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1.
Skin Res Technol ; 30(7): e13768, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38961690

RESUMO

BACKGROUND: The majority of conventional studies on skin aging have focused on static conditions. However, in daily life, the facial skin we encounter is constantly in motion due to conversational expressions and changes in facial expressions, causing the skin to alter its position and shape, resulting in a dynamic state. Consequently, it is hypothesized that characteristics of aging not apparent in static conditions may be present in the dynamic state of the skin. Therefore, this study investigates age-related changes in dynamic skin characteristics associated with facial expression alterations. METHODS: A motion capture system measured the dynamic characteristics (delay and stretchiness of skin movement associated with expression) of the cheek skin in response to facial expressions among 86 Japanese women aged between 20 and 69 years. RESULTS: The findings revealed an increase in the delay of cheek skin response to facial expressions (r = 0.24, p < 0.05) and a decrease in the stretchiness of the lower cheek area with age (r = 0.60, p < 0.01). An increasing variance in delay and stretchiness within the same age group was also observed with aging. CONCLUSION: The findings of this study revealed that skin aging encompasses both static characteristics, such as spots, wrinkles, and sagging, traditionally studied in aging research, and dynamic aging characteristics of the skin that emerge in response to facial expression changes. These dynamic aging characteristics could pave the way for the development of new methodologies in skin aging analysis and potentially improve our understanding and treatment of aging impressions that are visually perceptible in daily life but remain unexplored.


Assuntos
Bochecha , Expressão Facial , Envelhecimento da Pele , Humanos , Feminino , Bochecha/fisiologia , Pessoa de Meia-Idade , Adulto , Envelhecimento da Pele/fisiologia , Idoso , Japão , Adulto Jovem , Movimento/fisiologia , Pele , Envelhecimento/fisiologia , Fenômenos Fisiológicos da Pele , População do Leste Asiático
2.
Photodermatol Photoimmunol Photomed ; 40(4): e12987, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38968385

RESUMO

BACKGROUND: Skin microbiota is essential for health maintenance. Photoaging is the primary environmental factor that affects skin homeostasis, but whether it influences the skin microbiota remains unclear. OBJECTIVE: The objective of this study is to investigate the relationship between photoaging and skin microbiome. METHODS: A cohort of senior bus drivers was considered as a long-term unilateral ultraviolet (UV) irradiated population. 16S rRNA amplicon sequencing was conducted to assess skin microbial composition variations on different sides of their faces. The microbiome characteristics of the photoaged population were further examined by photoaging guinea pig models, and the correlations between microbial metabolites and aging-related cytokines were analyzed by high-throughput sequencing and reverse transcription polymerase chain reaction. RESULTS: Photoaging decreased the relative abundance of microorganisms including Georgenia and Thermobifida in human skin and downregulated the generation of skin microbe-derived antioxidative metabolites such as ectoin. In animal models, Lactobacillus and Streptobacillus abundance in both the epidermis and dermis dropped after UV irradiation, resulting in low levels of skin antioxidative molecules and leading to elevated expressions of the collagen degradation factors matrix metalloproteinase (MMP)-1 and MMP-2 and inflammatory factors such as interleukin (IL)-1ß and IL-6. CONCLUSIONS: Skin microbial characteristics have an impact in photoaging and the loss of microbe-derived antioxidative metabolites impairs skin cells and accelerates the aging process. Therefore, microbiome-based therapeutics may have potential in delaying skin aging.


