Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 13 de 13
Filtrar
Más filtros










Base de datos
Intervalo de año de publicación
1.
Am J Mens Health ; 13(1): 1557988319831219, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30776946

RESUMEN

Paternal postnatal depression (PPND) is not a commonly recognized phenomenon. The aim of the study was to identify the Edinburgh Postnatal Depression Scale (EPDS) cutoff for Saudi fathers, to estimate PPND prevalence and to determine the risk factors of PPND among fathers of newborn in Saudi Arabia. A cross-sectional study of fathers with babies born up to 6 months prior to the survey was conducted. Fathers were screened using EPDS and demographic questionnaire. The fathers were selected using systematic random sampling from visitors to the birth registration office. A subsample of participants from the postnatal wards in a tertiary care was invited for additional evaluation by a psychologist using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for major depressive disorders. Receiver operating characteristic curve was utilized to identify fathers with depression; a cutoff of 8/9 was optimal to achieve sensitivity 77.8% and specificity 81.3%. Adjusted prevalence of PPND was reported with corresponding Wilson 95% confidence interval. Two hundred and ninety fathers completed the EPDS and demographic questionnaire. Of 72 invited participants, 57 (79.16%) attended the diagnostic interview. The average age of fathers was 34.97 ± 8.56 years, the average maternal age was 29.18 ± 7.41 years, average age of the newborn was 43.13 ± 35.88 days. PPND adjusted prevalence was 16.6% (95% CI [8.5, 25.6]). Paternal mental health needs equal attention during and postdelivery of newborn. Fathers should receive perinatal and postnatal mental health assessment to prevent behavioral problems in their children and disruption of relationship with their spouse.


Asunto(s)
Depresión Posparto/epidemiología , Padre/psicología , Adulto , Estudios Transversales , Femenino , Humanos , Recién Nacido , Masculino , Prevalencia , Escalas de Valoración Psiquiátrica , Factores de Riesgo , Arabia Saudita/epidemiología , Encuestas y Cuestionarios
2.
J Exp Psychol Gen ; 148(6): 1091-1102, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-30247060

RESUMEN

Daly and Wilson (1994, 2008) reported that rates of fatal assaults of young children by stepfathers are over 100 times those by genetic fathers, and they explain the difference in evolutionary terms. Their study was replicated by comparing updated homicide data and population data from 3 surveys. This indicated that the risk to young stepchildren was approximately 16 times that to genetic children, and stepfathers were twice as likely to kill by beating. However, when we controlled for father's age, the risk from cohabiting stepfathers was approximately 6 times greater. Above the age of 4 years, stepchildren were at no greater risk than genetic children. Children are at risk from fathers primarily when both are young and they do not live together; stepfathers' apparent overrepresentation results largely from their relative youth and from many nonresidential perpetrators being labeled stepfathers. Other factors are also influential, but if these include stepparenthood, its impact is considerably less than previous researchers have claimed. (PsycINFO Database Record (c) 2019 APA, all rights reserved).


Asunto(s)
Maltrato a los Niños/estadística & datos numéricos , Padre/estadística & datos numéricos , Homicidio/estadística & datos numéricos , Adolescente , Adulto , Niño , Preescolar , Inglaterra , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Persona de Mediana Edad , Gales
3.
Exp Clin Transplant ; 15(Suppl 1): 182-184, 2017 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-28260463

RESUMEN

Wilson disease is a genetic disease involving copper metabolism disturbances that result in copper accumulations, especially in the liver and brain. Wilson disease can be treated with pharmacologic agents, such as chelators that induce urinary excretion of copper or zinc salts that inhibit copper absorption in the digestive tract. Liver transplant is the only treatment option for Wilson disease when liver failure has occurred. In some patients, that is, in those with Child-Pugh A score, neurologic disease can be seen without hepatic failure. Our recommendation is for these patients to have auxiliary partial orthotopic liver transplant. Here, we present a 36-year-old male patient with neurologic disease associated with Wilson disease who had successful related living-donor auxiliary partial orthotopic liver transplant using a left lobe. The patient, as a result of neurologic symptoms that included tremor walking and speaking problems and low serum ceruloplasmin level of 7 mg/dL, was diagnosed with Wilson disease, and a liver biopsy was performed. Chronic necroinflammatory disease activity was 4/18, and the patient received chelation treatment. His hepatic functions were normal. The donor was the patient's 57-year-old father whose liver function tests were also normal. The graft-to-recipient weight ratio was 1% using a left lobe graft. After transplant, serum ceruloplasmin levels on day 15 and month 1 were 14 and 19 mg/dL. At month 1, liver function tests were normal. Doppler ultrasonography showed normal vascular flow of the native liver and the graft. The patient's neurologic symptoms were progressively reduced. Progressive neurologic deterioration with no hepatic insufficiency is considered a suitable indication for auxiliary partial orthotopic liver transplant; this procedure is suggested before the neurologic and liver failure symptoms of Wilson disease occur.


