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1.
Proc Biol Sci ; 289(1974): 20220532, 2022 05 11.
Artigo em Inglês | MEDLINE | ID: mdl-35506222

RESUMO

Rapid exaggeration of host and pathogen traits via arms race dynamics is one possible outcome of host-pathogen coevolution. However, the exaggerated traits are expected to incur costs in terms of resource investment in other life-history traits. The current study investigated the costs associated with evolved traits in a host-pathogen coevolution system. We used the Drosophila melanogaster (host)-Pseudomonas entomophila (pathogen) system to experimentally derive two selection regimes, one where the host and pathogen both coevolved, and the other, where only the host evolved against a non-evolving pathogen. After 17 generations of selection, we found that hosts from both selected populations had better post-infection survivorship than controls. Even though the coevolving populations tended to have better survivorship post-infection, we found no clear evidence that the two selection regimes were significantly different from each other. There was weak evidence for the coevolving pathogens being more virulent than the ancestral pathogen. We found no major cost of increased post-infection survivorship. The costs were not different between the coevolving hosts and the hosts evolving against a non-evolving pathogen. We found no evolved costs in the coevolving pathogens. Thus, our results suggest that increased host immunity and pathogen virulence may not be costly.


Assuntos
Drosophila melanogaster , Sobrevivência , Animais , Pseudomonas , Sobrevida
2.
BMC Nephrol ; 23(1): 193, 2022 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-35606716

RESUMO

BACKGROUND: Despite the high economic and mortality burden of chronic kidney disease, studies on survival and predictors of mortality among patients on hemodialysis in Ethiopia especially in the Amhara region are scarce considering their importance to identify some modifiable risk factors for early mortality to improve the patient's prognosis. So, this study was done to fill the identified gaps. The study aimed to assess survival and predictors of mortality among end-stage renal disease patients on hemodialysis in Amhara regional state, Ethiopia, 2020/2021. METHOD: Institution-based retrospective record review was conducted in Felege Hiwot, Gonder, and Gambi hospitals from March 5 to April 5, 2021. A total of 436 medical records were selected using a simple random sampling technique. A life table was used to estimate probabilities of survival at different time intervals. Multivariable cox regression was used to identify risk factors for mortality. RESULT: Out of the 436 patients 153 (35.1%) had died. The median survival time was 345 days with a mortality rate of 1.89 per 1000 person-days (95%CI (1.62, 2.22)). Patients live in rural residences (AHR = 1.48, 95%CI (1.04, 2.12)), patients whose cause of CKD was hypertension (AHR = 1.49, 95%CI (1.01, 2.23)) and human immune virus (AHR = 2.22, 95%CI (1.41, 3.51)), and patients who use a central venous catheter (AHR = 3.15, 95%CI (2.08, 4.77)) had increased risk of death while staying 4 h on hemodialysis (AHR = 0.43, 95%CI (0.23, 0.80)) decreases the risk of death among chronic kidney disease patients on hemodialysis. CONCLUSIONS: The overall survival rate and median survival time of chronic kidney disease patients on hemodialysis were low in the Amhara region as compared with other developing Sub-Saharan African counties.


Assuntos
Insuficiência Renal Crônica , Etiópia/epidemiologia , Humanos , Diálise Renal , Insuficiência Renal Crônica/mortalidade , Insuficiência Renal Crônica/terapia , Estudos Retrospectivos , Fatores de Risco , Sobrevida
4.
Oncología (Ecuador) ; 32(1): 40-54, 30-04-2022.
Artigo em Espanhol | LILACS | ID: biblio-1368943

RESUMO

Introducción: La relación entre supervivencia e infiltración linfocitaria en el cáncer gástrico se ha determinado como factor pronóstico beneficioso, este estudio local tiene como objetivo determinar la probabilidad de supervivencia en los pacientes con cáncer gástrico estadios IB al IIIC de acuerdo con el porcentaje de infiltración linfocitaria tumoral. Metodología: El presente estudio longitudinal se realizó en el Hospital Oncológico Solón Espinosa Ayala Solca-Núcleo de Quito. El período de estudio de enero del 2013 a enero del 2016, el tiempo de seguimiento terminó en diciembre del 2018. El cálculo de la muestral fue no probabilístico en donde se incluyeron casos de pacientes mayores a 18 años con diagnóstico de cáncer gástrico con estadios clínicos IB al IIIC, que contaron con una muestra histopatológica de gastrectomías. Se usó la variable: "Porcentaje de infiltración" para el análisis la muestra y se dividió en 3 grupos: G1: infiltración linfocitaria leve, G2: moderada y G3: intensa. Las estimaciones de supervivencia se calcularon utilizando el método de Kaplan-Meier y la comparación entre los grupos con la prueba de rango logarítmico. Resultados: 173 pacientes con cáncer gástrico con estadios clínicos IB al IIIC, seguidos a 72 meses, el 60 % son hombres y el 40 % mujeres. Según el porcentaje de infiltración linfocitaria, el 52 % reportaron un porcentaje de infiltración leve, el 21 % moderada y el 27 % intensa. A los 72 meses de seguimiento la supervivencia en G1 fue del 31 %, en G2 fue del 48 %, y en G3 fue del 77 % (P= 0.001). Conclusión: Se encontró que el grado de infiltración linfocitaria intensa en los pacientes con cáncer gástrico estuvo asociado a una mejor supervivencia en el seguimiento a 72 meses.


