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1.
BMC Med Ethics ; 23(1): 50, 2022 05 06.
Artigo em Inglês | MEDLINE | ID: mdl-35524301

RESUMO

Research regarding the drivers of acceptance of clinical decision support systems (CDSS) by physicians is still rather limited. The literature that does exist, however, tends to focus on problems regarding the user-friendliness of CDSS. We have performed a thematic analysis of 24 interviews with physicians concerning specific clinical case vignettes, in order to explore their underlying opinions and attitudes regarding the introduction of CDSS in clinical practice, to allow a more in-depth analysis of factors underlying (non-)acceptance of CDSS. We identified three general themes from the results. First, 'the perceived role of the AI', including items referring to the tasks that may properly be assigned to the CDSS according to the respondents. Second, 'the perceived role of the physician', referring to the aspects of clinical practice that were seen as being fundamentally 'human' or non-automatable. Third, 'concerns regarding AI', including items referring to more general issues that were raised by the respondents regarding the introduction of CDSS in general and/or in clinical medicine in particular. Apart from the overall concerns expressed by the respondents regarding user-friendliness, we will explain how our results indicate that our respondents were primarily occupied by distinguishing between parts of their job that should be automated and aspects that should be kept in human hands. We refer to this distinction as 'the division of clinical labor.' This division is not based on knowledge regarding AI or medicine, but rather on which parts of a physician's job were seen by the respondents as being central to who they are as physicians and as human beings. Often the respondents' view that certain core parts of their job ought to be shielded from automation was closely linked to claims concerning the uniqueness of medicine as a domain. Finally, although almost all respondents claimed that they highly value their final responsibility, a closer investigation of this concept suggests that their view of 'final responsibility' was not that demanding after all.


Assuntos
Sistemas de Apoio a Decisões Clínicas , Médicos , Inteligência Artificial , Atitude , Humanos , Pesquisa Qualitativa , Cidade de Roma
2.
Eur Rev Med Pharmacol Sci ; 26(7): 2631-2638, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35442479

RESUMO

OBJECTIVE: Temporary COVID-19 hotels have been established in Italy to assist the homeless people that test positive for SARS-CoV-2 and require isolation. This observational study aimed to investigate the characteristics of the subjects who were isolated at the Casa tra Noi COVID-19 hotel in Rome between October 2020 and May 2021 and to estimate the duration of SARS-CoV-2 positivity according to their main socio-demographic, behavioural and clinical features. SUBJECTS AND METHODS: Socio-demographic data, clinical history, and anamnestic data of guests were collected by the clinicians reviewing the medical documentation and face-to-face interviewing. Nasopharyngeal swabs were performed every 7 days and the presence of SARS-CoV-2 was assessed by RT-PCR. Median duration of SARS-CoV-2 positivity according to socio-demographic, behavioral factors and clinical condition was calculated. RESULTS: The 196 guests (161 males, 82.1%) had a median age of 41 years (IQR: 30-53), and were mostly African (87, 44.4%). Only asymptomatic/paucisymptomatic infections were observed. Almost half of the individuals (84, 42.9%) were affected by at least one co-morbidity, the frequency of which was higher among women (57.1% vs. 39.8%, p=0.06). The date of the negative SARS-CoV-2 molecular test was known for 144 guests (73.5%). Among these, the median duration of positivity was 21 days (IQR: 14-26) and did not significantly vary with age, country of origin, smoking status, alcohol or drug abuse. Among the co-morbidities, only infectious diseases significantly modified the duration of positivity, which increased from 21 to 34 days (p=0.013). CONCLUSIONS: Hotel guests were frequently affected by physical/mental co-morbidities. Duration of SARS-CoV-2 positivity was significantly prolonged only in individuals affected by an infectious disease.


