Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 20
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Sci Rep ; 12(1): 7130, 2022 05 03.
Artigo em Inglês | MEDLINE | ID: mdl-35504894

RESUMO

A study of the 4-day rhythm of the proliferative activity of the embryonic fibroblast-like cells in the logarithmic growth phase was carried out. It was shown that in cell cultures obtained on different days from embryos of different ages, the phase of the 4-day rhythm coincides. In vitro the maxima of the proliferative activity were consistent with the minima of the motor activity of mice. Freezing the culture for 2 or 6 days does not cause a shift in the phase of the 4-day rhythm of cell proliferative activity compare with the unfreezing culture. That indicates the existence of an external synchronizer, which determines the 4-day infradian rhythm of the proliferative activity of embryonic cells. Then we daily thawed samples of single L929 culture of mice fibroblast-like cells for 22 and 17 days and researched the dynamics of its proliferative activity. We also showed 4-day rhythm of the simultaneous increase in the number of cells for all thawed samples. Taking into account that deep freezing of a culture leads to the cessation of all life processes, the fact we obtained indicates an exogenous mechanism of the formation of about a 4-day rhythm of the proliferative activity of cell culture. Variations of the Earth's magnetic field could be one of the external synchronizers of the infradian rhythm. We studied the increase in number of L929 cell in conditions of a magnetic permalloy screen and showed that the magnetic shielding no affect the parameters of the infradian rhythm of L929 cell proliferative activity. So further searches of the external synchronizers are need.


Assuntos
Ritmo Circadiano , Ritmo Infradiano , Animais , Técnicas de Cultura de Células , Fibroblastos , Campos Magnéticos , Camundongos
2.
Bull Exp Biol Med ; 172(5): 592-597, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35352252

RESUMO

The study compared the daily mean intensity of one-minute-step fluctuations in intensity of the secondary cosmic rays reflected by neutron count rate and dynamics of body temperature, motor activity, as well as concentration of glucocorticoid hormones in birds and rodents. A positive correlation was established between body temperature oscillations and neutron count rate fluctuations. A similar correlation was observed between physical parameter (neutron count rate), on the one hand, and daily mean motor activity and concentration of glucocorticoid hormones in the animals. The periods and phases of these processes presented in synchronous time series coincided. The facts of simultaneous variations or disturbances of the periods in dynamics of biological and physical parameters attest to their relationships. The study concluded that the infradian rhythms with the periods of 3-5 days depend on some external environmental factor related to fluctuations in intensity of secondary cosmic rays.


Assuntos
Ritmo Infradiano , Animais , Aves , Temperatura Corporal , Ritmo Circadiano , Glucocorticoides , Atividade Motora
3.
J Biol Rhythms ; 37(1): 29-42, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-34781753

RESUMO

Work in recent years has provided strong evidence for the modulation of memory function and neuroplasticity mechanisms across circadian (daily), ultradian (shorter-than-daily), and infradian (longer-than-daily) timescales. Despite rapid progress, however, the field has yet to adopt a general framework to describe the overarching role of biological rhythms in memory. To this end, Iyer and colleagues introduced the term iterative metaplasticity, which they define as the "gating of receptivity to subsequent signals that repeats on a cyclic timebase." The central concept is that the cyclic regulation of molecules involved in neuroplasticity may produce cycles in neuroplastic capacity-that is, the ability of neural cells to undergo activity-dependent change. Although Iyer and colleagues focus on the circadian timescale, we think their framework may be useful for understanding how biological rhythms influence memory more broadly. In this review, we provide examples and terminology to explain how the idea of iterative metaplasticity can be readily applied across circadian, ultradian, and infradian timescales. We suggest that iterative metaplasticity may not only support the temporal niching of neuroplasticity processes but also serve an essential role in the maintenance of memory function.


