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1.
Exp Neurol ; 347: 113889, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34624330

RESUMO

Spinal cord injury (SCI) leads to irreversible functional deficits due to the disruption of axons and the death of neurons and glial cells. The inflammatory response that occurs in the injured spinal cord results in tissue degeneration; thus, targeting inflammation after acute SCI is expected to ameliorate histopathological evidence indicative of damage and, consequently, reduce functional disabilities. Interleukin 1 beta (IL-1ß) and interleukin 18 (IL-18) are pro-inflammatory cytokines members of the IL-1 family that initiate and propagate inflammation. Here, we report that protein levels of IL-1ß and IL-18 were increased in spinal cord parenchyma after SCI, but with different expression profiles. Whereas levels of IL-1ß were rapidly increased reaching peak levels at 12 h after the injury, levels of IL-18 did not increase until 7 days after the injury. Since activation of the NLRP3 inflammasome is required for the processing and release of IL-1ß and IL-18, we intraperitoneally administered OLT1177, a selective inhibitor of the NLRP3 inflammasome, to reduce the contribution of these cytokines to SCI. At a dose of 200 mg/kg, OLT1177 protected against neurological deficits and histological evidence of damage. OLT1177 also reduced the levels of IL-1ß in the spinal cord after contusion injury and diminished the accumulation of neutrophils and macrophages at later time points. These data suggest that targeting the NLRP3 inflammasome with OLT1177 could be a novel therapeutic strategy to arrest neuroinflammation and reduce functional impairments after acute SCI in humans.


Assuntos
Anti-Inflamatórios/farmacologia , Inflamassomos/efeitos dos fármacos , Bainha de Mielina/patologia , Nitrilas/farmacologia , Traumatismos da Medula Espinal/imunologia , Sulfonas/farmacologia , Animais , Feminino , Camundongos , Proteína 3 que Contém Domínio de Pirina da Família NLR/imunologia , /patologia , Traumatismos da Medula Espinal/patologia
2.
Chemosphere ; 288(Pt 1): 132405, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34597639

RESUMO

In this study, Kaolin clay, a mining material, was used as an abundant and available mineral as zero-valent iron-kaolinite composites for As2O3 removal from the water samples. The composites were made by the sodium borohydrate reduction method. The existence of Fe0 in the produced composites was confirmed by X-ray diffraction (XRD) and Fourier-Transform Infrared Spectroscopy (FTIR) analysis. The membranes are prepared with zerovalent nano Iron-Kaolin and PES. The synthesized composites were then mixed with polyethersulfone to prepare the membranes S1, S2, and S3 with varying compositions. Field Emission Scanning Electron Microscopy (FESEM) analysis of the produced membranes showed the porous structure and the contact angle of membranes increased the hydrophilicity. The membranes were explored for the removal of As2O3 (AsIII) in potable water samples. The filtration studies were carried out using the syringe filtration setup. Analysis of the arsenic (III) solution was carried out, before and after the filtration process using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES), which showed a maximum of 50% reduction in its original concentration. The filtered membrane is analyzed for arsenic by Energy Dispersive X-ray (EDX) technique. Thus, the synthesized membrane effectively sieves the arsenic in water samples.


Assuntos
Água Potável , Poluentes Químicos da Água , Purificação da Água , Adsorção , Argila , Ferro , Caulim , Cinética , Polímeros , Sulfonas , Poluentes Químicos da Água/análise
3.
Chemosphere ; 286(Pt 1): 131616, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34325268