Assuntos
COVID-19 , Adulto , Infecções Assintomáticas , COVID-19/epidemiologia , Feminino , Humanos , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Cidade de Roma/epidemiologia , SARS-CoV-2
3.
J Acoust Soc Am ; 151(3): 1676, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35364959

RESUMO

The COVID-19 pandemic affected the acoustic environment worldwide, entailing relevant reductions of equivalent noise levels (LAeq) during this exceptional period. In the context of the LIFE+ DYNAMAP project, two wireless acoustic sensor networks were deployed in Milan and Rome. Taking advantage of the built-in identification of anomalous noise events (ANE) in the sensors, this work analyses the effects of the COVID-19 lockdown in both urban and suburban acoustic environments from January to June 2020, considering the distribution of ANEs and the intermittency ratio (IR) as an indicator of the impact of noise on population. The results show statistically significant increments of ANEs in Rome during the lockdown, mainly on weekends, and especially at night, despite the significant decrease in salient events. Differently, ANEs decrease during the lockdown in Milan, mostly at daytime, as a result of population confinement. Although the IR increases in several urban locations, most sensed locations show a relevant decrease in IR during the confinement, which represents a noteworthy reduction of the negative impact of noise in the population of both cities. During the post-lockdown period, all the scores start to return to those observed in the pre-lockdown, but still remaining higher than in 2019.


Assuntos
COVID-19 , Acústica , COVID-19/epidemiologia , COVID-19/prevenção & controle , Controle de Doenças Transmissíveis , Humanos , Pandemias , Cidade de Roma/epidemiologia
4.
Ig Sanita Pubbl ; 78(1): 7-22, 2022.
Artigo em Italiano | MEDLINE | ID: mdl-35370293

RESUMO

Chronic obstructive pulmonary disease (COPD) is a chronic disease that causes high morbidity and mortality. In the Lazio Region, the Clinical Pathway (PDTA) for COPD was codified in 2016. An analysis of the medical records of a retrospective open cohort of 77 patients followed at the Outpatient Clinic Torrenova (ASL Roma 2) from 2017 to 2021, for a total of 305 visits, was performed. The mean interval between visits per individual patient was 169±124 days, the overall length of follow-up 613±388 days. The mean age of patients enrolled in the PDTA was 67 years, 90% were smokers or former smokers, and 30% had major comorbidities. At the first visit, 13% of the patients had normal spirometry, 36% mild obstruction (GOLD 1), 13% GOLD 2, 15% GOLD 3 and none GOLD 4. Regarding ABCD classification, 29% of the patients were compatible with class A, 3% with class B, 29% class C and 10% class D. The analysis of the severity of the patients through a composite score showed a Gaussian distribution of patients at the first visits, a positive correlation with the number of follow-ups and a negative correlation with the interval of follow-up visits; the overall length of follow-up did not correlate with the severity of the disease. The active COPD PDTA in ASL Roma 2 seems to hit the target of taking care of the patient in the early stages of the disease. The effects of early intervention on disease outcomes should be highlighted by further studies.


Assuntos
Procedimentos Clínicos , Doença Pulmonar Obstrutiva Crônica , Idoso , Volume Expiratório Forçado , Humanos , Doença Pulmonar Obstrutiva Crônica/diagnóstico , Doença Pulmonar Obstrutiva Crônica/terapia , Estudos Retrospectivos , Cidade de Roma , Índice de Gravidade de Doença
5.
Artigo em Inglês | MEDLINE | ID: mdl-35457417

RESUMO

BACKGROUND: on the 9 March 2020, the Italian government declared a state of lockdown on the entire national territory aimed at reducing the spread of SARS-CoV-2, causing strong repercussions for people's lifestyles. The aim of the study was to analyze the impact of the lockdown on the nutritional status and lipid profile of employees of an Italian teaching hospital. METHODS: an observational retrospective cohort study was carried out at the Department of Occupational Medicine of the Umberto I General Hospital of Rome, including all employees who underwent two consecutive occupational medical examinations before and after the first lockdown (9 March 2020-18 May 2020). Employee medical records were used as a data source. RESULTS: 1014 employees were involved in the study (50.6% nurses, 31% physicians, 14.8% technical staff, 3.6% administrative staff). Post lockdown BMI, total cholesterol and LDL values increased statistically significantly compared to pre lockdown ones. Nurses showed a significant association with increased BMI (p < 0.001), while workers with heart disease were inversely associated with total cholesterol (p < 0.001) and LDL (p < 0.001). CONCLUSION: this study showed that lockdown had a significant impact on employees' lifestyles. Further studies are needed to understand changes in health-related behaviors, such as diet and physical activity, of specific categories of workers over time under lockdown conditions.