Assuntos
Microbiota , Envelhecimento da Pele , Pele , Raios Ultravioleta , Humanos , Animais , Cobaias , Pele/microbiologia , Pele/metabolismo , Masculino , Feminino , Pessoa de Meia-Idade , RNA Ribossômico 16S
3.
J Drugs Dermatol ; 23(7): 504-509, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38954621

RESUMO

Photoaging is a complex, ongoing process that clinically manifests as cutaneous rhytides, atrophy, laxity, dyspigmentation, telangiectasias, roughness, and mottled appearance of the skin. There is an abundance of research establishing the mechanism of ultraviolet (UV) - induced photodamage as it is a significant source of photoaging and skin cancers. While UV damage is known to induce photoaging, it is important to understand how other forms of light radiation also contribute to this process. UV only constitutes 5 to 10% of solar radiation that reaches the earth's surface. The remaining nearly 90% is evenly split between infrared and visible light radiation. Early research shows that varied skin types may elicit different photobiologic responses to light. This article presents the mechanisms and biomarkers of photodamage induced by light from across the spectrum, including UV, visible light, and infrared to better prevent and reverse the damage of photoaging in all skin types.J Drugs Dermatol. 2024;23(7):504-509.  doi:10.36849/JDD.7438.


Assuntos
Envelhecimento da Pele , Pele , Raios Ultravioleta , Envelhecimento da Pele/efeitos da radiação , Humanos , Raios Ultravioleta/efeitos adversos , Pele/efeitos da radiação , Pele/patologia , Raios Infravermelhos/efeitos adversos , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/etiologia
4.
J Drugs Dermatol ; 23(7): 538-544, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38954629

RESUMO

BACKGROUND: All skin tones need to be protected from the damaging effects of solar radiation. Although mineral sunscreens offer protection, they can have a thick, greasy feel and leave a white cast, particularly on darker skin tones. Tints offset white cast and provide visible light protection; however, patients may prefer a sheer option. Therefore, a multifunctional, sheer, 100% mineral sunscreen moisturizer (MSM) with broad-spectrum SPF 50 was developed to have positive aesthetics and deliver anti-aging and skin health benefits to all skin tones.  Methods: An IRB-approved, 12-week, open-label clinical study was conducted to investigate the efficacy and tolerability of the MSM. Thirty-nine (39) females aged 35 to 60 years with moderate-severe overall facial photodamage and representing all Fitzpatrick skin types (FST) were recruited. Participants applied the MSM to the face and neck in the morning and reapplied per US Food and Drug Administration requirements. Efficacy and tolerability grading, photography, ultrasound imaging, corneometer measurements, and questionnaires were completed at baseline and weeks 4, 8, and 12.  Results: Statistically significant progressive improvements were demonstrated from baseline to week 12. At week 12, 23.4% and 26.5% mean improvements in overall photodamage were seen for FST I-III and FST IV-VI, respectively. Favorable tolerability was shown for both the face and neck. Photography corroborated clinical grading, and ultrasound imaging indicated a trend in skin density improvement. The MSM was well-perceived.  Conclusion: The MSM is an efficacious and well-tolerated product for patients of all skin tones who desire a sheer, 100% mineral sunscreen moisturizer with anti-aging and skin health benefits. J Drugs Dermatol. 2024;23(7):538-544.  doi:10.36849/JDD.8082.


Assuntos
Envelhecimento da Pele , Pigmentação da Pele , Protetores Solares , Humanos , Feminino , Pessoa de Meia-Idade , Adulto , Protetores Solares/administração & dosagem , Protetores Solares/efeitos adversos , Envelhecimento da Pele/efeitos dos fármacos , Pigmentação da Pele/efeitos dos fármacos , Pigmentação da Pele/efeitos da radiação , Creme para a Pele/administração & dosagem , Creme para a Pele/efeitos adversos , Face , Resultado do Tratamento , Administração Cutânea , Fator de Proteção Solar
5.
J Drugs Dermatol ; 23(7): 551-556, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38954627

