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1.
Pan Afr Med J ; 39: 217, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34630829

RESUMO

Ectopic thyroid tissue in the lateral neck is a rare finding, especially in the submandibular region. This case report presents a 38-year-old female patient with swelling in the lateral cervical neck. Due to a thyroid goitre, right hemithyroidectomy was performed in the past. However, a persistent high thyroglobulin level was detected after surgery. Regarding the suspected tumour in the submental region, a cervical magnetic resonance imaging (MRI) was performed, which revealed a suspicious looking mass. The patient underwent complete surgical excision and the histopathological report concluded that the tumour was ectopic thyroid tissue. Her thyroglobulin level decreased back to a normal level after excision of the submandibular mass. These results show that ectopic thyroid tissue must be considered a differential diagnosis for patients with unclear swelling in the submental region.


Assuntos
Glândula Submandibular/diagnóstico por imagem , Tireoglobulina/sangue , Disgenesia da Tireoide/diagnóstico , Adulto , Diagnóstico Diferencial , Feminino , Bócio/cirurgia , Humanos , Imageamento por Ressonância Magnética , Glândula Submandibular/patologia , Disgenesia da Tireoide/cirurgia , Tireoidectomia/métodos
2.
J Assoc Physicians India ; 69(7): 11-12, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34431276

RESUMO

Presence of ectopic thyroid tissue in unusual locations is a rare phenomenon. Herein we present the case of a 55 year old lady, who on evaluation of dyspnoea was detected to have a mediastinal mass. Initial radiological evaluation showed the presence of a mass arising from the wall of the oesophagus which was presumed most likely to be leiomyosarcoma. She underwent surgical resection of the mass, but on histopathological examination, it turned out to be a nodular goiter which was lying within the smooth muscle layer of the oesophageal wall.


Assuntos
Doenças do Mediastino , Disgenesia da Tireoide , Esôfago/diagnóstico por imagem , Feminino , Humanos , Mediastino/diagnóstico por imagem , Pessoa de Meia-Idade , Radiografia , Disgenesia da Tireoide/diagnóstico por imagem
3.
BMC Ophthalmol ; 21(1): 314, 2021 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-34454461

RESUMO

BACKGROUND: Ectopic thyroid tissue in the iris, also known as a thyroid glandular epithelial choristoma of the iris, has only been described twice in the literature. In both cases it remained asymptomatic. CASE PRESENTATION: A 67-year-old female patient presented for the first time in mid-2017 with corneal endothelial decompensation, with a history of complicated cataract surgery and IStent® implantation. Slit lamp microscopy showed endothelial decompensation, pseudophakia, anterior synechiae and a whitish iris tumour adhering to the endothelium. The latter had existed since childhood. Given these findings, reduced visual acuity of hand movement perception and an intraocular pressure of 23 mmHg, we performed a keratoplasty combined with an en bloc resection of the iris tumour at 9 o'clock and sector iridectomy at the end of 2019. Histological and immunohistological examination of the iris tumour unexpectedly revealed thyroid tissue. After the procedure described above, the patient had an increase in visual acuity while the graft stayed clear and the eye showed no evidence of tumour recurrence or other complications. CONCLUSIONS: We report a third case of ectopic thyroid tissue in the iris. Both previous cases remained asymptomatic, whereas in our case, size and location of the ectopic thyroid tissue contributed to a more complex cataract surgery resulting in endothelial decompensation. Therefore, in such cases appropriate patient information should be provided prior to cataract surgery. Furthermore, careful histological examination and examination of the thyroid is important to exclude malignant diagnoses such as a metastasis of a follicular thyroid carcinoma.


Assuntos
Neoplasias da Íris , Disgenesia da Tireoide , Idoso , Criança , Feminino , Humanos , Iridectomia , Iris/cirurgia , Neoplasias da Íris/diagnóstico , Neoplasias da Íris/cirurgia , Recidiva Local de Neoplasia
4.
Afr J Paediatr Surg ; 18(4): 231-234, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34341309

RESUMO

Thyroglossal duct cyst is the most common cause of anterior midline neck swelling in children, but ectopic thyroid is an important but rare differential diagnosis. Establishing the orthotopic thyroid gland status is crucial as inadvertent removal of a lone functioning ectopic thyroid tissue in young children could lead to fluttering of growth and development if not identified early. We report the case of a 2 years 10-month-old boy who had Sistrunk's procedure for 'thyroglossal duct cyst': Diagnosed using USS, defaulted follow-up and presented subsequently with growth retardation from hypothyroidism.


