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1.
Can Vet J ; 63(8): 841-844, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35919469

RESUMO

The surgical treatment of a gastroesophageal intussusception (GEI) in a 4-week-old male intact German shepherd puppy is described in this report. Bilateral gastropexies were performed; an incisional gastropexy on the right and a gastrostomy tube gastropexy on the left. The dog recovered well and is thriving long-term with no clinical signs of persistent megaesophagus. With the combination of early detection and surgical correction of GEI, mortality rates may be lower than the 95% mortality rate that has been reported in previous literature and supports new studies that have reported a 65% survival rate long-term. Key clinical message: Young animals presenting with vague clinical signs require thorough evaluation to identify uncommon, yet life-threatening diseases such as GEI. Early detection and interventions can subsequently lead to successful outcomes.


Intussusception gastro-oesophagienne chez un chiot berger allemand de 4 semaines. Le traitement chirurgical d'une intussusception gastro-oesophagienne (GEI) chez un chiot berger allemand mâle intact âgé de 4 semaines est décrit dans ce rapport. Des gastropexies bilatérales ont été réalisées; une gastropexie incisionnelle à droite et une gastropexie par tube de gastrostomie à gauche.Le chien a bien récupéré et se porte bien à long terme sans aucun signe clinique de mégaoesophage persistant.Avec la combinaison de la détection précoce et de la correction chirurgicale de la GEI, les taux de mortalité peuvent être inférieurs au taux de mortalité de 95 % qui a été rapporté dans la littérature antérieure et soutient de nouvelles études qui ont rapporté un taux de survie à long terme de 65 %.Message clinique clé :Les jeunes animaux présentant des signes cliniques vagues nécessitent une évaluation approfondie pour identifier des maladies rares, mais potentiellement mortelles, telles que la GEI. Une détection et des interventions précoces peuvent ensuite conduire à des résultats positifs.(Traduit par Dr Serge Messier).


Assuntos
Doenças do Cão , Doenças do Esôfago , Intussuscepção , Gastropatias , Animais , Doenças do Cão/diagnóstico , Doenças do Cão/cirurgia , Cães , Doenças do Esôfago/cirurgia , Doenças do Esôfago/veterinária , Intussuscepção/diagnóstico , Intussuscepção/cirurgia , Intussuscepção/veterinária , Masculino , Gastropatias/veterinária
2.
Nutrients ; 14(13)2022 Jun 27.
Artigo em Inglês | MEDLINE | ID: mdl-35807849

RESUMO

Evidence suggests that diets with high pro-inflammatory potential may play a substantial role in the origin of gastric inflammation. This study aimed to examine the association between the energy-adjusted dietary inflammatory index (E-DIITM) and gastric diseases at baseline and after a mean follow-up of 7.4 years in a Korean population. A total of 144,196 participants from the Korean Genome and Epidemiology Study_Health Examination (KoGES_HEXA) cohort were included. E-DII scores were computed using a validated semi-quantitative food frequency questionnaire. Multivariate logistic regression and Cox proportional hazards regression were used to assess the association between the E-DII and gastric disease risk. In the prospective analysis, the risk of developing gastric disease was significantly increased among individuals in the highest quartile of E-DII compared to those in the lowest quartile (HRquartile4vs1 = 1.22; 95% CI = 1.08-1.38). Prospective analysis also showed an increased risk in the incidence of gastritis (HRquartile4vs1 = 1.19; 95% CI = 1.04-1.37), gastric ulcers (HRquartile4vs1 = 1.47; 95% CI = 1.16-1.85), and gastric and duodenal ulcers (HRquartile4vs1 = 1.46; 95% CI = 1.17-1.81) in the highest E-DII quartile compared to the lowest quartile. In the cross-sectional analysis, the E-DII score was not associated with the risk of gastric disease. Our results suggest that a pro-inflammatory diet, indicated by high E-DII scores, is prospectively associated with an increased risk of gastric diseases. These results highlight the significance of an anti-inflammatory diet in lowering the risk of gastric disease risk in the general population.


Assuntos
Inflamação , Gastropatias , Estudos de Coortes , Estudos Transversais , Dieta/efeitos adversos , Humanos , Inflamação/diagnóstico , Inflamação/epidemiologia , República da Coreia/epidemiologia , Fatores de Risco
3.
Zhongguo Zhen Jiu ; 42(7): 821-4, 2022 Jul 12.
Artigo em Chinês | MEDLINE | ID: mdl-35793896

RESUMO

The ancient and modern discussions on the treatment of acupoints of the pericardium meridian of hand jueyin and non-acupoints along the meridian for stomach diseases were summarized, and the treatment principle of pericardium meridian for stomach diseases was explored. The relationship between pericardium meridian and stomach was discussed from the three perspectives of heart-stomach correlation, organ-meridian correlation and qi-position correlation. Based on these discussions, the guiding significance of the thoughts of selection effective treatment parts and the theoretical construction for clinical practice was considered and examined.