RESUMO

BACKGROUND: Calcium hydroxylapatite (CaHA) dermal filler is used for a variety of aesthetic treatments; however, the safety and effectiveness of diluted CaHA for the treatment of décolleté wrinkles have not been established. OBJECTIVE: To demonstrate the effectiveness and safety of diluted CaHA (Radiesse; 1:2 CaHA:saline) injection for the improvement of décolleté wrinkles in females. METHODS: Eligible females with moderate or severe ratings on the Merz Aesthetic Scale (MAS) Decollete Wrinkles - At Rest received up to 3 injection cycles of diluted CaHA either 8 weeks apart (3 injection cycles) or 16 weeks apart (2 injection cycles). Effectiveness was evaluated by improvement on the MAS. Adverse events were recorded over a 52 week period. RESULTS: Sixteen weeks after the last treatment, the response rate (1-point improvement or greater) on the MAS Decollete Wrinkles - At Rest was 73.5% (P<0.0001; pooled sample) for all patients. The use of diluted CaHA in the decollete also demonstrated a favorable safety profile. CONCLUSIONS: Diluted CaHA is a safe and effective treatment for the improvement of decollete wrinkles in females.J Drugs Dermatol. 2024;23(7):551-556.  doi:10.36849/JDD.8261.


Assuntos
Preenchedores Dérmicos , Durapatita , Envelhecimento da Pele , Humanos , Feminino , Envelhecimento da Pele/efeitos dos fármacos , Durapatita/administração & dosagem , Durapatita/efeitos adversos , Estudos Prospectivos , Pessoa de Meia-Idade , Preenchedores Dérmicos/administração & dosagem , Preenchedores Dérmicos/efeitos adversos , Resultado do Tratamento , Técnicas Cosméticas , Adulto , Método Simples-Cego , Idoso
7.
Skin Res Technol ; 30(7): e13669, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38965805

RESUMO

BACKGROUND: To date, studies examining the effect of air pollution on skin characteristics have relied on regional pollution estimates obtained from fixed monitoring sites. Hence, there remains a need to characterize the impact of air pollution in vivo in real-time conditions. We conducted an initial investigation under real-life conditions, with the purpose of characterizing the in vivo impact of various pollutants on the facial skin condition of women living in Paris over a 6-month period. MATERIALS AND METHODS: A smartphone application linked to the Breezometer platform was used to collect participants' individual exposures to pollutants through the recovery of global positioning system (GPS) data over a 6-month period. Daily exposure to fine particulate matter (PM 2.5 µm and PM 10 µm), pollen, and air quality was measured. Facial skin color, roughness, pore, hydration, elasticity, and wrinkle measurements were taken at the end of the 6-month period. Participants' cumulated pollutant exposure over 6 months was calculated. Data were stratified into two groups (lower vs. higher pollutant exposure) for each pollutant. RESULTS: 156 women (20-60 years-old) were recruited, with 124 women completing the study. Higher PM 2.5 µm exposure was associated with altered skin color and increased roughness under the eye. Higher PM 10 µm exposure with increased wrinkles and roughness under the eye, increased pore appearance, and decreased skin hydration. Exposure to poorer air quality was linked with increased forehead wrinkles and decreased skin elasticity, while higher pollen exposure increased skin roughness and crow's feet. CONCLUSION: This study suggests a potential correlation between air pollution and facial skin in real-life conditions. Prolonged exposure to PM, gases, and pollen may be linked to clinical signs of skin ageing. This study highlights the importance of longer monitoring over time in real conditions to characterize the effect of pollution on the skin.


Assuntos
Poluição do Ar , Exposição Ambiental , Face , Material Particulado , Envelhecimento da Pele , Adulto , Feminino , Humanos , Pessoa de Meia-Idade , Adulto Jovem , Poluição do Ar/efeitos adversos , Exposição Ambiental/efeitos adversos , Monitoramento Ambiental/métodos , Sistemas de Informação Geográfica , Paris , Material Particulado/efeitos adversos , Pólen , Pele/efeitos dos fármacos , Envelhecimento da Pele/efeitos dos fármacos , Smartphone , População Branca
8.
Medicina (Kaunas) ; 60(6)2024 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-38929564