Assuntos
Hipotireoidismo , Cisto Tireoglosso , Disgenesia da Tireoide , Criança , Pré-Escolar , Diagnóstico Diferencial , Humanos , Hipotireoidismo/diagnóstico , Hipotireoidismo/etiologia , Lactente , Masculino , Cisto Tireoglosso/cirurgia , Disgenesia da Tireoide/diagnóstico por imagem , Disgenesia da Tireoide/cirurgia
5.
BMJ Case Rep ; 14(7)2021 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-34315743

RESUMO

We report a case of a 46-year-old woman who presented with a midline neck mass 2 years after total thyroidectomy for Graves' disease. Despite levothyroxine treatment withdrawal, she remained biochemically with subclinical hyperthyroidism. Her thyroid stimulating hormone receptor antibodies were consistently elevated. Neck ultrasonography revealed an infrahyoid solid nodule and pertechnetate scintigraphy confirmed an increased uptake at the same level, without any uptake in the thyroid bed. Treatment with methimazole 5 mg/day was initiated with clinical improvement and achievement of euthyroidism. After that, she received 10 mCi of radioactive iodine. Since then, she experienced regression of the neck mass and is doing well on a replacement dose of levothyroxine. Recurrence of Graves' disease in ectopic thyroid following total thyroidectomy is extremely rare. This diagnose should be considered in patients who underwent total thyroidectomy and remained with thyrotoxicosis despite decreasing the levothyroxine dose.


Assuntos
Doença de Graves , Disgenesia da Tireoide , Neoplasias da Glândula Tireoide , Feminino , Doença de Graves/cirurgia , Humanos , Radioisótopos do Iodo , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Disgenesia da Tireoide/diagnóstico por imagem , Disgenesia da Tireoide/cirurgia , Tireoidectomia
6.
Med J Malaysia ; 76(4): 600-602, 2021 07.
Artigo em Inglês | MEDLINE | ID: mdl-34305130

RESUMO

The thyroid gland and its hormones play important roles in organ development and in the homeostatic control of physiological mechanisms in human beings. As a result of embryogenic descent of thyroid gland, it commonly resides along the midline - from tongue to mediastinum (90%). Ectopic thyroid gland is a rare occurrence, with extra-lingual ectopic thyroid gland being even rarer. Thus, there is a concern for malignant metastasis. Madam H, a 56-year-old healthy woman presented to the Hospital Sultanah Nora Ismail, Johor, Malaysia in April 2020 with an increasing size of right axilla mass and history of weight loss. She was having right axilla mass for the previous 7 years but only noticed the increase in size about 1 year ago. She has no other constitutional symptoms. A tru-cut biopsy performed demonstrated a benign ectopic thyroid tissue. Thyroid function test showed primary hypothyroidism. Serum Chromogranin A and other thyroid antibodies were within the normal value. Further radiological imaging showed the normal thyroid gland at neck, with no signs of distant malignancy. There was no other axillary, mediastinal or hilar lymph node enlargement. She was started on regular T. L Thyroxine 100mcg daily and given regular follow-up in endocrine clinic. Benign ectopic thyroid gland is an unusual finding. As such, follow up is needed with possibility of carcinomatous transformation such as papillary carcinoma should be considered.