RESUMO

Membrane fouling is one of the challenging bottleneck problems in waste water treatment by membrane process. The present study constructed a nanofiltration membrane based on the zinc oxide nanoparticle (n-ZnO) integrated Poly(ether ether sulfone) (PEES) membranes. The developed membranes were characterized by X-ray diffraction (XRD), attenuated total reflectance - fourier transform infrared spectroscopy (AT-FTIR), atomic force microscopy (AFM) and scanning electron microscope (SEM) coupled with energy dispersive X-ray (EDX) analysis. Pure water flux, contact angle, molecular weight cut-off, mean pore size and porosity were determined to investigate the influence of n-ZnO on the properties of the membranes. The characterization showed asymmetric configuration of membranes after n-ZnO incorporation. This incorporation also enhanced the hydrophilicity of PEES membrane. The fouling-resistant potential of the membranes was investigated by the model foulant humic acid (HA) and an enhanced anti-fouling irreversible property with a corresponding flux recovery rate of 92.43 % was noted for the prepared membrane. The rejection performance and permeability of HA was 98.03 % and 166.73 L m-2 h-1, respectively, owing to the hydrophilic nature of ZnO particles. Further, modified PEES membrane exhibited superior separation performance for monovalent and divalent anions. PEES/n-ZnO hybrid membrane assisted nanofiltration is an effective process for the improvement of membrane performance and anti-fouling property, demonstrating its immense use in water reclamation.


Assuntos
Incrustação Biológica , Nanopartículas , Óxido de Zinco , Incrustação Biológica/prevenção & controle , Éter , Éteres , Membranas Artificiais , Sulfonas
4.
J Hazard Mater ; 421: 126744, 2022 01 05.
Artigo em Inglês | MEDLINE | ID: mdl-34333408

RESUMO

To meet the rising global demand for water, it is necessary to develop membranes capable of efficiently purifying contaminated water sources. Herein, we report a series of novel polysulfone (PSf)/GO-vanillin nanofiltration membranes highly permeable, selective, and fouling resistant. The membranes are composed of two-dimensional (2D) graphite oxide (GO) layers embedded with vanillin as porogen and PSf as the base polymer. There is a growing interest in addressing the synergistic effect of GO and vanillin on improving the permeability and antifouling characteristics of membranes. Various spectroscopic and microscopic techniques were used to perform detailed physicochemical and morphological analyses. The optimized PSf16/GO0.15-vanillin0.8 membrane demonstrated 92.5% and 25.4% rejection rate for 2000 ppm magnesium sulphate (MgSO4) and sodium chloride (NaCl) solutions respectively. Antifouling results showed over 99% rejection for BSA and 93.57% flux recovery ratio (FRR). Experimental work evaluated the antifouling characteristics of prepared membranes to treat landfill leachate wastewater. The results showed 84-90% rejection for magnesium (Mg+2) and calcium (Ca+2) with 90.32 FRR. The study experimentally demonstrated that adding GO and vanillin to the polymeric matrix significantly improves fouling resistance and membrane performance. Future research will focus on molecular sieving for industrial separations and other niche applications using mixed matrix membranes.


Assuntos
Grafite , Purificação da Água , Benzaldeídos , Membranas Artificiais , Óxidos , Polímeros , Sulfonas
5.
Ecotoxicol Environ Saf ; 229: 113102, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34942420

RESUMO

This study investigates the adverse effects and the associated underlying mechanism of bisphenol S (BPS) exposure on reproductive endocrine activity in adult zebrafish. Fish were exposed for 21 days to different BPS concentrations (0, 8, 40, and 200 µg/mL) determined via the lowest observed adverse effect level (LOAEL, i.e., < EC15 = 250 µg/mL) for zebrafish embryos. Exposure to 200 µg/mL BPS in female zebrafish in the absence of vitellogenic oocytes or the presence of degenerated oocytes in the ovary significantly decreased the biosynthesis of hepatic vitellogenin (VTG) mRNA, while hepatic VTG mRNA in male fish abundance was significantly elevated (P < 0.05). The levels of gonadal steroids were significantly increased in female zebrafish, while in male zebrafish, the levels of endogenous androgens were reduced (P < 0.05). However, the activities of 17ß-estradiol and aromatase in male zebrafish were significantly elevated in all BPS exposure groups in male zebrafish (P < 0.05). Interestingly, thyroid hormone levels and residual whole-body BPS levels increased in female and male zebrafish with increasing exposure concentrations. A novel finding is that the response to BPS depends on zebrafish sex and tissue-specific responsiveness to the accumulation of BPS, suggesting that BPS may cause long-term environmental problems in adult zebrafish through tissue-specific suppression and hormonal imbalance.