Assuntos
Ritmo Infradiano , Ritmo Circadiano/fisiologia , Plasticidade Neuronal
4.
Bull Exp Biol Med ; 172(2): 210-213, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34853969

RESUMO

We studied the dynamic of proliferative activity of cultured mouse transformed fibroblast-like L-929 cells in the logarithmic growth phase. During a long period (December 5-23, 2020), we revealed a 4-day rhythm of daily increase in the number of L-929 cells with an amplitude not lower than in a culture of embryonic fibroblast-like cells. Hence, the formation of the 4-day rhythm is not associated with the molecular mechanisms of inhibition of proliferation, which are absent in transformed cells. Daily thawing of samples of one culture over 17 days showed the presence of a 4-day rhythm synchronous between all thawed samples and the control cell culture. As deep freezing leads to the cessation of all life processes in cells, the formation of a 4-day rhythm of proliferative activity of cell culture is determined by an exogenous mechanism.


Assuntos
Fibroblastos/fisiologia , Ritmo Infradiano/fisiologia , Animais , Contagem de Células , Divisão Celular/fisiologia , Linhagem Celular Transformada , Proliferação de Células , Ritmo Circadiano/fisiologia , Fibroblastos/citologia , Camundongos , Fatores de Tempo
5.
Bull Exp Biol Med ; 170(6): 795-798, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33893955

RESUMO

The study examined the infradian rhythms in total motor activity and the periods of "freerunning" circadian rhythm in male C57BL/6 mice and European greenfinch Chloris chloris exposed to constant light. In birds and mice, the motor activity was characterized with inphase 4-day-long rhythm. The periods of free-running circadian rhythms in birds and mice were 23 and 25 h, respectively, and they were modulated with 4-day-long periodicity. The maximal deviations in the period of free-running circadian rhythm from the individual mean levels coincided with the acrophase of 4-day-long rhythm of motor activity in both species.


Assuntos
Ritmo Circadiano/fisiologia , Animais , Aves , Ritmo Infradiano/fisiologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Atividade Motora/fisiologia
6.
J Biol Rhythms ; 36(2): 160-168, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33446001

RESUMO

Evidence has accumulated over the years indicating that the moon influences some aspects of the reproductive activity in animals and humans. However, little is known about the influence of the lunar cycle on the reproductive performance of cows under tropical conditions, where the environment strongly affects reproduction. This retrospective study was conducted with the aim of assessing the influence of the lunar cycle on some reproductive traits of tropical crossbred cows managed in a pasture-based system. Data from 5869 reproductive records from two commercial farms localized in the Maracaibo Lake Basin of Zulia State, Venezuela, were analyzed. Variables studied were first service conception rate, calving frequency, first postpartum estrous frequency, and pregnancy frequency. In addition to the lunar cycle, the effects of farm, season, and predominant breed were also considered. Data were analyzed using logistic regression and general linear model from SAS. First service conception was affected by lunar phases and predominant breed, but not by farm or season. For frequencies of calving, first postpartum estrus, and pregnancy, there was no main effect of farm, season, and predominant breed, whereas the effect of lunar phases was highly significant. First service conception was significantly greater in waning than in crescent phase of the lunar cycle. Frequencies of calving, first estrus, and pregnancy were highly correlated and showed greater figures around full moon and new moon. In conclusion, lunar cycle influenced first service conception, attaining greater values in the waning phase of the moon cycle. Frequencies of calving, first postpartum estrus, and pregnancy in crossbred cows showed a clear bimodal rhythm, whose greatest values coincided with new moon and full moon.


Assuntos
Cruzamento , Bovinos/fisiologia , Ritmo Infradiano , Lua , Reprodução/fisiologia , Clima Tropical , Animais , Estro , Feminino , Masculino , Gravidez , Estudos Retrospectivos
7.
Bull Exp Biol Med ; 169(5): 714-717, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32986210

RESUMO

We studied daily dynamics of proliferative activity of embryonic fibroblast-like cells in culture during the logarithmic growth phase. Daily increase in cell count in the culture showed a 4-day rhythm that persisted over 3 weeks of culturing. In cultures from different animals, the phase of this rhythm was synchronous and did not depend on the moment of cell isolation. It can be hypothesized that the 4-day biorhythm of proliferative activity of embryonic fibroblast-like cells in culture is determined by external environmental factors, probably of electromagnetic nature.


