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1.
R I Med J (2013) ; 104(3): 8-9, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789399
2.
R I Med J (2013) ; 104(3): 10-11, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789400
3.
R I Med J (2013) ; 104(3): 12-13, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789401
4.
R I Med J (2013) ; 104(3): 16, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789402
5.
R I Med J (2013) ; 104(3): 17-21, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789403

RESUMEN

The opioid epidemic has reached into all aspects of life in the United States. The epidemic has crossed racial, economic, social, and generational barriers. This epidemic also impacts infants. Fetal exposure to opioids can produce a withdrawal effect in newborns, referred to as Neonatal Opioid Withdrawal Syndrome (NOWS). NOWS treatment lacks a standard approach, with prominent variation across the United States. Furthermore, many treatment strategies for NOWS are not evidence-based but reflect anecdotal experience. Variable approaches to NOWS treatment contribute to more extended hospital stays and greater postnatal opioid exposure. The most prolonged period of NOWS treatment occurs during the weaning phase. This paper describes the first prospective randomized control trial to address systematized weaning of opioids for infants with NOWS.

6.
R I Med J (2013) ; 104(3): 22-26, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789404

RESUMEN

Overdose deaths across the country have spiked since the onset of the COVID-19 pandemic. It is crucial now, more than ever, to address the continuing and worsening, complex and dynamic opioid and overdose epidemics. In 2018, The Center of Biomedical Research Excellence (COBRE) on Opioids and Overdose, based at Rhode Island Hospital, launched with three major goals: 1) establish a center of scientific excellence on opioids and overdose; 2) train the next generation of scientists to become independent investigators and address the opioid and overdose crises; and 3) contribute to the scientific progress and solutions to combat these epidemics. To date, we have made substantial progress. While the opioid and overdose crises continue to evolve, the COBRE on Opioid and Overdose and its team of investigators are well poised to address the daunting task of understanding and meaningfully addressing these deadly epidemics, with the ultimate goal of saving lives.

7.
R I Med J (2013) ; 104(3): 27-31, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789405

RESUMEN

The Center for Addiction and Disease Risk Exacerbation (CADRE) is a COBRE establishing a thematically linked, state-of-the-art, multidisciplinary Center investigating mechanisms where-by substance use (SU) increases the risk for or exacerbates chronic disease. It does so by employing a combination of behavioral and physiological laboratory-based approaches across several substances and across several diseases. COBRE projects investigate mechanisms underlying effects of opioids, cannabis, tobacco, and alcohol on risks for and progression of SU-related disease. Though linkages between SU and disease are well documented, physiological mechanisms underlying such associations are poorly understood, mainly because published studies use cross-sectional designs that do not allow for causal interpretations. Mechanisms studied in CADRE projects include systemic inflammation, immune system dysregulation, high blood pressure, pulmonary effects, and carcinogen exposure. A Clinical Laboratory Core provides infrastructure, resources, and scientific expertise and a center-wide database of risk factors associated with the development of SU and chronic disease.

8.
R I Med J (2013) ; 104(3): 32-35, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789406

RESUMEN

The COBRE for Perinatal Biology (CPB) was the third grant in Rhode Island to be funded by the COBRE mechanism. The CPB was based at Women & Infants Hospital, and housed in the Kilguss Research Institute, in the Jewelry District in Providence. The scientific focus of the CPB was on perinatal diseases such as preeclampsia and preterm birth, as well as more broadly on cardiopulmonary development and reproductive biology. Over the course of three phases and 17 years, the CPB funded 22 projects. CPB investigators, in turn, generated over $27.5 million in independent funding from federal and non-federal sources. Besides providing scientific and career mentorship to new investigators in Rhode Island, the CPB established a Research Core. The Kilguss Research Core remains active and flourishing and provides advanced imaging, molecular biology and flow cytometry abilities to researchers at Women & Infants as well as the greater Rhode Island scientific community.