RESUMO

The prevalence of skin aging and the request for effective treatments have driven dermatological research towards natural solutions. This study investigates the anti-aging efficacy of two bioactive natural polyphenols, Oleocanthal and Oleacein, in a skincare formulation. A single-blind, randomized clinical trial involved 70 participants, using a comprehensive exclusion criterion to ensure participant safety and study integrity. Participants applied the Oleocanthal and Oleacein 1% serum formulation twice daily for 30 days. The efficacy was objectively assessed using the VISIA® Skin Analysis System at baseline, after 15 days, and after 30 days. Results indicated significant wrinkle reduction in most groups. For women aged 45-79 years, the mean change was -33.91% (95% CI: -46.75% to -21.07%). For men aged 20-44 years, it was -51.93% (95% CI: -76.54% to -27.33%), and for men aged 45-79 years, it was -46.56% (95% CI: -58.32% to -34.81%). For women aged 20-44 years, the change was -25.68% (95% CI: -63.91% to 12.54%), not statistically significant. These findings highlight the potential of EVOO-derived polyphenols in anti-aging skincare, particularly for older adults. This research paves the way for further exploration into natural compounds in dermatology, particularly for aging skin management.


Assuntos
Aldeídos , Monoterpenos Ciclopentânicos , Fenóis , Envelhecimento da Pele , Humanos , Pessoa de Meia-Idade , Feminino , Masculino , Idoso , Adulto , Envelhecimento da Pele/efeitos dos fármacos , Método Simples-Cego , Fenóis/uso terapêutico , Fenóis/farmacologia
9.
Molecules ; 29(12)2024 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-38930783

RESUMO

Ultraviolet B (UVB) exposure can contribute to photoaging of skin. Cornus officinalis is rich in ursolic acid (UA), which is beneficial to the prevention of photoaging. Because UA is hardly soluble in water, the Cornus officinalis extract (COE) was obtained using water as the antisolvent to separate the components containing UA from the crude extract of Cornus officinalis. The effect of COE on UVB damage was assessed using Caenorhabditis elegans. The results showed that COE could increase the lifespan and enhance the antioxidant enzyme activity of C. elegans exposed to UVB while decreasing the reactive oxygen species (ROS) level. At the same time, COE upregulated the expression of antioxidant-related genes and promoted the migration of SKN-1 to the nucleus. Moreover, COE inhibited the expression of the skn-1 downstream gene and the extension of the lifespan in skn-1 mutants exposed to UVB, indicating that SKN-1 was required for COE to function. Our findings indicate that COE mainly ameliorates the oxidative stress caused by UVB in C. elegans via the SKN-1/Nrf2 pathway.


Assuntos
Antioxidantes , Proteínas de Caenorhabditis elegans , Caenorhabditis elegans , Cornus , Estresse Oxidativo , Extratos Vegetais , Triterpenos , Raios Ultravioleta , Ácido Ursólico , Animais , Caenorhabditis elegans/efeitos dos fármacos , Caenorhabditis elegans/metabolismo , Triterpenos/farmacologia , Triterpenos/química , Raios Ultravioleta/efeitos adversos , Extratos Vegetais/farmacologia , Extratos Vegetais/química , Proteínas de Caenorhabditis elegans/metabolismo , Proteínas de Caenorhabditis elegans/genética , Estresse Oxidativo/efeitos dos fármacos , Cornus/química , Antioxidantes/farmacologia , Antioxidantes/química , Espécies Reativas de Oxigênio/metabolismo , Envelhecimento da Pele/efeitos dos fármacos , Envelhecimento da Pele/efeitos da radiação , Fatores de Transcrição/metabolismo , Fatores de Transcrição/genética , Proteínas de Ligação a DNA/metabolismo , Proteínas de Ligação a DNA/genética , Longevidade/efeitos dos fármacos , Longevidade/efeitos da radiação , Fator 2 Relacionado a NF-E2/metabolismo , Fator 2 Relacionado a NF-E2/genética
10.
Nutrients ; 16(12)2024 Jun 17.
Artigo em Inglês | MEDLINE | ID: mdl-38931263