Assuntos
Poluentes Químicos da Água , Peixe-Zebra , Animais , Feminino , Masculino , Fenóis/toxicidade , Sulfonas , Vitelogeninas/genética , Poluentes Químicos da Água/toxicidade
6.
Ecotoxicol Environ Saf ; 229: 113096, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34952380

RESUMO

Bisphenol A (BPA), an endocrine disruptor, has been replaced by structural analogues including bisphenol S (BPS). BPA and BPS exhibited similar effects regarding reproductive functions. Moreover, metabolic status and lipid metabolism are related to female fertility and could worsen BPS effects. The objective was to determine BPS in vivo effects on folliculogenesis and embryo production after chronic exposure through diet, and the influence of metabolic status in adult ewes. Sixty primiparous 2.5 year-old ewes, undergoing a restricted or well fed diet, were exposed to BPS (0, 4 or 50 µg/kg/day) for at least three months. After hormonal oestrus synchronisation and ovarian stimulation, ewes were subjected to ovum pick-up (OPU) procedures to collect immature oocytes, that underwent in vitro maturation, fertilisation and embryo production. Body weight, body condition score and plasma glucose were higher in well-fed compared to restricted ewes, while plasma NEFA was lower during the 4-5 months after the beginning of the diets. Plasma progesterone levels increased on day 5 before OPU session in well-fed compared to restricted ewes. No effect of BPS dose was observed on follicle population, plasma AMH levels and embryo production numbers and rates. However, a significant diet x BPS dose interaction was reported for cleaved embryos, > 4-cell embryos, blastocyst and early blastocyst numbers, and plasma triiodothyronine levels. Our study showed that a contrasted diet did not affect follicle population nor embryo production in adult ewes but could affect the quality and progesterone secretion of the corpus luteum. Chronic low BPS exposure had no effect on follicular population and oocyte competence. Nevertheless, the significant diet x dose interactions observed on embryo production suggest that BPS effect is modulated by metabolic status. Further studies are required to assess the risk of BPS exposure for public reproductive health.


Assuntos
Oócitos , Sulfonas , Animais , Dieta/veterinária , Embrião de Mamíferos , Feminino , Fenóis , Ovinos
7.
Methods Mol Biol ; 2368: 233-239, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34647259

RESUMO

Polyethersulfone (PES) membranes provide a versatile tool for gravity-related plant studies. Benefits of this system include straightforward setup, no need for specialized equipment, long-term seed viability between plating and hydration/growth, and adaptability to diverse protocols and downstream analyses. Methods outlined here include seed sterilization, planting, growth, and dissection that will transition directly into any RNA extraction protocol.


Assuntos
Arabidopsis , Proteínas de Arabidopsis , Dissecação , Gravitropismo , Raízes de Plantas , Polímeros , Sulfonas
8.
Talanta ; 236: 122859, 2022 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-34635243

RESUMO

The sensitivity and selectivity of electrochemical analysis are challenging due to the materials used for electrode modification as well as electrical conductivity, catalytic activity and recognition ability of the working electrode. In this work, a portable 3D-printed electrochemical electrode clamp was designed and applied in combination with the developed covalent organic framework (COF DQTP)-modified pencil graphite electrode (DQTP/PGE). The ß-ketoenamine-linked COF DQTP synthesized by 1,3,5-triformylphloroglucinol (TP) and 2,6-diaminoanthraquinone (DQ) through solvothermal method is a porous crystalline with excellent conductivity and large periodic π-arrays, coupled with commercial available pencil graphite electrode to fabricate a disposable sensor for simultaneous determination of environmental endocrine disruptors bisphenol A and bisphenol S. The DQTP/PGE sensor exhibited high electrical conductivity and catalytic activity, and a good linearity was obtained in a range of 0.5-30 µM for two bisphenols with a detection limit of 0.15 µM (S/N = 3). Moreover, the sensor showed a reproducible and stable response over one month with negligible interference, and an accepted recovery with real food packaging samples.