9.
R I Med J (2013) ; 104(3): 36-40, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789407

RESUMEN

The Center of Biomedical Research Excellence (COBRE) Center for Central Nervous System Function (CCNSF) was funded in 2013 by the National Institute for General Medical Sciences to establish a collaborative environment for basic and applied research in higher nervous system function with humans and experimental animal model systems. Since its inception, the COBRE CCNSF has funded junior faculty investigators as Project and Pilot Project Leaders and one established investigator on projects investigating fundamental properties of nervous system function using a range of tools spanning molecular genetics, neurophysiology, invasive and non-invasive brain stimulation, behavior and neuroimaging. The Administrative Core facilitates all Center activities with a focus on career development, grant proposal submission, and deployment of technology developed by our research cores. The Design and Analysis Core aims to provide principled study design expertise, statistical modeling, machine learning, inference, and computation. The Behavior and Neuroimaging Core provides project-specific collaboration and support to COBRE scientists to promote the acquisition of high quality behavioral, physiological, neuroimaging and neurostimulation data, to ensure the integrity of the data collection infrastructure and to help implement robust data processing and visualization pipelines. While the cores principally serve Center scientists, our Center and the core resources have availability to all Rhode Island researchers.

10.
R I Med J (2013) ; 104(3): 41-45, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789408

RESUMEN

The universities, hospitals, government agencies, and community organizations in Rhode Island (RI) are well-positioned to bridge gaps between basic and clinical science. RI's manageable size, population demographics, and organizational structure present opportunities to test and implement impactful, transformative clinical and translational research. However, the state's resources had not been optimally coordinated to develop a multi-institutional, clinical and translational research infrastructure to improve clinical practice effectiveness and impact health care in RI. The objective of Advance Clinical and Translational Research (Advance-CTR) is to bridge these gaps by creating a statewide hub to coordinate and leverage existing research resources and provide new career development support and funding for academic researchers, particularly junior investigators. Research support offerings are responsive to a wide variety of needs and readily available via a service request form on AdvanceCTR.org, the first of its kind on a statewide level.

11.
R I Med J (2013) ; 104(3): 46-48, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789409
12.
R I Med J (2013) ; 104(3): 49-50, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789410
13.
R I Med J (2013) ; 104(3): 51-52, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789411

RESUMEN

Numb Chin Syndrome (NCS) is a sensory neuropathy that was first described in the early 1800s. It has various etiologies, most commonly benign local pathology. However, NCS has been documented as the primary presenting symptom of systemic malignancy, most commonly breast cancer.1 This is the case of a young male who presented to the emergency department with complaints of a numb chin and was ultimately found to have invasive neoplastic lesions in the right tonsillar and mandibular regions of the face arising from metastatic large B-cell lymphoma.

14.
R I Med J (2013) ; 104(3): 53-57, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789412

RESUMEN

BACKGROUND: 10-20% of individuals diagnosed with Lyme disease develop chronic symptoms after antibiotic treatment. METHODS: A convenience sample of adults with self- reported, persistent post-Lyme treatment symptoms seeking treatment at the Lifespan Lyme Disease Center in Rhode Island completed a demographic and medical survey, the Patient Reported Outcomes Measurement Information System (PROMIS)-29 v2.0, and other short-form PROMIS measures of cognitive function, sleep disturbance, and fatigue. RESULTS: Compared to average standardized scale scores (T=50; SD=10), participants had mild impairments in physical (T=41) and social (T=42) functioning, mild symptoms of depression (T=56), anxiety (T=60), and sleep disturbance (T=57), and moderate pain interference (T=62), and fatigue (T=65). Participants reported greater symptoms than some other clinical samples including those with cancer and chronic pain. Post-hoc analyses revealed that women reported higher levels of fatigue than men. CONCLUSIONS: People with persistent post-Lyme treatment symptoms report debilitating symptoms and functional impairments which must be considered in clinical care.

15.
R I Med J (2013) ; 104(3): 58-61, 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789413

RESUMEN

BACKGROUND: Residents report low satisfaction with faculty evaluation and feedback. To improve skills, successful faculty development interventions must be accessible and acceptable. METHODS: A faculty development survey was admin- istered to 145 specialty and non-specialty Internal Medicine faculty at the Warren Alpert Medical School of Brown University, Providence, RI. Analyses assessed demographics, opinion regarding evaluation and feedback and interest in faculty development. RESULTS: Only 70% of faculty were satisfied with their evaluation ability and only 59% were satisfied with their feedback skills. Despite this, 32% had limited interest in faculty development. Non-specialty faculty were more interested than subspecialty faculty, p-value=0.02. Faculty preferred short electronic audio slideshows and 38% reported participation barriers. CONCLUSIONS: Although faculty report evaluation and feedback are important skills, not all were satisfied with their abilities. Subspecialty faculty were less interested than non-specialty in faculty development. Our findings suggest that more effective ways to engage faculty in the process of faculty development are needed.