Assuntos
COVID-19 , COVID-19/epidemiologia , Colesterol , Controle de Doenças Transmissíveis , Hospitais de Ensino , Humanos , Lipídeos , Estado Nutricional , Quarentena , Estudos Retrospectivos , Cidade de Roma , SARS-CoV-2
6.
Stem Cell Res Ther ; 13(1): 163, 2022 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-35413874

RESUMO

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. Whether extracellular vesicles are effective in treating IPF and what is the optimal administrative route is not clear. Our previous studies have shown that immunity and matrix regulatory cells (IMRCs) derived from human embryonic stem cells can safely treat lung injury and fibrosis in mouse models, and its mechanism of action is related to the paracrine effect. In this study, we investigated the therapeutic effects of IMRC-derived extracellular vesicles (IMRC-EVs) on a bleomycin-induced pulmonary fibrosis mouse model and explored the optimal route of administration. METHODS: To study the biodistribution of IMRC-EVs after administration via different routes, NIR labeled-IMRC-EVs were delivered by intratracheal (IT) or intravenous (IV) route, and in vivo imaging was acquired at different time points. The therapeutic effects of IMRC-EVs delivered by different routes were analyzed by assessing histology, lung function, cytokines levels, and transcriptome profiling. RNA-seq of lung tissues was performed to investigate the mechanisms of EV treatment through IT or IV administrations. RESULTS: IMRC-EVs mainly reserved in the liver and spleen when administrated via IV route; and mainly retained in the lungs via the IT route. IMRC-EVs administrated via both routes demonstrated a therapeutic effect as attenuated pulmonary fibrosis, improved lung function, and histological parameters. Based on our RNA-seq results, different pathways may be affected by IMRC-EVs administrated via IT or IV routes. In addition, in vitro experiments showed that IMRC-EVs inhibited epithelial-to-mesenchymal transition induced by TGF-ß. CONCLUSION: IMRC-EVs administrated via IT or IV routes generate different biodistributions, but are both effective for the treatment of bleomycin-induced pulmonary fibrosis. The therapeutic mechanisms of IMRC-EVs administrated via different routes may be different.


Assuntos
Vesículas Extracelulares , Células-Tronco Embrionárias Humanas , Fibrose Pulmonar Idiopática , Células-Tronco Mesenquimais , Animais , Bleomicina , Modelos Animais de Doenças , Vesículas Extracelulares/metabolismo , Células-Tronco Embrionárias Humanas/metabolismo , Humanos , Fibrose Pulmonar Idiopática/metabolismo , Células-Tronco Mesenquimais/metabolismo , Camundongos , Cidade de Roma , Distribuição Tecidual
7.
Epidemiol Prev ; 46(1-2): 59-67, 2022.
Artigo em Italiano | MEDLINE | ID: mdl-35354268

RESUMO

OBJECTIVES: to estimate the impact of the COVID-19 epidemic on total and cause-specific mortality in people residing and dead in the Municipality of Rome (Italy) in 2020, and to describe the causes of death of subjects with SARS-CoV-2 infection confirmed by molecular test. DESIGN: descriptive analysis of total and cause-specific mortality in 2020 in Rome and comparison with a reference period (2015-2018 for total mortality and 2018 for cause-specific mortality); descriptive analysis of cause-specific mortality in the cohort of SARS-CoV-2 infected subjects. SETTING AND PARTICIPANTS: 27,471 deaths registered in the Lazio mortality-cause Registry, relating to people residing and died in the municipality of Rome in 2020, 2,374 of which died from COVID-19.MAIN OUCOME MEASURES: all-cause mortality by month, gender, age group and place of death, cause-specific mortality (ICD-10 codes). RESULTS: in the municipality of Rome in 2020, an excess of mortality from all causes equal to +10% was observed, with a greater increase in the months of October-December (+27%, +56%, and +26%, respectively) in people aged 50+, with the greatest contribution from the oldest age groups (80+) who died in the nursing homes or at home. Lower mortality was observed in the age groups 0-29 years (-30%) and 40-49 years (-13%). In 2020, COVID-19 represents the fourth cause of death in Rome after malignant tumours, diseases of the circulatory system, and respiratory diseases. Excess mortality was observed from stroke and pneumonia (both in men and women), from respiratory diseases (in men), from diabetes, mental disorders, dementia and Parkinson's disease (in women). On the contrary, mortality is lower for all cancers, for diseases of the blood and haematopoietic organs and for the causes of the circulatory system. The follow-up analysis of SARS-CoV-2 positive subjects residing in Rome shows that a share of deaths (about 20%) reports other causes of death such as cardiovascular diseases, malignant tumours, and diseases of the respiratory system on the certificate collected by the Italian National Statistics Institute. CONCLUSIONS: the 2020 mortality study highlighted excesses for acute and chronic pathologies, indicative of possible delays in the diagnosis or treatment of conditions indirectly caused by the pandemic, but also a share of misclassification of the cause of death that is recognized as COVID-19 death.


