RESUMO
Objectives: The aim of this study was to characterize the main characteristics of this disease in relation to diagnosis, clinical aspects, progression and treatment as well as correlating them with remission time. Material and Methods: A systematic search was performed following the guidelines given by PRISMA and the Joanna Briggs Institute. PubMed, Web of Science and Scopus were the databases used. Results: The final analysis resulted in 108 articles with 173 clinical cases. The longest remission time for signs and symptoms (>7 weeks) was registered among male patients (p = 0.02) and outside the oral cavity; however no significant correlation was observed (p>0.05). A high risk of bias was the most common rating among the articles analyzed (55%); followed by moderate (27%) and low (18%). The lack of standardization in clinical case report descriptions made it difficult to gain a thorough knowledge of the essential characteristics of the NS patho-logical processes. Conclusion: It is recommended that publications follow the standards recommended by the literature; in addition, studies using advanced technologies to better understand NS's pathological path are recommended so as to propose effective treatments for this disease. (AU)
Assuntos
Humanos , Glândulas Salivares , Sialometaplasia Necrosante , Odontologia Baseada em Evidências , Patologia Bucal , DiagnósticoRESUMO
Necrotizing sialometaplasia (NS) affects salivary glands, and despite being a benign condition, its clinical and histopathological features sometimes mimic other malignant pathologies of epithelial origin. This article presents two cases of NS and discusses clinicopathological features and the differential diagnosis of this condition. The first case, a 76-year-old woman with a 6-month history of painful oral thrush. Intraoral examination showed an ulcerative lesion located on the hard palate. The clinical hypothesis was squamous cell carcinoma. Second, a 26-year-old man with a 40-days ulcerative lesion on the soft palate. Intraoral examination revealed a reddish ulcer measuring 0.5 cm. Clinical hypothesis was traumatic ulcer. In both cases, a biopsy was performed, and a histopathological diagnosis of NS was established. NS cause is poorly understood, and its clinical features resemble other oral lesions with ulcerative aspects. Thus, dentists must be aware of the clinical features of oral ulcers with more than a 2-week duration without defined etiology.
Assuntos
Úlceras Orais , Sialometaplasia Necrosante , Masculino , Feminino , Humanos , Idoso , Adulto , Sialometaplasia Necrosante/diagnóstico , Sialometaplasia Necrosante/patologia , Úlcera/diagnóstico , Úlcera/patologia , Glândulas Salivares/patologia , Palato Duro/patologia , Úlceras Orais/diagnóstico , Diagnóstico DiferencialRESUMO
Necrotizing sialometaplasia (NS) is a benign, self-limiting inflammatory entity that mainly affects the minor salivary glands located in the hard palate. Classically, NS is characterized as a nodule that evolves to a central ulcer. The most widely recognized triggering factor is an ischemic event. The diagnosis becomes a challenge in non-ulcerated NS cases which is essential to rule out the possibility of salivary gland tumors, especially the malignant ones. Here, we presented a case of a 32-year-old male patient with a 1-month complaint of a painful, slightly elevated erythematous area on the hard palate. Incisional biopsy was performed, and NS was diagnosed based on histopathological and immunohistochemical analyses. Clinicians should be aware of and consider NS as a differential diagnosis of minor salivary gland tumors, particularly when it presents as a non-ulcerated clinical aspect.
Assuntos
Humanos , Masculino , Adulto , Sialometaplasia Necrosante , Neoplasias das Glândulas Salivares/patologia , Palato Duro/patologia , Diagnóstico DiferencialRESUMO
RESUMEN: La sialometaplasia necrotizante (SN) es una rara enfermedad benigna, inflamatoria, autolimitante, que afecta más frecuentemente a las glándulas salivales menores y que comúnmente se asocia a las ubicadas en la porción más posterior del paladar duro. Su etiología no esta clara, la mayoría de los autores sugieren que una lesión química, física o biológica de los vasos sanguíneos produciría cambios isquémicos, que provocarían infarto del tejido glandular con necrosis, inflamación e intento de reparación. Clínicamente puede presentarse como una úlcera de márgenes irregulares, ligeramente elevados y lecho necrótico, mientras que histopatológicamente se caracteriza por presentar metaplasia escamosa de conductos y acinos e hiperplasia pseudoepiteliomatosa del epitelio mucoso. La similitud de sus características clínicas e histopatológicas con algunas lesiones glandulares malignas de la cavidad oral, puede resultar en tratamientos innecesarios, considerando que la SN se trata de una patología autoresolutiva, por lo que es fundamental realizar un correcto diagnóstico clínico e histopatológico para evitar tratamientos quirúrgicos mutilantes o innecesarios. En el presente trabajo se presenta un caso de una mujer joven, con diagnóstico de SN, con sus características clínicas, histopatológicas y la evolución de la lesión.
ABSTRACT: The Necrotizing Sialometaplazia (NS) it's a rare self-limiting, inflammatory, benign disease, that most frequently affects the minor salivary glands and it is commonly associated to the glands located at the most posterior portion of the hard palate. Its etiology is not clear. Most authors suggest that a chemical, physical or biological lesion of the blood vessels would produce ischemic changes, which lead to infarction of muscle tissue with necrosis, inflammation and attempts to repair. Clinically it can present as a slightly elevated ulcer with irregular edges and necrotic bed, while histopathologically it is characterized for present squamous metaplasia of ducts and acini and pseudoepitheliomatous hyperplasia of mucosal epithelium. The similarity of its clinical and histopathological characteristics with some malignant glandular lesions of the oral cavity, can result in unnecessary treatments, considering that NS is a self-sustaining pathology, it is therefore essential to perform a correct clinical and histopathological diagnosis to avoid mutilating or unnecessary surgical treatments. In the present work we present the case of a young woman, with diagnosis of NS, with its clinical and histopathological characteristics and the evolution of the lesion.
Assuntos
Humanos , Feminino , Adulto , Sialometaplasia Necrosante/diagnóstico , Carcinoma de Células Escamosas/diagnóstico , Glândulas Salivares/patologia , Biópsia , Tomografia Computadorizada de Emissão , Palato Duro , Diagnóstico DiferencialRESUMO
Introducción: La sialometaplasia necrotizante (SN) es una rara enfermedad benigna, inflamatoria de las glándulas salivales menores y mayores, comúnmente asociada a las ubicadas en la porción más posterior del paladar duro. La similitud de sus características clínicas e histológicas con algunas lesiones glandulares malignas, puede resultar en tratamientos innecesarios, considerando que la SN se resuelve espontáneamente entre 3-12 semanas. Caso clínico: Presentamos el caso de un adulto joven, con diagnóstico de SN, con sus características clínicas, histológicas y la evolución de la lesión.
Salivary glands Introduction: Necrotizing sialometaplasia (NS) is a rare benign inflammatory disease that affects the major and minor salivary glands. Commonly associated with the salivary glands of the rearmost portion of the hard palate. The similarity of their clinical and histological with some malignant glandular lesions may result in unnecessary treatment, whereas the NS resolves spontaneously within 3-12 weeks. Clinical case: We present the case of a young adult diagnosed with NS, with its clinical, histological and evolution of the injury.
Necrotizing sialometaplasia
Salivary glands
Assuntos
Humanos , Masculino , Adulto , Glândulas Salivares/patologia , Sialometaplasia Necrosante/patologia , Sialometaplasia Necrosante/cirurgiaRESUMO
Adenoid cystic carcinoma is a malignant tumor which occurs frequently in hard palate associated with minor salivary glands. The lesion generally presents as a painful slow growing mass and it is characterized by recurrences and distant metastasis resulting in a poor prognosis for the patient. This paper reports an atypical adenoid cystic carcinoma with palatal perforation which occurred in a young woman. Initial diagnostic hypothesis were necrotizing sialometaplasia and lues. Although adenoid cystic carcinoma is common in hard palate, cases with palatal perforation are uncommon and may lead to delay in diagnosis and therapy.
Assuntos
Carcinoma Adenoide Cístico/patologia , Palato Duro/patologia , Neoplasias das Glândulas Salivares/patologia , Glândulas Salivares Menores/patologia , Adulto , Carcinoma Adenoide Cístico/diagnóstico , Carcinoma Adenoide Cístico/diagnóstico por imagem , Diagnóstico Tardio , Feminino , Humanos , Cavidade Nasal/patologia , Invasividade Neoplásica , Prognóstico , Radiografia , Neoplasias das Glândulas Salivares/diagnóstico , Neoplasias das Glândulas Salivares/diagnóstico por imagem , Sialometaplasia Necrosante/diagnóstico , Sífilis/diagnósticoRESUMO
Necrotizing sialometaplasia (NS) is a self-limiting, benign, inflammatory disease of the minor salivary glands of the hard palate. The main significance of the NS lesion lies in the fact that it may be mistaken for mucoepidermoid or squamous cell carcinoma. A case report is presented of a patient with NS who was HIV positive; the lesion was located in the minor salivary glands of the hard palate. Clinically, the lesion presented as a deep ulcer with slightly elevated irregular borders and a necrotic base in the hard palate. Histologically, the tissue was characterized by squamous metaplasia of ducts and acini, lobular coagulation necrosis, and pseudoepitheliomatous hyperplasia of the overlying epithelium. The lesion disappeared completely after 2 weeks.