Introduction: The relationship between survival and lymphocytic infiltration in gastric cancer has been determined to be a beneficial prognostic factor. This local study aims to assess the probability of survival in patients with gastric cancer stages IB to IIIC according to the percentage of lymphocytic infiltration. Methodology: This longitudinal study was conducted at the Solón Espinosa Ayala Solca-Núcleo Cancer Hospital in Quito. The study period was from January 2013 to January 2016; the follow-up time ended in December 2018. The sample calculation was nonprobabilistic and included cases of patients older than 18 diagnosed with gastric cancer with clinical stages IB at IIIC, which had a histo-pathological sample of gastrectomies. The variable "percentage of infiltration" was used to analyze the sample, and it was divided into three groups: G1: mild lymphocytic infiltration, G2: moderate, and G3: intense. Survival estimates were calculated using the Kaplan­Meier method and compared groups with the log-rank test. Results: A total of 173 patients with gastric cancer with clinical stages IB to IIIC were followed up for 72 months; 60% were men, and 40% were women. According to the percentage of lymphocytic infil-tration, 52% reported a rate of mild infiltration, 21% moderate, and 27% intense. At 72 months of follow-up, survival was 31% in G1, 48% in G2, and 77% in G3 (P= 0.001). Conclusion: The degree of intense lymphocytic infiltration in gastric cancer patients was associated with better survival at the 72-month follow-up.


Assuntos
Humanos , Adulto , Idoso , Neoplasias Gástricas , Sobrevida , Linfócitos do Interstício Tumoral , Biomarcadores Tumorais , Análise de Sobrevida
6.
Rev. argent. salud pública ; 14 (Suplemento COVID-19), 2022;14: 1-7, 02 Febrero 2022.
Artigo em Espanhol | LILACS, BINACIS, ARGMSAL | ID: biblio-1367409

RESUMO

INTRODUCCIÓN: Uno de los problemas que ha enfrentado el sistema de salud de los diferentes países debido a la pandemia de COVID-19 es la disponibilidad de servicios y atención médica en unidades de cuidados intensivos (UCI). El objetivo fue evaluar la sobrevida en pacientes internados por COVID-19 en UCI entre enero y abril de 2021 en la provincia de Buenos Aires, Argentina. MÉTODOS: Se consideró a los pacientes que, incluidos en el sistema de vigilancia, tuvieran su correlato de información del porcentaje ocupacional de camas de la UCI desde el sistema general. Con esta información se realizó un análisis de sobrevida, considerando tablas de vida, Kaplan-Meier y regresión de Cox. El evento fue el óbito, el tiempo de seguimiento a 96 días y las fechas de internación, defunción y egreso dentro de la UCI como períodos individuales de cada paciente. La capacidad operativa de las UCI fue medida a través del porcentaje de ocupación de camas al momento del ingreso. RESULTADOS: Las UCI con un porcentaje ocupacional mayor al 80% mostraron pacientes con menor curva de sobrevida que sus pares por debajo de esas cifras al momento de ingresar a la internación. DISCUSIÓN: Las diferencias en promedios de sobrevida son estadísticamente diferentes, y muestran dos curvas distintas de supervivencia en el momento en que la segunda ola de COVID-19 afectaba a la Argentina.


Assuntos
Argentina , Sobrevida , COVID-19 , Unidades de Terapia Intensiva
7.
Rev. Méd. Inst. Mex. Seguro Soc ; 60(1): 52-58, 17-feb-2022. ilus, tab
Artigo em Espanhol | LILACS | ID: biblio-1359848