Assuntos
Terapia por Acupuntura , Meridianos , Gastropatias , Pontos de Acupuntura , Humanos , Pericárdio , Gastropatias/terapia
4.
Cesk Patol ; 58(2): 77-87, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35882542

RESUMO

Histological investigation of non-neoplastic endoscopic biopsies of gastric mucosa is one of the most common tasks most pathologists have to face on daily basis. Although the most common clinical question is still being whether Helicobacter organisms are found, pathologists have to bear in mind the whole spectrum of causes and associated morphological patterns of gastritides and gastropathies, governed by characteristic combinations of various types of inflammatory infiltrate, alterative and reactive changes of epithelial component, vascular response, and variability of stromal composition. The association of histopathologic pattern with supposed etiology can be sometimes proved by direct detection of the cause of morphologic changes in the investigated endoscopic sample.


Assuntos
Mucosa Gástrica , Gastrite , Gastropatias , Biópsia/efeitos adversos , Mucosa Gástrica/patologia , Gastrite/diagnóstico , Gastrite/etiologia , Gastrite/patologia , Infecções por Helicobacter/complicações , Infecções por Helicobacter/patologia , Helicobacter pylori , Humanos , Gastropatias/complicações , Gastropatias/diagnóstico , Gastropatias/patologia
5.
Am J Case Rep ; 23: e936631, 2022 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-35881563

RESUMO

BACKGROUND Gastric heterotopia is a benign entity found throughout the gastrointestinal tract but is rarely identified in the rectum. Since 1939, only 94 cases have ever been identified, and it can present as a mass formation with symptomatology that mimics colorectal malignancy. In some instances, malignancy has been shown to arise within rectal gastric heterotopia. Here, we present 3 cases from the past 20-year period of rectal gastric heterotopia at a single tertiary institution. CASE REPORT A 25-year-old man (case 1), a 58-year-old woman (case 2), and a 33-year-old man (case 3) were found to have polypoid mass-like lesions greater than 1.0 cm within the rectum. Following biopsy, pathology showed gastric oxyntic mucosa flanked by colorectal mucosa, thus indicating gastric heterotopia. Presenting symptoms from all patients consisted of unspecified anal pain, hematochezia, or a combination of both. All patients were treated with endoscopic mucosal resection (EMR), which provided relief of symptoms and confirmed no evidence of invasive malignancy. CONCLUSIONS Rectal gastric heterotopia can mimic malignancy and in very rare instances can harbor high-grade dysplasia as well as invasive carcinoma. EMR seems to be a definitive treatment that offers relief to patient symptomatology and reassurance that any dysplasia is identified and removed.


Assuntos
Coristoma , Doenças Retais , Gastropatias , Adulto , Coristoma/diagnóstico , Coristoma/patologia , Coristoma/cirurgia , Feminino , Mucosa Gástrica/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Doenças Retais/diagnóstico , Doenças Retais/patologia , Reto , Gastropatias/diagnóstico , Gastropatias/patologia , Gastropatias/cirurgia
6.
Intern Med ; 61(13): 1931-1938, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35781269

RESUMO

Objective This study aimed to determine the prevalence and endoscopic features of zinc acetate dihydrate tablet-associated gastric lesions. Methods We retrospectively examined the endoscopic features of 47 patients taking zinc acetate dihydrate tablets who underwent esophagogastroduodenoscopy. Results Gastric mucosal alterations, including redness, erosions, ulcers, and adhesion of the white coat, were observed in 29 of 47 patients (61.7%). Among patients with gastric lesions (group A), there was a significantly higher percentage of symptomatic patients in comparison to patients without lesions (group B) (65.5% vs. 22.2%; p<0.01). The background characteristics of the two groups did not differ to a statistically significant extent. On esophagogastroduodenoscopy, mucosal redness (n=27, 93.1%), erosions (n=26, 90.0%), adhesion of the white coat (n=25, 86.2%), and ulcers (n=9, 31.0%) were observed. None of the 19 patients who previously underwent esophagogastroduodenoscopy had gastric lesions before starting zinc acetate dihydrate. Esophagogastroduodenoscopy was performed after the cessation of zinc acetate dihydrate intake in six patients, and revealed the resolution of gastric lesions. Conclusion Gastric lesions were observed in 29 of 47 patients who were taking zinc acetate dihydrate tablets. The most common endoscopic findings were mucosal redness (93.1%), erosions (90.0%), adhesion of the white coat (86.2%), and ulcers (31.0%). Although the exact pathogenesis is uncertain, we believe that understanding the unique manifestations of this gastric lesion will help physicians manage adverse events in patients taking zinc acetate dihydrate tablets.