Assuntos
Grafite , Estruturas Metalorgânicas , Compostos Benzidrílicos , Eletrodos , Fenóis , Sulfonas
9.
J Hazard Mater ; 421: 126788, 2022 01 05.
Artigo em Inglês | MEDLINE | ID: mdl-34364204

RESUMO

Development of efficient absorbent materials for oil spillage clean-up and environmental pollution remediation is highly desired but remains a challenge. In this work, superhydrophobic/superoleophilic polysulfone based ZIF-7 composite (SPZ) foams were fabricated via chemical modification of polysulfone and integrating with hydrophobic coin-shaped ZIF-7 particles. The synergistic approaches provided the SPZ foams with high porosity, low density and superhydrophobic/superoleophilic features (θwater=162.3°, θoil=0°) and outstanding self-cleaning property. The as-prepared SPZ foams exhibited highly selective absorption capacity (up to 3800 wt%) for various kinds of oils and organic solvents. Furthermore, the SPZ foams still maintained 95.2% of its pristine absorption capacity and the θwater remained at 143.6° after ten absorption/distillation cycles. The SPZ foam showed outstanding separation ability towards different types of emulsions with separation efficiency all above 97%. The high oil/water separation efficiency and robust reusability made the SPZ foams promising absorbent in dealing with practical oil spills.


Assuntos
Poluição por Petróleo , Água , Interações Hidrofóbicas e Hidrofílicas , Óleos , Polímeros , Sulfonas
10.
Food Chem ; 367: 130758, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34391995

RESUMO

This study evaluated the chemical behaviour of Bisphenol S (BPS) and determined its bioaccessibility after human ingestion using a standardised in vitro gastrointestinal digestion protocol and an analytical method based on high-pressure liquid chromatography coupled with a photodiode array and tandem mass spectrometry. The effects of different factors such as gastric pH, enzymes, and food matrix on the solubility and chemical stability of BPS were studied to evaluate their contribution to its bioaccessibility. The results highlighted that BPS was available at the end of the digestion process in the range of 50-80%, and was susceptible to absorption at the intestinal level. The effect of pH was not significant as a single factor. The presence of enzymes slightly decreased the bioaccessibility of BPS in the intestinal phase with gastric pH increase. Additionally, a soy drink reduced BPS bioaccessibility by up to 5% after oral intake. Finally, a few BPS degradation products were found in non-bioaccessible fractions at different pH values.


Assuntos
Fenóis , Espectrometria de Massas em Tandem , Disponibilidade Biológica , Cromatografia Líquida de Alta Pressão , Digestão , Humanos , Sulfonas
11.
Chemosphere ; 286(Pt 2): 131797, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34426121

RESUMO

A photocatalyst composed of Zn-TiO2 and Cu-TiO2 through simple physical mixing was used to activate persulfate(PS) for Bisphenol S (BPS) degradation. Zn-TiO2 and Cu-TiO2 were prepared with a sol gel method and were characterized by X-ray diffraction (XRD), Raman, Transmission electron microscope (TEM), Fourier-transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). The two catalysts have shown an obvious synergistic effect in the photocatalytic degradation process. When 5 mM persulfate and 0.3 g/L catalyst were used, the removal rate of mixed catalyst (0.2 g/L Zn-TiO2 and 0.1 g/L Cu-TiO2) is 100 % in 18 min, which is significantly better than that of 0.3 g/L Zn-TiO2(58 %) and 0.3 g/L Cu-TiO2(90 %). Typically, the effects of various operation parameters, including the ratio of Cu-TiO2/Zn-TiO2, catalyst dosage, persulfate dosage, initial concentration of BPS, and initial solution pH, were examined. Reactive oxygen species (ROS) in the UV/mixed catalyst/PS process was identified by scavenger and electron paramagnetic resonance (EPR) tests. The superoxide radicals generated by both Zn-TiO2 and the hydrolysis of persulfate in the system could accelerate the Cu (II)/Cu(I) redox cycles and results in the synergistic effect. This study proposed a new and effective way to improve the reaction by simply combining two catalysts, and unraveled the mechanism behind the synergistic effect, which could provide new ideas to use the catalyst more effectively for wastewater treatment or other areas.