RESUMO

Collagen dietary supplements are becoming increasingly popular as a means to reduce signs of skin ageing. The objective of this three-way, randomised, placebo-controlled, double-blind study was to examine and contrast the effects of dietary supplementation with a daily dose of 5 g hydrolysed collagen with 80 mg of vitamin C (CP product) and their combination with 30 mg of hyaluronic acid (CPHA product) over 16 weeks. Validated methods were utilised for the objective evaluation of skin parameters. In total, 87 subjects (women, 40-65 years) completed the entire trial, distributed across the groups as follows: placebo group (n = 29), CPHA group (n = 28), and CP group (n = 30). The results showed beneficial effects of both test products, with notable enhancements in dermis density, skin texture, and a reduction in the severity of wrinkles. In contrast, the administration of either of the products did not yield any significant impacts on skin elasticity or hydration. Observation of the investigated skin parameters did not show superior effects of the addition of hyaluronic acid (HA) to collagen. Therefore, the ability of supplementation with HA to improve the effects on investigated skin parameters beyond the supplementation of collagen alone cannot be confirmed.


Assuntos
Ácido Ascórbico , Colágeno , Suplementos Nutricionais , Ácido Hialurônico , Envelhecimento da Pele , Pele , Humanos , Ácido Hialurônico/administração & dosagem , Ácido Ascórbico/administração & dosagem , Ácido Ascórbico/farmacologia , Pessoa de Meia-Idade , Método Duplo-Cego , Feminino , Colágeno/administração & dosagem , Envelhecimento da Pele/efeitos dos fármacos , Adulto , Idoso , Pele/efeitos dos fármacos , Masculino
11.
Nutrients ; 16(12)2024 Jun 17.
Artigo em Inglês | MEDLINE | ID: mdl-38931262

RESUMO

The skin, serving as the body's primary defense against external elements, plays a crucial role in protecting the body from infections and injuries, as well as maintaining overall homeostasis. Skin aging, a common manifestation of the aging process, involves the gradual deterioration of its normal structure and repair mechanisms. Addressing the issue of skin aging is increasingly imperative. Multiple pieces of evidence indicate the potential anti-aging effects of exogenous nucleotides (NTs) through their ability to inhibit oxidative stress and inflammation. This study aims to investigate whether exogenous NTs can slow down skin aging and elucidate the underlying mechanisms. To achieve this objective, senescence-accelerated mouse prone-8 (SAMP8) mice were utilized and randomly allocated into Aging, NTs-low, NTs-middle, and NTs-high groups, while senescence-accelerated mouse resistant 1 (SAMR1) mice were employed as the control group. After 9 months of NT intervention, dorsal skin samples were collected to analyze the pathology and assess the presence and expression of substances related to the aging process. The findings indicated that a high-dose NT treatment led to a significant increase in the thickness of the epithelium and dermal layers, as well as Hyp content (p < 0.05). Additionally, it was observed that low-dose NT intervention resulted in improved aging, as evidenced by a significant decrease in p16 expression (p < 0.05). Importantly, the administration of high doses of NTs could improve, in some ways, mitochondrial function, which is known to reduce oxidative stress and promote ATP and NAD+ production significantly. These observed effects may be linked to NT-induced autophagy, as evidenced by the decreased expression of p62 and increased expression of LC3BI/II in the intervention groups. Furthermore, NTs were found to upregulate pAMPK and PGC-1α expression while inhibiting the phosphorylation of p38MAPK, JNK, and ERK, suggesting that autophagy may be regulated through the AMPK and MAPK pathways. Therefore, the potential induction of autophagy by NTs may offer benefits in addressing skin aging through the activation of the AMPK pathway and the inhibition of the MAPK pathway.


Assuntos
Proteínas Quinases Ativadas por AMP , Autofagia , Nucleotídeos , Envelhecimento da Pele , Animais , Envelhecimento da Pele/efeitos dos fármacos , Autofagia/efeitos dos fármacos , Camundongos , Proteínas Quinases Ativadas por AMP/metabolismo , Nucleotídeos/farmacologia , Estresse Oxidativo/efeitos dos fármacos , Pele/efeitos dos fármacos , Pele/metabolismo , Masculino , Sistema de Sinalização das MAP Quinases/efeitos dos fármacos , Transdução de Sinais/efeitos dos fármacos , Proteínas Quinases Ativadas por Mitógeno/metabolismo
12.
Skin Res Technol ; 30(7): e13790, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38932444

