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Sangre (Barc) ; 38(4): 295-9, 1993 Aug.
Artículo en Español | MEDLINE | ID: mdl-8235944

RESUMEN

PURPOSE: To evaluate the chemotactic capability of neutrophils in thalassaemic patients under poly-transfusion regimens and in thalassaemia carriers. PATIENTS AND METHODS: Twenty-one patients in multi-transfusion regimen diagnosed in the Ricardo Gutiérrez Children Hospital were studied. Of them, 17 had thalassaemia major, 3 S/beta thalassaemia and one sickle-cell anaemia. Twenty-one normal subjects comprised a control group. Chemotaxis was evaluated by two methods, namely, migration under agarose layer and in microchemotaxis chamber under stimulation with N-formyl-methionyl-n-phenylalanine at optimal concentrations of 10(-5) M and 10(-6) M, respectively. RESULTS: In thalassaemia major patients, directed mobility of neutrophil assessed by both methods was significantly decreased with regard to the normal controls, whereas random mobility was preserved. The four patients under poly-transfusion who had not thalassaemia major showed the same neutrophil defect. On the contrary, chemotaxis and random mobility of the neutrophils from thalassaemia carriers (thalassaemia minor) were similar to those of the normal controls. CONCLUSIONS: These results suggest that the defect found in the patients might be caused by transfusion overload.


Asunto(s)
Quimiotaxis , Síndromes de Inmunodeficiencia/etiología , Reacción a la Transfusión , Talasemia beta/inmunología , Adolescente , Adulto , Anciano , Anemia de Células Falciformes/sangre , Anemia de Células Falciformes/inmunología , Anemia de Células Falciformes/terapia , Niño , Femenino , Genotipo , Hematología/métodos , Humanos , Síndromes de Inmunodeficiencia/sangre , Masculino , Persona de Mediana Edad , Neutrófilos , Fagocitosis , Talasemia beta/sangre , Talasemia beta/terapia
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