Assuntos
Gastropatias , Acetato de Zinco , Humanos , Estudos Retrospectivos , Gastropatias/induzido quimicamente , Comprimidos/efeitos adversos , Úlcera
7.
Sci Rep ; 12(1): 10737, 2022 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-35750699

RESUMO

Molecular diagnosis of helicobacters by PCR is simpler, more accurate, and feasible compared to other diagnostic methods. Validity and accuracy are highly dependent on the PCR primer design, diffusion time, and mutation rate of helicobacters. This study aimed to design 16srRNA -specific primers for Helicobacter spp. and H. pylori. Application of comparative statistical analysis of the diagnostic utility of the most available 16srRNA genus-specific primers. The new primers were designed using bioinformatics tools (MAFFT MSA and Gblocks command line). A comparative study was applied on nine genus-specific 16srRNA primers in comparison to the ConsH using in silico and laboratory evaluation. The results demonstrated that the best specificity and sensitivity of the primers designed for this study compared to other primers. The comparative study revealed that the heminested outer/inner primers were the worst. Although H276, 16srRNA(a), HeliS/Heli-nest, and Hcom had acceptable diagnostic utility, false positive and false negative results were obtained. Specificity testing on clinical samples indicated a surprising result; that H. pylori was not the sole enemy that we were looking for, but the Non-Helicobacter pylori Helicobacters should be considered as a real risk prognostic for gastric diseases, consequently, a specific diagnosis and treatment should be developed. This study concluded that our designed primers were the most specific and sensitive in comparison with other primers. In addition, in silico evaluation is not accurate enough for primer assessment and that the laboratory evaluation is mandatory.


Assuntos
Infecções por Helicobacter , Helicobacter pylori , Helicobacter , Gastropatias , Helicobacter/genética , Infecções por Helicobacter/diagnóstico , Helicobacter pylori/genética , Humanos , Reação em Cadeia da Polimerase/métodos , Sensibilidade e Especificidade
8.
BMC Vet Res ; 18(1): 253, 2022 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-35768837

RESUMO

BACKGROUND: Transmissible viral proventriculitis (TVP) causes significant economic loss to the poultry industry. However, the exact causative agents are obscure. Here we examine the virome of proventriculus from specified pathogen free (SPF) chickens that reproduced by infection of proventricular homogenate from broiler chicken with TVP using long read sequencing of the Pacific Biosciences RSII platform. The normal SPF chickens were used as control. RESULTS: Our investigation reveals a virome of proventriculitis, including three Gyrovirus genera of the Aneloviridae: Gyrovirus homsa1 (GyH1) (also known as Gyrovirus 3, GyV3) (n = 2662), chicken anemia virus (CAV) (n = 482) and Gyrovirus galga1 (GyG1) (also known as avian Gyrovirus 2, AGV2) (n = 11); a plethora of novel CRESS viral genomes (n = 26) and a novel genomovirus. The 27 novel viruses were divided into three clusters. Phylogenetic analysis showed that the GyH1 strain was more closely related to the strains from chicken (MG366592) than mammalian (human and cat), the GyG1 strain was closely related to the strains from cat in China (MK089245) and from chicken in Brazil (HM590588), and the CAV strain was more closely related to the strains from Germany (AJ297684) and United Kingdom (U66304) than that previously found in China. CONCLUSION: In this study, we revealed that Gyrovirus virome showed high abundance in chickens with TVP, suggesting their potential role in TVP, especially GyH1. This study is expected to contribute to the knowledge of the etiology of TVP.