RESUMO

BACKGROUND: The delicate periorbital region is susceptible to skin dehydration, wrinkles, and loss of elasticity. Thus, targeted and effective anti-aging interventions are necessary for the periorbital area. AIM: To evaluate the efficacy and safety of a new anti-aging eye cream formulated with the active complex (Yeast/rice fermentation filtrate, N-acetylneuraminic acid, palmityl tripeptide-1, and palmitoyl tetrapeptide-7). METHODS: The cell viability and expressions of key extracellular matrix (ECM) components of the active complex were evaluated using a human skin fibroblast model. In the 12-week clinical trial, skin hydration, elasticity, facial photographs, and collagen density following eye cream application were assessed using Corneometer, Cutometer, VISIA, and ultrasound device, respectively. Dermatologists and participants evaluated clinical efficacy and safety at baseline, and after 4, 8, and 12 weeks. RESULTS: PCR and immunofluorescent analyses revealed that the active complex significantly stimulated fibroblast proliferation (p < 0.05) and markedly promote the synthesis of collagen and elastin. Clinical findings exhibited a substantial enhancement in skin hydration (28.12%), elasticity (18.81%), and collagen production (54.99%) following 12 weeks of eye cream application. Dermatological evaluations and participants' assessments reported a significant improvement in skin moisture, roughness, elasticity, as well as fine lines and wrinkles by week 8. CONCLUSION: The new anti-aging eye cream, enriched with the active complex, demonstrates comprehensive rejuvenating effects, effectively addressing aging concerns in the periorbital area, coupled with a high safety profile.


Assuntos
Fibroblastos , Envelhecimento da Pele , Creme para a Pele , Humanos , Envelhecimento da Pele/efeitos dos fármacos , Fibroblastos/efeitos dos fármacos , Feminino , Pessoa de Meia-Idade , Creme para a Pele/administração & dosagem , Adulto , Elasticidade/efeitos dos fármacos , Colágeno , Sobrevivência Celular/efeitos dos fármacos , Elastina , Masculino , Pele/efeitos dos fármacos , Pele/patologia , Resultado do Tratamento , Administração Tópica , Proliferação de Células/efeitos dos fármacos , Idoso
13.
Int Ophthalmol Clin ; 64(3): 13-22, 2024 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-38910501

RESUMO

The integration of skincare into medical practice can enhance patient care. Understanding the anatomy and physiology of the skin is the foundation for effective skincare interventions. Genetic and inflammatory conditions play a significant role in aesthetic skin physiology. There are key active ingredients that are pivotal in addressing various skin concerns. Sunscreens provide crucial protection against UV radiation, while pigment control agents such as hydroquinone, kojic acid, and arbutin target the melanin pathway. Exfoliating agents and skin turnover enhancers such as retinoids and hydroxy acids promote skin renewal and rejuvenation. In addition, ingredients such as hyaluronic acid, ceramides, niacinamide, antioxidants, peptides, and botanicals contribute to improving skin quality. Adding skincare to medical practice requires careful product selection, patient education, and marketing strategies.


Assuntos
Higiene da Pele , Humanos , Higiene da Pele/métodos , Protetores Solares/uso terapêutico , Envelhecimento da Pele/fisiologia , Dermatopatias/terapia , Fármacos Dermatológicos/uso terapêutico
16.
Arch Dermatol Res ; 316(6): 328, 2024 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-38824251

