (melanoma) and HaCaT (keratinocyte) after exposure to different wavelength domains (blue, green or red-Light Emitting Diode, LED) was analyzed. The results obtained through bioassays were correlated with the morphological, structural and spectral data obtained through FT-IR, XPS and UV-Vis spectroscopy, powder X-Ray diffractometry (XRD) and STEM/EDX techniques, leading to conclusions that showed different photodynamic activation mechanisms and effects on bacteria and human cells, depending on the wavelength. The nanocomposite proved a therapeutic potential for blue light-activated antibacterial treatment and revealed a keratinocyte cytotoxic effect under blue and green LEDs. The red light-nanocomposite duo gave a metabolic boost to normal keratinocytes and induced stasis to melanoma cells. The light and nanocomposite combination could be a potential therapy for bacterial keratosis or for skin tumors.

Escherichia coli/efeitos da radiação , Grafite/química , Luz , Nanocompostos/toxicidade , Sobrevivência Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos da radiação , Testes de Sensibilidade a Antimicrobianos por Disco-Difusão , Humanos , Queratinócitos/citologia , Queratinócitos/metabolismo , Queratinócitos/patologia , Queratinócitos/efeitos da radiação , Ceratose/tratamento farmacológico , Ceratose/patologia , Nanocompostos/química , Nanocompostos/uso terapêutico , Prata/química , Titânio/química
BMJ Case Rep ; 14(8)2021 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-34417235


Ichthyosis prematurity syndrome (IPS) is a rare disorder of autosomal recessive inheritance. The cardinal features include prematurity, vernix like hyperkeratosis, eosinophilia and neonatal asphyxiation. This case report discusses the presentation and management of IPS. We aim to characterise the common features, the spectrum of disease within a single family and discuss a potential role for low-dose dexamethasone in the management of ventilator-dependent patients with IPS.

Ictiose , Doenças do Prematuro , Ceratose , Dexametasona/uso terapêutico , Humanos , Recém-Nascido , Doenças do Prematuro/tratamento farmacológico
J Fam Pract ; 70(5): 249-251, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34410917


An untreated infection led to a series of unusual signs and symptoms that included difficulty walking.

Artralgia/etiologia , Exantema/etiologia , Ceratose/diagnóstico , Artrite Reativa/complicações , Artrite Reativa/diagnóstico , Pé/fisiologia , Pé/fisiopatologia , Humanos , Ceratose/complicações , Posição Genupeitoral , Masculino , Adulto Jovem
J Laryngol Otol ; 135(9): 759-764, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34348811


OBJECTIVE: This study aimed to examine the medical literature regarding the natural history and management of keratosis obturans. METHOD: PubMed was queried via the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol, and the methodological quality of each study was assessed using the Methodological Index for Non-Randomized Studies criteria. RESULTS: Fifty-one studies were abstracted, and dual investigator screening resulted in five retrospective studies for final analysis. All studies included patients afflicted with either unilateral (n = 75) or bilateral keratosis obturans (n = 8). The definition of keratosis obturans was present in three studies: a desquamated keratin plug within the external auditory canal. Mean and median Methodological Index for Non-Randomized Studies scores were 9.5 and 9.5, respectively. All patients underwent keratosis obturans exenteration with microscopy. Two studies reported an outcome instrument to evaluate endpoints: marked stillette and audiometry. No complications were observed with follow-up periods from 3 weeks to 3.5 years. CONCLUSION: This comprehensive review highlights a lack of published evidence relating to keratosis obturans. However, it appears keratosis obturans treatment is safe and efficacious with identifiable clinical practice patterns.

Otopatias/cirurgia , Ceratose/cirurgia , Procedimentos Cirúrgicos Otológicos/métodos , Meato Acústico Externo/cirurgia , Humanos , Estudos Retrospectivos , Resultado do Tratamento
Pediatr Dermatol ; 38(5): 1340-1341, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34409653


A 7-year-old healthy girl presented with an 11-month history of an asymptomatic red, dome-shaped papule on her right medial elbow and 6-month history of linearly distributed, few millimeter, flesh-colored papules extending from and including the red papule. Histopathology demonstrated features of both a Spitz nevus and lichen striatus. The Spitz nevus was removed with a punch biopsy and the lichen striatus subsequently resolved. To our knowledge, co-localization of a Spitz nevus with lichen striatus has not been previously reported and highlights the potential association between the immunogenicity of Spitz nevi and the development of lichen striatus.