Assuntos
Vírus da Anemia da Galinha , Gyrovirus , Doenças das Aves Domésticas , Gastropatias , Animais , Vírus da Anemia da Galinha/genética , Galinhas , Mamíferos , Filogenia , Proventrículo , Gastropatias/veterinária , Viroma
9.
Trials ; 23(1): 454, 2022 Jun 02.
Artigo em Inglês | MEDLINE | ID: mdl-35655286

RESUMO

BACKGROUND: Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders. Based on the various symptoms present in patients with functional dyspepsia postprandial distress syndrome (FD-PDS), routine agents such as acid suppressants, prokinetic drugs, and centrally acting drugs, offer limited treatment choices with potential side effects. As a preliminary clinical trial showed that the marketed product Zhizhu Kuanzhong Capsule (ZZKZ) can improve symptoms in FD-PDS patients, our study aims to provide further evidence on the clinical efficacy and safety of ZZKZ in the treatment of patients with FD-PDS. METHODS: In this multicenter, randomized, patient- and investigator-blinded, placebo-controlled, parallel-group clinical trial, we will recruit patients with FD-PDS from 18 hospitals in China and Australia. The trial will enroll patients with FD-PDS based on the Rome IV diagnostic criteria. A total of 480 eligible patients will be randomized 1:1 into either ZZKZ or placebo group with 8 weeks of treatment and 4 weeks of follow-up. The primary endpoint will be measured by a self-rated Visual Analogue Score (VAS) for the degree of discomfort with both symptoms of postprandial fullness and early satiation, recorded once a day and 7 days a week. The primary analysis will aim to compare the response rate for FD-PDS VAS score between the groups before and after 8 weeks of treatment with an alpha level of 0.05 (2-sided). DISCUSSION: This trial aims to strengthen the evidence for the efficacy and safety of ZZKZ, a marketed product, in treating FD-PDS. Compared to the previous clinical trial that targeted FD-PDS, this trial will have an 8-week double-blind treatment period to investigate the effect of long-term mediation through comparison with the placebo group. TRIAL REGISTRATION: ClinicalTrials.gov NCT03825692 . Registered on 28 January 2019.


Assuntos
Dispepsia , Gastroenteropatias , Gastropatias , Método Duplo-Cego , Dispepsia/diagnóstico , Dispepsia/tratamento farmacológico , Humanos , Estudos Multicêntricos como Assunto , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
10.
J Immunol Res ; 2022: 6969960, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35692506

RESUMO

Objective: This systematic review and meta-analysis was conducted to assess the efficacy of acupuncture treatment for postprandial distress syndrome (PDS). Methods: Search the Web of Science, the Cochrane Library, PubMed, and Embase databases with acupuncture randomized controlled trials for the treatment of patients with PDS. Strictly according to inclusion and exclusion quality assessment standards, the qualified ones are used to study the optimum extraction and data by two independent reviewers. Stata 15.0 software was used for meta-analysis. Result: We initially identified 63 studies, of which five (1253 participants) were eventually included in our analysis. There were 643 cases in the experimental group and 610 cases in the control group. Acupuncture had a significant effect on the total therapeutic effect (OTE) at week 4 (OR 4.74, 95% CI 02.88-7.83, Z = 6.10, P = 0 < 0.05). Significantly improved NDI (Nepean dyspepsia index) scores of PDS patients at week 4 (SMD 0.61, 95% CI 0.48 to 0.74). Significantly improved NDI scores in PDS patients at week 16 (SMD 0.49, 95% CI 0.27 to 0.71). After acupuncture treatment, the SID (dyspepsia symptom index) score of PDS patients decreased significantly at week 4 (SMD-0.52, 95% CI -0.73 to -0.32) and week 16 (SMD-0.59, 95% CI -0.81 to -0.36). Postprandial satiety scores (SMD-0.63, 95% CI -0.76 to -0.50) and early satiety scores (SMD-0.51, 95% CI -0.64 to -0.37) were also significantly lower at week 4 after acupuncture. Conclusion: This study highlighted that the acupuncture could significantly improve the overall therapeutic effect of PDS patients, alleviate the symptoms of postprandial fullness and early satiety, and improve the quality of life of patients. Our results supported that acupuncture was an effective therapeutic strategy for postprandial distress syndrome.


Assuntos
Terapia por Acupuntura , Dispepsia , Gastropatias , Terapia por Acupuntura/métodos , Dispepsia/diagnóstico , Dispepsia/terapia , Humanos , Período Pós-Prandial , Qualidade de Vida
11.
Medicine (Baltimore) ; 101(22): e29195, 2022 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-35665726

RESUMO

RATIONALE: Microwave ablation (MWA) has been proven to be an efficient and safe method for local tumor control of liver tumors. Reported complications are rare, but include liver abscess, hematoma, pleural effusion, and occasional thermal injury of the adjacent colon. Intestinal perforation usually requires immediate surgical treatment to prevent generalized peritonitis and sepsis. PATIENT CONCERNS AND DIAGNOSIS: Herein, we describe a case of gastric perforation following percutaneous MWA for hepatocellular carcinoma as a bridging therapy prior to liver transplantation. INTERVENTIONS: Due to the clinical condition of the patient, conservative treatment was considered sufficient. Nine months after MWA, successful liver transplantation followed. Intraoperative findings revealed a scar in the gastric wall with tight adhesions to the liver, requiring adhesiolysis and subsequent suturing. Postoperative recovery was uneventful. OUTCOME: At present, the patient is doing well. No further gastrointestinal events occurred. LESSON: To our knowledge, this is the first report of such a complication occurring after MWA. Moreover, in this case, the gastric perforation could be treated conservatively.