RESUMO

Introducción: el conocimiento de la funcionalidad del injerto y la supervivencia del paciente es fundamental para valorar el éxito del trasplante renal. Objetivo: determinar la supervivencia de los pacientes trasplantados por tipo de donante y la funcionalidad de los injertos renales en una cohorte en México. Material y métodos: cohorte de trasplante renal de 2013 a 2017 en México. Se analizaron 790 pacientes seguidos por un año para valorar la supervivencia de los pacientes trasplantados por tipo de donante y la funcionalidad de los injertos renales. Para ello se usaron medidas de tendencia central y dispersión, así como tablas de supervivencia de Kaplan-Meier con SPSS, versión 25. Resultados: de los 790 pacientes, 518 fueron de donante vivo (65.56%) con supervivencia del paciente de 97.88% y de funcionalidad del injerto de 93.24% a 12 meses de seguimiento; 272 pacientes recibieron el injerto de donante fallecido con supervivencia del paciente de 91.18% y funcionalidad del injerto renal de 84.19%. Conclusiones: aún existe una diferencia de casi 5% en la supervivencia del paciente receptor de un donante vivo en referencia con un donante fallecido. Para la funcionalidad del injerto renal esta diferencia es > 7%. La donación cadavérica ha aumentado; sin embargo, incluso en cifras bajas es de aproximadamente el 35% en México


Background: Knowledge of the functionality of the graft and patient survival is essential to assess the success of kidney transplantation. Objective: To determine the survival of transplanted patients by type of donor and the functionality of kidney grafts in a cohort in Mexico. Material and methods: Kidney transplant cohort from 2013 to 2017 in Mexico. 790 patients followed up for one year were analyzed to assess the survival of transplanted patients by type of donor and the functionality of kidney grafts. For this, measures of central tendency and dispersion were used, as well as Kaplan-Meier survival tables with SPSS, version 25. Results: Out of the 790 patients, 518 were from living donors (65.56%) with patient survival of 97.88% and graft function of 93.24% at 12 months of follow-up; 272 patients received the graft from a deceased donor with patient survival of 91.18% and renal graft function of 84.19%. Conclusions: There is still a difference of almost 5% in the survival of the recipient patient from a living donor compared to a deceased donor. For the functionality of the kidney graft, this difference is > 7%. Cadaveric donation has increased; however, even at low figures is of approximately 35% in Mexico


Assuntos
Humanos , Masculino , Feminino , Gravidez , Adulto , Pessoa de Meia-Idade , Sobrevida , Transplante de Rim , Assistência ao Convalescente , Sobrevivência , Sobrevivência de Enxerto , Estudos de Coortes , México
8.
Aging (Albany NY) ; 14(1): 389-409, 2022 01 12.
Artigo em Inglês | MEDLINE | ID: mdl-35021154

RESUMO

Chordin-like 1 (CHRDL1), an inhibitor of bone morphogenetic proteins(BMPs), has been recently reported to participate in the progression of numerous tumors, however, its role in lung adenocarcinoma (LUAD) remains unclear. Our study aimed to demonstrate relationship between CHRDL1 and LUAD based on data from The Cancer Genome Atlas (TCGA). Among them, CHRDL1 expression revealed promising power for distinguishing LUAD tissues form normal sample. Low CHRDL1 was correlated with poor clinicopathologic features, including high T stage (OR=0.45, P<0.001), high N stage (OR=0.57, P<0.003), bad treatment effect (OR=0.64, P=0.047), positive tumor status (OR=0.63, P=0.018), and TP53 mutation (OR=0.49, P<0.001). The survival curve illustrated that low CHRDL1 was significantly correlative with a poor overall survival (HR=0.60, P<0.001). At multivariate Cox regression analysis, CHRDL1 remained independently correlative with overall survival. GSEA identified that the CHRDL1 expression was related to cell cycle and immunoregulation. Immune infiltration analysis suggested that CHRDL1 was significantly correlative with 7 kinds of immune cells. Immunohistochemical validation showed that CHRDL1 was abnormally elevated and negatively correlated with Th2 cells in LUAD tissues. In conclusion, CHRDL1 might become a novel prognostic biomarker and therapy target in LUAD. Moreover, CHRDL1 may improve the effectiveness of immunotherapy by regulating immune infiltration.


Assuntos
Adenocarcinoma de Pulmão/metabolismo , Bases de Dados Genéticas , Proteínas do Olho/metabolismo , Proteínas do Tecido Nervoso/metabolismo , Idoso , Biomarcadores Tumorais , Proteínas do Olho/genética , Feminino , Regulação Neoplásica da Expressão Gênica , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Proteínas do Tecido Nervoso/genética , Transdução de Sinais , Sobrevida , Células Th2
9.
Sci Rep ; 12(1): 220, 2022 01 07.
Artigo em Inglês | MEDLINE | ID: mdl-34997151

RESUMO

Male breast cancer (MBC) is rare. Due to limited information, MBC has always been understudied. We conducted a retrospective population-based cohort study using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program. The clinical and biological features of female breast cancer (FBC) patients were compared with MBC patients. Cox regression models and competing risks analyses were used to identify risk factors associated with cancer-related survival in MBC and FBC groups. Results showed that MBC patients suffered from higher TNM stages, tumor grades, and a higher percentage of hormone receptor-positive tumors, compared with FBC patients (all p < 0.05). In addition, the breast tumor locations varied a lot between males and females (p < 0.05). FBC patients were associated with superior overall survival than MBC patients. Results from multivariate cox regression and competing risks analyses showed age, race, T, N, M-stages, tumor grades, estrogen receptor (ER)/progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2) overexpression were independent prognosis factors in FBC patients (all p < 0.05). MBC patients had similar risk factors to FBC patients, but PR and HER-2 status did not independently influence survival (all p > 0.05). Tumor location was an independent prognostic factor for both gender groups.