Assuntos
Titânio , Zinco , Catálise , Fenóis , Sulfonas , Difração de Raios X
12.
Water Sci Technol ; 84(12): 3576-3585, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34928827

RESUMO

Ultrafiltration membranes can intercept oil particles smaller than 10 µm, but the membranes are easily contaminated by oil due to their hydrophobicity. To treat various oily wastewaters, we prepared a hydrophilic hollow fiber membrane (HFM) with anti-fouling property by grafting sulfobetaine methacrylate (SBMA) onto polysulfone (PSU). For six simulated wastewaters containing emulsified oil at 1,000 mg/L, the PSU-g-SBMA HFM was able to remove 98.5-99.7% of oil, higher than that of PSU HFM at 91.1-98.9%. The oil concentration in filtrate was less than 15 mg/L, which could meet the discharge standard of wastewater. The water flux of PSU-g-SBMA HFM can be completely recovered after being washed by rhamnolipid and alkali solution, while the same cleaning process could not recover the PSU HFM. As found, the contact angles of oil droplets on the PSU-g-SBMA membrane were larger than those on PSU membrane, which indicated the improved hydrophilicity by PSU-g-SBMA. For 48 h of filtration to soybean and diesel oil/water emulsion, the effect of PSU-g-SBMA HFM was stable and the flux could be completely recovered by cleaning. Therefore, we provided a new method for oily wastewater treatment, which can efficiently and energy-saving remove various oil substances in wastewater.


Assuntos
Águas Residuárias , Purificação da Água , Betaína/análogos & derivados , Metacrilatos , Polímeros , Sulfonas
13.
J Agric Food Chem ; 69(44): 12974-12984, 2021 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-34723494

RESUMO

Fluensulfone (FSF) becomes increasingly popular because of its nonfumigation application method. However, studies on the metabolic mechanism of FSF in plants are lacking. Here, tomato seedling was cultivated in hydroponic media to investigate the connection among FSF's metabolism in tomato, the regulation of tomato endogenous glycosides, and the elimination of hydrogen peroxide in tomato cells. The accumulation of FSF was only detected in the lower stems of tomatoes; FSF was mainly metabolized into S-glycosylated conjugates in the roots, and the roots were the tissues with the highest metabolite content; and no FSF and metabolites were detected in the upper leaves. In response to FSF stress (2 mg/L for 7 d), the content of sugar and glycosides in the stems of tomato seedlings significantly increased. The amount of some compounds on the pathway related to glucose was affected by FSF. The three precursor compounds (homomethioine, isoleucine, and l-tyrosine) in the pathway of glucosinolate biosynthesis increased significantly under the stress of FSF, which indicates that FSF may compete with them for UGT74B1. Besides, FSF-induced flavonoid glycosides may play a role in the process of removing hydrogen peroxide. This research provides inspiration for the fate of many xenobiotics containing sulfonyl groups in plants.


Assuntos
Lycopersicon esculentum , Glicosilação , Plântula , Sulfonas , Tiazóis
14.
Environ Toxicol Pharmacol ; 88: 103751, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34624477

RESUMO

Although the toxicity of bisphenol S has been studied in some species, the global metabolic network disrupted by bisphenol S remains unclear. To this end, published datasets related to the genes, proteins, and metabolites disturbed by bisphenol S were investigated through omics methods. The dataset revealed that bisphenol S at high concentrations tended to downregulate biomolecules, while low concentrations of bisphenol S tended to enhance metabolic reactions. The results showed that exposure to bisphenol S upregulated estrogen and downregulated androgen metabolism in humans, mice, rats, and zebrafish. Fatty acid metabolism and phospholipid metabolism in mice were upregulated. Reactions in amino acid metabolism were upregulated, with the exception of the suppressive conversion of arginine to ornithine. In zebrafish, fatty acid synthesis was promoted, while nucleotide metabolism was primarily depressed through the downregulation of pyruvate 2-o-phosphotransferase. The interference in amino acid metabolism by bisphenol S could trigger Alzheimer's disease, while its disturbance of glucose metabolism was associated with type II diabetes. Disturbed glycolipid metabolism and vitamin metabolism could induce Alzheimer's disease and diabetes. These findings based on omics data provide scientific insight into the metabolic network regulated by bisphenol S and the diseases triggered by its metabolic disruption.