Asunto(s)
Enfermedad Hepática en Estado Terminal/cirugía , Degeneración Hepatolenticular/complicaciones , Trasplante de Hígado/métodos , Donadores Vivos , Adulto , Quelantes/uso terapéutico , Colangiopancreatografia Retrógrada Endoscópica , Enfermedad Hepática en Estado Terminal/diagnóstico , Enfermedad Hepática en Estado Terminal/etiología , Padre , Degeneración Hepatolenticular/diagnóstico , Degeneración Hepatolenticular/tratamiento farmacológico , Degeneración Hepatolenticular/genética , Humanos , Pruebas de Función Hepática , Masculino , Persona de Mediana Edad , Tomografía Computarizada por Rayos X , Resultado del Tratamiento
5.
Behav Processes ; 90(3): 415-9, 2012 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-22579440

RESUMEN

The present study investigated the preference of prepubescent and adult rats for an unrelated conspecific over a closely related conspecific (e.g., father, mother). Preference was measured by the amount of time spent in the vicinity of the stimulus animals as well as who was visited first. To prevent mating behavior, stimulus animals were housed behind wire-mesh. Experiment 1 determined if adult female offspring prefer an unrelated, unfamiliar adult male or their father. The preference of adult female rats was independent of kinship. Experiment 2 evaluated the preference of prepubescent female and male offspring for an unrelated, unfamiliar adult male or their father. The preference of prepubescent female and male rats was also independent of kinship. Experiment 3 evaluated the preference of adult male offspring for an unrelated, unfamiliar adult female or their mother. The preference of adult male rats was independent of kinship. In summary, prepubescent and adult rats do not demonstrate preference for kin vs. non-kin (as measured by time spent near stimulus animals or who was visited first). Although kin recognition provides a mechanism for inbreeding avoidance (Wilson, 1987), in the present study adult rats show no evidence of inbreeding avoidance.


Asunto(s)
Discriminación en Psicología/fisiología , Maduración Sexual/fisiología , Envejecimiento/psicología , Análisis de Varianza , Animales , Interpretación Estadística de Datos , Estradiol/análogos & derivados , Estradiol/farmacología , Padre , Femenino , Endogamia , Masculino , Preferencia en el Apareamiento Animal , Madres , Progesterona/farmacología , Ratas , Ratas Long-Evans , Conducta Sexual Animal/fisiología
6.
Diabetes ; 59(10): 2631-6, 2010 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-20622173

RESUMEN

OBJECTIVE: In animal studies, hyperglycemia during fetal development reduces nephron numbers. We tested whether this observation translates into renal dysfunction in humans by studying renal functional reserve in adult offspring exposed in utero to maternal type 1 diabetes. RESEARCH DESIGN AND METHODS: We compared 19 nondiabetic offspring of type 1 diabetic mothers with 18 offspring of type 1 diabetic fathers (control subjects). Glomerular filtration rate ((51)Cr-EDTA clearance), effective renal plasma flow ((123)I-hippurate clearance), mean arterial pressure, and renal vascular resistances were measured at baseline and during amino acid infusion, which mobilizes renal functional reserve. RESULTS: Offspring of type 1 diabetic mothers were similar to control subjects for age (median 27, range 18-41, years), sex, BMI (23.1 ± 3.7 kg/m(2)), and birth weight (3,288 ± 550 vs. 3,440 ± 489 g). During amino acid infusion, glomerular filtration rate and effective renal plasma flow increased less in offspring of type 1 diabetic mothers than in control subjects: from 103 ± 14 to 111 ± 17 ml/min (8 ± 13%) vs. from 108 ± 17 to 128 ± 23 ml/min (19 ± 7%, P = 0.009) and from 509 ± 58 to 536 ± 80 ml/min (5 ± 9%) vs. from 536 ± 114 to 620 ± 140 ml/min (16 ± 11%, P = 0.0035). Mean arterial pressure and renal vascular resistances declined less than in control subjects: 2 ± 5 vs. -2 ± 3% (P = 0.019) and 3 ± 9 vs. -14 ± 8% (P = 0.001). CONCLUSIONS: Reduced functional reserve may reflect a reduced number of nephrons undergoing individual hyperfiltration. If so, offspring of type 1 diabetic mothers may be predisposed to glomerular and vascular diseases.