Assuntos
Carcinoma Hepatocelular , Ablação por Cateter , Neoplasias Hepáticas , Gastropatias , Carcinoma Hepatocelular/patologia , Carcinoma Hepatocelular/cirurgia , Ablação por Cateter/métodos , Tratamento Conservador , Humanos , Neoplasias Hepáticas/patologia , Neoplasias Hepáticas/cirurgia , Micro-Ondas/efeitos adversos , Gastropatias/cirurgia , Resultado do Tratamento
12.
Nutrients ; 14(10)2022 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-35631223

RESUMO

The present research purposed to examine the gastro-protective effect of Glycine max (L.) Merr. fermented using Lactobacillus delbrueckii ssp. delbrueckii Rosell-187 (Gastro-AD®) on ethanol/HCl-induced gastric damage, specifically on gastric acid secretion. After oral supplementation of Gastro-AD® to Sprague-Dawley (SD) rats with ethanol/HCl-induced gastric damage, we determined that Gastro-AD® attenuated the gastric mucosal lesion, hemorrhage and gastric acid secretion induced by ethanol/HCl. In addition, we observed that the Gastro-AD® treatment increased the serum prostaglandin E2 level and decreased the levels of gastric acid secretion-related receptors in both gastric tissues and primary gastric parietal cells. Furthermore, it decreased the levels of inflammatory factors, including serum histamine and expression of p-IκB, p-p65, iNOS and COX-2 and the activity of apoptotic signaling pathways, including those involving p-JNK, Bcl2/Bax, Fas, FADD, caspase-8 and caspase-3, in the stomach of the ethanol/HCl-treated rats. Thus, we suggest that Gastro-AD® supplementation may reduce ethanol/HCl-induced gastric acid secretion and prevent gastric injury.


Assuntos
Alimentos Fermentados , Gastropatias , Animais , Etanol/metabolismo , Etanol/toxicidade , Mucosa Gástrica , Ratos , Ratos Sprague-Dawley , Soja
13.
Comput Math Methods Med ; 2022: 1607099, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35495895

RESUMO

The study focused on the diagnostic value of deep learning-based ultrasound combined with gastroscope examination for upper gastrointestinal submucous lesions and nursing. A total of 104 patients with upper gastrointestinal submucous lesions diagnosed in hospital were selected as the research subjects. In this study, the feed forward denoising convulsive neural network (DnCNN) was improved, and the n-DnCNN model was designed and applied to ultrasonic image processing. The peak signal-to-noise ratio (PSNR) and structural similarity (SSIM) of Gaussian filtering, NL-means, and DnCNN were then compared with n-DnCNN. Subsequently, the distribution and types of submucosal lesions in different parts of the upper digestive tract were analyzed by ultrasound combined with gastroscope and gastroscope examination alone, and the diagnostic performance of this method was evaluated. The results showed that the average PSNR and SSIM of the n-DnCNN model were 33.01 dB and 0.87, respectively, which were significantly higher than GF, NL-means, and DnCNN algorithms, and the difference was statistically significant (P < 0.05). Of the 116 lesions detected, 49 were located in the esophagus (42.24%), 52 in the stomach (44.83%), and 15 in the duodenum (12.93%). Of the 49 esophageal submucosal lesions, 6.12% were located in the upper esophagus, 55.1% in the middle esophagus, and 38.79% in the lower esophagus, and the difference was statistically significant (P < 0.05). Of the gastric submucosal lesions, the lesions in the gastric cardia were significantly less than in other parts, and the difference was statistically significant (P < 0.05). The accuracy of ultrasound combined with gastroscope in the diagnosis of upper gastrointestinal submucous episodes was 82.32%, higher than that of gastroscope examination, and the difference was statistically significant (P < 0.05). In conclusion, the n-DnCNN model has a good noise reduction effect, and the obtained image is of high quality. Ultrasound combined with gastroscope examination can effectively improve the accuracy of diagnosis of upper gastrointestinal submucous lesions.


