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1.
Work ; 67(4): 763-765, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33325426

RESUMO

BACKGROUND: During the coronavirus disease (COVID-19) pandemic, people volunteered for sewing hand-made face masks. However, sewing-machine operating might be associated with high ergonomic risk and a negative impact on musculoskeletal health. OBJECTIVE AND METHODS: This paper describes an ultrasonographic diagnosis of a foot ganglion - after sewing 300 face masks within two months using a foot-operated sewing machine. RESULTS: The patient significantly improved after an ultrasound-guided aspiration and corticosteroid injection. CONCLUSION: In short, we highlight the importance of ultrasound examination in the management of work (overuse)-related disorders in occupational medicine practice.


Assuntos
COVID-19 , Doenças do Pé/diagnóstico por imagem , Cistos Glanglionares/diagnóstico por imagem , Doenças Profissionais/diagnóstico por imagem , Indústria Têxtil , Voluntários , Anestésicos Locais/administração & dosagem , Anti-Inflamatórios/administração & dosagem , COVID-19/epidemiologia , COVID-19/prevenção & controle , Transtornos Traumáticos Cumulativos/complicações , Drenagem/métodos , Feminino , Doenças do Pé/etiologia , Traumatismos do Pé/complicações , Cistos Glanglionares/etiologia , Humanos , Máscaras , Acetato de Metilprednisolona/administração & dosagem , Pessoa de Meia-Idade , Doenças Profissionais/etiologia , Pandemias , SARS-CoV-2 , Trimecaína/administração & dosagem , Ultrassonografia de Intervenção
2.
Biomed Res Int ; 2020: 7636290, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32420370

RESUMO

A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimulating activity, exceeding the activity of the methyluracil as a comparison drug. Compounds BIV-117 and BIV-119 had erythropoiesis- and thrombocytopoiesis-stimulating activity at the level of methyluracil.


Assuntos
Leucopoese/efeitos dos fármacos , Trimecaína/farmacologia , Animais , Doxorrubicina/efeitos adversos , Doxorrubicina/farmacologia , Eritropoese/efeitos dos fármacos , Feminino , Ratos , Trombopoese/efeitos dos fármacos
3.
Physiol Res ; 68(Suppl 1): S65-S74, 2019 11 22.
Artigo em Inglês | MEDLINE | ID: mdl-31755292

RESUMO

Low back pain (LBP) represents an important subgroup of vertebrogenic pain with estimated prevalence around 80 %. Locally acting injectable collagen for topical application has recently extended the limited range of treatment options. The aim of the study was to evaluate the efficacy and safety of injectable collagen in patients with LBP. Patients suffering from LBP (< three months) were enrolled. They were administered either collagen 4 ml or trimecaine 1 % 4 ml in the form of subcutaneous paravertebral injections into eight pre-specified points (0.5 ml per each point) in the following schedule: two administrations in the first and second week, one in the third week. The pain intensity, Thomayer distance, Oswestry disability index, Lasseque test, quality of life, consumption of rescue medication and safety were evaluated. Exertional and rest pain, evaluated by a visual analogue scale, gradually decreased in both groups. Both treatments showed a statistically significant improvement in mobility and quality of life. The consumption of paracetamol as a rescue medication was significantly lower in patients treated with collagen than in the group treated with trimecaine (p=0.048). The analgesic efficacy of locally acting injectable collagen, as well as an analgesic sparing effect when compared to local anesthetics were demonstrated.


Assuntos
Dor Aguda/tratamento farmacológico , Colágeno/administração & dosagem , Dor Lombar/tratamento farmacológico , Trimecaína/administração & dosagem , Adulto , Idoso , Analgésicos/administração & dosagem , Feminino , Hamamelis , Humanos , Masculino , Pessoa de Meia-Idade , Extratos Vegetais/administração & dosagem , Raízes de Plantas/química , Estudos Prospectivos , Método Simples-Cego , Resultado do Tratamento
4.
Acta Chir Orthop Traumatol Cech ; 78(4): 339-42, 2011.
Artigo em Tcheco | MEDLINE | ID: mdl-21888845