Asunto(s)
Diabetes Mellitus Tipo 1/fisiopatología , Nefropatías Diabéticas/epidemiología , Embarazo en Diabéticas/epidemiología , Adolescente , Adulto , Edad de Inicio , Anciano , Velocidad del Flujo Sanguíneo , Presión Sanguínea , Niño , Preescolar , Diabetes Mellitus Tipo 1/sangre , Diabetes Mellitus Tipo 1/epidemiología , Nefropatías Diabéticas/fisiopatología , Padre , Femenino , Tasa de Filtración Glomerular , Humanos , Pruebas de Función Renal , Masculino , Persona de Mediana Edad , Madres , Embarazo , Resistencia Vascular/fisiología , Adulto Joven
7.
Transplant Proc ; 40(8): 2565-7, 2008 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-18929802

RESUMEN

We performed the first case of simultaneous pancreas and kidney transplantation from a living donor (LDSPK) in 2004. We examined the quality of life (QOL) of performed 6 recipients and 5 donors among 8 LDSPK from 2004 to 2007 at our institution using Short Form 36. All recipients achieved insulin and hemodialysis independence after LDSPK with positive serum C-peptide levels. Before LDSPK, all scores of the 8 specific domains of the recipients were low (28.2 +/- 10.6), indicating extremely poor QOL. Both the Physical and the Mental Component Summary Scores (PCS/MCS) quickly increased after LDSPK. PCS at 6, 12, and 24 months after LDSPK were significantly higher than the pretransplantation level. MCS were also significantly higher than the pretransplantation level. LDSPK showed prominent QOL improvement for the recipient. Complications were not observed in any donor. Although PCS decreased at 6 months after the operation, it recovered at 12 and at 24 months after the operation. MCS was maintained at more than 50 from 6 to 24 months after the operation. QOL was well preserved in the LDSPK donors despite the major surgery. In conclusion, LDSPK was confirmed to be a potent tool for treatment of type 1 diabetes mellitus patients with end-stage renal disease (ESRD) by complete normalization of glucose metabolism and renal function. In addition to these medical advantages, both their physical and mental QOL were improved by LDSPK.


Asunto(s)
Diabetes Mellitus Tipo 1/cirugía , Nefropatías Diabéticas/cirugía , Fallo Renal Crónico/cirugía , Trasplante de Riñón/fisiología , Trasplante de Páncreas/fisiología , Calidad de Vida , Adulto , Padre , Femenino , Humanos , Insulina/uso terapéutico , Trasplante de Riñón/psicología , Donadores Vivos , Masculino , Persona de Mediana Edad , Madres , Nefrectomía/métodos , Trasplante de Páncreas/psicología , Pancreatectomía/métodos , Diálisis Renal , Encuestas y Cuestionarios
9.
Pediatr Transplant ; 3(3): 201-5, 1999 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-10487279

RESUMEN

We reviewed the outcome of children undergoing living related liver transplantation (LRLT) for Wilson's disease (WD), and specifically addressed the potential risk associated with the use of donors who were heterozygous for the Wilson genetic defect. LRLTs were carried out in 11 children with WD, nine of whom presented with fulminant hepatic failure and two with end-stage hepatic insufficiency. The age of the patients ranged from 6 to 16 yr. Eight patients had hepatic encephalopathy and were plasmapheresed preoperatively. The donors (all parents: six fathers and five mothers) were all one-haplotype matched with their respective recipients, and were all therefore heterozygote carriers of the WD genetic defect. The serum ceruloplasmin levels were within normal limits in all donors (mean: 20.0 +/- 2.85 mg/dL). All recipients but one had low serum ceruloplasmin levels with a mean value of 11.6 +/- 7.36 mg/dL before transplantation. The serum ceruloplasmin levels had increased to an average of 21.0 +/- 3.76 mg/dL after LRLT at the latest evaluation, which ranged between 7 and 75 months after transplantation. A marked reduction in urinary copper excretion was observed in all recipients after transplantation. Of eight recipients presenting preoperatively with Kayser-Fleischer (K-F) rings, this abnormality resolved completely after LRLT in five patients and partially in three. All recipients are alive and remain well, and none have developed signs of recurrent WD after a mean follow-up period of 31 months (range 7-75 months). In conclusion, LRLT is an excellent choice for effective treatment of WD, and grafts chosen from heterozygote carriers of the condition do not appear to confer any risk of recurrence in the recipients.