Assuntos
Proliferação de Células/fisiologia , Fibroblastos/metabolismo , Ritmo Infradiano/fisiologia , Animais , Corticosterona/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , Periodicidade
8.
Am J Hypertens ; 33(8): 687-694, 2020 08 04.
Artigo em Inglês | MEDLINE | ID: mdl-32198504

RESUMO

Salt (NaCl) is a prerequisite for life. Excessive intake of salt, however, is said to increase disease risk, including hypertension, arteriosclerosis, heart failure, renal disease, stroke, and cancer. Therefore, considerable research has been expended on the mechanism of sodium handling based on the current concepts of sodium balance. The studies have necessarily relied on relatively short-term experiments and focused on extremes of salt intake in humans. Ultra-long-term salt balance has received far less attention. We performed long-term salt balance studies at intakes of 6, 9, and 12 g/day and found that although the kidney remains the long-term excretory gate, tissue and plasma sodium concentrations are not necessarily the same and that urinary salt excretion does not necessarily reflect total-body salt content. We found that to excrete salt, the body makes a great effort to conserve water, resulting in a natriuretic-ureotelic principle of salt excretion. Of note, renal sodium handling is characterized by osmolyte excretion with anti-parallel water reabsorption, a state-of-affairs that is achieved through the interaction of multiple organs. In this review, we discuss novel sodium and water balance concepts in reference to our ultra-long-term study. An important key to understanding body sodium metabolism is to focus on water conservation, a biological principle to protect from dehydration, since excess dietary salt excretion into the urine predisposes to renal water loss because of natriuresis. We believe that our research direction is relevant not only to salt balance but also to cardiovascular regulatory mechanisms.


Assuntos
Água Corporal/metabolismo , Sistema Cardiovascular/metabolismo , Rim/metabolismo , Fígado/metabolismo , Eliminação Renal/fisiologia , Sódio/metabolismo , Equilíbrio Hidroeletrolítico/fisiologia , Animais , Apetite , Ingestão de Líquidos , Metabolismo Energético , Humanos , Ritmo Infradiano/fisiologia , Capacidade de Concentração Renal/fisiologia , Músculo Esquelético/metabolismo , Natriurese/fisiologia , Cloreto de Sódio na Dieta/metabolismo , Sede
9.
Mol Brain ; 12(1): 107, 2019 12 10.
Artigo em Inglês | MEDLINE | ID: mdl-31822292

RESUMO

Bipolar disorder is a major mental illness characterized by severe swings in mood and activity levels which occur with variable amplitude and frequency. Attempts have been made to identify mood states and biological features associated with mood changes to compensate for current clinical diagnosis, which is mainly based on patients' subjective reports. Here, we used infradian (a cycle > 24 h) cyclic locomotor activity in a mouse model useful for the study of bipolar disorder as a proxy for mood changes. We show that metabolome patterns in peripheral blood could retrospectively predict the locomotor activity levels. We longitudinally monitored locomotor activity in the home cage, and subsequently collected peripheral blood and performed metabolomic analyses. We then constructed cross-validated linear regression models based on blood metabolome patterns to predict locomotor activity levels of individual mice. Our analysis revealed a significant correlation between actual and predicted activity levels, indicative of successful predictions. Pathway analysis of metabolites used for successful predictions showed enrichment in mitochondria metabolism-related terms, such as "Warburg effect" and "citric acid cycle." In addition, we found that peripheral blood metabolome patterns predicted expression levels of genes implicated in bipolar disorder in the hippocampus, a brain region responsible for mood regulation, suggesting that the brain-periphery axis is related to mood-change-associated behaviors. Our results may serve as a basis for predicting individual mood states through blood metabolomics in bipolar disorder and other mood disorders and may provide potential insight into systemic metabolic activity in relation to mood changes.