Assuntos
Aprendizado Profundo , Gastropatias , Gastroscópios , Humanos , Redes Neurais de Computação , Razão Sinal-Ruído , Ultrassonografia
14.
J Equine Vet Sci ; 116: 104002, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35490972

RESUMO

The role of the equine gastrointestinal microbiota in the pathogenesis of equine glandular gastric disease (EGGD) is poorly understood. To investigate whether the glandular gastric microbiota is altered in horses with EGGD. Prospective longitudinal study. Five Thoroughbred racehorses from one training center underwent gastroscopy as part of poor performance investigation. Samples were taken from EGGD lesions and adjacent normal mucosa using sheathed transendoscopic cytology brushes and frozen at -80°C. DNA was extracted for 16S rRNA sequencing, and sequences compared against a database to generate taxonomic classification of the microbiota. The same horses were sampled 6 months later. Normal glandular mucosal samples were characterized by a higher proportion of Proteobacteria (46.3%) than EGGD lesions (18.9%). Relative abundance of Firmicutes was lower in samples from normal mucosa (20.0%) than EGGD lesions (41.2%). Linear discriminant analysis effect size (LEfSe) confirmed a greater proportion of Firmicutes species was characteristic of samples collected from EGGD lesions due to a very high relative abundance of Sarcina (up to 92.4%) in two horses with EGGD. We were unable to comment on the stability of the glandular gastric microbiota over time. Small sample population. None of the horses examined had grossly normal gastric mucosa. The gastric microbiota appears altered in EGGD, although we are unable to demonstrate a causative effect. Sarcina was particularly increased in abundance in EGGD and may be a useful biomarker of disease. Sheathed cytology brushes were an effective method for sampling the gastric mucosa.


Assuntos
Doenças dos Cavalos , Microbiota , Gastropatias , Animais , Doenças dos Cavalos/epidemiologia , Cavalos , Estudos Longitudinais , Microbiota/genética , Estudos Prospectivos , RNA Ribossômico 16S/genética , Gastropatias/etiologia , Gastropatias/veterinária
15.
J Tradit Chin Med ; 42(3): 458-462, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35610017

RESUMO

OBJECTIVE: To clarify the relationship between helicobacter pylori (Hp) infection, tongue manifestation and gastroscopic manifestation, and explore the mechanism of action of "oral-gastric microecology" in the occurrence and development of stomach-related diseases. MEDHODS: A total of 1100 patients were divided into Hp positive group and Hp negative group according to 13C breath test results. The tongue manifestation materials from patients were collected to make tongue printing slides for morphological observation of exfoliative cells from tongue coating, and electronic gastroscopy was performed on the patients and the data was analyzed. RESULTS: Hp infection rate was about 45.95%; and the greasy coating was mostly observed in Hp positive group (63.14%, 0.05). The total tongue coating distribution was as follows: yellow greasy coating (56.66%, 0.05) > yellow coating > white coating > white greasy coating. The gastric mucosal roughness and mucosal hematoplastic plaques in the two groups were more common in the Hp positive group ( 0.05). There was a significant difference in the granular subgroup and in the rough mucosal group (< 0.05). CONCLUSIONS: Hp infection is more commonly observed in yellow greasy coating, and this can be used as a reference for Traditional Chinese Medicine in determining whether it is Hp infection or not. Mucosal granule roughness, hyperemia, and oral Hp showed association with Hp infection in the stomach and interacted with micro-ecological environment that is composed of the oral cavity.


Assuntos
Infecções por Helicobacter , Helicobacter pylori , Gastropatias , Mucosa Gástrica , Gastroscopia , Humanos , Língua
16.
J Clin Exp Hematop ; 62(2): 114-118, 2022 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-35474034

RESUMO

Lymphomatoid gastropathy (LyGa)/natural killer (NK)-cell enteropathy (NKCE) is recognized as a benign NK-cell lymphoproliferative disease. Due to its histological similarity to NK/T cell lymphoma, it is easy to misdiagnose, leading to unnecessary chemotherapy and poor quality of life. This disease is typically observed in the small and large intestines in North America, whereas almost all cases in Japan occur locally in the stomach. Only 11 LyGa/NKCE cases involving both gastric and intestinal lesions have been reported, and there are few reports providing endoscopic images throughout the gastrointestinal tract. We report a case of LyGa/NKCE involving both the stomach and small and large intestines with detailed upper gastrointestinal endoscopy, colonoscopy, capsule endoscopy and pathology images. Its pathogenesis currently remains elusive, but most patients with LyGa/NKCE in Japan have Helicobacter pylori (H. pylori) infection. Our patient was also positive for H. pylori infection at disease onset, but after receiving eradication therapy, ulcerative lesions in both stomach and intestine regressed and no recurrence was observed. This case suggests a link between the pathogenesis of LyGa/NKCE and H. pylori infection.