Assuntos
Carcinoma Papilar , Disgenesia da Tireoide , Neoplasias da Glândula Tireoide , Axila , Feminino , Humanos , Pessoa de Meia-Idade , Disgenesia da Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/diagnóstico , Neoplasias da Glândula Tireoide/cirurgia
7.
Med Arch ; 75(2): 154-157, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34219877

RESUMO

Background: Ectopic thyroid papillary carcinoma presenting as bilateral neck lymph nodes metastasis is very rare. Ectopic thyroid tissue may appear in any location along the trajectory of the thyroglossal duct from the foramen cecum to the mediastinum. It is subject to malignant transformation and is classically accompanied by a similar transformation of the native thyroid gland. Similar to that of the native thyroid gland, the most common malignancy found is Papillary thyroid carcinoma. Unusual cases in which ectopic thyroid carcinoma presents with normal native tissue support an alternative hypothesis that ectopic thyroid tissue may develop malignancies independently from the native thyroid gland. Objective: We present an extremely rare case of a 30-year-old woman previously diagnosed with Hashimoto's thyroiditis, presenting with a palpable mass in the lateral neck suspicious for malignancy. Results: After several examinations and surgical removal of the mass, histopathologic evaluation of the continuous sections of the thyroid, demonstrated metastatic disease from papillary carcinoma of the thyroid. Total thyroidectomy and biopsy revealed benign thyroid tissue without any foci of microcarcinoma. A hypothesis of ectopic thyroid tissue and its malignant transformation was made. Conclusion: By presenting this case, our goal is to highlight and make the physicians aware of the possibility of developing primary carcinoma of the ectopic thyroid tissue, without an active tumor of the thyroid gland.


Assuntos
Carcinoma Papilar/complicações , Carcinoma Papilar/fisiopatologia , Carcinoma Papilar/cirurgia , Metástase Neoplásica/fisiopatologia , Câncer Papilífero da Tireoide/fisiopatologia , Câncer Papilífero da Tireoide/cirurgia , Disgenesia da Tireoide/fisiopatologia , Adulto , Feminino , Humanos , Disgenesia da Tireoide/cirurgia , Resultado do Tratamento
8.
Genet Med ; 23(10): 1944-1951, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34194003

RESUMO

PURPOSE: Congenital hypothyroidism (CH) is a common congenital endocrine disorder in humans. CH-related diseases such as athyreosis, thyroid ectopy, and hypoplasia are primarily caused by dysgenic thyroid development. However, the underlying molecular mechanisms remain unknown. METHODS: To identify novel CH candidate genes, 192 CH patients were enrolled, and target sequencing of 21 known CH-related genes was performed. The remaining 98 CH patients carrying no known genes were subjected to exome sequencing (ES). The functions of the identified variants were confirmed using thyroid epithelial cells in vitro and in zebrafish model organisms in vivo. RESULTS: Four pathogenic GBP1 variations from three patients were identified. In zebrafish embryos, gbp1 knockdown caused defective thyroid primordium morphogenesis and hypothyroidism. The thyroid cells were stuck together and failed to dissociate from each other to form individual follicles in gbp1-deficient embryos. Furthermore, defects were restored with wild-type human GBP1 (hGBP1) messenger RNA (mRNA) except for mutated hGBP1 (p.H150Y, p.L187P) overexpression. GBP1 promoted ß-catenin translocation into the cytosol and suppressed the formation of cellular adhesion complexes. Suppression of cell-cell adhesion restored the thyroid primordium growth defect observed in gbp1-deficient zebrafish embryos. CONCLUSION: This study provides further understanding regarding thyroid development and shows that defective cellular remodeling could cause congenital hypothyroidism.


Assuntos
Hipotireoidismo Congênito , Proteínas de Ligação ao GTP , Disgenesia da Tireoide , Glândula Tireoide/crescimento & desenvolvimento , Animais , Hipotireoidismo Congênito/genética , Modelos Animais de Doenças , Proteínas de Ligação ao GTP/genética , Humanos , Morfogênese , Mutação , Regulação para Cima , Peixe-Zebra/genética
9.
BMC Cancer ; 21(1): 718, 2021 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-34147083

RESUMO

BACKGROUND: Liver metastasis is the most common cause of death in patients with colorectal cancer (CRC). Phosphatase of regenerating liver-3 induces CRC metastasis by epithelial-to-mesenchymal transition, which promotes CRC cell liver metastasis. Mesenchymal-to-epithelial transition (MET), the opposite of epithelial-to-mesenchymal transition, has been proposed as a mechanism for the establishment of metastatic neoplasms. However, the molecular mechanism of MET remains unclear. METHODS: Using Immunohistochemistry, western blotting, invasion assays, real-time quantitative PCR, chromatin immunoprecipitation, luciferase reporter assays, human miRNA arrays, and xenograft mouse model, we determined the role of hepatocyte exosome-derived miR-203a-3p in CRC MET. RESULTS: In our study, we found that miR-203a-3p derived from hepatocyte exosomes increased colorectal cancer cells E-cadherin expression, inhibited Src expression, and reduced activity. In this way miR-203a-3p induced the decreased invasion rate of CRC cells. COCLUSION: MiR-203a-3p derived from hepatocyte exosomes plays an important role of CRC cells to colonize in liver.