Assuntos
COVID-19 , Adolescente , Adulto , Causas de Morte , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Cidade de Roma/epidemiologia , SARS-CoV-2 , Adulto Jovem
8.
Front Immunol ; 13: 844931, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35251045

RESUMO

TNF receptor 2 (TNFR2) has become one of the best potential immune checkpoints that might be targeted, mainly because of its vital role in tumor microenvironments (TMEs). Overexpression of TNFR2 in some tumor cells and essential function in immunosuppressive cells, especially regulatory T cells (Tregs), makes blocking TNFR2 an excellent strategy in cancer treatment; however, there is evidence showing that activating TNFR2 can also inhibit tumor progression in vivo. In this review, we will discuss drugs that block and activate TNFR2 under clinical trials or preclinical developments up till now. Meanwhile, we summarize and explore the possible mechanisms related to them.


Assuntos
Neoplasias , Receptores Tipo II do Fator de Necrose Tumoral , Humanos , Neoplasias/terapia , Cidade de Roma , Linfócitos T Reguladores , Microambiente Tumoral
9.
Sci Rep ; 12(1): 3333, 2022 02 28.
Artigo em Inglês | MEDLINE | ID: mdl-35228624

RESUMO

Intraoperative parathyroid hormone dosage allows real-time monitoring of the decrease in PTH levels during parathyroidectomy and verify procedure's efficacy. Currently, none of the interpretative criteria used has absolute accuracy. The aim of this study is to evaluate diagnostic accuracy of the Rome criterion verifying diagnostic significance of the individual assays. A total of 205 patients with primary hyperparathyroidism from a single adenoma were retrospectively evaluated and monitored with baseline PTH, PTH at 10 min and PTH at 20 min after adenoma excision. The accuracy of the latter two assays compared with baseline was compared by ROC curves. In addition, was evaluated the influence on these data of localization diagnostics (ultrasounds and scintigraphy), definitive histology, and type of surgery performed. The ratio of 20-min sampling to baseline in the Rome criterion showed highest diagnostic significance. This finding was not influenced by the type of surgery performed, definitive histologic examination, or intraoperative localization of the adenoma. The Rome criterion has shown its high reliability in detecting persistence. The ratio of sampling at 20 min to baseline is by far the best performing. Further studies are needed to evaluate whether sampling at 10 min after adenoma excision can be considered not mandatory.


Assuntos
Adenoma , Hiperparatireoidismo Primário , Neoplasias das Paratireoides , Adenoma/diagnóstico , Adenoma/cirurgia , Di-Hidrotaquisterol , Humanos , Hiperparatireoidismo Primário/diagnóstico , Hiperparatireoidismo Primário/cirurgia , Hormônio Paratireóideo , Neoplasias das Paratireoides/diagnóstico , Neoplasias das Paratireoides/cirurgia , Paratireoidectomia , Reprodutibilidade dos Testes , Estudos Retrospectivos , Cidade de Roma
12.
BMC Pulm Med ; 22(1): 48, 2022 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-35101007

RESUMO

BACKGROUND: A systematic examination of low-dose CT (LDCT) scan, beside lung nodules, may disclose the presence of undiagnosed diseases, improving the efficacy and the cost/efficacy of these programs. The study was aimed at evaluating the association between LDCT scan findings and non-oncologic and oncologic diseases. METHODS: The LDCT scan of participants to the "Un Respiro per la vita"® lung cancer screening program were checked and abnormal findings, beside lung nodules, recorded. First admission to the acute care because of cardiovascular (CD), respiratory (RD) and oncological diseases (OD) in the following three years were retrieved. The association of LDCT scan abnormal findings with CD, RD and OD was assessed through univariable and multivariable logistic regression models. RESULTS: Mean age of 746 participants was 62 years (SD:5), 62% were male. 11 (1.5%) received a diagnosis of lung cancer. 16.1% participants were admitted to the acute care in the following three years: 8.6% for CD, 4.3% for RD and 5.2% for OD. Valve calcification (OR 2.02, p:0.02) and mucus plugs (OR 3.37, p:0.04) were positively associated with CD, while sub-pleural fibrosis had a protective role (OR 0.47, p:0.01). Lung nodules > 8 mm (OR 5.54, p: < 0.01), tracheal deviation (OR 6.04, p:0.01) and mucus plugs (OR 4.00, p:0.04) were positively associated with OD admissions. Centrilobular emphysema OR for RD admissions was 1.97 (p:0.06). CONCLUSIONS: The observed association between selected LDCT findings and ensuing CD, RD and OD suggests that the information potential of LCDT goes beyond the screening of lung cancer.