Assuntos
Afeto , Transtorno Bipolar/sangue , Transtorno Bipolar/metabolismo , Metaboloma , Fatores de Transcrição ARNTL/genética , Fatores de Transcrição ARNTL/metabolismo , Animais , Transtorno Bipolar/genética , Transtorno Bipolar/fisiopatologia , Modelos Animais de Doenças , Regulação da Expressão Gênica , Hipocampo/metabolismo , Ritmo Infradiano/genética , Masculino , Camundongos , Mitocôndrias/metabolismo , Atividade Motora/genética
10.
Bull Exp Biol Med ; 168(2): 291-294, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31782004

RESUMO

The rhythms of short-term arousal episodes, associated with normalization of low body temperature, were studied in hibernating Erinaceus roumanicus. The episodes of body temperature recovery during hibernation were 1.7 times more incident during the acrophase of 4.058-day rhythm of glucocorticoid hormones, detected previously, than during the batiphase of this rhythm. Ultradian rhythm of arousal episodes conformed to a 4-h biorhythm: the maximum number of body temperature resumption episodes was recorded at 00.00-01.00, 04.00-05.00, 08.00-09.00, 12.00-13.00, 16.00-17.00, and 20.00-21.00. These data indicated that in mammals the mechanisms of infradian and ultradian rhythm maintenance were stable and did not depend on body temperature or were determined by external factors with periods of 4.058 days and 4 h.


Assuntos
Temperatura Corporal/fisiologia , Ritmo Circadiano/fisiologia , Ouriços/fisiologia , Hibernação/fisiologia , Ritmo Infradiano/fisiologia , Ritmo Ultradiano/fisiologia , Animais , Relógios Biológicos/fisiologia , Estações do Ano
11.
Curr Biol ; 29(20): 3501-3509.e5, 2019 10 21.
Artigo em Inglês | MEDLINE | ID: mdl-31607536

RESUMO

Synchronizing the annual timing of physiological, morphological, and behavioral transitions with seasons enables survival in temperate environments [1]. The capacity to adjust life history timing and track local seasonal cycles can facilitate geographic expansion [2], adaptation [3], and tolerance [4-6] during rapid environmental change. Understanding the proximate causes of variation in seasonal timing improves prediction of future response and persistence [7, 8]. However, relatively little is known about the molecular basis generating this diversity [9], particularly in Lepidoptera, a group with many species in decline [10, 11]. In insects, the stress-tolerant physiological state of diapause enables coping with seasonal challenges [1, 12-15]. Seasonal changes in photoperiod and temperature are used to synchronize diapause with winter, and timing of diapause transitions varies widely within and among species [9, 16]. Changes in spring diapause termination in the European corn borer moth (Ostrinia nubilalis) have allowed populations to respond to shorter winters and emerge ∼3 weeks earlier in the year [17]. Multiple whole-genome approaches suggest two circadian clock genes, period (per) and pigment-dispersing factor receptor (Pdfr), underlie this polymorphism. Per and Pdfr are within interacting quantitative trait loci (QTL) and differ in allele frequency among individuals that end diapause early or late, with alleles maintained in high linkage disequilibrium. Our results provide testable hypotheses about the physiological role of circadian clock genes in the circannual timer. We predict these gene candidates will be targets of selection for future adaptation under continued global climate change [18].


Assuntos
Genoma de Inseto/fisiologia , Mariposas/genética , Animais , Genômica , Ritmo Infradiano/genética , Fatores de Tempo
12.
Sci Rep ; 9(1): 5988, 2019 04 12.
Artigo em Inglês | MEDLINE | ID: mdl-30979936

RESUMO

The spermatozoon must be physiologically prepared to fertilize the egg, process called capacitation. Human sperm samples are heterogeneous in their ability to capacitate themselves, which leads to variability between samples from the same or different donors, and even along the seasons. Here we studied sperm variation in the capacitation state according to the ability of capacitated spermatozoa to acrosome react upon stimulation (% ARi) and to be recruited by chemotaxis (% Chex). Both indirect indicators of sperm capacitation increased along the incubation time with fluctuations. Those capacitated sperm recruited by chemotaxis showed an ultradian rhythm with a cycle every 2 h, which might be influenced by unknown intrinsic sperm factors. Two infradian rhythms of 12 months for the % ARi and of 6 months for % Chex were observed, which are associated with the joint action of temperature and photoperiod. Thus, to avoid false negative results, human sperm samples are recommended to be incubated for a long period (e.g. 18 h) preferably in spring time. This innovative point of view would lead to better comprehend human reproductive biology and to think experimental designs in the light of sperm cyclicity or to improve sperm aptitude for clinical purposes.