Assuntos
Redes e Vias Metabólicas/efeitos dos fármacos , Fenóis/toxicidade , Sulfonas/toxicidade , Doença de Alzheimer , Aminoácidos/metabolismo , Animais , Colesterol/metabolismo , Diabetes Mellitus Tipo 2 , Ésteres/metabolismo , Ácidos Graxos/metabolismo , Feminino , Genômica , Glucose/metabolismo , Humanos , Metabolismo dos Lipídeos , Masculino , Metabolômica , Camundongos , Fosfolipídeos/metabolismo , Ratos , Suínos , Vitaminas/metabolismo , Peixe-Zebra
15.
Indian Heart J ; 73(5): 633-636, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34627582

RESUMO

Pulmonary arterial hypertension (PAH) - a complex and progressive disease that carries significant morbidity and mortality despite optimal medical treatment. Combination therapy for PAH can be more effective than monotherapy. The present randomized trial compared the safety and efficacy of sildenafil ambrisentan combination therapy with sildenafil monotherapy. Twenty-two patients of Eisenmenger syndrome and five patients of idiopathic PAH were randomized to two arms. There was a significant improvement in NYHA functional class and mean pulmonary artery pressure, while an insignificant improving trend was observed for 6-min walk distance and oxygen saturation, following the 12 weeks of combination therapy. An upfront combination therapy was found to be safe and effective in the management of PAH patients.


Assuntos
Complexo de Eisenmenger , Hipertensão Pulmonar , Anti-Hipertensivos/uso terapêutico , Método Duplo-Cego , Quimioterapia Combinada , Complexo de Eisenmenger/complicações , Complexo de Eisenmenger/diagnóstico , Complexo de Eisenmenger/tratamento farmacológico , Humanos , Hipertensão Pulmonar/diagnóstico , Hipertensão Pulmonar/tratamento farmacológico , Fenilpropionatos , Piperazinas/uso terapêutico , Purinas/uso terapêutico , Piridazinas , Citrato de Sildenafila/uso terapêutico , Sulfonas/uso terapêutico , Resultado do Tratamento
16.
J Environ Manage ; 300: 113809, 2021 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-34649317

RESUMO

A highly efficient nanofiltration membrane should exhibit high separation performance in removing divalent salts and organic solutes, as well as high permeation to meet practical separation and purification applications in aqueous media. Here, we designed a series of hybrid multilayer thin film membranes filled with the structurally and morphologically different nanofillers such as hexagonal boron nitride (HBN) nanosheets and metal-organic framework (MOF) nanoparticles, consisting of 3 and 6 layer pairs of polyelectrolyte through the layer-by-layer self-assembly technique (LBL) and characterized them in terms of dye and salt separation, as well as permeation. The rejection performance and permeability of the designed membranes manifested that HBN nanosheets were more effective than MOF nanoparticles in achieving a high-performance membrane. As compared to the bare multilayer thin film membrane, the addition of HBN nanosheets within the negatively-charged layers of the multilayer thin film membrane consisting of 6 bilayers resulted in good retention of up to 93% and 92% for acid blue (ACB) and bromophenol blue (BPB) dye molecules, respectively. Besides, this membrane exhibited 60% and 45% improvement in the water flux for ACB and BPB solutions, respectively, while the rejection of the sulfate ions maintained an acceptable value around 78%. Furthermore, it was found that this HBN-embedded hybrid multilayer membrane had superior potential for the removal of coherent foulant compared to all samples.


Assuntos
Padrões Moleculares Associados a Patógenos , Polímeros , Membranas Artificiais , Sulfonas
17.
Nutrients ; 13(10)2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34684621

RESUMO

Interventions to decrease inflammation and improve metabolic function hold promise for the prevention of obesity-related diseases. Methylsulfonylmethane (MSM) is a naturally occurring compound that demonstrates antioxidant and anti-inflammatory effects. Improvements in measures of metabolic health have been observed in mouse models of obesity and diabetes following MSM treatment. However, the effects of MSM on obesity-related diseases in humans have not been investigated. Therefore, the purpose of this investigation was to determine whether MSM supplementation improves cardiometabolic health, and markers of inflammation and oxidative status. A randomized, double-blind, placebo-controlled design was utilized with a total of 22 overweight or obese adults completing the study. Participants received either a placebo (white rice flour) or 3 g MSM daily for 16 weeks. Measurements occurred at baseline and after 4, 8, and 16 weeks. Outcome measures included fasting glucose, insulin, blood lipids, blood pressure, body composition, metabolic rate, and markers of inflammation and oxidative status. The primary finding of this work shows that high-density lipoprotein cholesterol was elevated at 8 and 16 weeks of daily MSM consumption compared to baseline, (p = 0.008, p = 0.013). Our findings indicate that MSM supplementation may improve the cholesterol profile by resulting in higher levels of high-density lipoprotein cholesterol.


Assuntos
HDL-Colesterol/sangue , Dimetil Sulfóxido/farmacologia , Obesidade/sangue , Sulfonas/farmacologia , Adulto , Biomarcadores/sangue , Proteína C-Reativa/metabolismo , Dieta , Dimetil Sulfóxido/sangue , Exercício Físico , Feminino , Fibrose , Humanos , Inflamação/sangue , Inflamação/patologia , Masculino , Oxirredução , Sulfonas/sangue
18.
Chem Commun (Camb) ; 57(72): 9140-9143, 2021 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-34498639

RESUMO

The hydrosulfamoylation of diverse aryl olefins provides facile access to alkylsulfonamides. Here we report a novel protocol utilizing radical-mediated addition and a thiol-assisted strategy to achieve the hydrosulfamoylation of diverse styrenes in modest to excellent yields under mild and economic reaction conditions. The methodology was found to provide an efficient and convenient approach for the synthesis of the anti-migraine drug naratriptan and it also can be used for the late-stage functionalization of natural products or medicines.


Assuntos
Piperidinas/síntese química , Estirenos/química , Sulfonas/química , Triptaminas/síntese química , Catálise , Estrutura Molecular , Oxirredução , Processos Fotoquímicos , Piperidinas/química , Triptaminas/química
19.
J Phys Chem B ; 125(40): 11242-11255, 2021 10 14.
Artigo em Inglês | MEDLINE | ID: mdl-34586817

RESUMO

A many-body polarizable force field (PFF) was developed for molecular dynamics (MD) simulations of sulfone-based solvents and lithium salts. Development of the polarizable force field included parameterization of atomic polarizabilities, electrostatic interactions, and van der Waals interactions of electrolyte components. 1λ6-thiolane-1,1-dione or sulfolane (SLF) compound was selected as one of the most appropriate solvents for high-voltage battery electrolytes. Atomic polarizabilities for the sulfolane solvent and lithium salts were obtained by means of a combination of quantum mechanics (QM) and molecular mechanics (MM) approaches using the isotropic atomic dipole polarizable (IADP) model. High-quality atomic polarizabilities were refined for 10 atomic types. Intermolecular interactions of Li+ ions with SLF were parameterized to reproduce the binding energies at the MP2/aug-cc-pvDZ level of theory in the gas phase. Intermolecular interactions of Li+ ions with polyatomic anions, such as nitrate [NO3]-, tetrafluoroborate [BF4]-, perchlorate [ClO4]-, hexafluorophosphate [PF6]-, bis(fluorosulfonyl)imide [FSI]-, and bis(trifluoromethylsulfonyl)imide [TFSI]-, were parameterized employing a similar methodology. A series of molecular dynamics simulations was performed for sulfolane-based electrolytes at several different lithium salt concentrations. Thermodynamic, structural, and transport properties were evaluated to validate the force field parameters against available simulation and experimental data. Transport properties of sulfolane were significantly improved as compared with those obtained from MD simulations using a nonpolarizable force field (NFF). A newly developed polarizable potential was shown to reproduce Li+ ion dynamics as a function of salt concentration. Faster diffusion of Li+ ions, among other electrolyte components, was obtained for high salt concentration electrolytes.


Assuntos
Lítio , Simulação de Dinâmica Molecular , Eletrólitos , Íons , Sais , Solventes , Sulfonas
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