Assuntos
Neoplasias Colorretais/genética , Exossomos/genética , MicroRNAs/genética , Animais , Proliferação de Células , Neoplasias Colorretais/patologia , Hipotireoidismo Congênito , Modelos Animais de Doenças , Transição Epitelial-Mesenquimal , Humanos , Camundongos , Camundongos Nus , Disgenesia da Tireoide
10.
BMJ Case Rep ; 14(5)2021 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-33975840

RESUMO

Lateral aberrant ectopic thyroid is very rare, comprising only 1%-3% of all the ectopic thyroid tissue. Clinically, these lesions are mistaken for lymph node swelling or metastatic tumour. Primary carcinoma in lateral aberrant ectopic thyroid with normal active native thyroid is very uncommon. We report a case of papillary carcinoma in lateral aberrant ectopic thyroid tissue, with a completely normal native thyroid gland in a 53-year-old man, who presented with a massive swelling in the lateral aspect of the neck clinically and radiologically diagnosed as a malignant soft tissue tumour with differential diagnosis of malignant lymphoma. Fine needle aspiration cytology revealed metastatic papillary carcinoma. In toto excision of the soft tissue mass along with subtotal thyroidectomy was performed. Histology of the mass revealed papillary carcinoma of lateral aberrant ectopic thyroid, while the thyroid gland did not show evidence of malignancy. The postsurgical period was uneventful, and the patient underwent radioiodine ablation.


Assuntos
Carcinoma Papilar , Disgenesia da Tireoide , Neoplasias da Glândula Tireoide , Carcinoma Papilar/diagnóstico por imagem , Carcinoma Papilar/cirurgia , Humanos , Radioisótopos do Iodo , Masculino , Pessoa de Meia-Idade , Disgenesia da Tireoide/diagnóstico por imagem , Disgenesia da Tireoide/cirurgia , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/cirurgia , Tireoidectomia
11.
Neuroradiology ; 63(10): 1739-1742, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34032885

RESUMO

Ectopic thyroid tissue is a rare entity, resulting from developmental abnormality during the migration of the embryonic thyroid germ from the floor of the primitive foregut to its final pre-tracheal position. Although ectopic thyroid tissue may be located anywhere, its location at the skull base is extremely rare. We report a case of ectopic thyroid tissue at the skull base in a 19-year-old man with multimodality imaging findings.


Assuntos
Disgenesia da Tireoide , Adulto , Humanos , Base do Crânio/diagnóstico por imagem , Disgenesia da Tireoide/diagnóstico por imagem , Adulto Jovem
14.
Endocrine ; 71(3): 696-705, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33650047

RESUMO

INTRODUCTION: Congenital hypothyroidism (CH) is the most frequent neonatal endocrine disorder and one of the most common preventable forms of mental retardation worldwide. CH is due to thyroid development or thyroid function defects (primary) or may be of hypothalamic-pituitary origin (central). Primary CH is caused essentially by abnormal thyroid gland morphogenesis (thyroid dysgenesis, TD) or defective thyroid hormone synthesis (dyshormonogenesis, DH). TD accounts for about 65% of CH, however a genetic cause is identified in less than 5% of patients. PURPOSE: The pathogenesis of CH is largely unknown and may include the contribution of individual and environmental factors. During the last years, detailed phenotypic description of patients, next-generation sequence technologies and use of animal models allowed the discovery of novel candidate genes in thyroid development, function and pathways. RESULTS AND CONCLUSION: We provide an overview of recent genetic causes of primary and central CH. In addition, mode of inheritance and the oligogenic model of CH are discussed.