17.
Asian Spine J ; 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789415

RESUMEN

Study Design: Electronic survey-based study. Purpose: The aim of the study was to objectively review the variability in the prevailing treatment protocols and surgical decision making in the management of patients with spinal tuberculosis (TB) among spine surgeons with expertise in spinal TB across the country. Overview of Literature: A lack of good-quality evidence, ambiguities in the national spinal TB guidelines, and the demand for early rehabilitation and a better quality of life in patients with spinal TB has led to the emergence of various gray zones in the management of spinal TB. Methods: Seventeen fellowship-trained spinal TB experts representing different geographical regions of India completed an online survey consisting of questions pertaining to the conservative management of spinal TB (antitubercular therapy) and 30 clinical case vignettes including a wide spectrum of presentations of spinal TB with no or minimal neurological deficit. The variability in the responses for questions and case wise variability with respect to surgical decision making was assessed using the index of qualitative variation (IQV). The average tendency to operate (TTO) was calculated for various groups of respondents. Results: High variability was observed in all questions regarding conservative spinal TB management (IQV > 0.8). Among the 30 case vignettes, 14 were found to have high variability with respect to surgical decision making (IQV > 0.8). With respect to levels of fixation, all but two cases had poor or slight agreement. Younger age and practice in a government or tertiary care teaching hospital were factors associated with a higher TTO. Conclusions: Significant variability was detected in treatment practices for the management of spinal TB among experts. Most of the case vignettes were found to have significant heterogeneity with respect to surgical decision making, which reflects a significant lack of consensus and lacunae in literature.

18.
Clin Endosc ; 2021 Apr 01.
Artículo en Inglés | MEDLINE | ID: mdl-33789416

RESUMEN

Acute liver failure due to malignant melanoma is uncommon. We presents a case of acute liver failure secondary to hepatic infiltration of a malignant melanoma. An 86-year-old man was admitted with elevated liver enzymes and an increased lactate dehydrogenase level. His condition progressed to acute liver failure, but the etiology of liver failure was unclear. Esophagogastroduodenoscopy was performed to evaluate dyspepsia, which showed signs indicative of malignant melanoma. Based on the endoscopy findings and elevated liver enzyme levels, liver biopsy was performed to confirm the presence of malignant melanoma. Hepatic infiltration of malignant melanoma was observed histologically. However, massive and diffuse liver metastasis is very rare and difficult to identify on imaging studies. If the etiology of liver failure is unclear, diffuse metastatic melanoma infiltration should be considered as differential diagnosis. Early liver biopsy can help to clarify the diagnosis.

19.
J Agric Food Chem ; 2021 Mar 31.
Artículo en Inglés | MEDLINE | ID: mdl-33789420

RESUMEN

Genetic variation is crucial for crop improvement. We adopted a gene editing approach to create variations in the rice genome by targeting the mutator locus homolog 2 (MSH2), a DNA mismatch repair gene. The hypothesis is that disruption of the MSH2 gene leads to a reduced DNA mismatch repair that creates INDELs, resulting in altered phenotypes. The Indica rice (IR-64) genotype was transformed with a guide RNA targeted to the MSH2 gene using an Agrobacterium-mediated in planta method. Many plants showed integration of Cas9 and gRNA constructs in rice plants. One of the msh2 mutants showed a superior phenotype due to editing and possible INDELs in the whole genome. The stable integration of the transgene and its flanking sequence analysis confirms no disruption of any gene, and the observed phenotype is due to the mutations in the MSH2 gene. Few transgenic plants showed disruption of genes due to T-DNA integration that led to altered phenotypes. The plants with altered phenotypes having more tiller number, early flowering, and robust growth with a high biomass were identified. These genetically reprogrammed rice plants could be a potential resource to create more segregating population or act as donor lines to stabilize the important agronomic traits that may help in a speed breeding process.

20.
J Org Chem ; 2021 Mar 31.
Artículo en Inglés | MEDLINE | ID: mdl-33789421

RESUMEN

A novel strategy for the synthesis of sulfides and selenides from phosphonium salts and thio- or selenesulfonates, commercially available compounds, is described. When phosphoranes were used in the reaction, different products were obtained. The methodology does not require the use of metals, reactive species, or anhydrous conditions to be performed.

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