Assuntos
Neoplasias da Mama Masculina/patologia , Neoplasias da Mama/patologia , Adulto , Idoso , Neoplasias da Mama/genética , Neoplasias da Mama/mortalidade , Neoplasias da Mama Masculina/genética , Neoplasias da Mama Masculina/mortalidade , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Modelos de Riscos Proporcionais , Receptor ErbB-2/genética , Receptores de Estrogênio/genética , Receptores de Progesterona/genética , Estudos Retrospectivos , Sobrevida
10.
An. psicol ; 38(1): 177-190, ene. 2022. tab, graf
Artigo em Inglês | IBECS | ID: ibc-202879

RESUMO

Gran parte de los estudios sobre Violencia de Género en la Pareja (VGP) presentan a las mujeres como víctimas pasivas, pero en los últimos años el número de investigaciones centradas en fortalezas está aumentando. El objetivo del presente estudio es revisar la literatura empírica sobre resiliencia en mujeres supervivientes de VGP para: (a) analizar el consenso en la definición y evaluación de resiliencia; (b) estudiar los correlatos del constructo; y (c) reflexionar sobre la aplicabilidad de este conocimiento en las políticas y la práctica profesional. Siguiendo las guías PRISMA, se realizó una revisión sistemática en las bases de datos Scopus, WoS y PsycINFO, encontrando 42 artículos publicados en inglés o español sin restricción temporal. Los resultados muestran que los estudios adoptan definiciones de resiliencia tanto orientadas al proceso como al rasgo y a los resultados, y que el método de evaluación difiere entre investigaciones. Entre los correlatos de resiliencia se encontraron factores individuales, relacionales y contextuales. Se necesita un consenso teórico y profundizar en los mecanismos por los cuales los factores de vulnerabilidad o protección afectan a grupos con riesgos específicos. Por último, los gobiernos e instituciones deberían emprender acciones de prevención y de apoyo a las mujeres e hijos/as.(AU)


Most researchonIntimate PartnerViolenceagainstwomen(IPV)hastended topresentwomenaspassivevictims,butinrecentyears,therehasbeenan increaseinstudiesadoptinga strengths-based approach. The aim of the present study is to review the empirical literatureabout re-silience in women survivors of IPV to (a) analyze the consensus on the definition andassessment of resilience; (b) study the correlates of resilience; and (c) reflect on theapplicability of such knowledge in policies and pro-fessional practice. Following PRISMAguidelines, a systematic search was carried out in the Scopus, WoS and PsycINFO databases.The search yield-ed 42 articles published in English or Spanish over an unlimited timeframe.Results showed that process-oriented, trait-oriented, and outcomes-oriented definitions ofresilience were all adopted in the research and that assessment methods also differed acrossstudies.Individual,relational,and contextualfactorswerefoundasresiliencecorrelates.There is a need for a theoretical consensus and for research on the mecha-nisms throughwhich vulnerability or protective factors exert their influ-ence on groups with specific riskconditions.Finally,governmentsand in-stitutionsshouldtakeactionstosupportwomenandchildrenandtopre-ventfutureIPV.(AU)


Assuntos
Humanos , Feminino , Adulto , Ciências da Saúde , Mulheres , Violência de Gênero , Sobrevida , Metodologia , Resiliência Psicológica
11.
Support Care Cancer ; 30(3): 2207-2213, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34704156

RESUMO

PURPOSE: The transitioning of cancer survivors from active treatment to surveillance care has been described as uncoordinated, with lack of communication between healthcare professionals. Survivorship care plans (SCP) are recommended to bridge this transitioning period and help improve coordination of care. SCP contain individualized information about a survivor's cancer diagnosis, treatment, and recommendations for managing treatment-related side effects and improving lifestyle risk factors for cancer recurrence and chronic disease. The aims of the study were to assess the delivery, usefulness, and compliance with SCP of survivors attending a multidisciplinary survivorship clinic and to determine patient suggestions regarding how to improve SCP. METHODS: A total of 110 survivors were interviewed in-person or by phone regarding their SCP following a script with formalized questions. Data were analyzed quantitatively using descriptive statistics. RESULTS: Overall, 65% of participants (72/110) acknowledged having received a SCP and 86% found them useful. Only 11% of survivors (8/72) showed their SCP to other health professionals and about half (33/72) showed it to family/friends. Ninety percent of survivors (65/72) reported following at least one recommendation in their SCP. CONCLUSION: Survivors found SCP helpful but did not share them with other healthcare providers, which questions their usefulness in coordinating care. There were challenges with SCP delivery. Survivors reported they were compliant with SCP lifestyle recommendations. Further research is required to address the utility of SCP to other stakeholders, such as general practitioners, to determine whether they receive the SCP, if they find them helpful, and their expectations regarding SCP.