Assuntos
Hipotireoidismo Congênito , Disgenesia da Tireoide , Hipotireoidismo Congênito/genética , Bases de Dados Genéticas , Humanos , Recém-Nascido , Mutação , Disgenesia da Tireoide/genética , Hormônios Tireóideos
15.
BMJ Case Rep ; 14(2)2021 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-33637500

RESUMO

Ectopic thyroid tissue (ETT) is a rare developmental abnormality due to aberrant embryogenesis of the thyroid gland. Although rare (<1%), papillary thyroid carcinoma (PTC) is the most common malignant transformation seen. A 34-year-old man presented with neck nodal swelling, on preoperative evaluation, was found to have PT) in ETT with the normal thyroid gland and nodal metastasis. The patient underwent surgery for PTC along with Sistrunk's procedure and the histopathology revealed ectopic thyroid carcinoma with a normal thyroid and lymph nodal metastasis. Although a rare entity, the possibility of an ectopic thyroid carcinoma should be considered in differentiated cancers with neck nodes in the setting of a normal thyroid gland. Clinical suspicion and radiological imaging would help improve the preoperative diagnosis which in turn alters the management and thereby providing a better outcome to the patient.


Assuntos
Carcinoma Papilar , Disgenesia da Tireoide , Neoplasias da Glândula Tireoide , Adulto , Carcinoma Papilar/diagnóstico por imagem , Carcinoma Papilar/cirurgia , Humanos , Masculino , Câncer Papilífero da Tireoide/cirurgia , Disgenesia da Tireoide/diagnóstico por imagem , Disgenesia da Tireoide/cirurgia , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/cirurgia , Tireoidectomia
16.
Echocardiography ; 38(3): 500-503, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33594689

RESUMO

Intracardiac ectopic thyroid tissue is an extremely rare condition, with only 37 cases reported in the English literature. We present a case of intracardiac ectopic thyroid adenoma and briefly review the published reports.


Assuntos
Coristoma , Disgenesia da Tireoide , Coristoma/diagnóstico por imagem , Coração , Humanos , Doenças Raras , Disgenesia da Tireoide/diagnóstico por imagem
17.
Medicine (Baltimore) ; 100(2): e24042, 2021 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-33466154

RESUMO

RATIONALE: The prevalence of ectopic thyroid is extremely low, with the condition observed in approximately 1 in 100,000 to 300,000 people. Thyroid gland ectopia develops as a result of the presence of developmental abnormalities during the migration of the thyroid anlage from the floor of the primitive foregut to its final position in the neck. Ectopic thyroid tissue is commonly observed in the lingual region, but can also present in other head and neck regions, as well as regions located at a large distance from the neck. PATIENT CONCERNS: A 67-year-old woman who had experienced left lumbago and leg pain was transferred to our hospital following the worsening of her lumbago-related symptoms in the 2 months preceding her presentation. Seven years ago, the patient had recurrent lumbago and leg pain without obvious inducement, and visited a local clinic for treatment. The severity of her symptoms fluctuated; their intensity increased after participation in activities and decreased after rest. DIAGNOSES: The patient was diagnosed as having an ectopic thyroid gland that was located on the L4 vertebral body. INTERVENTIONS: The patient chose to undergo surgery, with supportive care, following tumor discovery. OUTCOMES: After surgical treatment, the degree of lumbar spinal stenosis improved, and the patient's clinical symptoms were alleviated. LESSONS: Clinically, ectopic goiter is diagnosed through radionuclide thyroid imaging, ultrasound examination, computed tomography, magnetic resonance imaging, and biopsy pathology. However, the imaging manifestations in this case were atypical, leading to greater diagnostic difficulties. A conclusion was finally reached based on pathology.