Assuntos
Soropositividade para HIV/complicações , Palato Duro/patologia , Glândulas Salivares Menores/patologia , Sialometaplasia Necrosante/diagnóstico , Carcinoma de Células Escamosas/diagnóstico , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/diagnóstico , Úlceras Orais/diagnósticoRESUMO
In this article we present 2 cases of necrotizing sialometaplasia (NS) associated with angiocentric lymphoma of the midline. Immunohistochemical analysis confirmed a T-cell origin, and in situ hybridization in one case revealed its relationship to Epstein-Barr virus. These findings suggest that vascular occlusion by the neoplastic cells produces ischemia, which leads to local infarction contributing to the salivary gland lesion. To our knowledge, the association between angiocentric lymphoma and NS has been previously reported in only one instance, and we suggest that this particular type of lymphoma should be added to the list of related conditions for NS.
Assuntos
Infecções por Vírus Epstein-Barr/complicações , Linfoma de Células T/complicações , Neoplasias Palatinas/complicações , Neoplasias dos Seios Paranasais/complicações , Sialometaplasia Necrosante/diagnóstico , Sialometaplasia Necrosante/etiologia , Adulto , Infecções por Vírus Epstein-Barr/diagnóstico , Feminino , Herpesvirus Humano 4/genética , Herpesvirus Humano 4/isolamento & purificação , Humanos , Hibridização In Situ , Linfoma de Células T/patologia , Linfoma de Células T/terapia , Linfoma de Células T/virologia , Masculino , Neoplasias Palatinas/patologia , Neoplasias Palatinas/terapia , Neoplasias Palatinas/virologia , Palato , Neoplasias dos Seios Paranasais/patologia , Neoplasias dos Seios Paranasais/terapia , Neoplasias dos Seios Paranasais/virologia , Glândulas Salivares/irrigação sanguínea , Glândulas Salivares/patologia , Sialometaplasia Necrosante/patologia , Sialometaplasia Necrosante/terapiaRESUMO
Cocaine abuse and the consequent prevalence of the damage associated with it have increased in the global population. The damage depends on the route of administration, where an important sequel of snorting is perforation of the nasal septum and palate. Necrosis of the palate, meanwhile, is also the manifestation of other diseases such as tertiary syphilis, necrotizing sialometaplasia and malignant neoplasms. The differential diagnosis of such lesions is important for determining appropriate treatment. A case of an ulcerated lesion in the palate of a cocaine-using patient whose diagnosis was necrotizing sialometaplasia is reported.
Assuntos
Transtornos Relacionados ao Uso de Cocaína/complicações , Palato Mole , Sialometaplasia Necrosante/induzido quimicamente , Adulto , Humanos , MasculinoRESUMO
Necrotizing sialometaplasia (NS) is a self-limiting inflammatory disease, that involves salivary glands, more frequently the minor ones. Although its etiopathogenesis remains still unknown some authors suggest that a physico-chemical or biological injury on the blood vessels may produce ischemic changes, leading to infarction of the gland and its further necrosis. Its clinical and histologic feature resemble malignancy. Clinically it may appear like an ulcer with slightly elevated irregular borders and necrotic base. Histologic features are squamous metaplasia of ducts and acini and a pseudoepitheliomatous hyperplasia of the overlying mucosa. These characteristics may induce to an inapropiated diagnosis of malignant neoplasia. A correct diagnosis to avoid mutilant surgical treatments is essential, considering that it is a self-limiting disease. In this report we describe five cases of NS in females, located in minor glands of the palate.