RESUMO

Observational studies have revealed associations between various dietary factors and skin conditions. However, the causal relationship between diet and skin condition is still unknown. Data on 17 dietary factors were obtained from the UK Biobank. Data on four skin conditions were derived from the UK Biobank and another large-scale GWAS study. Genetic predictions suggested that the intake of oily fish was associated with a lower risk of skin aging (OR: 0.962, P = 0.036) and skin pigmentation (OR: 0.973, P = 0.033); Tea intake was associated with a lower risk of skin pigmentation (OR: 0.972, P = 0.024); Salad/raw vegetables intake was associated with a lower risk of keratinocyte skin cancer (OR: 0.952, P = 0.007). Coffee intake was associated with increased risk of skin aging (OR: 1.040, P = 0.028); Pork intake was associated with increased risk of skin aging (OR: 1.134, P = 0.020); Beef intake was associated with increased risk of cutaneous melanoma (OR: 1.013, P = 0.016); Champagne plus white wine intake was associated with increased risk of cutaneous melanoma (OR: 1.033, P = 0.004); Bread intake was associated with increased risk of keratinocyte skin cancer (OR: 1.026, P = 0.013). Our study results indicate causal relationships between genetically predicted intake of oily fish, tea, salad/raw vegetables, coffee, pork, beef, champagne plus white wine, and bread and skin conditions.


Assuntos
Dieta , Análise da Randomização Mendeliana , Neoplasias Cutâneas , Humanos , Dieta/efeitos adversos , Dieta/estatística & dados numéricos , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/etiologia , Envelhecimento da Pele/genética , Pigmentação da Pele/genética , Café/efeitos adversos , Estudo de Associação Genômica Ampla , Reino Unido/epidemiologia , Chá/efeitos adversos , Fatores de Risco
17.
Arch Dermatol Res ; 316(6): 329, 2024 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-38829483

RESUMO

Dry skin is a common dermatological condition that frequently affects the elderly. A contributing cause to dry skin is a reduced concentration of hyaluronic acid (HA) in both the epidermis and dermis. The effectiveness of moisturizer containing HA as a therapy for dry skin is impacted by its specific molecular weight. Low molecular weight HA (LMWHA) is believed to be more effective in replenishing skin hydration in aging skin compared to High Molecular Weight HA (HMWHA) due to its ability to penetrate the stratum corneum. However, there is a lack of clinical research supporting this claim. A double-blind, randomized controlled trial was conducted on 36 residents of a nursing home in Jakarta. The participants, aged between 60 and 80 years, had been diagnosed with dry skin. Each test subject was administered three distinct, randomized moisturizing lotions (LMWHA, HMWHA, or vehicle), to be topically applied to three separate sites on the leg. Skin capacitance (SCap), transepidermal water loss (TEWL), and specified symptom sum score (SRRC) were measured at weeks 0, 2, and 4. After four weeks of therapy, area that was treated with LMWHA showed greater SCap values compared to the area treated with HMWHA (56.37 AU vs. 52.37 AU, p = 0.004) and vehicle (56.37 AU vs. 49.01 AU, p < 0.001). All groups did not show any significant differences in TEWL and SRRC scores. No side effects were found in all groups. The application of a moisturizer containing LMWHA to the dry skin of elderly resulted in significant improvements in skin hydration compared to moisturizers containing HMWHA and vehicle. Furthermore, these moisturizers demonstrated similar safety in treating dry skin in the elderly. ClinicalTrials.gov Identifier NCT06178367, https://clinicaltrials.gov/study/NCT06178367 .


Assuntos
Ácido Hialurônico , Peso Molecular , Humanos , Ácido Hialurônico/administração & dosagem , Idoso , Método Duplo-Cego , Feminino , Masculino , Idoso de 80 Anos ou mais , Pessoa de Meia-Idade , Resultado do Tratamento , Perda Insensível de Água/efeitos dos fármacos , Envelhecimento da Pele/efeitos dos fármacos , Dermatopatias/tratamento farmacológico , Dermatopatias/diagnóstico , Administração Cutânea , Creme para a Pele/administração & dosagem , Emolientes/administração & dosagem
18.
Arch Dermatol Res ; 316(6): 326, 2024 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-38822910

RESUMO

Skin aging is one of the visible characteristics of the aging process in humans. In recent years, different biological clocks have been generated based on protein or epigenetic markers, but few have focused on biological age in the skin. Arrest the aging process or even being able to restore an organism from an older to a younger stage is one of the main challenges in the last 20 years in biomedical research. We have implemented several machine learning models, including regression and classification algorithms, in order to create an epigenetic molecular clock based on miRNA expression profiles of healthy subjects to predict biological age-related to skin. Our best models are capable of classifying skin samples according to age groups (18-28; 29-39; 40-50; 51-60 or 61-83 years old) with an accuracy of 80% or predict age with a mean absolute error of 10.89 years using the expression levels of 1856 unique miRNAs. Our results suggest that this kind of epigenetic clocks arises as a promising tool with several applications in the pharmaco-cosmetic industry.