RESUMO

PURPOSE OF THE STUDY: Both the range of motion and load transfer of the sacroiliac (SI) joint improve considerably after lumbar spine surgery. When, following surgery, SI joint pain develops in spite of appropriate physical therapy, injection of an anaesthetic with added corticosteroid into the SI joint is a first choice treatment. The aim of this presentation is to provide information on our experience with this therapy. MATERIAL AND METHODS: Thirty-four patients after lumbar spine fusion reported lumbalgia different form pain before surgery. In 14 (41%) of them, pain in one of the SI joints was diagnosed as the cause. This group included 12 women and two men at an average age of 56 (range, 47 to 68) years. Ten patients underwent lumbosacral fixation and four had segmental ("floating") lumbar spine fusion. All patients experienced lumbalgia at more than 3 months following surgery, at 8 months on the average (range, 4 to 12 months). None of them had SI joint pain before surgery. The diagnosis was based on specific manoeuvres on physical examination of the joint. Each patient was given an injection of 20 mg (0.5 ml) Methylprednisolone (Depo-Medrol®, Pfizer, Puurs, Belgium) and 4.5 ml 1% Mesocain (Zentiva, Praha, CR).They were inquired as to pain relief 24 h later and then at 1, 3 and 6 months after injection. Subjective feelings were assessed by a visual analogue scale (VAS). The results were analysed using descriptive statistics. RESULTS: All patients reported pain relief within 24 h of injection, but not its complete resolution. The average VAS score before and after the blockage of the SI joint was 9.1 points (8-10) and 4.8 points (2-7), respectively; this implies improvement by an average of 4.3 points (1-6), i.e., approximately by 47.3% (12.5-62.5). The duration of effects varied greatly from patient to patient. The average interval between injection and pain recurrence lasted for 5 weeks (1-28). Most frequently, relief was experienced for 2 weeks, or for 6.8 weeks with the standard deviation included. DISCUSSION Sacroiliac joint dysfunction is a very frequent cause of lumbalgia, particularly after lumbar spine surgery. Physical therapy may not always be effective. SI joint arthrodesis is indicated only in rare cases. One of the few possibilities of pain relief involves intra-articular injection of an anaesthetic with corticosteroid for booster effect. The treatment of SI joint blockage after spinal fusion has recently been dealt with in three reports in the international literature; their conclusions are in accordance with the results of this study. CONCLUSIONS: Lumbar spine stabilisation surgery may result in overloading the SI joints as the "adjacent segments". An intra-articular injection of anaesthetic can be considered a reliable method for ascertaining the SI joint as the source of a patient's problems. However, even with corticosteroid added, pain relief is not usually long-lasting.


Assuntos
Anestésicos Locais/administração & dosagem , Dor Lombar/terapia , Vértebras Lombares/cirurgia , Metilprednisolona/análogos & derivados , Fusão Vertebral , Trimecaína/administração & dosagem , Idoso , Feminino , Humanos , Injeções Intra-Articulares , Masculino , Metilprednisolona/administração & dosagem , Acetato de Metilprednisolona , Pessoa de Meia-Idade , Medição da Dor , Articulação Sacroilíaca
5.
Eur Arch Otorhinolaryngol ; 268(7): 1009-11, 2011 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-21328004

RESUMO

This paper presents two cases of using erroneous concentrations of epinephrine during endonasal surgery. The two patients discussed were part of a larger study aimed at monitoring the absorption of epinephrine upon injection into the nasal mucosa. During this study, we observed major cardiovascular reactions in two consecutive patients--ventricular tachycardia with ventricular extrasystole and a significant rise in systolic and diastolic blood pressure and pulse rate. This state required pharmacological intervention. In hindsight, it was found that an erroneous application of ten times higher (1:10,000) concentration of epinephrine than the usual was injected. The applied solution was prepared in our institutional pharmacy and was labelled incorrectly (1:100,000 instead of 1:10,000). The authors have analysed the steps leading to the erroneous applications and recommend safety precautions for the prevention of errors in the concentration levels of epinephrine. Epinephrine injections in concentrations of 1:10,000, followed by analyses of epinephrine levels in venous blood, have not yet been described in available literature.