Assuntos
Sobreviventes de Câncer , Clínicos Gerais , Neoplasias , Humanos , Neoplasias/terapia , Planejamento de Assistência ao Paciente , Sobrevida , Sobreviventes , Sobrevivência
12.
Ann N Y Acad Sci ; 1507(1): 37-48, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-33609316

RESUMO

Extracorporeal cardiopulmonary resuscitation (ECPR) is an emerging method of cardiopulmonary resuscitation to improve outcomes from cardiac arrest. This approach targets patients with out-of-hospital cardiac arrest previously unresponsive and refractory to standard treatment, combining approximately 1 h of standard CPR followed by venoarterial extracorporeal membrane oxygenation (VA-ECMO) and coronary artery revascularization. Despite its relatively new emergence for the treatment of cardiac arrest, the approach is grounded in a vast body of preclinical and clinical data that demonstrate significantly improved survival and neurological outcomes despite unprecedented, prolonged periods of CPR. In this review, we detail the principles behind VA-ECMO-facilitated resuscitation, contemporary clinical approaches with outcomes, and address the emerging new understanding of the process of death and capability for neurological recovery.


Assuntos
Reanimação Cardiopulmonar/mortalidade , Reanimação Cardiopulmonar/métodos , Oxigenação por Membrana Extracorpórea/mortalidade , Oxigenação por Membrana Extracorpórea/métodos , Parada Cardíaca Extra-Hospitalar/mortalidade , Parada Cardíaca Extra-Hospitalar/terapia , Encéfalo/fisiopatologia , Morte , Humanos , Doenças do Sistema Nervoso/mortalidade , Doenças do Sistema Nervoso/fisiopatologia , Doenças do Sistema Nervoso/terapia , Parada Cardíaca Extra-Hospitalar/fisiopatologia , Sobrevida/fisiologia
13.
Acta Psychol (Amst) ; 222: 103459, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34896772

RESUMO

Imagining being stranded in the grasslands of an unknown territory without basic survival materials and subsequently rating the relevance of words for this situation leads to exceptionally good memory for these words. This survival processing effect has received much attention, primarily because it has been argued to disclose the evolutionary foundations of human memory. So far, only fictitious scenarios were used to demonstrate this effect. To provide a fairer test of emotional response against richness-of-encoding explanations of the effect, we aimed at increasing everyday relevance and realism of the survival scenarios. For this purpose, we created two new Covid-19 scenarios, one focusing on emotional response (Covid-19-emotion) and the other on survival strategy (Covid-19-strategy). Both new scenarios were compared to the classical grassland and moving scenarios typically used to investigate the survival processing effect. In Experiment 1, we observed better memory for the grassland and Covid-19-strategy scenarios compared to the other two, but no significant difference between the former. A descriptively similar result pattern emerged in Experiment 2 for the number of ideas generated on how to use objects in the four scenarios. Theoretical implications are discussed.


Assuntos
COVID-19 , Rememoração Mental , Humanos , Memória , SARS-CoV-2 , Sobrevida
14.
Rev. Nutr. (Online) ; 35: e210054, 2022. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1365432

RESUMO

ABSTRACT Objective To assess factors related to the achievement of the caloric estimates of enteral nutritional therapy and the survival of patients with advanced cancer in exclusively palliative care. Methods Retrospective study, where patients using enteral nutrition admitted from March 2019 to February 2020 were divided into two groups: Group 1 included patients who reached 75% of the estimated caloric goals, and Group 2 included those who did not. The data were extracted from the patients' electronic medical records. Logistic regression analyzes were performed to assess associations between the studied sociodemographic, clinical, and nutritional variables, and the Kaplan-Meier curve and Cox regression were used to assess the survival of the groups. Results A total of 158 patients participated in the study, with a median age of 63 (IIQ: 55-70) years. 57% reached the caloric goal (Group 1). In the logistic regression, the functional capacity (OR: 5.82; CI: 2.28-14.84; p<0.001) and symptoms of nausea or vomiting (OR: 0.050; CI: 0.005-0.455; p=0.008) were independent variables for achieving the caloric goal. Cox regression showed Karnofsky Performance Status as an independent predictor for survival (HR: 1.85; CI: 1.13-3.04). Conclusion Patients with better functionality have longer survival and are potential candidates for reaching the caloric goals proposed by national and international guidelines for cancer patients.