Assuntos
Dor Lombar/etiologia , Vértebras Lombares/patologia , Disgenesia da Tireoide/complicações , Idoso , Feminino , Humanos , Vértebras Lombares/cirurgia , Disgenesia da Tireoide/cirurgia
18.
Medicine (Baltimore) ; 100(2): e24237, 2021 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-33466206

RESUMO

RATIONALE: Mutations of the v-Raf murine sarcoma viral oncogene homolog B (BRAF) oncogene and telomerase reverse transcriptase (TERT) promoter region are indicators of poor prognosis in papillary thyroid carcinoma (PTC) and might predict future occurrences of distant metastases. However, the clinical significance of these genetic aberrancies in PTCs arising in ectopic locations is not well established. PATIENT CONCERNS: We describe a patient with a previous history of radioiodine (RAI)-treated hyperthyroidism and a surgically resected right-sided follicular thyroid adenoma. In 2013, a 6 mm follicular variant papillary thyroid carcinoma was diagnosed following a left-sided thyroid lobectomy. The central compartment displayed 9 tumor-free lymph nodes, and no adjuvant treatment was planned. DIAGNOSES: Three years later, a 26 mm pre-tracheal relapse was noted, however, the excised lesion was consistent with a tall cell variant of papillary thyroid carcinoma (TCV-PTC) arising in ectopic thyroid tissue. RAI treatment was commenced. Four years later, a 5 mm subcutaneous lesion in the anterior neck was surgically removed and diagnosed as metastatic TCV-PTC with a codon 600 BRAF mutation and a C228T TERT promoter mutation. INTERVENTIONS: RAI treatment was re-initiated. Molecular re-examination of the primary follicular variant papillary thyroid carcinoma demonstrated a codon 600 BRAF mutation and a TERT promoter wildtype sequence, while the primary TCV-PTC was positive for mutations in both codon 600 of BRAF as well as the TERT promoter. OUTCOMES: The patient is alive and well without signs of relapse 7 months after the latest round of RAI. LESSONS: We conclude that the occurrence of combined BRAF and TERT promoter mutations in the primary lesion from 2016 was associated to the manifestation of distant metastases 4 years later, strengthening the benefit of mutational screening of these genes in clinical routine for thyroid carcinomas arising in aberrant locations.


Assuntos
Proteínas Proto-Oncogênicas B-raf/genética , Telomerase/genética , Câncer Papilífero da Tireoide/genética , Disgenesia da Tireoide/genética , Neoplasias da Glândula Tireoide/genética , Idoso , Feminino , Humanos , Mutação , Regiões Promotoras Genéticas
19.
J Small Anim Pract ; 62(2): 137-144, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-33150621

RESUMO

OBJECTIVES: This study aimed to describe the clinical and diagnostic characteristics, as well as outcomes of radioiodine treatment in dogs with hyperthyroidism caused by a non-resectable ectopic thyroid tumour. MATERIALS AND METHODS: This retrospective study reviewed the medical records between 2008 and 2018 of dogs diagnosed with hyperthyroidism secondary to a non-resectable ectopic thyroid tumour and treated with radioiodine. RESULTS: Five dogs were included in the study. Three dogs had sublingual ectopic tumours, of which one also had a unilateral cervical thyroid tumour. The remaining two dogs were diagnosed with an ectopic thyroid tumour at the level of the caudal pharynx and the heart base, respectively. All cases were treated with radioiodine. The size of the ectopic masses decreased after radioiodine treatment. Total thyroxine concentrations returned to reference ranges in all dogs. Further, clinical signs of hyperthyroidism disappeared after treatment in all patients. One dog developed myelosuppression secondary to radioiodine treatment. The dog with metastasis had a very short survival compared to the four dogs without metastasis (3 months compared to 7, 36, 50 and 24 months, respectively) and succumbed most likely to thyroid-related problems. In the remaining four dogs, their quality of life improved. They died due to diseases unrelated to the ectopic thyroid tumour. CLINICAL SIGNIFICANCE: Radioiodine therapy should be considered as a treatment option in dogs diagnosed with hyperthyroidism due to a non-resectable ectopic thyroid tumour.


Assuntos
Doenças do Cão , Hipertireoidismo , Disgenesia da Tireoide , Neoplasias da Glândula Tireoide , Animais , Doenças do Cão/etiologia , Doenças do Cão/radioterapia , Cães , Hipertireoidismo/radioterapia , Hipertireoidismo/veterinária , Radioisótopos do Iodo/uso terapêutico , Qualidade de Vida , Estudos Retrospectivos , Disgenesia da Tireoide/veterinária , Neoplasias da Glândula Tireoide/radioterapia , Neoplasias da Glândula Tireoide/veterinária
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