Asunto(s)
Degeneración Hepatolenticular/cirugía , Heterocigoto , Trasplante de Hígado , Donantes de Tejidos , Adolescente , Ceruloplasmina/análisis , Niño , Cobre/metabolismo , Padre , Femenino , Estudios de Seguimiento , Haplotipos , Degeneración Hepatolenticular/genética , Degeneración Hepatolenticular/metabolismo , Humanos , Inmunosupresión , Masculino , Madres , Factores de Tiempo , Resultado del Tratamiento
10.
Diabetologia ; 39(4): 433-8, 1996 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-8777992

RESUMEN

To determine if parental hypertension is associated with proteinuria in offspring with non-insulin-dependent diabetes mellitus (NIDDM), 438 diabetic Pima Indians (172 men, 266 women) aged 20 years or more and both of their parents were examined. Hypertension was defined as a systolic blood pressure 140 mm Hg or more, diastolic blood pressure 90 mm Hg or more, or treatment with antihypertensive medicine. Sixty-three percent of the fathers and 80% of the mothers had diabetes at the time their blood pressure was measured. Families in which either parent had proteinuria, defined as a urine protein-to-creatinine ratio > or = 0.5 g/g were excluded; 73 (16.7%) of the offspring had proteinuria. The prevalence rates of proteinuria in the offspring were similar if neither parent or only one parent had hypertension (8.9 and 9.4%, respectively), but was significantly higher if both parents had hypertension (18.8%), after adjustment for age, sex, duration of diabetes, and 2-h post-load plasma glucose concentration in the offspring and diabetes in the parents by logistic regression. The odds for proteinuria being present in the offspring if both parents had hypertension was 2.2 times (95% confidence interval, 1.2 to 4.2) that if only one parent had hypertension. When mean arterial pressure and blood pressure treatment in the offspring were added to the model the relationship remained (odds ratio = 2.2; 95% confidence interval, 1.1 to 4.3). Hypertension in both parents is associated with the development of proteinuria in offspring with NIDDM. This relationship was present even when controlled for the effects of blood pressure and its treatment in the offspring.


Asunto(s)
Presión Sanguínea , Diabetes Mellitus Tipo 2/genética , Hipertensión/genética , Proteinuria/genética , Adulto , Factores de Edad , Arizona , Glucemia/metabolismo , Creatinina/orina , Nefropatías Diabéticas/epidemiología , Nefropatías Diabéticas/genética , Padre , Femenino , Humanos , Hipertensión/epidemiología , Indios Norteamericanos , Masculino , Persona de Mediana Edad , Madres , Prevalencia , Proteinuria/epidemiología , Caracteres Sexuales
13.
Ann Pediatr (Paris) ; 38(5): 350-4, 1991 May.
Artículo en Francés | MEDLINE | ID: mdl-1872531

RESUMEN

A new case of trisomy 4p is reported. The patient was a boy with dysmorphism, growth failure and developmental retardation. Craniofacial features included microcephaly with a flat forehead, a prominent glabella, hyperteleorism, a broad, concave nasal bridge, a bulb-shaped nose, a wide mouth with a prominent upper lip and a short philtrum, low-set ears, a low hairline, micrognathia, and a short neck. Abdominal muscles were normal. Cryptorchidism with a hypoplastic scrotum and a micropenis were found, as well as forced flexion of the fingers and talipes equinus. The intravenous urogram disclosed ptosis of the right kidney. Developmental retardation was severe with an IQ under 50. RHG banding techniques on peripheral lymphocytes disclosed 4p14 pter duplication. The karyotype was 46,XY inv dup(4-p) (p14----pter). The mother's karyotype was normal. The father had a translocation between the short arm of chromosome 4 and the long arm of chromosome 15; his karyotype was 46,XY, t(4;15) (p14;q26). Thus, the child had trisomy for a segment of the short arm of chromosome 4 (p14----pter) and monosomy for the terminal band of the long arm of chromosome 15 (15q26). The first case of trisomy 4p was reported in 1970 by Wilson et al. Since then, there have been 46 additional reports in the medical literature. Although children with trisomy 4p share a number of features, the phenotypic manifestations of this chromosomal abnormality are variable and nonspecific, making clinical diagnosis difficult.


Asunto(s)
Cromosomas Humanos Par 4 , Trisomía , Preescolar , Padre , Humanos , Cariotipificación , Masculino , Fenotipo , Translocación Genética/genética
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA