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1.
J Wound Care ; 30(Sup9a): XIIi-XIIiv, 2021 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-34597171

RESUMO

INTRODUCTION: Spider bites are common worldwide. Frequently symptoms resolve without any adverse outcome, but in rare cases the bite can cause severe morbidity. The most typical presentation of Mediterranean recluse spider (Loxosceles Rufescens) bite is a dermatonecrotic lesion of the skin (skin loxoscelism). When the only manifestation of a spider bite is an ulcerated skin lesion, clinical suspicion and differential diagnosis strongly depend on its site. We present the case of an ulcerated wound of the breast, diagnosed as a Mediterranean recluse spider bite. CASE PRESENTATION: A 79-year-old woman presented a 10cm-wide soft tissue ulceration of her left breast. At first, the diagnostic hypothesis of an ulcerated cancer was ruled out. Two family members revealed a recent history of Mediterranean recluse spider bite and the same clinical diagnosis was made for our patient. A wide excision was performed, with complete resolution of symptoms. DISCUSSION: No specific diagnostic criteria for spider bites are available. Diagnosis is usually clinical. Skin loxoscelism could be easily mistaken for cellulitis, various types of skin infections, cutaneous anthrax, vasculitis, scorpion sting, pyoderma gangrenosum, erythema migrans of Lyme disease or prurigo nodularis. A thorough anamnestic interview is fundamental to raise the diagnostic hypothesis. When possible, a biopsy is recommended and it is extremely important when the ulcer can mimic a cancer, as is the case in breast tissue. CONCLUSION: We recommend a wide excision of the wound after failure of conservative treatment, in order to obtain local control and to perform histological examination on a more representative specimen.


Assuntos
Pioderma Gangrenoso , Úlcera , Idoso , Mama , Diagnóstico Diferencial , Feminino , Humanos , Pele
2.
Acta Med Indones ; 53(3): 326-330, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34611073

RESUMO

SARS CoV-2 virus has infected more than 200 million people worldwide and more than 4.4 million in Indonesia. The vaccination program has become one of the solutions launched by many countries globally, including Indonesia, to reduce the transmission rate of COVID-19. Various vaccination platforms are produced, such as inactivated, viral vector, mRNA, and protein subunit. The vaccination booster program with mRNA platform (Moderna) was launched by the Indonesian government to give better protection for health care workers, particularly from delta variant. In this case report, we discuss one of the typical side effects of Moderna vaccine, which is referred to as the COVID arm.


Assuntos
Acetaminofen/administração & dosagem , Vacinas contra COVID-19 , COVID-19/prevenção & controle , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Hipersensibilidade Tardia , Pele/patologia , Analgésicos não Narcóticos/administração & dosagem , Biópsia/métodos , COVID-19/epidemiologia , Vacinas contra COVID-19/administração & dosagem , Vacinas contra COVID-19/efeitos adversos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/fisiopatologia , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/terapia , Feminino , Febre/tratamento farmacológico , Febre/etiologia , Humanos , Hipersensibilidade Tardia/induzido quimicamente , Hipersensibilidade Tardia/fisiopatologia , Hipersensibilidade Tardia/terapia , Reação no Local da Injeção/diagnóstico , Reação no Local da Injeção/etiologia , Reação no Local da Injeção/fisiopatologia , Pessoa de Meia-Idade , Médicos , SARS-CoV-2 , Resultado do Tratamento , Vacinação/métodos
3.
BMC Res Notes ; 14(1): 388, 2021 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-34627362

RESUMO

OBJECTIVE: Due to different concerns in using appropriate mosquito blood feeding techniques, this work focused on evaluating the effectiveness of two artificial mosquito feeding systems (Rutledge and Hemotek) and three different membranes (Parafilm, mouse and chicken skins). Female mosquitoes from an An. coluzzii strain aged between 2 and 5 days were exposed to blood with the two systems at time intervals (5, 10, 15, 20, 25 and 30 min) with blood used on the day of collection, the next day and 2 days after. RESULTS: Our results showed that the Hemotek system gave better blood feeding rates than the Rutledge system. Among the three membranes, the blood feeding rates with chicken and mouse skins were higher than those provided by the Parafilm membrane. Likewise, blood stored 1 day after collection gave higher levels than blood used on the day of collection and 2 days after. Regardless of the system, the lowest blood feeding rates were observed at 5 min compared to the other exposure times.


Assuntos
Culicidae , Animais , Galinhas , Comportamento Alimentar , Feminino , Camundongos , Pele
4.
Georgian Med News ; (318): 151-156, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34628398

RESUMO

The aim of the work was to determine the possibility of assessing the state of human health by the method of optical spectroscopy of skin and nail. To achieve this goal, Laser-Induced Fluorescence (LIF) spectroscopy was used. A special probe was designed, which makes it possible to record differential spectra and, as a result, to compare the shapes of spectral fluorescence lines. In vivo spectra of LIF intensities of the human finger pad and nail were measured. These spectra can be used to determine and characterize the state of human health, and it's also further monitoring in real time.When processing the spectra of different volunteers, it was found that the fluorescence spectra of the skin of physiologically healthy and pathological (in this case, type 1 and 2 diabetes) volunteers significantly differed from each other. Moreover, the analysis of these spectra makes it possible to assess the degree of pathology. It was also found that any of the three experimentally recorded fluorescence spectra is a superposition of the other two. A theoretical analysis of the multilayer model of human skin fluorescence has shown that this principle is always valid when the same chromophores are involved in fluorescence.


Assuntos
Diabetes Mellitus Tipo 1 , Diabetes Mellitus Tipo 2 , Humanos , Lasers , Pele , Espectrometria de Fluorescência
5.
Artigo em Chinês | MEDLINE | ID: mdl-34628822

RESUMO

SAPHO syndrome is a rare disease which affects the bones, joints, and skin. It is often misdiagnosed and treated mistakenly because of various clinical manifestations and general lack of awareness about the disease. The pathogenesis is inadequately understood, as a result, current therapy is empirical and aimed to control inflammatory process and alleviate pain. This paper summarizes the clinical manifestations and diagnosis and treatment scheme of SAPHO syndrome, and presents a case of patient with SAPHO syndrome who was treated in our department for bilateral tonsillectomy due to repeated pharyngalgia and fever for 10 years. Interestingly, the patient is getting better after the operation. The case is reported so as to provide reference for the diagnosis and treatment of SAPHO syndrome.


Assuntos
Síndrome de Hiperostose Adquirida , Tonsilite , Síndrome de Hiperostose Adquirida/diagnóstico , Doença Crônica , Humanos , Dor , Pele , Tonsilite/diagnóstico
6.
Nihon Shokakibyo Gakkai Zasshi ; 118(10): 975-980, 2021.
Artigo em Japonês | MEDLINE | ID: mdl-34629348

RESUMO

The patient is a female in her thirties. The patient was diagnosed with pustular psoriasis during the treatment course for pneumonia with the appearance of small pustules of the skin and with an increase of serum total bilirubin level. Pustular psoriasis is a designated intractable disease with extremely low prevalence in which the skin of the whole body is flushed with high fever and many sterile pustules occur. This disease has been reported to be accompanied by liver dysfunction. Liver dysfunction appeared 1-2 weeks after the eruption appears in most cases, but this is the rare case in which the liver disorder precedes.


Assuntos
Hepatopatias , Psoríase , Dermatopatias Vesiculobolhosas , Feminino , Humanos , Hepatopatias/complicações , Psoríase/complicações , Pele
7.
Front Cell Infect Microbiol ; 11: 712360, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34604106

RESUMO

The skin microbiota has been recognized to play an integral role in the physiology and pathology of the skin. The crosstalk between skin and the resident microbes has been extensively investigated using two-dimensional (2D) and three-dimensional (3D) cell cultures in vitro; however, skin colonization by multiple species and the effects of interspecific interactions on the structure and function of skin remains to be elucidated. This study reports the establishment of a mixed infection model, incorporating both commensal (Staphylococcus epidermidis) and pathogenic (Staphylococcus aureus) bacteria, based on a 3D human epidermal model. We observed that co-infecting the 3D epidermal model with S. aureus and S. epidermidis restricted the growth of S. aureus. In addition, S. aureus induced epidermal cytotoxicity, and the release of proinflammatory cytokines was attenuated by the S. aureus-S. epidermidis mixed infection model. S. epidermidis also inhibited the invasion of the deeper epidermis by S. aureus, eliciting protective effects on the integrity of the epidermal barrier. This 3D culture-based mixed infection model would be an effective replacement for existing animal models and 2D cell culture approaches for the evaluation of diverse biotic and abiotic factors involved in maintaining skin health.


Assuntos
Coinfecção , Staphylococcus aureus , Animais , Humanos , Pele , Fenômenos Fisiológicos da Pele , Staphylococcus , Staphylococcus epidermidis
8.
Front Cell Infect Microbiol ; 11: 720674, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34631601

RESUMO

Background: Atopic dermatitis (AD) is characterized by an altered skin microbiome dominantly colonized by S. aureus. Standard treatment includes emollients, anti-inflammatory medications and antiseptics. Objectives: To characterize changes in the skin microbiome during treatment for AD. Methods: The skin microbiomes of children with moderate-to-severe AD and healthy children were investigated in a longitudinal prospective study. Patients with AD were randomized to receive either standard treatment with emollients and topical corticosteroids or standard treatment with the addition of dilute bleach baths (DBB) and sampled at four visits over a three-month period. At each visit, severity of AD was measured, swabs were taken from four body sites and the composition of the microbiome at those sites was assessed using 16S rRNA amplification. Results: We included 14 healthy controls and 28 patients. We found high relative abundances of S. aureus in patients, which correlated with AD severity and reduced apparent alpha diversity. As disease severity improved with treatment, the abundance of S. aureus decreased, gradually becoming more similar to the microbiomes of healthy controls. After treatment, patients who received DBB had a significantly lower abundance of S. aureus than those who received only standard treatment. Conclusions: There are clear differences in the skin microbiome of healthy controls and AD patients that diminish with treatment. After three months, the addition of DBB to standard treatment had significantly decreased the S. aureus burden, supporting its use as a therapeutic option. Further study in double-blinded trials is needed.


Assuntos
Dermatite Atópica , Microbiota , Criança , Dermatite Atópica/terapia , Humanos , Estudos Prospectivos , RNA Ribossômico 16S/genética , Pele , Staphylococcus aureus
11.
J Wound Care ; 30(10): 868-873, 2021 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-34644142

RESUMO

OBJECTIVE: Due to the similarities of glabrous skin, the plantar region is an excellent donor area for covering complex palmar-plantar wounds. However, taking grafts from the plantar area often results in significant morbidity at the donor site or non-integration of the graft due to the greater thickness of the plantar corneal layer. METHOD: This is a prospective case series including patients with burns or wounds who have been treated with a dermal graft using the bilaminar 'trapdoor' technique. This procedure is used to remove a thin graft from the deep plantar dermis after the partial elevation of the first layer including the entire epidermis and superficial part of the dermis. RESULTS: At the donor area in the four patients in this case series, we observed healing at around 10 days, and absence of hypertrophic scar in all patients. There was complete re-epithelialisation between two and three weeks from the periphery to the centre of the deep dermal graft, and from the glandular epithelium transferred with the graft. During the follow-up, patients presented aesthetic and functional features of glabrous and amelanotic skin, with similar resistance to those of the adjacent areas of the wound in the palmar-plantar region. CONCLUSION: This technique has some advantages, such as less surgical time, minimal morbidity in the plantar donor area, easy integration of the grafts, and maintenance of the functional and aesthetic properties of glabrous skin both in the plantar donor area and in the palmar-plantar recipient region. DECLARATION OF INTEREST: The authors have no conflicts of interest to declare.


Assuntos
Queimaduras , Traumatismos da Mão , Queimaduras/cirurgia , Traumatismos da Mão/cirurgia , Humanos , Pele , Transplante de Pele , Cicatrização
12.
Acta Cir Bras ; 36(8): e360801, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34644769

RESUMO

PURPOSE: Dipotassium glycyrrhizinate (DPG) has anti-inflammatory properties, besides promoting the regeneration of skeletal muscle. However, it has not been reported on skin wound healing/regeneration. This research aimed to characterize the effects of DPG in the treatment of excisional wounds by second intention. METHODS: Male adults (n=10) and elderly (n=10) Wistar rats were used. Two circular wounds were excised on the dorsal skin. The excised normal skins were considered adult (GAN) and elderly (GIN) naïve. For seven days, 2% DPG was applied on the proximal excision: treated adult (GADPG) and elderly (GIDPG), whereas distal excisions were untreated adult (GANT) and elderly (GINT). Wound healing areas were daily measured and removed for morphological analyses after the 14th and the 21st postoperative day. Slides were stained with hematoxylin-eosin, Masson's trichrome, and picrosirius red. RESULTS: Histological analysis revealed intact (GAN/GIN) and regenerated(GANT/GINT/GADPG/GIDPG) skins. No differences of wounds' size were found among treated groups. Epidermis was thicker after 14 days and thinner after 21 days of DPG administration. Higher collagen I density was found in GIDPG (14th day) and GADPG (21st day). CONCLUSIONS: DPG induced woundhealing/skin regeneration, with collagen I, being more effective in the first 14 days after injury.


Assuntos
Ácido Glicirrízico , Cicatrização , Animais , Anti-Inflamatórios , Ácido Glicirrízico/farmacologia , Masculino , Ratos , Ratos Wistar , Pele
13.
Can Vet J ; 62(10): 1071-1076, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34602634

RESUMO

A 13-year-old neutered male miniature dachshund suffered ~30% total skin loss following an attack by another dog. After numerous failed attempts at wound management and closure, the wound was successfully healed by epithelialization using tilapia skin grafts. At each tilapia skin graft placement, the wound bed appeared pink, clean, and healthy with excellent progression of epithelialization at all edges. With use of the tilapia grafts, epithelialization occurred at a rate of 1.76 mm/day. As a result, the wound reached complete closure by epithelialization with no evidence of wound contracture in 102 days. Key clinical message: Tilapia skin grafts were successfully used for management of a large bite wound in a dog and may promote accelerated epithelialization in full thickness skin wounds.


Assuntos
Tilápia , Animais , Cães , Xenoenxertos , Masculino , Reepitelização , Pele , Transplante de Pele/veterinária
14.
MMW Fortschr Med ; 163(18): 12, 2021 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-34652643
15.
J Cosmet Laser Ther ; 23(1-2): 1-7, 2021 Feb 17.
Artigo em Inglês | MEDLINE | ID: mdl-34669525

RESUMO

Social distancing is conducive to grow the impact of artificial light in the daily life of the worldwide population with reported consequences to the skin. Sunlight is also essential for human development, indeed, solar radiation is composed of different types of wavelengths, which generate different skin effects. It can be divided into ultraviolet (UV), infrared (IR), and visible. UV radiation (UVA and UVB) has cutaneous biological effects ranging from photoaging, immunosuppression to melanoma formation, through the production of reactive oxygen species (ROS), inflammation and elevation of the energy state of organic molecules, changing the DNA structure. IR radiation reaches deeper layers of the skin and is also related to the generation of ROS, photoaging and erythema while visible light is responsible for generating ROS, pigmentation, cytokine formation, and matrix metallopeptidases (MMPs). Furthermore, artificial light could be harmful to the skin, as it can generate ROS, hyperpigmentation, and stimulate photoaging. Currently, we briefly summarized the cutaneous biological effects of sunlight, as well as artificial light on skin and remarked the opportunity of the evolution of current photoprotective formulas through new strategies with broad spectrum protection.


Assuntos
Pele , Protetores Solares , Humanos , Raios Infravermelhos , Luz Solar , Raios Ultravioleta/efeitos adversos
16.
Yonsei Med J ; 62(11): 969-980, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34672130

RESUMO

The skin is the first line of defense of our body, and it is composed of the epidermis and dermis with diverse immune cells. Various in vitro models have been investigated to recapitulate the immunological functions of the skin and to model inflammatory skin diseases. The simplest model is a two-dimensional (2D) co-culture system, which helps understand the direct and indirect cell-to-cell interactions between immune and structural cells; however, it has limitations when observing three-dimensional (3D) interactions or reproducing skin barriers. Conversely, 3D skin constructs can mimic the human skin characteristics in terms of epidermal and dermal structures, barrier functions, cell migration, and cell-to-cell interaction in the 3D space. Recently, as the importance of neuro-immune-cutaneous interactions in the inflammatory response is emerging, 3D skin constructs containing both immune cells and neurons are being developed. A microfluidic culture device called "skin-on-a-chip," which simulates the structures and functions of the human skin with perfusion, was also developed to mimic immune cell migration through the vascular system. This review summarizes the in vitro skin models with immune components, focusing on two highly prevalent chronic inflammatory skin diseases: atopic dermatitis and psoriasis. The development of these models will be valuable in studying the pathophysiology of skin diseases and evaluating the efficacy and toxicity of new drugs.


Assuntos
Dermatite Atópica , Dermatopatias , Técnicas de Cocultura , Humanos , Imunidade , Pele
17.
Dis Aquat Organ ; 146: 157-164, 2021 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-34672265

RESUMO

We examined 7 cutaneous mixed tumors in 2 wild-captured Japanese giant salamanders Andrias japonicus. The tumors were either already present and/or increased in size, or newly occurred during capativity. We sampled the 7 tumors from these animals and 3 verrucose protrusions from 3 unaffected animals, as controls, and examined them pathologically and virologically. The tumors (5 mm to 4 cm in size) were papillary protrusions or pendulated on the skin surface. The cut surface of the tumors was white, lobulated, partially hard, and contained mucus. All tumors presented similar histological characteristics of a hyaline structure and exhibited biphasic proliferation, with neoplastic epithelial cells partially composing the pseudo-ductal structure and staining positive for cytokeratin AE1/AE3. Vimentin 3B4-positive blast-like mesenchymal cells proliferated to fill the gaps in the epithelial components. Transition from unique mucous gland to neoplastic tissue was observed. The hyaline structure was stained blue by AZAN stain, Alcian blue-periodic acid-Schiff (PAS) double stain, and toluidine blue (TB) stain of pH 7.0, but was unstained by TB with pH values of 4.1 and 2.5. The mucus in the neoplastic tissue and in the mucous gland in verrucose protrusions was stained blue by Alcian blue-PAS double stain; TB staining at pH 7.0, 4.1, and 2.5 revealed metachromasy. No virus was detected in the tumors. The 7 tumors were diagnosed as cutaneous mixed tumors, and it was confirmed that the neoplastic cells originated from the mucous gland in the dermis. The biological behavior and pathological development of tumors should be elucidated because the tumors have the potential to negatively affect A. japonicus.


Assuntos
Neoplasias Cutâneas , Pele , Animais , Japão , Neoplasias Cutâneas/veterinária , Coloração e Rotulagem/veterinária , Urodelos
18.
Wiad Lek ; 74(8): 1885-1890, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34537737

RESUMO

OBJECTIVE: The aim: To prove safety of the new elixir and determine the effect on regenerative processes under conditions of the experimental trauma. PATIENTS AND METHODS: Materials and methods: The formula of the new dental elixir "Apiprol" includes biologically active components of bee products (propolis, comb capping wax), plant origin compounds. The elixir was single administered, intragastrally to white nonlinear mice weighing (22±2) g at doses at 50 mg/kg, 500 mg/kg, 5000 mg/kg. Acute toxicity of the new hygienic product "Apiprol" was investigated by a single application at the rate of 1000 and 5000 mg/kg animal weight. Subacute (chronic) toxicity was studied when elixir was applied to the skin of 10 mice at a single daily dose of 500 mg/kg for one month. A local irritant effect of the elixir on the oral mucosa was examined in 14 white rats daily after application for 3-5 min. The study of reparative activity was carried out on an experimental model of the wound process. RESULTS: Results: The elixir's components promote tissues regeneration, rapid epithelialization and wound surfaces healing, having a highly immune stimulating activity and antibacterial properties. CONCLUSION: Conclusions: The performed study proved a complete safety of the new elixir "Apiprol" and indicated a necessity of the further development of this preparation in order to create a greater variety of dental means produced in Ukraine.


Assuntos
Pele , Cicatrização , Animais , Camundongos , Ucrânia
19.
Nat Commun ; 12(1): 5256, 2021 09 06.
Artigo em Inglês | MEDLINE | ID: mdl-34489407

RESUMO

Tissue repair and healing remain among the most complicated processes that occur during postnatal life. Humans and other large organisms heal by forming fibrotic scar tissue with diminished function, while smaller organisms respond with scarless tissue regeneration and functional restoration. Well-established scaling principles reveal that organism size exponentially correlates with peak tissue forces during movement, and evolutionary responses have compensated by strengthening organ-level mechanical properties. How these adaptations may affect tissue injury has not been previously examined in large animals and humans. Here, we show that blocking mechanotransduction signaling through the focal adhesion kinase pathway in large animals significantly accelerates wound healing and enhances regeneration of skin with secondary structures such as hair follicles. In human cells, we demonstrate that mechanical forces shift fibroblasts toward pro-fibrotic phenotypes driven by ERK-YAP activation, leading to myofibroblast differentiation and excessive collagen production. Disruption of mechanical signaling specifically abrogates these responses and instead promotes regenerative fibroblast clusters characterized by AKT-EGR1.


Assuntos
Indóis/farmacologia , Mecanotransdução Celular/fisiologia , Pele/lesões , Sulfonamidas/farmacologia , Cicatrização/fisiologia , Animais , Diferenciação Celular , Células Cultivadas , Colágeno/metabolismo , Feminino , Fibroblastos , Quinase 1 de Adesão Focal/antagonistas & inibidores , Quinase 1 de Adesão Focal/metabolismo , Regeneração Tecidual Guiada , Humanos , Indóis/sangue , Mecanotransdução Celular/efeitos dos fármacos , Análise de Sequência de RNA , Análise de Célula Única , Pele/efeitos dos fármacos , Pele/patologia , Fenômenos Fisiológicos da Pele , Estresse Mecânico , Sulfonamidas/sangue , Suínos , Cicatrização/efeitos dos fármacos
20.
BMC Musculoskelet Disord ; 22(1): 769, 2021 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-34503484

RESUMO

BACKGROUND: Obesity is common in persons with a lower limb amputation, an amputation can also lead to further weight gain. Data regarding the prevalence of obesity in the Dutch population with a lower limb amputation are lacking. Furthermore, the impact of obesity on skin problems of the residual limb and the need of prosthetic repairs is unknown. The aim of this study was to determine the prevalence of obesity in Dutch persons with a lower limb amputation and to investigate the relationship between body weight, body mass index and skin problems of the residual limb and the frequency of prosthetic repairs. METHODS: A survey was performed among adults with a unilateral lower limb amputation due to any cause, and who are user of a prosthesis. The survey consisted of measurement of the subjects' body height and weight, a questionnaire which assessed self-reported skin problems in the previous month and factors potentially associated with these skin problems, and assessment of the frequency of visits to the orthopedic workshop. RESULTS: In total, 413 persons were enrolled. Of them, 39% (95 % confidence interval 35;44) were overweight and 28% (95% confidence interval 24;33) were obese. A total of 77% (95% confidence interval 73;81) reported one or more skin problems in the past month. Body weight and body mass index were neither associated with the presence of skin problems in general nor with the number of prosthetic repairs. Persons with severe skin problems had a slightly lower body mass index (26.6 kg/m2 vs. 28.0 kg/m2, p = 0.012). Persons with skin problems were younger than those without (difference in means 6.0 years (95% confidence interval 3.0;8.9)). CONCLUSIONS: Our findings show that obesity is common in the Dutch ambulant population with a lower limb amputation, with a prevalence being higher than in the general Dutch adult population. However, its negative impact on the presence of skin problems and the frequency of prosthetic repairs may be limited.


Assuntos
Amputação , Membros Artificiais , Índice de Massa Corporal , Pele/patologia , Adulto , Humanos , Extremidade Inferior/cirurgia , Países Baixos , Implantação de Prótese
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