Assuntos
Arritmias Cardíacas/induzido quimicamente , Epinefrina/efeitos adversos , Erros de Medicação/efeitos adversos , Nariz/cirurgia , Vasoconstritores/efeitos adversos , Adulto , Anestésicos Locais/administração & dosagem , Relação Dose-Resposta a Droga , Epinefrina/administração & dosagem , Humanos , Injeções , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Trimecaína/administração & dosagem , Vasoconstritores/administração & dosagem
6.
J Physiol Pharmacol ; 60(2): 89-93, 2009 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-19617651

RESUMO

In the present study we investigated the possibility of central convergence of neural pathways coming from distant anatomical regions in modulating the cough response. We addressed this issue by inducing cough from the tracheo-bronchial region on the background of capsaicin-stimulated and mesocain-blocked nasal mucosa in 14 anesthetized guinea pigs. The control group consisted of 6 guinea pigs in which the active agents, capsaicin and mesocain, were substituted for by inert physiological saline. All animals were tracheostomized, and the larynx was disconnected from the proximal part of the trachea with preserved innervations, and all were subjected to the same protocol. Cough, induced by mechanical irritation of the tracheo-bronchial mucosa, was elicited three times: in the control condition, after intranasal capsaicin challenge, and after another capsaicin challenge preceded by intranasal instillation of a local anesthetic, mesocain. The main finding of the study was that the number of cough efforts per bout, assessed from positive deflections on the intrapleural pressure recordings, was significantly enhanced by intranasal capsaicin challenge and this effect was reversed by intranasal pretreatment with the anesthetic mesocain [2.1 +/-0.2 (control) vs. 3.5 +/-0.4 (capsaicin) vs. 2.2 +/-0.2 (capsaicin after mesocain) (P<0.01)], with no appreciable changes in the magnitude of cough efforts. The cough response in the control group remained unchanged. We conclude that tracheo-bronchial cough may be modified by neural sensory input to the brain coming from nasal mucosa. Therefore, cough reflex is subject to central convergence of peripheral neural pathways originating at distant anatomical locations.


Assuntos
Tosse/fisiopatologia , Mucosa Nasal/efeitos dos fármacos , Vias Neurais/efeitos dos fármacos , Traqueia/efeitos dos fármacos , Administração Intranasal , Anestésicos Locais/farmacologia , Animais , Capsaicina/farmacologia , Tosse/etiologia , Cobaias , Masculino , Mucosa Nasal/inervação , Vias Neurais/fisiopatologia , Neurônios Aferentes/efeitos dos fármacos , Neurônios Aferentes/fisiologia , Estimulação Física , Reflexo/efeitos dos fármacos , Traqueia/inervação , Trimecaína/farmacologia
7.
Pediatr Cardiol ; 30(2): 194-6, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-18709401

RESUMO

This report describes a fetus presenting with second-degree atrioventricular block, sinus bradycardia, and transient ventricular tachycardia with ventriculoatrial dissociation. Long QT syndrome (LQTS) was suspected due to the association of heart rhythm disturbances and very short transmitral early deceleration time. This impaired relaxation of the left ventricle was explained by the extreme prolongation of the refractory period caused by the prolonged relaxation time. The infant was treated successfully with beta-blockers and implantation of a pacemaker. The prognosis is poor when LQTS presents utero or during the first week of life. To date, only a few case reports of a fetus with LQTS have been published.


Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Estimulação Cardíaca Artificial , Síndrome do QT Longo/diagnóstico , Diagnóstico Pré-Natal , Adulto , Antiarrítmicos/uso terapêutico , Feminino , Doenças Fetais/diagnóstico , Doenças Fetais/tratamento farmacológico , Doenças Fetais/terapia , Humanos , Síndrome do QT Longo/tratamento farmacológico , Síndrome do QT Longo/terapia , Masculino , Metipranolol/uso terapêutico , Gravidez , Trimecaína/uso terapêutico
8.
Bratisl Lek Listy ; 109(3): 111-5, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18517133

RESUMO

OBJECTIVES: To compare the analgesic potency and side effects of epidural combination trimecaine with morphine and bupivacaine with fentanyl in postoperative analgesia after a major urological surgery. METHODS: We randomised 150 consecutive patients. In the trimecain/morphine group (n = 75) trimecaine 50 mg with 4 mg morphine was given epidurally in 8 hour intervals. In the bupivacain/fentanyl group (n = 75) the infusion of 0.25 % bupivacaine and fentanyl 2 microg/ml was administered at an infusion rate of 8 ml/h. RESULTS: The postoperative pain scores were lower in the trimecain/morphine group, the difference was significant during the first 6 hours after surgery, there was also a trend toward higher postoperative SpO2 values in this group, the difference was significant 36 hours after surgery. The total sum of postoperative complications and side effects was significantly higher in the bupivacian/fentanyl group (p = 0.002). CONCLUSION: The combination of epidural trimecaine with morphine after a major urological surgery provides a superior analgesia with fewer side effects when compared to epidurally delivered bupivacaine with fentanyl (Tab. 2, Fig. 5, Ref. 17). Full Text (Free, PDF) www.bmj.sk.


Assuntos
Analgesia Epidural , Analgésicos Opioides , Anestésicos Locais , Dor Pós-Operatória/prevenção & controle , Procedimentos Cirúrgicos Urológicos , Analgésicos Opioides/administração & dosagem , Anestésicos Locais/administração & dosagem , Bupivacaína/administração & dosagem , Combinação de Medicamentos , Feminino , Fentanila/administração & dosagem , Humanos , Masculino , Pessoa de Meia-Idade , Morfina/administração & dosagem , Medição da Dor , Trimecaína/administração & dosagem
9.
Int J Exp Pathol ; 87(4): 283-8, 2006 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16875493

RESUMO

The proportion of fucosylated glycoconjugate-containing rabbit tracheal goblet cells after intratracheal application of trimecaine was studied to evaluate its possible unfavourable effects. This lapine model is comparable with diagnostic findings in humans because airway epithelia in humans and rabbits are similar; tracheal epithelium is also practically identical to bronchial epithelium in both species. Local trimecaine anaesthesia caused a proportional decrease in percentage of the tracheal goblet cells containing both alpha(1-2)- and alpha(1-6)-, alpha(1-3)- and alpha(1-4)-fucosylated glycoconjugates as revealed 10 min postexposure using lectin histochemistry. In previous studies, only mild ultrastructural damage to the airway's epithelium was revealed, but a conspicuous decrease in sialylated glycoconjugate-containing tracheal goblet cells and the dominance of acidic sulphated glycoconjugates were observed as after-effects of the same treatment. Glycoconjugate changes can influence the inner environment of airways (e.g. viscoelastic properties of the airways' mucus and mucosal barrier functions) and thus the patient's defence barriers in airways may be weakened. Concurrently, the histochemical properties of goblet cells can be altered in bronchoscopic specimens. Since trimecaine is widely used as local anaesthesia in airways in bronchoscopy, it is necessary to heed these aforementioned effects.


Assuntos
Anestesia Endotraqueal/efeitos adversos , Anestésicos Locais/administração & dosagem , Glicoconjugados/metabolismo , Células Caliciformes/metabolismo , Trimecaína/administração & dosagem , Administração Tópica , Anestésicos Locais/efeitos adversos , Animais , Esquema de Medicação , Fucose/metabolismo , Glicoconjugados/análise , Células Caliciformes/química , Células Caliciformes/efeitos dos fármacos , Histocitoquímica/métodos , Lectinas/metabolismo , Masculino , Coelhos , Traqueia , Trimecaína/efeitos adversos
10.
Bull Exp Biol Med ; 139(6): 688-91, 2005 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16224582

RESUMO

Complex electrophysiological study of the effects of quaternidine carried out on intact hearts from cats, myocardial fragments from rats, and single ionic channels of large edible snail showed that quaternidine demonstrates properties of class 1B antiarrhythmic drug according to Vaughan-Williams nomenclature. This agent did not suppress nomotopic pacemaker automaticity, did not change conduction in ventricles, atria, and atrioventricular junction in hearts with preserved sinus rhythm, did not prolong refractoriness of the atria and atrioventricular junction, but prolonged efficient refractory period of heart ventricles. Quaternidine decelerated rapid depolarization of the action potential, but had no effect on its duration. It did not affect potassium conductance.