RESUMO Objetivo Avaliar os fatores relacionados ao alcance das estimativas calóricas da terapia nutricional enteral e a sobrevida dos pacientes com câncer avançado em cuidados paliativos exclusivos. Métodos Estudo retrospectivo no qual pacientes em uso de nutrição enteral internados no período de março de 2019 a fevereiro de 2020 foram divididos em dois grupos: Grupo 1, composto por pacientes que atingiram 75% das metas calóricas estimadas, e Grupo 2, composto por aqueles que não atingiram. Os dados foram extraídos do prontuário eletrônico dos pacientes. Análises de regressão logística foram realizadas para avaliar associações entre as variáveis sociodemográficas, clínicas e nutricionais estudadas, e a curva de Kaplan-Meier e regressão de Cox foram usadas para avaliar a sobrevida dos grupos. Resultados Participaram do estudo 158 pacientes, com mediana de idade de 63 (IIQ:55-70) anos. Cinquenta e sete por cento dos pacientes atingiram a meta calórica (Grupo 1). Na regressão logística, a capacidade funcional (OR:5,82; IC: 2,28-14,84; p<0,001) e os sintomas náuseas ou vômitos (OR:0,050; IC:0,005-0,455; p=0,008) se mostraram variáveis independentes para o alcance da meta calórica. A regressão de Cox mostrou o Karnofsky Performance Status como preditor independente para sobrevida (HR: 1,85; IC: 1,13-3,04) Conclusão Pacientes com melhor funcionalidade possuem sobrevida maior e são potenciais candidatos ao alcance das metas calóricas propostas por diretrizes nacionais e internacionais para pacientes com câncer em terapia nutricional enteral.


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Nutrição Enteral/efeitos adversos , Neoplasias/terapia , Cuidados Paliativos/métodos , Pacientes/estatística & dados numéricos , Sobrevida , Estudos Retrospectivos
15.
Dis Markers ; 2021: 8223216, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34966465

RESUMO

A lot of evidence has emphasized the function of long noncoding RNAs (lncRNAs) in tumors' development and progression. Nevertheless, there is still a lack of lncRNA biomarkers that can predict the prognosis of acute myeloid leukemia (AML). Our goal was to develop a lncRNA marker with prognostic value for the survival of AML. AML patients' RNA sequencing data as well as clinical characteristics were obtained from the public TARGET database. Then, differentially expressed lncRNAs were identified in female and male AML samples. By adopting univariate and multivariate Cox regression analyses, AML patients' survival was predicted by a seven-lncRNA signature. It was found that 95 abnormal expressed lncRNAs existed in AML. Then, the analysis of multivariate Cox regression showed that, among them, 7 (LINC00461, RP11-309M23.1, AC016735.2, RP11-61I13.3, KIAA0087, RORB-AS1, and AC012354.6) had an obvious prognostic value, and according to their cumulative risk scores, these 7 lncRNA signatures could independently predict the AML patients' overall survival. Overall, the prognosis of AML patients could be predicted by a reliable tool, that is, seven-lncRNA prognostic signature.


Assuntos
Biomarcadores Tumorais/genética , Leucemia Mieloide Aguda/genética , Prognóstico , RNA Longo não Codificante/genética , Sobrevida , Bases de Dados Factuais , Feminino , Humanos , Masculino , Modelos Estatísticos
16.
BMC Health Serv Res ; 21(1): 1353, 2021 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-34922530

RESUMO

PURPOSE: This study presents the validation of an index that defines and measures a patient-centered approach to quality survivorship care. METHODS: We conducted a national survey of 1,278 survivors of breast, prostate, and colorectal cancers to identify their priorities for cancer survivorship care. We identified 42 items that were "very important or absolutely essential" to study participants. We then conducted exploratory and confirmatory factor analyses (EFA/CFA) to develop and validate the Patient-Centered Survivorship Care Index (PC-SCI). RESULTS: A seven-factor structure was identified based on EFA on a randomly split half sample and then validated by CFA based on the other half sample. The seven factors include: (1) information and support in survivorship (7 items), (2) having a medical home (10 items) (3) patient engagement in care (3 items), (4) care coordination (5 items), (5) insurance navigation (3 items), (6) care transitions from oncologist to primary care (3 items), and (7) prevention and wellness services (5 items). All factors have excellent composite reliabilities (Cronbach's alpha 0.84-0.94, Coefficient of Omega: 0.81-0.94). CONCLUSIONS: Providing quality post-treatment care is critical for the long-term health and well-being of survivors. The PC-SCI defines a patient-centered approach to survivorship care to complement clinical practice guidelines. The PC-SCI has acceptable composite reliability, providing the field with a valid instrument of patient-centered survivorship care. The PC-SCI provides cancer centers with a means to guide, measure and monitor the development of their survivorship care to align with patient priorities of care. TRIAL REGISTRATION: ClinicalTrials.gov ID: NCT02362750 , 13 February 2015.