Assuntos
Ritmo Infradiano/fisiologia , Espermatozoides/fisiologia , Ritmo Ultradiano/fisiologia , Cálcio/metabolismo , Humanos , Espaço Intracelular/metabolismo , Masculino , Potenciais da Membrana , Espermatozoides/citologia
13.
J Biol Rhythms ; 34(1): 19-38, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30793651

RESUMO

In situ activity patterns of 2 Formica rufa-group species ( F. pratensis; F. polyctena) were continuously studied at 4 different red wood-ant nests for 6 months in each of the years 2010, 2011, 2012, and 2016 and related to weather factors and variations in the Earth's magnetic field. The in situ activity patterns of both species were similarly periodic and exhibited ultradian, and short- and long infradian rhythms under natural LD conditions. Crepuscular and nocturnal activities shorter than or equal to 4 h were observed in both species, especially at the new moon and first quarter after the astronomical twilight in a period of darkness in fall. We hypothesize that local variability in the Earth's magnetic field affects these long-term activity patterns, whereas humidity and temperature were more strongly associated with ultradian rhythms (less than 20 h).


Assuntos
Formigas/fisiologia , Escuridão , Ritmo Infradiano , Locomoção , Ritmo Ultradiano , Animais , Comportamento Animal , Umidade , Campos Magnéticos , Estações do Ano , Temperatura
14.
Bull Exp Biol Med ; 166(3): 413-416, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30617706

RESUMO

Daily dynamics of changes in the latency of a response to dissociative anesthetic tiletamine (time from injection to ataxia) was studied in mature Wistar rats. Both intramuscular and intravenous administration of the anesthetic was associated with 4-day oscillations of the latent period synchronous with the dynamics of changes in the concentration of glucocorticoid hormones. The period and phases of the infradian rhythm of resistance to the anesthetic remained unchanged after removal of both adrenal glands and testes and administration of corticosterone synthesis blocker trilostane diminishing the 4-day cycle of changes in corticosterone level. Therefore, hormones of the adrenal glands and testes do not play the key role in the mechanisms of formation of the 4-day infradian rhythm.


Assuntos
Anestésicos Dissociativos/farmacologia , Corticosterona/biossíntese , Resistência a Medicamentos/fisiologia , Ritmo Infradiano/efeitos dos fármacos , Tiletamina/farmacologia , Glândulas Suprarrenais/metabolismo , Glândulas Suprarrenais/cirurgia , Adrenalectomia , Animais , Corticosterona/antagonistas & inibidores , Di-Hidrotestosterona/análogos & derivados , Di-Hidrotestosterona/farmacologia , Inibidores Enzimáticos/farmacologia , Ritmo Infradiano/fisiologia , Injeções Intramusculares , Injeções Intravenosas , Masculino , Orquiectomia , Ratos , Ratos Wistar , Testículo/metabolismo , Testículo/cirurgia
15.
Bone ; 120: 403-410, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30503954

RESUMO

Recent studies have indicated that there may be an infradian systemic biorhythm that coordinates aspects of human hard tissue growth and influences adult body size. Here we investigate if evidence of this biorhythm retained in human teeth as the periodicity of Retzius lines (RP) corresponds with the microstructural growth of a non-weight bearing bone, the rib, in a sample of 50 human juvenile skeletons. Using static histomorphometric methods, the RP of one permanent tooth from each skeleton was calculated and combined with measures of bone remodeling in a rib from the same individual. Results provide the first evidence that the infradian biorhythm is linked to bone remodeling in children. Retzius periodicity was negatively correlated with relative osteon area (r = -0.563, p = 0.008) and positively related to Haversian canal area (r = 0.635, p = 0.002) and diameter (r = 0.671, p = 0.001) in children between the age of 8 to 12 years. There was also a negative correlation between RP and the relative cortical area of ribs (r = -0.500, p = 0.048). Relationships between bone remodeling and the biorhythm were much more variable in younger children. Results imply that as the biorhythm speeds up there is increased bone deposition during remodeling of the rib, leading to the larger osteonal lamellar bone areas and smaller Haversian canals in children between 8 and 12 years of age. Our results support the idea that there is an infradian biorhythm that coordinates aspects of human hard tissue growth.