Assuntos
Epigênese Genética , Aprendizado de Máquina , MicroRNAs , Envelhecimento da Pele , Pele , Humanos , MicroRNAs/genética , Pessoa de Meia-Idade , Idoso , Adulto , Envelhecimento da Pele/genética , Idoso de 80 Anos ou mais , Pele/metabolismo , Pele/patologia , Feminino , Adulto Jovem , Masculino , Adolescente , Perfilação da Expressão Gênica , Relógios Biológicos/genética
19.
Cell Death Dis ; 15(6): 443, 2024 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-38914551

RESUMO

Adipose tissues in the hypodermis, the crucial stem cell reservoir in the skin and the endocrine organ for the maintenance of skin homeostasis undergo significant changes during skin aging. Dermal white adipose tissue (dWAT) has recently been recognized as an important organ for both non-metabolic and metabolic health in skin regeneration and rejuvenation. Defective differentiation, adipogenesis, improper adipocytokine production, and immunological dissonance dysfunction in dWAT lead to age-associated clinical changes. Here, we review age-related alterations in dWAT across levels, emphasizing the mechanisms underlying the regulation of aging. We also discuss the pathogenic changes involved in age-related fat dysfunction and the unfavorable consequences of accelerated skin aging, such as chronic inflammaging, immunosenescence, delayed wound healing, and fibrosis. Research has shown that adipose aging is an early initiation event and a potential target for extending longevity. We believe that adipose tissues play an essential role in aging and form a potential therapeutic target for the treatment of age-related skin diseases. Further research is needed to improve our understanding of this phenomenon.


Assuntos
Envelhecimento , Homeostase , Envelhecimento da Pele , Humanos , Envelhecimento/patologia , Envelhecimento/fisiologia , Envelhecimento da Pele/fisiologia , Animais , Pele/patologia , Pele/metabolismo , Tecido Adiposo Branco/metabolismo , Adipogenia
20.
Exp Dermatol ; 33(6): e15120, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38886965

RESUMO

Ageing is an inevitable biological process characterized by progressive decline in physiological functions. It is a complex natural phenomenon that will cause structural and functional decline. Despite substantial progress in understanding the mechanism of ageing, both predictive biomarkers and preventive therapies remain limited. Using Weighted Gene Co-expression Network Analysis (WGCNA) and machine learning techniques, we identified Carboxypeptidase E (CPE) as a pivotal marker of skin ageing, based on ageing-related bulk transcriptome and single-cell transcriptome data. Next, our investigation reveals downregulation of CPE in replicative, UVA-induced, and H2O2-induced senescent human dermal fibroblast cells (HDFs). Furthermore, shRNA-mediated CPE knockdown induced HDFs senescence, and overexpression of CPE delayed HDFs senescence. Moreover, downregulated CPE inhibits collagen synthesis and induces inflammation, highlighting its potential as a therapeutic target for skin ageing. In conclusion, our study demonstrated that CPE functions as a predictor and optional target for therapeutic intervention of skin ageing.


Assuntos
Biomarcadores , Senescência Celular , Biologia Computacional , Fibroblastos , Envelhecimento da Pele , Humanos , Envelhecimento da Pele/genética , Fibroblastos/metabolismo , Biomarcadores/metabolismo , Aprendizado de Máquina , Transcriptoma , Colágeno/metabolismo , Regulação para Baixo , Pele/metabolismo , Raios Ultravioleta , Peróxido de Hidrogênio/metabolismo
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