Assuntos
Sobreviventes de Câncer , Neoplasias , Humanos , Neoplasias/terapia , Assistência Centrada no Paciente , Reprodutibilidade dos Testes , Sobrevida , Sobrevivência
17.
Int J Biol Sci ; 17(15): 4442-4458, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34803509

RESUMO

Background: Autophagy regulates many cell functions related to cancer, ranging from cell proliferation and angiogenesis to metabolism. Due to the close relationship between autophagy and tumors, we investigated the predictive value of autophagy-related genes. Methods: Data from patients with hepatocellular carcinoma were obtained from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) databases. A regression analysis of differentially expressed genes was performed. Based on a prognostic model, patients were divided into a high-risk or low-risk group. Kaplan-Meier survival analyses of patients were conducted. The immune landscapes, as determined using single-sample gene set enrichment analysis (ssGSEA), exhibited different patterns in the two groups. The prognostic model was verified using the ICGC database and clinical data from patients collected at Zhongnan Hospital. Based on the results of multivariate Cox regression analysis, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/inosine monophosphate (IMP) cyclohydrolase (ATIC) had the largest hazard ratio, and thus we studied the effect of ATIC on autophagy and tumor progression by performing in vitro and in vivo experiments. Results: Fifty-eight autophagy-related genes were differentially expressed (false discovery rate (FDR)<0.05, log2 fold change (logFC)>1); 23 genes were related to the prognosis of patients. A prognostic model based on 12 genes (ATG10, ATIC, BIRC5, CAPN10, FKBP1A, GAPDH, HDAC1, PRKCD, RHEB, SPNS1, SQSTM1 and TMEM74) was constructed. A significant difference in survival rate was observed between the high-risk group and low-risk group distinguished by the model (P<0.001). The model had good predictive power (area under the curve (AUC)>0.7). Risk-related genes were related to the terms type II IFN response, MHC class I (P<0.001) and HLA (P<0.05). ATIC was confirmed to inhibit autophagy and promote the proliferation, invasion and metastasis of liver cancer cells through the AKT/Forkhead box subgroup O3 (FOXO3) signaling pathway in vitro and in vivo. Conclusions: The prediction model effectively predicts the survival time of patients with liver cancer. The risk score reflects the immune cell features and immune status of patients. ATIC inhibits autophagy and promotes the progression of liver cancer through the AKT/FOXO3 signaling pathway.


Assuntos
Carcinoma Hepatocelular/metabolismo , Cromonas/farmacologia , Proteína Forkhead Box O3/metabolismo , Hidroximetil e Formil Transferases/metabolismo , Neoplasias Hepáticas/metabolismo , Morfolinas/farmacologia , Complexos Multienzimáticos/metabolismo , Nucleotídeo Desaminases/metabolismo , Proteínas Proto-Oncogênicas c-akt/metabolismo , Acetatos/farmacologia , Benzopiranos/farmacologia , Biomarcadores Tumorais , Carcinoma Hepatocelular/genética , Linhagem Celular Tumoral , Sobrevivência Celular , Proteína Forkhead Box O3/genética , Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos , Regulação Neoplásica da Expressão Gênica/fisiologia , Compostos Heterocíclicos com 3 Anéis/farmacologia , Humanos , Hidroximetil e Formil Transferases/genética , Neoplasias Hepáticas/genética , Modelos Biológicos , Complexos Multienzimáticos/genética , Nucleotídeo Desaminases/genética , Proteínas Proto-Oncogênicas c-akt/genética , Sobrevida
18.
Pan Afr Med J ; 40: 13, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34733381

RESUMO

INTRODUCTION: to describe the epidemiological, clinical, therapeutic and evolving characteristics of Behçet´s disease and identify prognostic factors. METHODS: we have realized a retrospective, single-center study, conducted over a period of 26 years and including 130 patients presenting Behçet´s disease and hospitalized in an Internal Medicine Department. RESULTS: the mean age of the Behçet´s disease at onset was 30.3 ±8.8 years and that at diagnosis was 34.6 ±9.4 years. The sex ratio (male/female) was 2.5. The mean delay of diagnosis was 53.5 months. Oral aphthosis was constant. The frequency of the manifestations was: genital aphtosis 71.5%, pseudofolliculitis 84.6%, erythema nodosum 11.5%, positive pathergy test 50%, ocular disease 36.9%, venous thrombosis 30%, arterial disease 4.6%, joint damage 30.8%, neurological disease 19.2% and digestive disease 0.8%. The male gender was significantly associated with ocular involvement (p =0.02), venous disease (p =0.01) and occurrence of relapses (p =0.01). The mean follow up was 68.5 ± 77.3 months. The poor survival prognostic factors were male gender, ocular involvement, venous disease, cardiovascular disease, a duration of follow up ≤12 months and a diagnostic delay ≤ 24 months. Conclusion: improving the prognosis of Behçet´s disease requires a shortening of the time to diagnosis, multidisciplinary collaboration, intensive treatment of functional threats, regular monitoring, and patient adherence.