Assuntos
Antiarrítmicos/classificação , Antiarrítmicos/farmacologia , Potenciais da Membrana/efeitos dos fármacos , Compostos de Amônio Quaternário/farmacologia , Trimecaína/análogos & derivados , Potenciais de Ação/efeitos dos fármacos , Animais , Gatos , Eletrocardiografia , Eletrodos , Eletrofisiologia , Átrios do Coração/efeitos dos fármacos , Sistema de Condução Cardíaco/efeitos dos fármacos , Ventrículos do Coração/efeitos dos fármacos , Neurônios/efeitos dos fármacos , Músculos Papilares/efeitos dos fármacos , Técnicas de Patch-Clamp , Ratos , Caramujos , Trimecaína/farmacologia
11.
Ceska Slov Farm ; 54(2): 96-9, 2005 Mar.
Artigo em Eslovaco | MEDLINE | ID: mdl-15895974

RESUMO

Rheological properties exert influence on the manufacturing processes, stability and usability of a dosage form as well as the biological availability of an active ingredient. The present paper examines the effect of Carbopol 980 concentration on rheological properties of hydrogels with and without trimecainium chloride for a period of 2, 7, and 14 days after their preparation. On the basis of an evaluation of the changes in structural viscosity in dependence on the period of measurement, it has been concluded that for formulation of trimecainium chloride to a dermal dosage form, Carbopol 980 concentrations of 0.5 and 1.2 % are suitable.


Assuntos
Resinas Acrílicas/química , Anestésicos Locais , Hidrogéis/química , Trimecaína , Fenômenos Químicos , Físico-Química , Reologia
12.
Eksp Klin Farmakol ; 67(2): 24-6, 2004.
Artigo em Russo | MEDLINE | ID: mdl-15188755

RESUMO

The results of experiments on cats showed that quaternidine, a quaternary ammonium derivative of trimecaine, does not induce significant variations in the hemodynamic parameters, being advantageous in this respect to some well-known antiarrhythmic drugs. LKhT-3-00 (dialkylaminophenylacetamide glutaminate)--a tertiary derivative of lidocaine--leads to a slight decrease in the heart rate, an insignificant decrease in the arterial pressure for 10 min, and a pronounced enhancement of the pumping ability of the left ventricle over a time period of 30 min.


Assuntos
Antiarrítmicos/efeitos adversos , Hemodinâmica/efeitos dos fármacos , Lidocaína/análogos & derivados , Lidocaína/efeitos adversos , Compostos de Amônio Quaternário/efeitos adversos , Trimecaína/efeitos adversos , Animais , Gatos , Feminino , Masculino , Trimecaína/análogos & derivados
13.
Eksp Klin Farmakol ; 66(5): 22-4, 2003.
Artigo em Russo | MEDLINE | ID: mdl-14650209

RESUMO

The results of experiments on dogs showed that quaternidine, a quaternary ammonium derivative of trimecaine, produces a significant antiarrhythmogenic effect in cases of rhythm disorders in the late stage of a model myocardial infarction. For drugs administered in a single isotoxic dose, the therapeutic effect of quaternidine in animals with acute myocardial ischemia considerably exceeds the duration of action of lidocaine and trimecaine.


Assuntos
Antiarrítmicos/uso terapêutico , Compostos de Amônio Quaternário/uso terapêutico , Trimecaína/uso terapêutico , Complexos Ventriculares Prematuros/tratamento farmacológico , Animais , Modelos Animais de Doenças , Cães , Eletrocardiografia , Feminino , Frequência Cardíaca/efeitos dos fármacos , Masculino , Quinidina/uso terapêutico , Trimecaína/análogos & derivados , Complexos Ventriculares Prematuros/fisiopatologia
14.
Eksp Klin Farmakol ; 66(3): 29-31, 2003.
Artigo em Russo | MEDLINE | ID: mdl-12924229

RESUMO

The results of experiments on cats and dogs showed that quaternidine, a quaternary ammonium derivative of trimecaine, exceeds the structural precursors (trimecaine and lidocaine), as well as the reference drugs quinidine and propranolol, in intensity of the antiarrhythmic action upon single administration on the occlusive and reperfusive arrhythmia models. The therapeutic effect of quaternidine in animals with acute myocardial ischemia lasts for about 8 h, which more than 20 times longer as compared to the duration of action of both lidocaine and trimecaine.


Assuntos
Antiarrítmicos/farmacologia , Arritmias Cardíacas/prevenção & controle , Isquemia Miocárdica/complicações , Compostos de Amônio Quaternário/farmacologia , Trimecaína/análogos & derivados , Trimecaína/farmacologia , Animais , Arritmias Cardíacas/etiologia , Gatos , Cães
15.
Eksp Klin Farmakol ; 65(3): 71-4, 2002.
Artigo em Russo | MEDLINE | ID: mdl-12227104

RESUMO

An analysis of the experimental data showed that anesthetic medicinal films (AMFs) offer an effective medicinal form for the treatment of suppurative inflammatory disorders(SIDs) of soft tissues. The results of preclinical experiments with AMFs showed evidence of anesthetic, antimicrobial, and hemostatic effects. The therapeutic effect was established in the course of clinical investigations and confirmed by the results of cytological, histological, morphological, and bacteriological testing. The experimental data indicate that AMF application offers a promising means of SID treatment. Further development of this medicinal form must lead to an increase in the therapeutic efficacy, decrease the drug dose, and reduce the probability of side effects during the treatment of SIDs in soft tissues of various localization.


Assuntos
Anestesia/métodos , Anestésicos Locais/uso terapêutico , Anti-Infecciosos Locais/uso terapêutico , Clorexidina/análogos & derivados , Clorexidina/uso terapêutico , Hemostáticos/uso terapêutico , Trimecaína/uso terapêutico , Adulto , Alginatos , Anestésicos Locais/administração & dosagem , Animais , Anti-Infecciosos Locais/administração & dosagem , Carboximetilcelulose Sódica , Clorexidina/administração & dosagem , Portadores de Fármacos , Feminino , Ácido Glucurônico , Hemostáticos/administração & dosagem , Ácidos Hexurônicos , Humanos , Masculino , Pessoa de Meia-Idade , Coelhos , Ratos , Supuração/tratamento farmacológico , Infecção da Ferida Cirúrgica/tratamento farmacológico , Trimecaína/administração & dosagem , Cicatrização/efeitos dos fármacos
16.
Biofizika ; 47(2): 331-7, 2002.
Artigo em Russo | MEDLINE | ID: mdl-11969173

RESUMO

The effect of external magnetic field (direct and alternating) on the targeted delivery and distribution in body tissues of experimental animals of anesthetics (novocain, lidocaine, and trimecaine) immobilized on highly dispersed ferromagnetics with biocompatible coating was studied by the method of emission spectral analysis. The results are compared with the results obtained earlier on highly dispersed iron powders with dextran coating. The parameters for the powders with dextran coating are considerably lower than those for the magnetic carriers with the polyacrylamide coating.


Assuntos
Resinas Acrílicas , Anestésicos/farmacocinética , Sistemas de Liberação de Medicamentos , Ferro , Magnetismo , Anestésicos/administração & dosagem , Animais , Portadores de Fármacos , Lidocaína/administração & dosagem , Lidocaína/farmacocinética , Microesferas , Tamanho da Partícula , Pós , Procaína/administração & dosagem , Procaína/farmacocinética , Coelhos , Distribuição Tecidual , Trimecaína/administração & dosagem , Trimecaína/farmacocinética
17.
Rozhl Chir ; 81(10): 519-22, 2002 Oct.
Artigo em Tcheco | MEDLINE | ID: mdl-12564092