Ceratose , Nevo de Células Epitelioides e Fusiformes , Nevo , Dermatopatias Papuloescamosas , Neoplasias Cutâneas , Criança , Diagnóstico Diferencial , Feminino , Humanos , Nevo de Células Epitelioides e Fusiformes/diagnóstico , Pele , Neoplasias Cutâneas/diagnóstico
J Am Podiatr Med Assoc ; 111(3)2021 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-34144595


BACKGROUND: Many people experience gastrocnemius tightness. Few studies demonstrate the relationship between gastrocnemius tightness and forefoot pathology. This study aimed to define the association between intractable plantar keratosis of the second rocker (IPK2) (also known as well-localized IPK or discrete keratosis) and metatarsalgia. METHODS: The Silfverskiöld (ST) and lunge (LT) tests, used for measuring ankle dorsiflexion, were applied to diagnose gastrocnemius tightness. An instrument for measuring accurate performance and the force to be applied (1.7-2.0 kg of force to the ankle dorsiflexion) complemented the ST for clinical diagnosis and to obtain repeatedly reliable results (the authors apply force manually, which is difficult to quantify accurately). RESULTS: Of 122 patients studied, 74 were used to devise a prediction model from a logistic regression analysis that determines the probability of presenting gastrocnemius tightness in each test (LT and ST) with the following variables: metatarsalgia, IPK2, and maximum static pressure (baropodometry). The IPK2 plays the principal role in predicting this pathology, with the highest Wald values (6.611 for LT and 5.063 for ST). Metatarsalgia induces a somewhat lower change (66.7% LT and 64.3% ST). The maximum pressure of the forefoot is equally significant (P = .043 LT and P = .025 ST), taking α < .05 as the significance level. CONCLUSIONS: The results of this validation report confirm that a model composed of metatarsalgia, IPK2, and maximum pressure in static acts as a predictive method for gastrocnemius tightness.

Contratura , Ceratose , Metatarsalgia , , Humanos , Metatarsalgia/diagnóstico , Metatarsalgia/etiologia , Músculo Esquelético
J Dtsch Dermatol Ges ; 19(10): 1518-1520, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34164922
Ann Acad Med Singap ; 50(3): 289-290, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33855333

Ceratose , Mamilos , Humanos
J Foot Ankle Res ; 14(1): 30, 2021 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-33849632


BACKGROUND: An intractable plantar keratoma (IPK) is a conical thickening of the epidermis' stratum corneum and a common cause of foot pain which can have a significant, detrimental impact on the mobility, quality of life and independence of individuals. Conservative treatments are currently offered to patients with IPK, but they are unsatisfactory since they do not offer a sufficient or permanent reduction of symptoms. The purpose of this study was the evaluation of the feasibility, safety and effectiveness of innovative treatments for intractable plantar keratoma (IPK). METHODS: A randomized single blind trial with 40 patients divided with block randomization in four parallel groups was conducted to compare treatment combinations: conservative sharp debridement only or sharp debridement with needle insertion, physiological water injection or lidocaine injection. All patients obtained the same treatment four times at a four-week interval. At each visit, visual analog scale (VAS), Foot Function Index (FFI) and IPK size were evaluated. VAS and FFI were also completed at a six and twelve-month follow-up. RESULTS: Our findings in regards to feasibility demonstrated recruitment challenges because of the anticipated pain that would be provoked by needle insertion may not be worth the potential pain relief compared to debridement alone from the patient's perspective. This was also the principal cause of drop out. Our preliminary results show no main effect of group for any of the clinical outcomes: pain felt on VAS, FFI score, IPK's size (p > 0.05). However, the analysis revealed a statistically significant effect of time on VAS (p < 0.001), FFI score (p < 0.001) and IPK's size (width and depth (p < 0.001); length (p = 0.001)), but no group x time interaction was found (p > 0.05). CONCLUSIONS: This study demonstrates that IPK treatment consisting of sharp debridement with needle insertion, physiological saline water injection or lidocaine injection is feasible and safe. There was a non-statistically significant trend toward diminishing pain intensity compared to scalpel debridement alone. The pain provoked by needle insertion and injection treatments must be addressed with a scientifically proven protocol to make it more comfortable for patients before these treatments could be considered in further studies. TRIAL REGISTRATION:, NCT04777227 . 2 March, 2021 - Retrospectively registered (All participants were recruited prior to registration).

Anestésicos Locais/administração & dosagem , Calosidades/terapia , Desbridamento/métodos , Ceratose/terapia , Lidocaína/administração & dosagem , Águas Salinas/administração & dosagem , Idoso , Desbridamento/instrumentação , Estudos de Viabilidade , Feminino , Humanos , Injeções , Masculino , Pessoa de Meia-Idade , Medição da Dor , Dor Processual/etiologia , Dor Processual/prevenção & controle , Método Simples-Cego , Resultado do Tratamento
Actas Dermosifiliogr ; 112 Suppl 1: 12, 2021 Jul.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-33905716

Ceratose , Pitiríase , Humanos , Pele