Assuntos
Síndrome de Behçet/epidemiologia , Hospitalização , Adolescente , Adulto , Idoso , Síndrome de Behçet/diagnóstico , Síndrome de Behçet/fisiopatologia , Diagnóstico Tardio , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Fatores Sexuais , Sobrevida , Tunísia , Adulto Jovem
19.
Taiwan J Obstet Gynecol ; 60(6): 983-994, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34794761

RESUMO

OBJECTIVE: The current research was aimed to identify candidate genes associated with development and progression of epithelial ovarian carcinoma using bioinformatics analysis. MATERIALS AND METHODS: We screened and validated candidate genes associated with carcinogenesis and development of epithelial ovarian carcinoma via bioinformatic analysis in three microarray datasets (GSE14407, GSE29450, and GSE54388) downloaded from the Gene Expression Omnibus (GEO) database. RESULTS: Our bioinformatic analysis identified 514 differentially expressed genes (DEGs) and nine candidate hub genes (CCNB1, CDK1, BUB1, CDC20, CCNA2, BUB1B, AURKA, RRM2, and TTK). Survival analysis using the Kaplan-Meier plotter showed that high expression levels of seven candidate genes (CCNB1, RRM2, BUB1, CCNA2, AURKA, CDK1, and BUB1B) were associated with poor overall survival (OS). Gene Expression Profiling Interactive Analysis (GEPIA) revealed a higher expression level of these seven candidate genes in ovarian carcinoma samples than in normal ovarian samples. Immunostaining results from the Human Protein Atlas (HPA) database suggested that the protein expression levels of CCNB1, CCNA2, AURKA, and CDK1 were increased in ovarian cancer tissues. No difference was observed in RRM2 protein expression level between normal ovarian and ovarian cancer samples. Oncomine analysis revealed an association between the expression patterns of BUB1B, CCNA2, AURKA, CCNB1, CDK1, and BUB1 and patient clinicopathological information. Finally, six genes, namely CCNB1, CCNA2, AURKA, BUB1, BUB1B, and CDK1, were identified as hub genes and a transcription factor (TF)-gene regulatory network was constructed to identify TFs, including POLR2A, ZBTB11, KLF9, and ELF1, that were implicated in regulating these hub genes. CONCLUSION: Six significant hub DEGs associated with a poor prognosis in epithelial ovarian cancer were identified. These could be potential biomarkers for ovarian cancer patients.


Assuntos
Biomarcadores Tumorais/genética , Carcinoma Epitelial do Ovário/genética , Biologia Computacional , Neoplasias Ovarianas/genética , Aurora Quinase A/genética , Feminino , Regulação Neoplásica da Expressão Gênica , Humanos , Estimativa de Kaplan-Meier , Fatores de Transcrição Kruppel-Like , Prognóstico , Sobrevida
20.
PLoS One ; 16(10): e0258986, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34695160

RESUMO

Adaptive memory is the propensity of human memory to easily store and retrieve important information to deal with challenges related to the Pleistocene. Recent evidence shows that humans have had a multiregional evolution across the African continent, including the rainforests and deciduous forests; however, there is little evidence regarding the implications of these origins and the relevant and recurring challenges of these environments on survival processing advantage in memory. In this study, we conducted an experiment with volunteers to analyze whether adaptive memory operates in the retrieval of important information to solve challenges of using medicinal plants to treat diseases in the ancestral environments of the savanna, rainforests, and deciduous forests compared to the modern environments of desert, tundra, coniferous forest, and urban areas. We used simulated survival environments and asked volunteers (30 per simulated scenario) to imagine themselves sick in one of these environments, and needing to find medicinal plants to treat their disease. The volunteers rated the relevance of 32 words to solve this challenge, followed by a surprise memory test. Our results showed no ancestral priority in recalling relevant information, as both ancestral and modern environments showed a similar recall of relevant information. This suggests that the evolved cognitive apparatus allows human beings to survive and can create survival strategies to face challenges imposed in various environments. We believe that this is only possible if the human mind operates through a flexible cognitive mechanism. This flexibility can reflect, for example, the different environments that the first hominids inhabited and the different dangerous situations that they faced.


Assuntos
Adaptação Psicológica , Rememoração Mental , Plantas Medicinais , Sobrevida , Adolescente , Adulto , Evolução Biológica , Cognição , Feminino , Humanos , Masculino , Testes Neuropsicológicos , Adulto Jovem
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