Assuntos
Detecção Precoce de Câncer/métodos , Detecção Precoce de Câncer/estatística & dados numéricos , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/epidemiologia , Tomografia Computadorizada por Raios X/estatística & dados numéricos , Idoso , Doença Crônica/epidemiologia , Feminino , Humanos , Neoplasias Pulmonares/etiologia , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Cidade de Roma/epidemiologia , Fumar/efeitos adversos
13.
J Pediatr Gastroenterol Nutr ; 74(3): 361-367, 2022 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-35226645

RESUMO

OBJECTIVES: The aim of this study was to assess the prevalence of functional gastrointestinal disorders (FGIDs) in children of Mediterranean area using Rome IV criteria and to compare the prevalence of FGIDs using Rome IV and Rome III criteria. METHODS: This was a cross-sectional study enrolling children and adolescents living in Croatia, Greece, Israel, Italy, Macedonia, and Serbia. Subjects were examined in relation to the presence of FGIDs, using the Rome IV criteria. Data were compared with the results of a previous study using Rome III data. RESULTS: We analyzed 1972 children ages 4 to 9 years (group A), and 2450 adolescents 10 to 18 years old (group B). The overall prevalence of FGIDs was 16% in group A and 26% in group B, with statistical differences among countries in both groups (P < 0.001). In group A, the prevalence of FGIDs and of functional constipation (FC) was significantly lower than in the previous study (P < 0.001), whereas in group B no significant difference was found. In both groups of age, the prevalence of abdominal migraine and irritable bowel syndrome decreased significantly (P < 0.001 and P < 0.001, respectively) using Rome IV versus Rome III criteria, conversely functional dyspepsia increased (P < 0.001). CONCLUSIONS: FGIDs are common in children and adolescents, their frequency increases with age, and there is a significant variation in the prevalence of some FGIDs among different European countries. The application of the Rome IV criteria resulted in a significantly lower prevalence of FGIDs in children compared with Rome III criteria.


Assuntos
Gastroenteropatias , Síndrome do Intestino Irritável , Adolescente , Criança , Pré-Escolar , Constipação Intestinal , Estudos Transversais , Gastroenteropatias/diagnóstico , Gastroenteropatias/epidemiologia , Humanos , Síndrome do Intestino Irritável/diagnóstico , Síndrome do Intestino Irritável/epidemiologia , Prevalência , Cidade de Roma , Inquéritos e Questionários
16.
Sci Total Environ ; 823: 153729, 2022 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-35143797

RESUMO

Magnetic biomonitoring methodologies were applied at Villa Farnesina, Rome, a masterpiece of the Italian Renaissance, with loggias frescoed by renowned artists such as Raffaello Sanzio. Plant leaves were sampled in September and December 2020 and lichen transplants were exposed from October 2020 to early January 2021 at increasing distances from the main trafficked road, Lungotevere Farnesina, introducing an outdoor vs. indoor mixed sampling design aimed at assessing the impact of vehicular particulate matter (PM) on the Villa Loggias. The magnetic properties of leaves and lichens - inferred from magnetic susceptibility values, hysteresis loops and first order reversal curves - showed that the bioaccumulation of magnetite-like particles, associated with trace metals such as Cu, Ba and Sb, decreased exponentially with the distance from the road, and was mainly linked to metallic emission from vehicle brake abrasion. For the frescoed Halls, ca. 30 m from the road, the exposure to traffic-related emissions was very limited or negligible. Tree and shrub leaves of the Lungotevere and of the Villa's Gardens intercepted much traffic-derived PM, thus being able to protect the indoor cultural heritage and providing an essential conservation service. It is concluded that the joint use of magnetic and chemical analyses can profitably be used for evaluating the impact of particulate pollution on cultural heritage within complex metropolitan contexts as a preventive conservation measure.