RESUMO

In a prospective randomized study the hypothesis was tested whether infiltration of the thyroid capsule by a local anaesthetic will reduce the haemodynamic response to surgical trauma, consumption of anaesthetics and opioids during surgery and will shorten the time of arousal. A total of 64 patients indicated for planned goitre surgery were divided at random into a control group (C, n = 32) and experimental group (LA, n = 32). The preoperative medication and anesthesia did not differ in the two groups. In group C into the thyroid capsule a maximum of 40 ml saline was administered, in LA the same volume of 0.5% trimecain. A highly significant difference was found (p < 0.001) in the incidence of hypertension during surgery (21 C vs. 5 LA) and the need of further pharmacological interventions (21 vs. 8). In the control group was a higher consumption (p < 0.95) of the opioid phentanyl (167.5 +/- 111 micrograms vs. 125 +/- 93.5 micrograms), a trend of longer arousal and the need to antagonize the effect of opioid (p < 0.1). The substitution of saline by a local anaesthetic for infiltration of the thyroid capsule is a safe and simple method leading to a reduction of cardiovascular complications during surgery.


Assuntos
Anestesia Geral , Anestésicos Locais/administração & dosagem , Injeções , Glândula Tireoide , Tireoidectomia , Trimecaína/administração & dosagem , Feminino , Humanos , Complicações Intraoperatórias/prevenção & controle , Masculino , Pessoa de Meia-Idade , Dor Pós-Operatória/prevenção & controle , Estudos Prospectivos
18.
Lik Sprava ; (4): 112-5, 2001.
Artigo em Russo | MEDLINE | ID: mdl-11692688

RESUMO

In 231 patient with chronic renal impairment (CRI) the quality was studied of epidural anesthesia with different doses and concentrations of lidocaine hydrochloride, prilocaine hydrochloride, trimecaine hydrochloride, and bupivacaine. In patients in the terminal stage of CRI placed on the program-hemodialysis, the use of standard concentrations and volumes of the local anesthetsic (LA) has been found out to be associated with lower levels of the sensory and motor blocks than in CRI-free patients or in other stages of CRI. Intensification of epidural anesthesia in the above patients is achieved through employing a higher concentration of LA or epidural administration of narcotic analgesics and/or cloffelin. Patients with other stages of CRI do not require the renal-insufficiency stage-dependent correction of LA dose, an optimum option being administration of 2% solution of lidocaine and prilocaine, 2.5% solution of trimecaine and 0.5% solution of bupivacaine, 1.5% ml, on the spinal segment in combination with adjuvant drugs.


Assuntos
Anestesia Epidural/métodos , Falência Renal Crônica/terapia , Analgésicos/administração & dosagem , Anestesia Epidural/efeitos adversos , Anestésicos Locais/administração & dosagem , Bupivacaína/administração & dosagem , Clonidina/administração & dosagem , Humanos , Lidocaína/administração & dosagem , Masculino , Atividade Motora/efeitos dos fármacos , Prilocaína/administração & dosagem , Diálise Renal , Limiar Sensorial/efeitos dos fármacos , Trimecaína/administração & dosagem
20.
Biofizika ; 45(6): 1066-71, 2000.
Artigo em Russo | MEDLINE | ID: mdl-11155234

RESUMO

The orientation interaction of a molecule of a local anesthetic with a biomembrane and cell-like liquid was studied, based on the model of adsorption of the anesthetic from a cell-like solution on the surface of a biomembrane for compounds of the trimecaine series. A statistically significant correlation equation was obtained, which relates the minimum blocking concentration to the projection of the dipole moment of the anesthetic on the plane X(1)0X2 of the principal axes of inertia. A model is prosed according to which the "anesthetic-biomembrane" interaction is most effective the molecule of the anesthetic rotates around the axis of the maximum moment of inertia.


Assuntos
Anestésicos Locais/farmacologia , Anestésicos Locais/química , Membrana Celular/química , Membrana Celular/efeitos dos fármacos , Lipídeos de Membrana/química , Trimecaína/química , Trimecaína/farmacologia
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