Assuntos
Sialometaplasia Necrosante , Adolescente , Adulto , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Sialometaplasia Necrosante/patologiaRESUMO
Con el propósito de describir las manifestaciones orales en pacientes con trastornos de la conducta alimentaria (TCA) se realizó un estudio prospectivo de observación de junio a septiembre de 1999, en el Servicio de Odontopediatría del Hospital Humberto Notti. Se examinaron 26 pacientes con trastornos alimentarios (25 mujeres, 1 varón). La frecuencia de TCA obtenida en nuestro estudio fue 35 por ciento anorexia, 46 por ciento bulimia y 19 por ciento mixto. El rango de edad osciló entre los 12 y 22 años (media 15 años). Se observó una alta incidencia de obturaciones desbordantes en pacientes bulímicas (p=0,02), como así también una alta incidencia de erosión dentaria en pacientes que provocaban el vómito (p=0,005). Motivó este trabajo la preocupación por una patología cuya incidencia ha aumentado en forma significativa en nuestro medio donde el odontólogo forma parte del equipo interdisciplinario de tratamiento y puede ser el primer profesional en detectar algún signo de sospecha en pacientes con posibles trastornos alimentarios (AU)
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Anorexia Nervosa/complicações , Bulimia/complicações , Mucosa Bucal/lesões , Interpretação Estatística de Dados , Distribuição por Idade , Distribuição por Sexo , Transtornos da Alimentação e da Ingestão de Alimentos/complicações , Transtornos da Alimentação e da Ingestão de Alimentos/epidemiologia , Interpretação Estatística de Dados , Estudos Prospectivos , Saliva Artificial/uso terapêutico , Abrasão Dentária/etiologia , Xerostomia/etiologia , Sialometaplasia Necrosante/etiologia , Reabilitação Bucal/métodosRESUMO
Con el propósito de describir las manifestaciones orales en pacientes con trastornos de la conducta alimentaria (TCA) se realizó un estudio prospectivo de observación de junio a septiembre de 1999, en el Servicio de Odontopediatría del Hospital Humberto Notti. Se examinaron 26 pacientes con trastornos alimentarios (25 mujeres, 1 varón). La frecuencia de TCA obtenida en nuestro estudio fue 35 por ciento anorexia, 46 por ciento bulimia y 19 por ciento mixto. El rango de edad osciló entre los 12 y 22 años (media 15 años). Se observó una alta incidencia de obturaciones desbordantes en pacientes bulímicas (p=0,02), como así también una alta incidencia de erosión dentaria en pacientes que provocaban el vómito (p=0,005). Motivó este trabajo la preocupación por una patología cuya incidencia ha aumentado en forma significativa en nuestro medio donde el odontólogo forma parte del equipo interdisciplinario de tratamiento y puede ser el primer profesional en detectar algún signo de sospecha en pacientes con posibles trastornos alimentarios
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Distribuição por Idade , Anorexia Nervosa/complicações , Bulimia/complicações , Transtornos da Alimentação e da Ingestão de Alimentos/complicações , Transtornos da Alimentação e da Ingestão de Alimentos/epidemiologia , Mucosa Bucal/lesões , Distribuição por Sexo , Interpretação Estatística de Dados , Abrasão Dentária/etiologia , Interpretação Estatística de Dados , Estudos Prospectivos , Reabilitação Bucal/métodos , Saliva Artificial/uso terapêutico , Sialometaplasia Necrosante/etiologia , Xerostomia/etiologiaRESUMO
Se comunican dos casos de sialometaplasia necrosante de las glándulas salivales palatinas, la cual es una condición inflamatoria que clínica e histológicamente puede simular una neoplasia maligna. Se describen los hallazgos clínicos y microscópicos sobresalientes y se insiste en la necesidad de diferenciar este padecimiento de otras lesiones eritematovioláceas y ulcerativas que afectan a la mucosa palatina.
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Glândulas Salivares/patologia , Sialometaplasia NecrosanteRESUMO
Se estudia la sialometaplasia necrotizante, enfermedad infrecuente que se corresponde con lesiones histicas inflamatorias en la cavidad bucal en una paciente femenina de 42 años, con factores de riesgo como el tabaquismo y el estres, elementos a considerar en la misma ya que se han observado estos asociados a dicha afeccion, que se caracteriza por la necrosis glandular de las glandulas salivales menores y la metaplasia ductal. (AU)
Assuntos
Sialometaplasia Necrosante/diagnósticoRESUMO
Se presenta un caso de Sialometaplasia Necrotizante de fosa nasal que correspondería al cuarto caso publicado en la literatura revisada. Realizamos una descripción clínica e histopatológica de la enfermedad enfatizando el problema del diagnóstico diferencial con carcinoma mucoepidermoide y escamoso, haciendo hincapié en la resolución espontánea de este cuadro. Revisamos la literatura publicada hasta la fecha encontrando 8 publicaciones. Si bien es cierto que se propone una teoría de oclusión vascular como etiología del cuadro, la paciente no tenía ningún antecedente de patología o tratamientos previos, lo cual no excluye posibles lesiones asintomáticas anteriores al proceso de sialometaplasia. Creemos necesario tener presente el diagnóstico de Sialometaplasia Necrotizante en el caso de lesiones tumorales en fosa nasal ya que, a pesar de ser infrecuente, cambia notoriamente el pronóstico de sobrevida y la magnitud de tratamiento al paciente