Assuntos
Poluentes Atmosféricos , Material Particulado , Poluentes Atmosféricos/análise , Monitoramento Biológico , Monitoramento Ambiental/métodos , Itália , Fenômenos Magnéticos , Material Particulado/análise , Cidade de Roma , Emissões de Veículos/análise
17.
Clin Ter ; 173(1): 64-66, 2022 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-35147649

RESUMO

ABSTRACT: COVID-19 has dramatically affected working forces. We aim to report our occupational medicine service's experience in managing suspected COVID-19 cases during the pandemic through a retrospec-tive observational study. We compared the number of days employees were absent from work due to flu-like symptoms from March 2020 to February 2021 to the same period the previous year (2019-2020). Two hundred thirty-four patients (+47.2% compared to the previous year) who tested negative for SARS-CoV-2 reported flu-like symp-toms; the number of days of absence from work was 2812 (+190.2% compared to the previous year). On average, employees with flu-like symptoms lost 12.07 working days compared to 6.12 in the previous year (p<0.0001). In conclusion, in our sample COVID-19 has increased the number of working day loss. However, our approach proved to be important, especially during the first months of the pandemic, to limit SARS-CoV-2 spread in workplaces.


Assuntos
COVID-19 , Pandemias , Humanos , Itália/epidemiologia , Cidade de Roma/epidemiologia , SARS-CoV-2
18.
Aliment Pharmacol Ther ; 55(10): 1311-1319, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35166374

RESUMO

BACKGROUND: Some drugs for irritable bowel syndrome (IBS) have serious side effects. AIMS: To examine the willingness of individuals with IBS to accept risks with medication in return for symptom cure. METHODS: We collected demographic, gastrointestinal symptoms, psychological health, quality of life and impact on work and daily activities data from 752 adults with Rome IV-defined IBS. We examined median willingness to accept death in return for cure with a hypothetical medication using a standard gamble, according to these variables. RESULTS: Participants would accept a median 2.0% (IQR 0.0%-9.0%) risk of death in return for a 98.0% (IQR 91.0%-100.0%) chance of permanent symptom cure. The median accepted risk of death was higher in men (5.0% vs 2.0%, P < 0.001), those with continuous abdominal pain (4.0% vs 1.0%, P < 0.001), more severe symptoms (P = 0.005 for trend), abnormal depression scores (P < 0.001 for trend), higher gastrointestinal symptom-specific anxiety (P < 0.001 for trend), and lower IBS-related quality of life (P < 0.001 for trend). Those willing to accept above median risk of death were more likely to be male (17.1% vs 9.1%, P < 0.001), take higher levels of risks in their daily life (P = 0.008 for trend), and report continuous abdominal pain (53.1% vs 39.4%, P < 0.001), and had higher depression (P = 0.004 for trend) and lower quality of life (P < 0.001 for trend) scores. CONCLUSION: Patients are willing to accept significant risks in return for cure of their IBS symptoms.


Assuntos
Síndrome do Intestino Irritável , Dor Abdominal/tratamento farmacológico , Adulto , Feminino , Humanos , Síndrome do Intestino Irritável/diagnóstico , Masculino , Qualidade de Vida , Cidade de Roma , Inquéritos e Questionários
19.
Oncogene ; 41(11): 1527-1535, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-35132182

RESUMO

Cells coordinate numerous biochemical reactions in space and time, depending on the subdivision of the intracellular space into functional compartments. Compelling evidence has demonstrated that phase separation induces the formation of membrane-less compartments to partition intracellular substances in a strictly regulated manner and participates in various biological processes. Based on the strong association of cancer with the dysregulation of intracellular physiological processes and the occurrence of phase separation in cancer-associated condensates, phase separation undoubtedly plays a significant role in tumorigenesis. In this review, we summarize the drivers and functions of phase separation, elaborate on the roles of phase separation in tumor pathogenesis and evolution, and propose substantial research and therapeutic prospects for phase separation in cancer.


Assuntos
Neoplasias , Humanos , Espaço Intracelular , Neoplasias/genética , Cidade de Roma
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