Assuntos
Infecções por Helicobacter , Linfoma , Transtornos Linfoproliferativos , Gastropatias , Neoplasias Gástricas , Infecções por Helicobacter/complicações , Humanos , Intestinos/patologia , Transtornos Linfoproliferativos/patologia , Qualidade de Vida , Gastropatias/etiologia , Gastropatias/patologia , Neoplasias Gástricas/patologia
17.
Vet Med Sci ; 8(4): 1472-1477, 2022 07.
Artigo em Inglês | MEDLINE | ID: mdl-35412651

RESUMO

INTRODUCTION: Equine glandular gastric disease (EGGD) is a common condition causing signs of gastric pain although lesions are highly variable in their appearance. The only definitive method to diagnose EGGD ante-mortem is gastroscopy. The current recommended method for describing these lesions is the European College of Equine Internal Medicine (ECEIM) guidelines; however, repeatability between users is variable. This study aimed to validate the reliability of lesion descriptions using ECEIM consensus guidelines, using four blinded equine internal medicine diplomates. METHODS: Ninety-two horses with EGGD with pre- and post-treatment gastroscopy images were identified using the electronic record at a UK equine hospital between 2012 and 2019. Eight horses were excluded due to non-diagnostic images. Four blinded observers used the recommended grading system to describe images and outcomes. Intraclass correlation coefficients and Krippendorff's alpha were used to determine reliability and agreement, respectively. RESULTS: Intraclass correlation coefficient for severity was 0.782 (95% confidence interval [CI] 0.722-0.832), for distribution was 0.671 (95% CI 0.540-0.763), for the descriptor raised was 0.635 (95% CI 0.479-0.741), fibrinosuppurative was 0.745 (95% CI 0.651-0.812), haemorrhagic was 0.648 (95% CI 0.513-0.744), hyperaemic was 0.389 (95% CI 0.232-0.522) and for outcome was 0.677 (95% CI 0.559-0.770). Krippendorff's alpha for severity was 0.466 (95% CI 0.466-0.418), for distribution was 0.304 (95% CI 0.234-0.374), for the descriptor raised was 0.268 (95% CI 0.207-0.329), fibrinosuppurative was 0.406 (95% CI 0.347-0.463), haemorrhagic was 0.287 (95% CI 0.229-0.344), hyperaemic was 0.112 (95% CI 0.034-0.188) and for outcome was 0.315 (95% CI 0.218-0.408). There was moderate reliability determined between observers using intra-class correlation coefficients and unacceptable agreement determined between observers using Krippendorff's alpha. DISCUSSION: These results suggest that the current grading system is not comparable between observers, indicating the need to review the grading system or define more robust criteria.


Assuntos
Doenças dos Cavalos , Gastropatias , Animais , Gastroscopia/veterinária , Doenças dos Cavalos/patologia , Cavalos , Humanos , Reprodutibilidade dos Testes , Gastropatias/diagnóstico , Gastropatias/veterinária
19.
J Dairy Sci ; 105(6): 5349-5369, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35469642