Assuntos
Ritmo Infradiano/fisiologia , Microscopia/métodos , Costelas/fisiologia , Adolescente , Remodelação Óssea/fisiologia , Feminino , Ósteon/anatomia & histologia , Humanos , Modelos Lineares , Masculino , Costelas/anatomia & histologia
16.
Bull Exp Biol Med ; 165(2): 276-279, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29931631

RESUMO

The numerical density of secretory granules dense-core vesicles (DCV) in the cytoplasm of pinealocytes of the pineal gland was estimated by transmission electron microscopy in male white mice and Wistar rats. The 3-day biorhythm and lunaphase changes in the DCV content in the perikaryon and the processes of pinealocytes, which are manifested significantly in different seasons of the year, are established. The three-day biorhythm in adult male mice in comparison with younger male rats is not expressed uniformly in different phases of the moon. The in-phase manifestation of infradian biorhythms in different species of animals during the year with an unchanged daily photophase indicates the existence of common external synchronizers for mammals of these biorhythms that are not associated with the light/dark cycle.


Assuntos
Ritmo Infradiano/fisiologia , Glândula Pineal/citologia , Glândula Pineal/metabolismo , Vesículas Secretórias/metabolismo , Animais , Citoplasma/metabolismo , Citoplasma/ultraestrutura , Masculino , Camundongos , Fotoperíodo , Ratos , Ratos Wistar , Estações do Ano
17.
Bull Exp Biol Med ; 163(5): 687-690, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28944424

RESUMO

The relationship between the phase of 4-day serum corticosteroid biorhythm and resistance to acute hypobaric hypoxia was studied in male rats. Single evaluations of hypoxic resistance of Wistar rats during the same time of the day have shown that the lifespan of animals is significantly longer during the 4-day biorhythm acrophase than during the bathyphase. Daily testing for 12 days has detected a 4-day rhythm of hypoxic resistance, synphasic with corticosterone biorhythm, irrespective of the wave-like course of the adaptation process phase from the beginning of daily testing and hypoxic resistance. Experiments on Sprague-Dawley rats have shown that animals highly resistant and medium resistant to hypoxia during the infradian biorhythm acrophase become medium resistant and poorly resistant during the bathyphase. In order to detect the animals with the least hypoxic resistance in the population, the studies should be carried out during the 4-day infradian biorhythm acrophase, while detection of the most resistant animals should be carried out during the bathyphase.


Assuntos
Corticosterona/metabolismo , Hipóxia/metabolismo , Hipóxia/fisiopatologia , Ritmo Infradiano/fisiologia , Animais , Masculino , Ratos , Ratos Sprague-Dawley , Ratos Wistar
18.
J Craniofac Surg ; 28(6): e513-e515, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28692503

RESUMO

PURPOSE/BACKGROUND: Cyclic esotropia is a rare condition that mostly occurs in children, characterized by patterns of straight and strabismic days with a regular cycle of 24 to 96 hours. In this report, 2 patients of cyclic esotropia in adults who showed a regular 48-hour cycle of mild deviation on 1 day followed by a more severe deviation on the second day are presented. METHODS: Clinical reports, clinical features, imaging findings, and surgical outcomes are presented. RESULTS: In patient 1, a 42-year-old male with high myopia was diagnosed with progressive esotropia for 2 years. A medial and lateral rectus (LR) recession/resection was performed 9 months before. On day 1 after this surgery, a relatively mild esotropia was present which developed into a severe esotropia on day 2. Being diagnosed as cyclic esotropia with myopic strabismus fixus, he underwent a 4 mm re-recession of the medial rectus combined with a half-Jensen procedure in his right eye. After the second surgery, the cyclic pattern was no longer present. In patient 2, a 39-year-old female with high myopia had concomitant esotropia for 20 years. At 6 months following bilateral intraocular lens implantation for her high myopia, she demonstrated a cyclic strabismus. On day 1, a 25 prism dioptres esotropia was present, which increased to a 45 prism diopters esotropia on day 2. A 4 mm recession of the medial rectus and 6 mm resection of the LR was performed in her left eye. After surgery, the cyclic pattern disappeared. CONCLUSIONS: Cyclic esotropia can occur in adults with myopic strabismus fixus subjected to horizontal strabismus surgery and with concomitant strabismus following intraocular lens implantation for high myopia. Their cyclic strabismus consisted of a mild squint on day 1 which increased in severity on day 2. The extent of surgery required for correction was based upon the "severe esotropia" experienced on day 2 and resulted in an excellent therapeutic outcome.


Assuntos
Esotropia/complicações , Implante de Lente Intraocular/efeitos adversos , Miopia/complicações , Adulto , Esotropia/diagnóstico , Esotropia/cirurgia , Feminino , Humanos , Ritmo Infradiano , Implante de Lente Intraocular/métodos , Masculino , Miopia/diagnóstico , Miopia/cirurgia , Músculos Oculomotores/cirurgia , Procedimentos Cirúrgicos Oftalmológicos/métodos , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/cirurgia , Doenças Raras , Reoperação , Estrabismo/complicações
19.
Chronobiol Int ; 34(7): 981-984, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28574290

RESUMO

In situ growth of Sphagnum riparium Ångstr. shoots were monitored during the 2015 and 2016 growing seasons in Karelia, Russia. It was established that shoot growth rates fluctuated with a period of around 30 days, that is, showed a circatrigintan rhythm. Such rhythms from mosses have not been previously reported. Correlation of growth rates with the percentage of the illuminated portion of the Moon was statistically significant (p<0.01) in both years. Shoot growth rates were reliably higher around the new Moon compared to the full Moon. This phenomenon may be due either to causality or to a pure coincidence of processes with similar rhythms.


Assuntos
Ritmo Infradiano , Raízes de Plantas/crescimento & desenvolvimento , Estações do Ano , Sphagnopsida/crescimento & desenvolvimento , Lua , Federação Russa , Fatores de Tempo
20.
Am J Clin Nutr ; 104(1): 49-57, 2016 07.
Artigo em Inglês | MEDLINE | ID: mdl-27225435

RESUMO

BACKGROUND: The intake of sodium, chloride, and potassium is considered important to healthy nutrition and cardiovascular disease risk. Estimating the intake of these electrolytes is difficult and usually predicated on urine collections, commonly for 24 h, which are considered the gold standard. We reported on data earlier for sodium but not for potassium or chloride. OBJECTIVE: We were able to test the value of 24-h urine collections in a unique, ultra-long-term balance study conducted during a simulated trip to Mars. DESIGN: Four healthy men were observed while ingesting 12 g salt/d, 9 g salt/d, and 6 g salt/d, while their potassium intake was maintained at 4 g/d for 105 d. Six healthy men were studied while ingesting 12 g salt/d, 9 g salt/d, and 6 g salt/d, with a re-exposure of 12 g/d, while their potassium intake was maintained at 4 g/d for 205 d. Food intake and other constituents were recorded every day for each subject. All urine output was collected daily. RESULTS: Long-term urine recovery rates for all 3 electrolytes were very high. Rather than the expected constant daily excretion related to daily intake, we observed remarkable daily variation in excretion, with a 7-d infradian rhythm at a relatively constant intake. We monitored 24-h aldosterone excretion in these studies and found that aldosterone appeared to be the regulator for all 3 electrolytes. We report Bland-Altman analyses on the value of urine collections to estimate intake. CONCLUSIONS: A single 24-h urine collection cannot predict sodium, potassium, or chloride intake; thus, multiple collections are necessary. This information is important when assessing electrolyte intake in individuals.


Assuntos
Dieta , Eletrólitos/urina , Ritmo Infradiano , Potássio/urina , Cloreto de Sódio na Dieta/urina , Sódio/urina , Equilíbrio Hidroeletrolítico , Adulto , Aldosterona/urina , Eletrólitos/administração & dosagem , Humanos , Estudos Longitudinais , Masculino , Potássio/administração & dosagem , Sódio/administração & dosagem , Cloreto de Sódio na Dieta/administração & dosagem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...