RESUMO

The objectives were as follows: (1) establish cow-level thresholds for prepartum nonesterified fatty acids (NEFA) and postpartum NEFA, ß-hydroxybutyrate (BHB), and haptoglobin (Hp) concentrations associated with negative health events; (2) evaluate cow-level associations between biomarkers and 305-d mature equivalent milk at the fourth test day (ME305) and reproductive performance; and (3) identify herd-alarm levels (proportion of cows sampled above the critical threshold) for biomarkers that are associated with herd-level changes in disorder incidence (displaced abomasum and clinical ketosis), reproductive performance, and ME305. In a prospective cohort study, 1,473 cows from 72 farms were enrolled from the northeastern United States. Blood samples were collected from the same 11 to 24 cows per herd during the late-prepartum and early-postpartum periods. Whole blood was analyzed for postpartum BHB concentrations; plasma was analyzed for prepartum and postpartum NEFA and postpartum Hp concentrations. Critical thresholds for the biomarkers associated with health events for all cows were established using a receiver operating characteristic curve analysis. Poisson, linear mixed effects, and Cox proportional hazards models investigated the association of the biomarkers with health and performance. The prepartum NEFA and Hp threshold associated with culling was ≥0.17 mmol/L and 0.45 g/L, respectively. The postpartum NEFA and BHB thresholds associated with diagnosis of metritis, displaced abomasum, or clinical ketosis were ≥0.46 mmol/L and ≥0.9 mmol/L, respectively. Multiparous cows with prepartum NEFA concentration ≥0.17 mmol/L produced 479 kg less ME305. Multiparous and primiparous cows with postpartum NEFA concentration ≥0.46 mmol/L produced 280 kg less and 446 kg more ME305, respectively. Cows with BHB concentration ≥0.9 and ≥1.1 mmol/L produced 552 kg more ME305 and had a 20% decreased risk of pregnancy within 150 d in milk, respectively; however, multiparous cows with BHB concentration ≥1.5 mmol/L produced 376 kg less ME305. Cows with Hp concentration ≥0.45 g/L produced 492 kg less ME305 and had 28% decreased risk of pregnancy within 150 DIM. Cows with Hp concentration ≥0.45 g/L had 19% decreased pregnancy risk to first service (PRFS). Herds above the herd-alarm levels for prepartum NEFA had a 6.0-percentage unit increase in disorder incidence and a 6.0-percentage unit decrease in 21-d pregnancy rate (PR) for multiparous cows, a 3.9-percentage unit increase in PR and a 5.8-percentage unit increase in the probability of pregnancy for primiparous cows. Herds above the herd-alarm levels for postpartum NEFA had a 5.8- and 4.2-percentage unit increase in disorder incidence for multiparous and primiparous cows, respectively, a 789 kg decrease in ME305 for multiparous cows, and a 6.8- and 6.3-percentage unit decrease and increase in PR and PRFS for multiparous cows, respectively. Herds above the herd-alarm levels for BHB had an 8.5-percentage unit increase in disorder incidence, a 332 and 229 kg increase in ME305 for primiparous and multiparous cows, respectively, and a 3.2-, 5.2-, and 7.0-percentage unit decrease in PR, probability of pregnancy, and PRFS, respectively. Herds above the herd-alarm levels for postpartum Hp had a 5.3-percentage unit increase in disorder incidence. At the cow level and herd level, elevated biomarker concentrations were associated with an increased disorder risk and varied performance responses.


Assuntos
Doenças dos Bovinos , Cetose , Gastropatias , Ácido 3-Hidroxibutírico , Animais , Biomarcadores , Bovinos , Ácidos Graxos não Esterificados , Feminino , Haptoglobinas/análise , Inflamação/veterinária , Cetose/veterinária , Lactação/fisiologia , Leite/química , Período Pós-Parto , Gravidez , Estudos Prospectivos , Reprodução , Gastropatias/veterinária
20.
J Infect Dev Ctries ; 16(3): 516-521, 2022 03 31.
Artigo em Inglês | MEDLINE | ID: mdl-35404858

RESUMO

INTRODUCTION: Besides stomach, the oral cavity is the second reservoir of Helicobacter pylori (H. pylori) that plays an important role in oral diseases and recurrent gastric infection. This study aimed to determine the risk factors of oral H. pylori infection for better human health. METHODOLOGY: Saliva samples from 280 subjects who visited the dental clinics were collected for the H. pylori antigen test. The data regarding age, gender, residence, frequency of tooth brushing, presence of dental caries and/or periodontitis were reported for each participant. Stool antigen Helicobacter pylori test was used to detect gastric infection. RESULTS: The overall prevalence of H. pylori in oral cavity and stool were 40.4%; 95% CI [34.8-46.2], and 36.4%; 95% CI [31-42.2], respectively and were not statistically significant (p = 0.546). The differences of positive rates of H. pylori infection according to the presence of periodontitis (54.7% vs 30.1%, p < 0.001, OR; 95% CI: 2.8 (1.7-4.6)) and dental caries (47.1% vs 32%, p = 0.001, OR; 95% CI: 2.2 (1.3-3.5)) were statistically significant. Living in rural areas increases the risk of acquiring H. pylori infection compared with urban areas (46.9% vs 34.7%, p < 0.001, OR; 95% CI: 0.6 (0.4-1)). CONCLUSIONS: The H. pylori antigen test on saliva could be used as evidence of gastric infection. Oral diseases including periodontal diseases and caries are important risk factors for H. pylori colonization, so the professional treatment of these diseases may reduce the rate of new and recurrent gastric infection by H. pylori.


Assuntos
Cárie Dentária , Infecções por Helicobacter , Helicobacter pylori , Gastropatias , Antígenos de Bactérias , Estudos Transversais , Cárie Dentária/epidemiologia , Infecções por Helicobacter/complicações , Infecções por Helicobacter/diagnóstico , Infecções por Helicobacter/epidemiologia , Humanos , Fatores de Risco , Saliva
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